|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
23287549
|
CK2 phosphorylation of human Sec63 regulates its interaction with Sec62.
|
Pubmed
|
6.170E-8
|
3.563E-5
|
2.718E-4
|
7.126E-5
|
2
|
3
|
2
|
10799540
|
Mammalian Sec61 is associated with Sec62 and Sec63.
|
Pubmed
|
6.170E-8
|
3.563E-5
|
2.718E-4
|
7.126E-5
|
2
|
3
|
3
|
22375059
|
Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.
|
Pubmed
|
1.603E-6
|
3.902E-4
|
2.977E-3
|
1.851E-3
|
2
|
13
|
4
|
22028146
|
Restriction of trophic factors and nutrients induces PARKIN expression.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
5
|
11179010
|
Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from Founder effects.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
6
|
19464273
|
Effects of partial suppression of parkin on huntingtin mutant R6/1 mice.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
7
|
26800306
|
Post-GWAS methodologies for localisation of functional non-coding variants: ANGPTL3.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
8
|
20301651
|
Parkin Type of Early-Onset Parkinson Disease
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
9
|
20818665
|
Fibrocystic disease of liver and pancreas; under-recognized features of the X-linked ciliopathy oral-facial-digital syndrome type 1 (OFD I).
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
10
|
15300670
|
Does parkin play a role in the peripheral nervous system? A family report.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
11
|
19474742
|
Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: association with insulin resistance.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
12
|
15063093
|
Parkin expression in the developing mouse.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
13
|
15192821
|
[New polymorphism (IVS3-20 T-->C) of the parkin gene associated with the early-onset Parkinson's disease in Chinese].
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
14
|
18331811
|
Brain perfusion abnormalities in a sibship with parkin-linked parkinsonism.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
15
|
11971093
|
Evaluation of 50 probands with early-onset Parkinson's disease for Parkin mutations.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
16
|
12397156
|
Relative high frequency of the c.255delA parkin gene mutation in Spanish patients with autosomal recessive parkinsonism.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
17
|
19863651
|
Somatosensory function in asymptomatic Parkin-mutation carriers.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
18
|
12362318
|
[A new point mutation on exon 2 of parkin gene in Parkinson's disease].
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
19
|
17187375
|
Heterozygous parkin point mutations are as common in control subjects as in Parkinson's patients.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
20
|
15584030
|
Novel parkin mutations detected in patients with early-onset Parkinson's disease.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
21
|
26202572
|
Interleukin-26: An Emerging Player in Host Defense and Inflammation.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
22
|
23262240
|
Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
23
|
9731209
|
Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
24
|
27590295
|
Impulsive-compulsive behaviors in parkin-associated Parkinson disease.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
25
|
25022755
|
HSPA1A-independent suppression of PARK2 C289G protein aggregation by human small heat shock proteins.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
26
|
21915905
|
Analysis of PARK2 gene exon rearrangements in Russian patients with sporadic Parkinson's disease.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
27
|
20620130
|
Impaired in vivo dopamine release in parkin knockout mice.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
28
|
14991825
|
Pael-R is accumulated in Lewy bodies of Parkinson's disease.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
29
|
19208265
|
The uterine expression of SEC63 gene is up-regulated at implantation sites in association with the decidualization during the early pregnancy in mice.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
30
|
28631565
|
Genetic and epigenetic alterations affecting PARK-2 expression in cervical neoplasm among North Indian patients.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
31
|
25656612
|
Expression pattern of parkin isoforms in lung adenocarcinomas.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
32
|
11179005
|
Identification of the gene for oral-facial-digital type I syndrome.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
33
|
25710887
|
A novel role of angiopoietin-like-3 associated with podocyte injury.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
34
|
19339245
|
Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile Parkinson-related E3 ligase parkin.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
35
|
28505061
|
Novel OFD1 frameshift mutation in a Chinese boy with Joubert syndrome: a case report and literature review.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
36
|
10939576
|
Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
37
|
15823482
|
Early-onset Parkinson's disease in a Chinese population: 99mTc-TRODAT-1 SPECT, Parkin gene analysis and clinical study.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
38
|
15229644
|
How does parkin ligate ubiquitin to Parkinson's disease?
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
39
|
17687034
|
Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
40
|
16941649
|
Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
41
|
27297116
|
Parkin Somatic Mutations Link Melanoma and Parkinson's Disease.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
42
|
24192137
|
Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
43
|
16227559
|
Mutational screening of the parkin gene among South Indians with early onset Parkinson's disease.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
44
|
19457102
|
Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
45
|
26188007
|
Heterozygote carriers for CNVs in PARK2 are at increased risk of Parkinson's disease.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
46
|
19540497
|
Plasma angiopoietin-like protein 3 (ANGPTL3) concentration is associated with uremic dyslipidemia.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
47
|
15642853
|
Parkin mutations and early-onset parkinsonism in a Taiwanese cohort.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
48
|
27798970
|
Second mutation in PARK2 is absent in patients with sporadic Parkinson's disease and heterozygous exonic deletions/duplications in parkin gene.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
49
|
24337465
|
Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|
50
|
30296568
|
Association of PARK2 promoter polymorphisms and methylation with colorectal cancer in North Indian population.
|
Pubmed
|
1.571E-4
|
3.902E-4
|
2.977E-3
|
1.814E-1
|
1
|
1
|