Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc216_18, positive side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 18 input genes in category / 58 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016887 ATPase activity 4.549E-20 2.639E-18 1.226E-17 2.639E-18 14 446
2 GO:0042623 ATPase activity, coupled 1.120E-19 3.248E-18 1.509E-17 6.496E-18 13 332
3 GO:0036402 proteasome-activating ATPase activity 2.726E-15 5.270E-14 2.449E-13 1.581E-13 5 6
4 GO:0017025 TBP-class protein binding 1.514E-11 2.195E-10 1.020E-9 8.780E-10 5 23
5 GO:0033170 protein-DNA loading ATPase activity 7.610E-11 7.357E-10 3.418E-9 4.414E-9 4 9
6 GO:0003689 DNA clamp loader activity 7.610E-11 7.357E-10 3.418E-9 4.414E-9 4 9
7 GO:0008094 DNA-dependent ATPase activity 2.301E-10 1.907E-9 8.859E-9 1.335E-8 6 93
8 GO:0043142 single-stranded DNA-dependent ATPase activity 6.028E-10 4.370E-9 2.030E-8 3.496E-8 4 14
9 GO:0001094 TFIID-class transcription factor complex binding 1.840E-5 1.186E-4 5.510E-4 1.067E-3 2 7
10 GO:0001091 RNA polymerase II basal transcription factor binding 2.452E-5 1.422E-4 6.608E-4 1.422E-3 2 8
11 GO:0043141 ATP-dependent 5'-3' DNA helicase activity 1.046E-4 5.516E-4 2.563E-3 6.067E-3 2 16
12 GO:0043139 5'-3' DNA helicase activity 1.488E-4 7.193E-4 3.342E-3 8.631E-3 2 19
13 GO:0001098 basal transcription machinery binding 3.273E-4 1.356E-3 6.300E-3 1.898E-2 2 28
14 GO:0001099 basal RNA polymerase II transcription machinery binding 3.273E-4 1.356E-3 6.300E-3 1.898E-2 2 28
15 GO:0043531 ADP binding 7.047E-4 2.725E-3 1.266E-2 4.087E-2 2 41
16 GO:0004003 ATP-dependent DNA helicase activity 9.258E-4 3.291E-3 1.529E-2
5.370E-2
 2 47
17 GO:0031531 thyrotropin-releasing hormone receptor binding 9.646E-4 3.291E-3 1.529E-2
5.595E-2
 1 1
18 GO:0003678 DNA helicase activity 1.763E-3 5.682E-3 2.640E-2
1.023E-1
 2 65
19 GO:0051117 ATPase binding 3.132E-3 9.560E-3 4.442E-2
1.816E-1
 2 87
20 GO:0051082 unfolded protein binding 4.358E-3 1.264E-2
5.871E-2
2.527E-1
 2 103
21 GO:0070035 purine NTP-dependent helicase activity 5.130E-3 1.352E-2
6.284E-2
2.975E-1
 2 112
22 GO:0008026 ATP-dependent helicase activity 5.130E-3 1.352E-2
6.284E-2
2.975E-1
 2 112
23 GO:0001085 RNA polymerase II transcription factor binding 5.678E-3 1.395E-2
6.484E-2
3.293E-1
 2 118
24 GO:0061133 endopeptidase activator activity 5.774E-3 1.395E-2
6.484E-2
3.349E-1
 1 6
25 GO:0043140 ATP-dependent 3'-5' DNA helicase activity 6.734E-3 1.562E-2
7.258E-2
3.906E-1
 1 7
26 GO:0004176 ATP-dependent peptidase activity 9.606E-3 2.143E-2
9.957E-2
5.572E-1
 1 10
27 GO:0008568 microtubule-severing ATPase activity 1.056E-2 2.269E-2
1.054E-1
6.126E-1
 1 11
28 GO:0004386 helicase activity 1.173E-2 2.430E-2
1.129E-1
6.803E-1
 2 172
29 GO:0043138 3'-5' DNA helicase activity 1.247E-2 2.494E-2
1.159E-1
7.233E-1
 1 13
30 GO:0070628 proteasome binding 1.533E-2 2.963E-2
1.377E-1
8.890E-1
 1 16
31 GO:0051428 peptide hormone receptor binding 1.628E-2 3.046E-2
1.415E-1
9.442E-1
 1 17
Show 26 more annotations

2: GO: Biological Process [Display Chart] 18 input genes in category / 455 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 1.247E-13 2.945E-11 1.972E-10 5.672E-11 7 64
2 GO:0006521 regulation of cellular amino acid metabolic process 1.561E-13 2.945E-11 1.972E-10 7.104E-11 7 66
3 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 1.941E-13 2.945E-11 1.972E-10 8.834E-11 7 68
4 GO:1904667 negative regulation of ubiquitin protein ligase activity 3.255E-13 3.296E-11 2.208E-10 1.481E-10 7 73
5 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly 3.622E-13 3.296E-11 2.208E-10 1.648E-10 5 12
6 GO:0031145 anaphase-promoting complex-dependent catabolic process 4.794E-13 3.635E-11 2.435E-10 2.181E-10 7 77
7 GO:0051444 negative regulation of ubiquitin-protein transferase activity 6.917E-13 3.934E-11 2.635E-10 3.147E-10 7 81
8 GO:1904668 positive regulation of ubiquitin protein ligase activity 6.917E-13 3.934E-11 2.635E-10 3.147E-10 7 81
9 GO:0051352 negative regulation of ligase activity 8.251E-13 4.171E-11 2.794E-10 3.754E-10 7 83
10 GO:1904666 regulation of ubiquitin protein ligase activity 9.798E-13 4.458E-11 2.986E-10 4.458E-10 7 85
11 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly 1.371E-12 5.671E-11 3.799E-10 6.239E-10 5 15
12 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 1.733E-12 6.570E-11 4.401E-10 7.884E-10 7 92
13 GO:0033238 regulation of cellular amine metabolic process 2.022E-12 6.573E-11 4.403E-10 9.202E-10 7 94
14 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 2.022E-12 6.573E-11 4.403E-10 9.202E-10 7 94
15 GO:0051443 positive regulation of ubiquitin-protein transferase activity 3.897E-12 1.108E-10 7.423E-10 1.773E-9 7 103
16 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 3.897E-12 1.108E-10 7.423E-10 1.773E-9 7 103
17 GO:0002223 stimulatory C-type lectin receptor signaling pathway 4.176E-12 1.118E-10 7.486E-10 1.900E-9 7 104
18 GO:0002220 innate immune response activating cell surface receptor signaling pathway 5.118E-12 1.268E-10 8.497E-10 2.328E-9 7 107
19 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 5.297E-12 1.268E-10 8.497E-10 2.410E-9 5 19
20 GO:0051351 positive regulation of ligase activity 5.842E-12 1.329E-10 8.902E-10 2.658E-9 7 109
21 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 7.556E-12 1.637E-10 1.097E-9 3.438E-9 7 113
22 GO:0090175 regulation of establishment of planar polarity 8.046E-12 1.664E-10 1.115E-9 3.661E-9 7 114
23 GO:0038061 NIK/NF-kappaB signaling 1.093E-11 2.161E-10 1.448E-9 4.971E-9 7 119
24 GO:0051438 regulation of ubiquitin-protein transferase activity 1.160E-11 2.198E-10 1.473E-9 5.276E-9 7 120
25 GO:0051340 regulation of ligase activity 1.382E-11 2.516E-10 1.685E-9 6.290E-9 7 123
26 GO:0090263 positive regulation of canonical Wnt signaling pathway 1.464E-11 2.563E-10 1.717E-9 6.663E-9 7 124
27 GO:0001736 establishment of planar polarity 1.641E-11 2.765E-10 1.852E-9 7.465E-9 7 126
28 GO:0007164 establishment of tissue polarity 1.736E-11 2.820E-10 1.889E-9 7.897E-9 7 127
29 GO:0051123 RNA polymerase II preinitiation complex assembly 1.931E-11 3.029E-10 2.029E-9 8.784E-9 5 24
30 GO:1900262 regulation of DNA-directed DNA polymerase activity 2.134E-11 3.132E-10 2.098E-9 9.709E-9 4 7
31 GO:1900264 positive regulation of DNA-directed DNA polymerase activity 2.134E-11 3.132E-10 2.098E-9 9.709E-9 4 7
32 GO:0045862 positive regulation of proteolysis 2.362E-11 3.227E-10 2.162E-9 1.075E-8 9 381
33 GO:0031397 negative regulation of protein ubiquitination 2.409E-11 3.227E-10 2.162E-9 1.096E-8 7 133
34 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 2.412E-11 3.227E-10 2.162E-9 1.097E-8 5 25
35 GO:2000144 positive regulation of DNA-templated transcription, initiation 2.984E-11 3.772E-10 2.527E-9 1.358E-8 5 26
36 GO:0070897 transcription preinitiation complex assembly 2.984E-11 3.772E-10 2.527E-9 1.358E-8 5 26
37 GO:0001738 morphogenesis of a polarized epithelium 3.644E-11 4.481E-10 3.002E-9 1.658E-8 7 141
38 GO:0038095 Fc-epsilon receptor signaling pathway 3.831E-11 4.587E-10 3.073E-9 1.743E-8 7 142
39 GO:1903321 negative regulation of protein modification by small protein conjugation or removal 4.026E-11 4.697E-10 3.146E-9 1.832E-8 7 143
40 GO:0043488 regulation of mRNA stability 4.229E-11 4.811E-10 3.223E-9 1.924E-8 7 144
41 GO:0043487 regulation of RNA stability 5.134E-11 5.697E-10 3.816E-9 2.336E-8 7 148
42 GO:0033209 tumor necrosis factor-mediated signaling pathway 7.115E-11 7.708E-10 5.164E-9 3.238E-8 7 155
43 GO:0030177 positive regulation of Wnt signaling pathway 8.146E-11 8.620E-10 5.774E-9 3.706E-8 7 158
44 GO:0035567 non-canonical Wnt signaling pathway 8.517E-11 8.807E-10 5.900E-9 3.875E-8 7 159
45 GO:2000142 regulation of DNA-templated transcription, initiation 1.072E-10 1.084E-9 7.263E-9 4.879E-8 5 33
46 GO:0090090 negative regulation of canonical Wnt signaling pathway 1.106E-10 1.094E-9 7.327E-9 5.031E-8 7 165
47 GO:0002478 antigen processing and presentation of exogenous peptide antigen 1.154E-10 1.117E-9 7.483E-9 5.250E-8 7 166
48 GO:0019884 antigen processing and presentation of exogenous antigen 1.543E-10 1.463E-9 9.799E-9 7.022E-8 7 173
49 GO:0050852 T cell receptor signaling pathway 1.673E-10 1.554E-9 1.041E-8 7.613E-8 7 175
50 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 2.040E-10 1.856E-9 1.243E-8 9.280E-8 7 180
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 18 input genes in category / 76 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008540 proteasome regulatory particle, base subcomplex 1.388E-19 1.055E-17 5.183E-17 1.055E-17 7 12
2 GO:0005838 proteasome regulatory particle 2.028E-17 7.707E-16 3.787E-15 1.541E-15 7 21
3 GO:0022624 proteasome accessory complex 6.027E-17 1.527E-15 7.504E-15 4.581E-15 7 24
4 GO:0031597 cytosolic proteasome complex 2.569E-16 4.881E-15 2.399E-14 1.952E-14 6 12
5 GO:0000502 proteasome complex 2.301E-15 3.498E-14 1.719E-13 1.749E-13 8 78
6 GO:0031595 nuclear proteasome complex 2.286E-14 2.895E-13 1.423E-12 1.737E-12 5 8
7 GO:0031390 Ctf18 RFC-like complex 1.944E-11 2.111E-10 1.037E-9 1.478E-9 4 7
8 GO:0005663 DNA replication factor C complex 1.412E-8 1.341E-7 6.591E-7 1.073E-6 3 6
9 GO:0044445 cytosolic part 5.404E-8 4.563E-7 2.243E-6 4.107E-6 6 235
10 GO:0097255 R2TP complex 8.409E-6 6.391E-5 3.141E-4 6.391E-4 2 5
11 GO:0000812 Swr1 complex 3.020E-5 2.066E-4 1.015E-3 2.295E-3 2 9
12 GO:0005657 replication fork 3.262E-5 2.066E-4 1.015E-3 2.479E-3 3 67
13 GO:0031011 Ino80 complex 7.613E-5 4.451E-4 2.187E-3 5.786E-3 2 14
14 GO:0033202 DNA helicase complex 8.780E-5 4.766E-4 2.342E-3 6.673E-3 2 15
15 GO:1902562 H4 histone acetyltransferase complex 1.427E-4 6.378E-4 3.134E-3 1.084E-2 2 19
16 GO:0043189 H4/H2A histone acetyltransferase complex 1.427E-4 6.378E-4 3.134E-3 1.084E-2 2 19
17 GO:0035267 NuA4 histone acetyltransferase complex 1.427E-4 6.378E-4 3.134E-3 1.084E-2 2 19
18 GO:0097346 INO80-type complex 1.750E-4 7.389E-4 3.631E-3 1.330E-2 2 21
19 GO:0071339 MLL1 complex 3.138E-4 1.192E-3 5.860E-3 2.385E-2 2 28
20 GO:0044665 MLL1/2 complex 3.138E-4 1.192E-3 5.860E-3 2.385E-2 2 28
21 GO:0005745 m-AAA complex 1.888E-3 6.388E-3 3.139E-2
1.435E-1
 1 2
22 GO:0034515 proteasome storage granule 1.888E-3 6.388E-3 3.139E-2
1.435E-1
 1 2
23 GO:0000932 P-body 2.070E-3 6.388E-3 3.139E-2
1.573E-1
 2 72
24 GO:0035097 histone methyltransferase complex 2.127E-3 6.388E-3 3.139E-2
1.617E-1
 2 73
25 GO:0016234 inclusion body 2.185E-3 6.388E-3 3.139E-2
1.661E-1
 2 74
26 GO:0070603 SWI/SNF superfamily-type complex 2.185E-3 6.388E-3 3.139E-2
1.661E-1
 2 74
27 GO:0000123 histone acetyltransferase complex 3.142E-3 8.843E-3 4.346E-2
2.388E-1
 2 89
28 GO:0034708 methyltransferase complex 3.353E-3 9.100E-3 4.472E-2
2.548E-1
 2 92
29 GO:1902493 acetyltransferase complex 3.947E-3 9.999E-3 4.914E-2
3.000E-1
 2 100
30 GO:0031248 protein acetyltransferase complex 3.947E-3 9.999E-3 4.914E-2
3.000E-1
 2 100
31 GO:0016363 nuclear matrix 4.342E-3 1.064E-2
5.231E-2
3.300E-1
 2 105
32 GO:0034399 nuclear periphery 7.073E-3 1.680E-2
8.255E-2
5.375E-1
 2 135
33 GO:0036464 cytoplasmic ribonucleoprotein granule 8.011E-3 1.845E-2
9.067E-2
6.088E-1
 2 144
34 GO:0090543 Flemming body 8.469E-3 1.893E-2
9.303E-2
6.436E-1
 1 9
35 GO:0035770 ribonucleoprotein granule 8.889E-3 1.930E-2
9.486E-2
6.756E-1
 2 152
36 GO:0000815 ESCRT III complex 1.034E-2 2.183E-2
1.073E-1
7.860E-1
 1 11
37 GO:0005675 transcription factor TFIIH holo complex 1.221E-2 2.508E-2
1.233E-1
9.280E-1
 1 13
38 GO:0001673 male germ cell nucleus 1.966E-2 3.931E-2
1.932E-1
1.000E0
 1 21
39 GO:0032806 carboxy-terminal domain protein kinase complex 2.151E-2 4.191E-2
2.060E-1
1.000E0
 1 23
40 GO:0031305 integral component of mitochondrial inner membrane 2.428E-2 4.455E-2
2.189E-1
1.000E0
 1 26
41 GO:0036452 ESCRT complex 2.428E-2 4.455E-2
2.189E-1
1.000E0
 1 26
42 GO:0031304 intrinsic component of mitochondrial inner membrane 2.520E-2 4.455E-2
2.189E-1
1.000E0
 1 27
43 GO:0043073 germ cell nucleus 2.520E-2 4.455E-2
2.189E-1
1.000E0
 1 27
44 GO:0005719 nuclear euchromatin 2.797E-2 4.831E-2
2.374E-1
1.000E0
 1 30
Show 39 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 620 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 15 input genes in category / 295 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 18 input genes in category / 58 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00004 AAA Pfam 3.889E-37 2.177E-35 1.012E-34 2.255E-35 15 52
2 IPR003959 ATPase AAA core InterPro 7.508E-37 2.177E-35 1.012E-34 4.354E-35 15 54
3 IPR003593 AAA+ ATPase InterPro 7.302E-30 1.059E-28 4.919E-28 4.235E-28 15 144
4 SM00382 AAA SMART 7.302E-30 1.059E-28 4.919E-28 4.235E-28 15 144
5 IPR003960 ATPase AAA CS InterPro 6.172E-22 7.159E-21 3.326E-20 3.580E-20 9 29
6 PS00674 AAA PROSITE 3.225E-21 3.118E-20 1.449E-19 1.871E-19 9 34
7 IPR005937 26S Psome P45 InterPro 2.673E-15 2.214E-14 1.029E-13 1.550E-13 5 6
8 IPR008921 DNA pol3 clamp-load cplx C InterPro 8.934E-12 6.477E-11 3.009E-10 5.182E-10 4 6
9 IPR013748 Rep factorC C InterPro 7.446E-10 4.319E-9 2.007E-8 4.319E-8 3 3
10 PF08542 Rep fac C Pfam 7.446E-10 4.319E-9 2.007E-8 4.319E-8 3 3
11 IPR010339 TIP49 C InterPro 8.718E-7 3.890E-6 1.807E-5 5.057E-5 2 2
12 IPR027238 RuvB-like InterPro 8.718E-7 3.890E-6 1.807E-5 5.057E-5 2 2
13 PF06068 TIP49 Pfam 8.718E-7 3.890E-6 1.807E-5 5.057E-5 2 2
14 IPR001270 ClpA/B InterPro 1.826E-5 7.563E-5 3.514E-4 1.059E-3 2 7
15 PF12002 MgsA C Pfam 9.608E-4 2.229E-3 1.036E-2
5.572E-2
 1 1
16 PF16193 AAA assoc 2 Pfam 9.608E-4 2.229E-3 1.036E-2
5.572E-2
 1 1
17 IPR016643 26S Psome Rpn1 InterPro 9.608E-4 2.229E-3 1.036E-2
5.572E-2
 1 1
18 IPR027040 Proteasome su Rpn10 InterPro 9.608E-4 2.229E-3 1.036E-2
5.572E-2
 1 1
19 IPR031255 VPS4A InterPro 9.608E-4 2.229E-3 1.036E-2
5.572E-2
 1 1
20 PF04683 Proteasom Rpn13 Pfam 9.608E-4 2.229E-3 1.036E-2
5.572E-2
 1 1
21 IPR032423 AAA assoc 2 InterPro 9.608E-4 2.229E-3 1.036E-2
5.572E-2
 1 1
22 PF16550 RPN13 C Pfam 9.608E-4 2.229E-3 1.036E-2
5.572E-2
 1 1
23 IPR032368 RPN13 C InterPro 9.608E-4 2.229E-3 1.036E-2
5.572E-2
 1 1
24 IPR021886 MgsA C InterPro 9.608E-4 2.229E-3 1.036E-2
5.572E-2
 1 1
25 IPR006773 26S Psome Ubiquitin-recp Rpn13 InterPro 9.608E-4 2.229E-3 1.036E-2
5.572E-2
 1 1
26 IPR011546 Pept M41 FtsH extracell InterPro 1.921E-3 4.126E-3 1.917E-2
1.114E-1
 1 2
27 PF06480 FtsH ext Pfam 1.921E-3 4.126E-3 1.917E-2
1.114E-1
 1 2
28 IPR002015 Proteasome/cyclosome rpt InterPro 2.880E-3 4.912E-3 2.282E-2
1.670E-1
 1 3
29 PF04056 Ssl1 Pfam 2.880E-3 4.912E-3 2.282E-2
1.670E-1
 1 3
30 IPR007198 Ssl1-like InterPro 2.880E-3 4.912E-3 2.282E-2
1.670E-1
 1 3
31 IPR005936 FtsH InterPro 2.880E-3 4.912E-3 2.282E-2
1.670E-1
 1 3
32 IPR000642 Peptidase M41 InterPro 2.880E-3 4.912E-3 2.282E-2
1.670E-1
 1 3
33 PF01851 PC rep Pfam 2.880E-3 4.912E-3 2.282E-2
1.670E-1
 1 3
34 PF01434 Peptidase M41 Pfam 2.880E-3 4.912E-3 2.282E-2
1.670E-1
 1 3
35 PF13519 VWA 2 Pfam 4.795E-3 7.517E-3 3.492E-2
2.781E-1
 1 5
36 IPR006642 Znf Rad18 put InterPro 4.795E-3 7.517E-3 3.492E-2
2.781E-1
 1 5
37 SM00734 ZnF Rad18 SMART 4.795E-3 7.517E-3 3.492E-2
2.781E-1
 1 5
38 IPR015415 Vps4 C InterPro 7.662E-3 1.139E-2
5.294E-2
4.444E-1
 1 8
39 PF09336 Vps4 C Pfam 7.662E-3 1.139E-2
5.294E-2
4.444E-1
 1 8
40 IPR008949 Isoprenoid synthase dom InterPro 8.616E-3 1.249E-2
5.804E-2
4.997E-1
 1 9
41 PF04212 MIT Pfam 9.569E-3 1.321E-2
6.139E-2
5.550E-1
 1 10
42 SM00745 MIT SMART 9.569E-3 1.321E-2
6.139E-2
5.550E-1
 1 10
43 1.20.58.280 - Gene3D 1.242E-2 1.676E-2
7.785E-2
7.205E-1
 1 13
44 IPR007330 MIT InterPro 1.337E-2 1.763E-2
8.190E-2
7.756E-1
 1 14
45 PF02809 UIM Pfam 1.716E-2 2.212E-2
1.028E-1
9.953E-1
 1 18
46 SM00726 UIM SMART 1.999E-2 2.521E-2
1.171E-1
1.000E0
 1 21
47 PS50330 UIM PROSITE 2.282E-2 2.756E-2
1.281E-1
1.000E0
 1 24
48 IPR010978 tRNA-bd arm InterPro 2.282E-2 2.756E-2
1.281E-1
1.000E0
 1 24
49 IPR011072 HR1 rho-bd InterPro 2.376E-2 2.756E-2
1.281E-1
1.000E0
 1 25
50 IPR003903 UIM dom InterPro 2.376E-2 2.756E-2
1.281E-1
1.000E0
 1 25
Show 45 more annotations

7: Pathway [Display Chart] 14 input genes in category / 222 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269779 Synthesis of DNA BioSystems: REACTOME 9.354E-19 2.076E-16 1.242E-15 2.076E-16 10 103
2 1269875 DNA Replication BioSystems: REACTOME 2.039E-18 2.263E-16 1.354E-15 4.526E-16 10 111
3 1269777 S Phase BioSystems: REACTOME 1.227E-17 9.078E-16 5.431E-15 2.723E-15 10 132
4 83040 Proteasome BioSystems: KEGG 4.460E-17 2.475E-15 1.481E-14 9.902E-15 8 45
5 1269753 G2/M Checkpoints BioSystems: REACTOME 1.858E-16 8.251E-15 4.936E-14 4.126E-14 10 172
6 1427861 UCH proteinases BioSystems: REACTOME 3.508E-16 1.298E-14 7.764E-14 7.788E-14 9 107
7 1269742 Cell Cycle Checkpoints BioSystems: REACTOME 1.058E-15 3.355E-14 2.007E-13 2.349E-13 10 204
8 1269199 Cross-presentation of soluble exogenous antigens (endosomes) BioSystems: REACTOME 5.631E-14 9.885E-13 5.913E-12 1.250E-11 7 53
9 1270296 Regulation of activated PAK-2p34 by proteasome mediated degradation BioSystems: REACTOME 5.631E-14 9.885E-13 5.913E-12 1.250E-11 7 53
10 1269792 Ubiquitin-dependent degradation of Cyclin D1 BioSystems: REACTOME 6.467E-14 9.885E-13 5.913E-12 1.436E-11 7 54
11 1270174 Regulation of ornithine decarboxylase (ODC) BioSystems: REACTOME 6.467E-14 9.885E-13 5.913E-12 1.436E-11 7 54
12 1269791 Ubiquitin-dependent degradation of Cyclin D BioSystems: REACTOME 6.467E-14 9.885E-13 5.913E-12 1.436E-11 7 54
13 1269783 CDK-mediated phosphorylation and removal of Cdc6 BioSystems: REACTOME 6.467E-14 9.885E-13 5.913E-12 1.436E-11 7 54
14 1269107 Vpu mediated degradation of CD4 BioSystems: REACTOME 7.406E-14 9.885E-13 5.913E-12 1.644E-11 7 55
15 1269747 Autodegradation of the E3 ubiquitin ligase COP1 BioSystems: REACTOME 7.406E-14 9.885E-13 5.913E-12 1.644E-11 7 55
16 1269752 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A BioSystems: REACTOME 8.460E-14 9.885E-13 5.913E-12 1.878E-11 7 56
17 1269751 p53-Independent DNA Damage Response BioSystems: REACTOME 8.460E-14 9.885E-13 5.913E-12 1.878E-11 7 56
18 1269750 p53-Independent G1/S DNA damage checkpoint BioSystems: REACTOME 8.460E-14 9.885E-13 5.913E-12 1.878E-11 7 56
19 1270295 Regulation of Apoptosis BioSystems: REACTOME 8.460E-14 9.885E-13 5.913E-12 1.878E-11 7 56
20 1269098 Vif-mediated degradation of APOBEC3G BioSystems: REACTOME 9.640E-14 1.014E-12 6.063E-12 2.140E-11 7 57
21 1269606 Degradation of AXIN BioSystems: REACTOME 1.096E-13 1.014E-12 6.063E-12 2.432E-11 7 58
22 1269746 Stabilization of p53 BioSystems: REACTOME 1.096E-13 1.014E-12 6.063E-12 2.432E-11 7 58
23 1269841 SCF-beta-TrCP mediated degradation of Emi1 BioSystems: REACTOME 1.096E-13 1.014E-12 6.063E-12 2.432E-11 7 58
24 1457807 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis BioSystems: REACTOME 1.096E-13 1.014E-12 6.063E-12 2.432E-11 7 58
25 1269726 AUF1 (hnRNP D0) binds and destabilizes mRNA BioSystems: REACTOME 1.243E-13 1.103E-12 6.601E-12 2.759E-11 7 59
26 1268928 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD BioSystems: REACTOME 1.406E-13 1.201E-12 7.182E-12 3.121E-11 7 60
27 1269605 Degradation of DVL BioSystems: REACTOME 1.588E-13 1.276E-12 7.631E-12 3.524E-11 7 61
28 1269836 CDT1 association with the CDC6:ORC:origin complex BioSystems: REACTOME 1.789E-13 1.276E-12 7.631E-12 3.971E-11 7 62
29 1268927 Hh mutants abrogate ligand secretion BioSystems: REACTOME 1.789E-13 1.276E-12 7.631E-12 3.971E-11 7 62
30 1269331 NIK-->noncanonical NF-kB signaling BioSystems: REACTOME 1.789E-13 1.276E-12 7.631E-12 3.971E-11 7 62
31 1383017 The role of GTSE1 in G2/M progression after G2 checkpoint BioSystems: REACTOME 2.011E-13 1.276E-12 7.631E-12 4.465E-11 7 63
32 1269306 Dectin-1 mediated noncanonical NF-kB signaling BioSystems: REACTOME 2.011E-13 1.276E-12 7.631E-12 4.465E-11 7 63
33 1269637 GLI3 is processed to GLI3R by the proteasome BioSystems: REACTOME 2.011E-13 1.276E-12 7.631E-12 4.465E-11 7 63
34 1269638 Degradation of GLI2 by the proteasome BioSystems: REACTOME 2.011E-13 1.276E-12 7.631E-12 4.465E-11 7 63
35 1269770 SCF(Skp2)-mediated degradation of p27/p21 BioSystems: REACTOME 2.011E-13 1.276E-12 7.631E-12 4.465E-11 7 63
36 1268934 Defective CFTR causes cystic fibrosis BioSystems: REACTOME 2.257E-13 1.354E-12 8.102E-12 5.011E-11 7 64
37 1269639 Degradation of GLI1 by the proteasome BioSystems: REACTOME 2.257E-13 1.354E-12 8.102E-12 5.011E-11 7 64
38 1269852 Autodegradation of Cdh1 by Cdh1:APC/C BioSystems: REACTOME 2.827E-13 1.651E-12 9.879E-12 6.276E-11 7 66
39 1269744 p53-Dependent G1/S DNA damage checkpoint BioSystems: REACTOME 3.155E-13 1.751E-12 1.048E-11 7.004E-11 7 67
40 1269745 p53-Dependent G1 DNA Damage Response BioSystems: REACTOME 3.155E-13 1.751E-12 1.048E-11 7.004E-11 7 67
41 1427862 Ub-specific processing proteases BioSystems: REACTOME 3.245E-13 1.757E-12 1.051E-11 7.205E-11 9 225
42 1269634 Hedgehog ligand biogenesis BioSystems: REACTOME 3.910E-13 1.929E-12 1.154E-11 8.681E-11 7 69
43 1269612 Asymmetric localization of PCP proteins BioSystems: REACTOME 3.910E-13 1.929E-12 1.154E-11 8.681E-11 7 69
44 1270418 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha BioSystems: REACTOME 3.910E-13 1.929E-12 1.154E-11 8.681E-11 7 69
45 1269743 G1/S DNA Damage Checkpoints BioSystems: REACTOME 3.910E-13 1.929E-12 1.154E-11 8.681E-11 7 69
46 1269849 APC/C:Cdc20 mediated degradation of Securin BioSystems: REACTOME 4.343E-13 2.051E-12 1.227E-11 9.641E-11 7 70
47 1269186 Activation of NF-kappaB in B cells BioSystems: REACTOME 4.343E-13 2.051E-12 1.227E-11 9.641E-11 7 70
48 1269833 Assembly of the pre-replicative complex BioSystems: REACTOME 4.815E-13 2.182E-12 1.305E-11 1.069E-10 7 71
49 1268933 ABC transporter disorders BioSystems: REACTOME 4.815E-13 2.182E-12 1.305E-11 1.069E-10 7 71
50 1269778 Cyclin A:Cdk2-associated events at S phase entry BioSystems: REACTOME 5.894E-13 2.566E-12 1.535E-11 1.308E-10 7 73
Show 45 more annotations

8: Pubmed [Display Chart] 18 input genes in category / 1121 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18922472 Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Pubmed 7.628E-26 8.551E-23 6.498E-22 8.551E-23 10 45
2 19490896 Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. Pubmed 2.940E-23 1.648E-20 1.252E-19 3.296E-20 8 19
3 20810900 Parkin directly modulates 26S proteasome activity. Pubmed 4.871E-23 1.820E-20 1.383E-19 5.460E-20 7 9
4 17573772 Anchoring of the 26S proteasome to the organellar membrane by FKBP38. Pubmed 4.079E-21 1.143E-18 8.687E-18 4.572E-18 8 32
5 27428775 An atomic structure of the human 26S proteasome. Pubmed 7.038E-21 1.578E-18 1.199E-17 7.889E-18 8 34
6 17323924 Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Pubmed 1.009E-19 1.615E-17 1.227E-16 1.131E-16 8 46
7 28821611 The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress. Pubmed 1.009E-19 1.615E-17 1.227E-16 1.131E-16 8 46
8 21628461 C termini of proteasomal ATPases play nonequivalent roles in cellular assembly of mammalian 26 S proteasome. Pubmed 1.206E-19 1.689E-17 1.284E-16 1.351E-16 6 8
9 28292943 Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome. Pubmed 2.458E-19 3.062E-17 2.327E-16 2.756E-16 8 51
10 19013454 Isolation of human proteasomes and putative proteasome-interacting proteins using a novel affinity chromatography method. Pubmed 7.388E-19 8.282E-17 6.294E-16 8.282E-16 8 58
11 19193609 Affinity purification strategy to capture human endogenous proteasome complexes diversity and to identify proteasome-interacting proteins. Pubmed 1.491E-18 1.520E-16 1.155E-15 1.671E-15 8 63
12 22275368 Stable incorporation of ATPase subunits into 19 S regulatory particle of human proteasome requires nucleotide binding and C-terminal tails. Pubmed 1.988E-18 1.857E-16 1.411E-15 2.228E-15 6 11
13 15610744 Proteasome involvement in the repair of DNA double-strand breaks. Pubmed 3.974E-18 3.274E-16 2.488E-15 4.455E-15 6 12
14 23503661 Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Pubmed 4.088E-18 3.274E-16 2.488E-15 4.583E-15 8 71
15 16857966 Mapping the murine cardiac 26S proteasome complexes. Pubmed 9.039E-18 6.755E-16 5.134E-15 1.013E-14 7 35
16 10893419 Degradation of HIV-1 integrase by the N-end rule pathway. Pubmed 3.018E-17 1.346E-15 1.023E-14 3.383E-14 7 41
17 12419264 The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing. Pubmed 3.018E-17 1.346E-15 1.023E-14 3.383E-14 7 41
18 14550573 Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. Pubmed 3.018E-17 1.346E-15 1.023E-14 3.383E-14 7 41
19 9079628 HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation. Pubmed 3.018E-17 1.346E-15 1.023E-14 3.383E-14 7 41
20 12920286 Virology. Weapons of mutational destruction. Pubmed 3.620E-17 1.346E-15 1.023E-14 4.058E-14 7 42
21 12719574 Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions. Pubmed 3.620E-17 1.346E-15 1.023E-14 4.058E-14 7 42
22 12750511 Hypermutation of HIV-1 DNA in the absence of the Vif protein. Pubmed 3.620E-17 1.346E-15 1.023E-14 4.058E-14 7 42
23 12914693 Death by deamination: a novel host restriction system for HIV-1. Pubmed 3.620E-17 1.346E-15 1.023E-14 4.058E-14 7 42
24 12840737 Good to CU. Pubmed 3.620E-17 1.346E-15 1.023E-14 4.058E-14 7 42
25 12830140 DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses. Pubmed 3.620E-17 1.346E-15 1.023E-14 4.058E-14 7 42
26 9811770 An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. Pubmed 3.620E-17 1.346E-15 1.023E-14 4.058E-14 7 42
27 14614829 The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G. Pubmed 3.620E-17 1.346E-15 1.023E-14 4.058E-14 7 42
28 9846577 Evidence for a newly discovered cellular anti-HIV-1 phenotype. Pubmed 3.620E-17 1.346E-15 1.023E-14 4.058E-14 7 42
29 12970355 The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity. Pubmed 4.323E-17 1.346E-15 1.023E-14 4.846E-14 7 43
30 12808466 Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Pubmed 4.323E-17 1.346E-15 1.023E-14 4.846E-14 7 43
31 12808465 The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. Pubmed 4.323E-17 1.346E-15 1.023E-14 4.846E-14 7 43
32 14528300 The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. Pubmed 4.323E-17 1.346E-15 1.023E-14 4.846E-14 7 43
33 14557625 The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity. Pubmed 4.323E-17 1.346E-15 1.023E-14 4.846E-14 7 43
34 14528301 HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. Pubmed 4.323E-17 1.346E-15 1.023E-14 4.846E-14 7 43
35 14527406 HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. Pubmed 4.323E-17 1.346E-15 1.023E-14 4.846E-14 7 43
36 12809610 DNA deamination mediates innate immunity to retroviral infection. Pubmed 4.323E-17 1.346E-15 1.023E-14 4.846E-14 7 43
37 12167863 Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Pubmed 5.139E-17 1.557E-15 1.183E-14 5.761E-14 7 44
38 22901813 Cancer vulnerabilities unveiled by genomic loss. Pubmed 7.591E-17 2.127E-15 1.617E-14 8.509E-14 5 6
39 9473509 Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. Pubmed 7.591E-17 2.127E-15 1.617E-14 8.509E-14 5 6
40 20843792 ASK1 negatively regulates the 26 S proteasome. Pubmed 7.591E-17 2.127E-15 1.617E-14 8.509E-14 5 6
41 14564014 Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. Pubmed 9.865E-17 2.697E-15 2.050E-14 1.106E-13 7 48
42 12859895 Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. Pubmed 1.151E-16 3.071E-15 2.334E-14 1.290E-13 7 49
43 20473970 Identification of FBXO25-interacting proteins using an integrated proteomics approach. Pubmed 1.810E-16 4.718E-15 3.586E-14 2.029E-13 8 112
44 17314511 Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Pubmed 1.880E-16 4.790E-15 3.640E-14 2.107E-13 9 211
45 12791267 Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Pubmed 2.714E-16 6.761E-15 5.138E-14 3.042E-13 7 55
46 22645313 Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. Pubmed 4.018E-16 9.793E-15 7.442E-14 4.505E-13 7 58
47 15029244 Mammalian Cdh1/Fzr mediates its own degradation. Pubmed 4.558E-16 1.087E-14 8.262E-14 5.110E-13 7 59
48 25147182 Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. Pubmed 4.952E-16 1.157E-14 8.789E-14 5.551E-13 10 394
49 28539385 Phosphatase UBLCP1 controls proteasome assembly. Pubmed 5.770E-16 1.320E-14 1.003E-13 6.468E-13 6 24
50 21589869 RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Pubmed 6.555E-16 1.470E-14 1.117E-13 7.348E-13 8 131
Show 45 more annotations

9: Interaction [Display Chart] 18 input genes in category / 1262 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CCDC74B CCDC74B interactions 1.964E-19 2.479E-16 1.913E-15 2.479E-16 8 25
2 int:CCDC92 CCDC92 interactions 4.253E-18 2.684E-15 2.071E-14 5.368E-15 8 35
3 int:PSMC6 PSMC6 interactions 4.105E-17 1.727E-14 1.333E-13 5.181E-14 10 145
4 int:PSMB8 PSMB8 interactions 5.253E-16 1.657E-13 1.279E-12 6.629E-13 8 61
5 int:PRKN PRKN interactions 1.360E-15 3.434E-13 2.650E-12 1.717E-12 12 461
6 int:PSMC3 PSMC3 interactions 2.385E-15 4.366E-13 3.369E-12 3.009E-12 10 216
7 int:UBLCP1 UBLCP1 interactions 2.421E-15 4.366E-13 3.369E-12 3.056E-12 7 36
8 int:UCHL5 UCHL5 interactions 3.604E-15 5.686E-13 4.388E-12 4.549E-12 10 225
9 int:PSMD12 PSMD12 interactions 5.895E-15 7.938E-13 6.127E-12 7.439E-12 9 145
10 int:PSMD10 PSMD10 interactions 6.290E-15 7.938E-13 6.127E-12 7.938E-12 8 82
11 int:PSMD5 PSMD5 interactions 7.686E-15 8.203E-13 6.331E-12 9.700E-12 8 84
12 int:PAAF1 PAAF1 interactions 7.800E-15 8.203E-13 6.331E-12 9.844E-12 7 42
13 int:USP14 USP14 interactions 8.481E-15 8.233E-13 6.354E-12 1.070E-11 8 85
14 int:ADRM1 ADRM1 interactions 9.346E-15 8.424E-13 6.502E-12 1.179E-11 8 86
15 int:PSMC4 PSMC4 interactions 1.455E-14 1.224E-12 9.445E-12 1.836E-11 9 160
16 int:PSMB7 PSMB7 interactions 2.131E-14 1.681E-12 1.297E-11 2.690E-11 8 95
17 int:PSMD8 PSMD8 interactions 3.255E-14 2.416E-12 1.865E-11 4.107E-11 8 100
18 int:FKBP8 FKBP8 interactions 3.533E-14 2.477E-12 1.912E-11 4.458E-11 8 101
19 int:PSMB3 PSMB3 interactions 4.864E-14 3.231E-12 2.494E-11 6.138E-11 8 105
20 int:PSMB4 PSMB4 interactions 5.681E-14 3.584E-12 2.766E-11 7.169E-11 8 107
21 int:PSMB2 PSMB2 interactions 8.266E-14 4.742E-12 3.660E-11 1.043E-10 8 112
22 int:PSMB6 PSMB6 interactions 8.266E-14 4.742E-12 3.660E-11 1.043E-10 8 112
23 int:PSMD13 PSMD13 interactions 9.557E-14 5.244E-12 4.047E-11 1.206E-10 8 114
24 int:PSMD1 PSMD1 interactions 1.166E-13 6.132E-12 4.733E-11 1.472E-10 9 201
25 int:PSMB5 PSMB5 interactions 1.359E-13 6.858E-12 5.293E-11 1.714E-10 8 119
26 int:PSMA4 PSMA4 interactions 1.902E-13 9.233E-12 7.126E-11 2.401E-10 8 124
27 int:PSMD14 PSMD14 interactions 2.627E-13 1.228E-11 9.477E-11 3.315E-10 8 129
28 int:PSMA7 PSMA7 interactions 2.798E-13 1.261E-11 9.733E-11 3.531E-10 8 130
29 int:PSMD7 PSMD7 interactions 3.169E-13 1.379E-11 1.064E-10 3.999E-10 8 132
30 int:PSMD6 PSMD6 interactions 3.370E-13 1.418E-11 1.094E-10 4.253E-10 8 133
31 int:PSMB9 PSMB9 interactions 4.190E-13 1.641E-11 1.266E-10 5.288E-10 7 72
32 int:PSMB1 PSMB1 interactions 4.290E-13 1.641E-11 1.266E-10 5.414E-10 8 137
33 int:SEM1 SEM1 interactions 4.290E-13 1.641E-11 1.266E-10 5.414E-10 8 137
34 int:PSMA2 PSMA2 interactions 5.117E-13 1.899E-11 1.466E-10 6.458E-10 8 140
35 int:PSMA5 PSMA5 interactions 1.053E-12 3.796E-11 2.930E-10 1.329E-9 8 153
36 int:RAD23A RAD23A interactions 1.110E-12 3.891E-11 3.003E-10 1.401E-9 8 154
37 int:NOS2 NOS2 interactions 1.170E-12 3.912E-11 3.019E-10 1.476E-9 8 155
38 int:ATG4C ATG4C interactions 1.178E-12 3.912E-11 3.019E-10 1.487E-9 5 14
39 int:PSMA6 PSMA6 interactions 1.232E-12 3.988E-11 3.078E-10 1.555E-9 8 156
40 int:PSMD3 PSMD3 interactions 1.591E-12 5.020E-11 3.875E-10 2.008E-9 8 161
41 int:PSMA8 PSMA8 interactions 1.635E-12 5.034E-11 3.885E-10 2.064E-9 6 40
42 int:PSMD11 PSMD11 interactions 2.140E-12 6.429E-11 4.962E-10 2.700E-9 8 167
43 int:PSMC1 PSMC1 interactions 2.356E-12 6.757E-11 5.215E-10 2.973E-9 8 169
44 int:CAD CAD interactions 2.356E-12 6.757E-11 5.215E-10 2.973E-9 8 169
45 int:PSMA3 PSMA3 interactions 3.308E-12 9.278E-11 7.161E-10 4.175E-9 9 291
46 int:FBXO25 FBXO25 interactions 7.170E-12 1.967E-10 1.518E-9 9.049E-9 8 194
47 int:PSMC2 PSMC2 interactions 8.113E-12 2.178E-10 1.681E-9 1.024E-8 8 197
48 int:PMS2 PMS2 interactions 9.708E-12 2.552E-10 1.970E-9 1.225E-8 6 53
49 int:DNM1L DNM1L interactions 1.074E-11 2.767E-10 2.135E-9 1.356E-8 8 204
50 int:PSMD2 PSMD2 interactions 1.638E-11 4.134E-10 3.191E-9 2.067E-8 8 215
Show 45 more annotations

10: Cytoband [Display Chart] 18 input genes in category / 18 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19q13.11-q13.13 19q13.11-q13.13 5.193E-4 4.674E-3 1.634E-2 9.348E-3 1 1
2 7q22.1-q22.3 7q22.1-q22.3 5.193E-4 4.674E-3 1.634E-2 9.348E-3 1 1
3 18p11 18p11 3.112E-3 1.867E-2
6.526E-2
5.602E-2
 1 6
4 14q32.11 14q32.11 9.824E-3 2.784E-2
9.732E-2
1.768E-1
 1 19
5 12q24.23 12q24.23 1.034E-2 2.784E-2
9.732E-2
1.861E-1
 1 20
6 6p25.2 6p25.2 1.188E-2 2.784E-2
9.732E-2
2.138E-1
 1 23
7 3q21 3q21 1.239E-2 2.784E-2
9.732E-2
2.231E-1
 1 24
8 3q27 3q27 1.291E-2 2.784E-2
9.732E-2
2.323E-1
 1 25
9 3q27.1 3q27.1 1.393E-2 2.784E-2
9.732E-2
2.508E-1
 1 27
10 17q23.3 17q23.3 1.547E-2 2.784E-2
9.732E-2
2.784E-1
 1 30
11 5p15.33 5p15.33 1.803E-2 2.950E-2
1.031E-1
3.245E-1
 1 35
Show 6 more annotations

11: Transcription Factor Binding Site [Display Chart] 17 input genes in category / 55 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 17 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 413 AAA ATPases genenames.org 1.405E-37 8.433E-37 2.066E-36 8.433E-37 15 53
2 690 Proteasome genenames.org 4.709E-15 1.413E-14 3.461E-14 2.826E-14 7 43
3 1329 YEATS domain containing|SRCAP complex genenames.org 2.947E-5 5.894E-5 1.444E-4 1.768E-4 2 9
4 595 INO80 complex genenames.org 8.567E-5 1.285E-4 3.148E-4 5.140E-4 2 15
5 1167 INO80 complex |DNA helicases genenames.org 1.108E-4 1.330E-4 3.259E-4 6.650E-4 2 17
6 1120 AAA ATPases|ESCRT-IV genenames.org 2.801E-3 2.801E-3 6.862E-3 1.680E-2 1 3
Show 1 more annotation

13: Coexpression [Display Chart] 18 input genes in category / 1510 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20460173-ImmPortAntigenProcessingandPresentation Human Immune Kong10 148genes ImmPort AntigenProcessingandPresentation GeneSigDB 5.428E-14 8.196E-11 6.473E-10 8.196E-11 8 138
2 M4533 Genes down-regulated in comparison of unstimulated NK cells versus those stimulated with IL2 [GeneID=3600] at 16 h. MSigDB C7: Immunologic Signatures (v6.0) 6.589E-9 3.317E-6 2.619E-5 9.950E-6 6 200
3 M4601 Genes up-regulated in comparison of CD25+ T cells treated with IL4 [GeneID=3565] versus CD25- T cells treated with IL4 [GeneID=3565] at day 5. MSigDB C7: Immunologic Signatures (v6.0) 6.589E-9 3.317E-6 2.619E-5 9.950E-6 6 200
4 M8341 Antigen processing and presentation genes down-regulated in JY cells (B lymphocytes) treated with trichostatin A (TSA) [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.314E-8 1.605E-5 1.267E-4 8.024E-5 4 49
5 16188652-table1a Human StemCell Shaughnessy05 51genes GeneSigDB 5.314E-8 1.605E-5 1.267E-4 8.024E-5 4 49
6 M10633 Genes which comprise the top 1% of highly interconnected genes (major hubs) that account for most of gene interactions in the reconstructed regulatory networks from expression profiles in B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.751E-8 1.616E-5 1.276E-4 1.019E-4 5 143
7 M9372 Genes involved in DNA replication, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.490E-8 1.616E-5 1.276E-4 1.131E-4 5 146
8 M8365 Genes commonly up-regulated in undifferentiated cancer relative to well-differentiated cancer, based on the meta-analysis of the OncoMine gene expression database. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.147E-7 3.990E-5 3.151E-4 3.243E-4 4 69
9 15260889-TableS2a Human Breast Dairkee04 479genes GeneSigDB 2.378E-7 3.990E-5 3.151E-4 3.591E-4 6 366
10 M2188 Genes encoding mRNA transcripts specifically bound by DCP2 [GeneID=167227]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.006E-7 9.070E-5 7.163E-4 9.070E-4 4 89
11 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.166E-7 9.837E-5 7.769E-4 1.082E-3 5 230
12 19074878-SuppTable1 Human Leukemia Hillion08 1176genes GeneSigDB 1.018E-6 1.282E-4 1.012E-3 1.538E-3 5 247
13 17145885-Table2 Human Lung Kobayashi06 42genes GeneSigDB 1.584E-6 1.840E-4 1.453E-3 2.392E-3 3 30
14 M16975 Up-regulated genes in peripheral zone of human pancreatic cancer growing in the pancreas of nude mice compared to that of the tumor from the central zone. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.022E-6 2.181E-4 1.722E-3 3.053E-3 5 284
15 M123 Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells, embryonical carcinomas and induced pluripotent cells). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.602E-6 2.578E-4 2.036E-3 3.929E-3 5 299
16 20103679-ST3-B Human Breast Wood10 416genes GeneSigDB 2.732E-6 2.578E-4 2.036E-3 4.125E-3 5 302
17 M2156 Genes up-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChem=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.852E-6 3.421E-4 2.702E-3 5.816E-3 5 324
18 M5898 Genes involved in DNA repair. MSigDB H: Hallmark Gene Sets (v6.0) 4.839E-6 4.059E-4 3.206E-3 7.306E-3 4 150
19 17210693-Table1 Human pancreas Fidler07 50genes InVitro GeneSigDB 5.496E-6 4.368E-4 3.450E-3 8.300E-3 3 45
20 M2427 Genes down-regulated in pancreatic cancer cells grown in orthotopic xenograft tumors compared to those grown in vitro. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.877E-6 4.437E-4 3.504E-3 8.874E-3 3 46
21 M2431 DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.383E-5 7.101E-4 5.608E-3 2.089E-2 3 61
22 M5102 Genes up-regulated in comparison of untreated CD8+ dendritic cells (DC) at 4 h versus those treated with IFNG [GeneID=3458] at 16 h. MSigDB C7: Immunologic Signatures (v6.0) 1.478E-5 7.101E-4 5.608E-3 2.232E-2 4 199
23 M7308 Genes up-regulated in lymphocytes treated with TNF [GeneID=7124] for 24h: T conv versus T reg cells. MSigDB C7: Immunologic Signatures (v6.0) 1.508E-5 7.101E-4 5.608E-3 2.277E-2 4 200
24 M3594 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 24 h after stimulation with antigen-B7-1. MSigDB C7: Immunologic Signatures (v6.0) 1.508E-5 7.101E-4 5.608E-3 2.277E-2 4 200
25 M7609 Genes down-regulated in CD11b BoneMarrow from BALBc mouse incubated with GMCSF and IL-6 versus CD11b BoneMarrow from BALBc mouse incubated with GMCSF and GCSF. MSigDB C7: Immunologic Signatures (v6.0) 1.508E-5 7.101E-4 5.608E-3 2.277E-2 4 200
26 M6555 Genes up-regulated in monocyte-derived dendritic cells: untreated versus AM580 [PubChem=2126]. MSigDB C7: Immunologic Signatures (v6.0) 1.508E-5 7.101E-4 5.608E-3 2.277E-2 4 200
27 M6553 Genes up-regulated in monocyte-derived dendritic cells: untreated versus rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v6.0) 1.508E-5 7.101E-4 5.608E-3 2.277E-2 4 200
28 M3591 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 24 h after stimulation with IL12 . MSigDB C7: Immunologic Signatures (v6.0) 1.508E-5 7.101E-4 5.608E-3 2.277E-2 4 200
29 M3588 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 1.508E-5 7.101E-4 5.608E-3 2.277E-2 4 200
30 M9437 Genes up-regulated in comparison between in vitro derived induced T reg (iTreg) and converted ex iTreg. MSigDB C7: Immunologic Signatures (v6.0) 1.508E-5 7.101E-4 5.608E-3 2.277E-2 4 200
31 M5300 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from old donors versus those treated with TSST at 40 h. MSigDB C7: Immunologic Signatures (v6.0) 1.508E-5 7.101E-4 5.608E-3 2.277E-2 4 200
32 M3439 Genes up-regulated in comparison of intrathymic T progenitor cells (ITTP) versus CD4 [GeneID=920] thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.508E-5 7.101E-4 5.608E-3 2.277E-2 4 200
33 M19511 Genes up-regulated in fibroblasts with defective XPC [GeneID=7508] in response to cisplatin [PubChem=2767]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.568E-5 7.101E-4 5.608E-3 2.368E-2 4 202
34 M7488 Antigen processing and presentation genes up-regulated in JY cells (B lymphocytes) treated with TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.599E-5 7.101E-4 5.608E-3 2.415E-2 3 64
35 M1319 Genes up-regulated in hematopoietic precursor cells conditionally expressing HOXA9 and MEIS1 [GeneID=3205;4211]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.676E-5 7.229E-4 5.709E-3 2.530E-2 3 65
36 15284076-TableE2 Human Lung not cancer Golpon04 242genes GeneSigDB 1.826E-5 7.661E-4 6.050E-3 2.758E-2 4 210
37 M8520 Cluster 6 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts poor survival outcome. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.016E-5 8.229E-4 6.499E-3 3.045E-2 5 456
38 20156340-GENIUS-ERposHER2neg signature Human Breast HaibeKains10 229genes GENIUS ERposHER2neg GeneSigDB 2.192E-5 8.488E-4 6.703E-3 3.310E-2 4 220
39 18698033-tableS1-AURKA Human Breast Desmedt08 229genes AURKA Module GeneSigDB 2.192E-5 8.488E-4 6.703E-3 3.310E-2 4 220
40 15374877-Table2 Human StemCell Manalo05 108genes GeneSigDB 3.247E-5 1.226E-3 9.682E-3 4.904E-2 3 81
41 17145885-SuppTable2 Human Lung Kobayashi06 320genes GeneSigDB 3.448E-5 1.270E-3 1.003E-2
5.207E-2
 4 247
42 M16010 Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.671E-5 1.318E-3 1.041E-2
5.544E-2
 4 251
43 M2606 Cell cycle genes significantly (p =< 0.05) changed in fibroblast cells at 6 h after exposure to ionizing radiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.752E-5 1.318E-3 1.041E-2
5.666E-2
 3 85
44 12086872-Table12c Human Leukemia Yeoh02 96genes GeneSigDB 4.452E-5 1.528E-3 1.207E-2
6.723E-2
 3 90
45 19965622-TableS1a Human LymphaticEndothelialCells Norrmen09 107genes GeneSigDB 4.754E-5 1.595E-3 1.260E-2
7.179E-2
 3 92
46 15896717-Table6 Human Leukemia Bal05 15genes GeneSigDB 5.966E-5 1.959E-3 1.547E-2
9.009E-2
 2 15
47 M18562 Genes down-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.354E-5 2.026E-3 1.600E-2
9.595E-2
 4 289
48 M14985 Genes up-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.440E-5 2.026E-3 1.600E-2
9.725E-2
 4 290
49 M19745 Genes down-regulated in mature plasma cells compared with plasmablastic B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.133E-5 2.506E-3 1.979E-2
1.228E-1
 4 308
50 M10973 Genes changed in MGUS (monoclonal gammopathy of undetermined significance) compared to PCL (plasma cell leukemia) samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.244E-5 2.792E-3 2.205E-2
1.396E-1
 3 115
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 18 input genes in category / 489 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eProg Subtype eProg2b Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eProg Subtype eProg2b Top 200 Genes GSE76381_ESMoleculeCountsPMLog2 6.095E-6 1.368E-3 9.263E-3 2.980E-3 5 336
2 10X Human 8K PBMC unknown Subtype unknown-T cell CD4 - B Top 200 Genes 10X Human 8K PBMC unknown Subtype unknown-T cell CD4 - B Top 200 Genes 1.286E-5 1.368E-3 9.263E-3 6.290E-3 5 392
3 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin/stem cell of epidermis Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin/stem cell of epidermis Tabula Muris Consortium 1.579E-5 1.368E-3 9.263E-3 7.721E-3 4 191
4 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/Slamf1-positive multipotent progenitor cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/Slamf1-positive multipotent progenitor cell Tabula Muris Consortium 1.579E-5 1.368E-3 9.263E-3 7.721E-3 4 191
5 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/megakaryocyte-erythroid progenitor cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/megakaryocyte-erythroid progenitor cell Tabula Muris Consortium 1.612E-5 1.368E-3 9.263E-3 7.881E-3 4 192
6 Cap mesenchyme (CM) Cap mesenchyme (CM) 1.679E-5 1.368E-3 9.263E-3 8.209E-3 4 194
7 Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte progenitor Enterocyte progenitor Subtype progenitor Ileum Top 200 Genes Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte progenitor Enterocyte progenitor Subtype progenitor Ileum Top 200 Genes Mouse Cell Atlas 9.673E-5 5.765E-3 3.903E-2 4.730E-2 4 304
8 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes BrainMap 1.179E-4 5.765E-3 3.903E-2
5.765E-2
 4 320
9 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200 1.179E-4 5.765E-3 3.903E-2
5.765E-2
 4 320
10 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes 1.179E-4 5.765E-3 3.903E-2
5.765E-2
 4 320
11 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eProg Subtype eProg2a Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eProg Subtype eProg2a Top 200 Genes GSE76381_ESMoleculeCountsPMLog2 1.359E-4 6.039E-3 4.089E-2
6.643E-2
 4 332
12 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Poorly Differentiated or Epithelioid Leiomyosarcoma/1/2 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Poorly Differentiated or Epithelioid Leiomyosarcoma/1/2 TCGA-Bone and Soft Tissue 2.962E-4 1.178E-2
7.974E-2
1.448E-1
 3 161
13 GSM791149 500 alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 3.131E-4 1.178E-2
7.974E-2
1.531E-1
 4 413
14 GSM791131 500 B cells, MLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-3 Immgen.org, GSE15907 3.491E-4 1.219E-2
8.256E-2
1.707E-1
 4 425
15 Lungmap Mouse Lung E16.5 Endothelial Subtype Proliferative Endothelial Lungmap Mouse Lung E16.5 Endothelial Subtype Proliferative Endothelial Lungmap CCHMC 4.262E-4 1.390E-2
9.408E-2
2.084E-1
 4 448
16 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/Slamf1-negative multipotent progenitor cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/Slamf1-negative multipotent progenitor cell Tabula Muris Consortium 4.736E-4 1.431E-2
9.687E-2
2.316E-1
 3 189
17 10X Human 8K PBMC unknown Overall Top 200 Genes 10X Human 8K PBMC unknown Overall Top 200 Genes 5.266E-4 1.431E-2
9.687E-2
2.575E-1
 3 196
18 Extraglomerular mesangium (EM)/Extraglomerular mesangium (EM) b Extraglomerular mesangium (EM)/Extraglomerular mesangium (EM) b 5.266E-4 1.431E-2
9.687E-2
2.575E-1
 3 196
19 GSM605775 500 gamma delta T cells, Tgd.vg1+vd6+.Th, TCRd+ Vd6.3+ Vg1.1+, Thymus, avg-1 Immgen.org, GSE15907 1.940E-3 4.537E-2
3.072E-1
9.485E-1
 3 308
20 Kidney10XCellRanger Six2KI E14 NPC NPC Subtype E14-Six2KI-NPCU-C1-KC3 Top 200 Genes Kidney10XCellRanger Six2KI E14 NPC NPC Subtype E14-Six2KI-NPCU-C1-KC3 Top 200 Genes 2.049E-3 4.537E-2
3.072E-1
1.000E0
 3 314
21 GSM791131 100 B cells, MLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-3 Immgen.org, GSE15907 2.101E-3 4.537E-2
3.072E-1
1.000E0
 2 83
22 GSM791143 100 alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 2.202E-3 4.537E-2
3.072E-1
1.000E0
 2 85
23 GSM791154 100 alpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 2.202E-3 4.537E-2
3.072E-1
1.000E0
 2 85
24 GSM791149 100 alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 2.305E-3 4.537E-2
3.072E-1
1.000E0
 2 87
25 10X Human 8K PBMC unknown Subtype unknown-T cells CD8 - D CCL5 positive Top 200 Genes 10X Human 8K PBMC unknown Subtype unknown-T cells CD8 - D CCL5 positive Top 200 Genes 2.320E-3 4.537E-2
3.072E-1
1.000E0
 3 328
26 Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte progenitor Enterocyte progenitor Subtype progenitor Duodenum Top 200 Genes Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte progenitor Enterocyte progenitor Subtype progenitor Duodenum Top 200 Genes Mouse Cell Atlas 2.443E-3 4.537E-2
3.072E-1
1.000E0
 3 334
27 Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype Uncommitted AE Progenitor E16.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype Uncommitted AE Progenitor E16.5 Top 200 Genes 2.505E-3 4.537E-2
3.072E-1
1.000E0
 3 337
28 Kidney10XCellRanger Six2KI E14 NPC NPC Subtype E14-Six2KI-NPCU-C5-KC5 Top 200 Genes Kidney10XCellRanger Six2KI E14 NPC NPC Subtype E14-Six2KI-NPCU-C5-KC5 Top 200 Genes 2.612E-3 4.559E-2
3.087E-1
1.000E0
 3 342
29 BrainMap BrainAtlas - Human / Mouse Linnarsson Neuron Neuron Subtype Peptidergic Top 200 Genes BrainMap BrainAtlas - Human / Mouse Linnarsson Neuron Neuron Subtype Peptidergic Top 200 Genes BrainMap 2.722E-3 4.559E-2
3.087E-1
1.000E0
 3 347
30 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex Wilms R U/Kidney Normal-Cortex Wilms R13 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex Wilms R U/Kidney Normal-Cortex Wilms R13 Adult, Development, and Cancer types 2.797E-3 4.559E-2
3.087E-1
1.000E0
 2 96
31 Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC7 Top 200 Genes Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC7 Top 200 Genes 3.091E-3 4.876E-2
3.302E-1
1.000E0
 3 363
Show 26 more annotations

15: Computational [Display Chart] 16 input genes in category / 153 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M16869 MODULE 28 Genes in the cancer module 28. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.005E-12 7.658E-10 4.297E-9 7.658E-10 6 32
2 M4414 MODULE 91 Proteasome. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.279E-11 9.781E-10 5.488E-9 1.956E-9 6 37
3 M19325 MORF PSMC1 Neighborhood of PSMC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.909E-7 1.113E-5 6.243E-5 4.450E-5 6 190
4 M13609 MORF PRKDC Neighborhood of PRKDC MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.909E-7 1.113E-5 6.243E-5 4.450E-5 6 190
5 M17658 MODULE 198 Genes in the cancer module 198. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.469E-6 1.367E-4 7.672E-4 6.837E-4 6 303
6 M949 MODULE 244 Response to DNA damage. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.868E-6 2.006E-4 1.126E-3 1.204E-3 5 187
7 M7887 MORF RAD54L Neighborhood of RAD54L MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.869E-5 3.804E-4 2.134E-3 2.859E-3 4 105
8 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.989E-5 3.804E-4 2.134E-3 3.043E-3 6 393
9 M4550 MODULE 252 TFs and nuclear. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.485E-5 4.224E-4 2.370E-3 3.801E-3 5 237
10 M6330 MODULE 158 DNA replication. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.946E-5 5.884E-4 3.301E-3 6.037E-3 3 43
11 M15402 MODULE 125 Genes in the cancer module 125. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.230E-5 5.884E-4 3.301E-3 6.472E-3 3 44
12 M382 MORF EI24 Neighborhood of EI24 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.124E-5 7.325E-4 4.110E-3 9.369E-3 4 142
13 M13790 MORF PPP2R4 Neighborhood of PPP2R4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.224E-5 7.325E-4 4.110E-3 9.523E-3 3 50
14 M13545 MORF RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.584E-5 8.288E-4 4.650E-3 1.160E-2 4 150
15 M18803 MORF RAD23B Neighborhood of RAD23B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.505E-4 1.535E-3 8.616E-3 2.303E-2 4 179
16 M11176 MORF CDK2 Neighborhood of CDK2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.778E-4 1.700E-3 9.541E-3 2.721E-2 3 71
17 M4409 MODULE 17 Genes in the cancer module 17. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.990E-4 1.791E-3 1.005E-2 3.045E-2 5 367
18 M15222 MORF AATF Neighborhood of AATF MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.536E-4 2.156E-3 1.210E-2 3.881E-2 4 205
19 M956 MODULE 8 Genes in the cancer module 8. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.772E-4 3.037E-3 1.704E-2
5.771E-2
 5 421
20 M5047 MORF DDB1 Neighborhood of DDB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.700E-4 3.400E-3 1.908E-2
7.191E-2
 4 241
21 M18698 MORF EIF3S2 Neighborhood of EIF3S2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.926E-4 3.400E-3 1.908E-2
7.536E-2
 4 244
22 M15619 MODULE 18 Genes in the cancer module 18. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.182E-4 3.400E-3 1.908E-2
7.929E-2
 5 451
23 M1104 MORF RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.183E-4 3.400E-3 1.908E-2
7.930E-2
 3 102
24 M13621 MORF PPP6C Neighborhood of PPP6C MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.334E-4 3.400E-3 1.908E-2
8.160E-2
 3 103
25 M10146 MORF DNMT1 Neighborhood of DNMT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.739E-4 4.736E-3 2.657E-2
1.184E-1
 3 117
26 M10065 GNF2 CKS1B Neighborhood of CKS1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.536E-3 9.039E-3
5.072E-2
2.350E-1
 2 37
27 M18610 MORF PPP1CC Neighborhood of PPP1CC MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.051E-3 1.162E-2
6.522E-2
3.138E-1
 3 164
28 M9199 MODULE 3 Genes in the cancer module 3. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.687E-3 1.468E-2
8.239E-2
4.112E-1
 4 385
29 M19913 MORF USP5 Neighborhood of USP5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.791E-3 1.473E-2
8.263E-2
4.271E-1
 2 50
30 M6058 MORF DAP3 Neighborhood of DAP3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.259E-3 1.662E-2
9.326E-2
4.986E-1
 3 193
31 M14325 GNF2 FEN1 Neighborhood of FEN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.490E-3 1.722E-2
9.663E-2
5.339E-1
 2 56
32 M5380 MORF BAG5 Neighborhood of BAG5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.613E-3 1.728E-2
9.693E-2
5.528E-1
 2 57
33 M5444 GNF2 RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.996E-3 1.804E-2
1.012E-1
6.114E-1
 2 60
34 M10414 MORF ESPL1 Neighborhood of ESPL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.127E-3 1.804E-2
1.012E-1
6.315E-1
 2 61
35 M17234 MORF MSH2 Neighborhood of MSH2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.127E-3 1.804E-2
1.012E-1
6.315E-1
 2 61
36 M1964 MORF PRKAG1 Neighborhood of PRKAG1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.651E-3 1.977E-2
1.109E-1
7.116E-1
 3 219
37 M5625 MORF BUB1B Neighborhood of BUB1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.816E-3 1.991E-2
1.117E-1
7.368E-1
 2 66
38 M18220 MORF CCNF Neighborhood of CCNF MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.502E-3 2.618E-2
1.469E-1
9.948E-1
 2 77
39 M12803 MORF ATOX1 Neighborhood of ATOX1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.003E-3 2.747E-2
1.541E-1
1.000E0
 2 80
40 M5468 MODULE 54 Cell cycle (expression cluster). MSigDb: C4 - CM: Cancer Modules (v6.0) 7.654E-3 2.872E-2
1.612E-1
1.000E0
 3 262
41 M18743 MORF EIF4E Neighborhood of EIF4E MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.697E-3 2.872E-2
1.612E-1
1.000E0
 2 84
42 M10404 MORF MBD4 Neighborhood of MBD4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.055E-3 2.934E-2
1.646E-1
1.000E0
 2 86
43 M13419 MORF BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.832E-3 3.033E-2
1.702E-1
1.000E0
 3 276
44 M7895 MORF SOD1 Neighborhood of SOD1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.920E-3 3.033E-2
1.702E-1
1.000E0
 3 277
45 M11406 MORF HDAC2 Neighborhood of HDAC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.920E-3 3.033E-2
1.702E-1
1.000E0
 3 277
46 M18002 MORF CSNK2B Neighborhood of CSNK2B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.828E-3 3.269E-2
1.834E-1
1.000E0
 3 287
47 M10545 MORF RAB5A Neighborhood of RAB5A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.016E-2 3.306E-2
1.855E-1
1.000E0
 2 97
48 M5260 MODULE 72 Testis genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.223E-2 3.897E-2
2.187E-1
1.000E0
 3 311
49 M11641 MORF PSMC2 Neighborhood of PSMC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.453E-2 4.537E-2
2.546E-1
1.000E0
 2 117
50 M7493 MORF PHB Neighborhood of PHB MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.598E-2 4.849E-2
2.721E-1
1.000E0
 2 123
Show 45 more annotations

16: MicroRNA [Display Chart] 18 input genes in category / 310 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1180:mirSVR highEffct hsa-miR-1180:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.138E-6 2.213E-3 1.398E-2 2.213E-3 3 151
2 hsa-miR-1273c:mirSVR lowEffct hsa-miR-1273c:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.866E-5 5.541E-3 3.499E-2 1.199E-2 3 266
3 hsa-miR-324-5p:Functional MTI Functional MTI miRTarbase 5.362E-5 5.541E-3 3.499E-2 1.662E-2 3 297
4 hsa-miR-324-3p:Functional MTI Functional MTI miRTarbase 7.863E-5 6.094E-3 3.848E-2 2.437E-2 3 338
5 hsa-miR-1273:mirSVR lowEffct hsa-miR-1273:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.249E-4 1.394E-2
8.807E-2
6.972E-2
 3 483
6 hsa-miR-194-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.973E-4 2.570E-2
1.623E-1
1.542E-1
 2 132
7 hsa-miR-1200:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.377E-4 3.267E-2
2.063E-1
2.287E-1
 2 161
8 hsa-miR-658:mirSVR highEffct hsa-miR-658:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.167E-3 4.178E-2
2.638E-1
3.618E-1
 2 203
9 hsa-miR-1229-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.213E-3 4.178E-2
2.638E-1
3.760E-1
 2 207
10 hsa-miR-532-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.368E-3 4.240E-2
2.678E-1
4.240E-1
 2 220
11 hsa-miR-766-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.506E-3 4.244E-2
2.680E-1
4.668E-1
 2 231
Show 6 more annotations

17: Drug [Display Chart] 18 input genes in category / 855 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:D010882 Piperonyl Butoxide CTD 5.588E-10 2.433E-7 1.783E-6 4.778E-7 8 431
2 CID000105082 AC1L2Y08 Stitch 5.691E-10 2.433E-7 1.783E-6 4.866E-7 8 432
3 CID000061668 boronic acid Stitch 4.352E-9 1.052E-6 7.707E-6 3.721E-6 5 82
4 CID006476006 beta-lactone Stitch 4.920E-9 1.052E-6 7.707E-6 4.206E-6 5 84
5 CID000001051 pyridoxal 5'-phosphate Stitch 8.097E-8 1.385E-5 1.015E-4 6.923E-5 6 301
6 CID000093860 Velcade (bortezomib Stitch 2.911E-7 4.148E-5 3.040E-4 2.489E-4 6 374
7 CID005288710 DB08124 Stitch 5.417E-7 6.281E-5 4.603E-4 4.631E-4 3 21
8 ctd:C031280 pyrazole CTD 6.552E-7 6.281E-5 4.603E-4 5.602E-4 5 223
9 CID005458193 CID5458193 Stitch 6.611E-7 6.281E-5 4.603E-4 5.653E-4 4 90
10 CID000000738 glutamin Stitch 9.887E-7 8.454E-5 6.195E-4 8.454E-4 6 461
11 CID000522072 S-OH Stitch 1.822E-6 1.303E-4 9.551E-4 1.558E-3 3 31
12 CID000000152 NSC333308 Stitch 1.829E-6 1.303E-4 9.551E-4 1.564E-3 4 116
13 CID000004332 Calpain inhibitor I Stitch 2.008E-6 1.321E-4 9.680E-4 1.717E-3 5 280
14 CID000002969 decanoate Stitch 2.971E-6 1.712E-4 1.255E-3 2.540E-3 4 131
15 CID000004795 AC1L1IZ2 Stitch 3.004E-6 1.712E-4 1.255E-3 2.568E-3 5 304
16 CID000098928 N-acetyl-4-thiazolidinecarboxylic acid Stitch 3.407E-6 1.821E-4 1.334E-3 2.913E-3 3 38
17 ctd:C063002 2,3-dimethoxy-1,4-naphthoquinone CTD 5.506E-6 2.769E-4 2.029E-3 4.707E-3 4 153
18 CID000002538 NSC302991 Stitch 6.223E-6 2.956E-4 2.166E-3 5.321E-3 5 353
19 CID005311341 ATP betaS Stitch 6.904E-6 3.107E-4 2.277E-3 5.903E-3 4 162
20 ctd:C512195 elesclomol CTD 7.401E-6 3.164E-4 2.319E-3 6.328E-3 3 49
21 ctd:C019499 2-nitrofluorene CTD 8.952E-6 3.547E-4 2.600E-3 7.654E-3 4 173
22 ctd:D015741 Metribolone CTD 9.128E-6 3.547E-4 2.600E-3 7.804E-3 5 382
23 CID000002532 AC1L1DW2 Stitch 1.192E-5 4.429E-4 3.246E-3 1.019E-2 4 186
24 CID000002028 ATP,Gamma S Stitch 1.269E-5 4.521E-4 3.313E-3 1.085E-2 4 189
25 CID006438325 AC1O5PH2 Stitch 1.367E-5 4.676E-4 3.427E-3 1.169E-2 3 60
26 ctd:C037219 quinoline CTD 1.994E-5 6.559E-4 4.807E-3 1.705E-2 3 68
27 ctd:C016340 o,p'-DDT CTD 2.122E-5 6.720E-4 4.925E-3 1.814E-2 5 455
28 ctd:D014800 Vitallium CTD 3.456E-5 1.055E-3 7.734E-3 2.955E-2 4 244
29 CID004369285 BIA 3-335 Stitch 4.179E-5 1.232E-3 9.030E-3 3.573E-2 3 87
30 ctd:C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD 6.768E-5 1.929E-3 1.414E-2
5.787E-2
 4 290
31 ctd:D005001 Ethionine CTD 7.920E-5 2.184E-3 1.601E-2
6.771E-2
 4 302
32 CID000005561 trimitan Stitch 8.908E-5 2.380E-3 1.744E-2
7.616E-2
 2 18
33 ctd:D001553 Benzbromarone CTD 1.129E-4 2.924E-3 2.143E-2
9.650E-2
 4 331
34 ctd:D011084 Polycyclic Aromatic Hydrocarbons CTD 1.350E-4 3.307E-3 2.423E-2
1.154E-1
 3 129
35 ctd:D008701 Methapyrilene CTD 1.354E-4 3.307E-3 2.423E-2
1.157E-1
 4 347
36 CID000004592 olomoucine Stitch 1.445E-4 3.431E-3 2.515E-2
1.235E-1
 3 132
37 CID000000621 NSC82625 Stitch 1.648E-4 3.807E-3 2.790E-2
1.409E-1
 3 138
38 ctd:D002713 Chlorine CTD 1.696E-4 3.817E-3 2.797E-2
1.450E-1
 4 368
39 ctd:D009853 Omeprazole CTD 2.037E-4 4.397E-3 3.222E-2
1.741E-1
 4 386
40 ctd:D006997 Hypochlorous Acid CTD 2.057E-4 4.397E-3 3.222E-2
1.759E-1
 4 387
41 CID000024561 silver chloride Stitch 2.190E-4 4.568E-3 3.348E-2
1.873E-1
 2 28
42 CID000024437 sodium bisulfite Stitch 2.277E-4 4.635E-3 3.397E-2
1.947E-1
 3 154
43 CID000003657 hydroxyurea Stitch 3.297E-4 6.556E-3 4.805E-2
2.819E-1
 4 438
44 ctd:C032036 bromobenzene CTD 3.600E-4 6.995E-3
5.126E-2
3.078E-1
 3 180
45 CID006420160 2f34 Stitch 4.088E-4 7.673E-3
5.623E-2
3.495E-1
 3 188
46 CID000001693 4-hydroxynonenal Stitch 4.342E-4 7.673E-3
5.623E-2
3.712E-1
 4 471
47 1748 DN Ajmalicine hydrochloride [4373-34-6]; Down 200; 10.2uM; HL60; HG-U133A Broad Institute CMAP Down 4.481E-4 7.673E-3
5.623E-2
3.831E-1
 3 194
48 ctd:D006820 Hyaluronic Acid CTD 4.481E-4 7.673E-3
5.623E-2
3.831E-1
 3 194
49 1985 DN Isoxsuprine hydrochloride [579-56-6]; Down 200; 11.8uM; HL60; HG-U133A Broad Institute CMAP Down 4.549E-4 7.673E-3
5.623E-2
3.889E-1
 3 195
50 ctd:D000069439 Dasatinib CTD 4.591E-4 7.673E-3
5.623E-2
3.925E-1
 4 478
Show 45 more annotations

18: Disease [Display Chart] 17 input genes in category / 236 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 cv:C3280977 Spastic ataxia 5, autosomal recessive Clinical Variations 1.049E-3 4.952E-2
2.992E-1
2.476E-1
 1 1
2 C3280977 SPASTIC ATAXIA 5, AUTOSOMAL RECESSIVE DisGeNET Curated 1.049E-3 4.952E-2
2.992E-1
2.476E-1
 1 1
3 C1853249 SPINOCEREBELLAR ATAXIA 28 DisGeNET Curated 1.049E-3 4.952E-2
2.992E-1
2.476E-1
 1 1
4 cv:C1853249 Spinocerebellar ataxia 28 Clinical Variations 1.049E-3 4.952E-2
2.992E-1
2.476E-1
 1 1
5 OMIN:610246 SPINOCEREBELLAR ATAXIA 28; SCA28 OMIM 1.049E-3 4.952E-2
2.992E-1
2.476E-1
 1 1