Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc21_34, positive side

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1: GO: Molecular Function [Display Chart] 34 input genes in category / 113 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004252 serine-type endopeptidase activity 3.443E-12 3.890E-10 2.065E-9 3.890E-10 10 215
2 GO:0008236 serine-type peptidase activity 1.115E-11 4.488E-10 2.382E-9 1.260E-9 10 242
3 GO:0017171 serine hydrolase activity 1.260E-11 4.488E-10 2.382E-9 1.423E-9 10 245
4 GO:0004866 endopeptidase inhibitor activity 1.589E-11 4.488E-10 2.382E-9 1.795E-9 9 171
5 GO:0061135 endopeptidase regulator activity 2.167E-11 4.747E-10 2.520E-9 2.449E-9 9 177
6 GO:0030414 peptidase inhibitor activity 2.520E-11 4.747E-10 2.520E-9 2.848E-9 9 180
7 GO:0061134 peptidase regulator activity 1.644E-10 2.654E-9 1.409E-8 1.858E-8 9 222
8 GO:0004175 endopeptidase activity 2.903E-10 4.100E-9 2.177E-8 3.280E-8 11 457
9 GO:0004867 serine-type endopeptidase inhibitor activity 3.667E-10 4.604E-9 2.444E-8 4.144E-8 7 96
10 GO:0004857 enzyme inhibitor activity 1.279E-9 1.446E-8 7.676E-8 1.446E-7 10 393
11 GO:0002020 protease binding 1.965E-6 2.018E-5 1.071E-4 2.220E-4 5 115
12 GO:0008147 structural constituent of bone 3.222E-6 3.034E-5 1.611E-4 3.641E-4 2 2
13 GO:0008201 heparin binding 2.327E-4 2.023E-3 1.074E-2 2.630E-2 4 167
14 GO:0050839 cell adhesion molecule binding 5.351E-4 4.319E-3 2.293E-2
6.047E-2
 4 208
15 GO:0005543 phospholipid binding 6.191E-4 4.586E-3 2.435E-2
6.996E-2
 5 385
16 GO:0005539 glycosaminoglycan binding 6.493E-4 4.586E-3 2.435E-2
7.337E-2
 4 219
17 GO:1901681 sulfur compound binding 1.229E-3 8.170E-3 4.338E-2
1.389E-1
 4 260
18 GO:0070009 serine-type aminopeptidase activity 3.641E-3 2.165E-2
1.150E-1
4.114E-1
 1 2
19 GO:0008488 gamma-glutamyl carboxylase activity 3.641E-3 2.165E-2
1.150E-1
4.114E-1
 1 2
20 GO:0060090 molecular adaptor activity 4.306E-3 2.433E-2
1.292E-1
4.865E-1
 3 181
21 GO:0005507 copper ion binding 5.338E-3 2.681E-2
1.423E-1
6.032E-1
 2 60
22 GO:0030971 receptor tyrosine kinase binding 5.338E-3 2.681E-2
1.423E-1
6.032E-1
 2 60
23 GO:0060230 lipoprotein lipase activator activity 5.456E-3 2.681E-2
1.423E-1
6.166E-1
 1 3
24 GO:1990782 protein tyrosine kinase binding 6.425E-3 3.025E-2
1.606E-1
7.260E-1
 2 66
25 GO:0070053 thrombospondin receptor activity 7.269E-3 3.285E-2
1.744E-1
8.214E-1
 1 4
26 GO:0051087 chaperone binding 9.769E-3 4.185E-2
2.222E-1
1.000E0
 2 82
27 GO:0042562 hormone binding 9.998E-3 4.185E-2
2.222E-1
1.000E0
 2 83
28 GO:0070324 thyroid hormone binding 1.088E-2 4.392E-2
2.332E-1
1.000E0
 1 6
29 GO:0046848 hydroxyapatite binding 1.269E-2 4.943E-2
2.624E-1
1.000E0
 1 7
Show 24 more annotations

2: GO: Biological Process [Display Chart] 34 input genes in category / 1006 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007596 blood coagulation 2.205E-38 1.067E-35 7.991E-35 2.218E-35 26 363
2 GO:0050817 coagulation 3.181E-38 1.067E-35 7.991E-35 3.200E-35 26 368
3 GO:0007599 hemostasis 3.181E-38 1.067E-35 7.991E-35 3.200E-35 26 368
4 GO:0030193 regulation of blood coagulation 2.834E-31 5.701E-29 4.271E-28 2.851E-28 17 92
5 GO:1900046 regulation of hemostasis 2.834E-31 5.701E-29 4.271E-28 2.851E-28 17 92
6 GO:0050818 regulation of coagulation 6.243E-31 1.047E-28 7.842E-28 6.281E-28 17 96
7 GO:1900047 negative regulation of hemostasis 2.517E-28 3.165E-26 2.371E-25 2.532E-25 14 51
8 GO:0030195 negative regulation of blood coagulation 2.517E-28 3.165E-26 2.371E-25 2.532E-25 14 51
9 GO:0061041 regulation of wound healing 3.571E-28 3.991E-26 2.990E-25 3.592E-25 17 136
10 GO:0050819 negative regulation of coagulation 4.671E-28 4.699E-26 3.520E-25 4.699E-25 14 53
11 GO:0072378 blood coagulation, fibrin clot formation 1.441E-27 1.318E-25 9.871E-25 1.449E-24 12 26
12 GO:0061045 negative regulation of wound healing 9.196E-27 7.709E-25 5.775E-24 9.251E-24 14 64
13 GO:0016485 protein processing 7.248E-25 5.609E-23 4.202E-22 7.291E-22 19 338
14 GO:0042730 fibrinolysis 1.569E-24 1.128E-22 8.448E-22 1.579E-21 11 27
15 GO:0051604 protein maturation 3.349E-24 2.246E-22 1.682E-21 3.369E-21 19 366
16 GO:1903035 negative regulation of response to wounding 8.011E-22 5.037E-20 3.773E-19 8.059E-19 15 185
17 GO:0072376 protein activation cascade 5.483E-21 3.244E-19 2.431E-18 5.516E-18 13 112
18 GO:0018214 protein carboxylation 8.330E-21 4.411E-19 3.304E-18 8.380E-18 8 11
19 GO:0017187 peptidyl-glutamic acid carboxylation 8.330E-21 4.411E-19 3.304E-18 8.380E-18 8 11
20 GO:0031639 plasminogen activation 2.050E-20 1.031E-18 7.727E-18 2.063E-17 9 21
21 GO:1903034 regulation of response to wounding 8.675E-19 4.156E-17 3.113E-16 8.727E-16 17 472
22 GO:0032102 negative regulation of response to external stimulus 2.908E-18 1.330E-16 9.961E-16 2.925E-15 15 317
23 GO:0007597 blood coagulation, intrinsic pathway 3.778E-18 1.653E-16 1.238E-15 3.801E-15 8 19
24 GO:0002576 platelet degranulation 3.406E-17 1.428E-15 1.069E-14 3.426E-14 11 107
25 GO:0006465 signal peptide processing 5.366E-17 2.159E-15 1.618E-14 5.399E-14 8 25
26 GO:0030194 positive regulation of blood coagulation 1.536E-16 5.724E-15 4.288E-14 1.546E-13 8 28
27 GO:1900048 positive regulation of hemostasis 1.536E-16 5.724E-15 4.288E-14 1.546E-13 8 28
28 GO:0031638 zymogen activation 2.852E-16 1.001E-14 7.500E-14 2.869E-13 11 129
29 GO:0018200 peptidyl-glutamic acid modification 2.886E-16 1.001E-14 7.500E-14 2.903E-13 8 30
30 GO:0050820 positive regulation of coagulation 3.885E-16 1.303E-14 9.760E-14 3.908E-13 8 31
31 GO:0090303 positive regulation of wound healing 4.247E-14 1.378E-12 1.033E-11 4.273E-11 8 53
32 GO:0051917 regulation of fibrinolysis 6.905E-14 2.171E-12 1.626E-11 6.946E-11 6 14
33 GO:0006888 ER to Golgi vesicle-mediated transport 5.306E-13 1.618E-11 1.212E-10 5.338E-10 10 178
34 GO:0045861 negative regulation of proteolysis 1.032E-12 3.052E-11 2.287E-10 1.038E-9 12 366
35 GO:0051918 negative regulation of fibrinolysis 3.734E-12 1.073E-10 8.041E-10 3.757E-9 5 10
36 GO:0045055 regulated exocytosis 5.513E-12 1.541E-10 1.154E-9 5.546E-9 11 315
37 GO:0010755 regulation of plasminogen activation 6.837E-12 1.859E-10 1.393E-9 6.878E-9 5 11
38 GO:0030168 platelet activation 1.379E-11 3.650E-10 2.735E-9 1.387E-8 9 168
39 GO:0010757 negative regulation of plasminogen activation 4.622E-11 1.163E-9 8.709E-9 4.650E-8 4 5
40 GO:0007598 blood coagulation, extrinsic pathway 4.622E-11 1.163E-9 8.709E-9 4.650E-8 4 5
41 GO:0006887 exocytosis 1.890E-10 4.637E-9 3.474E-8 1.901E-7 11 438
42 GO:0032103 positive regulation of response to external stimulus 2.259E-10 5.410E-9 4.053E-8 2.272E-7 10 328
43 GO:0048193 Golgi vesicle transport 3.205E-10 7.498E-9 5.617E-8 3.224E-7 10 340
44 GO:0010951 negative regulation of endopeptidase activity 4.014E-10 9.178E-9 6.875E-8 4.038E-7 9 245
45 GO:0010466 negative regulation of peptidase activity 6.126E-10 1.369E-8 1.026E-7 6.163E-7 9 257
46 GO:0052548 regulation of endopeptidase activity 1.305E-9 2.853E-8 2.137E-7 1.312E-6 10 393
47 GO:1903036 positive regulation of response to wounding 1.348E-9 2.885E-8 2.161E-7 1.356E-6 8 188
48 GO:0052547 regulation of peptidase activity 2.256E-9 4.729E-8 3.542E-7 2.270E-6 10 416
49 GO:0030198 extracellular matrix organization 1.010E-8 2.073E-7 1.553E-6 1.016E-5 9 354
50 GO:0043062 extracellular structure organization 1.035E-8 2.082E-7 1.560E-6 1.041E-5 9 355
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 34 input genes in category / 63 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031091 platelet alpha granule 4.331E-19 2.728E-17 1.290E-16 2.728E-17 11 75
2 GO:0034774 secretory granule lumen 1.865E-18 4.395E-17 2.078E-16 1.175E-16 11 85
3 GO:0031093 platelet alpha granule lumen 2.093E-18 4.395E-17 2.078E-16 1.318E-16 10 55
4 GO:0060205 cytoplasmic vesicle lumen 1.909E-17 3.007E-16 1.422E-15 1.203E-15 11 104
5 GO:0031983 vesicle lumen 2.940E-17 3.705E-16 1.752E-15 1.852E-15 11 108
6 GO:0030141 secretory granule 7.852E-14 8.245E-13 3.898E-12 4.947E-12 13 400
7 GO:0005788 endoplasmic reticulum lumen 1.917E-12 1.725E-11 8.159E-11 1.208E-10 10 207
8 GO:0005796 Golgi lumen 5.013E-12 3.948E-11 1.867E-10 3.158E-10 8 96
9 GO:0072562 blood microparticle 1.269E-10 8.880E-10 4.199E-9 7.992E-9 8 143
10 GO:0005577 fibrinogen complex 1.056E-9 6.653E-9 3.146E-8 6.653E-8 4 9
11 GO:0031012 extracellular matrix 5.825E-8 3.336E-7 1.577E-6 3.670E-6 9 444
12 GO:0009897 external side of plasma membrane 1.038E-6 5.450E-6 2.577E-5 6.539E-5 7 310
13 GO:0031233 intrinsic component of external side of plasma membrane 1.217E-3 5.896E-3 2.788E-2
7.664E-2
 2 29
14 GO:0072563 endothelial microparticle 3.564E-3 1.604E-2
7.584E-2
2.246E-1
 1 2
15 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane 5.634E-3 2.366E-2
1.119E-1
3.550E-1
 2 63
16 GO:0030134 COPII-coated ER to Golgi transport vesicle 7.106E-3 2.798E-2
1.323E-1
4.477E-1
 2 71
17 GO:0033093 Weibel-Palade body 8.888E-3 3.132E-2
1.481E-1
5.599E-1
 1 5
18 GO:0030135 coated vesicle 8.948E-3 3.132E-2
1.481E-1
5.637E-1
 3 241
19 GO:0005791 rough endoplasmic reticulum 1.169E-2 3.877E-2
1.833E-1
7.367E-1
 2 92
20 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 1.531E-2 4.565E-2
2.159E-1
9.643E-1
 2 106
21 GO:0031232 extrinsic component of external side of plasma membrane 1.594E-2 4.565E-2
2.159E-1
1.000E0
 1 9
22 GO:0042583 chromaffin granule 1.594E-2 4.565E-2
2.159E-1
1.000E0
 1 9
Show 17 more annotations

4: Human Phenotype [Display Chart] 23 input genes in category / 722 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0010990 Abnormality of the common coagulation pathway 2.777E-22 2.005E-19 1.436E-18 2.005E-19 12 29
2 HP:0002625 Deep venous thrombosis 9.805E-20 3.540E-17 2.534E-16 7.079E-17 13 62
3 HP:0005261 Joint hemorrhage 2.958E-18 7.118E-16 5.097E-15 2.136E-15 9 16
4 HP:0010989 Abnormality of the intrinsic pathway 1.326E-17 2.394E-15 1.714E-14 9.575E-15 12 63
5 HP:0010988 Abnormality of the extrinsic pathway 3.309E-16 4.778E-14 3.421E-13 2.389E-13 9 24
6 HP:0003645 Prolonged partial thromboplastin time 6.169E-16 7.424E-14 5.315E-13 4.454E-13 10 40
7 HP:0005543 Reduced protein C activity 1.038E-15 1.071E-13 7.668E-13 7.497E-13 8 16
8 HP:0005521 Disseminated intravascular coagulation 1.385E-15 1.250E-13 8.949E-13 9.999E-13 10 43
9 HP:0003256 Abnormality of the coagulation cascade 1.656E-15 1.328E-13 9.511E-13 1.195E-12 14 166
10 HP:0004936 Venous thrombosis 2.692E-15 1.601E-13 1.147E-12 1.944E-12 13 130
11 HP:0004418 Thrombophlebitis 2.692E-15 1.601E-13 1.147E-12 1.944E-12 13 130
12 HP:0008321 Reduced factor X activity 2.883E-15 1.601E-13 1.147E-12 2.082E-12 7 10
13 HP:0003225 Reduced coagulation factor V activity 2.883E-15 1.601E-13 1.147E-12 2.082E-12 7 10
14 HP:0008169 Reduced factor VII activity 7.906E-15 3.805E-13 2.725E-12 5.708E-12 7 11
15 HP:0005542 Prolonged whole-blood clotting time 7.906E-15 3.805E-13 2.725E-12 5.708E-12 7 11
16 HP:0030780 Abnormality of the protein C anticoagulant pathway 9.525E-15 4.298E-13 3.078E-12 6.877E-12 9 33
17 HP:0000132 Menorrhagia 3.972E-14 1.687E-12 1.208E-11 2.868E-11 9 38
18 HP:0001977 Abnormal thrombosis 1.380E-13 5.243E-12 3.754E-11 9.962E-11 14 227
19 HP:0001907 Thromboembolism 1.380E-13 5.243E-12 3.754E-11 9.962E-11 14 227
20 HP:0012200 Abnormality of prothrombin 6.098E-13 2.201E-11 1.576E-10 4.403E-10 8 31
21 HP:0000167 Oral bleeding 8.632E-13 2.819E-11 2.018E-10 6.232E-10 9 52
22 HP:0000225 Gingival bleeding 8.632E-13 2.819E-11 2.018E-10 6.232E-10 9 52
23 HP:0000421 Epistaxis 8.979E-13 2.819E-11 2.018E-10 6.483E-10 11 112
24 HP:0004841 Reduced factor XII activity 1.179E-12 3.546E-11 2.539E-10 8.510E-10 7 19
25 HP:0004420 Arterial thrombosis 1.232E-12 3.558E-11 2.547E-10 8.894E-10 10 81
26 HP:0030976 Abnormal factor VIII activity 1.392E-12 3.721E-11 2.664E-10 1.005E-9 8 34
27 HP:0003125 Reduced factor VIII activity 1.392E-12 3.721E-11 2.664E-10 1.005E-9 8 34
28 HP:0002624 Abnormal venous morphology 4.769E-12 1.230E-10 8.804E-10 3.443E-9 14 293
29 HP:0000978 Bruising susceptibility 5.187E-12 1.291E-10 9.246E-10 3.745E-9 11 131
30 HP:0100724 Hypercoagulability 5.645E-12 1.359E-10 9.727E-10 4.076E-9 11 132
31 HP:0012233 Intramuscular hematoma 1.047E-11 2.439E-10 1.747E-9 7.562E-9 5 6
32 HP:0100659 Abnormality of the cerebral vasculature 1.438E-11 3.245E-10 2.323E-9 1.038E-8 16 482
33 HP:0001929 Reduced factor XI activity 1.964E-11 4.297E-10 3.076E-9 1.418E-8 6 14
34 HP:0008151 Prolonged prothrombin time 2.696E-11 5.725E-10 4.099E-9 1.947E-8 7 28
35 HP:0005268 Spontaneous abortion 1.349E-10 2.743E-9 1.964E-8 9.739E-8 9 89
36 HP:0001933 Subcutaneous hemorrhage 1.368E-10 2.743E-9 1.964E-8 9.875E-8 13 299
37 HP:0011029 Internal hemorrhage 1.841E-10 3.592E-9 2.572E-8 1.329E-7 14 383
38 HP:0004855 Reduced protein S activity 1.119E-9 2.127E-8 1.523E-7 8.081E-7 6 25
39 HP:0011901 Dysfibrinogenemia 2.160E-9 3.777E-8 2.704E-7 1.560E-6 4 5
40 HP:0011878 Abnormal platelet membrane protein expression 2.197E-9 3.777E-8 2.704E-7 1.586E-6 5 13
41 HP:0004807 Thrombasthenia 2.197E-9 3.777E-8 2.704E-7 1.586E-6 5 13
42 HP:0001975 Decreased platelet glycoprotein IIb-IIIa 2.197E-9 3.777E-8 2.704E-7 1.586E-6 5 13
43 HP:0001787 Abnormal delivery 2.737E-9 4.595E-8 3.290E-7 1.976E-6 9 124
44 HP:0001934 Persistent bleeding after trauma 3.407E-9 5.590E-8 4.002E-7 2.460E-6 5 14
45 HP:0011869 Abnormal platelet function 5.519E-9 8.854E-8 6.340E-7 3.985E-6 7 57
46 HP:0003010 Prolonged bleeding time 1.958E-8 3.073E-7 2.200E-6 1.414E-5 7 68
47 HP:0004850 Recurrent deep vein thrombosis 7.005E-8 1.057E-6 7.568E-6 5.057E-5 5 24
48 HP:0002170 Intracranial hemorrhage 7.027E-8 1.057E-6 7.568E-6 5.073E-5 9 179
49 HP:0011898 Abnormality of circulating fibrinogen 8.928E-8 1.316E-6 9.419E-6 6.446E-5 4 10
50 HP:0011875 Abnormal platelet morphology 1.318E-7 1.903E-6 1.362E-5 9.514E-5 5 27
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 31 input genes in category / 782 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002551 abnormal blood coagulation 2.099E-26 9.561E-24 6.922E-23 1.642E-23 21 281
2 MP:0009676 abnormal hemostasis 2.445E-26 9.561E-24 6.922E-23 1.912E-23 21 283
3 MP:0001634 internal hemorrhage 2.750E-13 7.167E-11 5.189E-10 2.150E-10 14 347
4 MP:0005048 abnormal thrombosis 1.277E-12 2.496E-10 1.807E-9 9.986E-10 10 122
5 MP:0001915 intracranial hemorrhage 6.892E-8 1.078E-5 7.804E-5 5.389E-5 7 126
6 MP:0003141 cardiac fibrosis 9.799E-8 1.277E-5 9.246E-5 7.663E-5 8 202
7 MP:0005606 increased bleeding time 2.406E-7 2.688E-5 1.946E-4 1.882E-4 6 91
8 MP:0006298 abnormal platelet activation 3.523E-7 3.443E-5 2.493E-4 2.755E-4 6 97
9 MP:0010211 abnormal acute phase protein level 6.698E-7 5.819E-5 4.213E-4 5.237E-4 4 24
10 MP:0003422 abnormal thrombolysis 1.347E-6 1.053E-4 7.625E-4 1.053E-3 3 8
11 MP:0005464 abnormal platelet physiology 1.731E-6 1.231E-4 8.910E-4 1.354E-3 6 127
12 MP:0020148 abnormal sensitivity to induced morbidity/mortality 5.525E-6 3.601E-4 2.607E-3 4.321E-3 9 463
13 MP:0009548 abnormal platelet aggregation 7.024E-6 4.225E-4 3.059E-3 5.493E-3 5 92
14 MP:0009764 decreased sensitivity to induced morbidity/mortality 1.610E-5 8.994E-4 6.511E-3 1.259E-2 5 109
15 MP:0005023 abnormal wound healing 2.578E-5 1.269E-3 9.191E-3 2.016E-2 6 203
16 MP:0020215 impaired blood coagulation 2.597E-5 1.269E-3 9.191E-3 2.031E-2 2 3
17 MP:0003423 reduced thrombolysis 5.185E-5 2.285E-3 1.654E-2 4.055E-2 2 4
18 MP:0004245 genital hemorrhage 5.344E-5 2.285E-3 1.654E-2 4.179E-2 3 25
19 MP:0009549 decreased platelet aggregation 5.552E-5 2.285E-3 1.654E-2 4.341E-2 4 71
20 MP:0003333 liver fibrosis 6.193E-5 2.422E-3 1.753E-2 4.843E-2 4 73
21 MP:0009275 bruising 1.805E-4 6.720E-3 4.865E-2
1.411E-1
 2 7
22 MP:0000249 abnormal blood vessel physiology 1.967E-4 6.898E-3 4.994E-2
1.538E-1
 7 421
23 MP:0001654 hepatic necrosis 2.029E-4 6.898E-3 4.994E-2
1.586E-1
 4 99
24 MP:0012359 increased partial thromboplastin time 2.402E-4 7.464E-3
5.404E-2
1.878E-1
 2 8
25 MP:0003426 pulmonary interstitial fibrosis 2.402E-4 7.464E-3
5.404E-2
1.878E-1
 2 8
26 MP:0005338 atherosclerotic lesions 2.544E-4 7.464E-3
5.404E-2
1.990E-1
 4 105
27 MP:0006050 pulmonary fibrosis 2.577E-4 7.464E-3
5.404E-2
2.015E-1
 3 42
28 MP:0003991 arteriosclerosis 3.041E-4 7.987E-3
5.782E-2
2.378E-1
 4 110
29 MP:0004898 uterine hemorrhage 3.082E-4 7.987E-3
5.782E-2
2.410E-1
 2 9
30 MP:0012357 abnormal partial thromboplastin time 3.082E-4 7.987E-3
5.782E-2
2.410E-1
 2 9
31 MP:0006059 decreased susceptibility to ischemic brain injury 3.166E-4 7.987E-3
5.782E-2
2.476E-1
 3 45
32 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality 3.380E-4 8.261E-3
5.980E-2
2.643E-1
 3 46
33 MP:0003434 decreased susceptibility to induced choroidal neovascularization 4.691E-4 1.112E-2
8.048E-2
3.669E-1
 2 11
34 MP:0011922 abnormal circulating osteocalcin level 5.619E-4 1.292E-2
9.356E-2
4.394E-1
 2 12
35 MP:0005098 abnormal optic choroid morphology 6.049E-4 1.352E-2
9.785E-2
4.730E-1
 3 56
36 MP:0030531 abnormal facial skin morphology 6.628E-4 1.440E-2
1.042E-1
5.183E-1
 2 13
37 MP:0000316 cellular necrosis 7.719E-4 1.631E-2
1.181E-1
6.036E-1
 2 14
38 MP:0011088 neonatal lethality, incomplete penetrance 9.082E-4 1.869E-2
1.353E-1
7.102E-1
 6 390
39 MP:0005546 choroidal neovascularization 1.288E-3 2.583E-2
1.870E-1
1.000E0
 2 18
40 MP:0001876 decreased inflammatory response 1.485E-3 2.903E-2
2.102E-1
1.000E0
 5 287
41 MP:0008734 decreased susceptibility to endotoxin shock 1.708E-3 3.258E-2
2.358E-1
1.000E0
 3 80
42 MP:0002295 abnormal pulmonary circulation 1.770E-3 3.296E-2
2.386E-1
1.000E0
 3 81
43 MP:0003075 altered response to CNS ischemic injury 1.898E-3 3.375E-2
2.443E-1
1.000E0
 3 83
44 MP:0005435 hemoperitoneum 1.930E-3 3.375E-2
2.443E-1
1.000E0
 2 22
45 MP:0008835 abnormal intercellular signaling peptide or protein level 1.942E-3 3.375E-2
2.443E-1
1.000E0
 6 452
46 MP:0011514 skin hemorrhage 2.110E-3 3.438E-2
2.489E-1
1.000E0
 2 23
47 MP:0001656 focal hepatic necrosis 2.110E-3 3.438E-2
2.489E-1
1.000E0
 2 23
48 MP:0006237 abnormal choroid vasculature morphology 2.110E-3 3.438E-2
2.489E-1
1.000E0
 2 23
49 MP:0011506 glomerular crescent 2.298E-3 3.667E-2
2.655E-1
1.000E0
 2 24
50 MP:0002282 abnormal trachea morphology 2.393E-3 3.743E-2
2.710E-1
1.000E0
 3 90
Show 45 more annotations

6: Domain [Display Chart] 34 input genes in category / 242 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00594 Gla Pfam 1.335E-22 6.459E-21 3.919E-20 3.230E-20 9 14
2 IPR000294 GLA domain InterPro 1.335E-22 6.459E-21 3.919E-20 3.230E-20 9 14
3 SM00069 GLA SMART 1.335E-22 6.459E-21 3.919E-20 3.230E-20 9 14
4 PS00011 GLA 1 PROSITE 1.335E-22 6.459E-21 3.919E-20 3.230E-20 9 14
5 PS50998 GLA 2 PROSITE 1.335E-22 6.459E-21 3.919E-20 3.230E-20 9 14
6 IPR017857 Coagulation fac subgr Gla dom InterPro 2.637E-17 9.116E-16 5.532E-15 6.381E-15 7 12
7 4.10.740.10 - Gene3D 2.637E-17 9.116E-16 5.532E-15 6.381E-15 7 12
8 IPR033116 TRYPSIN SER InterPro 3.383E-12 1.023E-10 6.210E-10 8.187E-10 8 90
9 IPR018114 TRYPSIN HIS InterPro 1.021E-11 2.746E-10 1.666E-9 2.471E-9 8 103
10 PS00135 TRYPSIN SER PROSITE 1.290E-11 3.065E-10 1.860E-9 3.123E-9 8 106
11 PS00134 TRYPSIN HIS PROSITE 1.393E-11 3.065E-10 1.860E-9 3.371E-9 8 107
12 IPR023795 Serpin CS InterPro 1.964E-11 3.961E-10 2.404E-9 4.753E-9 6 32
13 IPR001314 Peptidase S1A InterPro 2.171E-11 4.041E-10 2.452E-9 5.253E-9 8 113
14 PS50240 TRYPSIN DOM PROSITE 2.503E-11 4.326E-10 2.625E-9 6.057E-9 8 115
15 SM00020 Tryp SPc SMART 2.878E-11 4.644E-10 2.818E-9 6.966E-9 8 117
16 IPR001254 Trypsin dom InterPro 3.779E-11 5.379E-10 3.264E-9 9.145E-9 8 121
17 PF00089 Trypsin Pfam 3.779E-11 5.379E-10 3.264E-9 9.145E-9 8 121
18 IPR023796 Serpin dom InterPro 4.200E-11 5.460E-10 3.314E-9 1.016E-8 6 36
19 IPR009003 Peptidase S1 PA InterPro 4.315E-11 5.460E-10 3.314E-9 1.044E-8 8 123
20 IPR012224 Pept S1A FX InterPro 4.513E-11 5.460E-10 3.314E-9 1.092E-8 4 5
21 SM00093 SERPIN SMART 5.007E-11 5.508E-10 3.342E-9 1.212E-8 6 37
22 PS00284 SERPIN PROSITE 5.007E-11 5.508E-10 3.342E-9 1.212E-8 6 37
23 PF00008 EGF Pfam 5.242E-11 5.516E-10 3.347E-9 1.269E-8 8 126
24 PF00079 Serpin Pfam 5.938E-11 5.987E-10 3.633E-9 1.437E-8 6 38
25 IPR000215 Serpin fam InterPro 7.009E-11 6.784E-10 4.117E-9 1.696E-8 6 39
26 SM00181 EGF SMART 2.734E-10 2.451E-9 1.487E-8 6.617E-8 9 236
27 PS50026 EGF 3 PROSITE 2.734E-10 2.451E-9 1.487E-8 6.617E-8 9 236
28 IPR000742 EGF-like dom InterPro 4.555E-10 3.937E-9 2.389E-8 1.102E-7 9 250
29 PS00022 EGF 1 PROSITE 5.618E-10 4.688E-9 2.845E-8 1.359E-7 9 256
30 IPR013032 EGF-like CS InterPro 6.893E-10 5.560E-9 3.374E-8 1.668E-7 9 262
31 PS01186 EGF 2 PROSITE 7.878E-10 6.150E-9 3.732E-8 1.906E-7 9 266
32 SM00179 EGF CA SMART 1.941E-9 1.468E-8 8.905E-8 4.696E-7 7 122
33 IPR001881 EGF-like Ca-bd dom InterPro 2.175E-9 1.595E-8 9.680E-8 5.264E-7 7 124
34 IPR018097 EGF Ca-bd CS InterPro 1.970E-8 1.280E-7 7.766E-7 4.768E-6 6 97
35 PS50070 KRINGLE 2 PROSITE 2.115E-8 1.280E-7 7.766E-7 5.119E-6 4 17
36 IPR000001 Kringle InterPro 2.115E-8 1.280E-7 7.766E-7 5.119E-6 4 17
37 IPR018056 Kringle CS InterPro 2.115E-8 1.280E-7 7.766E-7 5.119E-6 4 17
38 PF00051 Kringle Pfam 2.115E-8 1.280E-7 7.766E-7 5.119E-6 4 17
39 PS00021 KRINGLE 1 PROSITE 2.115E-8 1.280E-7 7.766E-7 5.119E-6 4 17
40 SM00130 KR SMART 2.115E-8 1.280E-7 7.766E-7 5.119E-6 4 17
41 PS01187 EGF CA PROSITE 2.229E-8 1.315E-7 7.982E-7 5.393E-6 6 99
42 PS00010 ASX HYDROXYL PROSITE 2.368E-8 1.364E-7 8.279E-7 5.730E-6 6 100
43 IPR000152 EGF-type Asp/Asn hydroxyl site InterPro 3.362E-8 1.892E-7 1.148E-6 8.137E-6 6 106
44 IPR013806 Kringle-like InterPro 3.135E-7 1.724E-6 1.046E-5 7.587E-5 4 32
45 IPR002384 Osteocalcin/MGP InterPro 3.197E-6 1.682E-5 1.021E-4 7.736E-4 2 2
46 IPR024715 Factor 5/8 InterPro 3.197E-6 1.682E-5 1.021E-4 7.736E-4 2 2
47 IPR020837 Fibrinogen CS InterPro 5.187E-6 2.671E-5 1.621E-4 1.255E-3 3 19
48 PF08702 Fib alpha Pfam 9.579E-6 4.636E-5 2.813E-4 2.318E-3 2 3
49 SM01212 Fib alpha SMART 9.579E-6 4.636E-5 2.813E-4 2.318E-3 2 3
50 IPR012290 Fibrinogen a/b/g coil dom InterPro 9.579E-6 4.636E-5 2.813E-4 2.318E-3 2 3
Show 45 more annotations

7: Pathway [Display Chart] 34 input genes in category / 227 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83073 Complement and coagulation cascades BioSystems: KEGG 1.069E-36 2.426E-34 1.457E-33 2.426E-34 20 79
2 P00011 Blood coagulation PantherDB 1.742E-35 1.978E-33 1.187E-32 3.955E-33 17 40
3 1269368 Formation of Fibrin Clot (Clotting Cascade) BioSystems: REACTOME 5.107E-33 3.864E-31 2.320E-30 1.159E-30 16 39
4 SMP00274 Heparin Pathway SMPDB 3.238E-25 6.683E-24 4.013E-23 7.351E-23 11 18
5 SMP00272 Enoxaparin Pathway SMPDB 3.238E-25 6.683E-24 4.013E-23 7.351E-23 11 18
6 SMP00268 Warfarin Pathway SMPDB 3.238E-25 6.683E-24 4.013E-23 7.351E-23 11 18
7 SMP00275 Ardeparin Pathway SMPDB 3.238E-25 6.683E-24 4.013E-23 7.351E-23 11 18
8 SMP00271 Phenprocoumon Pathway SMPDB 3.238E-25 6.683E-24 4.013E-23 7.351E-23 11 18
9 SMP00270 Dicumarol Pathway SMPDB 3.238E-25 6.683E-24 4.013E-23 7.351E-23 11 18
10 SMP00269 Acenocoumarol Pathway SMPDB 3.238E-25 6.683E-24 4.013E-23 7.351E-23 11 18
11 SMP00273 Fondaparinux Pathway SMPDB 3.238E-25 6.683E-24 4.013E-23 7.351E-23 11 18
12 M4470 Extrinsic Prothrombin Activation Pathway MSigDB C2 BIOCARTA (v6.0) 1.518E-24 2.872E-23 1.725E-22 3.447E-22 10 13
13 1269371 Common Pathway of Fibrin Clot Formation BioSystems: REACTOME 7.130E-24 1.245E-22 7.475E-22 1.618E-21 11 22
14 M15997 Intrinsic Prothrombin Activation Pathway MSigDB C2 BIOCARTA (v6.0) 1.364E-23 2.212E-22 1.328E-21 3.097E-21 11 23
15 1268704 Gamma-carboxylation of protein precursors BioSystems: REACTOME 2.651E-23 4.012E-22 2.409E-21 6.019E-21 9 10
16 SMP00276 Argatroban Pathway SMPDB 1.025E-22 1.225E-21 7.356E-21 2.328E-20 10 17
17 SMP00277 Bivalirudin Pathway SMPDB 1.025E-22 1.225E-21 7.356E-21 2.328E-20 10 17
18 SMP00279 Ximelagatran Pathway SMPDB 1.025E-22 1.225E-21 7.356E-21 2.328E-20 10 17
19 SMP00278 Lepirudin Pathway SMPDB 1.025E-22 1.225E-21 7.356E-21 2.328E-20 10 17
20 1268703 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins BioSystems: REACTOME 1.456E-22 1.652E-21 9.920E-21 3.304E-20 9 11
21 1269370 Intrinsic Pathway of Fibrin Clot Formation BioSystems: REACTOME 3.379E-21 3.653E-20 2.193E-19 7.671E-19 10 22
22 1268705 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus BioSystems: REACTOME 1.142E-20 1.127E-19 6.767E-19 2.592E-18 8 9
23 PW:0000474 coagulation cascade Pathway Ontology 1.142E-20 1.127E-19 6.767E-19 2.592E-18 8 9
24 SMP00282 Streptokinase Pathway SMPDB 3.000E-20 2.128E-19 1.278E-18 6.811E-18 9 16
25 SMP00287 Tranexamic Acid Pathway SMPDB 3.000E-20 2.128E-19 1.278E-18 6.811E-18 9 16
26 SMP00283 Tenecteplase Pathway SMPDB 3.000E-20 2.128E-19 1.278E-18 6.811E-18 9 16
27 SMP00286 Aminocaproic Acid Pathway SMPDB 3.000E-20 2.128E-19 1.278E-18 6.811E-18 9 16
28 SMP00285 Reteplase Pathway SMPDB 3.000E-20 2.128E-19 1.278E-18 6.811E-18 9 16
29 SMP00288 Aprotinin Pathway SMPDB 3.000E-20 2.128E-19 1.278E-18 6.811E-18 9 16
30 SMP00284 Urokinase Pathway SMPDB 3.000E-20 2.128E-19 1.278E-18 6.811E-18 9 16
31 SMP00281 Anistreplase Pathway SMPDB 3.000E-20 2.128E-19 1.278E-18 6.811E-18 9 16
32 SMP00280 Alteplase Pathway SMPDB 3.000E-20 2.128E-19 1.278E-18 6.811E-18 9 16
33 1268706 Removal of aminoterminal propeptides from gamma-carboxylated proteins BioSystems: REACTOME 5.699E-20 3.920E-19 2.354E-18 1.294E-17 8 10
34 M15394 Acute Myocardial Infarction MSigDB C2 BIOCARTA (v6.0) 4.373E-19 2.920E-18 1.753E-17 9.927E-17 9 20
35 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v6.0) 1.438E-17 9.328E-17 5.601E-16 3.265E-15 15 238
36 M2842 Fibrinolysis Pathway MSigDB C2 BIOCARTA (v6.0) 4.595E-16 2.898E-15 1.740E-14 1.043E-13 7 12
37 1268702 Gamma carboxylation, hypusine formation and arylsulfatase activation BioSystems: REACTOME 5.331E-16 3.260E-15 1.957E-14 1.210E-13 9 39
38 1269367 Platelet degranulation BioSystems: REACTOME 5.457E-16 3.260E-15 1.957E-14 1.239E-13 12 132
39 1269365 Response to elevated platelet cytosolic Ca2+ BioSystems: REACTOME 8.621E-16 5.018E-15 3.013E-14 1.957E-13 12 137
40 P00050 Plasminogen activating cascade PantherDB 1.118E-14 6.343E-14 3.809E-13 2.537E-12 7 17
41 1269350 Platelet activation, signaling and aggregation BioSystems: REACTOME 1.903E-13 1.053E-12 6.325E-12 4.319E-11 13 282
42 1269372 Dissolution of Fibrin Clot BioSystems: REACTOME 1.416E-10 7.651E-10 4.594E-9 3.214E-8 5 13
43 M6487 Platelet Amyloid Precursor Protein Pathway MSigDB C2 BIOCARTA (v6.0) 2.198E-10 1.160E-9 6.967E-9 4.989E-8 5 14
44 1269369 Extrinsic Pathway of Fibrin Clot Formation BioSystems: REACTOME 2.313E-10 1.193E-9 7.165E-9 5.250E-8 4 5
45 PW:0000480 protein C anticoagulant Pathway Ontology 6.926E-10 3.494E-9 2.098E-8 1.572E-7 4 6
46 M3008 Genes encoding structural ECM glycoproteins MSigDB C2 BIOCARTA (v6.0) 8.081E-7 3.988E-6 2.394E-5 1.834E-4 7 196
47 1269358 Platelet Aggregation (Plug Formation) BioSystems: REACTOME 3.204E-6 1.547E-5 9.291E-5 7.273E-4 4 38
48 M5884 Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans MSigDB C2 BIOCARTA (v6.0) 7.670E-6 3.627E-5 2.178E-4 1.741E-3 7 275
49 1269361 p130Cas linkage to MAPK signaling for integrins BioSystems: REACTOME 1.017E-5 4.618E-5 2.773E-4 2.309E-3 3 16
50 1269360 GRB2:SOS provides linkage to MAPK signaling for Integrins BioSystems: REACTOME 1.017E-5 4.618E-5 2.773E-4 2.309E-3 3 16
Show 45 more annotations

8: Pubmed [Display Chart] 34 input genes in category / 12531 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11154109 Early embryonic expression of murine coagulation system components. Pubmed 6.864E-53 8.602E-49 8.613E-48 8.602E-49 19 32
2 14718574 The human plasma proteome: a nonredundant list developed by combination of four separate sources. Pubmed 2.457E-34 1.540E-30 1.542E-29 3.079E-30 18 166
3 16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Pubmed 1.465E-28 6.119E-25 6.127E-24 1.836E-24 17 257
4 18974842 Gender differences in genetic risk profiles for cardiovascular disease. Pubmed 5.933E-25 1.859E-21 1.861E-20 7.434E-21 11 46
5 20673868 A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Pubmed 3.278E-24 7.397E-21 7.407E-20 4.108E-20 14 186
6 20452482 Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. Pubmed 3.542E-24 7.397E-21 7.407E-20 4.438E-20 14 187
7 20128871 Gene variants associated with venous thrombosis: confirmation in the MEGA study. Pubmed 7.990E-23 1.430E-19 1.432E-18 1.001E-18 8 12
8 16466010 [Pharmacogenetics of the local thrombolysis in patients with deep vein thrombosis]. Pubmed 3.121E-19 4.889E-16 4.895E-15 3.911E-15 6 6
9 18057060 Fibrinogen Aalpha Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension. Pubmed 2.183E-18 3.040E-15 3.044E-14 2.736E-14 6 7
10 10391209 Characterization of single-nucleotide polymorphisms in coding regions of human genes. Pubmed 4.552E-18 5.705E-15 5.712E-14 5.705E-14 9 67
11 12615788 No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age. Pubmed 2.617E-17 2.755E-14 2.758E-13 3.279E-13 6 9
12 18977990 Candidate genes and cerebral palsy: a population-based study. Pubmed 2.638E-17 2.755E-14 2.758E-13 3.306E-13 7 21
13 12871600 Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. Pubmed 3.867E-17 3.727E-14 3.732E-13 4.845E-13 7 22
14 20036902 Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction. Pubmed 6.538E-17 5.852E-14 5.859E-13 8.192E-13 6 10
15 16839353 Traces of factor VIIa modulate thromboplastin sensitivity to factors V, VII, X, and prothrombin. Pubmed 4.110E-16 3.029E-13 3.033E-12 5.150E-12 5 5
16 18284606 Polymorphisms in coagulation factors and the risk of recurrent cardiovascular events in men after a first myocardial infarction. Pubmed 4.110E-16 3.029E-13 3.033E-12 5.150E-12 5 5
17 11157667 Mouse carotid artery ligation induces platelet-leukocyte-dependent luminal fibrin, required for neointima development. Pubmed 4.110E-16 3.029E-13 3.033E-12 5.150E-12 5 5
18 18848323 Prothrombotic genetic variants and atherosclerosis in patients with cerebral ischemia of arterial origin. Pubmed 5.332E-16 3.712E-13 3.717E-12 6.682E-12 6 13
19 19238444 The genomic basis of cerebral palsy: a HuGE systematic literature review. Pubmed 1.211E-15 7.985E-13 7.995E-12 1.517E-11 7 34
20 21724997 Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica. Pubmed 2.464E-15 1.482E-12 1.484E-11 3.088E-11 5 6
21 20532885 Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders. Pubmed 2.484E-15 1.482E-12 1.484E-11 3.112E-11 6 16
22 19004141 Thrombophilia and unexplained pregnancy loss in Indian patients. Pubmed 8.620E-15 4.321E-12 4.326E-11 1.080E-10 5 7
23 19682239 Replication of findings on the association of genetic variation in 24 hemostasis genes and risk of incident venous thrombosis. Pubmed 8.620E-15 4.321E-12 4.326E-11 1.080E-10 5 7
24 15968394 Polymorphisms in prothrombotic genes and their impact on ischemic stroke in a Sardinian population. Pubmed 8.620E-15 4.321E-12 4.326E-11 1.080E-10 5 7
25 29321368 VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo. Pubmed 8.620E-15 4.321E-12 4.326E-11 1.080E-10 5 7
26 19578796 Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. Pubmed 9.493E-15 4.575E-12 4.581E-11 1.190E-10 9 152
27 17107352 ABO blood group but not haemostasis genetic polymorphisms significantly influence thrombotic risk: a study of 180 homozygotes for the Factor V Leiden mutation. Pubmed 2.297E-14 1.066E-11 1.068E-10 2.879E-10 5 8
28 16944957 Proteome-wide characterization of N-glycosylation events by diagonal chromatography. Pubmed 4.508E-14 2.017E-11 2.020E-10 5.649E-10 7 55
29 19560472 Clinical factors such as B-type natriuretic peptide link to factor VII, endothelial NO synthase and estrogen receptor alpha polymorphism in elderly women. Pubmed 1.032E-13 4.461E-11 4.467E-10 1.294E-9 5 10
30 14645112 Evidence for similar expression of protein C inhibitor and the urokinase-type plasminogen activator system during mouse testis development. Pubmed 1.892E-13 7.901E-11 7.911E-10 2.370E-9 5 11
31 23750785 Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry. Pubmed 2.782E-13 1.125E-10 1.126E-9 3.487E-9 6 32
32 23294934 A new regulatory function of activated factor V: inhibition of the activation by tissue factor/factor VII(a) of factor X. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
33 7989361 The mechanism of inactivation of human factor V and human factor Va by activated protein C. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
34 28729433 Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
35 16935856 Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
36 18198180 Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
37 18253477 Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
38 18424440 Detailed mechanisms of the inactivation of factor VIIIa by activated protein C in the presence of its cofactors, protein S and factor V. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
39 9701458 Renal expression of fibrinolytic genes and tissue factor in a murine model of renal disease as a function of age. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
40 10891445 Vascular release of plasminogen activator inhibitor-1 impairs fibrinolysis during acute arterial thrombosis in mice. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
41 19526059 Polymorphic variation of genes in the fibrinolytic system and the risk of ovarian cancer. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
42 10026263 Factor VIIa/tissue factor generates a form of factor V with unchanged specific activity, resistance to activation by thrombin, and increased sensitivity to activated protein C. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
43 18064331 The influence of established genetic variation in the haemostatic system on clinical restenosis after percutaneous coronary interventions. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
44 15978566 Protein S and protein C gene mutations in Japanese deep vein thrombosis patients. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
45 17890957 Haemostatic changes and acquired activated protein C resistance in normal pregnancy. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
46 12859287 Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction. Pubmed 5.232E-13 1.403E-10 1.405E-9 6.556E-9 4 4
47 17003923 Gene polymorphisms implicated in influencing susceptibility to venous and arterial thromboembolism: frequency distribution in a healthy German population. Pubmed 5.263E-13 1.403E-10 1.405E-9 6.595E-9 5 13
48 28327460 Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Pubmed 1.171E-12 3.057E-10 3.061E-9 1.467E-8 7 86
49 14746139 Molecular variation at functional genes and the history of human populations--data on candidate genes for cardiovascular risk in the Mediterranean. Pubmed 1.226E-12 3.136E-10 3.140E-9 1.537E-8 5 15
50 24172014 Update of the human and mouse SERPIN gene superfamily. Pubmed 1.859E-12 4.659E-10 4.665E-9 2.329E-8 6 43
Show 45 more annotations

9: Interaction [Display Chart] 34 input genes in category / 688 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:F2 F2 interactions 1.037E-31 7.135E-29 5.074E-28 7.135E-29 15 44
2 int:F10 F10 interactions 1.850E-20 6.363E-18 4.525E-17 1.273E-17 9 20
3 int:GGCX GGCX interactions 1.562E-15 3.583E-13 2.548E-12 1.075E-12 7 18
4 int:F8 F8 interactions 2.470E-15 4.249E-13 3.022E-12 1.699E-12 7 19
5 int:PLG PLG interactions 4.435E-15 6.103E-13 4.340E-12 3.051E-12 9 67
6 int:SERPINA5 SERPINA5 interactions 2.585E-13 2.964E-11 2.108E-10 1.778E-10 7 34
7 int:PROS1 PROS1 interactions 3.839E-13 3.773E-11 2.683E-10 2.641E-10 6 17
8 int:PROC PROC interactions 8.393E-13 6.793E-11 4.831E-10 5.775E-10 6 19
9 int:PLAT PLAT interactions 8.887E-13 6.793E-11 4.831E-10 6.114E-10 7 40
10 int:PLAU PLAU interactions 2.754E-11 1.895E-9 1.348E-8 1.895E-8 6 32
11 int:F5 F5 interactions 1.617E-10 1.012E-8 7.194E-8 1.113E-7 5 18
12 int:F7 F7 interactions 2.919E-10 1.673E-8 1.190E-7 2.008E-7 5 20
13 int:SERPINB6 SERPINB6 interactions 1.228E-9 6.500E-8 4.623E-7 8.450E-7 5 26
14 int:FGA FGA interactions 5.139E-9 2.525E-7 1.796E-6 3.536E-6 5 34
15 int:F9 F9 interactions 9.219E-9 4.229E-7 3.007E-6 6.343E-6 5 38
16 int:KLK2 KLK2 interactions 6.630E-8 2.851E-6 2.027E-5 4.561E-5 4 21
17 int:SERPINE1 SERPINE1 interactions 1.645E-7 6.657E-6 4.734E-5 1.132E-4 4 26
18 int:SERPINE2 SERPINE2 interactions 2.247E-7 8.587E-6 6.107E-5 1.546E-4 4 28
19 int:ELANE ELANE interactions 3.439E-7 1.245E-5 8.855E-5 2.366E-4 4 31
20 int:F13A1 F13A1 interactions 2.322E-6 7.608E-5 5.411E-4 1.598E-3 3 14
21 int:F3 F3 interactions 2.322E-6 7.608E-5 5.411E-4 1.598E-3 3 14
22 int:ADAMTS13 ADAMTS13 interactions 3.580E-6 1.120E-4 7.963E-4 2.463E-3 2 2
23 int:GP1BA GP1BA interactions 4.321E-6 1.293E-4 9.192E-4 2.973E-3 3 17
24 int:APOH APOH interactions 5.179E-6 1.485E-4 1.056E-3 3.563E-3 3 18
25 int:SERPINF2 SERPINF2 interactions 7.216E-6 1.986E-4 1.412E-3 4.964E-3 3 20
26 int:ITGA2B ITGA2B interactions 8.407E-6 2.225E-4 1.582E-3 5.784E-3 3 21
27 int:VWF VWF interactions 9.722E-6 2.443E-4 1.738E-3 6.689E-3 3 22
28 int:CALR CALR interactions 9.943E-6 2.443E-4 1.738E-3 6.841E-3 5 152
29 int:LRP2 LRP2 interactions 1.389E-5 3.296E-4 2.344E-3 9.559E-3 4 77
30 int:NID1 NID1 interactions 2.536E-5 5.817E-4 4.137E-3 1.745E-2 3 30
31 int:ALB ALB interactions 4.927E-5 1.093E-3 7.776E-3 3.390E-2 5 212
32 int:SERPIND1 SERPIND1 interactions 5.345E-5 1.114E-3 7.924E-3 3.677E-2 2 6
33 int:KLK13 KLK13 interactions 5.345E-5 1.114E-3 7.924E-3 3.677E-2 2 6
34 int:CTSG CTSG interactions 6.092E-5 1.233E-3 8.766E-3 4.191E-2 3 40
35 int:THBD THBD interactions 9.953E-5 1.851E-3 1.316E-2
6.847E-2
 2 8
36 int:CPB2 CPB2 interactions 9.953E-5 1.851E-3 1.316E-2
6.847E-2
 2 8
37 int:SERPINA10 SERPINA10 interactions 9.953E-5 1.851E-3 1.316E-2
6.847E-2
 2 8
38 int:PDGFC PDGFC interactions 1.278E-4 2.255E-3 1.603E-2
8.793E-2
 2 9
39 int:BGLAP BGLAP interactions 1.278E-4 2.255E-3 1.603E-2
8.793E-2
 2 9
40 int:LRP1 LRP1 interactions 1.367E-4 2.351E-3 1.672E-2
9.406E-2
 4 138
41 int:ALDH2 ALDH2 interactions 1.420E-4 2.383E-3 1.695E-2
9.769E-2
 3 53
42 int:F11 F11 interactions 1.948E-4 3.117E-3 2.217E-2
1.340E-1
 2 11
43 int:LPA LPA interactions 1.948E-4 3.117E-3 2.217E-2
1.340E-1
 2 11
44 int:KLK6 KLK6 interactions 3.701E-4 5.787E-3 4.115E-2
2.546E-1
 2 15
45 int:SNX27 SNX27 interactions 4.807E-4 7.349E-3
5.226E-2
3.307E-1
 3 80
46 int:SERPINC1 SERPINC1 interactions 5.373E-4 8.037E-3
5.715E-2
3.697E-1
 2 18
47 int:SERPING1 SERPING1 interactions 6.657E-4 9.744E-3
6.930E-2
4.580E-1
 2 20
48 int:IGFBP5 IGFBP5 interactions 7.349E-4 1.053E-2
7.491E-2
5.056E-1
 2 21
49 int:F12 F12 interactions 8.832E-4 1.240E-2
8.819E-2
6.076E-1
 2 23
50 int:SERPINB8 SERPINB8 interactions 1.219E-3 1.678E-2
1.193E-1
8.390E-1
 2 27
Show 45 more annotations

10: Cytoband [Display Chart] 34 input genes in category / 31 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 13q34 13q34 2.840E-5 5.189E-4 2.090E-3 8.804E-4 3 60
2 4q28 4q28 3.348E-5 5.189E-4 2.090E-3 1.038E-3 2 9
3 2q13-q14 2q13-q14 9.809E-4 1.014E-2 4.082E-2 3.041E-2 1 1
4 4q12-q13 4q12-q13 1.961E-3 1.216E-2 4.896E-2
6.079E-2
 1 2
5 Xq27.1-q27.2 Xq27.1-q27.2 1.961E-3 1.216E-2 4.896E-2
6.079E-2
 1 2
6 1p36.3-p36.2 1p36.3-p36.2 3.918E-3 2.022E-2
8.145E-2
1.215E-1
 1 4
7 1p22-p21 1p22-p21 4.895E-3 2.022E-2
8.145E-2
1.518E-1
 1 5
8 11p11 11p11 5.872E-3 2.022E-2
8.145E-2
1.820E-1
 1 6
9 5q33 5q33 5.872E-3 2.022E-2
8.145E-2
1.820E-1
 1 6
10 10p15 10p15 6.847E-3 2.123E-2
8.548E-2
2.123E-1
 1 7
11 18q21.33 18q21.33 1.751E-2 4.936E-2
1.988E-1
5.430E-1
 1 18
12 4q27 4q27 2.137E-2 4.944E-2
1.991E-1
6.623E-1
 1 22
13 2q36.1 2q36.1 2.137E-2 4.944E-2
1.991E-1
6.623E-1
 1 22
14 1q23 1q23 2.233E-2 4.944E-2
1.991E-1
6.921E-1
 1 23
Show 9 more annotations

11: Transcription Factor Binding Site [Display Chart] 30 input genes in category / 96 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 27 input genes in category / 10 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1250 Gla domain containing genenames.org 5.622E-31 5.622E-30 1.647E-29 5.622E-30 11 13
2 739 Serpin peptidase inhibitors genenames.org 1.326E-11 6.629E-11 1.942E-10 1.326E-10 6 37
3 542 Endogenous ligands genenames.org 1.080E-6 3.598E-6 1.054E-5 1.080E-5 6 237
4 554 Fibrinogen C domain containing|Fibronectin type III domain containing genenames.org 6.559E-6 1.640E-5 4.803E-5 6.559E-5 3 25
5 404 Annexins genenames.org 1.913E-2 3.825E-2
1.120E-1
1.913E-1
 1 13
6 50 ADAM metallopeptidases with thrombospondin type 1 motif genenames.org 2.784E-2 3.840E-2
1.125E-1
2.784E-1
 1 19
7 405 Apolipoproteins genenames.org 3.072E-2 3.840E-2
1.125E-1
3.072E-1
 1 21
8 1321 Carboxypeptidases genenames.org 3.072E-2 3.840E-2
1.125E-1
3.072E-1
 1 21
Show 3 more annotations

13: Coexpression [Display Chart] 34 input genes in category / 3288 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13283 Liver selective genes MSigDB C2: CGP Curated Gene Sets (v6.0) 2.175E-29 7.152E-26 6.204E-25 7.152E-26 19 244
2 M5946 Genes encoding components of blood coagulation system; also up-regulated in platelets. MSigDB H: Hallmark Gene Sets (v6.0) 3.313E-25 5.446E-22 4.725E-21 1.089E-21 15 138
3 18318837-Table1 Human MesenchymalStemCells Yamamoto08 83genes GeneSigDB 1.929E-15 2.114E-12 1.834E-11 6.342E-12 9 79
4 M6175 Genes down-regulated at early fetal liver stage (embryonic days E11.5 - E12.5) compared to the late fetal liver stage (embryonic days E14.5 - E16.5). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.166E-14 9.588E-12 8.318E-11 3.835E-11 11 222
5 M5921 Genes encoding components of the complement system, which is part of the innate immune system. MSigDB H: Hallmark Gene Sets (v6.0) 2.034E-13 1.338E-10 1.160E-9 6.688E-10 10 200
6 19061838-TableS13 Mouse Viral Cairo08 620genes GeneSigDB 2.774E-11 1.520E-8 1.319E-7 9.119E-8 10 328
7 12176889-Table1 Human Lung Dekker02 68genes GeneSigDB 3.664E-10 1.721E-7 1.493E-6 1.205E-6 6 62
8 M7054 Genes up-regulated specifically in human liver tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.663E-8 6.837E-6 5.931E-5 5.469E-5 5 55
9 M1286 Genes from 'subtype S3' signature of hepatocellular carcinoma (HCC): hepatocyte differentiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.012E-7 3.698E-5 3.209E-4 3.329E-4 7 266
10 M1806 Direct targets of FOXA2 [GeneID=3170] in liver, according to a ChIP-chip analysis. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.450E-7 4.768E-5 4.136E-4 4.768E-4 8 425
11 16509772-TableS1 Human StemCell Coller06 136genes GeneSigDB 1.810E-7 5.409E-5 4.693E-4 5.950E-4 5 88
12 19171046-tableS1b Human Liver Dong09 120genes GeneSigDB 2.657E-7 7.280E-5 6.316E-4 8.736E-4 5 95
13 15735721-Table3 Human Lung Dauer05 137genes GeneSigDB 4.814E-7 1.218E-4 1.056E-3 1.583E-3 5 107
14 M12112 Angiogenic markers up-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.086E-6 9.596E-4 8.325E-3 1.343E-2 5 165
15 M2769 Genes down-regulated during early stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v6.0) 5.005E-6 1.034E-3 8.972E-3 1.646E-2 5 172
16 14768006-Table2 Human Breast Kim04 30genes GeneSigDB 5.032E-6 1.034E-3 8.972E-3 1.655E-2 3 23
17 15642130-TableS1 Rat Immune Rioja04 438genes GeneSigDB 7.081E-6 1.275E-3 1.106E-2 2.328E-2 6 325
18 M6145 Genes highly expressed in hepatocellular carcinoma with good survival. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.137E-6 1.275E-3 1.106E-2 2.347E-2 5 185
19 15994966-Table2 Human Sarcoma Detwiller05 33genes GeneSigDB 7.366E-6 1.275E-3 1.106E-2 2.422E-2 3 26
20 15735721-SuppTable1a Human Lung Dauer05 200genes GeneSigDB 8.989E-6 1.478E-3 1.282E-2 2.955E-2 5 194
21 17575140-Table1 Human Prostate Verona07 41genes GeneSigDB 2.003E-5 3.135E-3 2.720E-2
6.584E-2
 3 36
22 16138077-Table3 Mouse Liver Gresh05 62genes GeneSigDB 2.177E-5 3.194E-3 2.771E-2
7.158E-2
 3 37
23 M5451 Survival signature genes defined in adjacent liver tissue: genes correlated with good survival of hepatocellular carcinoma (HCC) patients. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.234E-5 3.194E-3 2.771E-2
7.345E-2
 4 113
24 M12398 Genes up-regulated by hypoxia in RCC4 cells (renal cell carcinoma) engineered to stably express VHL [GeneID=7428] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.132E-5 4.200E-3 3.643E-2
1.030E-1
 2 6
25 16495925-Table3 Human Breast Lombaerts06 43genes TGBFb GeneSigDB 3.200E-5 4.200E-3 3.643E-2
1.052E-1
 3 42
26 15958557-TableS1 Mouse StemCell KronesHerzig05 145enes GeneSigDB 3.321E-5 4.200E-3 3.643E-2
1.092E-1
 4 125
27 15606925-Table3 Human Breast Bieche04 47genes GeneSigDB 4.215E-5 5.133E-3 4.453E-2
1.386E-1
 3 46
28 M19432 Genes up-regulated during pubertal mammary gland development between week 4 and 5. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.477E-5 5.257E-3 4.561E-2
1.472E-1
 5 271
29 11884566-Table4 Human Lymphoma Poole02 54genes GeneSigDB 4.793E-5 5.434E-3 4.714E-2
1.576E-1
 3 48
30 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.013E-5 5.494E-3 4.766E-2
1.648E-1
 6 460
31 20460173-ImmPortAntimicrobials Human Immune Kong10 544genes ImmPort Antimicrobials GeneSigDB 5.581E-5 5.772E-3
5.007E-2
1.835E-1
 6 469
32 15260889-TableS2b Human Breast Dairkee04 202genes GeneSigDB 5.617E-5 5.772E-3
5.007E-2
1.847E-1
 4 143
33 17161497-SuppTable1 Human Lung Dracheva07 162genes GeneSigDB 6.090E-5 5.899E-3
5.117E-2
2.002E-1
 4 146
34 16585153-Table1 Mouse Skin Hagendoorn06 54genes GeneSigDB 6.099E-5 5.899E-3
5.117E-2
2.005E-1
 3 52
35 16455954-Table2 Human StemCell Dekker06 107genes GeneSigDB 6.832E-5 6.418E-3
5.568E-2
2.246E-1
 3 54
36 M19097 Genes up-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.192E-5 6.568E-3
5.698E-2
2.365E-1
 6 491
37 18226221-Table2 Human Brain Terragni08 12genes GeneSigDB 7.497E-5 6.662E-3
5.780E-2
2.465E-1
 2 9
38 19731222-Table4 Human ChorionicVilliSamples Farina09 10genes GeneSigDB 9.363E-5 7.899E-3
6.852E-2
3.078E-1
 2 10
39 M16524 Genes up-regulated in hepatocellular carcinoma (HCC) induced by diethylnitrosamine (DENA) [PubChem=5921]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.369E-5 7.899E-3
6.852E-2
3.081E-1
 3 60
40 M1626 Cluster 1: genes progressively down-regulated over 24 h (peak at 0 h timepoint) during differentiation of 3T3-L1 fibroblasts into adipocytes in response to adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.084E-4 8.742E-3
7.584E-2
3.564E-1
 3 63
41 M1576 Selected genes down-regulated during differentiation of 3T3-L1 cells (fibroblast) into adipocytes in response to adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.136E-4 8.742E-3
7.584E-2
3.736E-1
 3 64
42 M1192 Genes up-regulated in MDA-MB-231 cells (breast cancer, mutated TP53 [GeneID=7157]) undergoing mitotic arrest and apoptosis after treatment with 100 nM docetaxel [PubChem=148124]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.136E-4 8.742E-3
7.584E-2
3.736E-1
 3 64
43 15643601-Table6 Human Pancreas Centeno05 11genes GeneSigDB 1.143E-4 8.742E-3
7.584E-2
3.759E-1
 2 11
44 16367923-Table2 Human Stomach Yamashita06 68genes GeneSigDB 1.302E-4 9.589E-3
8.319E-2
4.282E-1
 3 67
45 M16932 Top 200 marker genes down-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation, high levels of serum AFP [GeneID=174], and chromosomal instability. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.340E-4 9.589E-3
8.319E-2
4.406E-1
 4 179
46 M18168 Genes up-regulated in MEF cells (embryonic fibroblast) isolated from NRAS [GeneID=4893] knockout mice. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.361E-4 9.589E-3
8.319E-2
4.475E-1
 3 68
47 15246160-table5 Human StemCell Shim04 12genes GeneSigDB 1.371E-4 9.589E-3
8.319E-2
4.507E-1
 2 12
48 17170073-TableS3 Mouse StemCell zurNieden07 81genes GeneSigDB 1.484E-4 1.016E-2
8.817E-2
4.879E-1
 3 70
49 M19476 Genes up-regulated in dividing CD34+ [GeneID=8842] cells isolated from peripheral blood of CML (chronic myeloid leukemia) patients compared to the dividing cells from normal donors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.618E-4 1.051E-2
9.122E-2
5.321E-1
 2 13
50 17327601-Table3 Human Colon DelRio07 14genes GeneSigDB 1.618E-4 1.051E-2
9.122E-2
5.321E-1
 2 13
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 34 input genes in category / 2741 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 liver liver Human Protein Atlas 8.172E-21 2.240E-17 1.902E-16 2.240E-17 17 419
2 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver Tabula Muris Consortium 6.214E-20 8.517E-17 7.234E-16 1.703E-16 13 156
3 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 500 k2 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.185E-19 3.824E-16 3.248E-15 1.147E-15 14 246
4 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 1000 k4 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.100E-18 2.809E-15 2.386E-14 1.124E-14 15 379
5 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 500 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.147E-17 5.680E-15 4.824E-14 3.144E-14 15 406
6 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 200 k3 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.243E-17 5.680E-15 4.824E-14 3.408E-14 11 114
7 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 200 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 6.586E-16 2.579E-13 2.190E-12 1.805E-12 11 162
8 Facebase ST1 Univ 500 UniversalReference WholeMouseP1 top-relative-expression-ranked 500 FaceBase_ST1 9.476E-16 3.247E-13 2.758E-12 2.597E-12 14 427
9 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Intrahepatic/5 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Intrahepatic/5 TCGA-Bile Duct 1.220E-14 3.715E-12 3.156E-11 3.344E-11 9 91
10 BM Top 100 - liver BM Top 100 - liver Body Map 3.818E-13 1.047E-10 8.889E-10 1.047E-9 8 80
11 Facebase ST1 Univ 250 UniversalReference WholeMouseP1 top-relative-expression-ranked 250 FaceBase_ST1 4.843E-13 1.207E-10 1.025E-9 1.327E-9 10 206
12 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 100 k2 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.934E-12 4.418E-10 3.752E-9 5.301E-9 7 54
13 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Hilar/Perihilar/5 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Hilar/Perihilar/5 TCGA-Bile Duct 2.884E-12 5.647E-10 4.796E-9 7.906E-9 9 165
14 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/hepatocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/hepatocyte Tabula Muris Consortium 2.884E-12 5.647E-10 4.796E-9 7.906E-9 9 165
15 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 100 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 3.373E-11 6.163E-9 5.234E-8 9.244E-8 7 80
16 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 1000 k4 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.195E-10 2.046E-8 1.738E-7 3.274E-7 6 49
17 gudmap developingKidney e15.5 early proxim tubul 1000 k1 DevelopingKidney e15.5 early proxim tubul emap-28005 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.620E-10 7.449E-8 6.327E-7 1.266E-6 8 192
18 GSM777043 100 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 8.006E-9 1.207E-6 1.025E-5 2.195E-5 6 97
19 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Embryonal Carcinoma, Mature Teratoma, Yolk Sac Tumor/6 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Embryonal Carcinoma, Mature Teratoma, Yolk Sac Tumor/6 TCGA-Testes 8.457E-9 1.207E-6 1.025E-5 2.318E-5 7 175
20 gudmap developingLowerUrinaryTract e15.5 Urothelium 500 k4 DevelopingLowerUrinaryTract e15.5 Urothelium emap-28091 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.807E-9 1.207E-6 1.025E-5 2.414E-5 4 16
21 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 1.633E-8 2.074E-6 1.762E-5 4.476E-5 9 438
22 ratio EB-blastocyst vs EB-cbCD34 500 K1 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 500 k-means-cluster#1 PCBC 1.665E-8 2.074E-6 1.762E-5 4.563E-5 7 193
23 PCBC ratio EB-blastocyst vs EB-cbCD34 500 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 500 PCBC 3.992E-8 4.758E-6 4.041E-5 1.094E-4 9 486
24 gudmap developingLowerUrinaryTract e15.5 Urothelium 1000 k2 DevelopingLowerUrinaryTract e15.5 Urothelium emap-28091 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 9.778E-8 1.117E-5 9.485E-5 2.680E-4 4 28
25 gudmap developingKidney e15.5 early proxim tubul 500 DevelopingKidney e15.5 early proxim tubul emap-28005 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.239E-7 1.359E-5 1.154E-4 3.397E-4 8 393
26 gudmap developingKidney e15.5 early proxim tubul 500 k3 DevelopingKidney e15.5 early proxim tubul emap-28005 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.399E-7 1.475E-5 1.253E-4 3.836E-4 5 79
27 Facebase ST1 Univ 100 UniversalReference WholeMouseP1 top-relative-expression-ranked 100 FaceBase_ST1 1.906E-7 1.935E-5 1.644E-4 5.225E-4 5 84
28 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Yolk Sac Tumor/6 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Yolk Sac Tumor/6 TCGA-Testes 2.720E-7 2.662E-5 2.261E-4 7.455E-4 6 175
29 ratio EB-blastocyst vs EB-cbCD34 1000 K2 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 1000 k-means-cluster#2 PCBC 3.087E-7 2.918E-5 2.478E-4 8.461E-4 7 296
30 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 3.194E-7 2.919E-5 2.479E-4 8.756E-4 8 445
31 PCBC ratio EB bone marrow vs EB blastocyst cfr-2X-p05 EB bone marrow vs EB blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 3.780E-7 3.343E-5 2.839E-4 1.036E-3 8 455
32 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Limb Muscle/mesenchymal stem cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Limb Muscle/mesenchymal stem cell Tabula Muris Consortium 4.412E-7 3.779E-5 3.210E-4 1.209E-3 6 190
33 Facebase ST1 Univ 500 4 UniversalReference WholeMouseP1 top-relative-expression-ranked 500 4 FaceBase_ST1 9.095E-7 7.554E-5 6.416E-4 2.493E-3 6 215
34 PCBC ratio MESO-30 from-ESC vs MESO-30 from-plasmid cfr-2X-p05 Mesoderm Day 30-method NA vs Mesoderm Day 30-method plasmid-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.506E-6 1.147E-4 9.739E-4 4.128E-3 7 375
35 PCBC ratio MESO-30 blastocyst vs MESO-30 fibroblast cfr-2X-p05 MESO-30 blastocyst vs MESO-30 fibroblast-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.506E-6 1.147E-4 9.739E-4 4.128E-3 7 375
36 PCBC ratio MESO-30 from-ESC vs MESO-30 from-OSKM - NLT cfr-2X-p05 Mesoderm Day 30-reprogram NA vs Mesoderm Day 30-reprogram OSKM - NLT-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.506E-6 1.147E-4 9.739E-4 4.128E-3 7 375
37 gudmap developingLowerUrinaryTract e15.5 urothelium 500 DevelopingLowerUrinaryTract e15.5 Urothelium emap-28091 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.126E-6 1.575E-4 1.338E-3 5.827E-3 7 395
38 GSM538239 500 Myeloid Cells, DC.103-11b+.Lv, CD45+ CD11c+ MHC-II + CD11b high CD103-, Liver, avg-3 Immgen.org, GSE15907 2.764E-6 1.994E-4 1.694E-3 7.577E-3 7 411
39 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Intrahepatic/5/2 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Intrahepatic/5/2 TCGA-Bile Duct 4.800E-6 3.374E-4 2.865E-3 1.316E-2 5 161
40 Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma Heterologous Type/4/1 Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma Heterologous Type/4/1 TCGA-Uterus 6.440E-6 4.412E-4 3.748E-3 1.765E-2 5 171
41 PCBC ratio EB blastocyst vs EB amniotic fluid MSC cfr-2X-p05 EB blastocyst vs EB amniotic fluid MSC-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 6.600E-6 4.412E-4 3.748E-3 1.809E-2 6 303
42 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 500 k3 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.759E-6 5.716E-4 4.855E-3 2.401E-2 3 26
43 PCBC EB fibroblast 500 Progenitor-Cell-Biology-Consortium EmbryoidBody from inducedPluripotentialStemCells derived from from fibroblast top-relative-expression-ranked 500 PCBC 9.852E-6 6.280E-4 5.334E-3 2.700E-2 7 499
44 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Tumour Wilms Junk/Kidney Tumour Wilms IT26 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Tumour Wilms Junk/Kidney Tumour Wilms IT26 Adult, Development, and Cancer types 1.159E-5 7.085E-4 6.018E-3 3.177E-2 5 193
45 BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip. .Dcn Endothelial Tip. .Dcn Subtype Endothelial Tip. .Dcn.Mgp Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip. .Dcn Endothelial Tip. .Dcn Subtype Endothelial Tip. .Dcn.Mgp Top 200 Genes BrainMap 1.189E-5 7.085E-4 6.018E-3 3.259E-2 6 336
46 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Endothelial Tip Subtype Dcn.Mgp Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Endothelial Tip Subtype Dcn.Mgp Top 200 Genes 1.189E-5 7.085E-4 6.018E-3 3.259E-2 6 336
47 gudmap developingLowerUrinaryTract e15.5 Urothelium 200 k2 DevelopingLowerUrinaryTract e15.5 Urothelium emap-28091 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.410E-5 8.224E-4 6.985E-3 3.865E-2 2 4
48 Facebase ST1 Univ 500 2 UniversalReference WholeMouseP1 top-relative-expression-ranked 500 2 FaceBase_ST1 1.824E-5 1.042E-3 8.848E-3
5.000E-2
 3 33
49 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Embryonal Carcinoma/6 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Embryonal Carcinoma/6 TCGA-Testes 2.899E-5 1.622E-3 1.377E-2
7.946E-2
 4 114
50 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal RCC PT-U/Kidney Normal RCC PT4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal RCC PT-U/Kidney Normal RCC PT4 Adult, Development, and Cancer types 3.518E-5 1.929E-3 1.638E-2
9.644E-2
 2 6
Show 45 more annotations

15: Computational [Display Chart] 31 input genes in category / 184 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M8116 MODULE 131 Blood coagulation factors. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.793E-31 6.980E-29 4.045E-28 6.980E-29 15 33
2 M6913 CAR HPX Neighborhood of HPX MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.074E-13 5.588E-11 3.238E-10 1.118E-10 9 73
3 M5702 MODULE 24 Fetal liver genes - metabolism and xenobiotics. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.565E-11 9.596E-10 5.561E-9 2.879E-9 14 453
4 M14108 GNF2 HPX Neighborhood of HPX MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.728E-10 6.819E-9 3.952E-8 3.180E-8 9 135
5 M15716 MODULE 209 Catabolic peptidases. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.853E-10 6.819E-9 3.952E-8 3.410E-8 8 89
6 M6257 MODULE 164 Enzyme inhibitors (esp serine proteases). MSigDb: C4 - CM: Cancer Modules (v6.0) 5.041E-10 1.546E-8 8.959E-8 9.276E-8 7 61
7 M13003 MODULE 109 Serine proteases. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.579E-9 4.150E-8 2.405E-7 2.905E-7 6 39
8 M17376 MODULE 107 Genes in the cancer module 107. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.225E-9 7.418E-8 4.298E-7 5.934E-7 7 79
9 M10917 GNF2 HPN Neighborhood of HPN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.697E-9 9.602E-8 5.564E-7 8.642E-7 8 133
10 M10041 MODULE 172 Genes in the cancer module 172. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.279E-8 2.354E-7 1.364E-6 2.354E-6 7 96
11 M17919 GNF2 TST Neighborhood of TST MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.242E-8 3.751E-7 2.174E-6 4.126E-6 7 104
12 M10693 GNF2 GSTM1 Neighborhood of GSTM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.112E-8 4.772E-7 2.765E-6 5.726E-6 7 109
13 M132 GNF2 LCAT Neighborhood of LCAT MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.617E-8 1.078E-6 6.248E-6 1.402E-5 7 124
14 M18034 CAR IGFBP1 Neighborhood of IGFBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.497E-7 9.853E-6 5.710E-5 1.379E-4 5 57
15 M19409 GNF2 CYP2B6 Neighborhood of CYP2B6 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.432E-5 1.756E-4 1.018E-3 2.634E-3 4 49
16 M3221 GNF2 CEBPA Neighborhood of CEBPA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.157E-5 4.780E-4 2.770E-3 7.649E-3 4 64
17 M4515 MODULE 324 Metal / Ca ion binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.881E-5 5.283E-4 3.061E-3 8.981E-3 5 133
18 M15983 MODULE 46 Genes in the cancer module 46. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.581E-4 1.616E-3 9.364E-3 2.909E-2 7 394
19 M12401 MODULE 75 Immune response. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.683E-4 1.630E-3 9.445E-3 3.097E-2 7 398
20 M18183 MODULE 121 Genes in the cancer module 121. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.284E-4 2.101E-3 1.218E-2 4.203E-2 4 99
21 M6482 MODULE 108 Genes in the cancer module 108. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.620E-4 5.800E-3 3.361E-2
1.218E-1
 3 56
22 M1653 MODULE 223 Immune (defense) response. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.979E-4 7.510E-3 4.352E-2
1.652E-1
 4 142
23 M3341 MODULE 311 Genes in the cancer module 311. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.370E-3 1.096E-2
6.350E-2
2.520E-1
 2 18
24 M17027 MODULE 573 Cell cycle regulators and carbohydrate transporters. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.650E-3 2.032E-2
1.177E-1
4.876E-1
 2 25
25 M17677 GNF2 CDH3 Neighborhood of CDH3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.088E-3 2.262E-2
1.311E-1
5.683E-1
 2 27
26 M9365 GNF2 SERPINB5 Neighborhood of SERPINB5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.320E-3 2.262E-2
1.311E-1
6.108E-1
 2 28
27 M19777 MODULE 385 Heparin binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.320E-3 2.262E-2
1.311E-1
6.108E-1
 2 28
28 M16395 MODULE 47 ECM and collagens. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.810E-3 3.161E-2
1.832E-1
8.851E-1
 4 225
Show 23 more annotations

16: MicroRNA [Display Chart] 34 input genes in category / 598 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-224-5p:Functional MTI Functional MTI miRTarbase 3.423E-5 1.115E-2
7.773E-2
 2.047E-2 3 132
2 hsa-miR-204-5p:Functional MTI Functional MTI miRTarbase 3.729E-5 1.115E-2
7.773E-2
 2.230E-2 4 399
3 hsa-miR-181c-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.057E-4 2.107E-2
1.469E-1
6.321E-2
 2 32
4 hsa-miR-6832-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.805E-4 4.193E-2
2.923E-1
1.677E-1
 3 269
5 hsa-miR-6812-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.685E-4 4.576E-2
3.190E-1
3.400E-1
 2 74
6 hsa-miR-3975:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.639E-4 4.576E-2
3.190E-1
3.970E-1
 2 80
7 hsa-miR-1539:mirSVR lowEffct hsa-miR-1539:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 7.312E-4 4.576E-2
3.190E-1
4.372E-1
 3 374
8 hsa-miR-328:mirSVR highEffct hsa-miR-328:mirSVR conserved highEffect-0.5 MicroRNA.org 9.068E-4 4.576E-2
3.190E-1
5.423E-1
 3 403
9 hsa-miR-3191-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.146E-4 4.576E-2
3.190E-1
5.469E-1
 2 94
10 hsa-miR-1251:mirSVR highEffct hsa-miR-1251:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.199E-4 4.576E-2
3.190E-1
5.501E-1
 3 405
11 hsa-miR-193b:mirSVR highEffct hsa-miR-193b:mirSVR conserved highEffect-0.5 MicroRNA.org 1.028E-3 4.576E-2
3.190E-1
6.149E-1
 3 421
12 hsa-miR-302d-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.248E-3 4.576E-2
3.190E-1
7.466E-1
 2 110
13 hsa-miR-409-3p:Functional MTI Functional MTI miRTarbase 1.271E-3 4.576E-2
3.190E-1
7.601E-1
 2 111
14 hsa-miR-720:mirSVR highEffct hsa-miR-720:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.271E-3 4.576E-2
3.190E-1
7.601E-1
 2 111
15 hsa-miR-302b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.317E-3 4.576E-2
3.190E-1
7.874E-1
 2 113
16 hsa-miR-1306:mirSVR lowEffct hsa-miR-1306:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.350E-3 4.576E-2
3.190E-1
8.075E-1
 3 463
17 hsa-miR-6890-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.384E-3 4.576E-2
3.190E-1
8.276E-1
 3 467
18 hsa-miR-193a-3p:mirSVR highEffct hsa-miR-193a-3p:mirSVR conserved highEffect-0.5 MicroRNA.org 1.409E-3 4.576E-2
3.190E-1
8.429E-1
 3 470
19 hsa-miR-330-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.557E-3 4.576E-2
3.190E-1
9.308E-1
 2 123
20 hsa-miR-769-3p:mirSVR highEffct hsa-miR-769-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.606E-3 4.576E-2
3.190E-1
9.603E-1
 3 492
21 hsa-miR-6890-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.607E-3 4.576E-2
3.190E-1
9.609E-1
 2 125
Show 16 more annotations

17: Drug [Display Chart] 34 input genes in category / 9765 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000003821 ketamine Stitch 4.595E-42 4.487E-38 4.381E-37 4.487E-38 25 262
2 CID000040973 desogestrel Stitch 1.066E-41 5.206E-38 5.083E-37 1.041E-37 21 106
3 CID000002232 1dwc Stitch 7.204E-39 2.345E-35 2.289E-34 7.035E-35 17 45
4 CID000439822 D-Phe-Pro-Arg-CMK Stitch 1.848E-37 4.511E-34 4.405E-33 1.805E-33 16 38
5 CID000005526 tranexamic acid Stitch 8.889E-36 1.736E-32 1.695E-31 8.680E-32 17 64
6 ctd:C442659 ethinyl estradiol-desogestrel combination CTD 1.662E-33 2.705E-30 2.641E-29 1.623E-29 14 30
7 CID000183797 melagatran Stitch 4.318E-32 6.024E-29 5.882E-28 4.217E-28 14 36
8 ctd:C033273 Gestodene CTD 1.295E-31 1.581E-28 1.543E-27 1.264E-27 13 26
9 CID009543487 C4 m Stitch 1.738E-31 1.886E-28 1.841E-27 1.697E-27 16 79
10 CID000002999 AC-474 Stitch 3.911E-31 3.820E-28 3.729E-27 3.820E-27 15 59
11 CID000027991 DDAVP Stitch 1.841E-30 1.635E-27 1.596E-26 1.798E-26 17 123
12 CID000040772 gamma-carboxyglutamic acid Stitch 1.268E-29 1.032E-26 1.007E-25 1.238E-25 16 101
13 CID000123853 S-2238 Stitch 2.853E-29 2.143E-26 2.092E-25 2.785E-25 13 36
14 CID000000564 EACA Stitch 7.375E-29 5.144E-26 5.023E-25 7.202E-25 17 151
15 CID003036757 PPACK Stitch 8.712E-29 5.671E-26 5.537E-25 8.507E-25 16 113
16 CID000008172 triethylene glycol Stitch 1.085E-27 6.623E-25 6.467E-24 1.060E-23 14 67
17 CID000408771 AC1L8VGH Stitch 7.732E-27 4.441E-24 4.337E-23 7.551E-23 13 52
18 CID000124997 S 2251 Stitch 7.119E-26 3.862E-23 3.771E-22 6.952E-22 12 40
19 CID000122261 EGRck Stitch 9.881E-26 4.910E-23 4.794E-22 9.649E-22 11 26
20 CID000133189 Phe-pro-arg Stitch 1.006E-25 4.910E-23 4.794E-22 9.819E-22 12 41
21 ctd:C454300 estradiol valerate-dienogest CTD 1.125E-25 5.234E-23 5.110E-22 1.099E-21 9 10
22 CID000039042 bezafibrate Stitch 3.009E-25 1.336E-22 1.304E-21 2.938E-21 17 242
23 CID000066005 inogatran Stitch 6.960E-25 2.955E-22 2.885E-21 6.797E-21 11 30
24 CID000002332 benzamidine Stitch 1.081E-24 4.398E-22 4.294E-21 1.056E-20 15 147
25 ctd:C035276 eicosapentaenoic acid ethyl ester CTD 1.130E-24 4.413E-22 4.309E-21 1.103E-20 10 19
26 CID000000778 homocysteine Stitch 1.557E-24 5.846E-22 5.708E-21 1.520E-20 17 266
27 CID000162656 L-Phe-pro Stitch 7.014E-24 2.537E-21 2.477E-20 6.849E-20 12 56
28 CID005494422 2bub Stitch 2.918E-23 1.018E-20 9.938E-20 2.850E-19 11 40
29 ctd:D003276 Contraceptives, Oral CTD 5.605E-23 1.887E-20 1.843E-19 5.474E-19 9 15
30 CID000157849 N-acetyl-S-(propionamide)cysteine Stitch 1.591E-22 5.179E-20 5.057E-19 1.554E-18 10 28
31 CID000123687 S-2648 Stitch 2.185E-22 6.882E-20 6.719E-19 2.133E-18 11 47
32 CID000091577 AC1L3MCS Stitch 3.636E-22 1.110E-19 1.083E-18 3.551E-18 10 30
33 CID000004413 nafamostat mesilate Stitch 4.531E-22 1.341E-19 1.309E-18 4.424E-18 12 77
34 CID000005832 norethisterone acetate Stitch 4.672E-22 1.342E-19 1.310E-18 4.562E-18 11 50
35 CID000002949 NSC-270916 Stitch 1.017E-21 2.837E-19 2.770E-18 9.930E-18 12 82
36 CID000189147 S 2160 Stitch 1.872E-21 5.077E-19 4.957E-18 1.828E-17 9 20
37 CID000446515 T-NK Stitch 2.211E-21 5.835E-19 5.698E-18 2.159E-17 10 35
38 CID000005936 diisopropylfluorophosphate Stitch 2.794E-21 7.179E-19 7.009E-18 2.728E-17 16 321
39 CID005460240 tungstopterin Stitch 3.305E-21 8.275E-19 8.079E-18 3.227E-17 13 131
40 CID000123610 Integrilin Stitch 4.187E-21 1.022E-18 9.981E-18 4.089E-17 10 37
41 CID000000323 coumarin Stitch 7.357E-21 1.710E-18 1.670E-17 7.184E-17 13 139
42 CID000002806 PCR 4099 Stitch 7.357E-21 1.710E-18 1.670E-17 7.184E-17 13 139
43 CID000007835 chloromethyl Stitch 8.162E-21 1.854E-18 1.810E-17 7.970E-17 14 195
44 CID000004812 Vitamin K1-d7 Stitch 1.016E-20 2.255E-18 2.202E-17 9.922E-17 10 40
45 DB00170 Menadione Drug Bank 1.267E-20 2.749E-18 2.684E-17 1.237E-16 8 13
46 CID000005472 ticlopidine Stitch 1.842E-20 3.827E-18 3.737E-17 1.799E-16 12 103
47 CID005327302 Inhibitor 3 Stitch 1.842E-20 3.827E-18 3.737E-17 1.799E-16 12 103
48 CID000220862 NSC4322 Stitch 2.241E-20 4.560E-18 4.452E-17 2.189E-16 11 69
49 CID009574101 ximelagatran Stitch 2.292E-20 4.567E-18 4.459E-17 2.238E-16 10 43
50 CID000010439 2-aminopyridine Stitch 2.657E-20 5.189E-18 5.066E-17 2.594E-16 11 70
Show 45 more annotations

18: Disease [Display Chart] 34 input genes in category / 1501 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0398623 Thrombophilia DisGeNET Curated 3.806E-38 5.713E-35 4.509E-34 5.713E-35 20 86
2 C0584960 Factor V Leiden mutation DisGeNET BeFree 1.174E-28 8.809E-26 6.951E-25 1.762E-25 15 61
3 C0040053 Thrombosis DisGeNET Curated 2.282E-28 1.142E-25 9.008E-25 3.425E-25 14 45
4 C0005779 Blood Coagulation Disorders DisGeNET Curated 5.734E-28 2.152E-25 1.698E-24 8.607E-25 18 160
5 C0149871 Deep Vein Thrombosis DisGeNET Curated 1.620E-26 4.865E-24 3.839E-23 2.432E-23 15 82
6 C0034065 Pulmonary Embolism DisGeNET Curated 1.507E-24 3.771E-22 2.976E-21 2.262E-21 13 55
7 C0018924 Hemarthrosis DisGeNET Curated 1.358E-23 2.911E-21 2.297E-20 2.038E-20 9 11
8 C0012739 Disseminated Intravascular Coagulation DisGeNET Curated 9.150E-22 1.717E-19 1.355E-18 1.373E-18 11 39
9 C0040038 Thromboembolism DisGeNET Curated 1.229E-21 2.049E-19 1.617E-18 1.844E-18 9 15
10 C0042487 Venous Thrombosis DisGeNET Curated 7.217E-21 1.018E-18 8.033E-18 1.083E-17 11 46
11 C0600433 Activated Protein C Resistance DisGeNET Curated 7.460E-21 1.018E-18 8.033E-18 1.120E-17 10 29
12 C0948008 Ischemic stroke DisGeNET Curated 1.292E-19 1.616E-17 1.276E-16 1.940E-16 17 368
13 C1861172 Venous Thromboembolism DisGeNET Curated 7.390E-19 8.533E-17 6.734E-16 1.109E-15 7 8
14 C0240671 Partial thromboplastin time increased (finding) DisGeNET Curated 3.035E-17 3.254E-15 2.568E-14 4.556E-14 7 11
15 C0553681 Hypofibrinogenemia DisGeNET Curated 4.833E-17 4.837E-15 3.817E-14 7.255E-14 8 22
16 C3272363 Ischemic Cerebrovascular Accident DisGeNET BeFree 6.398E-17 6.002E-15 4.736E-14 9.603E-14 15 340
17 C0014591 Epistaxis DisGeNET Curated 1.331E-16 1.176E-14 9.277E-14 1.998E-13 9 43
18 C0311370 Lupus anticoagulant disorder DisGeNET BeFree 1.628E-16 1.357E-14 1.071E-13 2.443E-13 8 25
19 C0242666 Protein S Deficiency DisGeNET Curated 3.332E-16 2.632E-14 2.077E-13 5.001E-13 8 27
20 C0025323 Menorrhagia DisGeNET Curated 1.773E-15 1.331E-13 1.050E-12 2.661E-12 7 17
21 C0085278 Antiphospholipid Syndrome DisGeNET BeFree 5.712E-15 4.083E-13 3.222E-12 8.574E-12 8 37
22 C0019069 Hemophilia A DisGeNET Curated 2.118E-13 1.445E-11 1.140E-10 3.179E-10 9 93
23 C0151945 Thrombosis of cerebral veins DisGeNET Curated 9.761E-13 6.370E-11 5.027E-10 1.465E-9 6 18
24 C0019087 Hemorrhagic Disorders DisGeNET Curated 1.358E-12 8.493E-11 6.702E-10 2.038E-9 7 39
25 C0751956 Acute Cerebrovascular Accidents DisGeNET BeFree 1.979E-12 1.188E-10 9.377E-10 2.971E-9 7 41
26 C0151699 Intracranial Hemorrhages DisGeNET Curated 3.972E-12 2.293E-10 1.809E-9 5.961E-9 7 45
27 C0272375 Antithrombin III Deficiency DisGeNET Curated 5.268E-12 2.929E-10 2.311E-9 7.908E-9 6 23
28 C0002895 Anemia, Sickle Cell DisGeNET Curated 1.028E-11 5.509E-10 4.348E-9 1.543E-8 10 209
29 C0684275 Hemophilia, NOS DisGeNET BeFree 1.333E-11 6.901E-10 5.446E-9 2.001E-8 7 53
30 C0151563 Coagulation time prolonged DisGeNET Curated 1.615E-11 8.078E-10 6.375E-9 2.424E-8 4 4
31 C1704436 Peripheral Arterial Diseases DisGeNET Curated 3.462E-11 1.676E-9 1.323E-8 5.197E-8 8 104
32 C1273976 First myocardial infarction DisGeNET BeFree 5.906E-11 2.770E-9 2.186E-8 8.865E-8 5 14
33 C0423798 Increased tendency to bruise DisGeNET Curated 7.370E-11 3.254E-9 2.568E-8 1.106E-7 7 67
34 C0013491 Ecchymosis DisGeNET Curated 7.370E-11 3.254E-9 2.568E-8 1.106E-7 7 67
35 C0015519 Factor X Deficiency DisGeNET Curated 8.061E-11 3.361E-9 2.652E-8 1.210E-7 4 5
36 C0852077 Blood Coagulation Disorders, Inherited DisGeNET Curated 8.061E-11 3.361E-9 2.652E-8 1.210E-7 4 5
37 C2717961 Thrombotic Microangiopathies DisGeNET Curated 8.322E-11 3.376E-9 2.664E-8 1.249E-7 6 35
38 C2584409 Prothrombin G20210A mutation DisGeNET BeFree 8.845E-11 3.494E-9 2.757E-8 1.328E-7 5 15
39 C0398625 Protein C Deficiency DisGeNET Curated 9.971E-11 3.838E-9 3.028E-8 1.497E-7 6 36
40 C0085409 Polyendocrinopathies, Autoimmune DisGeNET Curated 2.008E-10 7.537E-9 5.948E-8 3.015E-7 7 77
41 C1844374 Persistent bleeding after trauma DisGeNET Curated 2.415E-10 8.630E-9 6.810E-8 3.625E-7 4 6
42 C0015503 Factor VII Deficiency DisGeNET Curated 2.415E-10 8.630E-9 6.810E-8 3.625E-7 4 6
43 C0008533 Hemophilia B DisGeNET Curated 2.662E-10 9.291E-9 7.332E-8 3.995E-7 6 42
44 C0948441 Venoocclusive disease DisGeNET BeFree 3.405E-10 1.161E-8 9.166E-8 5.110E-7 5 19
45 C0034341 Pyruvate Carboxylase Deficiency Disease DisGeNET Curated 3.571E-10 1.176E-8 9.282E-8 5.360E-7 6 44
46 C0040034 Thrombocytopenia DisGeNET Curated 3.605E-10 1.176E-8 9.282E-8 5.411E-7 10 300
47 C1282971 von Willebrand Disease, Type 2B DisGeNET Curated 5.626E-10 1.797E-8 1.418E-7 8.445E-7 4 7
48 C0032962 Pregnancy Complications DisGeNET Curated 6.122E-10 1.915E-8 1.511E-7 9.190E-7 7 90
49 C0598608 Hyperhomocysteinemia DisGeNET Curated 6.623E-10 2.029E-8 1.601E-7 9.941E-7 7 91
50 C0155626 Acute myocardial infarction DisGeNET BeFree 1.394E-9 4.184E-8 3.302E-7 2.092E-6 9 246
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