Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc208_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 14 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005112 Notch binding 2.101E-8 2.942E-7 9.565E-7 2.942E-7 3 20
2 GO:0008083 growth factor activity 1.356E-5 9.490E-5 3.086E-4 1.898E-4 3 166
3 GO:0005157 macrophage colony-stimulating factor receptor binding 9.643E-4 4.500E-3 1.463E-2 1.350E-2 1 3
4 GO:0038100 nodal binding 1.607E-3 5.624E-3 1.829E-2 2.249E-2 1 5
5 GO:0030957 Tat protein binding 2.570E-3 5.996E-3 1.950E-2 3.598E-2 1 8
6 GO:0070697 activin receptor binding 2.570E-3 5.996E-3 1.950E-2 3.598E-2 1 8
7 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 6.094E-3 1.122E-2 3.650E-2
8.532E-2
 1 19
8 GO:0033612 receptor serine/threonine kinase binding 6.414E-3 1.122E-2 3.650E-2
8.980E-2
 1 20
9 GO:0097110 scaffold protein binding 1.756E-2 2.731E-2
8.880E-2
2.458E-1
 1 55
Show 4 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 520 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042491 inner ear auditory receptor cell differentiation 3.340E-10 1.737E-7 1.187E-6 1.737E-7 4 42
2 GO:0035315 hair cell differentiation 6.868E-10 1.786E-7 1.220E-6 3.571E-7 4 50
3 GO:0060113 inner ear receptor cell differentiation 3.062E-9 5.308E-7 3.626E-6 1.592E-6 4 72
4 GO:0042490 mechanoreceptor differentiation 4.244E-9 5.517E-7 3.769E-6 2.207E-6 4 78
5 GO:0060563 neuroepithelial cell differentiation 7.594E-9 7.897E-7 5.396E-6 3.949E-6 4 90
6 GO:0007220 Notch receptor processing 1.039E-8 9.005E-7 6.152E-6 5.403E-6 3 16
7 GO:0002065 columnar/cuboidal epithelial cell differentiation 6.487E-8 4.819E-6 3.292E-5 3.373E-5 4 153
8 GO:0045747 positive regulation of Notch signaling pathway 1.438E-7 9.347E-6 6.386E-5 7.477E-5 3 37
9 GO:0009913 epidermal cell differentiation 1.904E-7 1.100E-5 7.516E-5 9.902E-5 4 200
10 GO:0048839 inner ear development 2.316E-7 1.204E-5 8.227E-5 1.204E-4 4 210
11 GO:0001709 cell fate determination 3.847E-7 1.685E-5 1.151E-4 2.001E-4 3 51
12 GO:0043583 ear development 3.889E-7 1.685E-5 1.151E-4 2.022E-4 4 239
13 GO:0045165 cell fate commitment 6.720E-7 2.688E-5 1.836E-4 3.494E-4 4 274
14 GO:0008593 regulation of Notch signaling pathway 1.146E-6 4.257E-5 2.908E-4 5.959E-4 3 73
15 GO:0008544 epidermis development 1.591E-6 5.515E-5 3.768E-4 8.272E-4 4 340
16 GO:0060120 inner ear receptor cell fate commitment 1.815E-6 5.553E-5 3.794E-4 9.440E-4 2 7
17 GO:0009912 auditory receptor cell fate commitment 1.815E-6 5.553E-5 3.794E-4 9.440E-4 2 7
18 GO:0042475 odontogenesis of dentin-containing tooth 2.309E-6 6.669E-5 4.556E-4 1.200E-3 3 92
19 GO:0030099 myeloid cell differentiation 2.693E-6 7.369E-5 5.035E-4 1.400E-3 4 388
20 GO:0061314 Notch signaling involved in heart development 3.888E-6 1.011E-4 6.907E-4 2.022E-3 2 10
21 GO:0072070 loop of Henle development 4.752E-6 1.177E-4 8.039E-4 2.471E-3 2 11
22 GO:0042476 odontogenesis 6.396E-6 1.512E-4 1.033E-3 3.326E-3 3 129
23 GO:0072148 epithelial cell fate commitment 1.321E-5 2.985E-4 2.040E-3 6.867E-3 2 18
24 GO:0007219 Notch signaling pathway 1.653E-5 3.582E-4 2.447E-3 8.596E-3 3 177
25 GO:0061311 cell surface receptor signaling pathway involved in heart development 2.380E-5 4.760E-4 3.252E-3 1.238E-2 2 24
26 GO:0097150 neuronal stem cell population maintenance 2.380E-5 4.760E-4 3.252E-3 1.238E-2 2 24
27 GO:0045637 regulation of myeloid cell differentiation 2.566E-5 4.941E-4 3.376E-3 1.334E-2 3 205
28 GO:0045665 negative regulation of neuron differentiation 3.479E-5 6.461E-4 4.414E-3 1.809E-2 3 227
29 GO:0003007 heart morphogenesis 4.752E-5 8.373E-4 5.721E-3 2.471E-2 3 252
30 GO:0001961 positive regulation of cytokine-mediated signaling pathway 4.831E-5 8.373E-4 5.721E-3 2.512E-2 2 34
31 GO:0060760 positive regulation of response to cytokine stimulus 5.123E-5 8.593E-4 5.871E-3 2.664E-2 2 35
32 GO:0050768 negative regulation of neurogenesis 6.855E-5 1.114E-3 7.611E-3 3.565E-2 3 285
33 GO:0090596 sensory organ morphogenesis 7.673E-5 1.209E-3 8.260E-3 3.990E-2 3 296
34 GO:0051961 negative regulation of nervous system development 8.719E-5 1.333E-3 9.110E-3 4.534E-2 3 309
35 GO:0048562 embryonic organ morphogenesis 1.022E-4 1.519E-3 1.038E-2
5.316E-2
 3 326
36 GO:0010721 negative regulation of cell development 1.305E-4 1.886E-3 1.288E-2
6.788E-2
 3 354
37 GO:0060411 cardiac septum morphogenesis 1.370E-4 1.925E-3 1.315E-2
7.123E-2
 2 57
38 GO:1903706 regulation of hemopoiesis 1.488E-4 2.032E-3 1.388E-2
7.738E-2
 3 370
39 GO:0060562 epithelial tube morphogenesis 1.524E-4 2.032E-3 1.388E-2
7.926E-2
 3 373
40 GO:0001947 heart looping 1.952E-4 2.538E-3 1.734E-2
1.015E-1
 2 68
41 GO:0035239 tube morphogenesis 2.090E-4 2.651E-3 1.811E-2
1.087E-1
 3 415
42 GO:0061371 determination of heart left/right asymmetry 2.189E-4 2.710E-3 1.852E-2
1.138E-1
 2 72
43 GO:0003143 embryonic heart tube morphogenesis 2.376E-4 2.873E-3 1.963E-2
1.235E-1
 2 75
44 GO:0048663 neuron fate commitment 2.570E-4 2.949E-3 2.015E-2
1.336E-1
 2 78
45 GO:0048568 embryonic organ development 3.192E-4 2.949E-3 2.015E-2
1.660E-1
 3 479
46 GO:0045445 myoblast differentiation 3.197E-4 2.949E-3 2.015E-2
1.662E-1
 2 87
47 GO:0021688 cerebellar molecular layer formation 3.222E-4 2.949E-3 2.015E-2
1.675E-1
 1 1
48 GO:0060611 mammary gland fat development 3.222E-4 2.949E-3 2.015E-2
1.675E-1
 1 1
49 GO:0021687 cerebellar molecular layer morphogenesis 3.222E-4 2.949E-3 2.015E-2
1.675E-1
 1 1
50 GO:0061444 endocardial cushion cell development 3.222E-4 2.949E-3 2.015E-2
1.675E-1
 1 1
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 11 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1990682 CSF1-CSF1R complex 6.295E-4 6.924E-3 2.091E-2 6.924E-3 1 2
2 GO:0016324 apical plasma membrane 4.409E-3 2.425E-2
7.322E-2
 4.850E-2 2 335
3 GO:0045177 apical part of cell 7.107E-3 2.480E-2
7.490E-2
7.818E-2
 2 428
4 GO:0005912 adherens junction 9.019E-3 2.480E-2
7.490E-2
9.921E-2
 2 484

4: Human Phenotype [Display Chart] 2 input genes in category / 258 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004617 Butterfly vertebral arch 4.249E-4 3.654E-2
2.241E-1
1.096E-1
 1 1
2 HP:0006571 Reduced number of intrahepatic bile ducts 4.249E-4 3.654E-2
2.241E-1
1.096E-1
 1 1
3 HP:0007702 Pigmentary retinal deposits 4.249E-4 3.654E-2
2.241E-1
1.096E-1
 1 1

5: Mouse Phenotype [Display Chart] 6 input genes in category / 827 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004400 abnormal cochlear outer hair cell number 7.772E-9 6.263E-6 4.569E-5 6.428E-6 4 51
2 MP:0006006 increased sensory neuron number 1.515E-8 6.263E-6 4.569E-5 1.253E-5 4 60
3 MP:0004406 abnormal cochlear hair cell number 2.681E-8 7.391E-6 5.393E-5 2.217E-5 4 69
4 MP:0004395 increased cochlear inner hair cell number 7.329E-8 1.515E-5 1.105E-4 6.061E-5 3 17
5 MP:0008947 increased neuron number 1.591E-7 2.632E-5 1.920E-4 1.316E-4 4 107
6 MP:0004393 abnormal cochlear inner hair cell morphology 3.077E-7 4.241E-5 3.094E-4 2.545E-4 4 126
7 MP:0004407 increased cochlear hair cell number 3.928E-7 4.641E-5 3.386E-4 3.248E-4 3 29
8 MP:0004394 abnormal cochlear inner hair cell number 5.860E-7 6.058E-5 4.420E-4 4.846E-4 3 33
9 MP:0004399 abnormal cochlear outer hair cell morphology 7.078E-7 6.504E-5 4.745E-4 5.854E-4 4 155
10 MP:0004300 abnormal organ of Corti supporting cell morphology 1.323E-6 1.094E-4 7.980E-4 1.094E-3 3 43
11 MP:0012024 abnormal nephron morphogenesis 1.678E-6 1.152E-4 8.401E-4 1.388E-3 2 4
12 MP:0002622 abnormal cochlear hair cell morphology 1.850E-6 1.152E-4 8.401E-4 1.530E-3 4 197
13 MP:0003308 abnormal cochlear sensory epithelium morphology 2.086E-6 1.152E-4 8.401E-4 1.725E-3 4 203
14 MP:0000045 abnormal hair cell morphology 2.170E-6 1.152E-4 8.401E-4 1.794E-3 4 205
15 MP:0000042 abnormal organ of Corti morphology 2.170E-6 1.152E-4 8.401E-4 1.794E-3 4 205
16 MP:0004408 decreased cochlear hair cell number 2.228E-6 1.152E-4 8.401E-4 1.843E-3 3 51
17 MP:0000972 abnormal mechanoreceptor morphology 3.376E-6 1.548E-4 1.129E-3 2.792E-3 4 229
18 MP:0003169 abnormal scala media morphology 3.556E-6 1.548E-4 1.129E-3 2.941E-3 4 232
19 MP:0004426 abnormal cochlear labyrinth morphology 3.556E-6 1.548E-4 1.129E-3 2.941E-3 4 232
20 MP:0000031 abnormal cochlea morphology 4.420E-6 1.828E-4 1.333E-3 3.655E-3 4 245
21 MP:0008137 absent podocytes 5.868E-6 2.271E-4 1.657E-3 4.853E-3 2 7
22 MP:0000035 abnormal membranous labyrinth morphology 6.042E-6 2.271E-4 1.657E-3 4.996E-3 4 265
23 MP:0000026 abnormal inner ear morphology 1.003E-5 3.487E-4 2.544E-3 8.292E-3 4 301
24 MP:0000034 abnormal inner ear vestibule morphology 1.012E-5 3.487E-4 2.544E-3 8.370E-3 3 84
25 MP:0004497 decreased organ of Corti supporting cell number 1.257E-5 4.098E-4 2.990E-3 1.039E-2 2 10
26 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology 1.288E-5 4.098E-4 2.990E-3 1.066E-2 3 91
27 MP:0004496 abnormal organ of Corti supporting cell number 1.842E-5 5.642E-4 4.116E-3 1.523E-2 2 12
28 MP:0004403 absent cochlear outer hair cells 2.176E-5 6.428E-4 4.690E-3 1.800E-2 2 13
29 MP:0004190 abnormal direction of embryo turning 4.263E-5 1.216E-3 8.870E-3 3.526E-2 2 18
30 MP:0004401 increased cochlear outer hair cell number 5.292E-5 1.459E-3 1.064E-2 4.376E-2 2 20
31 MP:0008948 decreased neuron number 5.651E-5 1.465E-3 1.069E-2 4.673E-2 4 466
32 MP:0004326 abnormal vestibular hair cell number 5.847E-5 1.465E-3 1.069E-2 4.836E-2 2 21
33 MP:0003148 decreased cochlear coiling 5.847E-5 1.465E-3 1.069E-2 4.836E-2 2 21
34 MP:0004405 absent cochlear hair cells 7.041E-5 1.667E-3 1.216E-2
5.823E-2
 2 23
35 MP:0002102 abnormal ear morphology 7.053E-5 1.667E-3 1.216E-2
5.833E-2
 4 493
36 MP:0004333 abnormal utricular macula morphology 8.345E-5 1.865E-3 1.361E-2
6.901E-2
 2 25
37 MP:0011290 decreased nephron number 8.345E-5 1.865E-3 1.361E-2
6.901E-2
 2 25
38 MP:0011289 abnormal nephron number 9.038E-5 1.967E-3 1.435E-2
7.474E-2
 2 26
39 MP:0000966 decreased sensory neuron number 1.401E-4 2.970E-3 2.167E-2
1.158E-1
 3 202
40 MP:0004402 decreased cochlear outer hair cell number 1.651E-4 3.413E-3 2.490E-2
1.365E-1
 2 35
41 MP:0006135 artery stenosis 1.747E-4 3.525E-3 2.571E-2
1.445E-1
 2 36
42 MP:0005412 vascular stenosis 2.271E-4 4.473E-3 3.263E-2
1.879E-1
 2 41
43 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles 2.618E-4 5.035E-3 3.673E-2
2.165E-1
 2 44
44 MP:0004532 abnormal inner hair cell stereociliary bundle morphology 2.740E-4 5.035E-3 3.673E-2
2.266E-1
 2 45
45 MP:0002623 abnormal vestibular hair cell morphology 2.740E-4 5.035E-3 3.673E-2
2.266E-1
 2 45
46 MP:0000272 abnormal aorta morphology 3.130E-4 5.628E-3 4.106E-2
2.589E-1
 3 265
47 MP:0002766 situs inversus 3.386E-4 5.827E-3 4.251E-2
2.800E-1
 2 50
48 MP:0001410 head bobbing 3.386E-4 5.827E-3 4.251E-2
2.800E-1
 2 50
49 MP:0006090 abnormal utricle morphology 3.523E-4 5.827E-3 4.251E-2
2.913E-1
 2 51
50 MP:0004252 abnormal direction of heart looping 3.523E-4 5.827E-3 4.251E-2
2.913E-1
 2 51
Show 45 more annotations

6: Domain [Display Chart] 6 input genes in category / 40 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00051 DSL SMART 7.300E-11 1.216E-9 5.205E-9 2.920E-9 3 4
2 PF01414 DSL Pfam 7.300E-11 1.216E-9 5.205E-9 2.920E-9 3 4
3 PS51051 DSL PROSITE 1.825E-10 1.216E-9 5.205E-9 7.299E-9 3 5
4 IPR011651 Notch ligand N InterPro 1.825E-10 1.216E-9 5.205E-9 7.299E-9 3 5
5 PF07657 MNNL Pfam 1.825E-10 1.216E-9 5.205E-9 7.299E-9 3 5
6 IPR001774 DSL InterPro 1.825E-10 1.216E-9 5.205E-9 7.299E-9 3 5
7 PF12661 hEGF Pfam 5.961E-8 3.406E-7 1.457E-6 2.384E-6 3 28
8 IPR026219 Jagged/Serrate InterPro 8.547E-8 4.274E-7 1.829E-6 3.419E-6 2 2
9 SM00181 EGF SMART 3.610E-7 1.444E-6 6.178E-6 1.444E-5 4 236
10 PS50026 EGF 3 PROSITE 3.610E-7 1.444E-6 6.178E-6 1.444E-5 4 236
11 IPR000742 EGF-like dom InterPro 4.547E-7 1.653E-6 7.074E-6 1.819E-5 4 250
12 PS00022 EGF 1 PROSITE 5.000E-7 1.665E-6 7.125E-6 2.000E-5 4 256
13 IPR013032 EGF-like CS InterPro 5.485E-7 1.665E-6 7.125E-6 2.194E-5 4 262
14 PS01186 EGF 2 PROSITE 5.828E-7 1.665E-6 7.125E-6 2.331E-5 4 266
15 IPR018097 EGF Ca-bd CS InterPro 2.661E-6 6.863E-6 2.937E-5 1.064E-4 3 97
16 PS01187 EGF CA PROSITE 2.830E-6 6.863E-6 2.937E-5 1.132E-4 3 99
17 PS00010 ASX HYDROXYL PROSITE 2.917E-6 6.863E-6 2.937E-5 1.167E-4 3 100
18 IPR000152 EGF-type Asp/Asn hydroxyl site InterPro 3.478E-6 7.728E-6 3.306E-5 1.391E-4 3 106
19 SM00179 EGF CA SMART 5.312E-6 1.115E-5 4.770E-5 2.125E-4 3 122
20 IPR001881 EGF-like Ca-bd dom InterPro 5.578E-6 1.115E-5 4.770E-5 2.231E-4 3 124
21 PF00008 EGF Pfam 5.853E-6 1.115E-5 4.770E-5 2.341E-4 3 126
22 IPR009030 Growth fac rcpt InterPro 1.112E-5 2.022E-5 8.651E-5 4.448E-4 3 156
23 SM00215 VWC out SMART 1.458E-5 2.536E-5 1.085E-4 5.832E-4 2 19
24 SM00214 VWC SMART 5.978E-5 9.964E-5 4.263E-4 2.391E-3 2 38
25 IPR001007 VWF dom InterPro 7.318E-5 1.171E-4 5.009E-4 2.927E-3 2 42
26 IPR013111 EGF extracell InterPro 1.500E-4 2.223E-4 9.511E-4 6.002E-3 2 60
27 PF07974 EGF 2 Pfam 1.500E-4 2.223E-4 9.511E-4 6.002E-3 2 60
28 PF07645 EGF CA Pfam 3.087E-4 4.132E-4 1.768E-3 1.235E-2 2 86
29 IPR008001 MCSF-1 InterPro 3.203E-4 4.132E-4 1.768E-3 1.281E-2 1 1
30 IPR033108 Jag2 InterPro 3.203E-4 4.132E-4 1.768E-3 1.281E-2 1 1
31 PF05337 CSF-1 Pfam 3.203E-4 4.132E-4 1.768E-3 1.281E-2 1 1
32 IPR029840 GFI1/1B InterPro 6.404E-4 8.005E-4 3.425E-3 2.562E-2 1 2
33 IPR019011 Cryptic/Cripto CFC-dom InterPro 9.605E-4 1.130E-3 4.835E-3 3.842E-2 1 3
34 PF09443 CFC Pfam 9.605E-4 1.130E-3 4.835E-3 3.842E-2 1 3
35 PS01208 VWFC 1 PROSITE 1.148E-2 1.311E-2
5.611E-2
4.590E-1
 1 36
36 PS50184 VWFC 2 PROSITE 1.211E-2 1.346E-2
5.757E-2
4.844E-1
 1 38
37 IPR001878 Znf CCHC InterPro 1.749E-2 1.841E-2
7.876E-2
6.995E-1
 1 55
38 SM00343 ZnF C2HC SMART 1.749E-2 1.841E-2
7.876E-2
6.995E-1
 1 55
39 IPR009079 4 helix cytokine-like core InterPro 2.347E-2 2.407E-2
1.030E-1
9.388E-1
 1 74
Show 34 more annotations

7: Pathway [Display Chart] 6 input genes in category / 50 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1268884 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant BioSystems: REACTOME 2.175E-9 5.438E-8 2.447E-7 1.088E-7 3 7
2 1268885 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant BioSystems: REACTOME 2.175E-9 5.438E-8 2.447E-7 1.088E-7 3 7
3 1269542 Signaling by NOTCH4 BioSystems: REACTOME 1.025E-8 1.281E-7 5.763E-7 5.124E-7 3 11
4 1269541 Signaling by NOTCH3 BioSystems: REACTOME 1.025E-8 1.281E-7 5.763E-7 5.124E-7 3 11
5 1268886 Signaling by NOTCH1 HD Domain Mutants in Cancer BioSystems: REACTOME 2.824E-8 2.353E-7 1.059E-6 1.412E-6 3 15
6 1268887 Constitutive Signaling by NOTCH1 HD Domain Mutants BioSystems: REACTOME 2.824E-8 2.353E-7 1.059E-6 1.412E-6 3 15
7 1269539 NOTCH2 Activation and Transmission of Signal to the Nucleus BioSystems: REACTOME 8.245E-8 5.890E-7 2.650E-6 4.123E-6 3 21
8 1269536 Activated NOTCH1 Transmits Signal to the Nucleus BioSystems: REACTOME 2.782E-7 1.739E-6 7.822E-6 1.391E-5 3 31
9 1269538 Signaling by NOTCH2 BioSystems: REACTOME 3.375E-7 1.875E-6 8.436E-6 1.688E-5 3 33
10 PW:0000204 Notch signaling Pathway Ontology 4.047E-7 2.024E-6 9.105E-6 2.024E-5 3 35
11 83062 Notch signaling pathway BioSystems: KEGG 1.067E-6 4.850E-6 2.182E-5 5.335E-5 3 48
12 1268889 Constitutive Signaling by NOTCH1 PEST Domain Mutants BioSystems: REACTOME 1.900E-6 5.589E-6 2.514E-5 9.501E-5 3 58
13 1268891 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants BioSystems: REACTOME 1.900E-6 5.589E-6 2.514E-5 9.501E-5 3 58
14 1268890 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer BioSystems: REACTOME 1.900E-6 5.589E-6 2.514E-5 9.501E-5 3 58
15 1268888 Signaling by NOTCH1 PEST Domain Mutants in Cancer BioSystems: REACTOME 1.900E-6 5.589E-6 2.514E-5 9.501E-5 3 58
16 169345 Notch signaling pathway BioSystems: Pathway Interaction Database 1.900E-6 5.589E-6 2.514E-5 9.501E-5 3 58
17 1268883 Signaling by NOTCH1 in Cancer BioSystems: REACTOME 1.900E-6 5.589E-6 2.514E-5 9.501E-5 3 58
18 1269535 Signaling by NOTCH1 BioSystems: REACTOME 3.980E-6 1.106E-5 4.975E-5 1.990E-4 3 74
19 PW:0000324 altered Notch signaling Pathway Ontology 5.413E-6 1.424E-5 6.409E-5 2.706E-4 2 8
20 1458885 Th1 and Th2 cell differentiation BioSystems: KEGG 7.686E-6 1.921E-5 8.645E-5 3.843E-4 3 92
21 1404799 Endocrine resistance BioSystems: KEGG 8.738E-6 2.081E-5 9.361E-5 4.369E-4 3 96
22 1269530 Signaling by NOTCH BioSystems: REACTOME 1.428E-5 3.244E-5 1.460E-4 7.138E-4 3 113
23 1435207 Breast cancer BioSystems: KEGG 2.955E-5 6.423E-5 2.890E-4 1.477E-3 3 144
24 P00005 Angiogenesis PantherDB 3.339E-5 6.956E-5 3.129E-4 1.669E-3 3 150
25 P00045 Notch signaling pathway PantherDB 1.279E-4 2.559E-4 1.151E-3 6.397E-3 2 37
26 PW:0000349 Alagille syndrome Pathway Ontology 4.819E-4 9.237E-4 4.156E-3 2.410E-2 1 1
27 1268855 Diseases of signal transduction BioSystems: REACTOME 4.988E-4 9.237E-4 4.156E-3 2.494E-2 3 373
28 812256 TNF signaling pathway BioSystems: KEGG 1.093E-3 1.952E-3 8.783E-3
5.466E-2
 2 108
29 1492886 Apelin signaling pathway BioSystems: KEGG 1.777E-3 3.064E-3 1.379E-2
8.885E-2
 2 138
30 PW:0000340 altered Notch signaling involving the main players Pathway Ontology 1.927E-3 3.211E-3 1.445E-2
9.633E-2
 1 4
31 M16173 Presenilin action in Notch and Wnt signaling MSigDB C2 BIOCARTA (v6.0) 6.729E-3 1.085E-2 4.883E-2
3.365E-1
 1 14
32 M5298 Regulation of hematopoiesis by cytokines MSigDB C2 BIOCARTA (v6.0) 7.209E-3 1.092E-2 4.914E-2
3.604E-1
 1 15
33 M11736 Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. MSigDB C2 BIOCARTA (v6.0) 7.209E-3 1.092E-2 4.914E-2
3.604E-1
 1 15
34 M14449 METS affect on Macrophage Differentiation MSigDB C2 BIOCARTA (v6.0) 8.645E-3 1.271E-2
5.720E-2
4.323E-1
 1 18
35 M5883 Genes encoding secreted soluble factors MSigDB C2 BIOCARTA (v6.0) 1.061E-2 1.515E-2
6.818E-2
5.304E-1
 2 344
36 M8809 Phosphoinositides and their downstream targets. MSigDB C2 BIOCARTA (v6.0) 1.104E-2 1.533E-2
6.896E-2
5.518E-1
 1 23
37 M6910 Cytokines and Inflammatory Response MSigDB C2 BIOCARTA (v6.0) 1.390E-2 1.878E-2
8.450E-2
6.949E-1
 1 29
38 169350 Signaling events mediated by TCPTP BioSystems: Pathway Interaction Database 1.723E-2 2.267E-2
1.020E-1
8.614E-1
 1 36
39 137914 Presenilin action in Notch and Wnt signaling BioSystems: Pathway Interaction Database 2.197E-2 2.746E-2
1.236E-1
1.000E0
 1 46
40 137999 Integrins in angiogenesis BioSystems: Pathway Interaction Database 2.197E-2 2.746E-2
1.236E-1
1.000E0
 1 46
41 1470924 Interleukin-10 signaling BioSystems: REACTOME 2.339E-2 2.841E-2
1.278E-1
1.000E0
 1 49
42 138017 Signaling events mediated by PTP1B BioSystems: Pathway Interaction Database 2.386E-2 2.841E-2
1.278E-1
1.000E0
 1 50
43 169353 Validated targets of C-MYC transcriptional repression BioSystems: Pathway Interaction Database 2.905E-2 3.377E-2
1.520E-1
1.000E0
 1 61
44 200309 Rheumatoid arthritis BioSystems: KEGG 4.261E-2 4.842E-2
2.178E-1
1.000E0
 1 90
Show 39 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 2040 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9716576 Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells. Pubmed 2.154E-12 4.394E-9 3.603E-8 4.394E-9 3 3
2 9858728 The Notch signalling pathway in hair growth. Pubmed 8.616E-12 5.859E-9 4.803E-8 1.758E-8 3 4
3 20602435 Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate. Pubmed 8.616E-12 5.859E-9 4.803E-8 1.758E-8 3 4
4 15788413 The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface. Pubmed 2.154E-11 6.277E-9 5.146E-8 4.394E-8 3 5
5 21602525 Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells. Pubmed 2.154E-11 6.277E-9 5.146E-8 4.394E-8 3 5
6 12175503 Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain. Pubmed 2.154E-11 6.277E-9 5.146E-8 4.394E-8 3 5
7 11006133 Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. Pubmed 2.154E-11 6.277E-9 5.146E-8 4.394E-8 3 5
8 27510977 Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling. Pubmed 3.013E-11 7.683E-9 6.298E-8 6.146E-8 4 47
9 10958687 Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Pubmed 4.307E-11 9.763E-9 8.004E-8 8.787E-8 3 6
10 10079256 Human ligands of the Notch receptor. Pubmed 7.538E-11 1.398E-8 1.146E-7 1.538E-7 3 7
11 12846471 The distribution of Notch receptors and their ligands during articular cartilage development. Pubmed 7.538E-11 1.398E-8 1.146E-7 1.538E-7 3 7
12 9858718 Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear. Pubmed 1.206E-10 1.892E-8 1.551E-7 2.460E-7 3 8
13 11044610 Notch/Delta expression in the developing mouse lung. Pubmed 1.206E-10 1.892E-8 1.551E-7 2.460E-7 3 8
14 11118901 Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system. Pubmed 1.809E-10 2.306E-8 1.891E-7 3.690E-7 3 9
15 10837027 Notch signaling is essential for vascular morphogenesis in mice. Pubmed 1.809E-10 2.306E-8 1.891E-7 3.690E-7 3 9
16 16245338 Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud. Pubmed 1.809E-10 2.306E-8 1.891E-7 3.690E-7 3 9
17 23665443 Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta. Pubmed 2.584E-10 3.101E-8 2.542E-7 5.271E-7 3 10
18 17823936 Dll3 is expressed in developing hair cells in the mammalian cochlea. Pubmed 3.553E-10 3.451E-8 2.829E-7 7.247E-7 3 11
19 10842072 Notch gene expression during pancreatic organogenesis. Pubmed 3.553E-10 3.451E-8 2.829E-7 7.247E-7 3 11
20 12866128 Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions. Pubmed 3.553E-10 3.451E-8 2.829E-7 7.247E-7 3 11
21 10878608 Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators. Pubmed 3.553E-10 3.451E-8 2.829E-7 7.247E-7 3 11
22 11807030 Notch1 is required for neuronal and glial differentiation in the cerebellum. Pubmed 4.736E-10 4.201E-8 3.444E-7 9.662E-7 3 12
23 15465494 Developmental expression of the Notch signaling pathway genes during mouse preimplantation development. Pubmed 4.736E-10 4.201E-8 3.444E-7 9.662E-7 3 12
24 11578869 Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Pubmed 6.157E-10 4.831E-8 3.960E-7 1.256E-6 3 13
25 11171333 Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Pubmed 6.157E-10 4.831E-8 3.960E-7 1.256E-6 3 13
26 11934853 Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage. Pubmed 6.157E-10 4.831E-8 3.960E-7 1.256E-6 3 13
27 14757642 Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. Pubmed 7.836E-10 5.709E-8 4.680E-7 1.599E-6 3 14
28 18505817 Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches. Pubmed 7.836E-10 5.709E-8 4.680E-7 1.599E-6 3 14
29 12167404 Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth. Pubmed 9.794E-10 6.055E-8 4.964E-7 1.998E-6 3 15
30 17273555 An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. Pubmed 9.794E-10 6.055E-8 4.964E-7 1.998E-6 3 15
31 12971992 Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development. Pubmed 9.794E-10 6.055E-8 4.964E-7 1.998E-6 3 15
32 16914494 COUP-TFI controls Notch regulation of hair cell and support cell differentiation. Pubmed 9.794E-10 6.055E-8 4.964E-7 1.998E-6 3 15
33 16324690 BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Pubmed 9.794E-10 6.055E-8 4.964E-7 1.998E-6 3 15
34 12617809 Expression of Notch pathway components in fetal and adult mouse small intestine. Pubmed 1.205E-9 6.830E-8 5.600E-7 2.459E-6 3 16
35 14651921 FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Pubmed 1.205E-9 6.830E-8 5.600E-7 2.459E-6 3 16
36 22464328 Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments. Pubmed 1.205E-9 6.830E-8 5.600E-7 2.459E-6 3 16
37 15242798 The role of Pax2 in mouse inner ear development. Pubmed 1.464E-9 7.464E-8 6.119E-7 2.986E-6 3 17
38 19501159 Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Pubmed 1.464E-9 7.464E-8 6.119E-7 2.986E-6 3 17
39 18694942 Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. Pubmed 1.464E-9 7.464E-8 6.119E-7 2.986E-6 3 17
40 15821257 Segmental expression of Notch and Hairy genes in nephrogenesis. Pubmed 1.464E-9 7.464E-8 6.119E-7 2.986E-6 3 17
41 15689374 RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Pubmed 1.756E-9 8.332E-8 6.830E-7 3.583E-6 3 18
42 18093989 Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling. Pubmed 1.756E-9 8.332E-8 6.830E-7 3.583E-6 3 18
43 16518823 Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium. Pubmed 1.756E-9 8.332E-8 6.830E-7 3.583E-6 3 18
44 28656980 Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Pubmed 2.085E-9 9.668E-8 7.926E-7 4.254E-6 3 19
45 29961574 Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels. Pubmed 2.453E-9 1.088E-7 8.919E-7 5.005E-6 3 20
46 19686682 The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. Pubmed 2.453E-9 1.088E-7 8.919E-7 5.005E-6 3 20
47 17625108 Mesenchymal cells are required for functional development of thymic epithelial cells. Pubmed 2.862E-9 1.216E-7 9.972E-7 5.838E-6 3 21
48 21750033 Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme. Pubmed 2.862E-9 1.216E-7 9.972E-7 5.838E-6 3 21
49 23362349 Hepatocyte nuclear factor 1β controls nephron tubular development. Pubmed 3.810E-9 1.495E-7 1.226E-6 7.773E-6 3 23
50 14701881 Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Pubmed 3.810E-9 1.495E-7 1.226E-6 7.773E-6 3 23
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 71 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MFAP5 MFAP5 interactions 1.784E-9 1.266E-7 6.138E-7 1.266E-7 3 11
2 int:NOTCH2 NOTCH2 interactions 4.700E-7 9.059E-6 4.391E-5 3.337E-5 3 65
3 int:MIB1 MIB1 interactions 5.887E-7 9.059E-6 4.391E-5 4.180E-5 3 70
4 int:NOTCH3 NOTCH3 interactions 6.147E-7 9.059E-6 4.391E-5 4.364E-5 3 71
5 int:MFNG MFNG interactions 6.380E-7 9.059E-6 4.391E-5 4.530E-5 2 5
6 int:MFAP2 MFAP2 interactions 2.296E-6 2.717E-5 1.317E-4 1.630E-4 2 9
7 int:NEURL1 NEURL1 interactions 3.507E-6 3.557E-5 1.724E-4 2.490E-4 2 11
8 int:POFUT1 POFUT1 interactions 5.800E-6 5.147E-5 2.495E-4 4.118E-4 2 14
9 int:NOTCH1 NOTCH1 interactions 2.473E-5 1.951E-4 9.454E-4 1.755E-3 3 242
10 int:NEURL2 NEURL2 interactions 1.976E-3 1.403E-2
6.799E-2
1.403E-1
 1 7
11 int:SLA2 SLA2 interactions 2.540E-3 1.639E-2
7.945E-2
1.803E-1
 1 9
12 int:GAB3 GAB3 interactions 2.822E-3 1.669E-2
8.091E-2
2.003E-1
 1 10
13 int:PLPPR1 PLPPR1 interactions 3.667E-3 1.860E-2
9.013E-2
2.603E-1
 1 13
14 int:CSF1 CSF1 interactions 3.667E-3 1.860E-2
9.013E-2
2.603E-1
 1 13
15 int:CNKSR3 CNKSR3 interactions 3.948E-3 1.869E-2
9.058E-2
2.803E-1
 1 14
16 int:GFI1 GFI1 interactions 4.793E-3 1.906E-2
9.237E-2
3.403E-1
 1 17
17 int:JAG1 JAG1 interactions 4.793E-3 1.906E-2
9.237E-2
3.403E-1
 1 17
18 int:CCN3 CCN3 interactions 5.355E-3 1.906E-2
9.237E-2
3.802E-1
 1 19
19 int:DLL1 DLL1 interactions 5.637E-3 1.906E-2
9.237E-2
4.002E-1
 1 20
20 int:MAGI2 MAGI2 interactions 5.637E-3 1.906E-2
9.237E-2
4.002E-1
 1 20
21 int:UST UST interactions 5.637E-3 1.906E-2
9.237E-2
4.002E-1
 1 20
22 int:STS STS interactions 6.199E-3 2.000E-2
9.694E-2
4.401E-1
 1 22
23 int:ADAM32 ADAM32 interactions 6.480E-3 2.000E-2
9.694E-2
4.601E-1
 1 23
24 int:JAG2 JAG2 interactions 6.761E-3 2.000E-2
9.694E-2
4.800E-1
 1 24
25 int:MIB2 MIB2 interactions 8.165E-3 2.295E-2
1.112E-1
5.797E-1
 1 29
26 int:MAGI3 MAGI3 interactions 8.445E-3 2.295E-2
1.112E-1
5.996E-1
 1 30
27 int:ADAM10 ADAM10 interactions 8.726E-3 2.295E-2
1.112E-1
6.195E-1
 1 31
28 int:ATP1B4 ATP1B4 interactions 1.097E-2 2.704E-2
1.311E-1
7.787E-1
 1 39
29 int:CSF1R CSF1R interactions 1.125E-2 2.704E-2
1.311E-1
7.986E-1
 1 40
30 int:PRDM5 PRDM5 interactions 1.153E-2 2.704E-2
1.311E-1
8.185E-1
 1 41
31 int:ZBTB17 ZBTB17 interactions 1.181E-2 2.704E-2
1.311E-1
8.383E-1
 1 42
32 int:MPDZ MPDZ interactions 1.237E-2 2.744E-2
1.330E-1
8.781E-1
 1 44
33 int:THBS1 THBS1 interactions 1.516E-2 3.262E-2
1.581E-1
1.000E0
 1 54
34 int:SPI1 SPI1 interactions 1.655E-2 3.457E-2
1.676E-1
1.000E0
 1 59
35 int:PIAS3 PIAS3 interactions 1.823E-2 3.673E-2
1.780E-1
1.000E0
 1 65
36 int:RUNX1T1 RUNX1T1 interactions 1.934E-2 3.673E-2
1.780E-1
1.000E0
 1 69
37 int:EPN1 EPN1 interactions 1.962E-2 3.673E-2
1.780E-1
1.000E0
 1 70
38 int:ARIH2 ARIH2 interactions 1.990E-2 3.673E-2
1.780E-1
1.000E0
 1 71
39 int:VASN VASN interactions 2.017E-2 3.673E-2
1.780E-1
1.000E0
 1 72
40 int:TMEM30B TMEM30B interactions 2.212E-2 3.835E-2
1.859E-1
1.000E0
 1 79
41 int:SOCS1 SOCS1 interactions 2.295E-2 3.835E-2
1.859E-1
1.000E0
 1 82
42 int:PICK1 PICK1 interactions 2.323E-2 3.835E-2
1.859E-1
1.000E0
 1 83
43 int:ATXN7 ATXN7 interactions 2.323E-2 3.835E-2
1.859E-1
1.000E0
 1 83
44 int:HLA-B HLA-B interactions 2.406E-2 3.882E-2
1.882E-1
1.000E0
 1 86
45 int:RCOR1 RCOR1 interactions 2.710E-2 4.226E-2
2.048E-1
1.000E0
 1 97
46 int:APBB1 APBB1 interactions 2.738E-2 4.226E-2
2.048E-1
1.000E0
 1 98
47 int:MAGI1 MAGI1 interactions 2.931E-2 4.247E-2
2.058E-1
1.000E0
 1 105
48 int:ATN1 ATN1 interactions 2.931E-2 4.247E-2
2.058E-1
1.000E0
 1 105
49 int:CACNA1A CACNA1A interactions 2.931E-2 4.247E-2
2.058E-1
1.000E0
 1 105
50 int:GFI1B GFI1B interactions 3.206E-2 4.491E-2
2.177E-1
1.000E0
 1 115
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20p12.1-p11.23 20p12.1-p11.23 3.462E-4 2.077E-3 5.089E-3 2.077E-3 1 2
2 1p22 1p22 3.457E-3 1.037E-2 2.541E-2 2.074E-2 1 20
3 6q27 6q27 1.034E-2 1.206E-2 2.954E-2
6.205E-2
 1 60
4 14q32 14q32 1.034E-2 1.206E-2 2.954E-2
6.205E-2
 1 60
5 2q21.1 2q21.1 1.086E-2 1.206E-2 2.954E-2
6.514E-2
 1 63
6 1p13.3 1p13.3 1.206E-2 1.206E-2 2.954E-2
7.234E-2
 1 70
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 75 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 2 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1259 SNAG transcriptional repressors genenames.org 1.099E-3 2.198E-3 3.297E-3 2.198E-3 1 10
2 471 CD molecules|Tumor necrosis factor superfamily genenames.org 4.284E-2 4.284E-2
6.426E-2
8.569E-2
 1 394

13: Coexpression [Display Chart] 6 input genes in category / 868 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17823238-TableS4a Mouse EmbryonicStemCell Soh07 224genes A GeneSigDB 3.669E-10 1.919E-7 1.410E-6 3.185E-7 5 212
2 17823238-TableS4b Human EmbryonicStemCell Soh07 224genes B GeneSigDB 4.422E-10 1.919E-7 1.410E-6 3.839E-7 5 220
3 M2207 Genes up-regulated in RAW 264.7 cells (macrophage) upon stimulation with TNFSF11 [GeneID=8600]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.419E-9 1.568E-6 1.152E-5 4.704E-6 3 16
4 17823238-TableS7a Human EmbryonicStemCell Soh07 27genes A GeneSigDB 1.489E-8 3.232E-6 2.374E-5 1.293E-5 3 22
5 M5895 Genes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1 [GeneID=1499]. MSigDB H: Hallmark Gene Sets (v6.0) 1.108E-7 1.924E-5 1.413E-4 9.619E-5 3 42
6 20220088-SuppTable2a Human Immune Allen10 106genes GeneSigDB 1.697E-6 2.455E-4 1.803E-3 1.473E-3 3 103
7 M17374 Genes up-regulated in DLD1 cells (colon cancer) by p73 beta [GeneID=7161] or by and p63 gamma [GeneID=8626] but not by p53 [GeneID=7157]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.079E-6 3.818E-4 2.804E-3 2.673E-3 2 11
8 M12112 Angiogenic markers up-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.012E-6 7.608E-4 5.587E-3 6.086E-3 3 165
9 M4125 Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus those stimulated with CpG DNA (TLR9 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 1.084E-3 7.958E-3 1.084E-2 3 200
10 M3164 Genes up-regulated in comparison of Th2 cells versus Th17 cells. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 1.084E-3 7.958E-3 1.084E-2 3 200
11 M9946 Up-regulated genes of putative pathways stimulated in tumor endothelial cells by papillary serous ovarian epithelial tumor cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.677E-5 1.323E-3 9.717E-3 1.456E-2 2 25
12 M5903 Genes up-regulated by activation of Notch signaling. MSigDB H: Hallmark Gene Sets (v6.0) 2.770E-5 2.004E-3 1.472E-2 2.405E-2 2 32
13 M5944 Genes up-regulated during formation of blood vessels (angiogenesis). MSigDB H: Hallmark Gene Sets (v6.0) 3.517E-5 2.348E-3 1.725E-2 3.053E-2 2 36
14 M8556 Genes up-regulated in A549 cells (lung cancer) upon expression of ASCL1 [GeneID=429] off a viral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.771E-5 3.578E-3 2.628E-2
5.009E-2
 2 46
15 20460173-ImmPortCytokines Human Immune Kong10 456genes ImmPort Cytokines GeneSigDB 1.248E-4 7.224E-3
5.305E-2
1.084E-1
 3 433
16 17638894-Table2 Mouse Breast Piechocki07 87genes GefitinibSensitiveResistant GeneSigDB 1.584E-4 8.591E-3
6.310E-2
1.375E-1
 2 76
17 17178894-Table1 Human Breast Fan06 104genes GeneSigDB 2.910E-4 1.458E-2
1.071E-1
2.526E-1
 2 103
18 M12602 Genes positively correlated with recurrence free survival in patients with hepatitis B-related (HBV) hepatocellular carcinoma (HCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 3.024E-4 1.458E-2
1.071E-1
2.625E-1
 2 105
19 12509443-Table1 Human ProteinKinases Frevel03 112genes GeneSigDB 3.318E-4 1.516E-2
1.113E-1
2.880E-1
 2 110
20 12747878-Table3 Human Breast Huang03 164genes recurrence GeneSigDB 5.291E-4 2.053E-2
1.508E-1
4.592E-1
 2 139
21 20067540-Table3 Human UmbilicalCordBloodCells Miyagawa09 145genes GeneSigDB 5.367E-4 2.053E-2
1.508E-1
4.658E-1
 2 140
22 M2784 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of PCGF2 [Gene ID=7703] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 5.443E-4 2.053E-2
1.508E-1
4.725E-1
 2 141
23 M2779 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 and PCGF2 [Gene ID=648, 7703] genes by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 5.755E-4 2.053E-2
1.508E-1
4.995E-1
 2 145
24 M2534 The '3/3 signature': genes consistently up-regulated in all three pools of normal mammary stem cells (defined by their ability to retain the dye PKH26). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.834E-4 2.053E-2
1.508E-1
5.064E-1
 2 146
25 M2782 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 [Gene ID=648] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 5.914E-4 2.053E-2
1.508E-1
5.134E-1
 2 147
26 M2526 Genes representing a co-expression network in atopic CD4 [GeneID=920] T lymphocyte responses. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.239E-4 2.057E-2
1.511E-1
5.415E-1
 2 151
27 M2038 Genes up-regulated in APL (acute promyeolocytic leukemia) blasts expressing PML-RARA fusion [GeneID=5371;5914] compared to normal promyeloblasts. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.555E-4 2.057E-2
1.511E-1
7.426E-1
 2 177
28 M2816 Genes up-regulated in CD34+ hematopoietic progenitor cells after knockdown of RPS14 [Gene ID=6208] by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 1.005E-3 2.057E-2
1.511E-1
8.726E-1
 2 192
29 M7463 Genes down-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: medium versus TGF beta. MSigDB C7: Immunologic Signatures (v6.0) 1.058E-3 2.057E-2
1.511E-1
9.182E-1
 2 197
30 M4959 Genes down-regulated in comparison of B cells from influenza vaccinee at day 7 post-vaccination versus plasmacytoid dendritic cells (pDC) at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.057E-2
1.511E-1
9.368E-1
 2 199
31 M5491 Genes up-regulated in comparison of macrophages versus neutrophils. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.057E-2
1.511E-1
9.368E-1
 2 199
32 M4005 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.057E-2
1.511E-1
9.368E-1
 2 199
33 M8401 Genes up-regulated in brain microglia versus bone marrow monocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.057E-2
1.511E-1
9.368E-1
 2 199
34 M5508 Genes up-regulated in comparison of macrophages versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
35 M8564 Genes up-regulated in T helper cells 5 days post polarization: Th1 versus Th17. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
36 M9685 Genes down-regulated in CD4 [GeneID=920] T helper cells Th17 treated with TGFB1 and IL6 [GeneID=7040;3569]: 1h versus 60h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
37 M5045 Genes down-regulated in comparison of splenic primary CD8 effector T cells at day 8 post-chronic infection versus splenic secondary CD8 effector T cells at day 8 post-chronic infection. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
38 M3814 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
39 M8554 Genes up-regulated in CD8 T cells: KLRB1 int [GeneID=3820] versus KLRB1- [GeneID=3820]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
40 M5890 Genes regulated by NF-kB in response to TNF [GeneID=7124]. MSigDB H: Hallmark Gene Sets (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
41 M9652 Genes up-regulated in CD4 [GeneID=920] T helper cells (52h): Th0 versus Th17 treated with TGFB1, IL6 [GeneID=7040;3569] and IL-23. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
42 M3939 Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 2 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
43 M8654 Genes down-regulated in P14 CD8+ T cells: ST2 [GeneID=6761] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
44 M3676 Genes down-regulated in comparison of T effector cells from uninfected mice versus T effector cells from mice infected with S. mansoni. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
45 M3452 Genes up-regulated in comparison of CD4 [GeneID=920] CD8 thymocytes versus T cells from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
46 M6836 Genes up-regulated in CD4 [GeneID=920] T cells from lymph nodes: naïve versus day 7 after immunization. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.057E-2
1.511E-1
9.462E-1
 2 200
47 M5793 Down-regulated genes in the canonical gene expression signature of the fibroblast core serum response (CSR) defined by the Stanford group. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.189E-3 2.197E-2
1.613E-1
1.000E0
 2 209
48 19235837-Table2 Human Pancreas Cavard09 7genes GeneSigDB 1.814E-3 3.214E-2
2.360E-1
1.000E0
 1 7
49 M18597 Genes up-regulated in SaOS-2 cells (osteosarcoma) upon expression of PAX3-FOXO1 [GeneID=5077;2308] but down-regulated by PAX3 expression off adenoviral vectors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.814E-3 3.214E-2
2.360E-1
1.000E0
 1 7
50 16135788-Table13 Human Breast Wang05 410genes up BT-BAF57cells GeneSigDB 1.973E-3 3.425E-2
2.516E-1
1.000E0
 2 270
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 533 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingKidney e14.5 whole kidney - wildtype 100 k5 DevelopingKidney e14.5 whole kidney - wildtype emap-6674 k-means-cluster#5 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.074E-5 5.727E-3 3.927E-2 5.727E-3 2 19
2 gudmap developingKidney e14.5 whole kidney - wildtype 200 k3 DevelopingKidney e14.5 whole kidney - wildtype emap-6674 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.111E-5 8.292E-3
5.686E-2
 1.658E-2 2 32
3 gudmap developingKidney e12.5 renal vesicle 200 k2 DevelopingKidney e12.5 renal vesicle emap-27679 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 8.298E-5 1.474E-2
1.011E-1
 4.423E-2 2 52
4 gudmap developingKidney e15.5 S-shaped body 500 k1 DevelopingKidney e15.5 S-shaped body emap-27855 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.686E-4 1.664E-2
1.141E-1
8.985E-2
 2 74
5 gudmap developingKidney e14.5 whole kidney - wildtype emap-6674 100 DevelopingKidney e14.5 whole kidney - wildtype emap-6674 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.873E-4 1.664E-2
1.141E-1
9.984E-2
 2 78
6 gudmap developingKidney e15.5 Proximal Tubules 1000 k2 DevelopingKidney e15.5 Proximal Tubules emap-28005 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.873E-4 1.664E-2
1.141E-1
9.984E-2
 2 78
7 Sample Type by Project: Shred 1/TCGA-Adrenal Cortex/Adrenocortical carcinoma/Usual Type/2/4 Sample Type by Project: Shred 1/TCGA-Adrenal Cortex/Adrenocortical carcinoma/Usual Type/2/4 TCGA-Adrenal Cortex 2.749E-4 2.093E-2
1.435E-1
1.465E-1
 1 1
8 gudmap developingKidney e14.5 whole kidney - wildtype 500 k5 DevelopingKidney e14.5 whole kidney - wildtype emap-6674 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.395E-4 2.262E-2
1.551E-1
1.809E-1
 2 105
9 gudmap developingKidney e15.5 1000 k2 DevelopingKidney e15.5 anlage of loop of Henle emap-31283 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.197E-4 3.003E-2
2.059E-1
2.770E-1
 2 130
10 gudmap developingKidney e12.5 renal vesicle 500 k2 DevelopingKidney e12.5 renal vesicle emap-27679 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.728E-4 3.003E-2
2.059E-1
3.586E-1
 2 148
11 gudmap developingKidney e14.5 whole kidney - wildtype emap-6674 200 DevelopingKidney e14.5 whole kidney - wildtype emap-6674 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 7.002E-4 3.003E-2
2.059E-1
3.732E-1
 2 151
12 Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma Heterologous Type/3/3 Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma Heterologous Type/3/3 TCGA-Uterus 7.565E-4 3.003E-2
2.059E-1
4.032E-1
 2 157
13 gudmap developingKidney e14.5 whole kidney - wildtype 1000 k4 DevelopingKidney e14.5 whole kidney - wildtype emap-6674 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.661E-4 3.003E-2
2.059E-1
4.084E-1
 2 158
14 gudmap developingKidney e12.5 renal vesicle 200 DevelopingKidney e12.5 renal vesicle emap-27679 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 7.953E-4 3.003E-2
2.059E-1
4.239E-1
 2 161
15 gudmap kidney P4 CapMesRenVes Crym k3 500 kidney P4 CapMesRenVes Crym k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.451E-4 3.003E-2
2.059E-1
4.505E-1
 2 166
16 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Tongue/basal cell of epidermis Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Tongue/basal cell of epidermis Tabula Muris Consortium 1.093E-3 3.254E-2
2.231E-1
5.827E-1
 2 189
17 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Mammary Gland Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Mammary Gland Tabula Muris Consortium 1.093E-3 3.254E-2
2.231E-1
5.827E-1
 2 189
18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal RCC U U/Kidney Normal RCC U18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal RCC U U/Kidney Normal RCC U18 Adult, Development, and Cancer types 1.099E-3 3.254E-2
2.231E-1
5.858E-1
 1 4
19 gudmap developingKidney e15.5 S-shaped body 1000 k1 DevelopingKidney e15.5 S-shaped body emap-27855 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.372E-3 3.850E-2
2.640E-1
7.315E-1
 2 212
Show 14 more annotations

15: Computational [Display Chart] 5 input genes in category / 44 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M7888 MODULE 433 Cytokines and GFs. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.591E-4 1.580E-2
6.909E-2
 1.580E-2 2 61
2 M12600 MODULE 195 Breast cancer expression clusters. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.070E-3 3.159E-2
1.381E-1
9.107E-2
 2 147
3 M16406 MODULE 356 Genes in the cancer module 356. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.154E-3 3.159E-2
1.381E-1
9.478E-2
 2 150

16: MicroRNA [Display Chart] 6 input genes in category / 230 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ACTGCCT,MIR-34B:MSigDB ACTGCCT,MIR-34B:MSigDB MSigDB 1.193E-4 5.672E-3 3.413E-2 2.744E-2 2 205
2 hsa-miR-214-3p:Functional MTI Functional MTI miRTarbase 1.205E-4 5.672E-3 3.413E-2 2.771E-2 2 206
3 hsa-miR-410-3p:Functional MTI Functional MTI miRTarbase 1.773E-4 5.672E-3 3.413E-2 4.078E-2 2 250
4 CACTGCC,MIR-34C:MSigDB CACTGCC,MIR-34C:MSigDB MSigDB 2.021E-4 5.672E-3 3.413E-2 4.649E-2 2 267
5 CACTGCC,MIR-34A:MSigDB CACTGCC,MIR-34A:MSigDB MSigDB 2.021E-4 5.672E-3 3.413E-2 4.649E-2 2 267
6 CACTGCC,MIR-449:MSigDB CACTGCC,MIR-449:MSigDB MSigDB 2.021E-4 5.672E-3 3.413E-2 4.649E-2 2 267
7 hsa-miR-34a:PITA hsa-miR-34a:PITA TOP PITA 2.466E-4 5.672E-3 3.413E-2
5.672E-2
 2 295
8 hsa-miR-449a:PITA hsa-miR-449a:PITA TOP PITA 2.466E-4 5.672E-3 3.413E-2
5.672E-2
 2 295
9 hsa-miR-34c-5p:PITA hsa-miR-34c-5p:PITA TOP PITA 2.466E-4 5.672E-3 3.413E-2
5.672E-2
 2 295
10 hsa-miR-449b:PITA hsa-miR-449b:PITA TOP PITA 2.466E-4 5.672E-3 3.413E-2
5.672E-2
 2 295
11 hsa-miR-499-3p:PITA hsa-miR-499-3p:PITA TOP PITA 3.368E-4 6.064E-3 3.649E-2
7.747E-2
 2 345
12 hsa-miR-1280:mirSVR lowEffct hsa-miR-1280:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.913E-4 6.064E-3 3.649E-2
9.000E-2
 2 372
13 TTGCACT,MIR-301:MSigDB TTGCACT,MIR-301:MSigDB MSigDB 3.955E-4 6.064E-3 3.649E-2
9.096E-2
 2 374
14 TTGCACT,MIR-130B:MSigDB TTGCACT,MIR-130B:MSigDB MSigDB 3.955E-4 6.064E-3 3.649E-2
9.096E-2
 2 374
15 TTGCACT,MIR-130A:MSigDB TTGCACT,MIR-130A:MSigDB MSigDB 3.955E-4 6.064E-3 3.649E-2
9.096E-2
 2 374
16 hsa-miR-214*:mirSVR highEffct hsa-miR-214*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.298E-4 6.179E-3 3.718E-2
9.887E-2
 2 390
17 hsa-miR-377-3p:TargetScan hsa-miR-377-3p TargetScan 6.306E-4 7.560E-3 4.549E-2
1.450E-1
 2 473
18 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 6.574E-4 7.560E-3 4.549E-2
1.512E-1
 2 483
19 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 6.574E-4 7.560E-3 4.549E-2
1.512E-1
 2 483
20 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 6.574E-4 7.560E-3 4.549E-2
1.512E-1
 2 483
21 hsa-miR-423-3p:PITA hsa-miR-423-3p:PITA TOP PITA 1.992E-3 2.181E-2
1.313E-1
4.581E-1
 1 24
22 hsa-miR-1277:PITA hsa-miR-1277:PITA TOP PITA 2.489E-3 2.602E-2
1.566E-1
5.725E-1
 1 30
23 hsa-miR-598:PITA hsa-miR-598:PITA TOP PITA 4.063E-3 3.546E-2
2.134E-1
9.345E-1
 1 49
24 hsa-miR-5580-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.228E-3 3.546E-2
2.134E-1
9.726E-1
 1 51
25 hsa-miR-8083:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.394E-3 3.546E-2
2.134E-1
1.000E0
 1 53
26 hsa-miR-184:Functional MTI Functional MTI miRTarbase 4.560E-3 3.546E-2
2.134E-1
1.000E0
 1 55
27 CAAGGAT,MIR-362:MSigDB CAAGGAT,MIR-362:MSigDB MSigDB 4.808E-3 3.546E-2
2.134E-1
1.000E0
 1 58
28 hsa-miR-615-3p:mirSVR highEffct hsa-miR-615-3p:mirSVR conserved highEffect-0.5 MicroRNA.org 6.048E-3 3.546E-2
2.134E-1
1.000E0
 1 73
29 AGGCACT,MIR-515-3P:MSigDB AGGCACT,MIR-515-3P:MSigDB MSigDB 7.039E-3 3.546E-2
2.134E-1
1.000E0
 1 85
30 AGCTCCT,MIR-28:MSigDB AGCTCCT,MIR-28:MSigDB MSigDB 7.369E-3 3.546E-2
2.134E-1
1.000E0
 1 89
31 hsa-miR-624-3p:Functional MTI Functional MTI miRTarbase 8.360E-3 3.546E-2
2.134E-1
1.000E0
 1 101
32 hsa-let-7c-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.360E-3 3.546E-2
2.134E-1
1.000E0
 1 101
33 hsa-let-7a-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.442E-3 3.546E-2
2.134E-1
1.000E0
 1 102
34 hsa-miR-509-3p:PITA hsa-miR-509-3p:PITA TOP PITA 8.525E-3 3.546E-2
2.134E-1
1.000E0
 1 103
35 TCCAGAT,MIR-516-5P:MSigDB TCCAGAT,MIR-516-5P:MSigDB MSigDB 8.525E-3 3.546E-2
2.134E-1
1.000E0
 1 103
36 hsa-miR-1286:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.525E-3 3.546E-2
2.134E-1
1.000E0
 1 103
37 hsa-let-7g-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.772E-3 3.546E-2
2.134E-1
1.000E0
 1 106
38 hsa-miR-4693-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.937E-3 3.546E-2
2.134E-1
1.000E0
 1 108
39 hsa-miR-3124:mirSVR lowEffct hsa-miR-3124:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.102E-3 3.546E-2
2.134E-1
1.000E0
 1 110
40 hsa-miR-199b-5p:Functional MTI Functional MTI miRTarbase 9.184E-3 3.546E-2
2.134E-1
1.000E0
 1 111
41 hsa-miR-493-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.514E-3 3.546E-2
2.134E-1
1.000E0
 1 115
42 ATAAGCT,MIR-21:MSigDB ATAAGCT,MIR-21:MSigDB MSigDB 9.596E-3 3.546E-2
2.134E-1
1.000E0
 1 116
43 hsa-miR-589:PITA hsa-miR-589:PITA TOP PITA 9.761E-3 3.546E-2
2.134E-1
1.000E0
 1 118
44 GGCACTT,MIR-519E:MSigDB GGCACTT,MIR-519E:MSigDB MSigDB 1.001E-2 3.546E-2
2.134E-1
1.000E0
 1 121
45 hsa-miR-876-3p:PITA hsa-miR-876-3p:PITA TOP PITA 1.017E-2 3.546E-2
2.134E-1
1.000E0
 1 123
46 ACACTAC,MIR-142-3P:MSigDB ACACTAC,MIR-142-3P:MSigDB MSigDB 1.026E-2 3.546E-2
2.134E-1
1.000E0
 1 124
47 hsa-miR-525-3p:mirSVR highEffct hsa-miR-525-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.026E-2 3.546E-2
2.134E-1
1.000E0
 1 124
48 hsa-miR-4480:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.034E-2 3.546E-2
2.134E-1
1.000E0
 1 125
49 hsa-miR-192-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.042E-2 3.546E-2
2.134E-1
1.000E0
 1 126
50 hsa-miR-524-3p:mirSVR highEffct hsa-miR-524-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.050E-2 3.546E-2
2.134E-1
1.000E0
 1 127
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 2710 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000003849 AC1L1GUQ Stitch 1.965E-7 5.131E-4 4.352E-3 5.325E-4 3 50
2 CID000002956 A25152 Stitch 3.787E-7 5.131E-4 4.352E-3 1.026E-3 3 62
3 CID000061258 lead stearate Stitch 9.520E-7 8.600E-4 7.294E-3 2.580E-3 3 84
4 CID005288092 peptidomimetic inhibitor Stitch 1.130E-5 4.264E-3 3.617E-2 3.063E-2 3 191
5 4696 UP Ofloxacin [82419-36-1]; Up 200; 11uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.203E-5 4.264E-3 3.617E-2 3.259E-2 3 195
6 3397 DN Digoxigenin [1672-46-4]; Down 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.221E-5 4.264E-3 3.617E-2 3.309E-2 3 196
7 5069 UP Gemfibrozil [25812-30-0]; Up 200; 16uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.240E-5 4.264E-3 3.617E-2 3.360E-2 3 197
8 6648 UP Clomiphene citrate (Z,E) [50-41-9]; Up 200; 6.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.259E-5 4.264E-3 3.617E-2 3.411E-2 3 198
9 ctd:C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester CTD 5.413E-5 1.603E-2
1.360E-1
1.467E-1
 2 44
10 CID006330514 gallium selenide Stitch 2.627E-4 1.603E-2
1.360E-1
7.119E-1
 1 1
11 CID000234454 stenbolone Stitch 2.627E-4 1.603E-2
1.360E-1
7.119E-1
 1 1
12 CID000002667 AC1L1E6W Stitch 2.627E-4 1.603E-2
1.360E-1
7.119E-1
 1 1
13 CID000026708 AFCF Stitch 2.627E-4 1.603E-2
1.360E-1
7.119E-1
 1 1
14 CID005484142 Nitro Red Stitch 2.627E-4 1.603E-2
1.360E-1
7.119E-1
 1 1
15 CID006439576 pyracrenic acid Stitch 2.627E-4 1.603E-2
1.360E-1
7.119E-1
 1 1
16 CID006453972 Lilly 82537 Stitch 2.627E-4 1.603E-2
1.360E-1
7.119E-1
 1 1
17 CID000014717 AC1L24EU Stitch 2.627E-4 1.603E-2
1.360E-1
7.119E-1
 1 1
18 CID003016406 AMOZ Stitch 2.627E-4 1.603E-2
1.360E-1
7.119E-1
 1 1
19 CID000019667 bephenium Stitch 2.627E-4 1.603E-2
1.360E-1
7.119E-1
 1 1
20 CID000072823 p206 Stitch 2.627E-4 1.603E-2
1.360E-1
7.119E-1
 1 1
21 CID000067874 p-trifluoromethylphenol Stitch 3.916E-4 1.603E-2
1.360E-1
1.000E0
 2 118
22 CID000003049 dienol Stitch 5.197E-4 1.603E-2
1.360E-1
1.000E0
 2 136
23 CID003080547 Balenine Stitch 5.253E-4 1.603E-2
1.360E-1
1.000E0
 1 2
24 CID000007745 2-methylpentanol Stitch 5.253E-4 1.603E-2
1.360E-1
1.000E0
 1 2
25 CID005289611 DB04229 Stitch 5.253E-4 1.603E-2
1.360E-1
1.000E0
 1 2
26 CID000126057 cetylmannoside Stitch 5.253E-4 1.603E-2
1.360E-1
1.000E0
 1 2
27 CID000034025 NSC649691 Stitch 5.253E-4 1.603E-2
1.360E-1
1.000E0
 1 2
28 CID000163881 Cl3DpD Stitch 5.253E-4 1.603E-2
1.360E-1
1.000E0
 1 2
29 CID000165983 gallium sulfide Stitch 5.253E-4 1.603E-2
1.360E-1
1.000E0
 1 2
30 CID006453484 4'-carboxyphenyl 4-guanidinobenzoate Stitch 5.253E-4 1.603E-2
1.360E-1
1.000E0
 1 2
31 CID000189066 solidagenone Stitch 5.253E-4 1.603E-2
1.360E-1
1.000E0
 1 2
32 CID000069216 5-methylhydantoin Stitch 5.253E-4 1.603E-2
1.360E-1
1.000E0
 1 2
33 CID000160526 9OHAD Stitch 5.253E-4 1.603E-2
1.360E-1
1.000E0
 1 2
34 CID000033345 4'-CMGB Stitch 5.253E-4 1.603E-2
1.360E-1
1.000E0
 1 2
35 CID006449999 CbgA Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
36 CID005321461 baeomycesic acid Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
37 CID000127494 cortisol 17 beta acid Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
38 CID000060896 triple sulfa Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
39 CID000442786 AC1L9DEQ Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
40 CID000159898 AC1L4MOT Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
41 CID000063224 febrifugine Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
42 CID003082459 AC1MIYVS Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
43 CID006365230 AC1O4D2Y Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
44 CID003080727 d(ApT Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
45 CID000193387 2-hydroxy-4-phenylbutyrate Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
46 CID000156086 istamycin A Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
47 CID000070929 dibutylmagnesium Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
48 CID000086483 gentamicin X2 Stitch 7.879E-4 1.603E-2
1.360E-1
1.000E0
 1 3
49 2448 DN Puromycin dihydrochloride [58-58-2]; Down 200; 7.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 8.386E-4 1.603E-2
1.360E-1
1.000E0
 2 173
50 1643 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 8.776E-4 1.603E-2
1.360E-1
1.000E0
 2 177
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 367 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0887833 Carcinoma, Pancreatic Ductal DisGeNET Curated 7.168E-5 6.291E-3 4.079E-2 2.631E-2 2 44
2 C0023470 Myeloid Leukemia DisGeNET Curated 2.532E-4 6.291E-3 4.079E-2
9.292E-2
 3 484
3 C1961102 Precursor Cell Lymphoblastic Leukemia Lymphoma DisGeNET Curated 2.658E-4 6.291E-3 4.079E-2
9.754E-2
 3 492
4 cv:C1842930 Neutropenia, nonimmune chronic idiopathic, of adults Clinical Variations 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
5 C1257931 Mammary Neoplasms, Human DisGeNET BeFree 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
6 C1328514 Pigmentary retinal deposits DisGeNET Curated 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
7 C4021591 Reduced number of intrahepatic bile ducts DisGeNET Curated 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
8 C1861627 Butterfly vertebral arch DisGeNET Curated 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
9 C1861621 Intrahepatic duct deficiency DisGeNET Curated 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
10 OMIN:607847 NEUTROPENIA, NONIMMUNE CHRONIC IDIOPATHIC, OF ADULTS OMIM 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
11 OMIN:118450 ALAGILLE SYNDROME 1; ALGS1 OMIM 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
12 C2751288 Neutropenia, Severe Congenital, Autosomal Dominant 2 DisGeNET Curated 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
13 C1336858 Undifferentiated Gastric Carcinoma DisGeNET BeFree 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
14 cv:C2751288 Severe congenital neutropenia 2, autosomal dominant Clinical Variations 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
15 cv:C1956125 Alagille syndrome 1 Clinical Variations 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
16 OMIN:613107 NEUTROPENIA, SEVERE CONGENITAL, AUTOSOMAL DOMINANT 2; SCN2 OMIM 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
17 C1956125 Alagille Syndrome 1 DisGeNET Curated 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
18 C2930797 Hepatic ductular hypoplasia DisGeNET BeFree 3.085E-4 6.291E-3 4.079E-2
1.132E-1
 1 1
19 C0023480 Leukemia, Myelomonocytic, Chronic DisGeNET Curated 4.106E-4 7.678E-3 4.979E-2
1.507E-1
 2 105
20 C0039103 Synovitis DisGeNET Curated 4.184E-4 7.678E-3 4.979E-2
1.536E-1
 2 106
21 C1153706 Endometrial adenocarcinoma DisGeNET BeFree 5.630E-4 9.058E-3
5.873E-2
2.066E-1
 2 123
22 C1864828 ALZHEIMER DISEASE 10 DisGeNET Curated 6.170E-4 9.058E-3
5.873E-2
2.264E-1
 1 2
23 C1842930 Neutropenia, Nonimmune Chronic Idiopathic, Adult DisGeNET Curated 6.170E-4 9.058E-3
5.873E-2
2.264E-1
 1 2
24 OMIN:202700 NEUTROPENIA, SEVERE CONGENITAL, AUTOSOMAL DOMINANT 1; SCN1 OMIM 6.170E-4 9.058E-3
5.873E-2
2.264E-1
 1 2
25 C0155120 Corneal Dystrophy, Band-Shaped DisGeNET Curated 6.170E-4 9.058E-3
5.873E-2
2.264E-1
 1 2
26 C0018939 Hematological Disease DisGeNET Curated 7.285E-4 1.028E-2
6.668E-2
2.674E-1
 2 140
27 C0005940 Bone Diseases DisGeNET Curated 8.693E-4 1.096E-2
7.104E-2
3.190E-1
 2 153
28 C0243002 Tricuspid Atresia DisGeNET BeFree 9.254E-4 1.096E-2
7.104E-2
3.396E-1
 1 3
29 C1859966 Neutropenia, Severe Congenital, Autosomal Dominant 1 DisGeNET Curated 9.254E-4 1.096E-2
7.104E-2
3.396E-1
 1 3
30 C0344975 Pulmonary Atresia with Intact Ventricular Septum DisGeNET BeFree 9.254E-4 1.096E-2
7.104E-2
3.396E-1
 1 3
31 C4024644 Multiple small medullary renal cysts DisGeNET Curated 9.254E-4 1.096E-2
7.104E-2
3.396E-1
 1 3
32 C0027947 Neutropenia DisGeNET Curated 9.738E-4 1.117E-2
7.241E-2
3.574E-1
 2 162
33 C0677898 invasive cancer DisGeNET BeFree 1.047E-3 1.164E-2
7.548E-2
3.841E-1
 2 168
34 C4020790 Medullary sponge kidney disease DisGeNET Curated 1.234E-3 1.167E-2
7.568E-2
4.528E-1
 1 4
35 C3711381 Hereditary Diffuse Leukoencephalopathy with Spheroids DisGeNET Curated 1.234E-3 1.167E-2
7.568E-2
4.528E-1
 1 4
36 C1336554 T-Cell and NK-Cell Neoplasm DisGeNET BeFree 1.234E-3 1.167E-2
7.568E-2
4.528E-1
 1 4
37 C1837549 SPONDYLOCOSTAL DYSOSTOSIS, AUTOSOMAL RECESSIVE 2 DisGeNET Curated 1.234E-3 1.167E-2
7.568E-2
4.528E-1
 1 4
38 C3150902 C1q DEFICIENCY DisGeNET Curated 1.234E-3 1.167E-2
7.568E-2
4.528E-1
 1 4
39 C0376634 Craniofacial Abnormalities DisGeNET Curated 1.240E-3 1.167E-2
7.568E-2
4.552E-1
 2 183
40 C0023448 Lymphoid leukemia DisGeNET Curated 1.407E-3 1.204E-2
7.807E-2
5.162E-1
 2 195
41 C2931027 Neutropenia, severe chronic DisGeNET BeFree 1.542E-3 1.204E-2
7.807E-2
5.659E-1
 1 5
42 C1266071 Intraductal papillary-mucinous adenoma DisGeNET BeFree 1.542E-3 1.204E-2
7.807E-2
5.659E-1
 1 5
43 C0917715 Hajdu-Cheney Syndrome DisGeNET Curated 1.542E-3 1.204E-2
7.807E-2
5.659E-1
 1 5
44 C0393799 Miller Fisher Syndrome DisGeNET BeFree 1.542E-3 1.204E-2
7.807E-2
5.659E-1
 1 5
45 C1367554 Adamantinoma DisGeNET BeFree 1.542E-3 1.204E-2
7.807E-2
5.659E-1
 1 5
46 C0266548 Axenfeld anomaly (disorder) DisGeNET Curated 1.542E-3 1.204E-2
7.807E-2
5.659E-1
 1 5
47 C1318543 Fibrous histiocytoma of tendon sheath DisGeNET BeFree 1.542E-3 1.204E-2
7.807E-2
5.659E-1
 1 5
48 C0948368 Kaufman-McKusick syndrome DisGeNET Curated 1.850E-3 1.415E-2
9.172E-2
6.790E-1
 1 6
49 C0023530 Leukopenia DisGeNET Curated 2.052E-3 1.467E-2
9.511E-2
7.530E-1
 2 236
50 C0398593 Specific granule deficiency DisGeNET Curated 2.158E-3 1.467E-2
9.511E-2
7.921E-1
 1 7
Show 45 more annotations