Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc203_12, positive side

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1: GO: Molecular Function [Display Chart] 12 input genes in category / 73 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005254 chloride channel activity 5.012E-12 2.855E-10 1.392E-9 3.659E-10 6 81
2 GO:0015108 chloride transmembrane transporter activity 1.098E-11 2.855E-10 1.392E-9 8.015E-10 6 92
3 GO:0005253 anion channel activity 1.173E-11 2.855E-10 1.392E-9 8.565E-10 6 93
4 GO:0005247 voltage-gated chloride channel activity 4.838E-11 8.829E-10 4.304E-9 3.531E-9 4 12
5 GO:0015103 inorganic anion transmembrane transporter activity 9.970E-11 1.456E-9 7.095E-9 7.278E-9 6 132
6 GO:0008308 voltage-gated anion channel activity 2.984E-10 3.631E-9 1.770E-8 2.179E-8 4 18
7 GO:0005244 voltage-gated ion channel activity 1.159E-9 1.058E-8 5.156E-8 8.461E-8 6 198
8 GO:0022832 voltage-gated channel activity 1.159E-9 1.058E-8 5.156E-8 8.461E-8 6 198
9 GO:0008509 anion transmembrane transporter activity 1.318E-8 1.069E-7 5.210E-7 9.619E-7 6 297
10 GO:0022836 gated channel activity 2.514E-8 1.835E-7 8.947E-7 1.835E-6 6 331
11 GO:0005216 ion channel activity 1.093E-7 7.255E-7 3.536E-6 7.980E-6 6 424
12 GO:0022838 substrate-specific channel activity 1.325E-7 8.059E-7 3.928E-6 9.671E-6 6 438
13 GO:0015267 channel activity 2.009E-7 1.061E-6 5.171E-6 1.467E-5 6 470
14 GO:0022803 passive transmembrane transporter activity 2.034E-7 1.061E-6 5.171E-6 1.485E-5 6 471
15 GO:0004364 glutathione transferase activity 2.102E-4 1.023E-3 4.988E-3 1.535E-2 2 34
16 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 7.244E-4 3.305E-3 1.611E-2
5.288E-2
 2 63
17 GO:0015297 antiporter activity 1.253E-3 4.693E-3 2.288E-2
9.148E-2
 2 83
18 GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway 1.286E-3 4.693E-3 2.288E-2
9.386E-2
 1 2
19 GO:0072320 volume-sensitive chloride channel activity 1.286E-3 4.693E-3 2.288E-2
9.386E-2
 1 2
20 GO:0031751 D4 dopamine receptor binding 1.286E-3 4.693E-3 2.288E-2
9.386E-2
 1 2
21 GO:0022804 active transmembrane transporter activity 1.409E-3 4.900E-3 2.388E-2
1.029E-1
 3 363
22 GO:0031750 D3 dopamine receptor binding 2.570E-3 8.528E-3 4.157E-2
1.876E-1
 1 4
23 GO:0005225 volume-sensitive anion channel activity 3.853E-3 1.125E-2
5.484E-2
2.812E-1
 1 6
24 GO:0004064 arylesterase activity 3.853E-3 1.125E-2
5.484E-2
2.812E-1
 1 6
25 GO:0031749 D2 dopamine receptor binding 3.853E-3 1.125E-2
5.484E-2
2.812E-1
 1 6
26 GO:0008603 cAMP-dependent protein kinase regulator activity 5.134E-3 1.388E-2
6.766E-2
3.748E-1
 1 8
27 GO:0071936 coreceptor activity involved in Wnt signaling pathway 5.134E-3 1.388E-2
6.766E-2
3.748E-1
 1 8
28 GO:0004862 cAMP-dependent protein kinase inhibitor activity 5.774E-3 1.505E-2
7.338E-2
4.215E-1
 1 9
29 GO:0019534 toxin transmembrane transporter activity 6.413E-3 1.614E-2
7.870E-2
4.682E-1
 1 10
30 GO:0008607 phosphorylase kinase regulator activity 7.053E-3 1.716E-2
8.365E-2
5.149E-1
 1 11
31 GO:0016208 AMP binding 8.968E-3 1.984E-2
9.671E-2
6.547E-1
 1 14
32 GO:0004679 AMP-activated protein kinase activity 8.968E-3 1.984E-2
9.671E-2
6.547E-1
 1 14
33 GO:0004089 carbonate dehydratase activity 8.968E-3 1.984E-2
9.671E-2
6.547E-1
 1 14
34 GO:0015291 secondary active transmembrane transporter activity 9.669E-3 2.076E-2
1.012E-1
7.058E-1
 2 236
35 GO:0050780 dopamine receptor binding 1.406E-2 2.851E-2
1.390E-1
1.000E0
 1 22
36 GO:0042813 Wnt-activated receptor activity 1.406E-2 2.851E-2
1.390E-1
1.000E0
 1 22
37 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1.469E-2 2.899E-2
1.413E-1
1.000E0
 1 23
38 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1.596E-2 3.067E-2
1.495E-1
1.000E0
 1 25
39 GO:0036442 proton-exporting ATPase activity 1.850E-2 3.462E-2
1.688E-1
1.000E0
 1 29
40 GO:0030291 protein serine/threonine kinase inhibitor activity 1.913E-2 3.491E-2
1.702E-1
1.000E0
 1 30
41 GO:0017147 Wnt-protein binding 2.039E-2 3.631E-2
1.770E-1
1.000E0
 1 32
42 GO:0043531 ADP binding 2.606E-2 4.529E-2
2.208E-1
1.000E0
 1 41
43 GO:0015026 coreceptor activity 2.668E-2 4.530E-2
2.208E-1
1.000E0
 1 42
Show 38 more annotations

2: GO: Biological Process [Display Chart] 12 input genes in category / 487 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006821 chloride transport 9.289E-14 4.524E-11 3.061E-10 4.524E-11 7 102
2 GO:0015698 inorganic anion transport 1.764E-12 4.294E-10 2.906E-9 8.588E-10 7 154
3 GO:1902476 chloride transmembrane transport 1.039E-11 1.687E-9 1.141E-8 5.061E-9 6 91
4 GO:0098661 inorganic anion transmembrane transport 3.708E-11 4.515E-9 3.055E-8 1.806E-8 6 112
5 GO:0098656 anion transmembrane transport 8.354E-11 8.137E-9 5.506E-8 4.068E-8 7 266
6 GO:1903959 regulation of anion transmembrane transport 4.535E-9 3.220E-7 2.179E-6 2.209E-6 4 34
7 GO:0034762 regulation of transmembrane transport 4.629E-9 3.220E-7 2.179E-6 2.254E-6 7 473
8 GO:0044070 regulation of anion transport 3.989E-8 2.428E-6 1.643E-5 1.943E-5 5 166
9 GO:0034765 regulation of ion transmembrane transport 1.679E-7 9.085E-6 6.147E-5 8.177E-5 6 455
10 GO:0051452 intracellular pH reduction 3.478E-6 1.694E-4 1.146E-3 1.694E-3 3 48
11 GO:0045851 pH reduction 4.183E-6 1.852E-4 1.253E-3 2.037E-3 3 51
12 GO:0051453 regulation of intracellular pH 1.572E-5 6.351E-4 4.297E-3 7.658E-3 3 79
13 GO:0030641 regulation of cellular pH 1.695E-5 6.351E-4 4.297E-3 8.256E-3 3 81
14 GO:0006885 regulation of pH 3.386E-5 1.178E-3 7.969E-3 1.649E-2 3 102
15 GO:0030004 cellular monovalent inorganic cation homeostasis 3.799E-5 1.233E-3 8.345E-3 1.850E-2 3 106
16 GO:0055067 monovalent inorganic cation homeostasis 1.246E-4 3.793E-3 2.567E-2
6.069E-2
 3 158
17 GO:0009268 response to pH 3.878E-4 1.083E-2
7.325E-2
1.889E-1
 2 46
18 GO:0051932 synaptic transmission, GABAergic 4.223E-4 1.083E-2
7.325E-2
2.057E-1
 2 48
19 GO:0006754 ATP biosynthetic process 4.223E-4 1.083E-2
7.325E-2
2.057E-1
 2 48
20 GO:0046850 regulation of bone remodeling 5.546E-4 1.350E-2
9.138E-2
2.701E-1
 2 55
21 GO:0009206 purine ribonucleoside triphosphate biosynthetic process 6.381E-4 1.461E-2
9.884E-2
3.108E-1
 2 59
22 GO:0009145 purine nucleoside triphosphate biosynthetic process 6.599E-4 1.461E-2
9.884E-2
3.214E-1
 2 60
23 GO:0009201 ribonucleoside triphosphate biosynthetic process 7.740E-4 1.639E-2
1.109E-1
3.770E-1
 2 65
24 GO:0006749 glutathione metabolic process 8.468E-4 1.651E-2
1.117E-1
4.124E-1
 2 68
25 GO:0009168 purine ribonucleoside monophosphate biosynthetic process 1.002E-3 1.651E-2
1.117E-1
4.879E-1
 2 74
26 GO:0009127 purine nucleoside monophosphate biosynthetic process 1.002E-3 1.651E-2
1.117E-1
4.879E-1
 2 74
27 GO:0009142 nucleoside triphosphate biosynthetic process 1.084E-3 1.651E-2
1.117E-1
5.280E-1
 2 77
28 GO:0034103 regulation of tissue remodeling 1.112E-3 1.651E-2
1.117E-1
5.417E-1
 2 78
29 GO:0007588 excretion 1.170E-3 1.651E-2
1.117E-1
5.696E-1
 2 80
30 GO:0060764 cell-cell signaling involved in mammary gland development 1.288E-3 1.651E-2
1.117E-1
6.274E-1
 1 2
31 GO:2001148 regulation of dipeptide transmembrane transport 1.288E-3 1.651E-2
1.117E-1
6.274E-1
 1 2
32 GO:2000880 positive regulation of dipeptide transport 1.288E-3 1.651E-2
1.117E-1
6.274E-1
 1 2
33 GO:0097401 synaptic vesicle lumen acidification 1.288E-3 1.651E-2
1.117E-1
6.274E-1
 1 2
34 GO:2000878 positive regulation of oligopeptide transport 1.288E-3 1.651E-2
1.117E-1
6.274E-1
 1 2
35 GO:0090089 regulation of dipeptide transport 1.288E-3 1.651E-2
1.117E-1
6.274E-1
 1 2
36 GO:0090088 regulation of oligopeptide transport 1.288E-3 1.651E-2
1.117E-1
6.274E-1
 1 2
37 GO:2001150 positive regulation of dipeptide transmembrane transport 1.288E-3 1.651E-2
1.117E-1
6.274E-1
 1 2
38 GO:0035442 dipeptide transmembrane transport 1.288E-3 1.651E-2
1.117E-1
6.274E-1
 1 2
39 GO:0009156 ribonucleoside monophosphate biosynthetic process 1.350E-3 1.686E-2
1.141E-1
6.574E-1
 2 86
40 GO:0009124 nucleoside monophosphate biosynthetic process 1.610E-3 1.912E-2
1.294E-1
7.840E-1
 2 94
41 GO:0046849 bone remodeling 1.610E-3 1.912E-2
1.294E-1
7.840E-1
 2 94
42 GO:0030316 osteoclast differentiation 1.855E-3 2.002E-2
1.355E-1
9.035E-1
 2 101
43 GO:0042451 purine nucleoside biosynthetic process 1.892E-3 2.002E-2
1.355E-1
9.212E-1
 2 102
44 GO:0046129 purine ribonucleoside biosynthetic process 1.892E-3 2.002E-2
1.355E-1
9.212E-1
 2 102
45 GO:0072053 renal inner medulla development 1.932E-3 2.002E-2
1.355E-1
9.409E-1
 1 3
46 GO:0042938 dipeptide transport 1.932E-3 2.002E-2
1.355E-1
9.409E-1
 1 3
47 GO:0048388 endosomal lumen acidification 1.932E-3 2.002E-2
1.355E-1
9.409E-1
 1 3
48 GO:0032849 positive regulation of cellular pH reduction 2.575E-3 2.508E-2
1.697E-1
1.000E0
 1 4
49 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering 2.575E-3 2.508E-2
1.697E-1
1.000E0
 1 4
50 GO:1904393 regulation of skeletal muscle acetylcholine-gated channel clustering 2.575E-3 2.508E-2
1.697E-1
1.000E0
 1 4
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 12 input genes in category / 60 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0034707 chloride channel complex 2.042E-8 1.225E-6 5.732E-6 1.225E-6 4 50
2 GO:0045335 phagocytic vesicle 2.030E-5 4.783E-4 2.239E-3 1.218E-3 3 88
3 GO:0034702 ion channel complex 2.392E-5 4.783E-4 2.239E-3 1.435E-3 4 291
4 GO:1902495 transmembrane transporter complex 3.776E-5 4.864E-4 2.277E-3 2.265E-3 4 327
5 GO:1990351 transporter complex 4.054E-5 4.864E-4 2.277E-3 2.432E-3 4 333
6 GO:0045177 apical part of cell 1.075E-4 1.075E-3 5.033E-3 6.453E-3 4 428
7 GO:0030139 endocytic vesicle 5.327E-4 4.040E-3 1.891E-2 3.196E-2 3 265
8 GO:0098852 lytic vacuole membrane 6.061E-4 4.040E-3 1.891E-2 3.636E-2 3 277
9 GO:0005765 lysosomal membrane 6.061E-4 4.040E-3 1.891E-2 3.636E-2 3 277
10 GO:0016324 apical plasma membrane 1.052E-3 6.313E-3 2.954E-2
6.313E-2
 3 335
11 GO:0034684 integrin alphav-beta5 complex 1.259E-3 6.866E-3 3.213E-2
7.553E-2
 1 2
12 GO:1990851 Wnt-Frizzled-LRP5/6 complex 3.144E-3 1.572E-2
7.357E-2
1.886E-1
 1 5
13 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain 3.772E-3 1.741E-2
8.147E-2
2.263E-1
 1 6
14 GO:0031588 nucleotide-activated protein kinase complex 6.279E-3 2.512E-2
1.175E-1
3.768E-1
 1 10
15 GO:0033179 proton-transporting V-type ATPase, V0 domain 6.279E-3 2.512E-2
1.175E-1
3.768E-1
 1 10
16 GO:0042581 specific granule 8.781E-3 2.927E-2
1.370E-1
5.268E-1
 1 14
17 GO:1990909 Wnt signalosome 8.781E-3 2.927E-2
1.370E-1
5.268E-1
 1 14
18 GO:0016471 vacuolar proton-transporting V-type ATPase complex 8.781E-3 2.927E-2
1.370E-1
5.268E-1
 1 14
19 GO:0016323 basolateral plasma membrane 9.897E-3 3.126E-2
1.463E-1
5.938E-1
 2 244
20 GO:0060077 inhibitory synapse 1.252E-2 3.757E-2
1.758E-1
7.513E-1
 1 20
21 GO:0033176 proton-transporting V-type ATPase complex 1.439E-2 3.924E-2
1.836E-1
8.633E-1
 1 23
22 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain 1.439E-2 3.924E-2
1.836E-1
8.633E-1
 1 23
23 GO:0043235 receptor complex 1.850E-2 4.495E-2
2.104E-1
1.000E0
 2 339
24 GO:0008305 integrin complex 1.873E-2 4.495E-2
2.104E-1
1.000E0
 1 30
25 GO:0098636 protein complex involved in cell adhesion 1.873E-2 4.495E-2
2.104E-1
1.000E0
 1 30
Show 20 more annotations

4: Human Phenotype [Display Chart] 8 input genes in category / 543 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0011002 Osteopetrosis 4.483E-11 2.434E-8 1.674E-7 2.434E-8 5 20
2 HP:0001293 Cranial nerve compression 4.273E-8 1.160E-5 7.977E-5 2.320E-5 4 25
3 HP:0007807 Optic nerve compression 3.626E-6 6.563E-4 4.512E-3 1.969E-3 3 20
4 HP:0004909 Hypokalemic hypochloremic metabolic alkalosis 7.578E-6 1.029E-3 7.072E-3 4.115E-3 2 3
5 HP:0005977 Hypochloremic metabolic alkalosis 2.522E-5 2.052E-3 1.411E-2 1.369E-2 2 5
6 HP:0007209 Facial paralysis 2.522E-5 2.052E-3 1.411E-2 1.369E-2 2 5
7 HP:0002914 Hyperchloriduria 3.779E-5 2.052E-3 1.411E-2 2.052E-2 2 6
8 HP:0012600 Abnormal urine chloride concentration 3.779E-5 2.052E-3 1.411E-2 2.052E-2 2 6
9 HP:0003081 Increased urinary potassium 3.779E-5 2.052E-3 1.411E-2 2.052E-2 2 6
10 HP:0005789 Generalized osteosclerosis 3.779E-5 2.052E-3 1.411E-2 2.052E-2 2 6
11 HP:0002757 Recurrent fractures 6.615E-5 3.265E-3 2.245E-2 3.592E-2 4 152
12 HP:0012213 Decreased glomerular filtration rate 9.047E-5 3.509E-3 2.413E-2 4.913E-2 2 9
13 HP:0001563 Fetal polyuria 9.047E-5 3.509E-3 2.413E-2 4.913E-2 2 9
14 HP:0012212 Abnormal glomerular filtration rate 9.047E-5 3.509E-3 2.413E-2 4.913E-2 2 9
15 HP:0002653 Bone pain 9.800E-5 3.548E-3 2.439E-2
5.321E-2
 4 168
16 HP:0001960 Hypokalemic metabolic alkalosis 1.130E-4 3.609E-3 2.481E-2
6.135E-2
 2 10
17 HP:0012605 Hypernatriuria 1.130E-4 3.609E-3 2.481E-2
6.135E-2
 2 10
18 HP:0011001 Increased bone mineral density 1.273E-4 3.841E-3 2.641E-2
6.913E-2
 5 366
19 HP:0012603 Abnormal urine sodium concentration 1.380E-4 3.943E-3 2.711E-2
7.493E-2
 2 11
20 HP:0012598 Abnormal urine potassium concentration 1.954E-4 5.051E-3 3.473E-2
1.061E-1
 2 13
21 HP:0001949 Hypokalemic alkalosis 1.954E-4 5.051E-3 3.473E-2
1.061E-1
 2 13
22 HP:0002659 Increased susceptibility to fractures 2.803E-4 6.917E-3 4.756E-2
1.522E-1
 4 220
23 HP:0000940 Abnormal diaphysis morphology 3.329E-4 7.373E-3
5.069E-2
1.807E-1
 4 230
24 HP:0003148 Elevated serum acid phosphatase 3.395E-4 7.373E-3
5.069E-2
1.843E-1
 2 17
25 HP:0010543 Opsoclonus 3.395E-4 7.373E-3
5.069E-2
1.843E-1
 2 17
26 HP:0003470 Paralysis 3.558E-4 7.430E-3
5.108E-2
1.932E-1
 4 234
27 HP:0006323 Premature loss of primary teeth 3.816E-4 7.674E-3
5.276E-2
2.072E-1
 2 18
28 HP:0004356 Abnormality of lysosomal metabolism 5.224E-4 1.013E-2
6.965E-2
2.837E-1
 2 21
29 HP:0001281 Tetany 6.283E-4 1.176E-2
8.088E-2
3.412E-1
 2 23
30 HP:0003113 Hypochloremia 6.848E-4 1.240E-2
8.522E-2
3.719E-1
 2 24
31 HP:0001363 Craniosynostosis 7.653E-4 1.340E-2
9.216E-2
4.156E-1
 3 117
32 HP:0011422 Abnormality of chloride homeostasis 1.147E-3 1.810E-2
1.244E-1
6.228E-1
 2 31
33 HP:0010929 Abnormality of cation homeostasis 1.450E-3 1.810E-2
1.244E-1
7.873E-1
 4 338
34 HP:0001291 Abnormal cranial nerve morphology 1.450E-3 1.810E-2
1.244E-1
7.873E-1
 4 338
35 HP:0000127 Renal salt wasting 1.547E-3 1.810E-2
1.244E-1
8.402E-1
 2 36
36 HP:0008037 Absent anterior chamber of the eye 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
37 HP:0030326 Abnormal macrophage count 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
38 HP:0008114 Metatarsal diaphyseal endosteal sclerosis 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
39 HP:0004618 Sandwich appearance of vertebral bodies 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
40 HP:0100861 Sclerotic vertebral body 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
41 HP:0030327 Abnormal osteoclast count 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
42 HP:0004563 Increased spinal bone density 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
43 HP:0006684 Ventricular preexcitation with multiple accessory pathways 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
44 HP:0030328 Decreased osteoclast count 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
45 HP:0011642 Abnormal coronary sinus morphology 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
46 HP:0011644 Coronary sinus diverticulum 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
47 HP:0011687 AV nodal tachycardia 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
48 HP:0006174 Metacarpal diaphyseal endosteal sclerosis 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
49 HP:0011851 Hemopericardium 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
50 HP:0005579 Impaired reabsorption of chloride 1.700E-3 1.810E-2
1.244E-1
9.229E-1
 1 1
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 11 input genes in category / 643 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004945 abnormal bone resorption 1.213E-6 5.020E-4 3.536E-3 7.803E-4 4 83
2 MP:0000121 failure of tooth eruption 1.561E-6 5.020E-4 3.536E-3 1.004E-3 3 23
3 MP:0005605 increased bone mass 2.464E-6 5.282E-4 3.720E-3 1.585E-3 4 99
4 MP:0000119 abnormal tooth eruption 5.730E-6 9.211E-4 6.488E-3 3.684E-3 3 35
5 MP:0000064 failure of bone resorption 1.024E-5 1.317E-3 9.278E-3 6.586E-3 2 5
6 MP:0000067 osteopetrosis 1.321E-5 1.415E-3 9.969E-3 8.491E-3 3 46
7 MP:0003797 abnormal compact bone morphology 2.827E-5 2.597E-3 1.829E-2 1.818E-2 4 183
8 MP:0002998 abnormal bone remodeling 3.628E-5 2.628E-3 1.851E-2 2.333E-2 4 195
9 MP:0013614 abnormal areal bone mineral density 3.679E-5 2.628E-3 1.851E-2 2.365E-2 2 9
10 MP:0008733 abnormal hair shaft melanin granule distribution 4.596E-5 2.955E-3 2.081E-2 2.955E-2 2 10
11 MP:0004119 hypokalemia 9.272E-5 5.420E-3 3.818E-2
5.962E-2
 2 14
12 MP:0003027 abnormal blood pH regulation 1.221E-4 6.544E-3 4.609E-2
7.852E-2
 2 16
13 MP:0000130 abnormal trabecular bone morphology 1.940E-4 8.564E-3
6.032E-2
1.247E-1
 4 300
14 MP:0000116 abnormal tooth development 2.011E-4 8.564E-3
6.032E-2
1.293E-1
 3 114
15 MP:0008274 failure of bone ossification 2.131E-4 8.564E-3
6.032E-2
1.370E-1
 2 21
16 MP:0030542 abnormal dentin development 2.131E-4 8.564E-3
6.032E-2
1.370E-1
 2 21
17 MP:0001326 retinal degeneration 2.283E-4 8.635E-3
6.083E-2
1.468E-1
 3 119
18 MP:0010872 increased trabecular bone mass 2.796E-4 9.582E-3
6.750E-2
1.798E-1
 2 24
19 MP:0000134 abnormal compact bone thickness 2.831E-4 9.582E-3
6.750E-2
1.821E-1
 3 128
20 MP:0008731 abnormal hair shaft melanin granule morphology 3.037E-4 9.764E-3
6.878E-2
1.953E-1
 2 25
21 MP:0004983 abnormal osteoclast cell number 3.241E-4 9.922E-3
6.989E-2
2.084E-1
 3 134
22 MP:0002818 abnormal dentin morphology 3.549E-4 1.037E-2
7.307E-2
2.282E-1
 2 27
23 MP:0000811 hippocampal neuron degeneration 4.101E-4 1.140E-2
8.029E-2
2.637E-1
 2 29
24 MP:0000062 increased bone mineral density 4.254E-4 1.140E-2
8.029E-2
2.736E-1
 3 147
25 MP:0010123 increased bone mineral content 5.554E-4 1.428E-2
1.006E-1
3.571E-1
 3 161
26 MP:0004991 decreased bone strength 5.989E-4 1.481E-2
1.043E-1
3.851E-1
 2 35
27 MP:0004993 decreased bone resorption 7.064E-4 1.682E-2
1.185E-1
4.542E-1
 2 38
28 MP:0001004 abnormal retinal photoreceptor morphology 8.864E-4 1.874E-2
1.320E-1
5.699E-1
 3 189
29 MP:0004982 abnormal osteoclast morphology 8.864E-4 1.874E-2
1.320E-1
5.699E-1
 3 189
30 MP:0008271 abnormal bone ossification 8.874E-4 1.874E-2
1.320E-1
5.706E-1
 4 447
31 MP:0000065 abnormal bone marrow cavity morphology 9.472E-4 1.874E-2
1.320E-1
6.091E-1
 2 44
32 MP:0009969 abnormal cerebral cortex pyramidal cell morphology 9.472E-4 1.874E-2
1.320E-1
6.091E-1
 2 44
33 MP:0003728 abnormal retinal photoreceptor layer morphology 9.851E-4 1.874E-2
1.320E-1
6.334E-1
 3 196
34 MP:0011084 lethality at weaning, incomplete penetrance 9.907E-4 1.874E-2
1.320E-1
6.370E-1
 2 45
35 MP:0010013 cerebral cortex pyramidal cell degeneration 1.062E-3 1.917E-2
1.350E-1
6.831E-1
 1 1
36 MP:0003562 abnormal pancreatic beta cell physiology 1.154E-3 1.917E-2
1.350E-1
7.420E-1
 3 207
37 MP:0009347 increased trabecular bone thickness 1.174E-3 1.917E-2
1.350E-1
7.550E-1
 2 49
38 MP:0010147 abnormal endocrine pancreas physiology 1.203E-3 1.917E-2
1.350E-1
7.735E-1
 3 210
39 MP:0004043 abnormal pH regulation 1.222E-3 1.917E-2
1.350E-1
7.860E-1
 2 50
40 MP:0010871 abnormal trabecular bone mass 1.222E-3 1.917E-2
1.350E-1
7.860E-1
 2 50
41 MP:0005628 decreased circulating potassium level 1.222E-3 1.917E-2
1.350E-1
7.860E-1
 2 50
42 MP:0010119 abnormal bone mineral density 1.291E-3 1.931E-2
1.360E-1
8.302E-1
 4 494
43 MP:0030608 decreased tooth number 1.322E-3 1.931E-2
1.360E-1
8.498E-1
 2 52
44 MP:0010868 increased bone trabecula number 1.322E-3 1.931E-2
1.360E-1
8.498E-1
 2 52
45 MP:0002183 gliosis 1.412E-3 2.018E-2
1.422E-1
9.082E-1
 3 222
46 MP:0003730 abnormal photoreceptor inner segment morphology 1.642E-3 2.295E-2
1.617E-1
1.000E0
 2 58
47 MP:0003930 abnormal tooth hard tissue morphology 1.756E-3 2.396E-2
1.687E-1
1.000E0
 2 60
48 MP:0030611 abnormal tooth number 2.057E-3 2.396E-2
1.687E-1
1.000E0
 2 65
49 MP:0005075 abnormal melanosome morphology 2.057E-3 2.396E-2
1.687E-1
1.000E0
 2 65
50 MP:0002100 abnormal tooth morphology 2.080E-3 2.396E-2
1.687E-1
1.000E0
 3 254
Show 45 more annotations

6: Domain [Display Chart] 12 input genes in category / 83 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00116 CBS SMART 1.793E-13 1.319E-11 6.599E-11 1.488E-11 5 16
2 PF00571 CBS Pfam 6.357E-13 1.319E-11 6.599E-11 5.277E-11 5 20
3 IPR000644 CBS dom InterPro 6.357E-13 1.319E-11 6.599E-11 5.277E-11 5 20
4 PS51371 CBS PROSITE 6.357E-13 1.319E-11 6.599E-11 5.277E-11 5 20
5 IPR001807 Cl-channel volt-gated InterPro 1.213E-11 1.259E-10 6.297E-10 1.007E-9 4 9
6 1.10.3080.10 - Gene3D 1.213E-11 1.259E-10 6.297E-10 1.007E-9 4 9
7 IPR014743 Cl-channel core InterPro 1.213E-11 1.259E-10 6.297E-10 1.007E-9 4 9
8 PF00654 Voltage CLC Pfam 1.213E-11 1.259E-10 6.297E-10 1.007E-9 4 9
9 IPR002250 Cl channel-K InterPro 3.761E-7 3.468E-6 1.735E-5 3.122E-5 2 2
10 IPR002946 CLIC InterPro 5.633E-6 4.676E-5 2.339E-4 4.676E-4 2 6
11 PS50405 GST CTER PROSITE 2.086E-4 1.574E-3 7.873E-3 1.731E-2 2 34
12 1.20.1050.10 - Gene3D 2.750E-4 1.756E-3 8.784E-3 2.283E-2 2 39
13 IPR010987 Glutathione-S-Trfase C-like InterPro 2.750E-4 1.756E-3 8.784E-3 2.283E-2 2 39
14 IPR002245 Cl channel-3 InterPro 6.405E-4 2.658E-3 1.330E-2
5.316E-2
 1 1
15 IPR019172 Osteopetrosis-assoc TM 1 InterPro 6.405E-4 2.658E-3 1.330E-2
5.316E-2
 1 1
16 IPR027067 Integrin beta-5 InterPro 6.405E-4 2.658E-3 1.330E-2
5.316E-2
 1 1
17 IPR030263 CLIC-6 InterPro 6.405E-4 2.658E-3 1.330E-2
5.316E-2
 1 1
18 IPR002249 Cl channel-7 InterPro 6.405E-4 2.658E-3 1.330E-2
5.316E-2
 1 1
19 IPR030259 CLIC-1 InterPro 6.405E-4 2.658E-3 1.330E-2
5.316E-2
 1 1
20 PF09777 OSTMP1 Pfam 6.405E-4 2.658E-3 1.330E-2
5.316E-2
 1 1
21 IPR018443 CA2 InterPro 1.281E-3 4.621E-3 2.312E-2
1.063E-1
 1 2
22 IPR017049 LRP5/6 InterPro 1.281E-3 4.621E-3 2.312E-2
1.063E-1
 1 2
23 PF13409 GST N 2 Pfam 1.281E-3 4.621E-3 2.312E-2
1.063E-1
 1 2
24 IPR002490 V-ATPase 116kDa su InterPro 2.560E-3 7.869E-3 3.936E-2
2.125E-1
 1 4
25 PF01496 V ATPase I Pfam 2.560E-3 7.869E-3 3.936E-2
2.125E-1
 1 4
26 1.20.5.630 - Gene3D 2.560E-3 7.869E-3 3.936E-2
2.125E-1
 1 4
27 IPR026028 V-type ATPase 116kDa su euka InterPro 2.560E-3 7.869E-3 3.936E-2
2.125E-1
 1 4
28 3.40.30.10 - Gene3D 2.660E-3 7.885E-3 3.944E-2
2.208E-1
 2 122
29 PF00008 EGF Pfam 2.834E-3 8.111E-3 4.057E-2
2.352E-1
 2 126
30 IPR012336 Thioredoxin-like fold InterPro 3.105E-3 8.590E-3 4.297E-2
2.577E-1
 2 132
31 PF08725 Integrin b cyt Pfam 3.837E-3 9.652E-3 4.828E-2
3.185E-1
 1 6
32 IPR014836 Integrin bsu cyt dom InterPro 3.837E-3 9.652E-3 4.828E-2
3.185E-1
 1 6
33 SM01241 Integrin b cyt SMART 3.837E-3 9.652E-3 4.828E-2
3.185E-1
 1 6
34 PF07965 Integrin B tail Pfam 4.476E-3 1.032E-2
5.162E-2
3.715E-1
 1 7
35 IPR012896 Integrin bsu tail InterPro 4.476E-3 1.032E-2
5.162E-2
3.715E-1
 1 7
36 SM01242 Integrin B tail SMART 4.476E-3 1.032E-2
5.162E-2
3.715E-1
 1 7
37 IPR002369 Integrin bsu VWA InterPro 5.114E-3 1.088E-2
5.444E-2
4.244E-1
 1 8
38 SM00187 INB SMART 5.114E-3 1.088E-2
5.444E-2
4.244E-1
 1 8
39 PF00362 Integrin beta Pfam 5.114E-3 1.088E-2
5.444E-2
4.244E-1
 1 8
40 PS00243 INTEGRIN BETA PROSITE 5.751E-3 1.110E-2
5.553E-2
4.773E-1
 1 9
41 PF17205 PSI integrin Pfam 5.751E-3 1.110E-2
5.553E-2
4.773E-1
 1 9
42 IPR033760 Integin beta N InterPro 5.751E-3 1.110E-2
5.553E-2
4.773E-1
 1 9
43 IPR015812 Integrin bsu InterPro 5.751E-3 1.110E-2
5.553E-2
4.773E-1
 1 9
44 IPR018338 Carbonic anhydrase a-class CS InterPro 7.661E-3 1.445E-2
7.229E-2
6.359E-1
 1 12
45 PF00058 Ldl recept b Pfam 8.933E-3 1.562E-2
7.812E-2
7.414E-1
 1 14
46 PS51120 LDLRB PROSITE 8.933E-3 1.562E-2
7.812E-2
7.414E-1
 1 14
47 IPR023561 Carbonic anhydrase a-class InterPro 9.568E-3 1.562E-2
7.812E-2
7.942E-1
 1 15
48 PS00162 ALPHA CA 1 PROSITE 9.568E-3 1.562E-2
7.812E-2
7.942E-1
 1 15
49 SM00135 LY SMART 9.568E-3 1.562E-2
7.812E-2
7.942E-1
 1 15
50 IPR000033 LDLR classB rpt InterPro 9.568E-3 1.562E-2
7.812E-2
7.942E-1
 1 15
Show 45 more annotations

7: Pathway [Display Chart] 11 input genes in category / 128 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269950 Ion channel transport BioSystems: REACTOME 8.975E-9 1.049E-6 5.700E-6 1.149E-6 6 209
2 1269953 Stimuli-sensing channels BioSystems: REACTOME 1.639E-8 1.049E-6 5.700E-6 2.098E-6 5 104
3 147586 Collecting duct acid secretion BioSystems: KEGG 1.484E-6 6.330E-5 3.439E-4 1.899E-4 3 27
4 114229 Hypertrophic cardiomyopathy (HCM) BioSystems: KEGG 2.323E-3 4.094E-2
2.225E-1
2.973E-1
 2 83
5 PW:0000599 altered canonical Wnt signaling Pathway Ontology 4.411E-3 4.094E-2
2.225E-1
5.646E-1
 1 5
6 1268923 Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling BioSystems: REACTOME 5.291E-3 4.094E-2
2.225E-1
6.772E-1
 1 6
7 PW:0000036 nitrogen metabolic Pathway Ontology 6.170E-3 4.094E-2
2.225E-1
7.897E-1
 1 7
8 1270112 AMPK inhibits chREBP transcriptional activation activity BioSystems: REACTOME 7.048E-3 4.094E-2
2.225E-1
9.022E-1
 1 8
9 1269196 Cross-presentation of particulate exogenous antigens (phagosomes) BioSystems: REACTOME 7.048E-3 4.094E-2
2.225E-1
9.022E-1
 1 8
10 153910 Phagosome BioSystems: KEGG 7.770E-3 4.094E-2
2.225E-1
9.946E-1
 2 154
11 1270225 Erythrocytes take up oxygen and release carbon dioxide BioSystems: REACTOME 7.926E-3 4.094E-2
2.225E-1
1.000E0
 1 9
12 1268924 RNF mutants show enhanced WNT signaling and proliferation BioSystems: REACTOME 7.926E-3 4.094E-2
2.225E-1
1.000E0
 1 9
13 1268840 Activation of PPARGC1A (PGC-1alpha) by phosphorylation BioSystems: REACTOME 8.803E-3 4.094E-2
2.225E-1
1.000E0
 1 10
14 SMP00078 Chlorothiazide Pathway SMPDB 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
15 SMP00081 Methyclothiazide Pathway SMPDB 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
16 1270014 Import of palmitoyl-CoA into the mitochondrial matrix BioSystems: REACTOME 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
17 SMP00108 Hydroflumethiazide Pathway SMPDB 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
18 SMP00100 Hydrochlorothiazide Pathway SMPDB 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
19 SMP00121 Trichlormethiazide Pathway SMPDB 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
20 M18053 Reversal of Insulin Resistance by Leptin MSigDB C2 BIOCARTA (v6.0) 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
21 SMP00110 Indapamide Pathway SMPDB 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
22 SMP00080 Polythiazide Pathway SMPDB 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
23 SMP00105 Metolazone Pathway SMPDB 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
24 SMP00090 Bendroflumethiazide Pathway SMPDB 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
25 SMP00122 Chlorthalidone Pathway SMPDB 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
26 SMP00103 Cyclothiazide Pathway SMPDB 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
27 SMP00091 Quinethazone Pathway SMPDB 9.680E-3 4.094E-2
2.225E-1
1.000E0
 1 11
28 PW:0000542 adenosine monophosphate-activated protein kinase (AMPK) signaling Pathway Ontology 1.056E-2 4.094E-2
2.225E-1
1.000E0
 1 12
29 SMP00115 Furosemide Pathway SMPDB 1.056E-2 4.094E-2
2.225E-1
1.000E0
 1 12
30 SMP00097 Ethacrynic Acid pathway SMPDB 1.056E-2 4.094E-2
2.225E-1
1.000E0
 1 12
31 SMP00118 Torsemide Pathway SMPDB 1.056E-2 4.094E-2
2.225E-1
1.000E0
 1 12
32 SMP00088 Bumetanide Pathway SMPDB 1.056E-2 4.094E-2
2.225E-1
1.000E0
 1 12
33 1270229 Reversible hydration of carbon dioxide BioSystems: REACTOME 1.056E-2 4.094E-2
2.225E-1
1.000E0
 1 12
34 1270223 O2/CO2 exchange in erythrocytes BioSystems: REACTOME 1.143E-2 4.180E-2
2.271E-1
1.000E0
 1 13
35 1270224 Erythrocytes take up carbon dioxide and release oxygen BioSystems: REACTOME 1.143E-2 4.180E-2
2.271E-1
1.000E0
 1 13
36 1269608 Negative regulation of TCF-dependent signaling by WNT ligand antagonists BioSystems: REACTOME 1.318E-2 4.686E-2
2.546E-1
1.000E0
 1 15
Show 31 more annotations

8: Pubmed [Display Chart] 12 input genes in category / 1509 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 23115349 Changing expression of chloride channels during preimplantation mouse development. Pubmed 7.030E-13 1.061E-9 8.377E-9 1.061E-9 4 9
2 15706348 Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration. Pubmed 2.370E-11 1.788E-8 1.412E-7 3.576E-8 3 3
3 19507210 A single-center experience in 20 patients with infantile malignant osteopetrosis. Pubmed 9.476E-11 4.767E-8 3.764E-7 1.430E-7 3 4
4 19371798 The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis. Pubmed 1.988E-9 7.501E-7 5.923E-6 3.000E-6 3 9
5 16985003 Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Pubmed 7.669E-8 5.462E-6 4.313E-5 1.157E-4 4 137
6 11014860 Cl(-) channels in basolateral TAL membranes XV. Molecular heterogeneity between cortical and medullary channels. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
7 14584882 Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
8 24108692 CLCN7 and TCIRG1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
9 20805576 A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
10 25919862 Associations between CLCNKA B tag SNPs with essential hypertension and interactions between genetic and environmental factors in an island population in China. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
11 24820037 Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
12 27335120 The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
13 8812470 Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
14 20430974 Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
15 21527911 ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
16 8544406 Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
17 9916798 Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
18 24863058 Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
19 12054167 Localization of the gene causing autosomal dominant osteopetrosis type I to chromosome 11q12-13. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
20 8041726 Two highly homologous members of the ClC chloride channel family in both rat and human kidney. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
21 20424301 Novel mutations in Indian patients with autosomal recessive infantile malignant osteopetrosis. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
22 12566520 A phenocopy of CAII deficiency: a novel genetic explanation for inherited infantile osteopetrosis with distal renal tubular acidosis. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
23 9916791 Kidney kinetics and chloride ion pumps. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
24 18648499 A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
25 16525474 ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function. Pubmed 9.049E-8 5.462E-6 4.313E-5 1.366E-4 2 2
26 18094726 Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance. Pubmed 2.714E-7 1.241E-5 9.801E-5 4.096E-4 2 3
27 17510212 Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension. Pubmed 2.714E-7 1.241E-5 9.801E-5 4.096E-4 2 3
28 17105730 The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor. Pubmed 2.714E-7 1.241E-5 9.801E-5 4.096E-4 2 3
29 16849430 Barttin modulates trafficking and function of ClC-K channels. Pubmed 2.714E-7 1.241E-5 9.801E-5 4.096E-4 2 3
30 21107136 Distinct neuropathologic phenotypes after disrupting the chloride transport proteins ClC-6 or ClC-7/Ostm1. Pubmed 2.714E-7 1.241E-5 9.801E-5 4.096E-4 2 3
31 11734858 Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion. Pubmed 2.714E-7 1.241E-5 9.801E-5 4.096E-4 2 3
32 26013830 Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional. Pubmed 2.714E-7 1.241E-5 9.801E-5 4.096E-4 2 3
33 10982849 Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor. Pubmed 2.714E-7 1.241E-5 9.801E-5 4.096E-4 2 3
34 17110406 Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters. Pubmed 5.428E-7 2.214E-5 1.748E-4 8.190E-4 2 4
35 27187610 The use of whole exome sequencing for the diagnosis of autosomal recessive malignant infantile osteopetrosis. Pubmed 5.428E-7 2.214E-5 1.748E-4 8.190E-4 2 4
36 17652939 Haplotype diversity in four genes (CLCNKA, CLCNKB, BSND, NEDD4L) involved in renal salt reabsorption. Pubmed 5.428E-7 2.214E-5 1.748E-4 8.190E-4 2 4
37 15044642 Salt wasting and deafness resulting from mutations in two chloride channels. Pubmed 5.428E-7 2.214E-5 1.748E-4 8.190E-4 2 4
38 11423561 Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney. Pubmed 1.899E-6 7.540E-5 5.954E-4 2.865E-3 2 7
39 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 4.624E-6 1.789E-4 1.413E-3 6.978E-3 4 383
40 26598607 Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking. Pubmed 1.381E-5 5.209E-4 4.113E-3 2.083E-2 2 18
41 17543594 Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross. Pubmed 3.405E-5 7.162E-4 5.656E-3
5.138E-2
 2 28
42 25798587 Ion channel expression in the developing enteric nervous system. Pubmed 5.667E-5 7.162E-4 5.656E-3
8.552E-2
 2 36
43 20359476 Genetic evidence that SOST inhibits WNT signaling in the limb. Pubmed 8.498E-5 7.162E-4 5.656E-3
1.282E-1
 2 44
44 26273529 High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Pubmed 1.283E-4 7.162E-4 5.656E-3
1.936E-1
 2 54
45 14502078 Expression of CLC-KB gene promoter in the mouse cochlea. Pubmed 3.142E-4 7.162E-4 5.656E-3
4.741E-1
 1 1
46 24103576 ClC-7 expression levels critically regulate bone turnover, but not gastric acid secretion. Pubmed 3.142E-4 7.162E-4 5.656E-3
4.741E-1
 1 1
47 6440531 Novel carbonic anhydrase (Car-2) allele in Spanish mice. Pubmed 3.142E-4 7.162E-4 5.656E-3
4.741E-1
 1 1
48 25421907 CLC-3 channels in cancer (review). Pubmed 3.142E-4 7.162E-4 5.656E-3
4.741E-1
 1 1
49 16522634 Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration. Pubmed 3.142E-4 7.162E-4 5.656E-3
4.741E-1
 1 1
50 17562318 The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface. Pubmed 3.142E-4 7.162E-4 5.656E-3
4.741E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 11 input genes in category / 267 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:OSTM1 OSTM1 interactions 3.669E-5 3.874E-3 2.389E-2 9.797E-3 2 15
2 int:ATP6AP2 ATP6AP2 interactions 3.816E-5 3.874E-3 2.389E-2 1.019E-2 3 111
3 int:LGALS8 LGALS8 interactions 4.353E-5 3.874E-3 2.389E-2 1.162E-2 3 116
4 int:FAM177A1 FAM177A1 interactions 1.315E-4 7.669E-3 4.729E-2 3.512E-2 2 28
5 int:BIRC7 BIRC7 interactions 1.616E-4 7.669E-3 4.729E-2 4.315E-2 2 31
6 int:CLCN7 CLCN7 interactions 1.723E-4 7.669E-3 4.729E-2 4.601E-2 2 32
7 int:ADAM33 ADAM33 interactions 2.982E-4 1.137E-2
7.013E-2
7.961E-2
 2 42
8 int:SLC33A1 SLC33A1 interactions 6.296E-4 2.101E-2
1.296E-1
1.681E-1
 2 61
9 int:ST8SIA4 ST8SIA4 interactions 7.592E-4 2.252E-2
1.389E-1
2.027E-1
 2 67
10 int:SCGB1D1 SCGB1D1 interactions 9.252E-4 2.470E-2
1.523E-1
2.470E-1
 2 74
11 int:LGALS9 LGALS9 interactions 1.054E-3 2.557E-2
1.577E-1
2.813E-1
 2 79
12 int:CLCNKA CLCNKA interactions 1.242E-3 2.764E-2
1.705E-1
3.317E-1
 1 2
13 int:TIMD4 TIMD4 interactions 1.863E-3 3.826E-2
2.359E-1
4.974E-1
 1 3
14 int:LYPD3 LYPD3 interactions 2.408E-3 4.592E-2
2.832E-1
6.429E-1
 2 120
15 int:DKK4 DKK4 interactions 3.103E-3 4.603E-2
2.839E-1
8.286E-1
 1 5
16 int:ALOX5AP ALOX5AP interactions 3.103E-3 4.603E-2
2.839E-1
8.286E-1
 1 5
17 int:CLIC6 CLIC6 interactions 3.103E-3 4.603E-2
2.839E-1
8.286E-1
 1 5
18 int:SLC4A3 SLC4A3 interactions 3.103E-3 4.603E-2
2.839E-1
8.286E-1
 1 5
19 int:DISP3 DISP3 interactions 3.723E-3 4.733E-2
2.919E-1
9.940E-1
 1 6
20 int:CHST9 CHST9 interactions 3.723E-3 4.733E-2
2.919E-1
9.940E-1
 1 6
21 int:MFGE8 MFGE8 interactions 3.723E-3 4.733E-2
2.919E-1
9.940E-1
 1 6
22 int:NTF4 NTF4 interactions 4.342E-3 4.831E-2
2.979E-1
1.000E0
 1 7
23 int:CAPRIN2 CAPRIN2 interactions 4.342E-3 4.831E-2
2.979E-1
1.000E0
 1 7
24 int:PODN PODN interactions 4.342E-3 4.831E-2
2.979E-1
1.000E0
 1 7
Show 19 more annotations

10: Cytoband [Display Chart] 12 input genes in category / 11 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1p36 1p36 1.443E-4 1.587E-3 4.794E-3 1.587E-3 2 52
2 4q33 4q33 4.147E-3 1.292E-2 3.900E-2 4.562E-2 1 12
3 16p13 16p13 4.492E-3 1.292E-2 3.900E-2 4.941E-2 1 13
4 8q22 8q22 5.182E-3 1.292E-2 3.900E-2
5.700E-2
 1 15
5 21q22.12 21q22.12 5.871E-3 1.292E-2 3.900E-2
6.458E-2
 1 17
6 3q21.2 3q21.2 7.591E-3 1.392E-2 4.203E-2
8.350E-2
 1 22
7 11q13.2 11q13.2 1.718E-2 2.699E-2
8.151E-2
1.889E-1
 1 50
8 11q13.4 11q13.4 2.566E-2 3.261E-2
9.846E-2
2.823E-1
 1 75
9 7q36.1 7q36.1 2.668E-2 3.261E-2
9.846E-2
2.934E-1
 1 78
10 6q21 6q21 3.509E-2 3.860E-2
1.166E-1
3.860E-1
 1 103
Show 5 more annotations

11: Transcription Factor Binding Site [Display Chart] 9 input genes in category / 96 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 10 input genes in category / 7 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 302 Chloride voltage-gated channels genenames.org 9.647E-12 6.753E-11 1.751E-10 6.753E-11 4 10
2 307 Chloride intracellular channels genenames.org 4.074E-6 1.426E-5 3.697E-5 2.852E-5 2 6
3 1159 Integrin beta subunits genenames.org 4.937E-3 1.152E-2 2.987E-2 3.456E-2 1 9
4 634 Low density lipoprotein receptors genenames.org 7.124E-3 1.247E-2 3.233E-2 4.987E-2 1 13
5 460 Carbonic anhydrases genenames.org 9.852E-3 1.379E-2 3.576E-2
6.896E-2
 1 18
6 415 V-type ATPases genenames.org 1.257E-2 1.467E-2 3.803E-2
8.801E-2
 1 23
Show 1 more annotation

13: Coexpression [Display Chart] 12 input genes in category / 1333 annotations before applied cutoff / 23137 genes in category

No results to display

14: Coexpression Atlas [Display Chart] 12 input genes in category / 1357 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney Normal RCC EN-U/Kidney Normal RCC EN17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney Normal RCC EN-U/Kidney Normal RCC EN17 Adult, Development, and Cancer types 2.897E-5 1.327E-2
1.034E-1
 3.932E-2 2 15
2 10X Human 68K PBMC CD34+ Subtype CD34+-CD34+ c8 Top 200 Genes 10X Human 68K PBMC CD34+ Subtype CD34+-CD34+ c8 Top 200 Genes 3.765E-5 1.327E-2
1.034E-1
5.109E-2
 4 374
3 gudmap developingLowerUrinaryTract e13.5 bladder epithelial cells 500 DevelopingLowerUrinaryTract e13.5 bladder epithelial cells emap-30875 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.568E-5 1.327E-2
1.034E-1
6.199E-2
 4 393
4 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type B3/4/2 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type B3/4/2 TCGA-Thymus 4.994E-5 1.327E-2
1.034E-1
6.777E-2
 3 136
5 gudmap developingLowerUrinaryTract e13.5 bladder epithelial cells 500 k2 DevelopingLowerUrinaryTract e13.5 bladder epithelial cells emap-30875 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.554E-5 1.327E-2
1.034E-1
8.894E-2
 3 149
6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal Wilms Normal cell/Kidney Normal Wilms T14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal Wilms Normal cell/Kidney Normal Wilms T14 Adult, Development, and Cancer types 1.111E-4 1.327E-2
1.034E-1
1.508E-1
 3 178
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Cortex Wilms NK cell/Kidney Normal-Cortex Wilms NK16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Cortex Wilms NK cell/Kidney Normal-Cortex Wilms NK16 Adult, Development, and Cancer types 1.148E-4 1.327E-2
1.034E-1
1.558E-1
 3 180
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Medulla post-natal kidney NK cell/Kidney Normal-Medulla post-natal kidney NK14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Medulla post-natal kidney NK cell/Kidney Normal-Medulla post-natal kidney NK14 Adult, Development, and Cancer types 1.167E-4 1.327E-2
1.034E-1
1.584E-1
 3 181
9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Cortex post-natal kidney NK cell/Kidney Normal-Cortex post-natal kidney NK16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Cortex post-natal kidney NK cell/Kidney Normal-Cortex post-natal kidney NK16 Adult, Development, and Cancer types 1.167E-4 1.327E-2
1.034E-1
1.584E-1
 3 181
10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Wilms tumour/Kidney Normal-Medulla post-natal kidney Wilms tumour/Kidney Normal-Medulla post-natal kidney T16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Wilms tumour/Kidney Normal-Medulla post-natal kidney Wilms tumour/Kidney Normal-Medulla post-natal kidney T16 Adult, Development, and Cancer types 1.187E-4 1.327E-2
1.034E-1
1.610E-1
 3 182
11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Proliferating NK cell/Kidney Normal-Cortex post-natal kidney Proliferating NK cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Proliferating NK cell/Kidney Normal-Cortex post-natal kidney Proliferating NK cell Adult, Development, and Cancer types 1.187E-4 1.327E-2
1.034E-1
1.610E-1
 3 182
12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal-Medulla Wilms PT-U/Kidney Normal-Medulla Wilms PT16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal-Medulla Wilms PT-U/Kidney Normal-Medulla Wilms PT16 Adult, Development, and Cancer types 1.187E-4 1.327E-2
1.034E-1
1.610E-1
 3 182
13 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Cortex Wilms Nephron epithelium/Kidney Normal-Cortex Wilms N17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Cortex Wilms Nephron epithelium/Kidney Normal-Cortex Wilms N17 Adult, Development, and Cancer types 1.348E-4 1.327E-2
1.034E-1
1.829E-1
 3 190
14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Plasmacytoid DC/Kidney Normal-Cortex Wilms Plasmacytoid DC Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Plasmacytoid DC/Kidney Normal-Cortex Wilms Plasmacytoid DC Adult, Development, and Cancer types 1.369E-4 1.327E-2
1.034E-1
1.857E-1
 3 191
15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Mast cell/Kidney Normal RCC Mast cell/Kidney Normal RCC IT16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Mast cell/Kidney Normal RCC Mast cell/Kidney Normal RCC IT16 Adult, Development, and Cancer types 4.658E-4 4.214E-2
3.283E-1
6.321E-1
 2 59
16 gudmap developingLowerUrinaryTract e13.5 bladder epithelial cells 200 k4 DevelopingLowerUrinaryTract e13.5 bladder epithelial cells emap-30875 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.311E-4 4.504E-2
3.509E-1
7.206E-1
 2 63
Show 11 more annotations

15: Computational [Display Chart] 10 input genes in category / 131 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M15002 MODULE 396 Genes in the cancer module 396. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.866E-5 7.684E-3 4.193E-2 7.684E-3 2 12
2 M10181 MODULE 416 Genes in the cancer module 416. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.235E-4 1.464E-2
7.989E-2
 2.928E-2 2 23
3 M5770 MODULE 63 Porins / transporters. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.855E-4 4.303E-2
2.348E-1
1.291E-1
 3 211

16: MicroRNA [Display Chart] 12 input genes in category / 312 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 AATGTGA,MIR-23B:MSigDB AATGTGA,MIR-23B:MSigDB MSigDB 3.467E-5 5.408E-3 3.419E-2 1.082E-2 3 396
2 AATGTGA,MIR-23A:MSigDB AATGTGA,MIR-23A:MSigDB MSigDB 3.467E-5 5.408E-3 3.419E-2 1.082E-2 3 396
3 hsa-miR-183-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.727E-4 1.797E-2
1.136E-1
5.390E-2
 2 118
4 hsa-miR-1279:PITA hsa-miR-1279:PITA TOP PITA 6.980E-4 3.515E-2
2.222E-1
2.178E-1
 2 238
5 hsa-miR-125a-5p:Functional MTI Functional MTI miRTarbase 8.961E-4 3.515E-2
2.222E-1
2.796E-1
 2 270
6 hsa-miR-8055:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.238E-3 3.515E-2
2.222E-1
3.863E-1
 2 318
7 hsa-miR-421:TargetScan hsa-miR-421 TargetScan 1.348E-3 3.515E-2
2.222E-1
4.206E-1
 2 332
8 hsa-miR-524-3p:mirSVR lowEffct hsa-miR-524-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.994E-3 3.515E-2
2.222E-1
6.220E-1
 2 405
9 hsa-miR-199a-5p:TargetScan hsa-miR-199a-5p TargetScan 2.161E-3 3.515E-2
2.222E-1
6.744E-1
 2 422
10 hsa-miR-199b-5p:TargetScan hsa-miR-199b-5p TargetScan 2.161E-3 3.515E-2
2.222E-1
6.744E-1
 2 422
11 hsa-miR-525-3p:mirSVR lowEffct hsa-miR-525-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.243E-3 3.515E-2
2.222E-1
6.997E-1
 2 430
12 hsa-miR-302e:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.431E-3 3.515E-2
2.222E-1
7.583E-1
 2 448
13 hsa-miR-520d-3p:Functional MTI Functional MTI miRTarbase 2.441E-3 3.515E-2
2.222E-1
7.616E-1
 2 449
14 hsa-miR-520e:Functional MTI Functional MTI miRTarbase 2.484E-3 3.515E-2
2.222E-1
7.750E-1
 2 453
15 hsa-miR-520a-3p:Functional MTI Functional MTI miRTarbase 2.506E-3 3.515E-2
2.222E-1
7.817E-1
 2 455
16 hsa-miR-520c-3p:Functional MTI Functional MTI miRTarbase 2.506E-3 3.515E-2
2.222E-1
7.817E-1
 2 455
17 hsa-miR-520b:Functional MTI Functional MTI miRTarbase 2.506E-3 3.515E-2
2.222E-1
7.817E-1
 2 455
18 hsa-miR-302d-3p:Functional MTI Functional MTI miRTarbase 2.560E-3 3.515E-2
2.222E-1
7.986E-1
 2 460
19 hsa-miR-302b-3p:Functional MTI Functional MTI miRTarbase 2.560E-3 3.515E-2
2.222E-1
7.986E-1
 2 460
20 hsa-miR-372-3p:Non-Functional MTI Non-Functional MTI miRTarbase 2.571E-3 3.515E-2
2.222E-1
8.021E-1
 2 461
21 hsa-miR-302a-3p:Functional MTI Functional MTI miRTarbase 2.615E-3 3.515E-2
2.222E-1
8.157E-1
 2 465
22 hsa-miR-1825:mirSVR highEffct hsa-miR-1825:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.794E-3 3.515E-2
2.222E-1
8.716E-1
 2 481
23 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 2.816E-3 3.515E-2
2.222E-1
8.787E-1
 2 483
24 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 2.816E-3 3.515E-2
2.222E-1
8.787E-1
 2 483
25 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 2.816E-3 3.515E-2
2.222E-1
8.787E-1
 2 483
Show 20 more annotations

17: Drug [Display Chart] 12 input genes in category / 3300 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000070769 1-phenylpyrazole Stitch 1.757E-15 5.800E-12 5.034E-11 5.800E-12 6 28
2 CID000157920 lubiprostone Stitch 3.785E-14 6.245E-11 5.420E-10 1.249E-10 6 45
3 CID000011502 trans-1,2-diphenylethylene Stitch 5.982E-14 6.580E-11 5.711E-10 1.974E-10 7 117
4 CID000003352 fipronil Stitch 2.571E-13 2.121E-10 1.841E-9 8.484E-10 6 61
5 CID000004816 picrotoxinine Stitch 3.821E-13 2.522E-10 2.189E-9 1.261E-9 6 65
6 CID000002766 trans-4-aminocrotonic acid Stitch 4.615E-13 2.538E-10 2.203E-9 1.523E-9 6 67
7 CID000065243 BN 52021 Stitch 7.861E-13 3.706E-10 3.216E-9 2.594E-9 6 73
8 CID000104781 TBPS Stitch 2.325E-12 9.589E-10 8.322E-9 7.671E-9 6 87
9 CID000040600 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid Stitch 3.341E-12 1.225E-9 1.063E-8 1.102E-8 7 206
10 CID006435110 ivermectin Stitch 5.815E-12 1.803E-9 1.565E-8 1.919E-8 6 101
11 CID000002423 AC1L1DN5 Stitch 6.178E-12 1.803E-9 1.565E-8 2.039E-8 6 102
12 CID000002254 AC1L1D9R Stitch 6.558E-12 1.803E-9 1.565E-8 2.164E-8 6 103
13 CID000003048 endrine Stitch 7.819E-12 1.985E-9 1.723E-8 2.580E-8 6 106
14 CID000004630 oxotremorine Stitch 8.767E-12 2.066E-9 1.794E-8 2.893E-8 6 108
15 CID000001233 ibotenic acid Stitch 1.846E-11 4.061E-9 3.525E-8 6.092E-8 6 122
16 CID000004488 niflumic acid Stitch 2.141E-11 4.415E-9 3.832E-8 7.064E-8 6 125
17 CID000003440 furosemide Stitch 2.367E-11 4.594E-9 3.987E-8 7.810E-8 7 272
18 CID000003661 atropine sulfate Stitch 1.305E-10 2.392E-8 2.076E-7 4.305E-7 7 347
19 CID005287709 AC1NRA5C Stitch 1.595E-10 2.770E-8 2.404E-7 5.262E-7 6 174
20 CID000031304 picrotoxin Stitch 2.024E-10 3.340E-8 2.898E-7 6.679E-7 6 181
21 CID000000838 L-adrenaline Stitch 7.518E-10 1.181E-7 1.025E-6 2.481E-6 7 446
22 CID000001123 taurine Stitch 8.807E-10 1.321E-7 1.147E-6 2.906E-6 6 231
23 CID000002376 AC1Q3ZOL Stitch 1.711E-9 2.455E-7 2.130E-6 5.646E-6 6 258
24 CID000024085 HgCl2 Stitch 1.920E-9 2.639E-7 2.291E-6 6.335E-6 6 263
25 ctd:D017878 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid CTD 2.008E-9 2.650E-7 2.300E-6 6.626E-6 4 34
26 ctd:C104536 xanthohumol CTD 1.361E-8 1.728E-6 1.500E-5 4.493E-5 4 54
27 CID000003488 glibenclamide Stitch 1.786E-8 2.183E-6 1.895E-5 5.894E-5 6 382
28 CID011979316 vasopressin Stitch 1.960E-8 2.310E-6 2.004E-5 6.467E-5 6 388
29 CID000000119 gamma-aminobutyric acid Stitch 6.433E-8 7.320E-6 6.353E-5 2.123E-4 6 474
30 CID000000875 tartarate Stitch 1.528E-7 1.681E-5 1.459E-4 5.044E-4 5 266
31 CID000000767 bicarbonate Stitch 4.127E-7 4.393E-5 3.813E-4 1.362E-3 5 325
32 CID000004549 5-nitro-2-(3-phenylpropylamino)benzoic acid Stitch 2.413E-6 2.489E-4 2.160E-3 7.963E-3 3 52
33 ctd:D008456 2-Methyl-4-chlorophenoxyacetic Acid CTD 2.528E-6 2.528E-4 2.194E-3 8.343E-3 2 5
34 CID000002471 bumetanide Stitch 3.183E-6 3.090E-4 2.682E-3 1.051E-2 4 209
35 CID000015617 1,2-dimethylimidazole Stitch 7.072E-6 6.668E-4 5.787E-3 2.334E-2 2 8
36 CID000446591 AC1O6W2C Stitch 7.323E-6 6.713E-4 5.826E-3 2.417E-2 3 75
37 CID000410009 AC1L8Y60 Stitch 1.227E-5 1.094E-3 9.494E-3 4.048E-2 3 89
38 CID000032765 leptophos-oxon Stitch 2.294E-5 1.993E-3 1.729E-2
7.572E-2
 2 14
39 ctd:C540355 1-anilino-4-methyl-2-methylthio-4-phenylimidazolin-5-one CTD 3.123E-5 2.642E-3 2.293E-2
1.031E-1
 4 373
40 CID000004788 phloretin Stitch 3.906E-5 3.222E-3 2.797E-2
1.289E-1
 3 131
41 CID005359238 cyanyl Stitch 4.782E-5 3.849E-3 3.341E-2
1.578E-1
 2 20
42 CID000016421 map J Stitch 6.939E-5 5.437E-3 4.719E-2
2.290E-1
 2 24
43 6133 DN Verteporfin [129497-78-5]; Down 200; 2.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 7.085E-5 5.437E-3 4.719E-2
2.338E-1
 3 160
44 CID000030709 leptophos Stitch 7.540E-5 5.655E-3 4.908E-2
2.488E-1
 2 25
45 7062 UP GW8510; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.217E-4 8.547E-3
7.418E-2
4.015E-1
 3 192
46 2864 DN Dosulepin hydrochloride [897-15-4]; Down 200; 12uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.274E-4 8.547E-3
7.418E-2
4.203E-1
 3 195
47 2183 DN Isosorbide dinitrate [87-33-2]; Down 200; 17uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.293E-4 8.547E-3
7.418E-2
4.267E-1
 3 196
48 3025 DN Acetaminophen [103-90-2]; Down 200; 26.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.293E-4 8.547E-3
7.418E-2
4.267E-1
 3 196
49 5015 DN Benzbromarone [3562-84-3]; Down 200; 9.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.293E-4 8.547E-3
7.418E-2
4.267E-1
 3 196
50 CID000121920 Ins(3,4,5,6)P4 Stitch 1.324E-4 8.547E-3
7.418E-2
4.369E-1
 2 33
Show 45 more annotations

18: Disease [Display Chart] 12 input genes in category / 469 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 OMIN:259700 OSTEOPETROSIS, AUTOSOMAL RECESSIVE 1; OPTB1 OMIM 3.102E-10 1.265E-7 8.513E-7 1.455E-7 3 3
2 C0029454 Osteopetrosis DisGeNET Curated 5.395E-10 1.265E-7 8.513E-7 2.530E-7 5 62
3 C0271344 Compression of optic nerve DisGeNET Curated 1.084E-8 1.695E-6 1.140E-5 5.084E-6 3 7
4 C0151825 Bone pain DisGeNET Curated 3.296E-8 3.580E-6 2.409E-5 1.546E-5 4 48
5 C3806283 Frequent fractures DisGeNET Curated 5.344E-8 3.580E-6 2.409E-5 2.506E-5 4 54
6 C3805574 Increased fracture rate DisGeNET Curated 5.344E-8 3.580E-6 2.409E-5 2.506E-5 4 54
7 C1833752 Varying degree of multiple fractures DisGeNET Curated 5.344E-8 3.580E-6 2.409E-5 2.506E-5 4 54
8 C1318518 Infantile malignant osteopetrosis DisGeNET Curated 1.124E-7 6.590E-6 4.434E-5 5.272E-5 3 14
9 OMIN:613090 BARTTER SYNDROME, TYPE 4B OMIM 5.027E-7 2.143E-5 1.442E-4 2.358E-4 2 2
10 cv:C2751312 Bartter syndrome, type 4b Clinical Variations 5.027E-7 2.143E-5 1.442E-4 2.358E-4 2 2
11 C1850127 Osteopetrosis, Autosomal Recessive 1 DisGeNET Curated 5.027E-7 2.143E-5 1.442E-4 2.358E-4 2 2
12 C2674432 Decreased bone mineral density Z score DisGeNET Curated 1.378E-6 4.456E-5 2.999E-4 6.465E-4 3 31
13 OMIN:602522 BARTTER SYNDROME, TYPE 4A OMIM 1.507E-6 4.456E-5 2.999E-4 7.070E-4 2 3
14 C0740896 Hypokalemic hypochloremic metabolic alkalosis DisGeNET Curated 1.507E-6 4.456E-5 2.999E-4 7.070E-4 2 3
15 C1865270 BARTTER SYNDROME, TYPE 4A DisGeNET Curated 1.507E-6 4.456E-5 2.999E-4 7.070E-4 2 3
16 C1842083 Abnormality of the ribs DisGeNET Curated 1.520E-6 4.456E-5 2.999E-4 7.130E-4 3 32
17 C0235942 Skull malformation DisGeNET Curated 2.579E-6 7.116E-5 4.788E-4 1.210E-3 3 38
18 C1839866 Elevated serum acid phosphatase DisGeNET Curated 3.014E-6 7.450E-5 5.013E-4 1.413E-3 2 4
19 C4021611 Abnormality of epiphysis morphology DisGeNET Curated 3.018E-6 7.450E-5 5.013E-4 1.416E-3 3 40
20 C0005940 Bone Diseases DisGeNET Curated 3.566E-6 8.120E-5 5.464E-4 1.672E-3 4 153
21 C0242567 Opsoclonus DisGeNET Curated 5.021E-6 8.120E-5 5.464E-4 2.355E-3 2 5
22 C4280476 Increased bone density in skeletal bones DisGeNET Curated 5.021E-6 8.120E-5 5.464E-4 2.355E-3 2 5
23 C1843331 Diffuse, symmetrical osteosclerosis DisGeNET Curated 5.021E-6 8.120E-5 5.464E-4 2.355E-3 2 5
24 C4072880 Abnormality of hair consistency DisGeNET Curated 5.021E-6 8.120E-5 5.464E-4 2.355E-3 2 5
25 C1846352 Increased urinary chloride DisGeNET Curated 5.021E-6 8.120E-5 5.464E-4 2.355E-3 2 5
26 C4073290 Abnormality of hair volume DisGeNET Curated 5.021E-6 8.120E-5 5.464E-4 2.355E-3 2 5
27 C4072881 Abnormality of hair curl pattern DisGeNET Curated 5.021E-6 8.120E-5 5.464E-4 2.355E-3 2 5
28 C4023722 Abnormality of hair texture DisGeNET Curated 5.021E-6 8.120E-5 5.464E-4 2.355E-3 2 5
29 C1846351 Increased urinary potassium DisGeNET Curated 5.021E-6 8.120E-5 5.464E-4 2.355E-3 2 5
30 C0085680 Hypochloremia (disorder) DisGeNET Curated 7.528E-6 1.103E-4 7.424E-4 3.531E-3 2 6
31 C0595901 Serum chloride level decreased (finding) DisGeNET Curated 7.528E-6 1.103E-4 7.424E-4 3.531E-3 2 6
32 C3671887 Sodium concentration in urine above normal DisGeNET Curated 7.528E-6 1.103E-4 7.424E-4 3.531E-3 2 6
33 C1858719 Facial muscle weakness of muscles innervated by CN VII DisGeNET Curated 9.356E-6 1.205E-4 8.109E-4 4.388E-3 3 58
34 C0427055 Facial Paresis DisGeNET Curated 1.037E-5 1.205E-4 8.109E-4 4.862E-3 3 60
35 C4280530 Hypertrophy of cranial bones DisGeNET Curated 1.053E-5 1.205E-4 8.109E-4 4.941E-3 2 7
36 C1832451 Hyperostosis of cranial vault DisGeNET Curated 1.053E-5 1.205E-4 8.109E-4 4.941E-3 2 7
37 C0015469 Facial paralysis DisGeNET Curated 1.053E-5 1.205E-4 8.109E-4 4.941E-3 2 7
38 C4280528 Thick skull bones DisGeNET Curated 1.053E-5 1.205E-4 8.109E-4 4.941E-3 2 7
39 C4280529 Excessive growth of skull bones DisGeNET Curated 1.053E-5 1.205E-4 8.109E-4 4.941E-3 2 7
40 C4280531 Enlargement of skull bones DisGeNET Curated 1.053E-5 1.205E-4 8.109E-4 4.941E-3 2 7
41 C0853068 Glomerular filtration rate decreased DisGeNET Curated 1.053E-5 1.205E-4 8.109E-4 4.941E-3 2 7
42 C0376175 Bell Palsy DisGeNET Curated 1.090E-5 1.217E-4 8.189E-4 5.112E-3 3 61
43 C0520474 Aseptic Necrosis of Bone DisGeNET Curated 1.404E-5 1.372E-4 9.231E-4 6.585E-3 2 8
44 C0085660 Aseptic necrosis DisGeNET Curated 1.404E-5 1.372E-4 9.231E-4 6.585E-3 2 8
45 C0432252 Osteoporosis with pseudoglioma DisGeNET Curated 1.404E-5 1.372E-4 9.231E-4 6.585E-3 2 8
46 C0008711 Chronic rhinitis DisGeNET Curated 1.404E-5 1.372E-4 9.231E-4 6.585E-3 2 8
47 C0877326 Bone infarction DisGeNET Curated 1.404E-5 1.372E-4 9.231E-4 6.585E-3 2 8
48 C1865279 Fetal polyuria DisGeNET Curated 1.404E-5 1.372E-4 9.231E-4 6.585E-3 2 8
49 C0029445 Bone necrosis DisGeNET Curated 1.804E-5 1.727E-4 1.162E-3 8.463E-3 2 9
50 C1832160 Poor temperature regulation DisGeNET Curated 2.255E-5 2.115E-4 1.423E-3 1.057E-2 2 10
Show 45 more annotations