Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc198_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 9 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004532 exoribonuclease activity 3.324E-17 2.991E-16 8.462E-16 2.991E-16 6 36
2 GO:0004527 exonuclease activity 5.975E-15 2.689E-14 7.606E-14 5.378E-14 6 82
3 GO:0004540 ribonuclease activity 2.440E-14 7.319E-14 2.071E-13 2.196E-13 6 103
4 GO:0004518 nuclease activity 3.285E-12 7.392E-12 2.091E-11 2.957E-11 6 230
5 GO:0017091 AU-rich element binding 3.263E-8 5.873E-8 1.662E-7 2.937E-7 3 23
6 GO:0000175 3'-5'-exoribonuclease activity 7.474E-8 1.064E-7 3.009E-7 6.727E-7 3 30
7 GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters 8.274E-8 1.064E-7 3.009E-7 7.446E-7 3 31
8 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3.177E-7 3.574E-7 1.011E-6 2.859E-6 3 48
9 GO:0008408 3'-5' exonuclease activity 4.058E-7 4.058E-7 1.148E-6 3.652E-6 3 52
Show 4 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 117 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 8.205E-18 7.023E-16 3.753E-15 9.600E-16 6 29
2 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic 1.565E-17 7.023E-16 3.753E-15 1.831E-15 6 32
3 GO:0034475 U4 snRNA 3'-end processing 1.801E-17 7.023E-16 3.753E-15 2.107E-15 5 8
4 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' 4.051E-17 1.185E-15 6.332E-15 4.740E-15 5 9
5 GO:0034472 snRNA 3'-end processing 8.103E-17 1.896E-15 1.013E-14 9.480E-15 5 10
6 GO:0071028 nuclear mRNA surveillance 2.546E-16 4.256E-15 2.274E-14 2.979E-14 5 12
7 GO:0071027 nuclear RNA surveillance 2.546E-16 4.256E-15 2.274E-14 2.979E-14 5 12
8 GO:0031125 rRNA 3'-end processing 4.138E-16 6.051E-15 3.234E-14 4.841E-14 5 13
9 GO:0071025 RNA surveillance 6.436E-16 8.367E-15 4.471E-14 7.530E-14 5 14
10 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1.891E-15 2.212E-14 1.182E-13 2.212E-13 6 68
11 GO:0016075 rRNA catabolic process 2.754E-15 2.929E-14 1.565E-13 3.222E-13 5 18
12 GO:0016180 snRNA processing 8.463E-15 8.251E-14 4.409E-13 9.901E-13 5 22
13 GO:0043628 ncRNA 3'-end processing 1.081E-14 9.732E-14 5.200E-13 1.265E-12 5 23
14 GO:0034661 ncRNA catabolic process 1.707E-14 1.427E-13 7.624E-13 1.997E-12 5 25
15 GO:0043488 regulation of mRNA stability 1.925E-13 1.501E-12 8.023E-12 2.252E-11 6 144
16 GO:0043487 regulation of RNA stability 2.275E-13 1.664E-12 8.891E-12 2.662E-11 6 148
17 GO:0000956 nuclear-transcribed mRNA catabolic process 1.512E-12 1.041E-11 5.561E-11 1.769E-10 6 202
18 GO:0006402 mRNA catabolic process 2.402E-12 1.562E-11 8.345E-11 2.811E-10 6 218
19 GO:0006401 RNA catabolic process 5.125E-12 3.156E-11 1.686E-10 5.996E-10 6 247
20 GO:0006364 rRNA processing 6.993E-12 4.091E-11 2.186E-10 8.182E-10 6 260
21 GO:0016072 rRNA metabolic process 8.214E-12 4.576E-11 2.445E-10 9.610E-10 6 267
22 GO:0016073 snRNA metabolic process 9.305E-12 4.949E-11 2.644E-10 1.089E-9 5 83
23 GO:0042254 ribosome biogenesis 2.552E-11 1.298E-10 6.936E-10 2.986E-9 6 322
24 GO:0031123 RNA 3'-end processing 6.097E-11 2.973E-10 1.588E-9 7.134E-9 5 120
25 GO:0034470 ncRNA processing 9.322E-11 4.362E-10 2.331E-9 1.091E-8 6 399
26 GO:0034655 nucleobase-containing compound catabolic process 1.234E-10 5.555E-10 2.968E-9 1.444E-8 6 418
27 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic 1.563E-10 6.775E-10 3.620E-9 1.829E-8 4 35
28 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing 1.858E-10 7.763E-10 4.148E-9 2.174E-8 3 5
29 GO:0044270 cellular nitrogen compound catabolic process 2.258E-10 9.039E-10 4.830E-9 2.642E-8 6 462
30 GO:0046700 heterocycle catabolic process 2.318E-10 9.039E-10 4.830E-9 2.712E-8 6 464
31 GO:0022613 ribonucleoprotein complex biogenesis 2.441E-10 9.212E-10 4.923E-9 2.856E-8 6 468
32 GO:0019439 aromatic compound catabolic process 2.636E-10 9.465E-10 5.058E-9 3.084E-8 6 474
33 GO:0010608 posttranscriptional regulation of gene expression 2.670E-10 9.465E-10 5.058E-9 3.123E-8 6 475
34 GO:0031126 snoRNA 3'-end processing 1.040E-9 3.579E-9 1.912E-8 1.217E-7 3 8
35 GO:0045006 DNA deamination 2.228E-9 7.241E-9 3.869E-8 2.607E-7 3 10
36 GO:0043144 snoRNA processing 2.228E-9 7.241E-9 3.869E-8 2.607E-7 3 10
37 GO:0016074 snoRNA metabolic process 4.084E-9 1.291E-8 6.900E-8 4.778E-7 3 12
38 GO:0090501 RNA phosphodiester bond hydrolysis 3.364E-8 1.036E-7 5.535E-7 3.936E-6 4 130
39 GO:0000460 maturation of 5.8S rRNA 9.185E-8 2.755E-7 1.472E-6 1.075E-5 3 32
40 GO:0034473 U1 snRNA 3'-end processing 2.595E-7 7.405E-7 3.957E-6 3.036E-5 2 3
41 GO:0034476 U5 snRNA 3'-end processing 2.595E-7 7.405E-7 3.957E-6 3.036E-5 2 3
42 GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process 5.189E-7 1.412E-6 7.544E-6 6.071E-5 2 4
43 GO:0071047 polyadenylation-dependent mRNA catabolic process 5.189E-7 1.412E-6 7.544E-6 6.071E-5 2 4
44 GO:0090305 nucleic acid phosphodiester bond hydrolysis 6.526E-7 1.735E-6 9.273E-6 7.635E-5 4 272
45 GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process 8.647E-7 2.248E-6 1.201E-5 1.012E-4 2 5
46 GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process 1.297E-6 3.035E-6 1.622E-5 1.517E-4 2 6
47 GO:0071046 nuclear polyadenylation-dependent ncRNA catabolic process 1.297E-6 3.035E-6 1.622E-5 1.517E-4 2 6
48 GO:0016078 tRNA catabolic process 1.297E-6 3.035E-6 1.622E-5 1.517E-4 2 6
49 GO:0043634 polyadenylation-dependent ncRNA catabolic process 1.297E-6 3.035E-6 1.622E-5 1.517E-4 2 6
50 GO:0071029 nuclear ncRNA surveillance 1.297E-6 3.035E-6 1.622E-5 1.517E-4 2 6
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 5 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000176 nuclear exosome (RNase complex) 7.520E-20 3.760E-19 8.585E-19 3.760E-19 6 15
2 GO:0000178 exosome (RNase complex) 8.153E-19 2.038E-18 4.654E-18 4.076E-18 6 21
3 GO:0000177 cytoplasmic exosome (RNase complex) 8.594E-16 1.432E-15 3.271E-15 4.297E-15 5 15
4 GO:0035327 transcriptionally active chromatin 1.729E-5 2.162E-5 4.936E-5 8.647E-5 2 21
5 GO:0000785 chromatin 9.128E-3 9.128E-3 2.084E-2 4.564E-2 2 487

4: Human Phenotype [Display Chart] 1 input genes in category / 15 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 1 input genes in category / 4 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003179 thrombocytopenia 2.125E-2 4.017E-2
8.370E-2
8.498E-2
 1 220
2 MP:0011898 abnormal platelet cell number 2.878E-2 4.017E-2
8.370E-2
1.151E-1
 1 298
3 MP:0004720 abnormal platelet morphology 3.844E-2 4.017E-2
8.370E-2
1.537E-1
 1 398
4 MP:0013662 decreased myeloid cell number 4.017E-2 4.017E-2
8.370E-2
1.607E-1
 1 416

6: Domain [Display Chart] 6 input genes in category / 17 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3.30.230.70 - Gene3D 1.873E-18 1.592E-17 5.475E-17 3.183E-17 5 6
2 IPR027408 PNPase/RNase PH dom InterPro 1.873E-18 1.592E-17 5.475E-17 3.183E-17 5 6
3 IPR015847 ExoRNase PH dom2 InterPro 6.554E-18 2.785E-17 9.580E-17 1.114E-16 5 7
4 PF01138 RNase PH Pfam 6.554E-18 2.785E-17 9.580E-17 1.114E-16 5 7
5 IPR001247 ExoRNase PH dom1 InterPro 7.863E-17 2.673E-16 9.196E-16 1.337E-15 5 10
6 PF03725 RNase PH C Pfam 4.384E-14 1.242E-13 4.272E-13 7.452E-13 4 6
7 IPR020568 Ribosomal S5 D2-typ fold InterPro 1.012E-13 2.457E-13 8.452E-13 1.720E-12 5 35
8 IPR033196 Rrp43 InterPro 3.203E-4 5.444E-4 1.873E-3 5.444E-3 1 1
9 PF10447 EXOSC1 Pfam 3.203E-4 5.444E-4 1.873E-3 5.444E-3 1 1
10 IPR019495 EXOSC1 InterPro 3.203E-4 5.444E-4 1.873E-3 5.444E-3 1 1
11 IPR025721 Exosome cplx N dom InterPro 6.404E-4 9.073E-4 3.121E-3 1.089E-2 1 2
12 PF14382 ECR1 N Pfam 6.404E-4 9.073E-4 3.121E-3 1.089E-2 1 2
13 PS50126 S1 PROSITE 3.199E-3 4.077E-3 1.402E-2
5.438E-2
 1 10
14 IPR003029 S1 domain InterPro 3.837E-3 4.077E-3 1.402E-2
6.524E-2
 1 12
15 SM00316 S1 SMART 3.837E-3 4.077E-3 1.402E-2
6.524E-2
 1 12
16 IPR022967 S1 dom InterPro 3.837E-3 4.077E-3 1.402E-2
6.524E-2
 1 12
17 IPR012340 NA-bd OB-fold InterPro 2.661E-2 2.661E-2
9.151E-2
4.523E-1
 1 84
Show 12 more annotations

7: Pathway [Display Chart] 6 input genes in category / 14 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269714 mRNA decay by 3' to 5' exoribonuclease BioSystems: REACTOME 2.396E-18 1.677E-17 5.453E-17 3.354E-17 6 17
2 1269727 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA BioSystems: REACTOME 3.593E-18 1.677E-17 5.453E-17 5.031E-17 6 18
3 1269728 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA BioSystems: REACTOME 3.593E-18 1.677E-17 5.453E-17 5.031E-17 6 18
4 1269729 KSRP (KHSRP) binds and destabilizes mRNA BioSystems: REACTOME 5.252E-18 1.838E-17 5.977E-17 7.353E-17 6 19
5 1268762 ATF4 activates genes BioSystems: REACTOME 5.730E-17 1.604E-16 5.217E-16 8.022E-16 6 27
6 1268761 PERK regulates gene expression BioSystems: REACTOME 1.149E-16 2.682E-16 8.720E-16 1.609E-15 6 30
7 1269712 Deadenylation-dependent mRNA decay BioSystems: REACTOME 7.024E-15 1.405E-14 4.568E-14 9.834E-14 6 57
8 117291 RNA degradation BioSystems: KEGG 4.589E-14 8.032E-14 2.611E-13 6.425E-13 6 77
9 1269725 Regulation of mRNA stability by proteins that bind AU-rich elements BioSystems: REACTOME 1.475E-13 2.066E-13 6.717E-13 2.066E-12 6 93
10 1268756 Unfolded Protein Response (UPR) BioSystems: REACTOME 1.475E-13 2.066E-13 6.717E-13 2.066E-12 6 93
11 1383086 Major pathway of rRNA processing in the nucleolus and cytosol BioSystems: REACTOME 8.694E-12 1.107E-11 3.598E-11 1.217E-10 6 181
12 1427846 rRNA processing in the nucleus and cytosol BioSystems: REACTOME 1.285E-11 1.499E-11 4.873E-11 1.798E-10 6 193
13 1383085 rRNA processing BioSystems: REACTOME 1.746E-11 1.881E-11 6.115E-11 2.445E-10 6 203
14 M14532 PI3K Pathway MSigDB C2 BIOCARTA (v6.0) 1.770E-2 1.770E-2
5.756E-2
2.478E-1
 1 37
Show 9 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 93 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 27345150 Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex. Pubmed 1.949E-23 1.511E-21 7.728E-21 1.813E-21 6 9
2 28877463 Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase. Pubmed 4.873E-23 1.511E-21 7.728E-21 4.532E-21 6 10
3 17174896 Reconstitution, activities, and structure of the eukaryotic RNA exosome. Pubmed 4.873E-23 1.511E-21 7.728E-21 4.532E-21 6 10
4 12788944 The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. Pubmed 1.072E-22 2.493E-21 1.275E-20 9.971E-21 6 11
5 12419256 Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. Pubmed 2.144E-22 3.988E-21 2.040E-20 1.994E-20 6 12
6 11812149 Protein-protein interactions of hCsl4p with other human exosome subunits. Pubmed 3.982E-22 4.629E-21 2.368E-20 3.703E-20 6 13
7 20531389 Dis3-like 1: a novel exoribonuclease associated with the human exosome. Pubmed 3.982E-22 4.629E-21 2.368E-20 3.703E-20 6 13
8 21255825 The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Pubmed 3.982E-22 4.629E-21 2.368E-20 3.703E-20 6 13
9 11719186 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Pubmed 4.308E-21 4.006E-20 2.049E-19 4.006E-19 6 18
10 20531386 The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. Pubmed 4.308E-21 4.006E-20 2.049E-19 4.006E-19 6 18
11 25043052 Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA. Pubmed 5.317E-20 4.495E-19 2.299E-18 4.945E-18 5 6
12 11110791 Three novel components of the human exosome. Pubmed 7.018E-18 5.439E-17 2.782E-16 6.526E-16 5 12
13 11879549 Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. Pubmed 1.184E-14 8.472E-14 4.334E-13 1.101E-12 4 8
14 15231747 A protein interaction framework for human mRNA degradation. Pubmed 5.387E-13 3.579E-12 1.831E-11 5.010E-11 6 347
15 21791617 DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. Pubmed 7.538E-11 4.673E-10 2.390E-9 7.010E-9 3 7
16 15635413 Nucleolar proteome dynamics. Pubmed 9.227E-10 5.363E-9 2.743E-8 8.581E-8 5 419
17 16912217 Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. Pubmed 2.057E-8 1.125E-7 5.755E-7 1.913E-6 2 2
18 25693804 Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. Pubmed 8.297E-8 4.287E-7 2.193E-6 7.716E-6 4 332
19 20699273 A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination. Pubmed 1.234E-7 6.039E-7 3.089E-6 1.147E-5 2 4
20 10465791 The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. Pubmed 3.084E-7 1.434E-6 7.336E-6 2.868E-5 2 6
21 17545563 Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. Pubmed 4.318E-7 1.912E-6 9.780E-6 4.015E-5 2 7
22 21876179 Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. Pubmed 7.400E-7 3.128E-6 1.600E-5 6.882E-5 2 9
23 22174317 Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. Pubmed 3.056E-6 1.236E-5 6.321E-5 2.842E-4 3 206
24 27926873 FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3. Pubmed 5.332E-6 2.066E-5 1.057E-4 4.959E-4 3 248
25 22922362 Transcription factor Foxp3 and its protein partners form a complex regulatory network. Pubmed 1.600E-5 5.950E-5 3.044E-4 1.488E-3 3 358
26 27113764 The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Pubmed 2.613E-5 9.348E-5 4.782E-4 2.430E-3 3 422
27 18157497 Activation of cytotoxic T lymphocytes against CML28-bearing tumors by dendritic cells transduced with a recombinant adeno-associated virus encoding the CML28 gene. Pubmed 1.571E-4 4.174E-4 2.135E-3 1.461E-2 1 1
28 20660080 Structural and biochemical characterization of CRN-5 and Rrp46: an exosome component participating in apoptotic DNA degradation. Pubmed 1.571E-4 4.174E-4 2.135E-3 1.461E-2 1 1
29 11967169 Messenger RNA degradation: beginning at the end. Pubmed 1.571E-4 4.174E-4 2.135E-3 1.461E-2 1 1
30 27538750 cDNA-library testing identifies transforming genes cooperating with c-myc in mouse pre-B cells. Pubmed 1.571E-4 4.174E-4 2.135E-3 1.461E-2 1 1
31 24989451 EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. Pubmed 1.571E-4 4.174E-4 2.135E-3 1.461E-2 1 1
32 11849973 The yin and yang of the exosome. Pubmed 1.571E-4 4.174E-4 2.135E-3 1.461E-2 1 1
33 22488912 Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases. Pubmed 1.571E-4 4.174E-4 2.135E-3 1.461E-2 1 1
34 12359762 CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells. Pubmed 1.571E-4 4.174E-4 2.135E-3 1.461E-2 1 1
35 22068837 Yeast RNA viruses as indicators of exosome activity: human exosome hCsl4p participates in RNA degradation in Saccharomyces cerevisiae'. Pubmed 1.571E-4 4.174E-4 2.135E-3 1.461E-2 1 1
36 30217970 rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. Pubmed 2.039E-4 5.267E-4 2.694E-3 1.896E-2 2 142
37 23349634 A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Pubmed 2.126E-4 5.343E-4 2.733E-3 1.977E-2 2 145
38 22407013 Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA. Pubmed 3.142E-4 6.795E-4 3.476E-3 2.922E-2 1 2
39 17185417 The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA. Pubmed 3.142E-4 6.795E-4 3.476E-3 2.922E-2 1 2
40 11929972 A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity. Pubmed 3.142E-4 6.795E-4 3.476E-3 2.922E-2 1 2
41 23392705 Interaction of human genes WT1 and CML28 in leukemic cells. Pubmed 3.142E-4 6.795E-4 3.476E-3 2.922E-2 1 2
42 28144684 Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters : A single-center analysis. Pubmed 3.142E-4 6.795E-4 3.476E-3 2.922E-2 1 2
43 16815301 Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector. Pubmed 3.142E-4 6.795E-4 3.476E-3 2.922E-2 1 2
44 11790298 Directed proteomic analysis of the human nucleolus. Pubmed 4.364E-4 8.944E-4 4.575E-3 4.059E-2 2 208
45 7604013 Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. Pubmed 4.712E-4 8.944E-4 4.575E-3 4.382E-2 1 3
46 18334637 p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein. Pubmed 4.712E-4 8.944E-4 4.575E-3 4.382E-2 1 3
47 11782436 The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. Pubmed 4.712E-4 8.944E-4 4.575E-3 4.382E-2 1 3
48 27193168 Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy. Pubmed 4.712E-4 8.944E-4 4.575E-3 4.382E-2 1 3
49 23844004 Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA. Pubmed 4.712E-4 8.944E-4 4.575E-3 4.382E-2 1 3
50 19060904 An empirical framework for binary interactome mapping. Pubmed 5.377E-4 1.000E-3 5.116E-3
5.000E-2
 2 231
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 265 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:DIS3L DIS3L interactions 8.820E-18 2.337E-15 1.439E-14 2.337E-15 6 28
2 int:C1D C1D interactions 2.121E-17 2.811E-15 1.731E-14 5.622E-15 6 32
3 int:EXOSC3 EXOSC3 interactions 3.800E-17 3.357E-15 2.067E-14 1.007E-14 6 35
4 int:EXOSC7 EXOSC7 interactions 1.907E-16 1.263E-14 7.780E-14 5.053E-14 6 45
5 int:MPHOSPH6 MPHOSPH6 interactions 2.514E-16 1.269E-14 7.815E-14 6.661E-14 6 47
6 int:HBS1L HBS1L interactions 2.873E-16 1.269E-14 7.815E-14 7.613E-14 6 48
7 int:AICDA AICDA interactions 7.601E-16 2.878E-14 1.772E-13 2.014E-13 6 56
8 int:EXOSC6 EXOSC6 interactions 1.934E-15 6.405E-14 3.945E-13 5.124E-13 6 65
9 int:EXOSC1 EXOSC1 interactions 2.806E-15 8.263E-14 5.089E-13 7.437E-13 6 69
10 int:EXOSC8 EXOSC8 interactions 3.353E-15 8.885E-14 5.472E-13 8.885E-13 6 71
11 int:DIS3 DIS3 interactions 4.337E-15 9.577E-14 5.899E-13 1.149E-12 6 74
12 int:EXOSC9 EXOSC9 interactions 4.337E-15 9.577E-14 5.899E-13 1.149E-12 6 74
13 int:EXOSC5 EXOSC5 interactions 5.551E-15 1.131E-13 6.969E-13 1.471E-12 6 77
14 int:EXOSC10 EXOSC10 interactions 9.516E-15 1.801E-13 1.109E-12 2.522E-12 6 84
15 int:EXOSC2 EXOSC2 interactions 1.182E-14 2.089E-13 1.286E-12 3.133E-12 6 87
16 int:MTREX MTREX interactions 6.587E-14 1.091E-12 6.719E-12 1.746E-11 6 115
17 int:EXOSC4 EXOSC4 interactions 8.124E-14 1.266E-12 7.799E-12 2.153E-11 6 119
18 int:MPP6 MPP6 interactions 8.760E-13 1.290E-11 7.943E-11 2.321E-10 5 50
19 int:RBM7 RBM7 interactions 2.257E-12 3.148E-11 1.939E-10 5.981E-10 5 60
20 int:UPF2 UPF2 interactions 1.208E-8 1.600E-7 9.857E-7 3.201E-6 4 96
21 int:ZCCHC8 ZCCHC8 interactions 8.943E-7 1.129E-5 6.951E-5 2.370E-4 3 64
22 int:IFI16 IFI16 interactions 2.470E-6 2.975E-5 1.832E-4 6.546E-4 4 361
23 int:DDX60 DDX60 interactions 5.258E-6 6.058E-5 3.731E-4 1.393E-3 2 11
24 int:XRN1 XRN1 interactions 5.837E-6 6.445E-5 3.969E-4 1.547E-3 3 119
25 int:DXO DXO interactions 1.146E-5 1.215E-4 7.484E-4 3.038E-3 2 16
26 int:PSMA5 PSMA5 interactions 1.242E-5 1.266E-4 7.797E-4 3.292E-3 3 153
27 int:PSMA6 PSMA6 interactions 1.317E-5 1.292E-4 7.959E-4 3.489E-3 3 156
28 int:LUM LUM interactions 1.633E-5 1.545E-4 9.517E-4 4.327E-3 2 19
29 int:SLIT2 SLIT2 interactions 1.814E-5 1.602E-4 9.868E-4 4.807E-3 2 20
30 int:METTL22 METTL22 interactions 1.814E-5 1.602E-4 9.868E-4 4.807E-3 2 20
31 int:PSMA1 PSMA1 interactions 3.584E-5 3.064E-4 1.887E-3 9.499E-3 3 218
32 int:DMRTB1 DMRTB1 interactions 5.031E-5 4.166E-4 2.566E-3 1.333E-2 2 33
33 int:REL REL interactions 5.393E-5 4.331E-4 2.667E-3 1.429E-2 3 250
34 int:PSMA3 PSMA3 interactions 8.476E-5 6.606E-4 4.068E-3 2.246E-2 3 291
35 int:FOXA1 FOXA1 interactions 8.738E-5 6.616E-4 4.075E-3 2.316E-2 3 294
36 int:RSRC1 RSRC1 interactions 9.843E-5 7.168E-4 4.415E-3 2.608E-2 2 46
37 int:LSM7 LSM7 interactions 1.028E-4 7.168E-4 4.415E-3 2.724E-2 2 47
38 int:LSM1 LSM1 interactions 1.028E-4 7.168E-4 4.415E-3 2.724E-2 2 47
39 int:SH3GLB2 SH3GLB2 interactions 1.072E-4 7.287E-4 4.488E-3 2.842E-2 2 48
40 int:LRRC47 LRRC47 interactions 1.164E-4 7.713E-4 4.750E-3 3.085E-2 2 50
41 int:DHPS DHPS interactions 1.462E-4 9.451E-4 5.821E-3 3.875E-2 2 56
42 int:SRPK3 SRPK3 interactions 1.853E-4 1.152E-3 7.092E-3 4.909E-2 2 63
43 int:ZFP36 ZFP36 interactions 1.912E-4 1.152E-3 7.092E-3
5.067E-2
 2 64
44 int:PSIP1 PSIP1 interactions 1.912E-4 1.152E-3 7.092E-3
5.067E-2
 2 64
45 int:LSM3 LSM3 interactions 2.034E-4 1.198E-3 7.376E-3
5.389E-2
 2 66
46 int:TBL3 TBL3 interactions 2.223E-4 1.281E-3 7.888E-3
5.892E-2
 2 69
47 int:TEX11 TEX11 interactions 2.421E-4 1.349E-3 8.311E-3
6.416E-2
 2 72
48 int:FOXP3 FOXP3 interactions 2.444E-4 1.349E-3 8.311E-3
6.477E-2
 3 416
49 int:NMI NMI interactions 2.915E-4 1.562E-3 9.620E-3
7.726E-2
 2 79
50 int:WDTC1 WDTC1 interactions 3.062E-4 1.562E-3 9.620E-3
8.114E-2
 3 449
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 13q13.1 13q13.1 2.248E-3 1.349E-2 3.305E-2 1.349E-2 1 13
2 10q24 10q24 6.044E-3 1.813E-2 4.442E-2 3.626E-2 1 35
3 19q13.1 19q13.1 9.484E-3 1.897E-2 4.647E-2
5.690E-2
 1 55
4 3p21.31 3p21.31 1.770E-2 2.179E-2
5.337E-2
1.062E-1
 1 103
5 16q22.1 16q22.1 1.957E-2 2.179E-2
5.337E-2
1.174E-1
 1 114
6 8q24.3 8q24.3 2.179E-2 2.179E-2
5.337E-2
1.307E-1
 1 127
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 9 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 6 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 817 Exosome complex genenames.org 1.836E-20 1.836E-20 1.836E-20 1.836E-20 6 12

13: Coexpression [Display Chart] 6 input genes in category / 399 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5922 Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum. MSigDB H: Hallmark Gene Sets (v6.0) 2.245E-6 8.956E-4 5.882E-3 8.956E-4 3 113
2 M2830 Genes up-regulated in SH-SY5Y cells (neuroblastoma) in response to PDGF [Gene ID=] stimulation after pre-treatment with the ERK inhibitors U0126 and PD98059 [PubChem=3006531, 4713]. MSigDB C6: Oncogenic Signatures (v6.0) 5.834E-4 3.346E-2
2.197E-1
2.328E-1
 2 146
3 M6396 Genes down-regulated in plasma cells versus memory B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 3.346E-2
2.197E-1
4.306E-1
 2 199
4 M8724 Genes up-regulated in bone marrow-derived macrophages with heterozygous MLL4 [GeneID=9757] knockout: 2h LPS versus 4h LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 3.346E-2
2.197E-1
4.306E-1
 2 199
5 M4358 Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 48 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 48 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.346E-2
2.197E-1
4.349E-1
 2 200
6 M9657 Genes down-regulated in CD4 [GeneID=920] T helper cells (60h): Th0 versus TGFB1 and IL6 [GeneID=7040;3569]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.346E-2
2.197E-1
4.349E-1
 2 200
7 M4268 Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 10 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.346E-2
2.197E-1
4.349E-1
 2 200
8 M7832 Genes up-regulated in amplified multipotent progenitors versus cultured untreated common dendritic cell progenitors. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.346E-2
2.197E-1
4.349E-1
 2 200
9 M8080 Genes up-regulated in lymph node CD4 [GeneID=920] T cells: scurfy (non-functional form of FOXP3 [GeneID=50943]) versus scurfy and IL2 [GeneID=3558] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.346E-2
2.197E-1
4.349E-1
 2 200
10 M6774 Genes down-regulated in splenic DEC205+ dendritic cells versus CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.346E-2
2.197E-1
4.349E-1
 2 200
11 M9499 Genes up-regulated in CD8 T cells: naïve versus effectors at day 15 after acute infection with LCMV-Armstrong. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.346E-2
2.197E-1
4.349E-1
 2 200
12 M6935 Genes down-regulated in B lymphocytes: anti IgM versus anti IgM and CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.346E-2
2.197E-1
4.349E-1
 2 200
13 M3157 Genes down-regulated in comparison of T follicular helper (Tfh) cells versus Th17 cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.346E-2
2.197E-1
4.349E-1
 2 200
14 M1757 Genes up-regulated after Cre-lox knockout of APC [GeneID=324] in the small intestine that require functional MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.201E-3 3.422E-2
2.247E-1
4.791E-1
 2 210
Show 9 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 221 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 1000 K2 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 1.300E-4 2.872E-2
1.717E-1
 2.872E-2 2 65

15: Computational [Display Chart] 4 input genes in category / 30 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 6 input genes in category / 59 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-let-7d*:mirSVR highEffct hsa-let-7d*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.080E-4 6.370E-3 2.970E-2 6.370E-3 2 195
2 hsa-miR-1915*:mirSVR highEffct hsa-miR-1915*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.993E-4 1.357E-2
6.329E-2
 3.536E-2 2 461
3 hsa-miR-3147:mirSVR highEffct hsa-miR-3147:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.902E-4 1.357E-2
6.329E-2
 4.072E-2 2 495
4 hsa-miR-374c-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.986E-3 4.024E-2
1.877E-1
1.762E-1
 1 36
5 hsa-miR-652-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.483E-3 4.024E-2
1.877E-1
2.055E-1
 1 42
6 hsa-miR-942-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 4.024E-2
1.877E-1
3.373E-1
 1 69
7 hsa-miR-4717-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.461E-3 4.024E-2
1.877E-1
3.812E-1
 1 78
8 hsa-miR-4266:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.782E-3 4.024E-2
1.877E-1
4.591E-1
 1 94
9 hsa-miR-889-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.689E-3 4.024E-2
1.877E-1
5.127E-1
 1 105
10 hsa-miR-941:mirSVR highEffct hsa-miR-941:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.689E-3 4.024E-2
1.877E-1
5.127E-1
 1 105
11 hsa-miR-6823-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.184E-3 4.024E-2
1.877E-1
5.419E-1
 1 111
12 hsa-miR-599:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.184E-3 4.024E-2
1.877E-1
5.419E-1
 1 111
13 hsa-miR-4738-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.267E-3 4.024E-2
1.877E-1
5.467E-1
 1 112
14 hsa-miR-6827-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.926E-3 4.024E-2
1.877E-1
5.856E-1
 1 120
15 hsa-miR-3191:mirSVR highEffct hsa-miR-3191:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.042E-2 4.024E-2
1.877E-1
6.148E-1
 1 126
16 hsa-miR-340-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.091E-2 4.024E-2
1.877E-1
6.439E-1
 1 132
17 hsa-miR-3675-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.281E-2 4.027E-2
1.878E-1
7.555E-1
 1 155
18 hsa-let-7i*:mirSVR highEffct hsa-let-7i*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.281E-2 4.027E-2
1.878E-1
7.555E-1
 1 155
19 hsa-miR-1282:mirSVR highEffct hsa-miR-1282:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.297E-2 4.027E-2
1.878E-1
7.652E-1
 1 157
20 hsa-miR-548as-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.428E-2 4.066E-2
1.896E-1
8.427E-1
 1 173
21 hsa-miR-1307:mirSVR lowEffct hsa-miR-1307:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.527E-2 4.066E-2
1.896E-1
9.008E-1
 1 185
22 hsa-miR-614:mirSVR highEffct hsa-miR-614:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.691E-2 4.066E-2
1.896E-1
9.975E-1
 1 205
23 hsa-miR-31-5p:Functional MTI Functional MTI miRTarbase 1.846E-2 4.066E-2
1.896E-1
1.000E0
 1 224
24 hsa-miR-5690:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.871E-2 4.066E-2
1.896E-1
1.000E0
 1 227
25 hsa-miR-6771-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.099E-2 4.066E-2
1.896E-1
1.000E0
 1 255
26 hsa-let-7e*:mirSVR lowEffct hsa-let-7e*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.108E-2 4.066E-2
1.896E-1
1.000E0
 1 256
27 hsa-miR-671-3p:mirSVR lowEffct hsa-miR-671-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.222E-2 4.066E-2
1.896E-1
1.000E0
 1 270
28 hsa-miR-4779:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.360E-2 4.066E-2
1.896E-1
1.000E0
 1 287
29 hsa-miR-5692a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.377E-2 4.066E-2
1.896E-1
1.000E0
 1 289
30 hsa-miR-4684-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.401E-2 4.066E-2
1.896E-1
1.000E0
 1 292
31 hsa-miR-342-3p:Functional MTI Functional MTI miRTarbase 2.499E-2 4.066E-2
1.896E-1
1.000E0
 1 304
32 hsa-miR-181a*:mirSVR lowEffct hsa-miR-181a*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.547E-2 4.066E-2
1.896E-1
1.000E0
 1 310
33 hsa-miR-450a:mirSVR highEffct hsa-miR-450a:mirSVR conserved highEffect-0.5 MicroRNA.org 2.620E-2 4.066E-2
1.896E-1
1.000E0
 1 319
34 hsa-miR-10a*:mirSVR highEffct hsa-miR-10a*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.726E-2 4.066E-2
1.896E-1
1.000E0
 1 332
35 hsa-miR-891a:mirSVR lowEffct hsa-miR-891a:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.775E-2 4.066E-2
1.896E-1
1.000E0
 1 338
36 hsa-miR-3163:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.807E-2 4.066E-2
1.896E-1
1.000E0
 1 342
37 hsa-miR-191:mirSVR highEffct hsa-miR-191:mirSVR conserved highEffect-0.5 MicroRNA.org 2.864E-2 4.066E-2
1.896E-1
1.000E0
 1 349
38 hsa-miR-601:mirSVR highEffct hsa-miR-601:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.115E-2 4.066E-2
1.896E-1
1.000E0
 1 380
39 hsa-miR-155-5p:TargetScan hsa-miR-155-5p TargetScan 3.172E-2 4.066E-2
1.896E-1
1.000E0
 1 387
40 hsa-miR-222-3p:Functional MTI Functional MTI miRTarbase 3.228E-2 4.066E-2
1.896E-1
1.000E0
 1 394
41 hsa-miR-423-3p:mirSVR lowEffct hsa-miR-423-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.261E-2 4.066E-2
1.896E-1
1.000E0
 1 398
42 hsa-miR-621:mirSVR highEffct hsa-miR-621:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.277E-2 4.066E-2
1.896E-1
1.000E0
 1 400
43 hsa-miR-609:mirSVR highEffct hsa-miR-609:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.615E-2 4.066E-2
1.896E-1
1.000E0
 1 442
44 hsa-miR-4296:mirSVR highEffct hsa-miR-4296:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.624E-2 4.066E-2
1.896E-1
1.000E0
 1 443
45 hsa-miR-668:mirSVR highEffct hsa-miR-668:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.632E-2 4.066E-2
1.896E-1
1.000E0
 1 444
46 hsa-miR-1915:mirSVR highEffct hsa-miR-1915:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.640E-2 4.066E-2
1.896E-1
1.000E0
 1 445
47 hsa-miR-4265:mirSVR highEffct hsa-miR-4265:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.664E-2 4.066E-2
1.896E-1
1.000E0
 1 448
48 hsa-miR-103-as:mirSVR highEffct hsa-miR-103-as:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.744E-2 4.066E-2
1.896E-1
1.000E0
 1 458
49 hsa-miR-1274b:mirSVR highEffct hsa-miR-1274b:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.784E-2 4.066E-2
1.896E-1
1.000E0
 1 463
50 hsa-miR-4322:mirSVR highEffct hsa-miR-4322:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.841E-2 4.066E-2
1.896E-1
1.000E0
 1 470
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 373 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID004369394 AR E Stitch 9.768E-13 3.643E-10 2.368E-9 3.643E-10 6 230
2 CID000004607 Bactocill Stitch 1.735E-8 3.235E-6 2.103E-5 6.470E-6 4 135
3 1607 DN Methylergometrine maleate [113-42-8]; Down 200; 8.8uM; HL60; HG-U133A Broad Institute CMAP Down 8.254E-6 6.607E-4 4.294E-3 3.079E-3 3 172
4 3141 DN Dimaprit dihydrochloride [23256-33-9]; Down 200; 17uM; HL60; HT HG-U133A Broad Institute CMAP Down 9.779E-6 6.607E-4 4.294E-3 3.647E-3 3 182
5 1393 DN Nocodazole [31430-18-9]; Down 200; 13.2uM; HL60; HG-U133A Broad Institute CMAP Down 1.010E-5 6.607E-4 4.294E-3 3.769E-3 3 184
6 1745 DN Dihydroergocristine mesylate [24730-10-7]; Down 200; 5.6uM; HL60; HG-U133A Broad Institute CMAP Down 1.078E-5 6.607E-4 4.294E-3 4.020E-3 3 188
7 CID000007870 2-methyl-2,4-pentanediol Stitch 1.240E-5 6.607E-4 4.294E-3 4.625E-3 3 197
8 CID000017472 hexaethylene glycol Stitch 3.408E-5 1.581E-3 1.028E-2 1.271E-2 2 35
9 CID003035294 P-79 Stitch 3.814E-5 1.581E-3 1.028E-2 1.423E-2 2 37
10 CID000000290 AC1Q6S1N Stitch 2.434E-4 9.079E-3
5.902E-2
9.079E-2
 2 93
11 CID000094273 dechlorogriseofulvin Stitch 5.253E-4 1.306E-2
8.487E-2
1.959E-1
 1 2
12 CID004255180 NSC-409901 Stitch 5.253E-4 1.306E-2
8.487E-2
1.959E-1
 1 2
13 CID000017957 P-14 Stitch 8.290E-4 1.306E-2
8.487E-2
3.092E-1
 2 172
14 2938 DN Alprostadil [745-65-3]; Down 200; 11.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 8.580E-4 1.306E-2
8.487E-2
3.200E-1
 2 175
15 2977 DN (-)-Quinpirole hydrochloride [85760-74-3]; Down 200; 15.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 8.874E-4 1.306E-2
8.487E-2
3.310E-1
 2 178
16 2136 DN Dihydroergotoxine mesylate [8067-24-1]; Down 200; 6.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 9.174E-4 1.306E-2
8.487E-2
3.422E-1
 2 181
17 1786 DN Chelidonine monohydrate (+) [476-32-4]; Down 200; 10.8uM; HL60; HG-U133A Broad Institute CMAP Down 9.174E-4 1.306E-2
8.487E-2
3.422E-1
 2 181
18 2403 DN Pergolide mesylate [66104-23-2]; Down 200; 9.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 9.174E-4 1.306E-2
8.487E-2
3.422E-1
 2 181
19 1555 DN Clonidine hydrochloride [4205-91-8]; Down 200; 15uM; HL60; HG-U133A Broad Institute CMAP Down 9.683E-4 1.306E-2
8.487E-2
3.612E-1
 2 186
20 6190 DN 15d-PGJ2; Down 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP Down 9.787E-4 1.306E-2
8.487E-2
3.650E-1
 2 187
21 1159 DN 17-AAG; Down 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP Down 9.995E-4 1.306E-2
8.487E-2
3.728E-1
 2 189
22 6149 DN (-)-Isoproterenol hydrochloride [5984-95-2]; Down 200; 16.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.021E-3 1.306E-2
8.487E-2
3.807E-1
 2 191
23 6166 DN 17-AAG; Down 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.031E-3 1.306E-2
8.487E-2
3.847E-1
 2 192
24 2507 DN Tetrahydrozoline hydrochloride [522-48-5]; Down 200; 16.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.031E-3 1.306E-2
8.487E-2
3.847E-1
 2 192
25 1773 DN Chrysene-1,4-quinone [100900-16-1]; Down 200; 15.4uM; HL60; HG-U133A Broad Institute CMAP Down 1.042E-3 1.306E-2
8.487E-2
3.886E-1
 2 193
26 1653 DN geldanamycin; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.042E-3 1.306E-2
8.487E-2
3.886E-1
 2 193
27 CID000516530 7-P2 Stitch 1.050E-3 1.306E-2
8.487E-2
3.918E-1
 1 4
28 2686 DN 17-AAG; Down 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.053E-3 1.306E-2
8.487E-2
3.926E-1
 2 194
29 1854 DN Betazole hydrochloride; Down 200; 27uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.074E-3 1.306E-2
8.487E-2
4.007E-1
 2 196
30 1589 DN Dobutamine hydrochloride [49745-95-1]; Down 200; 11.8uM; HL60; HG-U133A Broad Institute CMAP Down 1.085E-3 1.306E-2
8.487E-2
4.048E-1
 2 197
31 1742 DN Scoulerine [6451-73-6]; Down 200; 12.2uM; HL60; HG-U133A Broad Institute CMAP Down 1.085E-3 1.306E-2
8.487E-2
4.048E-1
 2 197
32 CID005284648 3'-hydroxydaidzein Stitch 2.362E-3 2.753E-2
1.790E-1
8.811E-1
 1 9
33 CID005486848 8-chloro-3',4',5,7-tetrahydroxyisoflavone Stitch 2.624E-3 2.966E-2
1.928E-1
9.789E-1
 1 10
34 CID006603857 GW2974 Stitch 2.886E-3 3.167E-2
2.058E-1
1.000E0
 1 11
35 CID000000761 5'-GMP Na2 Stitch 3.094E-3 3.297E-2
2.143E-1
1.000E0
 2 335
36 CID000056603 P 14 Stitch 3.410E-3 3.534E-2
2.297E-1
1.000E0
 1 13
37 CID000092377 ABPH Stitch 3.672E-3 3.702E-2
2.406E-1
1.000E0
 1 14
38 CID000444230 N-V-I Stitch 4.196E-3 4.119E-2
2.677E-1
1.000E0
 1 16
39 CID011957380 DB07105 Stitch 4.458E-3 4.264E-2
2.771E-1
1.000E0
 1 17
40 CID000003835 AC1L1GTN Stitch 4.720E-3 4.294E-2
2.791E-1
1.000E0
 1 18
41 CID000405731 im b Stitch 4.720E-3 4.294E-2
2.791E-1
1.000E0
 1 18
42 CID000010606 pyranocoumarin Stitch 5.504E-3 4.888E-2
3.178E-1
1.000E0
 1 21
Show 37 more annotations

18: Disease [Display Chart] 5 input genes in category / 33 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 cv:CN221091 Pontocerebellar hypoplasia, type 1c Clinical Variations 3.085E-4 5.091E-3 2.082E-2 1.018E-2 1 1
2 C4015160 PONTOCEREBELLAR HYPOPLASIA, TYPE 1C DisGeNET Curated 3.085E-4 5.091E-3 2.082E-2 1.018E-2 1 1
3 C1843504 Pontocerebellar Hypoplasia Type 1 DisGeNET Curated 1.542E-3 1.696E-2
6.935E-2
5.089E-2
 1 5
4 C0278787 relapsing chronic myelogenous leukemia DisGeNET BeFree 2.466E-3 2.035E-2
8.319E-2
8.139E-2
 1 8
5 C0575059 Spastic tetraparesis DisGeNET Curated 4.313E-3 2.372E-2
9.699E-2
1.423E-1
 1 14
6 C1401084 Ovarian Insufficiency DisGeNET BeFree 4.313E-3 2.372E-2
9.699E-2
1.423E-1
 1 14
7 C1840379 Cerebellar vermis hypoplasia DisGeNET Curated 7.384E-3 3.481E-2
1.423E-1
2.437E-1
 1 24
8 C0747102 Ovarian failure DisGeNET BeFree 1.228E-2 4.616E-2
1.887E-1
4.053E-1
 1 40
9 C0242621 Isochromosomes DisGeNET BeFree 1.259E-2 4.616E-2
1.887E-1
4.154E-1
 1 41
10 C1839780 FRAGILE X TREMOR/ATAXIA SYNDROME DisGeNET Curated 1.411E-2 4.658E-2
1.904E-1
4.658E-1
 1 46
Show 5 more annotations