Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc202_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 34 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters 5.580E-5 8.560E-4 3.525E-3 1.897E-3 2 31
2 GO:0042162 telomeric DNA binding 5.580E-5 8.560E-4 3.525E-3 1.897E-3 2 31
3 GO:0004532 exoribonuclease activity 7.553E-5 8.560E-4 3.525E-3 2.568E-3 2 36
4 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.349E-4 1.147E-3 4.724E-3 4.588E-3 2 48
5 GO:0004527 exonuclease activity 3.949E-4 2.685E-3 1.106E-2 1.343E-2 2 82
6 GO:0004540 ribonuclease activity 6.223E-4 3.526E-3 1.452E-2 2.116E-2 2 103
7 GO:0003729 mRNA binding 1.862E-3 7.966E-3 3.281E-2
6.330E-2
 2 179
8 GO:0050815 phosphoserine residue binding 1.874E-3 7.966E-3 3.281E-2
6.373E-2
 1 5
9 GO:0050072 m7G(5')pppN diphosphatase activity 2.998E-3 1.037E-2 4.270E-2
1.019E-1
 1 8
10 GO:0004518 nuclease activity 3.049E-3 1.037E-2 4.270E-2
1.037E-1
 2 230
11 GO:0004535 poly(A)-specific ribonuclease activity 4.493E-3 1.389E-2
5.720E-2
1.528E-1
 1 12
12 GO:0004697 protein kinase C activity 8.970E-3 2.541E-2
1.047E-1
3.050E-1
 1 24
13 GO:0045309 protein phosphorylated amino acid binding 1.046E-2 2.720E-2
1.120E-1
3.556E-1
 1 28
14 GO:0000175 3'-5'-exoribonuclease activity 1.120E-2 2.720E-2
1.120E-1
3.808E-1
 1 30
15 GO:0030145 manganese ion binding 1.898E-2 3.869E-2
1.593E-1
6.452E-1
 1 51
16 GO:0008408 3'-5' exonuclease activity 1.935E-2 3.869E-2
1.593E-1
6.578E-1
 1 52
17 GO:0003730 mRNA 3'-UTR binding 1.935E-2 3.869E-2
1.593E-1
6.578E-1
 1 52
18 GO:0004004 ATP-dependent RNA helicase activity 2.450E-2 4.384E-2
1.806E-1
8.330E-1
 1 66
19 GO:0008186 RNA-dependent ATPase activity 2.450E-2 4.384E-2
1.806E-1
8.330E-1
 1 66
20 GO:0003724 RNA helicase activity 2.780E-2 4.679E-2
1.927E-1
9.452E-1
 1 75
21 GO:0051219 phosphoprotein binding 2.890E-2 4.679E-2
1.927E-1
9.826E-1
 1 78
Show 16 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 203 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 5.846E-8 8.904E-6 5.247E-5 1.187E-5 4 121
2 GO:0043488 regulation of mRNA stability 1.179E-7 8.904E-6 5.247E-5 2.393E-5 4 144
3 GO:0043487 regulation of RNA stability 1.316E-7 8.904E-6 5.247E-5 2.671E-5 4 148
4 GO:0010608 posttranscriptional regulation of gene expression 2.128E-7 1.080E-5 6.365E-5 4.321E-5 5 475
5 GO:0000956 nuclear-transcribed mRNA catabolic process 4.585E-7 1.861E-5 1.097E-4 9.307E-5 4 202
6 GO:0006402 mRNA catabolic process 6.220E-7 2.104E-5 1.240E-4 1.263E-4 4 218
7 GO:0006401 RNA catabolic process 1.025E-6 2.971E-5 1.751E-4 2.080E-4 4 247
8 GO:0034655 nucleobase-containing compound catabolic process 8.300E-6 2.106E-4 1.241E-3 1.685E-3 4 418
9 GO:0071044 histone mRNA catabolic process 1.100E-5 2.309E-4 1.360E-3 2.232E-3 2 14
10 GO:0044270 cellular nitrogen compound catabolic process 1.233E-5 2.309E-4 1.360E-3 2.503E-3 4 462
11 GO:0046700 heterocycle catabolic process 1.254E-5 2.309E-4 1.360E-3 2.547E-3 4 464
12 GO:0019439 aromatic compound catabolic process 1.365E-5 2.309E-4 1.360E-3 2.770E-3 4 474
13 GO:0008334 histone mRNA metabolic process 4.557E-5 7.115E-4 4.193E-3 9.250E-3 2 28
14 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic 7.163E-5 1.039E-3 6.121E-3 1.454E-2 2 35
15 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2.726E-4 3.690E-3 2.174E-2
5.535E-2
 2 68
16 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay 7.516E-4 9.536E-3
5.620E-2
1.526E-1
 1 2
17 GO:0070555 response to interleukin-1 9.036E-4 1.079E-2
6.358E-2
1.834E-1
 2 124
18 GO:0090501 RNA phosphodiester bond hydrolysis 9.925E-4 1.119E-2
6.596E-2
2.015E-1
 2 130
19 GO:0051028 mRNA transport 1.335E-3 1.427E-2
8.408E-2
2.711E-1
 2 151
20 GO:0050658 RNA transport 1.869E-3 1.782E-2
1.050E-1
3.794E-1
 2 179
21 GO:0050657 nucleic acid transport 1.869E-3 1.782E-2
1.050E-1
3.794E-1
 2 179
22 GO:0051236 establishment of RNA localization 1.931E-3 1.782E-2
1.050E-1
3.921E-1
 2 182
23 GO:0032201 telomere maintenance via semi-conservative replication 2.253E-3 1.989E-2
1.172E-1
4.575E-1
 1 6
24 GO:0006403 RNA localization 2.657E-3 2.178E-2
1.283E-1
5.394E-1
 2 214
25 GO:0015931 nucleobase-containing compound transport 2.682E-3 2.178E-2
1.283E-1
5.444E-1
 2 215
26 GO:0034351 negative regulation of glial cell apoptotic process 3.004E-3 2.212E-2
1.304E-1
6.097E-1
 1 8
27 GO:0061158 3'-UTR-mediated mRNA destabilization 3.004E-3 2.212E-2
1.304E-1
6.097E-1
 1 8
28 GO:0034350 regulation of glial cell apoptotic process 3.379E-3 2.212E-2
1.304E-1
6.858E-1
 1 9
29 GO:0006449 regulation of translational termination 3.379E-3 2.212E-2
1.304E-1
6.858E-1
 1 9
30 GO:0009048 dosage compensation by inactivation of X chromosome 3.379E-3 2.212E-2
1.304E-1
6.858E-1
 1 9
31 GO:0048194 Golgi vesicle budding 3.379E-3 2.212E-2
1.304E-1
6.858E-1
 1 9
32 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA 3.753E-3 2.381E-2
1.403E-1
7.619E-1
 1 10
33 GO:0007549 dosage compensation 4.128E-3 2.539E-2
1.496E-1
8.380E-1
 1 11
34 GO:0090305 nucleic acid phosphodiester bond hydrolysis 4.252E-3 2.539E-2
1.496E-1
8.632E-1
 2 272
35 GO:0035089 establishment of apical/basal cell polarity 5.251E-3 2.881E-2
1.698E-1
1.000E0
 1 14
36 GO:0061157 mRNA destabilization 5.251E-3 2.881E-2
1.698E-1
1.000E0
 1 14
37 GO:0060252 positive regulation of glial cell proliferation 5.251E-3 2.881E-2
1.698E-1
1.000E0
 1 14
38 GO:0061162 establishment of monopolar cell polarity 6.000E-3 3.081E-2
1.815E-1
1.000E0
 1 16
39 GO:2000353 positive regulation of endothelial cell apoptotic process 6.000E-3 3.081E-2
1.815E-1
1.000E0
 1 16
40 GO:0061339 establishment or maintenance of monopolar cell polarity 6.373E-3 3.081E-2
1.815E-1
1.000E0
 1 17
41 GO:0050779 RNA destabilization 6.373E-3 3.081E-2
1.815E-1
1.000E0
 1 17
42 GO:0034349 glial cell apoptotic process 6.373E-3 3.081E-2
1.815E-1
1.000E0
 1 17
43 GO:0006417 regulation of translation 6.834E-3 3.226E-2
1.901E-1
1.000E0
 2 347
44 GO:0090150 establishment of protein localization to membrane 8.025E-3 3.651E-2
2.152E-1
1.000E0
 2 377
45 GO:0034248 regulation of cellular amide metabolic process 8.149E-3 3.651E-2
2.152E-1
1.000E0
 2 380
46 GO:1903829 positive regulation of cellular protein localization 8.273E-3 3.651E-2
2.152E-1
1.000E0
 2 383
47 GO:0061014 positive regulation of mRNA catabolic process 8.615E-3 3.721E-2
2.193E-1
1.000E0
 1 23
48 GO:0033260 nuclear DNA replication 9.361E-3 3.959E-2
2.333E-1
1.000E0
 1 25
49 GO:0061013 regulation of mRNA catabolic process 9.734E-3 4.032E-2
2.376E-1
1.000E0
 1 26
50 GO:0060251 regulation of glial cell proliferation 1.011E-2 4.103E-2
2.418E-1
1.000E0
 1 27
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 32 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0035145 exon-exon junction complex 2.914E-5 9.325E-4 3.785E-3 9.325E-4 2 23
2 GO:0000932 P-body 2.919E-4 4.670E-3 1.895E-2 9.341E-3 2 72
3 GO:0044530 supraspliceosomal complex 1.101E-3 8.271E-3 3.357E-2 3.524E-2 1 3
4 GO:0036464 cytoplasmic ribonucleoprotein granule 1.161E-3 8.271E-3 3.357E-2 3.715E-2 2 144
5 GO:0035770 ribonucleoprotein granule 1.292E-3 8.271E-3 3.357E-2 4.135E-2 2 152
6 GO:0016442 RISC complex 4.033E-3 1.844E-2
7.483E-2
1.291E-1
 1 11
7 GO:0031332 RNAi effector complex 4.033E-3 1.844E-2
7.483E-2
1.291E-1
 1 11
8 GO:0043220 Schmidt-Lanterman incisure 5.497E-3 2.199E-2
8.923E-2
1.759E-1
 1 15
9 GO:0043218 compact myelin 6.958E-3 2.474E-2
1.004E-1
2.227E-1
 1 19
Show 4 more annotations

4: Human Phenotype [Display Chart] 1 input genes in category / 201 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 4 input genes in category / 175 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0011870 abnormal podocyte polarity 3.863E-4 3.380E-2
1.942E-1
6.760E-2
 1 1
2 MP:0001318 pupil opacity 3.863E-4 3.380E-2
1.942E-1
6.760E-2
 1 1
3 MP:0011864 abnormal podocyte adhesion 1.159E-3 4.156E-2
2.387E-1
2.027E-1
 1 3
4 MP:0011869 detached podocyte 1.159E-3 4.156E-2
2.387E-1
2.027E-1
 1 3
5 MP:0011863 abnormal podocyte physiology 1.544E-3 4.156E-2
2.387E-1
2.703E-1
 1 4
6 MP:0001320 small pupils 1.930E-3 4.156E-2
2.387E-1
3.378E-1
 1 5
7 MP:0030020 decreased cardiac cell glucose uptake 1.930E-3 4.156E-2
2.387E-1
3.378E-1
 1 5
8 MP:0011190 thick embryonic epiblast 2.316E-3 4.156E-2
2.387E-1
4.053E-1
 1 6
9 MP:0012104 small amniotic cavity 2.316E-3 4.156E-2
2.387E-1
4.053E-1
 1 6
10 MP:0005199 abnormal iris pigment epithelium 3.087E-3 4.156E-2
2.387E-1
5.403E-1
 1 8
11 MP:0008583 absent photoreceptor inner segment 3.087E-3 4.156E-2
2.387E-1
5.403E-1
 1 8
12 MP:0011753 decreased podocyte number 3.087E-3 4.156E-2
2.387E-1
5.403E-1
 1 8
13 MP:0011610 abnormal primordial germ cell apoptosis 3.087E-3 4.156E-2
2.387E-1
5.403E-1
 1 8
14 MP:0012081 absent heart tube 3.858E-3 4.178E-2
2.400E-1
6.751E-1
 1 10
15 MP:0011483 renal glomerular synechia 3.858E-3 4.178E-2
2.400E-1
6.751E-1
 1 10
16 MP:0002579 disorganized secondary lens fibers 4.243E-3 4.178E-2
2.400E-1
7.425E-1
 1 11
17 MP:0011509 dilated glomerular capillary 4.628E-3 4.178E-2
2.400E-1
8.099E-1
 1 12
18 MP:0006205 embryonic lethality between implantation and somite formation 4.766E-3 4.178E-2
2.400E-1
8.341E-1
 2 298
19 MP:0009687 empty decidua capsularis 5.013E-3 4.178E-2
2.400E-1
8.773E-1
 1 13
20 MP:0008060 abnormal podocyte slit diaphragm morphology 5.013E-3 4.178E-2
2.400E-1
8.773E-1
 1 13
21 MP:0004559 small allantois 5.013E-3 4.178E-2
2.400E-1
8.773E-1
 1 13
22 MP:0008062 abnormal podocyte slit junction morphology 5.398E-3 4.216E-2
2.422E-1
9.446E-1
 1 14
23 MP:0001705 abnormal proximal-distal axis patterning 5.783E-3 4.216E-2
2.422E-1
1.000E0
 1 15
24 MP:0020326 dilated capillary 5.783E-3 4.216E-2
2.422E-1
1.000E0
 1 15
25 MP:0030017 decreased adipocyte glucose uptake 6.936E-3 4.575E-2
2.628E-1
1.000E0
 1 18
26 MP:0011111 lethality during fetal growth through weaning, complete penetrance 6.936E-3 4.575E-2
2.628E-1
1.000E0
 1 18
27 MP:0011257 abnormal head fold morphology 7.320E-3 4.575E-2
2.628E-1
1.000E0
 1 19
28 MP:0004039 abnormal cardiac cell glucose uptake 7.320E-3 4.575E-2
2.628E-1
1.000E0
 1 19
29 MP:0011199 abnormal amniotic cavity morphology 7.704E-3 4.649E-2
2.671E-1
1.000E0
 1 20
30 MP:0008139 fused podocyte foot processes 8.089E-3 4.718E-2
2.711E-1
1.000E0
 1 21
31 MP:0020815 abnormal photoreceptor outer segment number 8.856E-3 4.843E-2
2.782E-1
1.000E0
 1 23
32 MP:0008585 absent photoreceptor outer segment 8.856E-3 4.843E-2
2.782E-1
1.000E0
 1 23
Show 27 more annotations

6: Domain [Display Chart] 7 input genes in category / 61 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR007722 DCP2 BoxA InterPro 3.736E-4 2.532E-3 1.189E-2 2.279E-2 1 1
2 IPR019532 Nucl RNA-splicing assoc SR-25 InterPro 3.736E-4 2.532E-3 1.189E-2 2.279E-2 1 1
3 PF05026 DCP2 Pfam 3.736E-4 2.532E-3 1.189E-2 2.279E-2 1 1
4 PF08675 RNA bind Pfam 3.736E-4 2.532E-3 1.189E-2 2.279E-2 1 1
5 PF10500 SR-25 Pfam 3.736E-4 2.532E-3 1.189E-2 2.279E-2 1 1
6 SM01125 DCP2 SMART 3.736E-4 2.532E-3 1.189E-2 2.279E-2 1 1
7 PF09416 UPF1 Zn bind Pfam 3.736E-4 2.532E-3 1.189E-2 2.279E-2 1 1
8 IPR014789 PolyA-riboNase RNA binding InterPro 3.736E-4 2.532E-3 1.189E-2 2.279E-2 1 1
9 IPR018999 RNA-helicase UPF1 UPF2-interct InterPro 3.736E-4 2.532E-3 1.189E-2 2.279E-2 1 1
10 IPR012233 PKC InterPro 7.471E-4 3.798E-3 1.784E-2 4.558E-2 1 2
11 IPR005120 Nonsense mediated decay UPF3 InterPro 7.471E-4 3.798E-3 1.784E-2 4.558E-2 1 2
12 PF03467 Smg4 UPF3 Pfam 7.471E-4 3.798E-3 1.784E-2 4.558E-2 1 2
13 PF04857 CAF1 Pfam 1.867E-3 7.919E-3 3.719E-2
1.139E-1
 1 5
14 IPR006941 RNase CAF1 InterPro 1.867E-3 7.919E-3 3.719E-2
1.139E-1
 1 5
15 PF00244 14-3-3 Pfam 2.613E-3 7.919E-3 3.719E-2
1.594E-1
 1 7
16 IPR023410 14-3-3 domain InterPro 2.613E-3 7.919E-3 3.719E-2
1.594E-1
 1 7
17 PS00797 1433 2 PROSITE 2.613E-3 7.919E-3 3.719E-2
1.594E-1
 1 7
18 IPR023409 14-3-3 CS InterPro 2.613E-3 7.919E-3 3.719E-2
1.594E-1
 1 7
19 PS00796 1433 1 PROSITE 2.613E-3 7.919E-3 3.719E-2
1.594E-1
 1 7
20 SM00101 14 3 3 SMART 2.613E-3 7.919E-3 3.719E-2
1.594E-1
 1 7
21 IPR000308 14-3-3 InterPro 2.986E-3 7.919E-3 3.719E-2
1.821E-1
 1 8
22 IPR006935 Helicase/UvrB N InterPro 2.986E-3 7.919E-3 3.719E-2
1.821E-1
 1 8
23 PF04851 ResIII Pfam 2.986E-3 7.919E-3 3.719E-2
1.821E-1
 1 8
24 3.30.70.330 - Gene3D 3.398E-3 8.631E-3 4.053E-2
2.073E-1
 2 244
25 IPR012677 Nucleotide-bd a/b plait InterPro 3.790E-3 8.631E-3 4.053E-2
2.312E-1
 2 258
26 PS51061 R3H PROSITE 4.103E-3 8.631E-3 4.053E-2
2.503E-1
 1 11
27 PF01424 R3H Pfam 4.103E-3 8.631E-3 4.053E-2
2.503E-1
 1 11
28 3.30.1370.50 - Gene3D 4.103E-3 8.631E-3 4.053E-2
2.503E-1
 1 11
29 IPR001374 R3H dom InterPro 4.103E-3 8.631E-3 4.053E-2
2.503E-1
 1 11
30 IPR020084 NUDIX hydrolase CS InterPro 4.476E-3 9.101E-3 4.274E-2
2.730E-1
 1 12
31 PF00564 PB1 Pfam 5.220E-3 9.365E-3 4.398E-2
3.184E-1
 1 14
32 SM00666 PB1 SMART 5.220E-3 9.365E-3 4.398E-2
3.184E-1
 1 14
33 PS51745 PB1 PROSITE 5.220E-3 9.365E-3 4.398E-2
3.184E-1
 1 14
34 IPR000270 PB1 dom InterPro 5.220E-3 9.365E-3 4.398E-2
3.184E-1
 1 14
35 IPR020454 DAG/PE-bd InterPro 7.821E-3 1.363E-2
6.402E-2
4.771E-1
 1 21
36 PS00893 NUDIX BOX PROSITE 8.934E-3 1.473E-2
6.917E-2
5.450E-1
 1 24
37 PF00293 NUDIX Pfam 8.934E-3 1.473E-2
6.917E-2
5.450E-1
 1 24
38 PS51462 NUDIX PROSITE 9.676E-3 1.553E-2
7.294E-2
5.902E-1
 1 26
39 3.90.79.10 - Gene3D 1.042E-2 1.589E-2
7.460E-2
6.354E-1
 1 28
40 IPR015797 NUDIX hydrolase dom-like InterPro 1.042E-2 1.589E-2
7.460E-2
6.354E-1
 1 28
41 IPR000086 NUDIX hydrolase dom InterPro 1.079E-2 1.605E-2
7.537E-2
6.580E-1
 1 29
42 IPR017892 Pkinase C InterPro 1.374E-2 1.996E-2
9.375E-2
8.384E-1
 1 37
43 PF00433 Pkinase C Pfam 1.559E-2 2.212E-2
1.039E-1
9.510E-1
 1 42
44 3.30.420.10 - Gene3D 1.743E-2 2.417E-2
1.135E-1
1.000E0
 1 47
45 SM00133 S TK X SMART 2.074E-2 2.682E-2
1.260E-1
1.000E0
 1 56
46 PS51285 AGC KINASE CTER PROSITE 2.074E-2 2.682E-2
1.260E-1
1.000E0
 1 56
47 IPR000961 AGC-kinase C InterPro 2.074E-2 2.682E-2
1.260E-1
1.000E0
 1 56
48 PF00130 C1 1 Pfam 2.111E-2 2.682E-2
1.260E-1
1.000E0
 1 57
49 PS00479 ZF DAG PE 1 PROSITE 2.367E-2 2.863E-2
1.344E-1
1.000E0
 1 64
50 PS50081 ZF DAG PE 2 PROSITE 2.367E-2 2.863E-2
1.344E-1
1.000E0
 1 64
Show 45 more annotations

7: Pathway [Display Chart] 6 input genes in category / 139 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269725 Regulation of mRNA stability by proteins that bind AU-rich elements BioSystems: REACTOME 7.941E-6 1.104E-3 6.087E-3 1.104E-3 3 93
2 1269727 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA BioSystems: REACTOME 2.951E-5 1.146E-3 6.321E-3 4.102E-3 2 18
3 1269728 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA BioSystems: REACTOME 2.951E-5 1.146E-3 6.321E-3 4.102E-3 2 18
4 1269729 KSRP (KHSRP) binds and destabilizes mRNA BioSystems: REACTOME 3.298E-5 1.146E-3 6.321E-3 4.584E-3 2 19
5 1268762 ATF4 activates genes BioSystems: REACTOME 6.758E-5 1.662E-3 9.166E-3 9.393E-3 2 27
6 137981 Insulin-mediated glucose transport BioSystems: Pathway Interaction Database 7.813E-5 1.662E-3 9.166E-3 1.086E-2 2 29
7 1268761 PERK regulates gene expression BioSystems: REACTOME 8.370E-5 1.662E-3 9.166E-3 1.163E-2 2 30
8 1269712 Deadenylation-dependent mRNA decay BioSystems: REACTOME 3.053E-4 5.305E-3 2.926E-2 4.244E-2 2 57
9 117291 RNA degradation BioSystems: KEGG 5.573E-4 8.607E-3 4.747E-2
7.747E-2
 2 77
10 193328 mRNA surveillance pathway BioSystems: KEGG 7.776E-4 1.026E-2
5.659E-2
1.081E-1
 2 91
11 1268756 Unfolded Protein Response (UPR) BioSystems: REACTOME 8.120E-4 1.026E-2
5.659E-2
1.129E-1
 2 93
12 P00021 FGF signaling pathway PantherDB 9.759E-4 1.130E-2
6.234E-2
1.356E-1
 2 102
13 P00018 EGF receptor signaling pathway PantherDB 1.154E-3 1.234E-2
6.807E-2
1.605E-1
 2 111
14 1269716 Nonsense-Mediated Decay (NMD) BioSystems: REACTOME 1.370E-3 1.269E-2
7.001E-2
1.904E-1
 2 121
15 1269717 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) BioSystems: REACTOME 1.370E-3 1.269E-2
7.001E-2
1.904E-1
 2 121
16 749777 Hippo signaling pathway BioSystems: KEGG 2.207E-3 1.917E-2
1.058E-1
3.068E-1
 2 154
17 177876 RNA transport BioSystems: KEGG 2.713E-3 2.218E-2
1.223E-1
3.771E-1
 2 171
18 1269755 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex BioSystems: REACTOME 5.770E-3 4.456E-2
2.458E-1
8.021E-1
 1 12
19 1269453 p75NTR recruits signalling complexes BioSystems: REACTOME 6.729E-3 4.771E-2
2.632E-1
9.354E-1
 1 14
20 1269715 mRNA decay by 5' to 3' exoribonuclease BioSystems: REACTOME 7.209E-3 4.771E-2
2.632E-1
1.000E0
 1 15
21 1270271 Activation of BAD and translocation to mitochondria BioSystems: REACTOME 7.209E-3 4.771E-2
2.632E-1
1.000E0
 1 15
22 1269202 Rap1 signalling BioSystems: REACTOME 7.688E-3 4.857E-2
2.679E-1
1.000E0
 1 16
23 1269452 p75NTR signals via NF-kB BioSystems: REACTOME 8.166E-3 4.935E-2
2.722E-1
1.000E0
 1 17
Show 18 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 934 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14527413 Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Pubmed 1.953E-13 1.825E-10 1.353E-9 1.825E-10 4 12
2 12417715 Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Pubmed 1.319E-10 6.160E-8 4.569E-7 1.232E-7 3 7
3 17803942 Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm. Pubmed 8.637E-8 2.017E-5 1.496E-4 8.067E-5 2 3
4 22890540 New azaphilones and chlorinated phenolic glycosides from Chaetomium elatum with caspase-3 inhibitory activity. Pubmed 8.637E-8 2.017E-5 1.496E-4 8.067E-5 2 3
5 19503078 A UPF3-mediated regulatory switch that maintains RNA surveillance. Pubmed 1.727E-7 2.017E-5 1.496E-4 1.613E-4 2 4
6 11113196 Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Pubmed 1.727E-7 2.017E-5 1.496E-4 1.613E-4 2 4
7 21541368 A yeast model of FUS/TLS-dependent cytotoxicity. Pubmed 1.727E-7 2.017E-5 1.496E-4 1.613E-4 2 4
8 11544179 Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Pubmed 1.727E-7 2.017E-5 1.496E-4 1.613E-4 2 4
9 15231747 A protein interaction framework for human mRNA degradation. Pubmed 2.294E-7 2.381E-5 1.766E-4 2.143E-4 4 347
10 11163187 Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Pubmed 2.879E-7 2.444E-5 1.813E-4 2.689E-4 2 5
11 12723973 Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. Pubmed 2.879E-7 2.444E-5 1.813E-4 2.689E-4 2 5
12 12554878 Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. Pubmed 4.318E-7 2.880E-5 2.136E-4 4.033E-4 2 6
13 23821644 The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth. Pubmed 4.318E-7 2.880E-5 2.136E-4 4.033E-4 2 6
14 15324659 aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. Pubmed 4.318E-7 2.880E-5 2.136E-4 4.033E-4 2 6
15 26950371 Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects. Pubmed 6.044E-7 3.321E-5 2.463E-4 5.645E-4 2 7
16 14636577 Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Pubmed 6.044E-7 3.321E-5 2.463E-4 5.645E-4 2 7
17 17916692 Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Pubmed 6.044E-7 3.321E-5 2.463E-4 5.645E-4 2 7
18 16601204 Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. Pubmed 8.058E-7 4.181E-5 3.101E-4 7.526E-4 2 8
19 21876179 Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. Pubmed 1.036E-6 4.838E-5 3.588E-4 9.676E-4 2 9
20 16364915 Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Pubmed 1.036E-6 4.838E-5 3.588E-4 9.676E-4 2 9
21 11546874 Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Pubmed 1.295E-6 5.759E-5 4.271E-4 1.209E-3 2 10
22 21145460 Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Pubmed 1.899E-6 8.061E-5 5.979E-4 1.773E-3 2 12
23 16452507 Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Pubmed 2.617E-6 1.063E-4 7.884E-4 2.445E-3 2 14
24 27926873 FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3. Pubmed 9.287E-6 3.614E-4 2.681E-3 8.674E-3 3 248
25 25036637 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Pubmed 2.103E-5 7.855E-4 5.826E-3 1.964E-2 3 326
26 23444366 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. Pubmed 2.470E-5 8.875E-4 6.583E-3 2.307E-2 2 42
27 14676191 Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. Pubmed 6.716E-5 9.057E-4 6.718E-3
6.272E-2
 2 69
28 17979178 A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Pubmed 1.069E-4 9.057E-4 6.718E-3
9.986E-2
 2 87
29 26253027 Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
30 17785461 A multifunctional RNA recognition motif in poly(A)-specific ribonuclease with cap and poly(A) binding properties. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
31 18694759 Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
32 29912646 MicroRNA-141-3p/200a-3p target and may be involved in post-transcriptional repression of RNA decapping enzyme Dcp2 during renal development. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
33 21598387 Identification of 14-3-3β in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
34 19327373 Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
35 24174471 PKCι maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
36 12923261 Functional characterization of the mammalian mRNA decapping enzyme hDcp2. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
37 12896901 Forced expression of antisense 14-3-3beta RNA suppresses tumor cell growth in vitro and in vivo. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
38 7607695 Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
39 11742007 Identification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe(2+)-mediated cleavage. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
40 15240115 Dominant negative 14-3-3 promotes cardiomyocyte apoptosis in early stage of type I diabetes mellitus through activation of JNK. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
41 20945390 Protein kinase Cι expression and oncogenic signaling mechanisms in cancer. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
42 16281054 Structural insight into poly(A) binding and catalytic mechanism of human PARN. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
43 26482878 Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
44 11884129 An SR-protein induced by HSVI binding to cells functioning as a splicing inhibitor of viral pre-mRNA. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
45 18628308 aPKC enables development of zonula adherens by antagonizing centripetal contraction of the circumferential actomyosin cables. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
46 20445233 Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
47 16125198 Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
48 19704008 Human UPF1 participates in small RNA-induced mRNA downregulation. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
49 12815264 Rapid backbone 1H, 13C, and 15N assignment of the V1 domain of human PKC iota using the new program IBIS. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
50 22817733 UPF1 involvement in nuclear functions. Pubmed 1.833E-4 9.057E-4 6.718E-3
1.712E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 796 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:UPF3A UPF3A interactions 7.781E-10 6.193E-7 4.495E-6 6.193E-7 4 40
2 int:UPF2 UPF2 interactions 2.807E-8 1.117E-5 8.107E-5 2.234E-5 4 96
3 int:PARN PARN interactions 6.682E-8 1.773E-5 1.287E-4 5.319E-5 3 23
4 int:SMG1 SMG1 interactions 2.688E-7 5.349E-5 3.882E-4 2.140E-4 3 36
5 int:EDC3 EDC3 interactions 1.418E-6 1.887E-4 1.370E-3 1.128E-3 3 62
6 int:UPF1 UPF1 interactions 1.423E-6 1.887E-4 1.370E-3 1.132E-3 4 255
7 int:DCP2 DCP2 interactions 1.794E-6 2.040E-4 1.481E-3 1.428E-3 3 67
8 int:ZFP36L1 ZFP36L1 interactions 2.284E-5 2.273E-3 1.650E-2 1.818E-2 2 19
9 int:RNPS1 RNPS1 interactions 5.405E-5 4.780E-3 3.469E-2 4.302E-2 3 208
10 int:MTMR4 MTMR4 interactions 1.201E-4 9.559E-3
6.938E-2
9.559E-2
 2 43
11 int:FOXA1 FOXA1 interactions 1.510E-4 1.079E-2
7.833E-2
1.202E-1
 3 294
12 int:UPF3B UPF3B interactions 1.627E-4 1.079E-2
7.833E-2
1.295E-1
 2 50
13 int:BAD BAD interactions 2.192E-4 1.165E-2
8.455E-2
1.745E-1
 2 58
14 int:MARK4 MARK4 interactions 2.269E-4 1.165E-2
8.455E-2
1.806E-1
 2 59
15 int:NIPSNAP2 NIPSNAP2 interactions 2.269E-4 1.165E-2
8.455E-2
1.806E-1
 2 59
16 int:DCP1A DCP1A interactions 2.346E-4 1.165E-2
8.455E-2
1.868E-1
 2 60
17 int:WWC1 WWC1 interactions 2.671E-4 1.165E-2
8.455E-2
2.126E-1
 2 64
18 int:ZFP36 ZFP36 interactions 2.671E-4 1.165E-2
8.455E-2
2.126E-1
 2 64
19 int:KIF23 KIF23 interactions 2.840E-4 1.165E-2
8.455E-2
2.261E-1
 2 66
20 int:HBB HBB interactions 2.927E-4 1.165E-2
8.455E-2
2.330E-1
 2 67
21 int:PARD3 PARD3 interactions 4.384E-4 1.571E-2
1.140E-1
3.490E-1
 2 82
22 int:EXOSC10 EXOSC10 interactions 4.600E-4 1.571E-2
1.140E-1
3.662E-1
 2 84
23 int:PARD6B PARD6B interactions 4.822E-4 1.571E-2
1.140E-1
3.838E-1
 2 86
24 int:PLEKHA5 PLEKHA5 interactions 4.934E-4 1.571E-2
1.140E-1
3.928E-1
 2 87
25 int:EXOSC2 EXOSC2 interactions 4.934E-4 1.571E-2
1.140E-1
3.928E-1
 2 87
26 int:EDC4 EDC4 interactions 5.880E-4 1.734E-2
1.258E-1
4.681E-1
 2 95
27 int:RNF41 RNF41 interactions 5.880E-4 1.734E-2
1.258E-1
4.681E-1
 2 95
28 int:MIR15B MIR15B interactions 6.907E-4 1.964E-2
1.425E-1
5.498E-1
 2 103
29 int:MARK2 MARK2 interactions 7.873E-4 2.098E-2
1.523E-1
6.267E-1
 2 110
30 int:INPP5F INPP5F interactions 7.907E-4 2.098E-2
1.523E-1
6.294E-1
 1 2
31 int:RBM8A RBM8A interactions 8.900E-4 2.155E-2
1.564E-1
7.084E-1
 2 117
32 int:POLD1 POLD1 interactions 8.900E-4 2.155E-2
1.564E-1
7.084E-1
 2 117
33 int:EXOSC4 EXOSC4 interactions 9.204E-4 2.155E-2
1.564E-1
7.327E-1
 2 119
34 int:XRN1 XRN1 interactions 9.204E-4 2.155E-2
1.564E-1
7.327E-1
 2 119
35 int:PARP8 PARP8 interactions 1.186E-3 2.622E-2
1.903E-1
9.439E-1
 1 3
36 int:GPR15 GPR15 interactions 1.186E-3 2.622E-2
1.903E-1
9.439E-1
 1 3
37 int:MAP2K1 MAP2K1 interactions 1.362E-3 2.930E-2
2.126E-1
1.000E0
 2 145
38 int:DCAF7 DCAF7 interactions 1.399E-3 2.931E-2
2.127E-1
1.000E0
 2 147
39 int:PDCL2 PDCL2 interactions 1.581E-3 3.227E-2
2.342E-1
1.000E0
 1 4
40 int:IKBKB IKBKB interactions 1.909E-3 3.744E-2
2.718E-1
1.000E0
 2 172
41 int:UCP3 UCP3 interactions 1.976E-3 3.744E-2
2.718E-1
1.000E0
 1 5
42 int:IFITM2 IFITM2 interactions 1.976E-3 3.744E-2
2.718E-1
1.000E0
 1 5
43 int:HIST1H1A HIST1H1A interactions 2.134E-3 3.950E-2
2.867E-1
1.000E0
 2 182
44 int:CEP170 CEP170 interactions 2.299E-3 4.102E-2
2.977E-1
1.000E0
 2 189
45 int:FAM163A FAM163A interactions 2.370E-3 4.102E-2
2.977E-1
1.000E0
 1 6
46 int:ACSS2 ACSS2 interactions 2.370E-3 4.102E-2
2.977E-1
1.000E0
 1 6
47 int:CA1 CA1 interactions 2.765E-3 4.460E-2
3.237E-1
1.000E0
 1 7
48 int:SLC8A2 SLC8A2 interactions 2.765E-3 4.460E-2
3.237E-1
1.000E0
 1 7
49 int:MLXIP MLXIP interactions 2.765E-3 4.460E-2
3.237E-1
1.000E0
 1 7
50 int:MYCBP2 MYCBP2 interactions 2.802E-3 4.460E-2
3.237E-1
1.000E0
 2 209
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19p13.2-p13.11 19p13.2-p13.11 2.020E-4 1.414E-3 3.666E-3 1.414E-3 1 1
2 3q26.3 3q26.3 1.009E-3 3.531E-3 9.157E-3 7.066E-3 1 5
3 5q22.2 5q22.2 1.816E-3 3.531E-3 9.157E-3 1.271E-2 1 9
4 20q13.1 20q13.1 2.018E-3 3.531E-3 9.157E-3 1.413E-2 1 10
5 16p13 16p13 2.623E-3 3.672E-3 9.520E-3 1.836E-2 1 13
6 13q34 13q34 1.206E-2 1.406E-2 3.647E-2
8.439E-2
 1 60
7 12q24.31 12q24.31 1.625E-2 1.625E-2 4.212E-2
1.137E-1
 1 81
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 11 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 3 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1053 14-3-3 phospho-serine/phospho-threonine binding proteins genenames.org 1.154E-3 2.719E-3 4.985E-3 3.462E-3 1 7
2 1169 UPF1 like RNA helicases genenames.org 1.813E-3 2.719E-3 4.985E-3 5.438E-3 1 11
3 667 Nudix hydrolase family genenames.org 3.952E-3 3.952E-3 7.246E-3 1.186E-2 1 24

13: Coexpression [Display Chart] 7 input genes in category / 539 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M9676 Genes up-regulated in CD4 [GeneID=920] T helper cells Th17 treated with TGFB1 and IL6 [GeneID=7040;3569]: 1h versus 20h. MSigDB C7: Immunologic Signatures (v6.0) 2.171E-5 1.170E-2
8.036E-2
 1.170E-2 3 200
2 16143142-Table4 Human Colon diPietro05 54genes GeneSigDB 9.933E-5 2.677E-2
1.839E-1
5.354E-2
 2 51
3 M5922 Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum. MSigDB H: Hallmark Gene Sets (v6.0) 4.886E-4 4.305E-2
2.956E-1
2.634E-1
 2 113
4 M6707 Genes up-regulated in endothelial cells: untreated versus exposed to E. burgdoferi. MSigDB C7: Immunologic Signatures (v6.0) 8.927E-4 4.305E-2
2.956E-1
4.812E-1
 2 153
5 M6564 Genes up-regulated in lesional skin biopsies from mycosis fundoides patients compared to the normal skin samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.192E-3 4.305E-2
2.956E-1
6.423E-1
 2 177
6 M5388 Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 18 h time point that were not up-regulated at the previous time point, 16 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.205E-3 4.305E-2
2.956E-1
6.495E-1
 2 178
7 M5363 Genes up-regulated in comparison of untreated eosinophils versus eosinophils treated with PMA [PubChem=4792] at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 4.305E-2
2.956E-1
8.098E-1
 2 199
8 M4417 Genes down-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated memory CD4 [GeneID=920] CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 4.305E-2
2.956E-1
8.098E-1
 2 199
9 M7064 Genes up-regulated in NK cells: low dose versus high dose of IL2 [GeneID=3558]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.305E-2
2.956E-1
8.179E-1
 2 200
10 M7235 Genes up-regulated in thymus cortical regions: subcapsular versus perimedullary. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.305E-2
2.956E-1
8.179E-1
 2 200
11 M9655 Genes up-regulated in CD4 [GeneID=920] T helper cells (60h): Th0 versus TGFB1 and IL6 [GeneID=7040;3569]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.305E-2
2.956E-1
8.179E-1
 2 200
12 M4878 Genes down-regulated in comparison of erythroblasts versus monocyte macrophages. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.305E-2
2.956E-1
8.179E-1
 2 200
13 M3970 Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.305E-2
2.956E-1
8.179E-1
 2 200
14 M9404 Genes down-regulated in peripheral blood monocytes (PBMC): healthy donors versus patients with HCV infection. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.305E-2
2.956E-1
8.179E-1
 2 200
15 M4885 Genes down-regulated in comparison of naive follicular B cells versus early germinal center (GC) B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.305E-2
2.956E-1
8.179E-1
 2 200
16 M7043 Genes up-regulated in IKZF1 [GeneID=10320] knockout: megakaryo-erythrocyte progenitors versus granulo-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.305E-2
2.956E-1
8.179E-1
 2 200
17 M9785 Genes down-regulated in resting CD8 T cells: wildtype versus MIR155 [GeneID=406947] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.305E-2
2.956E-1
8.179E-1
 2 200
18 M5191 Genes down-regulated in comparison of dendritic cells (DC) exposed to M. tuberculosis versus macrophages exposed to L. major. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.305E-2
2.956E-1
8.179E-1
 2 200
19 M7045 Genes down-regulated in megakaryo-erythrocyte progenitors versus pro-B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.305E-2
2.956E-1
8.179E-1
 2 200
Show 14 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 204 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 5 input genes in category / 73 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 7 input genes in category / 288 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-718:mirSVR lowEffct hsa-miR-718:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.864E-6 8.249E-4 5.149E-3 8.249E-4 3 316
2 hsa-miR-548m:PITA hsa-miR-548m:PITA TOP PITA 8.638E-6 1.050E-3 6.556E-3 2.488E-3 3 457
3 hsa-miR-1236-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.373E-5 1.050E-3 6.556E-3 3.955E-3 2 59
4 hsa-miR-888-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.618E-5 1.050E-3 6.556E-3 4.659E-3 2 64
5 hsa-miR-3118:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.795E-5 1.050E-3 6.556E-3 8.049E-3 2 84
6 hsa-miR-6855-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.069E-5 1.050E-3 6.556E-3 8.837E-3 2 88
7 hsa-miR-4513:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.069E-5 1.050E-3 6.556E-3 8.837E-3 2 88
8 hsa-miR-3136-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.282E-5 1.050E-3 6.556E-3 9.453E-3 2 91
9 hsa-miR-4439:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.282E-5 1.050E-3 6.556E-3 9.453E-3 2 91
10 hsa-miR-134-5p:Functional MTI Functional MTI miRTarbase 4.046E-5 1.165E-3 7.273E-3 1.165E-2 2 101
11 hsa-miR-6857-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.889E-5 1.280E-3 7.989E-3 1.408E-2 2 111
12 hsa-miR-630:PITA hsa-miR-630:PITA TOP PITA 1.571E-4 3.771E-3 2.354E-2 4.525E-2 2 199
13 hsa-miR-29c*:mirSVR lowEffct hsa-miR-29c*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.171E-4 4.809E-3 3.002E-2
6.251E-2
 2 234
14 hsa-miR-365a-3p:TargetScan hsa-miR-365a-3p TargetScan 3.215E-4 6.172E-3 3.853E-2
9.258E-2
 2 285
15 hsa-miR-365b-3p:TargetScan hsa-miR-365b-3p TargetScan 3.215E-4 6.172E-3 3.853E-2
9.258E-2
 2 285
16 CACTGTG,MIR-128A:MSigDB CACTGTG,MIR-128A:MSigDB MSigDB 3.923E-4 6.646E-3 4.148E-2
1.130E-1
 2 315
17 CACTGTG,MIR-128B:MSigDB CACTGTG,MIR-128B:MSigDB MSigDB 3.923E-4 6.646E-3 4.148E-2
1.130E-1
 2 315
18 hsa-miR-219a-5p:TargetScan hsa-miR-219a-5p TargetScan 4.407E-4 7.052E-3 4.402E-2
1.269E-1
 2 334
19 hsa-miR-378a-5p:Functional MTI Functional MTI miRTarbase 5.875E-4 8.905E-3
5.559E-2
1.692E-1
 2 386
20 hsa-miR-148b-3p:Functional MTI Functional MTI miRTarbase 6.399E-4 9.125E-3
5.696E-2
1.843E-1
 2 403
21 hsa-miR-1299:PITA hsa-miR-1299:PITA TOP PITA 6.654E-4 9.125E-3
5.696E-2
1.916E-1
 2 411
22 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 7.859E-4 9.773E-3
6.100E-2
2.263E-1
 2 447
23 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 7.859E-4 9.773E-3
6.100E-2
2.263E-1
 2 447
24 hsa-miR-4431:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.718E-4 9.773E-3
6.100E-2
2.511E-1
 1 9
25 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 9.162E-4 9.773E-3
6.100E-2
2.639E-1
 2 483
26 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 9.162E-4 9.773E-3
6.100E-2
2.639E-1
 2 483
27 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 9.162E-4 9.773E-3
6.100E-2
2.639E-1
 2 483
28 hsa-miR-542-5p:PITA hsa-miR-542-5p:PITA TOP PITA 1.356E-3 1.395E-2
8.705E-2
3.905E-1
 1 14
29 hsa-miR-521:Functional MTI Functional MTI miRTarbase 2.323E-3 2.307E-2
1.440E-1
6.691E-1
 1 24
30 hsa-miR-208b:PITA hsa-miR-208b:PITA TOP PITA 3.000E-3 2.700E-2
1.685E-1
8.640E-1
 1 31
31 hsa-miR-220a:PITA hsa-miR-220a:PITA TOP PITA 3.000E-3 2.700E-2
1.685E-1
8.640E-1
 1 31
32 hsa-miR-208a:PITA hsa-miR-208a:PITA TOP PITA 3.000E-3 2.700E-2
1.685E-1
8.640E-1
 1 31
33 hsa-miR-1909-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.773E-3 3.293E-2
2.055E-1
1.000E0
 1 39
34 hsa-miR-4299:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.546E-3 3.562E-2
2.223E-1
1.000E0
 1 47
35 hsa-miR-3661:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.739E-3 3.562E-2
2.223E-1
1.000E0
 1 49
36 hsa-miR-376a-2-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.739E-3 3.562E-2
2.223E-1
1.000E0
 1 49
37 hsa-miR-631:Functional MTI Functional MTI miRTarbase 4.932E-3 3.562E-2
2.223E-1
1.000E0
 1 51
38 hsa-miR-4765:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.125E-3 3.562E-2
2.223E-1
1.000E0
 1 53
39 hsa-miR-5094:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.317E-3 3.562E-2
2.223E-1
1.000E0
 1 55
40 hsa-miR-3663-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.414E-3 3.562E-2
2.223E-1
1.000E0
 1 56
41 hsa-miR-718:mirSVR highEffct hsa-miR-718:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.510E-3 3.562E-2
2.223E-1
1.000E0
 1 57
42 hsa-miR-2277-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.703E-3 3.562E-2
2.223E-1
1.000E0
 1 59
43 hsa-miR-3164:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 3.562E-2
2.223E-1
1.000E0
 1 60
44 TATCTGG,MIR-488:MSigDB TATCTGG,MIR-488:MSigDB MSigDB 5.800E-3 3.562E-2
2.223E-1
1.000E0
 1 60
45 hsa-miR-4501:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 3.562E-2
2.223E-1
1.000E0
 1 61
46 hsa-miR-6820-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 3.562E-2
2.223E-1
1.000E0
 1 61
47 hsa-miR-619-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.474E-3 3.562E-2
2.223E-1
1.000E0
 1 67
48 hsa-miR-6730-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.571E-3 3.562E-2
2.223E-1
1.000E0
 1 68
49 hsa-miR-6744-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.571E-3 3.562E-2
2.223E-1
1.000E0
 1 68
50 hsa-miR-4679:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.667E-3 3.562E-2
2.223E-1
1.000E0
 1 69
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 1013 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000446186 1i32 Stitch 3.354E-8 3.398E-5 2.548E-4 3.398E-5 4 129
2 CID005288137 AC1NRAX5 Stitch 2.895E-6 1.466E-3 1.100E-2 2.933E-3 2 9
3 6225 DN Butacaine [149-16-6]; Down 200; 13uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.189E-5 7.391E-3
5.542E-2
 2.217E-2 3 198
4 CID004369394 AR E Stitch 3.424E-5 8.670E-3
6.501E-2
 3.468E-2 3 230
5 CID000465394 N-(aminomethyl)succinamic acid Stitch 6.245E-5 1.265E-2
9.487E-2
6.326E-2
 2 40
6 CID000448545 BMS-214662 Stitch 1.060E-4 1.789E-2
1.342E-1
1.074E-1
 2 52
7 CID000125643 UDP-FGlc Stitch 1.509E-4 2.184E-2
1.638E-1
1.529E-1
 2 62
8 CID000003599 miltefosine Stitch 2.391E-4 3.028E-2
2.270E-1
2.422E-1
 2 78
9 CID000004285 N,N-dimethyl-D-erythro-sphingosine Stitch 2.773E-4 3.063E-2
2.297E-1
2.809E-1
 2 84
10 CID006914573 AC1OCA8A Stitch 3.113E-4 3.063E-2
2.297E-1
3.153E-1
 2 89
11 CID000008420 2-naphthalenesulfonate Stitch 3.326E-4 3.063E-2
2.297E-1
3.369E-1
 2 92
12 CID000007454 p-bromophenacyl bromide Stitch 4.087E-4 3.450E-2
2.587E-1
4.140E-1
 2 102
13 CID000446293 1iiq Stitch 5.013E-4 3.906E-2
2.929E-1
5.078E-1
 2 113
14 CID000132211 pyrene-PI Stitch 6.129E-4 4.139E-2
3.103E-1
6.208E-1
 1 2
15 ctd:D012314 RNA Cap Analogs CTD 6.129E-4 4.139E-2
3.103E-1
6.208E-1
 1 2
Show 10 more annotations

18: Disease [Display Chart] 5 input genes in category / 91 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1335299 Pancreatic Adenosquamous Carcinoma DisGeNET BeFree 3.085E-4 9.359E-3 4.767E-2 2.808E-2 1 1
2 C4225356 DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 6 DisGeNET Curated 3.085E-4 9.359E-3 4.767E-2 2.808E-2 1 1
3 C4225347 PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 4 DisGeNET Curated 3.085E-4 9.359E-3 4.767E-2 2.808E-2 1 1
4 C0149782 Squamous cell carcinoma of lung DisGeNET BeFree 1.494E-3 2.353E-2
1.198E-1
1.359E-1
 2 201
5 C4023400 Generalized hypopigmentation of hair DisGeNET Curated 1.542E-3 2.353E-2
1.198E-1
1.403E-1
 1 5
6 C1846142 HOYERAAL-HREIDARSSON SYNDROME DisGeNET Curated 3.390E-3 2.353E-2
1.198E-1
3.085E-1
 1 11
7 C0278076 Behavioral tic DisGeNET Curated 3.390E-3 2.353E-2
1.198E-1
3.085E-1
 1 11
8 C2169806 recurrent muscle twitches (symptom) DisGeNET Curated 3.390E-3 2.353E-2
1.198E-1
3.085E-1
 1 11
9 C1856749 Hypoplastic-absent toenails DisGeNET Curated 3.698E-3 2.353E-2
1.198E-1
3.365E-1
 1 12
10 C4020958 Rough bone trabeculation DisGeNET Curated 3.698E-3 2.353E-2
1.198E-1
3.365E-1
 1 12
11 C0040188 Tic disorder DisGeNET Curated 4.005E-3 2.353E-2
1.198E-1
3.645E-1
 1 13
12 C4025900 Abnormality of female internal genitalia DisGeNET Curated 4.313E-3 2.353E-2
1.198E-1
3.925E-1
 1 14
13 C4280616 Large elongated pulp chamber DisGeNET Curated 4.620E-3 2.353E-2
1.198E-1
4.204E-1
 1 15
14 C0266039 Taurodontism DisGeNET Curated 4.620E-3 2.353E-2
1.198E-1
4.204E-1
 1 15
15 C4024890 Excessive wrinkled skin DisGeNET Curated 4.928E-3 2.353E-2
1.198E-1
4.484E-1
 1 16
16 C0410179 Scleroatonic muscular dystrophy DisGeNET Curated 4.928E-3 2.353E-2
1.198E-1
4.484E-1
 1 16
17 C0014866 Esophageal Stenosis DisGeNET Curated 5.235E-3 2.353E-2
1.198E-1
4.764E-1
 1 17
18 C4024737 Aplasia/Hypoplasia of the skin DisGeNET Curated 5.235E-3 2.353E-2
1.198E-1
4.764E-1
 1 17
19 C0041974 Urethral Stricture DisGeNET Curated 5.542E-3 2.353E-2
1.198E-1
5.043E-1
 1 18
20 C1855204 Cellular immunodeficiency DisGeNET Curated 5.849E-3 2.353E-2
1.198E-1
5.323E-1
 1 19
21 C3495676 Anorectal Malformations DisGeNET Curated 5.849E-3 2.353E-2
1.198E-1
5.323E-1
 1 19
22 C1704317 Leukokeratosis DisGeNET Curated 6.156E-3 2.353E-2
1.198E-1
5.602E-1
 1 20
23 C4025838 Abnormality of the pharynx DisGeNET Curated 6.156E-3 2.353E-2
1.198E-1
5.602E-1
 1 20
24 C0427515 Neutrophil abnormality DisGeNET Curated 6.464E-3 2.353E-2
1.198E-1
5.882E-1
 1 21
25 C1855710 Bone marrow hypocellularity DisGeNET Curated 6.464E-3 2.353E-2
1.198E-1
5.882E-1
 1 21
26 C4024878 Generalized hyperpigmentation DisGeNET Curated 6.770E-3 2.370E-2
1.207E-1
6.161E-1
 1 22
27 C1260926 Abnormal pigmentation DisGeNET Curated 7.691E-3 2.500E-2
1.273E-1
6.999E-1
 1 25
28 C0263498 Premature canities DisGeNET Curated 7.691E-3 2.500E-2
1.273E-1
6.999E-1
 1 25
29 C0259785 Malignant Meningioma DisGeNET BeFree 8.304E-3 2.606E-2
1.327E-1
7.557E-1
 1 27
30 C1846821 Coagulation abnormalities DisGeNET Curated 8.611E-3 2.612E-2
1.330E-1
7.836E-1
 1 28
31 C0040588 Tracheoesophageal Fistula DisGeNET Curated 1.137E-2 3.287E-2
1.674E-1
1.000E0
 1 37
32 C0265965 Dyskeratosis Congenita DisGeNET Curated 1.198E-2 3.287E-2
1.674E-1
1.000E0
 1 39
33 C0019087 Hemorrhagic Disorders DisGeNET Curated 1.198E-2 3.287E-2
1.674E-1
1.000E0
 1 39
34 C4022018 Telangiectasia of the skin DisGeNET Curated 1.228E-2 3.287E-2
1.674E-1
1.000E0
 1 40
35 C1857042 Sparse scalp hair DisGeNET Curated 1.289E-2 3.336E-2
1.699E-1
1.000E0
 1 42
36 C1842774 Hyperpigmented macules DisGeNET Curated 1.320E-2 3.336E-2
1.699E-1
1.000E0
 1 43
37 C4021782 Abnormality of the fingernails DisGeNET Curated 1.594E-2 3.549E-2
1.808E-1
1.000E0
 1 52
38 C3805574 Increased fracture rate DisGeNET Curated 1.655E-2 3.549E-2
1.808E-1
1.000E0
 1 54
39 C3806283 Frequent fractures DisGeNET Curated 1.655E-2 3.549E-2
1.808E-1
1.000E0
 1 54
40 C1833752 Varying degree of multiple fractures DisGeNET Curated 1.655E-2 3.549E-2
1.808E-1
1.000E0
 1 54
41 C0221260 Dystrophia unguium DisGeNET Curated 1.686E-2 3.549E-2
1.808E-1
1.000E0
 1 55
42 C2220104 Blister of skin DisGeNET Curated 1.716E-2 3.549E-2
1.808E-1
1.000E0
 1 56
43 C2132198 Abnormal blistering of the skin DisGeNET Curated 1.716E-2 3.549E-2
1.808E-1
1.000E0
 1 56
44 C0241054 Skin bulla DisGeNET Curated 1.716E-2 3.549E-2
1.808E-1
1.000E0
 1 56
45 C1836735 hypopigmented skin patch DisGeNET Curated 1.838E-2 3.617E-2
1.842E-1
1.000E0
 1 60
46 C1837770 Sparse hair DisGeNET Curated 1.868E-2 3.617E-2
1.842E-1
1.000E0
 1 61
47 C1860844 Thin, sparse hair DisGeNET Curated 1.868E-2 3.617E-2
1.842E-1
1.000E0
 1 61
48 C0001956 alcohol use disorder DisGeNET Curated 1.929E-2 3.657E-2
1.863E-1
1.000E0
 1 63
49 C0023532 Leukoplakia, Oral DisGeNET Curated 2.050E-2 3.767E-2
1.919E-1
1.000E0
 1 67
50 C0206655 Alveolar rhabdomyosarcoma DisGeNET Curated 2.081E-2 3.767E-2
1.919E-1
1.000E0
 1 68
Show 45 more annotations