Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc218_9, positive side

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1: GO: Molecular Function [Display Chart] 9 input genes in category / 40 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016303 1-phosphatidylinositol-3-kinase activity 7.403E-18 2.961E-16 1.267E-15 2.961E-16 7 43
2 GO:0052742 phosphatidylinositol kinase activity 6.898E-17 1.380E-15 5.902E-15 2.759E-15 7 58
3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1.128E-16 1.504E-15 6.434E-15 4.511E-15 7 62
4 GO:0052813 phosphatidylinositol bisphosphate kinase activity 3.375E-16 3.375E-15 1.444E-14 1.350E-14 7 72
5 GO:0035004 phosphatidylinositol 3-kinase activity 5.507E-16 4.405E-15 1.885E-14 2.203E-14 7 77
6 GO:0004713 protein tyrosine kinase activity 2.648E-13 1.765E-12 7.552E-12 1.059E-11 7 182
7 GO:0005088 Ras guanyl-nucleotide exchange factor activity 1.478E-12 8.447E-12 3.614E-11 5.913E-11 7 232
8 GO:0005085 guanyl-nucleotide exchange factor activity 1.042E-11 5.212E-11 2.230E-10 4.169E-10 7 306
9 GO:0005104 fibroblast growth factor receptor binding 5.081E-10 2.258E-9 9.662E-9 2.032E-8 4 28
10 GO:0005111 type 2 fibroblast growth factor receptor binding 7.753E-10 2.819E-9 1.206E-8 3.101E-8 3 5
11 GO:0005007 fibroblast growth factor-activated receptor activity 7.753E-10 2.819E-9 1.206E-8 3.101E-8 3 5
12 GO:0008201 heparin binding 6.617E-9 2.206E-8 9.437E-8 2.647E-7 5 167
13 GO:0005539 glycosaminoglycan binding 2.579E-8 7.936E-8 3.396E-7 1.032E-6 5 219
14 GO:1901681 sulfur compound binding 6.083E-8 1.738E-7 7.436E-7 2.433E-6 5 260
15 GO:0017134 fibroblast growth factor binding 2.256E-7 6.016E-7 2.574E-6 9.023E-6 3 27
16 GO:0070851 growth factor receptor binding 4.044E-7 1.011E-6 4.325E-6 1.617E-5 4 143
17 GO:0008083 growth factor activity 7.350E-7 1.729E-6 7.399E-6 2.940E-5 4 166
18 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3.659E-6 8.131E-6 3.479E-5 1.464E-4 3 67
19 GO:0019199 transmembrane receptor protein kinase activity 9.225E-6 1.942E-5 8.310E-5 3.690E-4 3 91
20 GO:0019838 growth factor binding 3.504E-5 7.008E-5 2.999E-4 1.402E-3 3 142
21 GO:0042056 chemoattractant activity 8.338E-5 1.588E-4 6.795E-4 3.335E-3 2 29
22 GO:0005105 type 1 fibroblast growth factor receptor binding 2.409E-3 4.381E-3 1.874E-2
9.638E-2
 1 5
23 GO:0045545 syndecan binding 2.891E-3 5.027E-3 2.151E-2
1.156E-1
 1 6
24 GO:0050839 cell adhesion molecule binding 4.228E-3 7.046E-3 3.015E-2
1.691E-1
 2 208
25 GO:0044548 S100 protein binding 6.254E-3 9.621E-3 4.116E-2
2.501E-1
 1 13
26 GO:0035497 cAMP response element binding 6.254E-3 9.621E-3 4.116E-2
2.501E-1
 1 13
27 GO:0071837 HMG box domain binding 1.104E-2 1.636E-2
6.998E-2
4.416E-1
 1 23
28 GO:0043425 bHLH transcription factor binding 1.438E-2 2.054E-2
8.789E-2
5.752E-1
 1 30
29 GO:0001968 fibronectin binding 1.581E-2 2.162E-2
9.251E-2
6.323E-1
 1 33
30 GO:0030544 Hsp70 protein binding 1.628E-2 2.162E-2
9.251E-2
6.513E-1
 1 34
31 GO:0070888 E-box binding 1.676E-2 2.162E-2
9.251E-2
6.703E-1
 1 35
32 GO:0046332 SMAD binding 3.654E-2 4.567E-2
1.954E-1
1.000E0
 1 77
Show 27 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 857 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 2.001E-17 1.714E-14 1.257E-13 1.714E-14 7 49
2 GO:0071774 response to fibroblast growth factor 8.372E-17 3.587E-14 2.630E-13 7.175E-14 8 142
3 GO:0046854 phosphatidylinositol phosphorylation 2.374E-15 5.100E-13 3.739E-12 2.034E-12 7 94
4 GO:0030324 lung development 3.087E-15 5.100E-13 3.739E-12 2.646E-12 8 221
5 GO:0046834 lipid phosphorylation 3.451E-15 5.100E-13 3.739E-12 2.957E-12 7 99
6 GO:0030323 respiratory tube development 3.571E-15 5.100E-13 3.739E-12 3.060E-12 8 225
7 GO:0008543 fibroblast growth factor receptor signaling pathway 8.940E-15 1.022E-12 7.495E-12 7.662E-12 7 113
8 GO:0060541 respiratory system development 9.543E-15 1.022E-12 7.495E-12 8.178E-12 8 254
9 GO:0006661 phosphatidylinositol biosynthetic process 2.066E-14 1.967E-12 1.442E-11 1.770E-11 7 127
10 GO:0044344 cellular response to fibroblast growth factor stimulus 3.371E-14 2.889E-12 2.118E-11 2.889E-11 7 136
11 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 6.785E-14 5.286E-12 3.875E-11 5.814E-11 7 150
12 GO:0014065 phosphatidylinositol 3-kinase signaling 1.457E-13 1.041E-11 7.630E-11 1.249E-10 7 167
13 GO:0046488 phosphatidylinositol metabolic process 5.627E-13 3.709E-11 2.719E-10 4.822E-10 7 202
14 GO:0048015 phosphatidylinositol-mediated signaling 7.163E-13 4.233E-11 3.103E-10 6.139E-10 7 209
15 GO:0046474 glycerophospholipid biosynthetic process 7.409E-13 4.233E-11 3.103E-10 6.350E-10 7 210
16 GO:0048017 inositol lipid-mediated signaling 7.924E-13 4.244E-11 3.111E-10 6.790E-10 7 212
17 GO:0045017 glycerolipid biosynthetic process 1.962E-12 9.892E-11 7.252E-10 1.682E-9 7 241
18 GO:0008654 phospholipid biosynthetic process 2.690E-12 1.281E-10 9.388E-10 2.305E-9 7 252
19 GO:0030258 lipid modification 2.924E-12 1.319E-10 9.669E-10 2.506E-9 7 255
20 GO:0060638 mesenchymal-epithelial cell signaling 3.165E-12 1.356E-10 9.944E-10 2.713E-9 4 9
21 GO:0006650 glycerophospholipid metabolic process 1.268E-11 5.174E-10 3.793E-9 1.087E-8 7 314
22 GO:0035265 organ growth 3.904E-11 1.521E-9 1.115E-8 3.346E-8 6 167
23 GO:0018108 peptidyl-tyrosine phosphorylation 5.312E-11 1.967E-9 1.442E-8 4.553E-8 7 385
24 GO:0018212 peptidyl-tyrosine modification 5.509E-11 1.967E-9 1.442E-8 4.721E-8 7 387
25 GO:0046486 glycerolipid metabolic process 7.845E-11 2.689E-9 1.972E-8 6.723E-8 7 407
26 GO:0006644 phospholipid metabolic process 1.063E-10 3.502E-9 2.568E-8 9.106E-8 7 425
27 GO:0060602 branch elongation of an epithelium 1.833E-10 5.817E-9 4.264E-8 1.571E-7 4 22
28 GO:0061138 morphogenesis of a branching epithelium 2.128E-10 6.514E-9 4.775E-8 1.824E-7 6 221
29 GO:0001763 morphogenesis of a branching structure 3.245E-10 9.589E-9 7.030E-8 2.781E-7 6 237
30 GO:0060445 branching involved in salivary gland morphogenesis 5.123E-10 1.463E-8 1.073E-7 4.390E-7 4 28
31 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling 7.801E-10 2.157E-8 1.581E-7 6.685E-7 3 5
32 GO:0010634 positive regulation of epithelial cell migration 8.112E-10 2.172E-8 1.593E-7 6.952E-7 5 110
33 GO:0003401 axis elongation 1.308E-9 3.397E-8 2.490E-7 1.121E-6 4 35
34 GO:0010092 specification of animal organ identity 1.471E-9 3.708E-8 2.719E-7 1.261E-6 4 36
35 GO:0050678 regulation of epithelial cell proliferation 2.090E-9 5.117E-8 3.751E-7 1.791E-6 6 323
36 GO:0007435 salivary gland morphogenesis 2.527E-9 5.847E-8 4.286E-7 2.165E-6 4 41
37 GO:0035766 cell chemotaxis to fibroblast growth factor 2.729E-9 5.847E-8 4.286E-7 2.339E-6 3 7
38 GO:1904847 regulation of cell chemotaxis to fibroblast growth factor 2.729E-9 5.847E-8 4.286E-7 2.339E-6 3 7
39 GO:0035768 endothelial cell chemotaxis to fibroblast growth factor 2.729E-9 5.847E-8 4.286E-7 2.339E-6 3 7
40 GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor 2.729E-9 5.847E-8 4.286E-7 2.339E-6 3 7
41 GO:0007431 salivary gland development 3.385E-9 7.075E-8 5.187E-7 2.901E-6 4 44
42 GO:0022612 gland morphogenesis 4.301E-9 8.777E-8 6.434E-7 3.686E-6 5 153
43 GO:0060428 lung epithelium development 5.735E-9 1.143E-7 8.379E-7 4.915E-6 4 50
44 GO:0050673 epithelial cell proliferation 6.567E-9 1.279E-7 9.377E-7 5.628E-6 6 391
45 GO:0010632 regulation of epithelial cell migration 8.458E-9 1.576E-7 1.155E-6 7.248E-6 5 175
46 GO:0050679 positive regulation of epithelial cell proliferation 8.458E-9 1.576E-7 1.155E-6 7.248E-6 5 175
47 GO:0060688 regulation of morphogenesis of a branching structure 1.131E-8 2.063E-7 1.512E-6 9.694E-6 4 59
48 GO:0035272 exocrine system development 1.212E-8 2.163E-7 1.586E-6 1.038E-5 4 60
49 GO:0070374 positive regulation of ERK1 and ERK2 cascade 1.278E-8 2.203E-7 1.615E-6 1.096E-5 5 190
50 GO:0060693 regulation of branching involved in salivary gland morphogenesis 1.285E-8 2.203E-7 1.615E-6 1.101E-5 3 11
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 20 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031012 extracellular matrix 3.335E-5 6.671E-4 2.400E-3 6.671E-4 4 444
2 GO:0005938 cell cortex 6.547E-3 4.157E-2
1.496E-1
1.309E-1
 2 266
3 GO:0005614 interstitial matrix 7.531E-3 4.157E-2
1.496E-1
1.506E-1
 1 16
4 GO:0099568 cytoplasmic region 9.640E-3 4.157E-2
1.496E-1
1.928E-1
 2 325
5 GO:0005925 focal adhesion 1.387E-2 4.157E-2
1.496E-1
2.774E-1
 2 393
6 GO:0005924 cell-substrate adherens junction 1.421E-2 4.157E-2
1.496E-1
2.842E-1
 2 398
7 GO:0030055 cell-substrate junction 1.455E-2 4.157E-2
1.496E-1
2.910E-1
 2 403
Show 2 more annotations

4: Human Phenotype [Display Chart] 6 input genes in category / 1711 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0009659 Partial absence of thumb 1.151E-9 2.814E-7 2.258E-6 1.970E-6 3 3
2 HP:0007892 Hypoplasia of the lacrimal punctum 1.151E-9 2.814E-7 2.258E-6 1.970E-6 3 3
3 HP:0005707 Bilateral triphalangeal thumbs 1.151E-9 2.814E-7 2.258E-6 1.970E-6 3 3
4 HP:0009637 Absent proximal phalanx of thumb 1.151E-9 2.814E-7 2.258E-6 1.970E-6 3 3
5 HP:0009741 Nephrosclerosis 1.151E-9 2.814E-7 2.258E-6 1.970E-6 3 3
6 HP:0007656 Lacrimal gland aplasia 1.151E-9 2.814E-7 2.258E-6 1.970E-6 3 3
7 HP:0009740 Aplasia of the parotid gland 1.151E-9 2.814E-7 2.258E-6 1.970E-6 3 3
8 HP:0000198 Absence of Stensen duct 4.603E-9 9.845E-7 7.898E-6 7.876E-6 3 4
9 HP:0007732 Lacrimal gland hypoplasia 1.150E-8 1.312E-6 1.053E-5 1.968E-5 3 5
10 HP:0001245 Small thenar eminence 1.150E-8 1.312E-6 1.053E-5 1.968E-5 3 5
11 HP:0011479 Abnormal lacrimal punctum morphology 1.150E-8 1.312E-6 1.053E-5 1.968E-5 3 5
12 HP:0007900 Hypoplastic lacrimal duct 1.150E-8 1.312E-6 1.053E-5 1.968E-5 3 5
13 HP:0100583 Corneal perforation 1.150E-8 1.312E-6 1.053E-5 1.968E-5 3 5
14 HP:0001092 Absent lacrimal punctum 1.150E-8 1.312E-6 1.053E-5 1.968E-5 3 5
15 HP:0001227 Abnormality of the thenar eminence 1.150E-8 1.312E-6 1.053E-5 1.968E-5 3 5
16 HP:0010239 Aplasia of the middle phalanx of the hand 2.299E-8 1.874E-6 1.503E-5 3.934E-5 3 6
17 HP:0009462 Radial deviation of the 3rd finger 2.299E-8 1.874E-6 1.503E-5 3.934E-5 3 6
18 HP:0003795 Short middle phalanx of toe 2.299E-8 1.874E-6 1.503E-5 3.934E-5 3 6
19 HP:0008743 Coronal hypospadias 2.299E-8 1.874E-6 1.503E-5 3.934E-5 3 6
20 HP:0009629 Aplasia/Hypoplasia of the proximal phalanx of the thumb 2.299E-8 1.874E-6 1.503E-5 3.934E-5 3 6
21 HP:0011318 Bicoronal synostosis 2.299E-8 1.874E-6 1.503E-5 3.934E-5 3 6
22 HP:0009317 Deviation of the 3rd finger 4.022E-8 3.128E-6 2.510E-5 6.882E-5 3 7
23 HP:0001844 Abnormality of the hallux 5.128E-8 3.815E-6 3.061E-5 8.774E-5 5 117
24 HP:0009802 Aplasia of the phalanges of the hand 6.432E-8 3.931E-6 3.153E-5 1.101E-4 3 8
25 HP:0009618 Abnormality of the proximal phalanx of the thumb 6.432E-8 3.931E-6 3.153E-5 1.101E-4 3 8
26 HP:0001233 2-3 finger syndactyly 6.432E-8 3.931E-6 3.153E-5 1.101E-4 3 8
27 HP:0009823 Aplasia involving bones of the upper limbs 6.432E-8 3.931E-6 3.153E-5 1.101E-4 3 8
28 HP:0008038 Aplastic/hypoplastic lacrimal glands 6.432E-8 3.931E-6 3.153E-5 1.101E-4 3 8
29 HP:0010055 Broad hallux 8.113E-8 4.787E-6 3.840E-5 1.388E-4 4 42
30 HP:0002676 Cloverleaf skull 9.644E-8 5.258E-6 4.218E-5 1.650E-4 3 9
31 HP:0004150 Abnormal 3rd finger morphology 9.644E-8 5.258E-6 4.218E-5 1.650E-4 3 9
32 HP:0010051 Deviation of the hallux 9.833E-8 5.258E-6 4.218E-5 1.682E-4 4 44
33 HP:0000680 Delayed eruption of primary teeth 1.377E-7 7.083E-6 5.682E-5 2.356E-4 3 10
34 HP:0001837 Broad toe 1.408E-7 7.083E-6 5.682E-5 2.408E-4 4 48
35 HP:0004278 Synostosis involving bones of the hand 1.532E-7 7.490E-6 6.009E-5 2.621E-4 4 49
36 HP:0009944 Partial duplication of thumb phalanx 1.893E-7 8.752E-6 7.021E-5 3.238E-4 3 11
37 HP:0011065 Conical incisor 1.893E-7 8.752E-6 7.021E-5 3.238E-4 3 11
38 HP:0009843 Aplasia/Hypoplasia of the middle phalanges of the hand 2.115E-7 9.521E-6 7.638E-5 3.618E-4 4 53
39 HP:0011482 Abnormal lacrimal gland morphology 2.522E-7 1.079E-5 8.655E-5 4.315E-4 3 12
40 HP:0009999 Partial duplication of the phalanx of hand 2.522E-7 1.079E-5 8.655E-5 4.315E-4 3 12
41 HP:0009833 Abnormal middle phalanx morphology of the hand 2.650E-7 1.106E-5 8.870E-5 4.533E-4 4 56
42 HP:0009891 Underdeveloped supraorbital ridges 2.849E-7 1.133E-5 9.093E-5 4.874E-4 4 57
43 HP:0100498 Deviation of toes 2.849E-7 1.133E-5 9.093E-5 4.874E-4 4 57
44 HP:0003070 Elbow ankylosis 3.277E-7 1.246E-5 9.997E-5 5.607E-4 3 13
45 HP:0010183 Abnormality of the middle phalanges of the toes 3.277E-7 1.246E-5 9.997E-5 5.607E-4 3 13
46 HP:0031013 Ankylosis 5.209E-7 1.937E-5 1.554E-4 8.912E-4 3 15
47 HP:0000522 Alacrima 7.777E-7 2.831E-5 2.271E-4 1.331E-3 3 17
48 HP:0011063 Abnormality of incisor morphology 9.328E-7 3.325E-5 2.668E-4 1.596E-3 3 18
49 HP:0000614 Abnormal nasolacrimal system morphology 1.251E-6 4.367E-5 3.503E-4 2.140E-3 4 82
50 HP:0000633 Decreased lacrimation 1.302E-6 4.455E-5 3.574E-4 2.228E-3 3 20
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 9 input genes in category / 1340 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003855 abnormal forelimb zeugopod morphology 3.107E-8 4.163E-5 3.238E-4 4.163E-5 5 127
2 MP:0012085 midface hypoplasia 1.293E-7 4.590E-5 3.570E-4 1.733E-4 3 13
3 MP:0008273 abnormal intramembranous bone ossification 1.532E-7 4.590E-5 3.570E-4 2.053E-4 4 63
4 MP:0013550 abnormal secondary palate morphology 1.838E-7 4.590E-5 3.570E-4 2.464E-4 5 181
5 MP:0030229 abnormal craniofacial suture morphology 1.969E-7 4.590E-5 3.570E-4 2.638E-4 4 67
6 MP:0030065 face hypoplasia 2.055E-7 4.590E-5 3.570E-4 2.754E-4 3 15
7 MP:0006032 abnormal ureteric bud morphology 3.284E-7 5.624E-5 4.374E-4 4.400E-4 4 76
8 MP:0004573 absent limb buds 3.681E-7 5.624E-5 4.374E-4 4.933E-4 3 18
9 MP:0004831 long incisors 4.369E-7 5.624E-5 4.374E-4 5.855E-4 3 19
10 MP:0000550 abnormal forelimb morphology 4.755E-7 5.624E-5 4.374E-4 6.371E-4 5 219
11 MP:0030091 macrodontia 5.138E-7 5.624E-5 4.374E-4 6.885E-4 3 20
12 MP:0013766 absent palatal rugae 6.715E-7 5.624E-5 4.374E-4 8.999E-4 2 2
13 MP:0030434 premature maxillary-premaxillary suture closure 6.715E-7 5.624E-5 4.374E-4 8.999E-4 2 2
14 MP:0030390 premature facial suture closure 6.715E-7 5.624E-5 4.374E-4 8.999E-4 2 2
15 MP:0009510 cecal atresia 6.715E-7 5.624E-5 4.374E-4 8.999E-4 2 2
16 MP:0009479 abnormal cecum development 6.715E-7 5.624E-5 4.374E-4 8.999E-4 2 2
17 MP:0000552 abnormal radius morphology 9.942E-7 7.700E-5 5.989E-4 1.332E-3 4 100
18 MP:0000537 abnormal urethra morphology 1.034E-6 7.700E-5 5.989E-4 1.386E-3 3 25
19 MP:0030095 abnormal midface morphology 1.471E-6 9.006E-5 7.005E-4 1.972E-3 3 28
20 MP:0005358 abnormal incisor morphology 1.624E-6 9.006E-5 7.005E-4 2.177E-3 4 113
21 MP:0003416 premature bone ossification 1.640E-6 9.006E-5 7.005E-4 2.198E-3 3 29
22 MP:0000527 abnormal kidney development 1.867E-6 9.006E-5 7.005E-4 2.502E-3 4 117
23 MP:0009655 abnormal secondary palate development 1.999E-6 9.006E-5 7.005E-4 2.678E-3 4 119
24 MP:0010646 absent pulmonary vein 2.014E-6 9.006E-5 7.005E-4 2.698E-3 2 3
25 MP:0014051 abnormal maxillary-premaxillary suture morphology 2.014E-6 9.006E-5 7.005E-4 2.698E-3 2 3
26 MP:0030230 abnormal facial suture morphology 2.014E-6 9.006E-5 7.005E-4 2.698E-3 2 3
27 MP:0009509 absent rectum 2.014E-6 9.006E-5 7.005E-4 2.698E-3 2 3
28 MP:0013582 abnormal lateral nasal gland morphology 2.014E-6 9.006E-5 7.005E-4 2.698E-3 2 3
29 MP:0010521 absent pulmonary artery 2.014E-6 9.006E-5 7.005E-4 2.698E-3 2 3
30 MP:0001300 ocular hypertelorism 2.016E-6 9.006E-5 7.005E-4 2.702E-3 3 31
31 MP:0003854 abnormal forelimb stylopod morphology 2.281E-6 9.862E-5 7.670E-4 3.057E-3 4 123
32 MP:0009653 abnormal palate development 2.357E-6 9.868E-5 7.675E-4 3.158E-3 4 124
33 MP:0003630 abnormal urothelium morphology 2.445E-6 9.929E-5 7.723E-4 3.277E-3 3 33
34 MP:0030064 small face 2.931E-6 1.155E-4 8.984E-4 3.927E-3 3 35
35 MP:0011025 abnormal branching involved in trachea morphogenesis 4.026E-6 1.303E-4 1.014E-3 5.394E-3 2 4
36 MP:0013721 abnormal mammary placode morphology 4.026E-6 1.303E-4 1.014E-3 5.394E-3 2 4
37 MP:0009525 abnormal submandibular duct morphology 4.026E-6 1.303E-4 1.014E-3 5.394E-3 2 4
38 MP:0010979 small ureteric bud 4.026E-6 1.303E-4 1.014E-3 5.394E-3 2 4
39 MP:0013264 tongue ankylosis 4.026E-6 1.303E-4 1.014E-3 5.394E-3 2 4
40 MP:0011485 abnormal urethra urothelium morphology 4.026E-6 1.303E-4 1.014E-3 5.394E-3 2 4
41 MP:0010975 abnormal lung lobe morphology 4.085E-6 1.303E-4 1.014E-3 5.474E-3 3 39
42 MP:0030063 abnormal face size 4.085E-6 1.303E-4 1.014E-3 5.474E-3 3 39
43 MP:0003755 abnormal palate morphology 4.189E-6 1.306E-4 1.015E-3 5.614E-3 5 340
44 MP:0004194 abnormal kidney pelvis morphology 4.524E-6 1.378E-4 1.072E-3 6.062E-3 4 146
45 MP:0030878 abnormal fibrous joint morphology 4.648E-6 1.384E-4 1.077E-3 6.229E-3 4 147
46 MP:0004471 short nasal bone 4.761E-6 1.387E-4 1.079E-3 6.379E-3 3 41
47 MP:0003942 abnormal urinary system development 5.038E-6 1.431E-4 1.113E-3 6.751E-3 4 150
48 MP:0006027 impaired lung alveolus development 5.125E-6 1.431E-4 1.113E-3 6.867E-3 3 42
49 MP:0009890 cleft secondary palate 6.195E-6 1.590E-4 1.237E-3 8.302E-3 4 158
50 MP:0014139 abnormal ectoderm morphology 6.326E-6 1.590E-4 1.237E-3 8.477E-3 3 45
Show 45 more annotations

6: Domain [Display Chart] 9 input genes in category / 61 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00167 FGF Pfam 1.789E-10 2.642E-9 1.241E-8 1.091E-8 4 22
2 IPR002209 Fibroblast GF fam InterPro 1.789E-10 2.642E-9 1.241E-8 1.091E-8 4 22
3 SM00442 FGF SMART 1.789E-10 2.642E-9 1.241E-8 1.091E-8 4 22
4 PS00247 HBGF FGF PROSITE 1.789E-10 2.642E-9 1.241E-8 1.091E-8 4 22
5 IPR028142 IL-1 fam/FGF fam InterPro 2.165E-10 2.642E-9 1.241E-8 1.321E-8 4 23
6 IPR016248 FGF rcpt fam InterPro 3.065E-10 3.117E-9 1.464E-8 1.870E-8 3 4
7 IPR008996 Cytokine IL1-like InterPro 1.436E-9 1.252E-8 5.879E-8 8.762E-8 4 36
8 SM00219 TyrKc SMART 8.242E-6 5.586E-5 2.623E-4 5.027E-4 3 88
9 IPR020635 Tyr kinase cat dom InterPro 8.242E-6 5.586E-5 2.623E-4 5.027E-4 3 88
10 PS00109 PROTEIN KINASE TYR PROSITE 1.105E-5 6.127E-5 2.878E-4 6.740E-4 3 97
11 IPR008266 Tyr kinase AS InterPro 1.105E-5 6.127E-5 2.878E-4 6.740E-4 3 97
12 PF07714 Pkinase Tyr Pfam 2.599E-5 1.321E-4 6.205E-4 1.585E-3 3 129
13 IPR001245 Ser-Thr/Tyr kinase cat dom InterPro 3.180E-5 1.492E-4 7.007E-4 1.940E-3 3 138
14 IPR013098 Ig I-set InterPro 8.245E-5 3.353E-4 1.575E-3 5.030E-3 3 190
15 PF07679 I-set Pfam 8.245E-5 3.353E-4 1.575E-3 5.030E-3 3 190
16 IPR003598 Ig sub2 InterPro 1.548E-4 5.554E-4 2.608E-3 9.442E-3 3 235
17 SM00408 IGc2 SMART 1.548E-4 5.554E-4 2.608E-3 9.442E-3 3 235
18 IPR028252 FGF10 InterPro 4.804E-4 1.274E-3 5.983E-3 2.930E-2 1 1
19 IPR033078 TNC InterPro 4.804E-4 1.274E-3 5.983E-3 2.930E-2 1 1
20 IPR028289 FGF18 InterPro 4.804E-4 1.274E-3 5.983E-3 2.930E-2 1 1
21 IPR028210 FGF1 InterPro 4.804E-4 1.274E-3 5.983E-3 2.930E-2 1 1
22 IPR028247 FGF7 InterPro 4.804E-4 1.274E-3 5.983E-3 2.930E-2 1 1
23 IPR028174 FGF rcpt 1 InterPro 4.804E-4 1.274E-3 5.983E-3 2.930E-2 1 1
24 IPR017441 Protein kinase ATP BS InterPro 6.301E-4 1.602E-3 7.521E-3 3.844E-2 3 379
25 SM00409 IG SMART 8.556E-4 2.007E-3 9.427E-3
5.219E-2
 3 421
26 IPR003599 Ig sub InterPro 8.556E-4 2.007E-3 9.427E-3
5.219E-2
 3 421
27 PS00107 PROTEIN KINASE ATP PROSITE 1.099E-3 2.484E-3 1.166E-2
6.706E-2
 3 459
28 IPR000719 Prot kinase dom InterPro 1.320E-3 2.748E-3 1.291E-2
8.053E-2
 3 489
29 PS50835 IG LIKE PROSITE 1.344E-3 2.748E-3 1.291E-2
8.196E-2
 3 492
30 PS50011 PROTEIN KINASE DOM PROSITE 1.352E-3 2.748E-3 1.291E-2
8.244E-2
 3 493
31 PF00047 ig Pfam 3.515E-3 6.700E-3 3.146E-2
2.144E-1
 2 190
32 IPR013151 Immunoglobulin InterPro 3.515E-3 6.700E-3 3.146E-2
2.144E-1
 2 190
33 IPR014715 Fibrinogen a/b/g C 2 InterPro 1.147E-2 2.058E-2
9.667E-2
6.998E-1
 1 24
34 4.10.530.10 - Gene3D 1.147E-2 2.058E-2
9.667E-2
6.998E-1
 1 24
35 PF00147 Fibrinogen C Pfam 1.290E-2 2.248E-2
1.056E-1
7.868E-1
 1 27
36 SM00186 FBG SMART 1.385E-2 2.272E-2
1.067E-1
8.447E-1
 1 29
37 3.90.215.10 - Gene3D 1.432E-2 2.272E-2
1.067E-1
8.737E-1
 1 30
38 IPR014716 Fibrinogen a/b/g C 1 InterPro 1.432E-2 2.272E-2
1.067E-1
8.737E-1
 1 30
39 PS00514 FIBRINOGEN C 1 PROSITE 1.527E-2 2.272E-2
1.067E-1
9.315E-1
 1 32
40 PS51406 FIBRINOGEN C 2 PROSITE 1.527E-2 2.272E-2
1.067E-1
9.315E-1
 1 32
41 IPR002181 Fibrinogen a/b/g C dom InterPro 1.527E-2 2.272E-2
1.067E-1
9.315E-1
 1 32
42 PF07974 EGF 2 Pfam 2.846E-2 4.038E-2
1.896E-1
1.000E0
 1 60
43 IPR013111 EGF extracell InterPro 2.846E-2 4.038E-2
1.896E-1
1.000E0
 1 60
Show 38 more annotations

7: Pathway [Display Chart] 9 input genes in category / 150 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1268863 Signaling by FGFR in disease BioSystems: REACTOME 2.152E-15 2.030E-13 1.135E-12 3.228E-13 7 63
2 1268880 Constitutive Signaling by Aberrant PI3K in Cancer BioSystems: REACTOME 2.707E-15 2.030E-13 1.135E-12 4.060E-13 7 65
3 1269432 PI3K Cascade BioSystems: REACTOME 1.233E-14 6.163E-13 3.446E-12 1.849E-12 7 80
4 1383020 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling BioSystems: REACTOME 2.265E-14 7.237E-13 4.046E-12 3.397E-12 7 87
5 1269386 Signaling by FGFR BioSystems: REACTOME 2.670E-14 7.237E-13 4.046E-12 4.005E-12 7 89
6 1268879 PI3K/AKT Signaling in Cancer BioSystems: REACTOME 2.895E-14 7.237E-13 4.046E-12 4.342E-12 7 90
7 1269191 Negative regulation of the PI3K/AKT network BioSystems: REACTOME 3.963E-14 8.493E-13 4.749E-12 5.945E-12 7 94
8 P00021 FGF signaling pathway PantherDB 7.143E-14 1.339E-12 7.488E-12 1.071E-11 7 102
9 1269188 PIP3 activates AKT signaling BioSystems: REACTOME 3.074E-13 4.553E-12 2.546E-11 4.611E-11 7 125
10 1268871 Activated point mutants of FGFR2 BioSystems: REACTOME 3.120E-13 4.553E-12 2.546E-11 4.681E-11 5 17
11 1269384 GAB1 signalosome BioSystems: REACTOME 3.643E-13 4.553E-12 2.546E-11 5.464E-11 7 128
12 1269473 PI3K/AKT activation BioSystems: REACTOME 3.643E-13 4.553E-12 2.546E-11 5.464E-11 7 128
13 1269405 Phospholipase C-mediated cascade; FGFR2 BioSystems: REACTOME 4.319E-13 4.984E-12 2.787E-11 6.479E-11 5 18
14 1269302 Role of LAT2/NTAL/LAB on calcium mobilization BioSystems: REACTOME 5.919E-13 6.342E-12 3.546E-11 8.879E-11 7 137
15 1269400 FGFR2 ligand binding and activation BioSystems: REACTOME 7.812E-13 7.812E-12 4.368E-11 1.172E-10 5 20
16 1269406 SHC-mediated cascade:FGFR2 BioSystems: REACTOME 1.694E-12 1.495E-11 8.358E-11 2.541E-10 5 23
17 1269407 PI-3K cascade:FGFR2 BioSystems: REACTOME 1.694E-12 1.495E-11 8.358E-11 2.541E-10 5 23
18 692234 PI3K-Akt signaling pathway BioSystems: KEGG 2.629E-12 2.111E-11 1.180E-10 3.943E-10 8 342
19 1269404 FRS-mediated FGFR2 signaling BioSystems: REACTOME 2.673E-12 2.111E-11 1.180E-10 4.010E-10 5 25
20 1269403 Downstream signaling of activated FGFR2 BioSystems: REACTOME 7.161E-12 5.371E-11 3.003E-10 1.074E-9 5 30
21 1269185 Downstream signaling events of B Cell Receptor (BCR) BioSystems: REACTOME 8.408E-12 6.006E-11 3.358E-10 1.261E-9 7 199
22 1268870 FGFR2 mutant receptor activation BioSystems: REACTOME 1.192E-11 8.024E-11 4.486E-10 1.788E-9 5 33
23 868086 Rap1 signaling pathway BioSystems: KEGG 1.230E-11 8.024E-11 4.486E-10 1.845E-9 7 210
24 83089 Regulation of actin cytoskeleton BioSystems: KEGG 1.316E-11 8.222E-11 4.597E-10 1.973E-9 7 212
25 1269408 Negative regulation of FGFR2 signaling BioSystems: REACTOME 1.397E-11 8.381E-11 4.686E-10 2.095E-9 5 34
26 868085 Ras signaling pathway BioSystems: KEGG 2.133E-11 1.230E-10 6.879E-10 3.199E-9 7 227
27 1269401 FGFR2b ligand binding and activation BioSystems: REACTOME 2.639E-11 1.466E-10 8.198E-10 3.959E-9 4 10
28 1269183 Signaling by the B Cell Receptor (BCR) BioSystems: REACTOME 2.806E-11 1.503E-10 8.406E-10 4.209E-9 7 236
29 1269382 GRB2 events in EGFR signaling BioSystems: REACTOME 3.982E-11 1.863E-10 1.042E-9 5.973E-9 7 248
30 1269440 SOS-mediated signalling BioSystems: REACTOME 3.982E-11 1.863E-10 1.042E-9 5.973E-9 7 248
31 1269383 SHC1 events in EGFR signaling BioSystems: REACTOME 3.982E-11 1.863E-10 1.042E-9 5.973E-9 7 248
32 1269285 RAF/MAP kinase cascade BioSystems: REACTOME 3.982E-11 1.863E-10 1.042E-9 5.973E-9 7 248
33 1269471 ARMS-mediated activation BioSystems: REACTOME 4.457E-11 1.863E-10 1.042E-9 6.686E-9 7 252
34 1269468 Signalling to p38 via RIT and RIN BioSystems: REACTOME 4.457E-11 1.863E-10 1.042E-9 6.686E-9 7 252
35 1269470 Frs2-mediated activation BioSystems: REACTOME 4.583E-11 1.863E-10 1.042E-9 6.875E-9 7 253
36 1269502 MAPK1/MAPK3 signaling BioSystems: REACTOME 4.713E-11 1.863E-10 1.042E-9 7.069E-9 7 254
37 1268869 Signaling by FGFR2 in disease BioSystems: REACTOME 4.820E-11 1.863E-10 1.042E-9 7.230E-9 5 43
38 1269469 Prolonged ERK activation events BioSystems: REACTOME 4.845E-11 1.863E-10 1.042E-9 7.267E-9 7 255
39 83048 MAPK signaling pathway BioSystems: KEGG 4.845E-11 1.863E-10 1.042E-9 7.267E-9 7 255
40 1269632 Signaling by Leptin BioSystems: REACTOME 4.980E-11 1.868E-10 1.044E-9 7.470E-9 7 256
41 1269322 Interleukin receptor SHC signaling BioSystems: REACTOME 5.261E-11 1.925E-10 1.076E-9 7.892E-9 7 258
42 1269465 Signalling to RAS BioSystems: REACTOME 5.406E-11 1.931E-10 1.080E-9 8.110E-9 7 259
43 1269485 VEGFR2 mediated cell proliferation BioSystems: REACTOME 5.707E-11 1.991E-10 1.113E-9 8.561E-9 7 261
44 1269321 Interleukin-2 signaling BioSystems: REACTOME 6.353E-11 2.166E-10 1.211E-9 9.529E-9 7 265
45 1269464 Signalling to ERKs BioSystems: REACTOME 6.524E-11 2.175E-10 1.216E-9 9.785E-9 7 266
46 1427866 RET signaling BioSystems: REACTOME 7.833E-11 2.512E-10 1.404E-9 1.175E-8 7 273
47 1269323 Interleukin-3, 5 and GM-CSF signaling BioSystems: REACTOME 8.037E-11 2.512E-10 1.404E-9 1.206E-8 7 274
48 1269299 FCERI mediated MAPK activation BioSystems: REACTOME 8.037E-11 2.512E-10 1.404E-9 1.206E-8 7 274
49 1270312 NCAM signaling for neurite out-growth BioSystems: REACTOME 9.128E-11 2.794E-10 1.562E-9 1.369E-8 7 279
50 1269501 MAPK family signaling cascades BioSystems: REACTOME 1.288E-10 3.864E-10 2.160E-9 1.932E-8 7 293
Show 45 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 4116 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10579907 Phospholipase C-gamma as a signal-transducing element. Pubmed 1.780E-22 5.147E-19 4.581E-18 7.325E-19 7 21
2 11165488 Expression of members of the Fgf family and their receptors during midfacial development. Pubmed 2.610E-22 5.147E-19 4.581E-18 1.074E-18 7 22
3 21223962 The function of FGF signaling in the lens placode. Pubmed 3.752E-22 5.147E-19 4.581E-18 1.544E-18 7 23
4 19544582 Fibroblast growth factor (FGF) gene expression in the developing cerebellum suggests multiple roles for FGF signaling during cerebellar morphogenesis and development. Pubmed 7.355E-22 7.569E-19 6.736E-18 3.027E-18 7 25
5 20348033 Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse. Pubmed 1.006E-21 8.285E-19 7.374E-18 4.143E-18 7 26
6 16123981 Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform. Pubmed 2.388E-21 1.404E-18 1.250E-17 9.828E-18 7 29
7 21876757 FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system. Pubmed 2.388E-21 1.404E-18 1.250E-17 9.828E-18 7 29
8 24198358 A local source of FGF initiates development of the unmyelinated lineage of sensory neurons. Pubmed 2.851E-20 1.467E-17 1.305E-16 1.173E-16 7 40
9 27046834 An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium. Pubmed 5.851E-20 2.676E-17 2.381E-16 2.408E-16 6 14
10 11731698 Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Pubmed 1.560E-19 6.421E-17 5.714E-16 6.421E-16 6 16
11 15963767 Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Pubmed 1.769E-19 6.621E-17 5.892E-16 7.283E-16 7 51
12 12666204 Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Pubmed 5.900E-19 2.024E-16 1.801E-15 2.428E-15 7 60
13 12421715 Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. Pubmed 7.548E-19 2.390E-16 2.127E-15 3.107E-15 6 20
14 11294897 Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Pubmed 3.448E-18 1.014E-15 9.021E-15 1.419E-14 6 25
15 25721301 Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine. Pubmed 1.042E-17 2.859E-15 2.544E-14 4.288E-14 5 8
16 23133671 Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis. Pubmed 2.344E-17 5.675E-15 5.051E-14 9.648E-14 5 9
17 11335076 The expression of fibroblast growth factors and their receptors in the embryonic and neonatal mouse inner ear. Pubmed 2.344E-17 5.675E-15 5.051E-14 9.648E-14 5 9
18 8585128 Fibroblast-growth-factor receptor mutations in human skeletal disorders. Pubmed 1.473E-16 3.368E-14 2.998E-13 6.063E-13 5 12
19 8883961 Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development. Pubmed 2.393E-16 4.478E-14 3.985E-13 9.851E-13 5 13
20 9385055 A quantitative method for evaluation of FGF family and FGF receptor family gene expression by RT-PCR. Pubmed 2.393E-16 4.478E-14 3.985E-13 9.851E-13 5 13
21 8663044 Receptor specificity of the fibroblast growth factor family. Pubmed 2.393E-16 4.478E-14 3.985E-13 9.851E-13 5 13
22 16151852 Apoptosis, proliferation and gene expression patterns in mouse developing tongue. Pubmed 2.393E-16 4.478E-14 3.985E-13 9.851E-13 5 13
23 17133345 Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells. Pubmed 3.723E-16 6.662E-14 5.929E-13 1.532E-12 5 14
24 26453795 BCL11B regulates sutural patency in the mouse craniofacial skeleton. Pubmed 8.121E-16 1.393E-13 1.240E-12 3.343E-12 5 16
25 16597617 Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. Pubmed 2.161E-15 3.558E-13 3.167E-12 8.896E-12 5 19
26 28818950 Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice. Pubmed 3.782E-15 5.987E-13 5.328E-12 1.557E-11 5 21
27 14517998 Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development. Pubmed 6.252E-15 8.863E-13 7.888E-12 2.573E-11 5 23
28 27206683 Efficient regulation of branching morphogenesis via fibroblast growth factor receptor 2c in early-stage embryonic mouse salivary glands. Pubmed 7.106E-15 8.863E-13 7.888E-12 2.925E-11 4 5
29 11714710 Differential effects of heparin saccharides on the formation of specific fibroblast growth factor (FGF) and FGF receptor complexes. Pubmed 7.106E-15 8.863E-13 7.888E-12 2.925E-11 4 5
30 8576175 Expression and biological activity of mouse fibroblast growth factor-9. Pubmed 7.106E-15 8.863E-13 7.888E-12 2.925E-11 4 5
31 17360555 Impaired FGF signaling contributes to cleft lip and palate. Pubmed 7.106E-15 8.863E-13 7.888E-12 2.925E-11 4 5
32 22955284 Nectin-1 binds and signals through the fibroblast growth factor receptor. Pubmed 7.106E-15 8.863E-13 7.888E-12 2.925E-11 4 5
33 16091423 Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors. Pubmed 7.106E-15 8.863E-13 7.888E-12 2.925E-11 4 5
34 21655085 FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. Pubmed 7.897E-15 9.560E-13 8.508E-12 3.250E-11 5 24
35 14602678 FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. Pubmed 2.132E-14 2.507E-12 2.231E-11 8.774E-11 4 6
36 27770432 Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia. Pubmed 3.155E-14 3.607E-12 3.210E-11 1.299E-10 5 31
37 11782400 Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Pubmed 4.973E-14 5.532E-12 4.924E-11 2.047E-10 4 7
38 17196193 FGF10 signaling controls stomach morphogenesis. Pubmed 6.997E-14 7.579E-12 6.745E-11 2.880E-10 5 36
39 19218784 Differential FGF ligands and FGF receptors expression pattern in frontal and parietal calvarial bones. Pubmed 9.946E-14 1.023E-11 9.108E-11 4.094E-10 4 8
40 18187602 betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Pubmed 9.946E-14 1.023E-11 9.108E-11 4.094E-10 4 8
41 15830353 Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse. Pubmed 1.790E-13 1.754E-11 1.561E-10 7.368E-10 4 9
42 17090159 Developmentally regulated expression of MSX1, MSX2 and Fgfs in the developing mouse cranial base. Pubmed 1.790E-13 1.754E-11 1.561E-10 7.368E-10 4 9
43 15340846 Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptors. Pubmed 2.983E-13 2.729E-11 2.428E-10 1.228E-9 4 10
44 15470137 Laminar patterning in the developing neocortex by temporally coordinated fibroblast growth factor signaling. Pubmed 2.983E-13 2.729E-11 2.428E-10 1.228E-9 4 10
45 1697263 Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. Pubmed 2.983E-13 2.729E-11 2.428E-10 1.228E-9 4 10
46 11937494 FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Pubmed 4.687E-13 3.937E-11 3.504E-10 1.929E-9 4 11
47 8901049 Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle. Pubmed 4.687E-13 3.937E-11 3.504E-10 1.929E-9 4 11
48 15108315 Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis. Pubmed 4.687E-13 3.937E-11 3.504E-10 1.929E-9 4 11
49 18199118 Fibroblast growth factor-derived peptides: functional agonists of the fibroblast growth factor receptor. Pubmed 4.687E-13 3.937E-11 3.504E-10 1.929E-9 4 11
50 21750042 FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium. Pubmed 7.030E-13 5.674E-11 5.050E-10 2.894E-9 4 12
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 384 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:FGFR2 FGFR2 interactions 5.287E-15 2.030E-12 1.326E-11 2.030E-12 7 100
2 int:FGF18 FGF18 interactions 4.618E-13 8.866E-11 5.789E-10 1.773E-10 4 6
3 int:FGF7 FGF7 interactions 4.194E-11 5.368E-9 3.505E-8 1.610E-8 4 15
4 int:FGFR3 FGFR3 interactions 7.106E-11 5.975E-9 3.901E-8 2.729E-8 5 65
5 int:FGFR1 FGFR1 interactions 7.780E-11 5.975E-9 3.901E-8 2.988E-8 6 178
6 int:FGF1 FGF1 interactions 6.272E-10 4.014E-8 2.621E-7 2.408E-7 4 28
7 int:FGF6 FGF6 interactions 9.081E-10 4.359E-8 2.846E-7 3.487E-7 3 5
8 int:FGF17 FGF17 interactions 9.081E-10 4.359E-8 2.846E-7 3.487E-7 3 5
9 int:FGF23 FGF23 interactions 1.816E-9 6.973E-8 4.553E-7 6.973E-7 3 6
10 int:FGF4 FGF4 interactions 1.816E-9 6.973E-8 4.553E-7 6.973E-7 3 6
11 int:KL KL interactions 3.177E-9 8.714E-8 5.689E-7 1.220E-6 3 7
12 int:KLB KLB interactions 3.177E-9 8.714E-8 5.689E-7 1.220E-6 3 7
13 int:FGF5 FGF5 interactions 3.177E-9 8.714E-8 5.689E-7 1.220E-6 3 7
14 int:ANOS1 ANOS1 interactions 3.177E-9 8.714E-8 5.689E-7 1.220E-6 3 7
15 int:FGFBP1 FGFBP1 interactions 7.620E-9 1.951E-7 1.274E-6 2.926E-6 3 9
16 int:FGF10 FGF10 interactions 1.496E-8 3.591E-7 2.344E-6 5.745E-6 3 11
17 int:NECTIN1 NECTIN1 interactions 3.298E-8 7.450E-7 4.864E-6 1.266E-5 3 14
18 int:FGF9 FGF9 interactions 4.121E-8 8.792E-7 5.741E-6 1.583E-5 3 15
19 int:FGF2 FGF2 interactions 1.110E-6 2.243E-5 1.465E-4 4.262E-4 3 43
20 int:EPHA4 EPHA4 interactions 2.102E-6 4.035E-5 2.634E-4 8.070E-4 3 53
21 int:FGF3 FGF3 interactions 3.222E-6 5.892E-5 3.847E-4 1.237E-3 3 61
22 int:NRP1 NRP1 interactions 3.385E-6 5.908E-5 3.858E-4 1.300E-3 3 62
23 int:RPS6KA3 RPS6KA3 interactions 7.047E-6 1.128E-4 7.362E-4 2.706E-3 3 79
24 int:TMEM30B TMEM30B interactions 7.047E-6 1.128E-4 7.362E-4 2.706E-3 3 79
25 int:SDC2 SDC2 interactions 1.152E-5 1.770E-4 1.156E-3 4.425E-3 3 93
26 int:FGFR4 FGFR4 interactions 1.308E-5 1.932E-4 1.261E-3 5.022E-3 3 97
27 int:FGF8 FGF8 interactions 1.521E-5 2.163E-4 1.413E-3 5.841E-3 3 102
28 int:RAET1E RAET1E interactions 4.345E-5 5.958E-4 3.890E-3 1.668E-2 2 20
29 int:TGFBR3 TGFBR3 interactions 1.131E-4 1.497E-3 9.775E-3 4.342E-2 2 32
30 int:FRS2 FRS2 interactions 1.516E-4 1.941E-3 1.267E-2
5.822E-2
 2 37
31 int:LITAF LITAF interactions 2.351E-4 2.912E-3 1.901E-2
9.026E-2
 2 46
32 int:ITGA5 ITGA5 interactions 2.779E-4 3.335E-3 2.177E-2
1.067E-1
 2 50
33 int:TSPAN3 TSPAN3 interactions 3.243E-4 3.774E-3 2.464E-2
1.245E-1
 2 54
34 int:STAT3 STAT3 interactions 3.826E-4 4.321E-3 2.821E-2
1.469E-1
 3 302
35 int:FCGRT FCGRT interactions 4.005E-4 4.394E-3 2.869E-2
1.538E-1
 2 60
36 int:RPS6KA1 RPS6KA1 interactions 1.001E-3 1.033E-2
6.743E-2
3.844E-1
 2 95
37 int:TCF23 TCF23 interactions 1.017E-3 1.033E-2
6.743E-2
3.904E-1
 1 2
38 int:PTK2B PTK2B interactions 1.022E-3 1.033E-2
6.743E-2
3.925E-1
 2 96
39 int:STAT5A STAT5A interactions 1.387E-3 1.366E-2
8.919E-2
5.327E-1
 2 112
40 int:SLC25A6 SLC25A6 interactions 1.948E-3 1.763E-2
1.151E-1
7.481E-1
 2 133
41 int:FLRT3 FLRT3 interactions 2.032E-3 1.763E-2
1.151E-1
7.804E-1
 1 4
42 int:FLRT2 FLRT2 interactions 2.032E-3 1.763E-2
1.151E-1
7.804E-1
 1 4
43 int:GOLGA7B GOLGA7B interactions 2.032E-3 1.763E-2
1.151E-1
7.804E-1
 1 4
44 int:IFFO2 IFFO2 interactions 2.032E-3 1.763E-2
1.151E-1
7.804E-1
 1 4
45 int:CD44 CD44 interactions 2.065E-3 1.763E-2
1.151E-1
7.932E-1
 2 137
46 int:CRKL CRKL interactions 2.186E-3 1.825E-2
1.191E-1
8.394E-1
 2 141
47 int:CLDN10 CLDN10 interactions 2.540E-3 1.840E-2
1.201E-1
9.752E-1
 1 5
48 int:LYSMD1 LYSMD1 interactions 2.540E-3 1.840E-2
1.201E-1
9.752E-1
 1 5
49 int:C6orf47 C6orf47 interactions 2.540E-3 1.840E-2
1.201E-1
9.752E-1
 1 5
50 int:CCDC17 CCDC17 interactions 2.540E-3 1.840E-2
1.201E-1
9.752E-1
 1 5
Show 45 more annotations

10: Cytoband [Display Chart] 9 input genes in category / 9 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5p13-p12 5p13-p12 7.788E-4 7.009E-3 1.983E-2 7.009E-3 1 3
2 9q33 9q33 2.076E-3 8.559E-3 2.421E-2 1.868E-2 1 8
3 15q21 15q21 2.853E-3 8.559E-3 2.421E-2 2.568E-2 1 11
4 10q26 10q26 5.957E-3 1.281E-2 3.623E-2
5.361E-2
 1 23
5 15q21.2 15q21.2 7.506E-3 1.281E-2 3.623E-2
6.755E-2
 1 29
6 5q34 5q34 8.537E-3 1.281E-2 3.623E-2
7.683E-2
 1 33
7 8p12 8p12 1.265E-2 1.627E-2 4.602E-2
1.139E-1
 1 49
8 4p16.3 4p16.3 2.338E-2 2.631E-2
7.442E-2
2.105E-1
 1 91
9 5q31 5q31 2.947E-2 2.947E-2
8.337E-2
2.652E-1
 1 115
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 141 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$RP58 01 V$RP58 01 3.600E-4 1.034E-2
5.717E-2
5.076E-2
 3 187
2 WCAANNNYCAG UNKNOWN WCAANNNYCAG UNKNOWN 3.891E-4 1.034E-2
5.717E-2
5.486E-2
 3 192
3 V$BRN2 01 V$BRN2 01 4.196E-4 1.034E-2
5.717E-2
5.917E-2
 3 197
4 V$NKX25 02 V$NKX25 02 4.785E-4 1.034E-2
5.717E-2
6.746E-2
 3 206
5 V$TAL1BETAE47 01 V$TAL1BETAE47 01 4.922E-4 1.034E-2
5.717E-2
6.940E-2
 3 208
6 V$CDPCR3 01 V$CDPCR3 01 4.970E-4 1.034E-2
5.717E-2
7.007E-2
 2 42
7 V$OSF2 Q6 V$OSF2 Q6 5.133E-4 1.034E-2
5.717E-2
7.238E-2
 3 211
8 CATTGTYY V$SOX9 B1 CATTGTYY V$SOX9 B1 1.337E-3 2.356E-2
1.303E-1
1.885E-1
 3 293
9 V$COMP1 01 V$COMP1 01 2.627E-3 4.116E-2
2.276E-1
3.705E-1
 2 97
Show 4 more annotations

12: Gene Family [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 321 Receptor Tyrosine Kinases|Protein phosphatase 1 regulatory subunits genenames.org 3.425E-7 2.397E-6 6.216E-6 2.397E-6 3 40
2 593 Fibronectin type III domain containing|I-set domain containing|Immunoglobulin like domain containing genenames.org 2.319E-5 8.117E-5 2.105E-4 1.623E-4 3 161
3 471 CD molecules|Tumor necrosis factor superfamily genenames.org 3.306E-4 7.715E-4 2.000E-3 2.314E-3 3 394
4 542 Endogenous ligands genenames.org 3.399E-3 5.948E-3 1.542E-2 2.379E-2 2 237
5 554 Fibrinogen C domain containing|Fibronectin type III domain containing genenames.org 9.581E-3 1.341E-2 3.478E-2
6.706E-2
 1 25
6 420 Basic helix-loop-helix proteins genenames.org 4.157E-2 4.850E-2
1.257E-1
2.910E-1
 1 110
Show 1 more annotation

13: Coexpression [Display Chart] 9 input genes in category / 1136 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15696083-Table1 Human Lung Wang05 64genes GeneSigDB 4.131E-9 4.693E-6 3.573E-5 4.693E-6 4 57
2 17295094-GeneList Human Breast VandenEynden07 269genes-hypoxia angiogenesis GeneSigDB 2.218E-8 1.260E-5 9.591E-5 2.520E-5 5 263
3 21205295-TableS2 Mouse Viral Buonomo11 116genes GeneSigDB 4.958E-8 1.532E-5 1.166E-4 5.632E-5 4 105
4 M1368 Predicted targets of SOX9 [GeneID=6662] that are up-regulated during early prostate development. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.394E-8 1.532E-5 1.166E-4 6.127E-5 3 21
5 20042535-TableS2b Human InVitro Haouzi10 24genes GeneSigDB 7.179E-8 1.631E-5 1.242E-4 8.156E-5 3 23
6 18435859-ShorterGeneList Mouse Breast Piechocki08 558genes GeneSigDB 1.318E-7 2.496E-5 1.900E-4 1.498E-4 5 376
7 20460173-ImmPortCytokines Human Immune Kong10 456genes ImmPort Cytokines GeneSigDB 2.657E-7 4.312E-5 3.283E-4 3.019E-4 5 433
8 M12112 Angiogenic markers up-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus). MSigDB C2: CGP Curated Gene Sets (v6.0) 3.056E-7 4.340E-5 3.304E-4 3.472E-4 4 165
9 16585153-Table1 Mouse Skin Hagendoorn06 54genes GeneSigDB 8.909E-7 1.124E-4 8.561E-4 1.012E-3 3 52
10 14583454-TableS1 Human Brain Godard03 239genes GeneSigDB 1.075E-6 1.221E-4 9.296E-4 1.221E-3 4 226
11 M17937 Top 100 probe sets contrubuting to the negative side of the 1st principal component; predominantly associated with synovial sarcoma and myxoid/round cell liposarcoma samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.602E-6 2.687E-4 2.046E-3 2.956E-3 3 74
12 M17183 Set 'Oct4 targets': genes upregulated and identified by ChIP on chip as OCT4 [GeneID=5460] transcription factor targets in human embryonic stem cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.899E-6 2.744E-4 2.089E-3 3.293E-3 4 290
13 18234966-Table2 Mouse Ovarian Wang07 85genes GeneSigDB 3.682E-6 3.217E-4 2.449E-3 4.182E-3 3 83
14 M9150 Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.445E-6 3.607E-4 2.746E-3 5.050E-3 4 323
15 14993899-TableS1 Human Futreal04 427genes ConsensusCancerGenes GeneSigDB 7.133E-6 5.402E-4 4.113E-3 8.104E-3 4 364
16 M12828 Genes up-regulated in reverted NIH3T3 cells (fibroblasts transformed by activated KRAS [GeneID=3845] which then reverted to normal cells upon stable over-expression of a dominant negative form of CDC25 [GeneID=5923]) vs normal fibroblasts. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.117E-5 7.932E-4 6.039E-3 1.269E-2 3 120
17 16488994-SuppTable1b Mouse Lung Lu06 856genes Array MEO430Av2 GeneSigDB 1.548E-5 9.591E-4 7.302E-3 1.759E-2 4 443
18 19597962-Table3 Mouse Colon Liu10 17genes GeneSigDB 1.610E-5 9.591E-4 7.302E-3 1.828E-2 2 16
19 16488994-SuppTable1a Mouse Lung Lu06 856genes Array MG U74Av2 GeneSigDB 1.632E-5 9.591E-4 7.302E-3 1.854E-2 4 449
20 M5825 Angiogenic markers down-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.699E-5 9.591E-4 7.302E-3 1.930E-2 3 138
21 19101988-TableS2 Human Breast Habermann09 18genes GeneSigDB 1.824E-5 9.591E-4 7.302E-3 2.072E-2 2 17
22 15489886-TableS1b Human Sarcoma Mason04 549genes GeneSigDB 1.857E-5 9.591E-4 7.302E-3 2.110E-2 4 464
23 18356575-Table1b Human MesenchymalStemCells Rider08 21genes GeneSigDB 2.051E-5 1.013E-3 7.713E-3 2.330E-2 2 18
24 17023518-Table1 Mouse Lung not cancer Chen06 23genes GeneSigDB 2.546E-5 1.205E-3 9.176E-3 2.893E-2 2 20
25 M15535 Genes up-regulated in UB27 cells (osteosarcoma) at 12 hr after inducing the expression of a mutated form of WT1 [GeneID=7490]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.744E-5 1.229E-3 9.359E-3 3.117E-2 3 162
26 16546165-table5 Mouse StemCell Williams06 23genes GeneSigDB 2.814E-5 1.229E-3 9.359E-3 3.196E-2 2 21
27 19808870-ST3 Human Breast Speers09 24genes GeneSigDB 3.095E-5 1.302E-3 9.912E-3 3.515E-2 2 22
28 M14573 Set 'NOS targets': genes upregulated and identified by ChIP on chip as targets of the transcription factors NANOG , OCT4, and Sox2 [GeneID=79923;5460;6657] (NOS) in human embryonic stem cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.696E-5 1.500E-3 1.142E-2 4.199E-2 3 179
29 M9946 Up-regulated genes of putative pathways stimulated in tumor endothelial cells by papillary serous ovarian epithelial tumor cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.016E-5 1.573E-3 1.198E-2 4.563E-2 2 25
30 M9988 Genes up-regulated in CD8 T cells: control versus primary acute viral infection. MSigDB C7: Immunologic Signatures (v6.0) 4.211E-5 1.594E-3 1.214E-2 4.783E-2 3 187
31 M8843 Genes up-regulated in multipotent progenitors versus pro-B cells. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 1.885E-3 1.435E-2
5.843E-2
 3 200
32 18593982-UpregulatedGeneList Human Breast Nam08 30genes UpregulatedGeneList GeneSigDB 5.818E-5 2.018E-3 1.536E-2
6.609E-2
 2 30
33 M17026 Genes up-regulated in three-dimentional (3D) cultures of preinvasive (S3-C) vs invasive (T4-2) breast cancer cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.947E-5 2.018E-3 1.536E-2
6.756E-2
 3 210
34 17823238-TableS4a Mouse EmbryonicStemCell Soh07 224genes A GeneSigDB 6.117E-5 2.018E-3 1.536E-2
6.949E-2
 3 212
35 M1291 Candidate mammary tumorigenesis genes from the common insertion sites (CIS) of MMTV virus that induced breast tumors in mice. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.218E-5 2.018E-3 1.536E-2
7.064E-2
 2 31
36 17823238-TableS4b Human EmbryonicStemCell Soh07 224genes B GeneSigDB 6.829E-5 2.155E-3 1.641E-2
7.758E-2
 3 220
37 12970448-Table1a Human Viral Radhakrishnan03 48genes GeneSigDB 9.893E-5 3.037E-3 2.312E-2
1.124E-1
 2 39
38 M2255 Genes commonly up-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.108E-4 3.313E-3 2.522E-2
1.259E-1
 3 259
39 M5547 Age up-regulated genes in the human frontal cortex. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.147E-4 3.340E-3 2.542E-2
1.302E-1
 3 262
40 M5312 Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by activated KRAS [GeneID=3845] vs those reverted to normal cells upon over-expression of a dominant negative form of CDC25 [GeneID=5923]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.698E-4 4.822E-3 3.671E-2
1.929E-1
 2 51
41 20460173-ImmPortCytokineReceptors Human Immune Kong10 308genes ImmPort CytokineReceptors GeneSigDB 1.762E-4 4.882E-3 3.717E-2
2.002E-1
 3 303
42 17174972-TableS1 Human Zola07 426genes CellDifferentiationMarkers GeneSigDB 2.583E-4 6.986E-3
5.318E-2
2.934E-1
 3 345
43 19252174-Table3 Human Leukemia Hernandez09 66genes GeneSigDB 2.762E-4 7.298E-3
5.556E-2
3.138E-1
 2 65
44 20521089-SuppTable1a Human Breast Blick10 69genes EMT up GeneSigDB 2.935E-4 7.578E-3
5.769E-2
3.334E-1
 2 67
45 12471243-TableS2 Human Manning02 624genes ProteinKinases GeneSigDB 3.122E-4 7.882E-3
6.000E-2
3.547E-1
 3 368
46 19204204-SupplementaryTable2 Human Breast Parker09 412genes IntrinsicGenes Perou2000 GeneSigDB 3.352E-4 8.277E-3
6.301E-2
3.807E-1
 3 377
47 19799973-Table1 Human Leukemia Visser09 75genes GeneSigDB 3.678E-4 8.890E-3
6.768E-2
4.178E-1
 2 75
48 19074870-SuppTable4a Human StemCell Harris08 490genes GeneSigDB 3.929E-4 9.298E-3
7.079E-2
4.463E-1
 3 398
49 M15981 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.927E-4 1.124E-2
8.555E-2
5.597E-1
 3 430
50 M2761 Top 100 probe sets contrubuting to the positive side of the 2nd principal component; associated with adipocytic differentiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.946E-4 1.124E-2
8.555E-2
5.619E-1
 2 87
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 9 input genes in category / 1216 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MatrixFB-A PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MatrixFB-A PND01-03 Top 200 Genes 1.608E-9 1.955E-6 1.502E-5 1.955E-6 6 362
2 Lung Development Lungmap - Mouse FluidigmC1 Fibroblast Overall Top 500 Genes Lung Development Lungmap - Mouse FluidigmC1 Fibroblast Overall Top 500 Genes 7.108E-9 4.322E-6 3.319E-5 8.643E-6 6 464
3 Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-B Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-B Lungmap CCHMC 2.298E-8 8.561E-6 6.576E-5 2.794E-5 5 250
4 Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-E Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-E Lungmap CCHMC 2.905E-8 8.561E-6 6.576E-5 3.532E-5 5 262
5 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-2 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-2 Top 200 Genes 4.269E-8 8.561E-6 6.576E-5 5.192E-5 5 283
6 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-2 PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-2 PND01-03 Top 200 Genes 4.269E-8 8.561E-6 6.576E-5 5.192E-5 5 283
7 Lungmap Mouse Lung PND1 MatrixFB Subtype All subclasses Lungmap Mouse Lung PND1 MatrixFB Subtype All subclasses Lungmap CCHMC 4.928E-8 8.561E-6 6.576E-5 5.993E-5 4 99
8 BrainMap BrainAtlas - Mouse McCarroll Astrocyte.astrocytes.Rorb Astrocyte.astrocytes.Rorb Subtype subAstrocyte.Rorb.subGroup1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Astrocyte.astrocytes.Rorb Astrocyte.astrocytes.Rorb Subtype subAstrocyte.Rorb.subGroup1 Top 200 Genes BrainMap 6.203E-8 9.428E-6 7.242E-5 7.543E-5 5 305
9 BrainMap BrainAtlas - Mouse McCarroll Astrocyte.astrocytes.Rorb Astrocyte.astrocytes.Rorb Top 200 BrainMap BrainAtlas - Mouse McCarroll Astrocyte.astrocytes.Rorb Astrocyte.astrocytes.Rorb Top 200 BrainMap 1.249E-7 1.687E-5 1.296E-4 1.518E-4 5 351
10 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MatrixFB-A Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MatrixFB-A Top 200 Genes 1.558E-7 1.895E-5 1.456E-4 1.895E-4 5 367
11 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin/keratinocyte stem cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin/keratinocyte stem cell Tabula Muris Consortium 7.360E-7 8.136E-5 6.249E-4 8.950E-4 4 194
12 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MatrixFB-A Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MatrixFB-A Top 200 Genes 1.216E-6 1.202E-4 9.231E-4 1.478E-3 4 220
13 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MatrixFB-A E18.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MatrixFB-A E18.5 Top 200 Genes 1.306E-6 1.202E-4 9.231E-4 1.589E-3 4 224
14 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MatrixFB-A PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MatrixFB-A PND01-03 Top 200 Genes 1.452E-6 1.202E-4 9.231E-4 1.765E-3 4 230
15 Lungmap Mouse Lung PND1 MyoFB Subtype MyoFB-E Lungmap Mouse Lung PND1 MyoFB Subtype MyoFB-E Lungmap CCHMC 1.581E-6 1.202E-4 9.231E-4 1.923E-3 4 235
16 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-3 PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-3 PND01-03 Top 200 Genes 1.581E-6 1.202E-4 9.231E-4 1.923E-3 4 235
17 Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-C Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-C Lungmap CCHMC 2.747E-6 1.911E-4 1.468E-3 3.340E-3 4 270
18 Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-A Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-A Lungmap CCHMC 2.829E-6 1.911E-4 1.468E-3 3.440E-3 4 272
19 Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-F Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-F Lungmap CCHMC 3.041E-6 1.946E-4 1.495E-3 3.698E-3 4 277
20 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal D Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal D Top 200 Genes 4.752E-6 2.752E-4 2.114E-3 5.779E-3 4 310
21 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes 4.752E-6 2.752E-4 2.114E-3 5.779E-3 4 310
22 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal B PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal B PND01-03 Top 200 Genes 5.000E-6 2.764E-4 2.123E-3 6.080E-3 4 314
23 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal B PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal B PND01-03 Top 200 Genes 6.160E-6 3.159E-4 2.426E-3 7.491E-3 4 331
24 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal B E18.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal B E18.5 Top 200 Genes 6.234E-6 3.159E-4 2.426E-3 7.581E-3 4 332
25 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MatrixFB-A E18.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MatrixFB-A E18.5 Top 200 Genes 7.857E-6 3.445E-4 2.646E-3 9.554E-3 4 352
26 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype Early Fibroblastic Progenitor E16.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype Early Fibroblastic Progenitor E16.5 Top 200 Genes 8.125E-6 3.445E-4 2.646E-3 9.880E-3 4 355
27 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype Early Fibroblastic Progenitor Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype Early Fibroblastic Progenitor Top 200 Genes 8.125E-6 3.445E-4 2.646E-3 9.880E-3 4 355
28 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal B E18.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal B E18.5 Top 200 Genes 8.399E-6 3.445E-4 2.646E-3 1.021E-2 4 358
29 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-1 E18.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-1 E18.5 Top 200 Genes 8.969E-6 3.445E-4 2.646E-3 1.091E-2 4 364
30 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-1 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-1 Top 200 Genes 8.969E-6 3.445E-4 2.646E-3 1.091E-2 4 364
31 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes 9.067E-6 3.445E-4 2.646E-3 1.103E-2 4 365
32 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D Top 200 Genes 9.067E-6 3.445E-4 2.646E-3 1.103E-2 4 365
33 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-3 PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-3 PND01-03 Top 200 Genes 9.466E-6 3.488E-4 2.679E-3 1.151E-2 4 369
34 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal C PND07-28 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal C PND07-28 Top 200 Genes 1.009E-5 3.505E-4 2.692E-3 1.227E-2 4 375
35 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal C Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal C Top 200 Genes 1.009E-5 3.505E-4 2.692E-3 1.227E-2 4 375
36 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Overall Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Overall Top 200 Genes 4.392E-5 1.468E-3 1.127E-2
5.341E-2
 3 179
37 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Spon1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Spon1 BrainMap 4.466E-5 1.468E-3 1.127E-2
5.430E-2
 3 180
38 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Overall Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Overall Top 200 Genes 5.329E-5 1.705E-3 1.310E-2
6.480E-2
 3 191
39 Facebase RNAseq e10.5 Medial Nasal Eminence 2500 K5 FacebaseRNAseq e10.5 Medial Nasal Eminence top-relative-expression-ranked 2500 k-means-cluster#5 FaceBase_RNAseq 6.202E-5 1.934E-3 1.485E-2
7.542E-2
 3 201
40 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-3 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-3 Top 200 Genes 7.065E-5 2.084E-3 1.601E-2
8.591E-2
 3 210
41 Facebase RNAseq e8.5 Paraxial Mesoderm 2500 K5 FacebaseRNAseq e8.5 Paraxial Mesoderm top-relative-expression-ranked 2500 k-means-cluster#5 FaceBase_RNAseq 7.065E-5 2.084E-3 1.601E-2
8.591E-2
 3 210
42 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-1 E18.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-1 E18.5 Top 200 Genes 7.369E-5 2.084E-3 1.601E-2
8.960E-2
 3 213
43 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-1 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-1 Top 200 Genes 7.369E-5 2.084E-3 1.601E-2
8.960E-2
 3 213
44 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-3 PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-3 PND07-28 Top 200 Genes 7.787E-5 2.109E-3 1.620E-2
9.469E-2
 3 217
45 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 2 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 2 Top 200 Genes 8.111E-5 2.109E-3 1.620E-2
9.863E-2
 3 220
46 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 2 E16.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 2 E16.5 Top 200 Genes 8.111E-5 2.109E-3 1.620E-2
9.863E-2
 3 220
47 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Intermediate Fibroblast E16.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Intermediate Fibroblast E16.5 Top 200 Genes 8.444E-5 2.109E-3 1.620E-2
1.027E-1
 3 223
48 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Intermediate Fibroblast Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Intermediate Fibroblast Top 200 Genes 8.444E-5 2.109E-3 1.620E-2
1.027E-1
 3 223
49 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 1 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 1 Top 200 Genes 8.670E-5 2.109E-3 1.620E-2
1.054E-1
 3 225
50 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 1 E16.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 1 E16.5 Top 200 Genes 8.670E-5 2.109E-3 1.620E-2
1.054E-1
 3 225
Show 45 more annotations

15: Computational [Display Chart] 8 input genes in category / 98 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13974 MODULE 259 RTK signaling. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.965E-6 3.114E-4 1.609E-3 4.866E-4 3 46
2 M19421 MODULE 85 Genes in the cancer module 85. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.799E-6 3.114E-4 1.609E-3 6.663E-4 3 51
3 M17161 MODULE 199 Genes in the cancer module 199. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.531E-6 3.114E-4 1.609E-3 9.341E-4 3 57
4 M688 MODULE 27 Genes in the cancer module 27. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.622E-5 1.992E-3 1.029E-2 9.429E-3 4 355
5 M18929 MODULE 12 Spinal cord (neuro-development) genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.016E-4 1.992E-3 1.029E-2 9.958E-3 4 360
6 M5770 MODULE 63 Porins / transporters. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.745E-4 7.408E-3 3.828E-2 4.650E-2 3 211
7 M2175 MODULE 129 Signaling. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.292E-4 7.408E-3 3.828E-2
5.186E-2
 3 219
8 M4082 MODULE 234 Bone remodeling. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.792E-4 9.545E-3 4.932E-2
7.636E-2
 2 54
9 M7888 MODULE 433 Cytokines and GFs. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.937E-4 1.082E-2
5.591E-2
9.738E-2
 2 61
10 M13472 MODULE 99 Genes in the cancer module 99. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.205E-3 2.160E-2
1.116E-1
2.160E-1
 3 358
11 M9982 MODULE 2 DRG (dorsal root ganglia) genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.695E-3 2.401E-2
1.241E-1
2.641E-1
 3 384
12 M15336 MODULE 6 Trachea genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.387E-3 2.766E-2
1.429E-1
3.319E-1
 3 416
13 M10190 MODULE 52 Cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.796E-3 2.862E-2
1.479E-1
3.720E-1
 3 433
Show 8 more annotations

16: MicroRNA [Display Chart] 9 input genes in category / 435 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TAATAAT,MIR-126:MSigDB TAATAAT,MIR-126:MSigDB MSigDB 1.868E-6 8.125E-4 5.406E-3 8.125E-4 3 205
2 hsa-miR-323b-5p:mirSVR highEffct hsa-miR-323b-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.027E-5 4.409E-3 2.934E-2 8.818E-3 3 455
3 hsa-miR-1224-5p:TargetScan hsa-miR-1224-5p TargetScan 1.568E-4 1.547E-2
1.030E-1
6.821E-2
 2 152
4 hsa-miR-484:PITA hsa-miR-484:PITA TOP PITA 1.609E-4 1.547E-2
1.030E-1
7.001E-2
 2 154
5 hsa-miR-640:PITA hsa-miR-640:PITA TOP PITA 2.030E-4 1.547E-2
1.030E-1
8.831E-2
 2 173
6 hsa-miR-659:PITA hsa-miR-659:PITA TOP PITA 4.192E-4 1.547E-2
1.030E-1
1.824E-1
 2 249
7 hsa-miR-455-3p:PITA hsa-miR-455-3p:PITA TOP PITA 4.430E-4 1.547E-2
1.030E-1
1.927E-1
 2 256
8 hsa-miR-1303:PITA hsa-miR-1303:PITA TOP PITA 4.534E-4 1.547E-2
1.030E-1
1.972E-1
 2 259
9 TATTATA,MIR-374:MSigDB TATTATA,MIR-374:MSigDB MSigDB 4.780E-4 1.547E-2
1.030E-1
2.079E-1
 2 266
10 hsa-miR-298:PITA hsa-miR-298:PITA TOP PITA 4.888E-4 1.547E-2
1.030E-1
2.126E-1
 2 269
11 hsa-miR-671-3p:mirSVR lowEffct hsa-miR-671-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 4.924E-4 1.547E-2
1.030E-1
2.142E-1
 2 270
12 hsa-miR-21-5p:TargetScan hsa-miR-21-5p TargetScan 5.406E-4 1.547E-2
1.030E-1
2.352E-1
 2 283
13 hsa-miR-590-5p:TargetScan hsa-miR-590-5p TargetScan 5.444E-4 1.547E-2
1.030E-1
2.368E-1
 2 284
14 CAGTGTT,MIR-141:MSigDB CAGTGTT,MIR-141:MSigDB MSigDB 5.714E-4 1.547E-2
1.030E-1
2.485E-1
 2 291
15 CAGTGTT,MIR-200A:MSigDB CAGTGTT,MIR-200A:MSigDB MSigDB 5.714E-4 1.547E-2
1.030E-1
2.485E-1
 2 291
16 hsa-miR-155:PITA hsa-miR-155:PITA TOP PITA 6.231E-4 1.547E-2
1.030E-1
2.711E-1
 2 304
17 TGCTTTG,MIR-330:MSigDB TGCTTTG,MIR-330:MSigDB MSigDB 6.644E-4 1.547E-2
1.030E-1
2.890E-1
 2 314
18 hsa-miR-515-5p:PITA hsa-miR-515-5p:PITA TOP PITA 6.771E-4 1.547E-2
1.030E-1
2.945E-1
 2 317
19 hsa-miR-139-5p:PITA hsa-miR-139-5p:PITA TOP PITA 6.856E-4 1.547E-2
1.030E-1
2.982E-1
 2 319
20 hsa-miR-500:PITA hsa-miR-500:PITA TOP PITA 7.114E-4 1.547E-2
1.030E-1
3.095E-1
 2 325
21 hsa-miR-410:PITA hsa-miR-410:PITA TOP PITA 8.904E-4 1.658E-2
1.103E-1
3.873E-1
 2 364
22 hsa-miR-1263:mirSVR highEffct hsa-miR-1263:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.148E-4 1.658E-2
1.103E-1
3.979E-1
 2 369
23 hsa-miR-330-5p:TargetScan hsa-miR-330-5p TargetScan 9.148E-4 1.658E-2
1.103E-1
3.979E-1
 2 369
24 hsa-miR-326:TargetScan hsa-miR-326 TargetScan 9.148E-4 1.658E-2
1.103E-1
3.979E-1
 2 369
25 ACCGAGC,MIR-423:MSigDB ACCGAGC,MIR-423:MSigDB MSigDB 9.963E-4 1.686E-2
1.122E-1
4.334E-1
 1 8
26 hsa-miR-103:PITA hsa-miR-103:PITA TOP PITA 1.047E-3 1.686E-2
1.122E-1
4.553E-1
 2 395
27 hsa-miR-107:PITA hsa-miR-107:PITA TOP PITA 1.047E-3 1.686E-2
1.122E-1
4.553E-1
 2 395
28 hsa-miR-133a-3p.1:TargetScan hsa-miR-133a-3p.1 TargetScan 1.148E-3 1.784E-2
1.187E-1
4.996E-1
 2 414
29 hsa-miR-410-3p:TargetScan hsa-miR-410-3p TargetScan 1.243E-3 1.824E-2
1.214E-1
5.409E-1
 2 431
30 hsa-miR-494-3p:TargetScan hsa-miR-494-3p TargetScan 1.330E-3 1.824E-2
1.214E-1
5.787E-1
 2 446
31 hsa-miR-486-5p:mirSVR highEffct hsa-miR-486-5p:mirSVR conserved highEffect-0.5 MicroRNA.org 1.336E-3 1.824E-2
1.214E-1
5.813E-1
 2 447
32 hsa-miR-186-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.378E-3 1.824E-2
1.214E-1
5.994E-1
 2 454
33 hsa-miR-365*:mirSVR highEffct hsa-miR-365*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.384E-3 1.824E-2
1.214E-1
6.020E-1
 2 455
34 hsa-miR-377-3p:TargetScan hsa-miR-377-3p TargetScan 1.494E-3 1.860E-2
1.238E-1
6.498E-1
 2 473
35 hsa-miR-4308:mirSVR highEffct hsa-miR-4308:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.531E-3 1.860E-2
1.238E-1
6.662E-1
 2 479
36 hsa-miR-133a-3p.2:TargetScan hsa-miR-133a-3p.2 TargetScan 1.582E-3 1.860E-2
1.238E-1
6.883E-1
 2 487
37 hsa-miR-133b:TargetScan hsa-miR-133b TargetScan 1.582E-3 1.860E-2
1.238E-1
6.883E-1
 2 487
38 TACGGGT,MIR-100:MSigDB TACGGGT,MIR-100:MSigDB MSigDB 2.862E-3 3.112E-2
2.071E-1
1.000E0
 1 23
39 TACGGGT,MIR-99B:MSigDB TACGGGT,MIR-99B:MSigDB MSigDB 2.862E-3 3.112E-2
2.071E-1
1.000E0
 1 23
40 TACGGGT,MIR-99A:MSigDB TACGGGT,MIR-99A:MSigDB MSigDB 2.862E-3 3.112E-2
2.071E-1
1.000E0
 1 23
41 hsa-miR-423-3p:PITA hsa-miR-423-3p:PITA TOP PITA 2.986E-3 3.168E-2
2.108E-1
1.000E0
 1 24
42 hsa-miR-100:PITA hsa-miR-100:PITA TOP PITA 4.104E-3 4.057E-2
2.700E-1
1.000E0
 1 33
43 hsa-miR-99b:PITA hsa-miR-99b:PITA TOP PITA 4.104E-3 4.057E-2
2.700E-1
1.000E0
 1 33
44 hsa-miR-99a:PITA hsa-miR-99a:PITA TOP PITA 4.104E-3 4.057E-2
2.700E-1
1.000E0
 1 33
45 GGCAGAC,MIR-346:MSigDB GGCAGAC,MIR-346:MSigDB MSigDB 4.849E-3 4.568E-2
3.039E-1
1.000E0
 1 39
46 hsa-miR-6826-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.097E-3 4.568E-2
3.039E-1
1.000E0
 1 41
47 hsa-miR-6069:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 4.568E-2
3.039E-1
1.000E0
 1 42
48 hsa-miR-99a-5p:TargetScan hsa-miR-99a-5p TargetScan 5.345E-3 4.568E-2
3.039E-1
1.000E0
 1 43
49 hsa-miR-100-5p:TargetScan hsa-miR-100-5p TargetScan 5.345E-3 4.568E-2
3.039E-1
1.000E0
 1 43
50 hsa-miR-99b-5p:TargetScan hsa-miR-99b-5p TargetScan 5.345E-3 4.568E-2
3.039E-1
1.000E0
 1 43
Show 45 more annotations

17: Drug [Display Chart] 9 input genes in category / 4771 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:D006497 Heparitin Sulfate CTD 8.724E-20 4.162E-16 3.766E-15 4.162E-16 7 29
2 CID000001401 PD173074 Stitch 3.881E-17 9.258E-14 8.376E-13 1.852E-13 7 65
3 ctd:C105686 SU 5402 CTD 1.229E-14 1.954E-11 1.768E-10 5.862E-11 6 55
4 CID000206042 SU6668 Stitch 5.548E-14 6.617E-11 5.987E-10 2.647E-10 6 70
5 CID000005307 A19413 Stitch 2.626E-12 2.506E-9 2.267E-8 1.253E-8 6 131
6 ctd:D006493 Heparin CTD 3.938E-12 3.132E-9 2.833E-8 1.879E-8 6 140
7 CID000032756 dermatan sulfate Stitch 6.116E-11 4.168E-8 3.771E-7 2.918E-7 6 220
8 CID000133885 Bch 325 Stitch 1.177E-10 7.018E-8 6.349E-7 5.614E-7 4 24
9 ctd:C568950 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea CTD 1.692E-10 8.968E-8 8.114E-7 8.071E-7 3 4
10 ctd:D009844 Oligosaccharides CTD 2.266E-10 1.081E-7 9.781E-7 1.081E-6 4 28
11 CID000492400 NVP & EFV Stitch 4.756E-10 2.038E-7 1.844E-6 2.269E-6 5 121
12 CID000159247 sevelamer hydrochloride Stitch 5.127E-10 2.038E-7 1.844E-6 2.446E-6 4 34
13 DB00039 Palifermin Drug Bank 8.455E-10 3.103E-7 2.807E-6 4.034E-6 3 6
14 CID000006035 bromodeoxyuridine Stitch 1.541E-9 5.251E-7 4.751E-6 7.352E-6 6 376
15 ctd:D014284 Triiodothyronine CTD 6.901E-9 2.195E-6 1.986E-5 3.292E-5 6 483
16 CID000003496 glyphosate Stitch 8.619E-9 2.570E-6 2.325E-5 4.112E-5 5 215
17 CID005311382 PD 166285 Stitch 9.290E-9 2.607E-6 2.359E-5 4.432E-5 3 12
18 ctd:C007350 nitrofen CTD 1.434E-8 3.665E-6 3.316E-5 6.844E-5 5 238
19 ctd:C115711 PD 173074 CTD 1.536E-8 3.665E-6 3.316E-5 7.330E-5 3 14
20 ctd:D019812 Heparan Sulfate Proteoglycans CTD 1.536E-8 3.665E-6 3.316E-5 7.330E-5 3 14
21 CID000037720 pentosan polysulfate Stitch 1.648E-8 3.744E-6 3.387E-5 7.862E-5 4 79
22 CID000000946 nitrite ion Stitch 1.948E-8 4.224E-6 3.822E-5 9.293E-5 5 253
23 CID000005277 NSC233046 Stitch 2.114E-8 4.386E-6 3.968E-5 1.009E-4 4 84
24 ctd:C561052 5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one CTD 2.363E-8 4.697E-6 4.250E-5 1.127E-4 3 16
25 ctd:C058705 diethyl malate CTD 2.554E-8 4.873E-6 4.409E-5 1.218E-4 4 88
26 ctd:D003871 Dermatan Sulfate CTD 2.868E-8 5.169E-6 4.677E-5 1.369E-4 3 17
27 CID003036909 CTDs Stitch 2.925E-8 5.169E-6 4.677E-5 1.396E-4 4 91
28 CID000018845 iduronic acid Stitch 3.633E-8 6.190E-6 5.600E-5 1.733E-4 4 96
29 CID009961424 R1C Stitch 4.806E-8 7.679E-6 6.948E-5 2.293E-4 3 20
30 CID000019654 chlorate Stitch 4.829E-8 7.679E-6 6.948E-5 2.304E-4 4 103
31 CID000002142 amikacin sulphate Stitch 5.219E-8 8.032E-6 7.267E-5 2.490E-4 4 105
32 CID000122191 DMRIE Stitch 7.462E-8 1.113E-5 1.007E-4 3.560E-4 3 23
33 ctd:C010452 estradiol-17 beta-benzoate CTD 8.526E-8 1.233E-5 1.115E-4 4.068E-4 3 24
34 DB02058 SU4984 Drug Bank 1.380E-7 1.937E-5 1.752E-4 6.585E-4 2 2
35 CID000000149 MeSAdo Stitch 1.525E-7 2.041E-5 1.846E-4 7.274E-4 4 137
36 CID000002833 colchine Stitch 1.540E-7 2.041E-5 1.846E-4 7.347E-4 5 383
37 CID009930048 vernakalant Stitch 1.708E-7 2.203E-5 1.993E-4 8.150E-4 3 30
38 CID000005291 imatinib Stitch 2.736E-7 3.281E-5 2.969E-4 1.305E-3 5 430
39 CID000129949 nitrobenzyl-DOTA Stitch 2.751E-7 3.281E-5 2.969E-4 1.313E-3 3 35
40 CID000105059 TFE-Cys Stitch 2.751E-7 3.281E-5 2.969E-4 1.313E-3 3 35
41 ctd:C024552 estrone benzoate CTD 4.140E-7 4.713E-5 4.264E-4 1.975E-3 2 3
42 CID000978607 BDP X Stitch 4.149E-7 4.713E-5 4.264E-4 1.979E-3 3 40
43 6627 UP Methoxamine hydrochloride [61-16-5]; Up 200; 16.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 6.672E-7 7.382E-5 6.679E-4 3.183E-3 4 198
44 5728 UP Tetrahydroalstonine [6474-90-4]; Up 200; 11.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 6.808E-7 7.382E-5 6.679E-4 3.248E-3 4 199
45 CID000010112 calcium carbonate Stitch 7.665E-7 8.127E-5 7.353E-4 3.657E-3 4 205
46 CID000005360 suramin Stitch 8.123E-7 8.425E-5 7.623E-4 3.875E-3 4 208
47 CID000516902 sodium chlorate Stitch 8.726E-7 8.858E-5 8.014E-4 4.163E-3 3 51
48 CID000446388 Su-M Stitch 9.258E-7 9.203E-5 8.326E-4 4.417E-3 3 52
49 CID000440118 C03789 Stitch 1.291E-6 1.242E-4 1.123E-3 6.160E-3 3 58
50 CID006540261 EI-N Stitch 1.344E-6 1.242E-4 1.123E-3 6.413E-3 4 236
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 1197 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0001193 Apert syndrome DisGeNET Curated 2.167E-11 9.453E-9 7.246E-8 2.594E-8 4 12
2 C1856266 Coronal craniosynostosis DisGeNET Curated 5.972E-11 9.453E-9 7.246E-8 7.148E-8 4 15
3 C0948060 Iridocele DisGeNET Curated 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
4 C1400252 Parotid gland hypoplasia DisGeNET Curated 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
5 C4024215 Aplasia of the parotid gland DisGeNET Curated 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
6 C4020779 Absence of the parotid gland DisGeNET Curated 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
7 C4021418 Absent proximal phalanx of thumb DisGeNET Curated 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
8 C4021723 Short middle phalanx of toe DisGeNET Curated 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
9 C4021627 Bilateral triphalangeal thumbs DisGeNET Curated 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
10 C4021564 Hypoplasia of the lacrimal puncta DisGeNET Curated 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
11 C1863200 Hypoplastic lacrimal gland DisGeNET Curated 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
12 C4024822 Lacrimal gland aplasia DisGeNET Curated 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
13 C1968574 Hypoplastic lacrimal duct DisGeNET Curated 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
14 cv:C0265269 Levy-Hollister syndrome Clinical Variations 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
15 OMIN:149730 LACRIMOAURICULODENTODIGITAL SYNDROME; LADD OMIM 1.185E-10 9.453E-9 7.246E-8 1.418E-7 3 3
16 C1858569 Absence of Stensen duct DisGeNET Curated 4.737E-10 2.363E-8 1.811E-7 5.670E-7 3 4
17 C0344509 Agenesis of punctum lacrimale DisGeNET Curated 4.737E-10 2.363E-8 1.811E-7 5.670E-7 3 4
18 C1867060 Lacrimal Puncta, Absence of DisGeNET Curated 4.737E-10 2.363E-8 1.811E-7 5.670E-7 3 4
19 C0010930 Dacryocystitis DisGeNET Curated 4.737E-10 2.363E-8 1.811E-7 5.670E-7 3 4
20 C4024345 Radial deviation of the 3rd finger DisGeNET Curated 4.737E-10 2.363E-8 1.811E-7 5.670E-7 3 4
21 C0265269 Lacrimoauriculodentodigital syndrome DisGeNET Curated 4.737E-10 2.363E-8 1.811E-7 5.670E-7 3 4
22 C4280674 Agenesis of parotid duct DisGeNET Curated 4.737E-10 2.363E-8 1.811E-7 5.670E-7 3 4
23 C1394030 Coronal hypospadias DisGeNET Curated 4.737E-10 2.363E-8 1.811E-7 5.670E-7 3 4
24 C1846474 Thenar hypoplasia DisGeNET Curated 4.737E-10 2.363E-8 1.811E-7 5.670E-7 3 4
25 C0008924 Cleft Lip DisGeNET Curated 8.122E-10 3.889E-8 2.981E-7 9.721E-7 5 96
26 C1867131 Broad hallux DisGeNET Curated 1.035E-9 4.767E-8 3.654E-7 1.239E-6 4 29
27 C4020787 Subcoronal hypospadias DisGeNET Curated 1.184E-9 5.249E-8 4.023E-7 1.417E-6 3 5
28 C4082168 Partial duplication of thumb phalanx DisGeNET Curated 2.367E-9 8.334E-8 6.388E-7 2.834E-6 3 6
29 C4020759 Pointed incisor DisGeNET Curated 2.367E-9 8.334E-8 6.388E-7 2.834E-6 3 6
30 C4280341 Pointed front tooth DisGeNET Curated 2.367E-9 8.334E-8 6.388E-7 2.834E-6 3 6
31 C0220658 Pfeiffer Syndrome DisGeNET Curated 2.367E-9 8.334E-8 6.388E-7 2.834E-6 3 6
32 C4280564 Cloverleaf cranium shape DisGeNET Curated 2.367E-9 8.334E-8 6.388E-7 2.834E-6 3 6
33 C1856136 Peg-shaped incisors DisGeNET Curated 2.367E-9 8.334E-8 6.388E-7 2.834E-6 3 6
34 C4280342 Peg shaped front tooth DisGeNET Curated 2.367E-9 8.334E-8 6.388E-7 2.834E-6 3 6
35 C0235942 Skull malformation DisGeNET Curated 3.211E-9 1.098E-7 8.418E-7 3.844E-6 4 38
36 C0432283 Osteoglophonic dwarfism DisGeNET Curated 4.141E-9 1.340E-7 1.027E-6 4.957E-6 3 7
37 C1860050 Cloverleaf skull DisGeNET Curated 4.141E-9 1.340E-7 1.027E-6 4.957E-6 3 7
38 C0542519 Congenital absence of kidney DisGeNET Curated 4.864E-9 1.532E-7 1.174E-6 5.822E-6 4 42
39 C0432055 Simple syndactyly of fingers - first web DisGeNET Curated 9.934E-9 2.831E-7 2.170E-6 1.189E-5 3 9
40 C0022906 Lacrimal Duct Obstruction DisGeNET Curated 9.934E-9 2.831E-7 2.170E-6 1.189E-5 3 9
41 C1858036 Periorbital fullness DisGeNET Curated 9.934E-9 2.831E-7 2.170E-6 1.189E-5 3 9
42 C1281931 Obstruction of nasolacrimal duct DisGeNET Curated 9.934E-9 2.831E-7 2.170E-6 1.189E-5 3 9
43 C1849538 Delayed eruption of primary teeth DisGeNET Curated 1.419E-8 3.860E-7 2.958E-6 1.698E-5 3 10
44 C0344505 Alacrima DisGeNET Curated 1.419E-8 3.860E-7 2.958E-6 1.698E-5 3 10
45 C0151846 Periosteal Disorder DisGeNET BeFree 1.950E-8 5.188E-7 3.976E-6 2.334E-5 3 11
46 C1849089 Broad forehead DisGeNET Curated 2.110E-8 5.490E-7 4.208E-6 2.525E-5 4 60
47 C0423113 Telecanthus DisGeNET Curated 2.412E-8 6.144E-7 4.709E-6 2.888E-5 4 62
48 C4020888 Epithelial corneal erosions DisGeNET Curated 2.600E-8 6.223E-7 4.770E-6 3.112E-5 3 12
49 C0003803 Arnold Chiari Malformation DisGeNET Curated 2.600E-8 6.223E-7 4.770E-6 3.112E-5 3 12
50 C0039093 Congenital abnormal Synostosis DisGeNET BeFree 2.600E-8 6.223E-7 4.770E-6 3.112E-5 3 12
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