Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc215_13, positive side

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1: GO: Molecular Function [Display Chart] 13 input genes in category / 66 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004674 protein serine/threonine kinase activity 2.041E-4 1.092E-2
5.213E-2
 1.347E-2 4 452
2 GO:0000287 magnesium ion binding 3.494E-4 1.092E-2
5.213E-2
 2.306E-2 3 206
3 GO:0004712 protein serine/threonine/tyrosine kinase activity 4.963E-4 1.092E-2
5.213E-2
 3.276E-2 2 48
4 GO:0008094 DNA-dependent ATPase activity 1.849E-3 1.785E-2
8.520E-2
1.220E-1
 2 93
5 GO:0000403 Y-form DNA binding 2.784E-3 1.785E-2
8.520E-2
1.837E-1
 1 4
6 GO:0003917 DNA topoisomerase type I activity 2.784E-3 1.785E-2
8.520E-2
1.837E-1
 1 4
7 GO:0071987 WD40-repeat domain binding 2.784E-3 1.785E-2
8.520E-2
1.837E-1
 1 4
8 GO:0097100 supercoiled DNA binding 2.784E-3 1.785E-2
8.520E-2
1.837E-1
 1 4
9 GO:0030619 U1 snRNA binding 3.479E-3 1.785E-2
8.520E-2
2.296E-1
 1 5
10 GO:0009378 four-way junction helicase activity 3.479E-3 1.785E-2
8.520E-2
2.296E-1
 1 5
11 GO:1990446 U1 snRNP binding 3.479E-3 1.785E-2
8.520E-2
2.296E-1
 1 5
12 GO:0051880 G-quadruplex DNA binding 4.173E-3 1.785E-2
8.520E-2
2.754E-1
 1 6
13 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity 4.173E-3 1.785E-2
8.520E-2
2.754E-1
 1 6
14 GO:0061505 DNA topoisomerase II activity 4.173E-3 1.785E-2
8.520E-2
2.754E-1
 1 6
15 GO:0019903 protein phosphatase binding 4.245E-3 1.785E-2
8.520E-2
2.802E-1
 2 142
16 GO:0070990 snRNP binding 4.867E-3 1.785E-2
8.520E-2
3.212E-1
 1 7
17 GO:0043140 ATP-dependent 3'-5' DNA helicase activity 4.867E-3 1.785E-2
8.520E-2
3.212E-1
 1 7
18 GO:0000405 bubble DNA binding 4.867E-3 1.785E-2
8.520E-2
3.212E-1
 1 7
19 GO:0003916 DNA topoisomerase activity 5.561E-3 1.932E-2
9.222E-2
3.670E-1
 1 8
20 GO:0004713 protein tyrosine kinase activity 6.875E-3 2.079E-2
9.926E-2
4.538E-1
 2 182
21 GO:0001222 transcription corepressor binding 6.946E-3 2.079E-2
9.926E-2
4.585E-1
 1 10
22 GO:0008190 eukaryotic initiation factor 4E binding 6.946E-3 2.079E-2
9.926E-2
4.585E-1
 1 10
23 GO:0019902 phosphatase binding 7.245E-3 2.079E-2
9.926E-2
4.782E-1
 2 187
24 GO:0043138 3'-5' DNA helicase activity 9.021E-3 2.382E-2
1.137E-1
5.954E-1
 1 13
25 GO:0043522 leucine zipper domain binding 9.021E-3 2.382E-2
1.137E-1
5.954E-1
 1 13
26 GO:0030275 LRR domain binding 1.385E-2 3.515E-2
1.678E-1
9.140E-1
 1 20
27 GO:0008157 protein phosphatase 1 binding 1.522E-2 3.621E-2
1.729E-1
1.000E0
 1 22
28 GO:0071889 14-3-3 protein binding 1.591E-2 3.621E-2
1.729E-1
1.000E0
 1 23
29 GO:0030371 translation repressor activity 1.591E-2 3.621E-2
1.729E-1
1.000E0
 1 23
30 GO:0036002 pre-mRNA binding 1.728E-2 3.679E-2
1.757E-1
1.000E0
 1 25
31 GO:0000217 DNA secondary structure binding 1.728E-2 3.679E-2
1.757E-1
1.000E0
 1 25
32 GO:0001221 transcription cofactor binding 2.071E-2 4.270E-2
2.039E-1
1.000E0
 1 30
33 GO:0042623 ATPase activity, coupled 2.163E-2 4.325E-2
2.065E-1
1.000E0
 2 332
34 GO:0031369 translation initiation factor binding 2.412E-2 4.422E-2
2.111E-1
1.000E0
 1 35
35 GO:0017069 snRNA binding 2.412E-2 4.422E-2
2.111E-1
1.000E0
 1 35
36 GO:0051721 protein phosphatase 2A binding 2.412E-2 4.422E-2
2.111E-1
1.000E0
 1 35
Show 31 more annotations

2: GO: Biological Process [Display Chart] 13 input genes in category / 259 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008380 RNA splicing 5.152E-11 1.334E-8 8.188E-8 1.334E-8 8 402
2 GO:0000398 mRNA splicing, via spliceosome 4.655E-10 3.301E-8 2.025E-7 1.206E-7 7 305
3 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 4.655E-10 3.301E-8 2.025E-7 1.206E-7 7 305
4 GO:0000375 RNA splicing, via transesterification reactions 5.098E-10 3.301E-8 2.025E-7 1.320E-7 7 309
5 GO:0043484 regulation of RNA splicing 7.764E-9 4.022E-7 2.468E-6 2.011E-6 5 109
6 GO:0006397 mRNA processing 1.070E-8 4.620E-7 2.835E-6 2.772E-6 7 479
7 GO:0048024 regulation of mRNA splicing, via spliceosome 1.351E-7 4.999E-6 3.067E-5 3.499E-5 4 71
8 GO:0050684 regulation of mRNA processing 8.200E-7 2.655E-5 1.629E-4 2.124E-4 4 111
9 GO:1903311 regulation of mRNA metabolic process 1.544E-6 4.443E-5 2.726E-4 3.998E-4 4 130
10 GO:0045070 positive regulation of viral genome replication 1.935E-4 5.012E-3 3.076E-2
5.012E-2
 2 30
11 GO:0045071 negative regulation of viral genome replication 5.848E-4 1.137E-2
6.978E-2
1.515E-1
 2 52
12 GO:1904567 response to wortmannin 6.981E-4 1.137E-2
6.978E-2
1.808E-1
 1 1
13 GO:0035063 nuclear speck organization 6.981E-4 1.137E-2
6.978E-2
1.808E-1
 1 1
14 GO:1904568 cellular response to wortmannin 6.981E-4 1.137E-2
6.978E-2
1.808E-1
 1 1
15 GO:1990646 cellular response to prolactin 6.981E-4 1.137E-2
6.978E-2
1.808E-1
 1 1
16 GO:0000245 spliceosomal complex assembly 7.025E-4 1.137E-2
6.978E-2
1.820E-1
 2 57
17 GO:0006369 termination of RNA polymerase II transcription 8.308E-4 1.266E-2
7.766E-2
2.152E-1
 2 62
18 GO:0071103 DNA conformation change 9.053E-4 1.303E-2
7.993E-2
2.345E-1
 3 285
19 GO:0045069 regulation of viral genome replication 1.378E-3 1.879E-2
1.153E-1
3.570E-1
 2 80
20 GO:1903902 positive regulation of viral life cycle 1.627E-3 1.923E-2
1.180E-1
4.215E-1
 2 87
21 GO:1901655 cellular response to ketone 1.702E-3 1.923E-2
1.180E-1
4.409E-1
 2 89
22 GO:0031124 mRNA 3'-end processing 1.817E-3 1.923E-2
1.180E-1
4.707E-1
 2 92
23 GO:1903901 negative regulation of viral life cycle 1.817E-3 1.923E-2
1.180E-1
4.707E-1
 2 92
24 GO:0048524 positive regulation of viral process 1.896E-3 1.923E-2
1.180E-1
4.911E-1
 2 94
25 GO:0048525 negative regulation of viral process 1.936E-3 1.923E-2
1.180E-1
5.015E-1
 2 95
26 GO:1990637 response to prolactin 2.093E-3 1.923E-2
1.180E-1
5.420E-1
 1 3
27 GO:1904715 negative regulation of chaperone-mediated autophagy 2.093E-3 1.923E-2
1.180E-1
5.420E-1
 1 3
28 GO:1990928 response to amino acid starvation 2.093E-3 1.923E-2
1.180E-1
5.420E-1
 1 3
29 GO:0006353 DNA-templated transcription, termination 2.228E-3 1.923E-2
1.180E-1
5.770E-1
 2 102
30 GO:0019079 viral genome replication 2.228E-3 1.923E-2
1.180E-1
5.770E-1
 2 102
31 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 2.403E-3 1.945E-2
1.193E-1
6.223E-1
 2 106
32 GO:0006406 mRNA export from nucleus 2.403E-3 1.945E-2
1.193E-1
6.223E-1
 2 106
33 GO:0061084 negative regulation of protein refolding 2.790E-3 2.125E-2
1.304E-1
7.225E-1
 1 4
34 GO:0040009 regulation of growth rate 2.790E-3 2.125E-2
1.304E-1
7.225E-1
 1 4
35 GO:0006405 RNA export from nucleus 3.066E-3 2.146E-2
1.317E-1
7.941E-1
 2 120
36 GO:0031123 RNA 3'-end processing 3.066E-3 2.146E-2
1.317E-1
7.941E-1
 2 120
37 GO:0071426 ribonucleoprotein complex export from nucleus 3.066E-3 2.146E-2
1.317E-1
7.941E-1
 2 120
38 GO:0071166 ribonucleoprotein complex localization 3.218E-3 2.193E-2
1.346E-1
8.335E-1
 2 123
39 GO:0061083 regulation of protein refolding 3.486E-3 2.257E-2
1.385E-1
9.028E-1
 1 5
40 GO:1903333 negative regulation of protein folding 3.486E-3 2.257E-2
1.385E-1
9.028E-1
 1 5
41 GO:0016925 protein sumoylation 4.145E-3 2.461E-2
1.510E-1
1.000E0
 2 140
42 GO:0001302 replicative cell aging 4.182E-3 2.461E-2
1.510E-1
1.000E0
 1 6
43 GO:0000395 mRNA 5'-splice site recognition 4.182E-3 2.461E-2
1.510E-1
1.000E0
 1 6
44 GO:0071352 cellular response to interleukin-2 4.182E-3 2.461E-2
1.510E-1
1.000E0
 1 6
45 GO:0006997 nucleus organization 4.620E-3 2.659E-2
1.632E-1
1.000E0
 2 148
46 GO:0051028 mRNA transport 4.804E-3 2.688E-2
1.649E-1
1.000E0
 2 151
47 GO:1904714 regulation of chaperone-mediated autophagy 4.877E-3 2.688E-2
1.649E-1
1.000E0
 1 7
48 GO:0040016 embryonic cleavage 5.572E-3 2.861E-2
1.756E-1
1.000E0
 1 8
49 GO:0075713 establishment of integrated proviral latency 5.572E-3 2.861E-2
1.756E-1
1.000E0
 1 8
50 GO:0043901 negative regulation of multi-organism process 5.775E-3 2.861E-2
1.756E-1
1.000E0
 2 166
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 13 input genes in category / 50 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005681 spliceosomal complex 4.396E-6 1.991E-4 8.959E-4 2.198E-4 4 173
2 GO:0016607 nuclear speck 7.965E-6 1.991E-4 8.959E-4 3.982E-4 4 201
3 GO:0016604 nuclear body 8.160E-5 1.360E-3 6.119E-3 4.080E-3 4 364
4 GO:0043596 nuclear replication fork 3.469E-4 4.336E-3 1.951E-2 1.734E-2 2 41
5 GO:0005657 replication fork 9.259E-4 9.259E-3 4.166E-2 4.630E-2 2 67
6 GO:0071013 catalytic step 2 spliceosome 1.662E-3 1.385E-2
6.233E-2
8.312E-2
 2 90
7 GO:0035061 interchromatin granule 2.726E-3 1.833E-2
8.246E-2
1.363E-1
 1 4
8 GO:0001651 dense fibrillar component 3.406E-3 1.833E-2
8.246E-2
1.703E-1
 1 5
9 GO:0034399 nuclear periphery 3.690E-3 1.833E-2
8.246E-2
1.845E-1
 2 135
10 GO:0031298 replication fork protection complex 4.086E-3 1.833E-2
8.246E-2
2.043E-1
 1 6
11 GO:0089701 U2AF 4.086E-3 1.833E-2
8.246E-2
2.043E-1
 1 6
12 GO:0032389 MutLalpha complex 4.765E-3 1.833E-2
8.246E-2
2.383E-1
 1 7
13 GO:0000243 commitment complex 4.765E-3 1.833E-2
8.246E-2
2.383E-1
 1 7
14 GO:0001650 fibrillar center 6.123E-3 2.187E-2
9.838E-2
3.061E-1
 1 9
15 GO:0000974 Prp19 complex 9.509E-3 3.017E-2
1.357E-1
4.755E-1
 1 14
16 GO:0032300 mismatch repair complex 1.019E-2 3.017E-2
1.357E-1
5.093E-1
 1 15
17 GO:0071004 U2-type prespliceosome 1.086E-2 3.017E-2
1.357E-1
5.430E-1
 1 16
18 GO:0005662 DNA replication factor A complex 1.086E-2 3.017E-2
1.357E-1
5.430E-1
 1 16
19 GO:0005685 U1 snRNP 1.154E-2 3.036E-2
1.366E-1
5.768E-1
 1 17
20 GO:0035327 transcriptionally active chromatin 1.423E-2 3.389E-2
1.525E-1
7.116E-1
 1 21
21 GO:0071010 prespliceosome 1.423E-2 3.389E-2
1.525E-1
7.116E-1
 1 21
22 GO:0071011 precatalytic spliceosome 1.558E-2 3.541E-2
1.593E-1
7.789E-1
 1 23
23 GO:0043601 nuclear replisome 1.894E-2 4.116E-2
1.852E-1
9.468E-1
 1 28
24 GO:0005684 U2-type spliceosomal complex 2.094E-2 4.189E-2
1.885E-1
1.000E0
 1 31
25 GO:0030894 replisome 2.094E-2 4.189E-2
1.885E-1
1.000E0
 1 31
Show 20 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 285 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 8 input genes in category / 281 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0005608 cardiac interstitial fibrosis 2.329E-5 6.543E-3 4.068E-2 6.543E-3 3 79
2 MP:0003141 cardiac fibrosis 3.810E-4 3.618E-2
2.250E-1
1.071E-1
 3 202
3 MP:0005337 abnormal retroperitoneal fat pad morphology 4.861E-4 3.618E-2
2.250E-1
1.366E-1
 2 44
4 MP:0000010 abnormal abdominal fat pad morphology 7.370E-4 3.618E-2
2.250E-1
2.071E-1
 3 253
5 MP:0030288 broad occipital bone 7.726E-4 3.618E-2
2.250E-1
2.171E-1
 1 1
6 MP:0008901 absent epididymal fat pad 7.726E-4 3.618E-2
2.250E-1
2.171E-1
 1 1
7 MP:0005336 abnormal inguinal fat pad morphology 1.194E-3 4.333E-2
2.694E-1
3.355E-1
 2 69
8 MP:0005334 abnormal fat pad morphology 1.233E-3 4.333E-2
2.694E-1
3.466E-1
 3 302
9 MP:0030289 flat occipital bone 1.545E-3 4.340E-2
2.699E-1
4.340E-1
 1 2
10 MP:0030287 enlarged occipital bone 1.545E-3 4.340E-2
2.699E-1
4.340E-1
 1 2
Show 5 more annotations

6: Domain [Display Chart] 13 input genes in category / 101 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR017441 Protein kinase ATP BS InterPro 1.020E-4 3.418E-3 1.776E-2 1.030E-2 4 379
2 PF00069 Pkinase Pfam 1.041E-4 3.418E-3 1.776E-2 1.051E-2 4 381
3 PS00107 PROTEIN KINASE ATP PROSITE 2.133E-4 3.418E-3 1.776E-2 2.154E-2 4 459
4 IPR000719 Prot kinase dom InterPro 2.718E-4 3.418E-3 1.776E-2 2.745E-2 4 489
5 PS50011 PROTEIN KINASE DOM PROSITE 2.804E-4 3.418E-3 1.776E-2 2.832E-2 4 493
6 PF00076 RRM 1 Pfam 3.554E-4 3.418E-3 1.776E-2 3.589E-2 3 208
7 SM00360 RRM SMART 4.023E-4 3.418E-3 1.776E-2 4.063E-2 3 217
8 IPR000504 RRM dom InterPro 4.589E-4 3.418E-3 1.776E-2 4.635E-2 3 227
9 PS50102 RRM PROSITE 4.769E-4 3.418E-3 1.776E-2 4.817E-2 3 230
10 IPR012677 Nucleotide-bd a/b plait InterPro 6.665E-4 3.418E-3 1.776E-2
6.732E-2
 3 258
11 PF11831 Myb Cef Pfam 6.939E-4 3.418E-3 1.776E-2
7.008E-2
 1 1
12 IPR022023 U1snRNP70 N InterPro 6.939E-4 3.418E-3 1.776E-2
7.008E-2
 1 1
13 PF14493 HTH 40 Pfam 6.939E-4 3.418E-3 1.776E-2
7.008E-2
 1 1
14 PF12220 U1snRNP70 N Pfam 6.939E-4 3.418E-3 1.776E-2
7.008E-2
 1 1
15 IPR021786 Cdc5p/Cef1 InterPro 6.939E-4 3.418E-3 1.776E-2
7.008E-2
 1 1
16 IPR029491 Helicase HTH InterPro 6.939E-4 3.418E-3 1.776E-2
7.008E-2
 1 1
17 IPR015782 TESK1 InterPro 6.939E-4 3.418E-3 1.776E-2
7.008E-2
 1 1
18 PF14370 Topo C assoc Pfam 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
19 SM00435 TOPEUc SMART 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
20 IPR025834 TopoI C dom InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
21 PF02919 Topoisom I N Pfam 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
22 PS00176 TOPOISOMERASE I EUK PROSITE 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
23 IPR001631 TopoI InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
24 IPR017859 Treacle-like TCS InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
25 IPR013034 DNA topo domain1 InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
26 IPR014727 TopoI cat a/b-sub euk InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
27 1.10.10.41 - Gene3D 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
28 IPR013500 TopoI cat euk InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
29 PF11467 LEDGF Pfam 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
30 IPR008336 TopoI DNA-bd euk InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
31 IPR011010 DNA brk join enz InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
32 IPR014711 TopoI cat a-hlx-sub euk InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
33 SM00956 RQC SMART 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
34 IPR018521 TopoI AS InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
35 IPR013030 TopoI DNA-bd mixed-a/b euk InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
36 PF01028 Topoisom I Pfam 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
37 IPR013499 TopoI euk InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
38 1.10.132.10 - Gene3D 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
39 2.170.11.10 - Gene3D 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
40 IPR021567 LEDGF InterPro 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
41 3.90.15.10 - Gene3D 1.387E-3 3.418E-3 1.776E-2
1.401E-1
 1 2
42 IPR008271 Ser/Thr kinase AS InterPro 1.702E-3 3.891E-3 2.022E-2
1.720E-1
 3 357
43 SM00220 S TKc SMART 1.730E-3 3.891E-3 2.022E-2
1.747E-1
 3 359
44 PS00108 PROTEIN KINASE ST PROSITE 1.772E-3 3.891E-3 2.022E-2
1.789E-1
 3 362
45 PF07092 DUF1356 Pfam 2.080E-3 3.891E-3 2.022E-2
2.101E-1
 1 3
46 PF00570 HRDC Pfam 2.080E-3 3.891E-3 2.022E-2
2.101E-1
 1 3
47 IPR018982 RQC domain InterPro 2.080E-3 3.891E-3 2.022E-2
2.101E-1
 1 3
48 IPR008606 EIF4EBP InterPro 2.080E-3 3.891E-3 2.022E-2
2.101E-1
 1 3
49 PF05456 eIF 4EBP Pfam 2.080E-3 3.891E-3 2.022E-2
2.101E-1
 1 3
50 1.10.150.80 - Gene3D 2.080E-3 3.891E-3 2.022E-2
2.101E-1
 1 3
Show 45 more annotations

7: Pathway [Display Chart] 11 input genes in category / 96 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 125136 Spliceosome BioSystems: KEGG 3.994E-6 3.834E-4 1.973E-3 3.834E-4 4 134
2 1269690 mRNA Splicing - Major Pathway BioSystems: REACTOME 1.530E-5 5.770E-4 2.969E-3 1.469E-3 4 188
3 1269689 mRNA Splicing BioSystems: REACTOME 1.803E-5 5.770E-4 2.969E-3 1.731E-3 4 196
4 1269688 Processing of Capped Intron-Containing Pre-mRNA BioSystems: REACTOME 4.543E-5 1.090E-3 5.611E-3 4.361E-3 4 248
5 1269692 mRNA 3'-end processing BioSystems: REACTOME 1.346E-3 2.311E-2
1.190E-1
1.292E-1
 2 63
6 1269685 RNA Polymerase II Transcription Termination BioSystems: REACTOME 1.754E-3 2.311E-2
1.190E-1
1.684E-1
 2 72
7 1269686 Cleavage of Growing Transcript in the Termination Region BioSystems: REACTOME 1.754E-3 2.311E-2
1.190E-1
1.684E-1
 2 72
8 1269694 Transport of Mature mRNA derived from an Intron-Containing Transcript BioSystems: REACTOME 1.952E-3 2.311E-2
1.190E-1
1.874E-1
 2 76
9 1269693 Transport of Mature Transcript to Cytoplasm BioSystems: REACTOME 2.606E-3 2.311E-2
1.190E-1
2.502E-1
 2 88
10 1269068 Autointegration results in viral DNA circles BioSystems: REACTOME 2.648E-3 2.311E-2
1.190E-1
2.543E-1
 1 3
11 1269066 Integration of viral DNA into host genomic DNA BioSystems: REACTOME 2.648E-3 2.311E-2
1.190E-1
2.543E-1
 1 3
12 1268743 SUMO E3 ligases SUMOylate target proteins BioSystems: REACTOME 3.619E-3 2.895E-2
1.490E-1
3.474E-1
 2 104
13 1268738 SUMOylation BioSystems: REACTOME 4.039E-3 2.983E-2
1.535E-1
3.877E-1
 2 110
14 1269097 APOBEC3G mediated resistance to HIV-1 infection BioSystems: REACTOME 4.411E-3 3.024E-2
1.557E-1
4.234E-1
 1 5
15 1269067 2-LTR circle formation BioSystems: REACTOME 6.170E-3 3.949E-2
2.032E-1
5.923E-1
 1 7
16 1270239 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components BioSystems: REACTOME 7.048E-3 4.229E-2
2.177E-1
6.766E-1
 1 8
17 1269065 Integration of provirus BioSystems: REACTOME 7.926E-3 4.476E-2
2.304E-1
7.609E-1
 1 9
18 1269675 RNA Polymerase II Transcription BioSystems: REACTOME 8.568E-3 4.570E-2
2.352E-1
8.226E-1
 2 162
Show 13 more annotations

8: Pubmed [Display Chart] 13 input genes in category / 1929 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9472028 SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. Pubmed 1.504E-15 2.901E-12 2.362E-11 2.901E-12 5 12
2 21907836 Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Pubmed 2.409E-11 1.485E-8 1.210E-7 4.648E-8 6 191
3 22365833 Dynamic protein-protein interaction wiring of the human spliceosome. Pubmed 2.905E-11 1.485E-8 1.210E-7 5.604E-8 6 197
4 12417631 Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. Pubmed 3.080E-11 1.485E-8 1.210E-7 5.942E-8 3 3
5 8261509 Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Pubmed 1.232E-10 4.753E-8 3.870E-7 2.376E-7 3 4
6 21157427 Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. Pubmed 3.079E-10 8.485E-8 6.909E-7 5.940E-7 3 5
7 12565863 Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Pubmed 3.079E-10 8.485E-8 6.909E-7 5.940E-7 3 5
8 8798720 SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. Pubmed 6.157E-10 1.485E-7 1.209E-6 1.188E-6 3 6
9 8816452 Functional properties of p54, a novel SR protein active in constitutive and alternative splicing. Pubmed 1.077E-9 1.889E-7 1.538E-6 2.078E-6 3 7
10 9237760 A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA. Pubmed 1.077E-9 1.889E-7 1.538E-6 2.078E-6 3 7
11 18559666 Spatial mapping of splicing factor complexes involved in exon and intron definition. Pubmed 1.077E-9 1.889E-7 1.538E-6 2.078E-6 3 7
12 11448987 ZNF265--a novel spliceosomal protein able to induce alternative splicing. Pubmed 2.584E-9 4.154E-7 3.383E-6 4.985E-6 3 9
13 21182205 Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. Pubmed 1.287E-8 1.910E-6 1.555E-5 2.482E-5 5 245
14 17332742 Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. Pubmed 5.461E-8 7.524E-6 6.126E-5 1.053E-4 4 115
15 9731529 Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. Pubmed 7.054E-8 8.970E-6 7.303E-5 1.361E-4 3 25
16 16122776 Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein. Pubmed 1.069E-7 8.970E-6 7.303E-5 2.063E-4 2 2
17 12134018 Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein. Pubmed 1.069E-7 8.970E-6 7.303E-5 2.063E-4 2 2
18 20498328 Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Pubmed 1.069E-7 8.970E-6 7.303E-5 2.063E-4 2 2
19 26244849 Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340). Pubmed 1.069E-7 8.970E-6 7.303E-5 2.063E-4 2 2
20 26959889 Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer. Pubmed 1.069E-7 8.970E-6 7.303E-5 2.063E-4 2 2
21 21205200 Serine-arginine protein kinases: a small protein kinase family with a large cellular presence. Pubmed 1.069E-7 8.970E-6 7.303E-5 2.063E-4 2 2
22 9446799 Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Pubmed 1.069E-7 8.970E-6 7.303E-5 2.063E-4 2 2
23 27397683 Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing. Pubmed 1.069E-7 8.970E-6 7.303E-5 2.063E-4 2 2
24 27639445 Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications. Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
25 25964599 Mutations in the Spliceosomal Machinery Genes SRSF2, U2AF1, and ZRSR2 and Response to Decitabine in Myelodysplastic Syndrome. Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
26 16223727 Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
27 23280334 Mutational analysis of splicing machinery genes SF3B1, U2AF1 and SRSF2 in myelodysplasia and other common tumors. Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
28 10196197 The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
29 23707382 Partitioning RS domain phosphorylation in an SR protein through the CLK and SRPK protein kinases. Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
30 30194306 Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia. Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
31 22389253 Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes. Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
32 23335386 Spliceosome mutations involving SRSF2, SF3B1, and U2AF35 in chronic myelomonocytic leukemia: prevalence, clinical correlates, and prognostic relevance. Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
33 16223718 The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
34 29335301 Mobilization of a splicing factor through a nuclear kinase-kinase complex. Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
35 22323480 Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis. Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
36 25529026 Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function. Pubmed 3.208E-7 1.719E-5 1.400E-4 6.188E-4 2 3
37 9799243 Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. Pubmed 6.414E-7 3.256E-5 2.651E-4 1.237E-3 2 4
38 11756244 Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue. Pubmed 6.414E-7 3.256E-5 2.651E-4 1.237E-3 2 4
39 26641092 The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells. Pubmed 1.023E-6 5.029E-5 4.095E-4 1.973E-3 4 239
40 9016565 Association of U2 snRNP with the spliceosomal complex E. Pubmed 1.069E-6 5.029E-5 4.095E-4 2.062E-3 2 5
41 25231745 SRSF2 and U2AF1 mutations in primary myelofibrosis are associated with JAK2 and MPL but not calreticulin mutation and may independently reoccur after allogeneic stem cell transplantation. Pubmed 1.069E-6 5.029E-5 4.095E-4 2.062E-3 2 5
42 15652350 CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing. Pubmed 1.603E-6 7.191E-5 5.855E-4 3.092E-3 2 6
43 19592491 Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. Pubmed 1.603E-6 7.191E-5 5.855E-4 3.092E-3 2 6
44 28561026 R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein. Pubmed 2.523E-6 1.106E-4 9.006E-4 4.867E-3 4 300
45 9447963 Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing. Pubmed 2.991E-6 1.254E-4 1.021E-3 5.770E-3 2 8
46 8208298 A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Pubmed 2.991E-6 1.254E-4 1.021E-3 5.770E-3 2 8
47 23151878 Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. Pubmed 3.557E-6 1.460E-4 1.189E-3 6.862E-3 3 90
48 10198174 Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes. Pubmed 3.845E-6 1.545E-4 1.258E-3 7.417E-3 2 9
49 11500380 A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. Pubmed 4.805E-6 1.892E-4 1.540E-3 9.269E-3 2 10
50 26167880 SR protein kinases promote splicing of nonconsensus introns. Pubmed 5.247E-6 2.024E-4 1.648E-3 1.012E-2 4 361
Show 45 more annotations

9: Interaction [Display Chart] 13 input genes in category / 1578 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SRSF1 SRSF1 interactions 1.365E-15 2.154E-12 1.711E-11 2.154E-12 9 195
2 int:SRSF2 SRSF2 interactions 2.885E-12 2.277E-9 1.808E-8 4.553E-9 7 141
3 int:ZRANB2 ZRANB2 interactions 2.782E-11 1.463E-8 1.162E-7 4.390E-8 6 92
4 int:U2AF2 U2AF2 interactions 6.551E-11 2.584E-8 2.052E-7 1.034E-7 8 394
5 int:U2AF1 U2AF1 interactions 2.888E-10 9.115E-8 7.239E-7 4.558E-7 6 135
6 int:RBM39 RBM39 interactions 1.700E-9 4.471E-7 3.551E-6 2.683E-6 6 181
7 int:CHERP CHERP interactions 2.828E-9 5.740E-7 4.558E-6 4.463E-6 5 85
8 int:SON SON interactions 3.002E-9 5.740E-7 4.558E-6 4.737E-6 5 86
9 int:TRA2B TRA2B interactions 3.701E-9 5.740E-7 4.558E-6 5.840E-6 6 206
10 int:RNPS1 RNPS1 interactions 3.922E-9 5.740E-7 4.558E-6 6.189E-6 6 208
11 int:YTHDC1 YTHDC1 interactions 4.001E-9 5.740E-7 4.558E-6 6.314E-6 5 91
12 int:HDGF HDGF interactions 5.797E-9 7.228E-7 5.740E-6 9.147E-6 6 222
13 int:SNRNP70 SNRNP70 interactions 5.955E-9 7.228E-7 5.740E-6 9.397E-6 6 223
14 int:ARGLU1 ARGLU1 interactions 8.007E-9 9.025E-7 7.167E-6 1.263E-5 4 34
15 int:SRPK2 SRPK2 interactions 1.216E-8 1.250E-6 9.925E-6 1.919E-5 7 464
16 int:SRPK1 SRPK1 interactions 1.267E-8 1.250E-6 9.925E-6 2.000E-5 6 253
17 int:SRRM2 SRRM2 interactions 1.995E-8 1.852E-6 1.471E-5 3.149E-5 6 273
18 int:SRSF5 SRSF5 interactions 2.245E-8 1.927E-6 1.530E-5 3.542E-5 5 128
19 int:BARD1 BARD1 interactions 2.320E-8 1.927E-6 1.530E-5 3.661E-5 6 280
20 int:EIF4A3 EIF4A3 interactions 2.633E-8 2.077E-6 1.650E-5 4.154E-5 6 286
21 int:SCAF11 SCAF11 interactions 3.340E-8 2.510E-6 1.993E-5 5.271E-5 4 48
22 int:PRPF38A PRPF38A interactions 3.636E-8 2.608E-6 2.071E-5 5.737E-5 4 49
23 int:ZRSR2 ZRSR2 interactions 3.950E-8 2.710E-6 2.152E-5 6.234E-5 4 50
24 int:SNRPD1 SNRPD1 interactions 5.497E-8 3.469E-6 2.755E-5 8.674E-5 5 153
25 int:SRSF7 SRSF7 interactions 5.497E-8 3.469E-6 2.755E-5 8.674E-5 5 153
26 int:SRSF3 SRSF3 interactions 6.255E-8 3.796E-6 3.015E-5 9.870E-5 5 157
27 int:THRAP3 THRAP3 interactions 7.094E-8 4.146E-6 3.293E-5 1.119E-4 5 161
28 int:SRRM1 SRRM1 interactions 1.016E-7 5.726E-6 4.547E-5 1.603E-4 5 173
29 int:SRSF4 SRSF4 interactions 1.228E-7 6.683E-6 5.307E-5 1.938E-4 4 66
30 int:NCL NCL interactions 1.632E-7 8.582E-6 6.815E-5 2.575E-4 6 389
31 int:MAGOH MAGOH interactions 1.846E-7 9.394E-6 7.460E-5 2.912E-4 5 195
32 int:SREK1 SREK1 interactions 3.761E-7 1.855E-5 1.473E-4 5.935E-4 4 87
33 int:SRSF11 SRSF11 interactions 4.921E-7 2.353E-5 1.869E-4 7.766E-4 4 93
34 int:CLK2 CLK2 interactions 5.138E-7 2.385E-5 1.894E-4 8.108E-4 4 94
35 int:HNRNPK HNRNPK interactions 6.814E-7 3.072E-5 2.440E-4 1.075E-3 6 496
36 int:DHX9 DHX9 interactions 8.135E-7 3.566E-5 2.832E-4 1.284E-3 5 263
37 int:SAFB SAFB interactions 8.978E-7 3.829E-5 3.041E-4 1.417E-3 4 108
38 int:BCLAF1 BCLAF1 interactions 1.324E-6 5.499E-5 4.367E-4 2.090E-3 4 119
39 int:PRKDC PRKDC interactions 1.386E-6 5.606E-5 4.452E-4 2.187E-3 5 293
40 int:LCE3D LCE3D interactions 1.493E-6 5.694E-5 4.522E-4 2.356E-3 2 3
41 int:DAW1 DAW1 interactions 1.493E-6 5.694E-5 4.522E-4 2.356E-3 2 3
42 int:MAPKAPK5 MAPKAPK5 interactions 1.516E-6 5.694E-5 4.522E-4 2.392E-3 3 32
43 int:SRSF8 SRSF8 interactions 1.666E-6 6.116E-5 4.857E-4 2.630E-3 3 33
44 int:SART1 SART1 interactions 1.718E-6 6.161E-5 4.893E-4 2.711E-3 4 127
45 int:LUC7L LUC7L interactions 2.004E-6 7.029E-5 5.582E-4 3.163E-3 4 132
46 int:MTCL1 MTCL1 interactions 2.178E-6 7.472E-5 5.934E-4 3.437E-3 3 36
47 int:ZC3H18 ZC3H18 interactions 2.682E-6 9.005E-5 7.151E-4 4.232E-3 4 142
48 int:OCEL1 OCEL1 interactions 2.984E-6 9.310E-5 7.393E-4 4.709E-3 2 4
49 int:CSAG1 CSAG1 interactions 2.984E-6 9.310E-5 7.393E-4 4.709E-3 2 4
50 int:C16orf78 C16orf78 interactions 2.984E-6 9.310E-5 7.393E-4 4.709E-3 2 4
Show 45 more annotations

10: Cytoband [Display Chart] 13 input genes in category / 12 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 8p12 8p12 1.512E-4 1.814E-3 5.630E-3 1.814E-3 2 49
2 7q22-q31.1 7q22-q31.1 1.499E-3 8.997E-3 2.792E-2 1.799E-2 1 4
3 20q12-q13.1 20q12-q13.1 3.745E-3 1.498E-2 4.648E-2 4.494E-2 1 10
4 9p22.3 9p22.3 5.612E-3 1.684E-2
5.225E-2
6.735E-2
 1 15
5 9p13 9p13 8.594E-3 1.856E-2
5.758E-2
1.031E-1
 1 23
6 2q33 2q33 1.082E-2 1.856E-2
5.758E-2
1.299E-1
 1 29
7 7p21.3 7p21.3 1.082E-2 1.856E-2
5.758E-2
1.299E-1
 1 29
8 6p21.31 6p21.31 1.527E-2 2.291E-2
7.109E-2
1.833E-1
 1 41
9 6p21 6p21 2.264E-2 3.019E-2
9.369E-2
2.717E-1
 1 61
10 17q25.1 17q25.1 3.069E-2 3.388E-2
1.051E-1
3.683E-1
 1 83
11 19q13.3 19q13.3 3.106E-2 3.388E-2
1.051E-1
3.727E-1
 1 84
Show 6 more annotations

11: Transcription Factor Binding Site [Display Chart] 10 input genes in category / 144 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 8 input genes in category / 9 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 725 RNA binding motif containing genenames.org 8.484E-5 7.636E-4 2.160E-3 7.636E-4 3 213
2 480 CDC like kinases genenames.org 1.758E-3 5.534E-3 1.566E-2 1.582E-2 1 4
3 1049 Exonucleases|RecQ like helicases genenames.org 2.197E-3 5.534E-3 1.566E-2 1.977E-2 1 5
4 1050 Topoisomerases genenames.org 2.636E-3 5.534E-3 1.566E-2 2.372E-2 1 6
5 1361 Armadillo repeat containing|NineTeen complex genenames.org 3.074E-3 5.534E-3 1.566E-2 2.767E-2 1 7
6 737 RNA binding motif containing|Serine and arginine rich splicing factors genenames.org 5.265E-3 7.898E-3 2.234E-2 4.739E-2 1 12
7 544 Exonucleases genenames.org 7.015E-3 9.019E-3 2.552E-2
6.314E-2
 1 16
8 1147 PHD finger proteins|Lysine methyltransferases|PWWP domain containing genenames.org 9.635E-3 1.084E-2 3.066E-2
8.671E-2
 1 22
9 532 GATA zinc finger domain containing|Myb/SANT domain containing genenames.org 2.307E-2 2.307E-2
6.527E-2
2.077E-1
 1 53
Show 4 more annotations

13: Coexpression [Display Chart] 13 input genes in category / 1413 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M18501 Genes up-regulated by MYC [GeneID=4609], according to the MYC Target Gene Database. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.700E-8 8.053E-5 6.307E-4 8.053E-5 4 71
2 19014521-TableS6a Human Breast Reyal08 41genes GeneSigDB 1.459E-6 1.031E-3 8.072E-3 2.062E-3 3 41
3 M123 Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells, embryonical carcinomas and induced pluripotent cells). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.783E-5 8.397E-3
6.576E-2
 2.519E-2 4 299
4 12471243-TableS2 Human Manning02 624genes ProteinKinases GeneSigDB 4.018E-5 1.155E-2
9.042E-2
5.678E-2
 4 368
5 M2428 Down-regulated by induction of exogenous BRCA1 in EcR-293 cells MSigDB C2: CGP Curated Gene Sets (v6.0) 6.059E-5 1.155E-2
9.042E-2
8.562E-2
 3 141
6 M6506 Genes up-regulated by MYC [GeneID=4609] and whose promoters are bound by MYC, according to MYC Target Gene Database. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.318E-5 1.155E-2
9.042E-2
8.928E-2
 3 143
7 M9516 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.910E-5 1.155E-2
9.042E-2
9.763E-2
 4 423
8 M8927 Genes up-regulated in CD4 [GeneID=920] naïve versus Th17 enriched. MSigDB C7: Immunologic Signatures (v6.0) 7.428E-5 1.155E-2
9.042E-2
1.050E-1
 3 151
9 12925741-Figure8 Human Lymphoma Jenner03 279genes GeneSigDB 7.724E-5 1.155E-2
9.042E-2
1.091E-1
 3 153
10 18535662-TableS2b Mouse Lymphoma Wu08 1016genes GeneSigDB 9.563E-5 1.155E-2
9.042E-2
1.351E-1
 4 460
11 16936776-GeneList Human Breast Naderi07 200genes GeneSigDB 1.038E-4 1.155E-2
9.042E-2
1.466E-1
 3 169
12 M3401 Genes down-regulated in comparison of control microglia cells versus those 1 h after stimulation with IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 1.682E-4 1.155E-2
9.042E-2
2.377E-1
 3 199
13 M9685 Genes down-regulated in CD4 [GeneID=920] T helper cells Th17 treated with TGFB1 and IL6 [GeneID=7040;3569]: 1h versus 60h. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.155E-2
9.042E-2
2.412E-1
 3 200
14 M3960 Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.155E-2
9.042E-2
2.412E-1
 3 200
15 M5901 Genes involved in the G2/M checkpoint, as in progression through the cell division cycle. MSigDB H: Hallmark Gene Sets (v6.0) 1.707E-4 1.155E-2
9.042E-2
2.412E-1
 3 200
16 M4127 Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus those stimulated with CpG DNA (TLR9 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.155E-2
9.042E-2
2.412E-1
 3 200
17 M363 Genes up-regulated in macrophages differentiated in the presence of IL4 [GeneID=3565] and dexamethasone [PubChem=5743] for 5 days versus those subsequently treated with TGFB1 [GeneID=7040] for 24h. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.155E-2
9.042E-2
2.412E-1
 3 200
18 M7609 Genes down-regulated in CD11b BoneMarrow from BALBc mouse incubated with GMCSF and IL-6 versus CD11b BoneMarrow from BALBc mouse incubated with GMCSF and GCSF. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.155E-2
9.042E-2
2.412E-1
 3 200
19 M5926 A subgroup of genes regulated by MYC - version 1 (v1). MSigDB H: Hallmark Gene Sets (v6.0) 1.707E-4 1.155E-2
9.042E-2
2.412E-1
 3 200
20 M3832 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.155E-2
9.042E-2
2.412E-1
 3 200
21 15771776-Table1 Human Breast Woelfle05 38genes GeneSigDB 1.716E-4 1.155E-2
9.042E-2
2.425E-1
 2 35
22 M262 Genes discriminating responses to sodium arsenite [PubChem=26435] from other stresses. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.171E-4 1.394E-2
1.092E-1
3.068E-1
 3 217
23 14722241-Table1a Human Lung Chen04 54genes GeneSigDB 2.598E-4 1.596E-2
1.250E-1
3.670E-1
 2 43
24 15308739-Table1 Human Viral Krishnan04 59genes GeneSigDB 3.804E-4 2.239E-2
1.754E-1
5.374E-1
 2 52
25 M2589 Cluster 2: genes changed in primary keratinocytes by UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.102E-4 2.264E-2
1.773E-1
5.796E-1
 2 54
26 M15123 Genes down-regulated in at least 8 of 11 sarcoma cell lines by trabectedin [PubChem=3199]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.167E-4 2.264E-2
1.773E-1
5.887E-1
 3 271
27 12115547-Table4 Human Viral Ruutu02 64genes GeneSigDB 4.897E-4 2.563E-2
2.007E-1
6.920E-1
 2 59
28 11562467-Table3 Human Breast West01 100genes GeneSigDB 6.888E-4 3.386E-2
2.651E-1
9.733E-1
 2 70
29 M9150 Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.949E-4 3.386E-2
2.651E-1
9.819E-1
 3 323
30 M1858 Down-regulated genes in A2780 cells (ovarian cancer) treated with 17AAG [PubChem=6440175], a chemical with anticancer properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.762E-4 4.127E-2
3.232E-1
1.000E0
 2 79
31 15520196-SuppTable6a Mouse Breast Bae04 94genes BRCA1null down GeneSigDB 1.037E-3 4.728E-2
3.702E-1
1.000E0
 2 86
Show 26 more annotations

14: Coexpression Atlas [Display Chart] 13 input genes in category / 656 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 12 input genes in category / 112 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M10882 MORF SNRP70 Neighborhood of SNRP70 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.520E-5 3.064E-3 1.624E-2 5.062E-3 3 61
2 M8084 MODULE 183 RNA splicing. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.471E-5 3.064E-3 1.624E-2 6.127E-3 3 65
3 M10939 MORF UBE2I Neighborhood of UBE2I MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.314E-4 4.904E-3 2.599E-2 1.471E-2 4 238
4 M2705 MORF ACP1 Neighborhood of ACP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.728E-3 4.099E-2
2.172E-1
1.935E-1
 3 210
5 M18997 MORF XRCC5 Neighborhood of XRCC5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.355E-3 4.099E-2
2.172E-1
2.638E-1
 3 234
6 M4550 MODULE 252 TFs and nuclear. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.442E-3 4.099E-2
2.172E-1
2.735E-1
 3 237
7 M7466 MODULE 32 Genes in the cancer module 32. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.562E-3 4.099E-2
2.172E-1
2.869E-1
 3 241
Show 2 more annotations

16: MicroRNA [Display Chart] 13 input genes in category / 637 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-485-3p:PITA hsa-miR-485-3p:PITA TOP PITA 7.873E-7 5.015E-4 3.528E-3 5.015E-4 4 422
2 hsa-miR-1261:PITA hsa-miR-1261:PITA TOP PITA 9.131E-6 2.359E-3 1.659E-2 5.817E-3 3 232
3 ATTCTTT,MIR-186:MSigDB ATTCTTT,MIR-186:MSigDB MSigDB 1.183E-5 2.359E-3 1.659E-2 7.535E-3 3 253
4 hsa-miR-6077:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.584E-5 2.359E-3 1.659E-2 1.009E-2 3 279
5 ATGTACA,MIR-493:MSigDB ATGTACA,MIR-493:MSigDB MSigDB 1.851E-5 2.359E-3 1.659E-2 1.179E-2 3 294
6 hsa-miR-500:PITA hsa-miR-500:PITA TOP PITA 2.495E-5 2.597E-3 1.827E-2 1.590E-2 3 325
7 hsa-miR-501-5p:PITA hsa-miR-501-5p:PITA TOP PITA 2.854E-5 2.597E-3 1.827E-2 1.818E-2 3 340
8 hsa-miR-376a-2-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.499E-5 2.786E-3 1.960E-2 2.229E-2 2 49
9 hsa-miR-603:PITA hsa-miR-603:PITA TOP PITA 4.128E-5 2.922E-3 2.056E-2 2.630E-2 3 385
10 hsa-miR-145-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.260E-5 3.080E-3 2.167E-2 3.351E-2 2 60
11 GTATGAT,MIR-154:MSigDB GTATGAT,MIR-154:MSigDB MSigDB 5.802E-5 3.080E-3 2.167E-2 3.696E-2 2 63
12 GTATGAT,MIR-487:MSigDB GTATGAT,MIR-487:MSigDB MSigDB 5.802E-5 3.080E-3 2.167E-2 3.696E-2 2 63
13 hsa-miR-802:PITA hsa-miR-802:PITA TOP PITA 6.642E-5 3.152E-3 2.218E-2 4.231E-2 3 452
14 hsa-miR-1470:mirSVR lowEffct hsa-miR-1470:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 7.041E-5 3.152E-3 2.218E-2 4.485E-2 3 461
15 hsa-miR-3922-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.799E-5 3.152E-3 2.218E-2 4.968E-2 2 73
16 hsa-miR-6508-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.015E-5 3.152E-3 2.218E-2
5.106E-2
 2 74
17 hsa-miR-425*:mirSVR lowEffct hsa-miR-425*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.794E-5 3.152E-3 2.218E-2
5.602E-2
 3 497
18 hsa-miR-4717-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.908E-5 3.152E-3 2.218E-2
5.674E-2
 2 78
19 hsa-miR-148a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.058E-4 3.548E-3 2.496E-2
6.741E-2
 2 85
20 AAAGGAT,MIR-501:MSigDB AAAGGAT,MIR-501:MSigDB MSigDB 2.039E-4 6.106E-3 4.296E-2
1.299E-1
 2 118
21 hsa-miR-4726-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.074E-4 6.106E-3 4.296E-2
1.321E-1
 2 119
22 hsa-miR-4640-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.109E-4 6.106E-3 4.296E-2
1.343E-1
 2 120
23 hsa-miR-194-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.551E-4 7.064E-3 4.969E-2
1.625E-1
 2 132
24 hsa-miR-3173-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.668E-4 7.080E-3 4.981E-2
1.699E-1
 2 135
25 hsa-miR-6891-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.827E-4 7.204E-3
5.068E-2
1.801E-1
 2 139
26 hsa-miR-500a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.076E-4 7.536E-3
5.301E-2
1.959E-1
 2 145
27 hsa-miR-1231:PITA hsa-miR-1231:PITA TOP PITA 3.335E-4 7.867E-3
5.534E-2
2.124E-1
 2 151
28 hsa-miR-4325:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.468E-4 7.889E-3
5.550E-2
2.209E-1
 2 154
29 hsa-miR-5582-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.835E-4 8.149E-3
5.732E-2
2.443E-1
 2 162
30 hsa-miR-1252-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.883E-4 8.149E-3
5.732E-2
2.473E-1
 2 163
31 hsa-miR-549:PITA hsa-miR-549:PITA TOP PITA 4.075E-4 8.149E-3
5.732E-2
2.596E-1
 2 167
32 hsa-miR-365:PITA hsa-miR-365:PITA TOP PITA 4.123E-4 8.149E-3
5.732E-2
2.627E-1
 2 168
33 hsa-miR-149:PITA hsa-miR-149:PITA TOP PITA 4.221E-4 8.149E-3
5.732E-2
2.689E-1
 2 170
34 hsa-miR-6083:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.626E-4 8.513E-3
5.989E-2
2.947E-1
 2 178
35 hsa-miR-570-3p:Functional MTI Functional MTI miRTarbase 4.677E-4 8.513E-3
5.989E-2
2.979E-1
 2 179
36 hsa-miR-6894-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.156E-4 8.735E-3
6.145E-2
3.285E-1
 2 188
37 ACTGAAA,MIR-30E-3P:MSigDB ACTGAAA,MIR-30E-3P:MSigDB MSigDB 5.211E-4 8.735E-3
6.145E-2
3.319E-1
 2 189
38 ACTGAAA,MIR-30A-3P:MSigDB ACTGAAA,MIR-30A-3P:MSigDB MSigDB 5.211E-4 8.735E-3
6.145E-2
3.319E-1
 2 189
39 hsa-miR-516a-3p:PITA hsa-miR-516a-3p:PITA TOP PITA 6.545E-4 1.055E-2
7.423E-2
4.169E-1
 2 212
40 hsa-miR-576-3p:PITA hsa-miR-576-3p:PITA TOP PITA 6.668E-4 1.055E-2
7.423E-2
4.247E-1
 2 214
41 hsa-miR-369-5p:mirSVR lowEffct hsa-miR-369-5p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 6.792E-4 1.055E-2
7.423E-2
4.326E-1
 2 216
42 hsa-miR-654-3p:PITA hsa-miR-654-3p:PITA TOP PITA 6.980E-4 1.057E-2
7.434E-2
4.446E-1
 2 219
43 hsa-miR-892b:PITA hsa-miR-892b:PITA TOP PITA 7.171E-4 1.057E-2
7.434E-2
4.568E-1
 2 222
44 hsa-miR-499-5p:PITA hsa-miR-499-5p:PITA TOP PITA 7.300E-4 1.057E-2
7.434E-2
4.650E-1
 2 224
45 hsa-miR-1246:PITA hsa-miR-1246:PITA TOP PITA 7.892E-4 1.102E-2
7.754E-2
5.027E-1
 2 233
46 hsa-miR-1296:mirSVR highEffct hsa-miR-1296:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.959E-4 1.102E-2
7.754E-2
5.070E-1
 2 234
47 hsa-miR-371-5p:PITA hsa-miR-371-5p:PITA TOP PITA 8.577E-4 1.162E-2
8.178E-2
5.464E-1
 2 243
48 hsa-miR-582-3p:PITA hsa-miR-582-3p:PITA TOP PITA 9.656E-4 1.281E-2
9.015E-2
6.151E-1
 2 258
49 hsa-miR-205:PITA hsa-miR-205:PITA TOP PITA 1.135E-3 1.446E-2
1.017E-1
7.231E-1
 2 280
50 hsa-miR-889:PITA hsa-miR-889:PITA TOP PITA 1.135E-3 1.446E-2
1.017E-1
7.231E-1
 2 280
Show 45 more annotations

17: Drug [Display Chart] 13 input genes in category / 2141 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID005287709 AC1NRA5C Stitch 1.202E-14 2.573E-11 2.122E-10 2.573E-11 8 174
2 ctd:D013882 Thiosemicarbazones CTD 5.881E-6 6.296E-3
5.192E-2
 1.259E-2 3 64
3 CID000006199 psoralen Stitch 1.336E-5 9.536E-3
7.864E-2
 2.861E-2 3 84
4 CID000003165 NSC401575 Stitch 4.829E-5 2.168E-2
1.788E-1
1.034E-1
 3 129
5 CID000005543 triallate Stitch 5.086E-5 2.168E-2
1.788E-1
1.089E-1
 2 19
6 CID000065577 Topo Stitch 8.024E-5 2.168E-2
1.788E-1
1.718E-1
 3 153
7 CID000002354 diminazene Stitch 8.195E-5 2.168E-2
1.788E-1
1.755E-1
 2 24
8 CID000006278 1,1,1-trichloroethane Stitch 8.500E-5 2.168E-2
1.788E-1
1.820E-1
 3 156
9 ctd:D020148 Butyric Acid CTD 9.334E-5 2.168E-2
1.788E-1
1.998E-1
 3 161
10 CID000000776 histidinol Stitch 1.121E-4 2.168E-2
1.788E-1
2.400E-1
 2 28
11 CID003034155 reductone Stitch 1.289E-4 2.168E-2
1.788E-1
2.760E-1
 2 30
12 CID004604180 AC1NDNTH Stitch 1.320E-4 2.168E-2
1.788E-1
2.827E-1
 3 181
13 6220 DN Cycloheximide [66-81-9]; Down 200; 14.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.320E-4 2.168E-2
1.788E-1
2.827E-1
 3 181
14 CID000015074 isonicotinamide Stitch 1.563E-4 2.168E-2
1.788E-1
3.347E-1
 2 33
15 6902 DN 0297417-0002B [362658-29-5]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.670E-4 2.168E-2
1.788E-1
3.576E-1
 3 196
16 627 UP monastrol; Up 200; 100uM; MCF7; HG-U133A Broad Institute CMAP Up 1.670E-4 2.168E-2
1.788E-1
3.576E-1
 3 196
17 1885 DN Troleandomycin [2751-09-9]; Down 200; 5uM; PC3; HG-U133A Broad Institute CMAP Down 1.721E-4 2.168E-2
1.788E-1
3.685E-1
 3 198
18 CID000010549 2-(ethylsulfonyl)ethanol Stitch 2.047E-4 2.342E-2
1.931E-1
4.383E-1
 3 210
19 CID000030623 ICRF-187 Stitch 2.078E-4 2.342E-2
1.931E-1
4.449E-1
 2 38
20 CID000015325 DNTB Stitch 2.224E-4 2.349E-2
1.937E-1
4.762E-1
 3 216
21 ctd:C013813 4-anisidine CTD 2.304E-4 2.349E-2
1.937E-1
4.933E-1
 2 40
22 ctd:C005466 ursolic acid CTD 4.054E-4 2.901E-2
2.393E-1
8.679E-1
 2 53
23 ctd:C027185 indirubin CTD 4.689E-4 2.901E-2
2.393E-1
1.000E0
 2 57
24 CID000183113 AC1L4C9K Stitch 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
25 CID005288720 m3 8 Stitch 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
26 CID000079242 Z-hydrazine Stitch 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
27 CID000324535 NSC-290508 Stitch 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
28 CID005287652 norindenoisoquinoline Stitch 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
29 DB04690 Camptothecin Drug Bank 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
30 DB08691 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Drug Bank 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
31 CID000071645 mexenone Stitch 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
32 ctd:C053339 rebeccamycin CTD 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
33 ctd:C557741 1-(propoxymethyl)maleimide CTD 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
34 CID000008348 I--889 Stitch 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
35 ctd:C048396 NSC 354646 CTD 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
36 CID010456222 CHEBI:396030 Stitch 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
37 ctd:C038555 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin CTD 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
38 CID006440572 yuanhuadine Stitch 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
39 CID000481671 2-(4-hydroxyphenyl)ethyl heptadecanoate Stitch 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
40 DB08159 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE Drug Bank 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
41 DB07354 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM Drug Bank 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
42 DB05630 Sodium stibogluconate Drug Bank 5.692E-4 2.901E-2
2.393E-1
1.000E0
 1 1
43 CID000038347 4-HC Stitch 7.473E-4 3.384E-2
2.791E-1
1.000E0
 2 72
44 CID000469261 AC1LAIW3 Stitch 7.473E-4 3.384E-2
2.791E-1
1.000E0
 2 72
45 CID000065191 sulforhodamine B Stitch 7.681E-4 3.384E-2
2.791E-1
1.000E0
 2 73
46 CID004318740 AC1N8H7N Stitch 8.763E-4 3.384E-2
2.791E-1
1.000E0
 2 78
47 CID000003115 Stallimycin Stitch 9.216E-4 3.384E-2
2.791E-1
1.000E0
 2 80
48 CID000002538 NSC302991 Stitch 9.330E-4 3.384E-2
2.791E-1
1.000E0
 3 353
49 CID000001177 arabinosyluracil Stitch 9.406E-4 3.384E-2
2.791E-1
1.000E0
 3 354
50 CID000001896 AC1L1CH3 Stitch 1.039E-3 3.384E-2
2.791E-1
1.000E0
 2 85
Show 45 more annotations

18: Disease [Display Chart] 12 input genes in category / 288 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0002894 Refractory anaemia with excess blasts DisGeNET Curated 2.463E-4 3.087E-2
1.927E-1
7.093E-2
 2 32
2 C0149782 Squamous cell carcinoma of lung DisGeNET BeFree 3.808E-4 3.087E-2
1.927E-1
1.097E-1
 3 201
3 C2939461 Myeloid neoplasm DisGeNET BeFree 6.038E-4 3.087E-2
1.927E-1
1.739E-1
 2 50
4 C0443882 Anti-thyroid antibodies disorder DisGeNET BeFree 7.405E-4 3.087E-2
1.927E-1
2.133E-1
 1 1
5 cv:C0043119 Werner syndrome Clinical Variations 7.405E-4 3.087E-2
1.927E-1
2.133E-1
 1 1
6 C4023817 Aplasia/Hypoplasia of the testes DisGeNET Curated 7.405E-4 3.087E-2
1.927E-1
2.133E-1
 1 1
7 C0027022 Myeloproliferative disease DisGeNET Curated 7.540E-4 3.087E-2
1.927E-1
2.171E-1
 3 254
8 C0221013 Mastocytosis, Systemic DisGeNET Curated 1.114E-3 3.087E-2
1.927E-1
3.210E-1
 2 68
9 C0079772 T-Cell Lymphoma DisGeNET Curated 1.317E-3 3.087E-2
1.927E-1
3.793E-1
 3 308
10 C1335168 Ovarian Mucinous Tumor DisGeNET BeFree 1.481E-3 3.087E-2
1.927E-1
4.264E-1
 1 2
11 OMIN:277700 WERNER SYNDROME; WRN OMIM 1.481E-3 3.087E-2
1.927E-1
4.264E-1
 1 2
12 C0263625 Subcutaneous calcification DisGeNET Curated 1.481E-3 3.087E-2
1.927E-1
4.264E-1
 1 2
13 C1846574 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE, WITH AXONAL NEUROPATHY DisGeNET Curated 1.481E-3 3.087E-2
1.927E-1
4.264E-1
 1 2
14 C0020474 Hyperlipidemia, Familial Combined DisGeNET Curated 1.500E-3 3.087E-2
1.927E-1
4.321E-1
 2 79
15 C4275075 Atypical Werner syndrome DisGeNET Curated 2.220E-3 4.262E-2
2.661E-1
6.394E-1
 1 3
16 C0023480 Leukemia, Myelomonocytic, Chronic DisGeNET Curated 2.631E-3 4.485E-2
2.800E-1
7.577E-1
 2 105
17 C0233681 Grandiose delusions DisGeNET BeFree 2.959E-3 4.485E-2
2.800E-1
8.522E-1
 1 4
18 C2364016 Systemic sclerosis [scleroderma] DisGeNET BeFree 2.959E-3 4.485E-2
2.800E-1
8.522E-1
 1 4
19 C4275170 Autosomal recessive cerebellar ataxia with oculomotor apraxia type 1 DisGeNET BeFree 2.959E-3 4.485E-2
2.800E-1
8.522E-1
 1 4
20 C0349639 Juvenile Myelomonocytic Leukemia DisGeNET Curated 3.254E-3 4.630E-2
2.890E-1
9.370E-1
 2 117
21 C0013930 Embolism, Tumor DisGeNET BeFree 3.698E-3 4.630E-2
2.890E-1
1.000E0
 1 5
22 C3280303 Abnormal hair whorls DisGeNET Curated 3.698E-3 4.630E-2
2.890E-1
1.000E0
 1 5
23 C4280503 Premature hardening of arteries DisGeNET Curated 3.698E-3 4.630E-2
2.890E-1
1.000E0
 1 5
24 C1848486 Premature arteriosclerosis DisGeNET Curated 4.436E-3 4.929E-2
3.077E-1
1.000E0
 1 6
25 C0263491 Pili Torti DisGeNET Curated 4.436E-3 4.929E-2
3.077E-1
1.000E0
 1 6
26 C0376545 Hematologic Neoplasms DisGeNET Curated 4.600E-3 4.929E-2
3.077E-1
1.000E0
 3 478
27 C0018939 Hematological Disease DisGeNET Curated 4.621E-3 4.929E-2
3.077E-1
1.000E0
 2 140
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