Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc223_8, positive side

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1: GO: Molecular Function [Display Chart] 8 input genes in category / 30 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005125 cytokine activity 1.239E-8 3.717E-7 1.485E-6 3.717E-7 5 222
2 GO:0005126 cytokine receptor binding 4.640E-8 6.960E-7 2.780E-6 1.392E-6 5 289
3 GO:0008083 growth factor activity 4.112E-7 4.112E-6 1.643E-5 1.233E-5 4 166
4 GO:0070851 growth factor receptor binding 2.399E-5 1.799E-4 7.188E-4 7.197E-4 3 143
5 GO:0005142 interleukin-11 receptor binding 4.287E-4 2.144E-3 8.563E-3 1.286E-2 1 1
6 GO:0038164 thrombopoietin receptor activity 4.287E-4 2.144E-3 8.563E-3 1.286E-2 1 1
7 GO:0004896 cytokine receptor activity 6.320E-4 2.572E-3 1.027E-2 1.896E-2 2 90
8 GO:0042020 interleukin-23 receptor activity 8.572E-4 2.572E-3 1.027E-2 2.572E-2 1 2
9 GO:0042019 interleukin-23 binding 8.572E-4 2.572E-3 1.027E-2 2.572E-2 1 2
10 GO:0005135 interleukin-3 receptor binding 8.572E-4 2.572E-3 1.027E-2 2.572E-2 1 2
11 GO:0005179 hormone activity 1.195E-3 3.214E-3 1.284E-2 3.584E-2 2 124
12 GO:0005128 erythropoietin receptor binding 1.286E-3 3.214E-3 1.284E-2 3.857E-2 1 3
13 GO:0005173 stem cell factor receptor binding 1.714E-3 3.955E-3 1.580E-2
5.142E-2
 1 4
14 GO:0005143 interleukin-12 receptor binding 2.142E-3 4.590E-3 1.834E-2
6.426E-2
 1 5
15 GO:0005088 Ras guanyl-nucleotide exchange factor activity 4.102E-3 8.203E-3 3.277E-2
1.231E-1
 2 232
16 GO:0005085 guanyl-nucleotide exchange factor activity 7.030E-3 1.282E-2
5.123E-2
2.109E-1
 2 306
17 GO:0048018 receptor ligand activity 7.266E-3 1.282E-2
5.123E-2
2.180E-1
 1 17
18 GO:0030546 receptor activator activity 1.491E-2 2.485E-2
9.927E-2
4.473E-1
 1 35
19 GO:0005109 frizzled binding 1.618E-2 2.554E-2
1.020E-1
4.853E-1
 1 38
20 GO:0030545 receptor regulator activity 2.166E-2 3.249E-2
1.298E-1
6.498E-1
 1 51
21 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 2.628E-2 3.754E-2
1.500E-1
7.883E-1
 1 62
22 GO:0052813 phosphatidylinositol bisphosphate kinase activity 3.046E-2 4.120E-2
1.646E-1
9.138E-1
 1 72
23 GO:0035004 phosphatidylinositol 3-kinase activity 3.254E-2 4.120E-2
1.646E-1
9.763E-1
 1 77
24 GO:0030295 protein kinase activator activity 3.296E-2 4.120E-2
1.646E-1
9.888E-1
 1 78
25 GO:0019209 kinase activator activity 3.629E-2 4.354E-2
1.740E-1
1.000E0
 1 86
26 GO:0019955 cytokine binding 4.332E-2 4.999E-2
1.997E-1
1.000E0
 1 103
Show 21 more annotations

2: GO: Biological Process [Display Chart] 8 input genes in category / 596 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030099 myeloid cell differentiation 1.269E-11 7.565E-9 5.272E-8 7.565E-9 7 388
2 GO:0070665 positive regulation of leukocyte proliferation 1.684E-9 5.017E-7 3.496E-6 1.003E-6 5 149
3 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 4.011E-9 7.968E-7 5.552E-6 2.390E-6 5 177
4 GO:0070663 regulation of leukocyte proliferation 1.595E-8 2.206E-6 1.537E-5 9.508E-6 5 233
5 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 1.850E-8 2.206E-6 1.537E-5 1.103E-5 5 240
6 GO:0045639 positive regulation of myeloid cell differentiation 3.362E-8 3.339E-6 2.327E-5 2.004E-5 4 89
7 GO:0070661 leukocyte proliferation 7.795E-8 6.637E-6 4.625E-5 4.646E-5 5 320
8 GO:0018108 peptidyl-tyrosine phosphorylation 1.958E-7 1.330E-5 9.271E-5 1.167E-4 5 385
9 GO:0018212 peptidyl-tyrosine modification 2.009E-7 1.330E-5 9.271E-5 1.197E-4 5 387
10 GO:0038163 thrombopoietin-mediated signaling pathway 4.843E-7 2.887E-5 2.011E-4 2.887E-4 2 3
11 GO:1903708 positive regulation of hemopoiesis 7.268E-7 3.938E-5 2.744E-4 4.332E-4 4 191
12 GO:0045637 regulation of myeloid cell differentiation 9.643E-7 4.123E-5 2.873E-4 5.747E-4 4 205
13 GO:0070666 regulation of mast cell proliferation 9.684E-7 4.123E-5 2.873E-4 5.772E-4 2 4
14 GO:0070668 positive regulation of mast cell proliferation 9.684E-7 4.123E-5 2.873E-4 5.772E-4 2 4
15 GO:0002763 positive regulation of myeloid leukocyte differentiation 1.506E-6 5.984E-5 4.170E-4 8.975E-4 3 57
16 GO:0070662 mast cell proliferation 1.614E-6 6.011E-5 4.189E-4 9.618E-4 2 5
17 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 2.041E-6 7.157E-5 4.987E-4 1.217E-3 3 63
18 GO:1902035 positive regulation of hematopoietic stem cell proliferation 2.420E-6 8.013E-5 5.584E-4 1.442E-3 2 6
19 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 3.750E-6 1.176E-4 8.196E-4 2.235E-3 3 77
20 GO:0007260 tyrosine phosphorylation of STAT protein 4.370E-6 1.302E-4 9.075E-4 2.605E-3 3 81
21 GO:0046427 positive regulation of JAK-STAT cascade 5.236E-6 1.419E-4 9.885E-4 3.121E-3 3 86
22 GO:1904894 positive regulation of STAT cascade 5.236E-6 1.419E-4 9.885E-4 3.121E-3 3 86
23 GO:1902033 regulation of hematopoietic stem cell proliferation 5.804E-6 1.504E-4 1.048E-3 3.459E-3 2 9
24 GO:0045740 positive regulation of DNA replication 6.848E-6 1.700E-4 1.185E-3 4.081E-3 3 94
25 GO:1903706 regulation of hemopoiesis 1.008E-5 2.402E-4 1.674E-3 6.005E-3 4 370
26 GO:0072091 regulation of stem cell proliferation 1.129E-5 2.589E-4 1.804E-3 6.730E-3 3 111
27 GO:0002761 regulation of myeloid leukocyte differentiation 1.575E-5 3.476E-4 2.422E-3 9.385E-3 3 124
28 GO:0050671 positive regulation of lymphocyte proliferation 2.314E-5 4.926E-4 3.432E-3 1.379E-2 3 141
29 GO:0032946 positive regulation of mononuclear cell proliferation 2.414E-5 4.961E-4 3.457E-3 1.439E-2 3 143
30 GO:0033033 negative regulation of myeloid cell apoptotic process 2.751E-5 5.466E-4 3.809E-3 1.640E-2 2 19
31 GO:1902107 positive regulation of leukocyte differentiation 3.131E-5 6.019E-4 4.195E-3 1.866E-2 3 156
32 GO:0046425 regulation of JAK-STAT cascade 3.377E-5 6.099E-4 4.250E-3 2.013E-2 3 160
33 GO:1904892 regulation of STAT cascade 3.377E-5 6.099E-4 4.250E-3 2.013E-2 3 160
34 GO:0072089 stem cell proliferation 3.906E-5 6.848E-4 4.772E-3 2.328E-2 3 168
35 GO:0006275 regulation of DNA replication 4.190E-5 7.136E-4 4.972E-3 2.498E-2 3 172
36 GO:0071425 hematopoietic stem cell proliferation 4.436E-5 7.344E-4 5.117E-3 2.644E-2 2 24
37 GO:0007259 JAK-STAT cascade 5.550E-5 8.704E-4 6.065E-3 3.308E-2 3 189
38 GO:0097696 STAT cascade 5.550E-5 8.704E-4 6.065E-3 3.308E-2 3 189
39 GO:0035162 embryonic hemopoiesis 6.518E-5 9.908E-4 6.904E-3 3.885E-2 2 29
40 GO:0051054 positive regulation of DNA metabolic process 6.864E-5 9.908E-4 6.904E-3 4.091E-2 3 203
41 GO:0042104 positive regulation of activated T cell proliferation 6.982E-5 9.908E-4 6.904E-3 4.161E-2 2 30
42 GO:0033032 regulation of myeloid cell apoptotic process 6.982E-5 9.908E-4 6.904E-3 4.161E-2 2 30
43 GO:0002573 myeloid leukocyte differentiation 8.142E-5 1.129E-3 7.864E-3 4.853E-2 3 215
44 GO:0050670 regulation of lymphocyte proliferation 8.836E-5 1.197E-3 8.340E-3
5.266E-2
 3 221
45 GO:0032944 regulation of mononuclear cell proliferation 9.075E-5 1.202E-3 8.376E-3
5.409E-2
 3 223
46 GO:0033028 myeloid cell apoptotic process 9.540E-5 1.236E-3 8.613E-3
5.686E-2
 2 35
47 GO:0046579 positive regulation of Ras protein signal transduction 1.249E-4 1.584E-3 1.104E-2
7.446E-2
 2 40
48 GO:0046006 regulation of activated T cell proliferation 1.514E-4 1.841E-3 1.283E-2
9.023E-2
 2 44
49 GO:0017145 stem cell division 1.514E-4 1.841E-3 1.283E-2
9.023E-2
 2 44
50 GO:0051057 positive regulation of small GTPase mediated signal transduction 1.656E-4 1.973E-3 1.375E-2
9.867E-2
 2 46
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 8 input genes in category / 9 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0072536 interleukin-23 receptor complex 8.393E-4 7.553E-3 2.137E-2 7.553E-3 1 2

4: Human Phenotype [Display Chart] 5 input genes in category / 783 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004420 Arterial thrombosis 4.790E-5 2.070E-2
1.499E-1
 3.751E-2 3 81
2 HP:0004414 Abnormality of the pulmonary artery 1.082E-4 2.070E-2
1.499E-1
8.471E-2
 4 327
3 HP:0002321 Vertigo 1.200E-4 2.070E-2
1.499E-1
9.400E-2
 3 110
4 HP:0001063 Acrocyanosis 1.533E-4 2.070E-2
1.499E-1
1.200E-1
 2 19
5 HP:0003401 Paresthesia 1.717E-4 2.070E-2
1.499E-1
1.345E-1
 3 124
6 HP:0004418 Thrombophlebitis 1.977E-4 2.070E-2
1.499E-1
1.548E-1
 3 130
7 HP:0004936 Venous thrombosis 1.977E-4 2.070E-2
1.499E-1
1.548E-1
 3 130
8 HP:0011365 Patchy hypopigmentation of hair 2.264E-4 2.070E-2
1.499E-1
1.773E-1
 2 23
9 HP:0001751 Vestibular dysfunction 2.465E-4 2.070E-2
1.499E-1
1.930E-1
 3 140
10 HP:0004930 Abnormality of the pulmonary vasculature 2.644E-4 2.070E-2
1.499E-1
2.070E-1
 4 410
11 HP:0004950 Peripheral arterial stenosis 3.624E-4 2.580E-2
1.868E-1
2.837E-1
 2 29
12 HP:0004331 Decreased skull ossification 4.705E-4 2.942E-2
2.131E-1
3.684E-1
 2 33
13 HP:0002637 Cerebral ischemia 5.635E-4 2.942E-2
2.131E-1
4.413E-1
 3 185
14 HP:0000360 Tinnitus 5.924E-4 2.942E-2
2.131E-1
4.639E-1
 2 37
15 HP:0005305 Cerebral venous thrombosis 6.251E-4 2.942E-2
2.131E-1
4.894E-1
 2 38
16 HP:0003540 Impaired platelet aggregation 6.929E-4 2.942E-2
2.131E-1
5.426E-1
 2 40
17 HP:0030402 Abnormal platelet aggregation 6.929E-4 2.942E-2
2.131E-1
5.426E-1
 2 40
18 HP:0002863 Myelodysplasia 7.521E-4 2.942E-2
2.131E-1
5.889E-1
 3 204
19 HP:0100749 Chest pain 8.659E-4 2.942E-2
2.131E-1
6.780E-1
 3 214
20 HP:0009145 Abnormal cerebral artery morphology 8.779E-4 2.942E-2
2.131E-1
6.874E-1
 3 215
21 HP:0002216 Premature graying of hair 9.171E-4 2.942E-2
2.131E-1
7.181E-1
 2 46
22 HP:0001907 Thromboembolism 1.030E-3 2.942E-2
2.131E-1
8.064E-1
 3 227
23 HP:0001977 Abnormal thrombosis 1.030E-3 2.942E-2
2.131E-1
8.064E-1
 3 227
24 HP:0001045 Vitiligo 1.041E-3 2.942E-2
2.131E-1
8.149E-1
 2 49
25 HP:0003252 Anteriorly displaced genitalia 1.062E-3 2.942E-2
2.131E-1
8.317E-1
 1 1
26 HP:0008817 Aplastic pubic bones 1.062E-3 2.942E-2
2.131E-1
8.317E-1
 1 1
27 HP:0010769 Pilonidal sinus 1.062E-3 2.942E-2
2.131E-1
8.317E-1
 1 1
28 HP:0002092 Pulmonary arterial hypertension 1.098E-3 2.942E-2
2.131E-1
8.597E-1
 3 232
29 HP:0004890 Elevated pulmonary artery pressure 1.098E-3 2.942E-2
2.131E-1
8.597E-1
 3 232
30 HP:0025323 Abnormal arterial physiology 1.127E-3 2.942E-2
2.131E-1
8.827E-1
 2 51
31 HP:0011869 Abnormal platelet function 1.408E-3 3.555E-2
2.574E-1
1.000E0
 2 57
32 HP:0100545 Arterial stenosis 1.551E-3 3.679E-2
2.664E-1
1.000E0
 3 261
33 HP:0005114 Abnormalities of the peripheral arteries 1.551E-3 3.679E-2
2.664E-1
1.000E0
 3 261
34 HP:0002625 Deep venous thrombosis 1.664E-3 3.833E-2
2.775E-1
1.000E0
 2 62
35 HP:0002639 Budd-Chiari syndrome 1.828E-3 4.090E-2
2.962E-1
1.000E0
 2 65
36 HP:0030846 Abnormality of venous physiology 1.942E-3 4.109E-2
2.975E-1
1.000E0
 2 67
37 HP:0005506 Chronic myelogenous leukemia 1.942E-3 4.109E-2
2.975E-1
1.000E0
 2 67
38 HP:0400004 Long ear 2.124E-3 4.208E-2
3.047E-1
1.000E0
 1 2
39 HP:0007505 Progressive hyperpigmentation 2.124E-3 4.208E-2
3.047E-1
1.000E0
 1 2
40 HP:0002624 Abnormal venous morphology 2.173E-3 4.208E-2
3.047E-1
1.000E0
 3 293
41 HP:0003063 Abnormality of the humerus 2.261E-3 4.208E-2
3.047E-1
1.000E0
 3 297
42 HP:0001454 Abnormality of the upper arm 2.328E-3 4.208E-2
3.047E-1
1.000E0
 3 300
43 HP:0030875 Abnormality of pulmonary circulation 2.328E-3 4.208E-2
3.047E-1
1.000E0
 3 300
44 HP:0011358 Generalized hypopigmentation of hair 2.365E-3 4.208E-2
3.047E-1
1.000E0
 2 74
45 HP:0002703 Abnormality of skull ossification 2.493E-3 4.338E-2
3.141E-1
1.000E0
 2 76
46 HP:0000961 Cyanosis 2.625E-3 4.468E-2
3.235E-1
1.000E0
 2 78
Show 41 more annotations

5: Mouse Phenotype [Display Chart] 6 input genes in category / 408 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0013662 decreased myeloid cell number 3.612E-5 1.131E-2
7.454E-2
 1.474E-2 4 416
2 MP:0000245 abnormal erythropoiesis 5.545E-5 1.131E-2
7.454E-2
 2.262E-2 3 148
3 MP:0008255 decreased megakaryocyte cell number 1.051E-4 1.194E-2
7.870E-2
 4.287E-2 2 28
4 MP:0000208 decreased hematocrit 1.380E-4 1.194E-2
7.870E-2
5.632E-2
 3 201
5 MP:0002874 decreased hemoglobin content 1.464E-4 1.194E-2
7.870E-2
5.971E-2
 3 205
6 MP:0002875 decreased erythrocyte cell number 2.393E-4 1.628E-2
1.072E-1
9.765E-2
 3 242
7 MP:0002596 abnormal hematocrit 3.529E-4 1.909E-2
1.258E-1
1.440E-1
 3 276
8 MP:0005563 abnormal hemoglobin content 4.001E-4 1.909E-2
1.258E-1
1.633E-1
 3 288
9 MP:0001586 abnormal erythrocyte cell number 5.762E-4 1.909E-2
1.258E-1
2.351E-1
 3 326
10 MP:0008857 myelencephalic blebs 5.794E-4 1.909E-2
1.258E-1
2.364E-1
 1 1
11 MP:0002320 hyperventilation 5.794E-4 1.909E-2
1.258E-1
2.364E-1
 1 1
12 MP:0011090 perinatal lethality, incomplete penetrance 6.079E-4 1.909E-2
1.258E-1
2.480E-1
 3 332
13 MP:0005671 abnormal response to transplant 6.084E-4 1.909E-2
1.258E-1
2.482E-1
 2 67
14 MP:0002599 increased mean platelet volume 7.419E-4 2.162E-2
1.425E-1
3.027E-1
 2 74
15 MP:0001577 anemia 8.753E-4 2.381E-2
1.569E-1
3.571E-1
 3 376
16 MP:0009934 abnormal hind foot hair pigmentation 1.159E-3 2.954E-2
1.947E-1
4.727E-1
 1 2
17 MP:0002586 abnormal platelet volume 1.544E-3 3.503E-2
2.308E-1
6.301E-1
 2 107
18 MP:0000603 pale liver 1.602E-3 3.503E-2
2.308E-1
6.537E-1
 2 109
19 MP:0002417 abnormal megakaryocyte morphology 1.631E-3 3.503E-2
2.308E-1
6.656E-1
 2 110
20 MP:0001588 abnormal hemoglobin 1.837E-3 3.594E-2
2.368E-1
7.494E-1
 3 485
21 MP:0013660 abnormal bone marrow hematopoietic cell morphology 1.906E-3 3.594E-2
2.368E-1
7.777E-1
 2 119
22 MP:0008801 abnormal erythroid progenitor cell morphology 1.938E-3 3.594E-2
2.368E-1
7.907E-1
 2 120
23 MP:0009071 short oviduct 2.316E-3 3.780E-2
2.491E-1
9.449E-1
 1 4
24 MP:0008985 hemimelia 2.316E-3 3.780E-2
2.491E-1
9.449E-1
 1 4
25 MP:0008253 absent megakaryocytes 2.316E-3 3.780E-2
2.491E-1
9.449E-1
 1 4
26 MP:0006410 abnormal common myeloid progenitor cell morphology 2.627E-3 4.072E-2
2.683E-1
1.000E0
 2 140
27 MP:0000472 abnormal stomach non-glandular epithelium morphology 2.894E-3 4.072E-2
2.683E-1
1.000E0
 1 5
28 MP:0000370 head blaze 2.894E-3 4.072E-2
2.683E-1
1.000E0
 1 5
29 MP:0003282 gastric ulcer 2.894E-3 4.072E-2
2.683E-1
1.000E0
 1 5
30 MP:0000333 decreased bone marrow cell number 3.010E-3 4.093E-2
2.697E-1
1.000E0
 2 150
31 MP:0003301 peptic ulcer 3.472E-3 4.167E-2
2.746E-1
1.000E0
 1 6
32 MP:0009933 abnormal tail hair pigmentation 3.472E-3 4.167E-2
2.746E-1
1.000E0
 1 6
33 MP:0002319 hyperoxia 3.472E-3 4.167E-2
2.746E-1
1.000E0
 1 6
34 MP:0011568 decreased foot pigmentation 3.472E-3 4.167E-2
2.746E-1
1.000E0
 1 6
35 MP:0008237 abnormal ventral coat pigmentation 4.050E-3 4.223E-2
2.783E-1
1.000E0
 1 7
36 MP:0004478 increased testicular teratoma incidence 4.050E-3 4.223E-2
2.783E-1
1.000E0
 1 7
37 MP:0011610 abnormal primordial germ cell apoptosis 4.628E-3 4.223E-2
2.783E-1
1.000E0
 1 8
38 MP:0008712 decreased interleukin-9 secretion 4.628E-3 4.223E-2
2.783E-1
1.000E0
 1 8
39 MP:0011902 increased hematopoietic stem cell proliferation 4.628E-3 4.223E-2
2.783E-1
1.000E0
 1 8
40 MP:0010784 abnormal forestomach morphology 4.628E-3 4.223E-2
2.783E-1
1.000E0
 1 8
41 MP:0011243 decreased fetal derived definitive erythrocyte cell number 5.205E-3 4.223E-2
2.783E-1
1.000E0
 1 9
42 MP:0004032 abnormal interventricular groove morphology 5.205E-3 4.223E-2
2.783E-1
1.000E0
 1 9
43 MP:0005575 increased pulmonary ventilation 5.205E-3 4.223E-2
2.783E-1
1.000E0
 1 9
44 MP:0001189 absent skin pigmentation 5.205E-3 4.223E-2
2.783E-1
1.000E0
 1 9
45 MP:0011188 increased erythrocyte protoporphyrin level 5.205E-3 4.223E-2
2.783E-1
1.000E0
 1 9
46 MP:0005175 non-pigmented tail tip 5.205E-3 4.223E-2
2.783E-1
1.000E0
 1 9
47 MP:0009669 abnormal postimplantation uterine environment 5.782E-3 4.223E-2
2.783E-1
1.000E0
 1 10
48 MP:0008257 thin myometrium 5.782E-3 4.223E-2
2.783E-1
1.000E0
 1 10
49 MP:0009097 absent endometrial glands 5.782E-3 4.223E-2
2.783E-1
1.000E0
 1 10
50 MP:0009070 small oviduct 5.782E-3 4.223E-2
2.783E-1
1.000E0
 1 10
Show 45 more annotations

6: Domain [Display Chart] 8 input genes in category / 30 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1.20.1250.10 - Gene3D 6.135E-12 1.020E-10 4.075E-10 1.840E-10 5 50
2 IPR012351 4 helix cytokine core InterPro 6.801E-12 1.020E-10 4.075E-10 2.040E-10 5 51
3 IPR009079 4 helix cytokine-like core InterPro 4.649E-11 4.649E-10 1.857E-9 1.395E-9 5 74
4 IPR001323 EPO TPO InterPro 1.596E-7 6.838E-7 2.732E-6 4.787E-6 2 2
5 PF00758 EPO TPO Pfam 1.596E-7 6.838E-7 2.732E-6 4.787E-6 2 2
6 PS00817 EPO TPO PROSITE 1.596E-7 6.838E-7 2.732E-6 4.787E-6 2 2
7 IPR019767 EPO/TPO CS InterPro 1.596E-7 6.838E-7 2.732E-6 4.787E-6 2 2
8 IPR003978 Thrombopoeitin InterPro 4.270E-4 8.006E-4 3.199E-3 1.281E-2 1 1
9 PF02404 SCF Pfam 4.270E-4 8.006E-4 3.199E-3 1.281E-2 1 1
10 IPR020438 IL-11 InterPro 4.270E-4 8.006E-4 3.199E-3 1.281E-2 1 1
11 IPR003452 SCF InterPro 4.270E-4 8.006E-4 3.199E-3 1.281E-2 1 1
12 PF07400 IL11 Pfam 4.270E-4 8.006E-4 3.199E-3 1.281E-2 1 1
13 PF02059 IL3 Pfam 4.270E-4 8.006E-4 3.199E-3 1.281E-2 1 1
14 IPR003013 Erythroptn InterPro 4.270E-4 8.006E-4 3.199E-3 1.281E-2 1 1
15 IPR002183 IL-3 InterPro 4.270E-4 8.006E-4 3.199E-3 1.281E-2 1 1
16 IPR020412 IL-11 mml InterPro 4.270E-4 8.006E-4 3.199E-3 1.281E-2 1 1
17 IPR013300 Wnt7 InterPro 8.539E-4 1.507E-3 6.020E-3 2.562E-2 1 2
18 IPR003528 Long hematopoietin rcpt CS InterPro 1.707E-3 2.695E-3 1.077E-2
5.121E-2
 1 4
19 PS01352 HEMATOPO REC L F1 PROSITE 1.707E-3 2.695E-3 1.077E-2
5.121E-2
 1 4
20 PF00041 fn3 Pfam 2.011E-3 2.909E-3 1.162E-2
6.032E-2
 2 162
21 PF09067 EpoR lig-bind Pfam 2.133E-3 2.909E-3 1.162E-2
6.400E-2
 1 5
22 IPR015152 Growth/epo recpt lig-bind InterPro 2.133E-3 2.909E-3 1.162E-2
6.400E-2
 1 5
23 SM00060 FN3 SMART 2.611E-3 3.406E-3 1.361E-2
7.834E-2
 2 185
24 PS50853 FN3 PROSITE 3.014E-3 3.767E-3 1.505E-2
9.041E-2
 2 199
25 IPR003961 FN3 dom InterPro 3.318E-3 3.981E-3 1.591E-2
9.954E-2
 2 209
26 IPR018161 Wnt CS InterPro 8.086E-3 8.086E-3 3.230E-2
2.426E-1
 1 19
27 PF00110 wnt Pfam 8.086E-3 8.086E-3 3.230E-2
2.426E-1
 1 19
28 PS00246 WNT1 PROSITE 8.086E-3 8.086E-3 3.230E-2
2.426E-1
 1 19
29 SM00097 WNT1 SMART 8.086E-3 8.086E-3 3.230E-2
2.426E-1
 1 19
30 IPR005817 Wnt InterPro 8.086E-3 8.086E-3 3.230E-2
2.426E-1
 1 19
Show 25 more annotations

7: Pathway [Display Chart] 8 input genes in category / 123 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83051 Cytokine-cytokine receptor interaction BioSystems: KEGG 1.641E-11 2.018E-9 1.088E-8 2.018E-9 7 270
2 M9367 Erythrocyte Differentiation Pathway MSigDB C2 BIOCARTA (v6.0) 9.522E-11 3.953E-9 2.132E-8 1.171E-8 4 15
3 83077 Jak-STAT signaling pathway BioSystems: KEGG 9.641E-11 3.953E-9 2.132E-8 1.186E-8 6 156
4 83078 Hematopoietic cell lineage BioSystems: KEGG 1.422E-9 4.374E-8 2.359E-7 1.750E-7 5 97
5 M5883 Genes encoding secreted soluble factors MSigDB C2 BIOCARTA (v6.0) 1.139E-8 2.802E-7 1.511E-6 1.401E-6 6 344
6 M5298 Regulation of hematopoiesis by cytokines MSigDB C2 BIOCARTA (v6.0) 7.895E-8 1.619E-6 8.730E-6 9.711E-6 3 15
7 M19422 IL 17 Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 4.890E-5 8.593E-4 4.635E-3 6.015E-3 2 17
8 M11520 TPO Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 9.902E-5 1.522E-3 8.211E-3 1.218E-2 2 24
9 M85 Regulation of BAD phosphorylation MSigDB C2 BIOCARTA (v6.0) 1.165E-4 1.593E-3 8.589E-3 1.433E-2 2 26
10 M6910 Cytokines and Inflammatory Response MSigDB C2 BIOCARTA (v6.0) 1.454E-4 1.789E-3 9.647E-3 1.789E-2 2 29
11 1269358 Platelet Aggregation (Plug Formation) BioSystems: REACTOME 2.511E-4 2.808E-3 1.514E-2 3.088E-2 2 38
12 138068 Signaling events mediated by Stem cell factor receptor (c-Kit) BioSystems: Pathway Interaction Database 4.715E-4 4.832E-3 2.606E-2
5.799E-2
 2 52
13 1269350 Platelet activation, signaling and aggregation BioSystems: REACTOME 5.918E-4 5.599E-3 3.020E-2
7.279E-2
 3 282
14 692234 PI3K-Akt signaling pathway BioSystems: KEGG 1.038E-3 9.123E-3 4.920E-2
1.277E-1
 3 342
15 83092 Melanogenesis BioSystems: KEGG 1.767E-3 1.449E-2
7.817E-2
2.174E-1
 2 101
16 M6917 Erythropoietin mediated neuroprotection through NF-kB MSigDB C2 BIOCARTA (v6.0) 7.048E-3 3.618E-2
1.952E-1
8.670E-1
 1 11
17 1270419 Regulation of gene expression by Hypoxia-inducible Factor BioSystems: REACTOME 7.687E-3 3.618E-2
1.952E-1
9.455E-1
 1 12
18 M17681 IL 3 signaling pathway MSigDB C2 BIOCARTA (v6.0) 9.601E-3 3.618E-2
1.952E-1
1.000E0
 1 15
19 M13324 Hypoxia-Inducible Factor in the Cardiovascular System MSigDB C2 BIOCARTA (v6.0) 9.601E-3 3.618E-2
1.952E-1
1.000E0
 1 15
20 1269440 SOS-mediated signalling BioSystems: REACTOME 1.022E-2 3.618E-2
1.952E-1
1.000E0
 2 248
21 1269383 SHC1 events in EGFR signaling BioSystems: REACTOME 1.022E-2 3.618E-2
1.952E-1
1.000E0
 2 248
22 1269382 GRB2 events in EGFR signaling BioSystems: REACTOME 1.022E-2 3.618E-2
1.952E-1
1.000E0
 2 248
23 1269285 RAF/MAP kinase cascade BioSystems: REACTOME 1.022E-2 3.618E-2
1.952E-1
1.000E0
 2 248
24 1269488 Regulation of KIT signaling BioSystems: REACTOME 1.024E-2 3.618E-2
1.952E-1
1.000E0
 1 16
25 1269471 ARMS-mediated activation BioSystems: REACTOME 1.054E-2 3.618E-2
1.952E-1
1.000E0
 2 252
26 1269468 Signalling to p38 via RIT and RIN BioSystems: REACTOME 1.054E-2 3.618E-2
1.952E-1
1.000E0
 2 252
27 1269470 Frs2-mediated activation BioSystems: REACTOME 1.062E-2 3.618E-2
1.952E-1
1.000E0
 2 253
28 1269502 MAPK1/MAPK3 signaling BioSystems: REACTOME 1.070E-2 3.618E-2
1.952E-1
1.000E0
 2 254
29 1269469 Prolonged ERK activation events BioSystems: REACTOME 1.079E-2 3.618E-2
1.952E-1
1.000E0
 2 255
30 1269632 Signaling by Leptin BioSystems: REACTOME 1.087E-2 3.618E-2
1.952E-1
1.000E0
 2 256
31 1269322 Interleukin receptor SHC signaling BioSystems: REACTOME 1.103E-2 3.618E-2
1.952E-1
1.000E0
 2 258
32 1269465 Signalling to RAS BioSystems: REACTOME 1.111E-2 3.618E-2
1.952E-1
1.000E0
 2 259
33 1269485 VEGFR2 mediated cell proliferation BioSystems: REACTOME 1.128E-2 3.618E-2
1.952E-1
1.000E0
 2 261
34 M6682 CDK Regulation of DNA Replication MSigDB C2 BIOCARTA (v6.0) 1.151E-2 3.618E-2
1.952E-1
1.000E0
 1 18
35 1269321 Interleukin-2 signaling BioSystems: REACTOME 1.161E-2 3.618E-2
1.952E-1
1.000E0
 2 265
36 1269464 Signalling to ERKs BioSystems: REACTOME 1.170E-2 3.618E-2
1.952E-1
1.000E0
 2 266
37 M12836 EPO Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.215E-2 3.618E-2
1.952E-1
1.000E0
 1 19
38 1427866 RET signaling BioSystems: REACTOME 1.229E-2 3.618E-2
1.952E-1
1.000E0
 2 273
39 1269299 FCERI mediated MAPK activation BioSystems: REACTOME 1.238E-2 3.618E-2
1.952E-1
1.000E0
 2 274
40 1269323 Interleukin-3, 5 and GM-CSF signaling BioSystems: REACTOME 1.238E-2 3.618E-2
1.952E-1
1.000E0
 2 274
41 1339143 IL-6-type cytokine receptor ligand interactions BioSystems: REACTOME 1.278E-2 3.618E-2
1.952E-1
1.000E0
 1 20
42 1270312 NCAM signaling for neurite out-growth BioSystems: REACTOME 1.282E-2 3.618E-2
1.952E-1
1.000E0
 2 279
43 M17406 Cytokine Network MSigDB C2 BIOCARTA (v6.0) 1.342E-2 3.618E-2
1.952E-1
1.000E0
 1 21
44 M9177 Dendritic cells in regulating TH1 and TH2 Development MSigDB C2 BIOCARTA (v6.0) 1.405E-2 3.618E-2
1.952E-1
1.000E0
 1 22
45 137971 Paxillin-independent events mediated by a4b1 and a4b7 BioSystems: Pathway Interaction Database 1.405E-2 3.618E-2
1.952E-1
1.000E0
 1 22
46 1269501 MAPK family signaling cascades BioSystems: REACTOME 1.407E-2 3.618E-2
1.952E-1
1.000E0
 2 293
47 1269431 IRS-mediated signalling BioSystems: REACTOME 1.453E-2 3.618E-2
1.952E-1
1.000E0
 2 298
48 1269429 Insulin receptor signalling cascade BioSystems: REACTOME 1.481E-2 3.618E-2
1.952E-1
1.000E0
 2 301
49 1269618 IGF1R signaling cascade BioSystems: REACTOME 1.491E-2 3.618E-2
1.952E-1
1.000E0
 2 302
50 1269620 IRS-related events triggered by IGF1R BioSystems: REACTOME 1.491E-2 3.618E-2
1.952E-1
1.000E0
 2 302
Show 45 more annotations

8: Pubmed [Display Chart] 8 input genes in category / 2737 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 21664343 Hepatoblasts comprise a niche for fetal liver erythropoiesis through cytokine production. Pubmed 1.657E-13 4.536E-10 3.852E-9 4.536E-10 4 10
2 9722506 Insulin-like growth factor-I augments erythropoietin-induced proliferation through enhanced tyrosine phosphorylation of STAT5. Pubmed 6.030E-11 8.252E-8 7.008E-7 1.650E-7 3 5
3 7690439 Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. Pubmed 1.206E-10 1.100E-7 9.343E-7 3.301E-7 3 6
4 10943842 Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Pubmed 9.271E-9 3.090E-6 2.624E-5 2.538E-5 3 22
5 8202154 Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
6 15642952 A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
7 15307100 Association of single nucleotide polymorphisms in the thrombopoietin-receptor gene, but not the thrombopoietin gene, with differences in platelet count. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
8 16051888 Thrombopoietin gene transfer-mediated enhancement of angiogenic responses to acute ischemia. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
9 7540890 Accelerated cell-cycling of hematopoietic progenitor cells by growth factors. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
10 8639822 Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
11 9766811 Native thrombopoietin: structure and function. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
12 12393382 Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
13 12005542 Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice: interactive effect with thrombopoietin. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
14 17942981 Synergistic effect of cytokines EPO, IL-3 and SCF on the proliferation, differentiation and apoptosis of erythroid progenitor cells. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
15 16759877 Relationship of thrombopoietin and interleukin-11 levels to thrombocytopenia associated with dengue disease. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
16 9345025 Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietin. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
17 17969148 Synergy between erythropoietin and stem cell factor during erythropoiesis can be quantitatively described without co-signaling effects. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
18 9474742 Hematopoietic deficiencies in c-mpl and TPO knockout mice. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
19 11961237 Human plasma thrombopoietin levels are regulated by binding to platelet thrombopoietin receptors in vivo. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
20 28456746 Genetically engineered mesenchymal stromal cells produce IL-3 and TPO to further improve human scaffold-based xenograft models. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
21 15647951 Thrombocytosis in preterm infants: a possible involvement of thrombopoietin receptor gene expression. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
22 16454716 Thrombocytopenia in HIV infection: impairment of platelet formation and loss correlates with increased c-Mpl and ligand thrombopoietin expression. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
23 15781331 Thrombopoietin alone or in the presence of stem cell factor supports the growth of KIT(CD117)low/ MPL(CD110)+ human mast cells from hematopoietic progenitor cells. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
24 30005133 JAK2V617F Megakaryocytes Promote Hematopoietic Stem/Progenitor Cell Expansion in Mice Through Thrombopoietin/MPL Signaling. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
25 8704234 Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
26 26912146 H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
27 29217821 IL-11 promotes the treatment efficacy of hematopoietic stem cell transplant therapy in aplastic anemia model mice through a NF-κB/microRNA-204/thrombopoietin regulatory axis. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
28 10582337 Thrombopoietin and the c-Mpl receptor: insights from gene targeting. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
29 14995067 Modulation of human c-mpl gene expression by thrombopoietin through protein kinase C. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
30 17634189 Dual role of Mpl receptor during the establishment of definitive hematopoiesis. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
31 29313460 Thrombopoietin and its receptor expression in pediatric patients with chronic immune thrombocytopenia. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
32 17347409 Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
33 17637498 Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
34 1375116 Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. Pubmed 3.839E-8 3.090E-6 2.624E-5 1.051E-4 2 2
35 20529857 Identification of the residues in the extracellular domain of thrombopoietin receptor involved in the binding of thrombopoietin and a nuclear distribution protein (human NUDC). Pubmed 1.152E-7 6.852E-6 5.819E-5 3.152E-4 2 3
36 9531584 Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production. Pubmed 1.152E-7 6.852E-6 5.819E-5 3.152E-4 2 3
37 9558377 Interactions of erythropoietin, granulocyte colony-stimulating factor, stem cell factor, and interleukin-11 on murine hematopoiesis during simultaneous administration. Pubmed 1.152E-7 6.852E-6 5.819E-5 3.152E-4 2 3
38 21149592 Thrombopoietin contributes to neuronal damage in experimental bacterial meningitis. Pubmed 1.152E-7 6.852E-6 5.819E-5 3.152E-4 2 3
39 21540074 Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells. Pubmed 1.152E-7 6.852E-6 5.819E-5 3.152E-4 2 3
40 14628073 NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration. Pubmed 1.152E-7 6.852E-6 5.819E-5 3.152E-4 2 3
41 12002675 Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells. Pubmed 1.152E-7 6.852E-6 5.819E-5 3.152E-4 2 3
42 12829027 Stem cell factor enhances erythropoietin-mediated transactivation of signal transducer and activator of transcription 5 (STAT5) via the PKA/CREB pathway. Pubmed 1.152E-7 6.852E-6 5.819E-5 3.152E-4 2 3
43 15988318 Association between nucleated red blood cells in blood and the levels of erythropoietin, interleukin 3, interleukin 6, and interleukin 12p70. Pubmed 1.152E-7 6.852E-6 5.819E-5 3.152E-4 2 3
44 18928604 [Expression of hematopoietic cytokines EPO, SCF and GM-CSF in bone marrow cells of patients with chronic aplastic anemia]. Pubmed 1.152E-7 6.852E-6 5.819E-5 3.152E-4 2 3
45 15337790 Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. Pubmed 1.152E-7 6.852E-6 5.819E-5 3.152E-4 2 3
46 25339357 The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm. Pubmed 1.152E-7 6.852E-6 5.819E-5 3.152E-4 2 3
47 15504551 Hepatocyte growth factor plays roles in the induction and autocrine maintenance of bone marrow stromal cell IL-11, SDF-1 alpha, and stem cell factor. Pubmed 2.303E-7 1.126E-5 9.558E-5 6.303E-4 2 4
48 20667107 Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system. Pubmed 2.303E-7 1.126E-5 9.558E-5 6.303E-4 2 4
49 25298035 Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. Pubmed 2.303E-7 1.126E-5 9.558E-5 6.303E-4 2 4
50 8943846 Soluble thrombopoietin receptor (Mpl) and granulocyte colony-stimulating factor receptor directly stimulate proliferation of primitive hematopoietic progenitors of mice in synergy with steel factor or the ligand for Flt3/Flk2. Pubmed 2.303E-7 1.126E-5 9.558E-5 6.303E-4 2 4
Show 45 more annotations

9: Interaction [Display Chart] 8 input genes in category / 80 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:THPO THPO interactions 1.786E-6 1.429E-4 7.094E-4 1.429E-4 2 5
2 int:MPL MPL interactions 1.177E-5 4.707E-4 2.337E-3 9.414E-4 2 12
3 int:PIK3CD PIK3CD interactions 3.044E-5 8.117E-4 4.031E-3 2.435E-3 2 19
4 int:EPOR EPOR interactions 1.912E-4 3.824E-3 1.899E-2 1.530E-2 2 47
5 int:IL11RA IL11RA interactions 9.036E-4 1.446E-2
7.179E-2
7.229E-2
 1 2
6 int:PIK3CA PIK3CA interactions 1.242E-3 1.638E-2
8.135E-2
9.938E-2
 2 120
7 int:JAK2 JAK2 interactions 1.434E-3 1.638E-2
8.135E-2
1.147E-1
 2 129
8 int:FLT3LG FLT3LG interactions 1.807E-3 1.807E-2
8.970E-2
1.445E-1
 1 4
9 int:IL23R IL23R interactions 2.709E-3 2.106E-2
1.046E-1
2.167E-1
 1 6
10 int:IL11 IL11 interactions 2.709E-3 2.106E-2
1.046E-1
2.167E-1
 1 6
11 int:IL3 IL3 interactions 3.160E-3 2.106E-2
1.046E-1
2.528E-1
 1 7
12 int:FZD9 FZD9 interactions 3.160E-3 2.106E-2
1.046E-1
2.528E-1
 1 7
13 int:IL23A IL23A interactions 3.610E-3 2.222E-2
1.103E-1
2.888E-1
 1 8
14 int:EPO EPO interactions 4.061E-3 2.269E-2
1.127E-1
3.249E-1
 1 9
15 int:PIK3AP1 PIK3AP1 interactions 4.511E-3 2.269E-2
1.127E-1
3.609E-1
 1 10
16 int:PORCN PORCN interactions 4.961E-3 2.269E-2
1.127E-1
3.969E-1
 1 11
17 int:CMA1 CMA1 interactions 4.961E-3 2.269E-2
1.127E-1
3.969E-1
 1 11
18 int:SIM2 SIM2 interactions 5.411E-3 2.269E-2
1.127E-1
4.329E-1
 1 12
19 int:KITLG KITLG interactions 5.861E-3 2.269E-2
1.127E-1
4.689E-1
 1 13
20 int:WNT7B WNT7B interactions 6.310E-3 2.269E-2
1.127E-1
5.048E-1
 1 14
21 int:CSF2 CSF2 interactions 6.760E-3 2.269E-2
1.127E-1
5.408E-1
 1 15
22 int:ATP8B2 ATP8B2 interactions 6.760E-3 2.269E-2
1.127E-1
5.408E-1
 1 15
23 int:IL3RA IL3RA interactions 7.209E-3 2.269E-2
1.127E-1
5.767E-1
 1 16
24 int:FZD5 FZD5 interactions 7.209E-3 2.269E-2
1.127E-1
5.767E-1
 1 16
25 int:CRELD2 CRELD2 interactions 7.209E-3 2.269E-2
1.127E-1
5.767E-1
 1 16
26 int:NPAS1 NPAS1 interactions 7.658E-3 2.269E-2
1.127E-1
6.126E-1
 1 17
27 int:FZD7 FZD7 interactions 7.658E-3 2.269E-2
1.127E-1
6.126E-1
 1 17
28 int:WLS WLS interactions 9.004E-3 2.573E-2
1.277E-1
7.203E-1
 1 20
29 int:IL12RB1 IL12RB1 interactions 9.901E-3 2.613E-2
1.298E-1
7.921E-1
 1 22
30 int:KLHDC10 KLHDC10 interactions 1.035E-2 2.613E-2
1.298E-1
8.279E-1
 1 23
31 int:DKK1 DKK1 interactions 1.080E-2 2.613E-2
1.298E-1
8.637E-1
 1 24
32 int:FUT11 FUT11 interactions 1.080E-2 2.613E-2
1.298E-1
8.637E-1
 1 24
33 int:HIF1A HIF1A interactions 1.146E-2 2.613E-2
1.298E-1
9.165E-1
 2 374
34 int:LOXL2 LOXL2 interactions 1.169E-2 2.613E-2
1.298E-1
9.353E-1
 1 26
35 int:SLC22A18 SLC22A18 interactions 1.259E-2 2.613E-2
1.298E-1
1.000E0
 1 28
36 int:FSTL1 FSTL1 interactions 1.303E-2 2.613E-2
1.298E-1
1.000E0
 1 29
37 int:WNT5A WNT5A interactions 1.303E-2 2.613E-2
1.298E-1
1.000E0
 1 29
38 int:CSF2RB CSF2RB interactions 1.348E-2 2.613E-2
1.298E-1
1.000E0
 1 30
39 int:PIGU PIGU interactions 1.348E-2 2.613E-2
1.298E-1
1.000E0
 1 30
40 int:COL6A1 COL6A1 interactions 1.393E-2 2.613E-2
1.298E-1
1.000E0
 1 31
41 int:ANKRA2 ANKRA2 interactions 1.393E-2 2.613E-2
1.298E-1
1.000E0
 1 31
42 int:APH1A APH1A interactions 1.437E-2 2.613E-2
1.298E-1
1.000E0
 1 32
43 int:C1D C1D interactions 1.437E-2 2.613E-2
1.298E-1
1.000E0
 1 32
44 int:USF2 USF2 interactions 1.437E-2 2.613E-2
1.298E-1
1.000E0
 1 32
45 int:WNT7A WNT7A interactions 1.526E-2 2.714E-2
1.347E-1
1.000E0
 1 34
46 int:CLEC11A CLEC11A interactions 1.705E-2 2.965E-2
1.472E-1
1.000E0
 1 38
47 int:LDLR LDLR interactions 1.838E-2 3.074E-2
1.526E-1
1.000E0
 1 41
48 int:NUMBL NUMBL interactions 1.883E-2 3.074E-2
1.526E-1
1.000E0
 1 42
49 int:NPTX1 NPTX1 interactions 1.883E-2 3.074E-2
1.526E-1
1.000E0
 1 42
50 int:SDF2L1 SDF2L1 interactions 1.927E-2 3.083E-2
1.531E-1
1.000E0
 1 43
Show 45 more annotations

10: Cytoband [Display Chart] 8 input genes in category / 8 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19q13.3-q13.4 19q13.3-q13.4 2.997E-3 1.287E-2 3.498E-2 2.397E-2 1 13
2 3p25 3p25 3.917E-3 1.287E-2 3.498E-2 3.134E-2 1 17
3 3q27 3q27 5.756E-3 1.287E-2 3.498E-2 4.605E-2 1 25
4 1p34 1p34 7.363E-3 1.287E-2 3.498E-2
5.890E-2
 1 32
5 7q22 7q22 8.967E-3 1.287E-2 3.498E-2
7.174E-2
 1 39
6 12q22 12q22 9.654E-3 1.287E-2 3.498E-2
7.723E-2
 1 42
7 1p31.3 1p31.3 1.263E-2 1.443E-2 3.922E-2
1.010E-1
 1 55
8 5q31.1 5q31.1 1.491E-2 1.491E-2 4.051E-2
1.192E-1
 1 65
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 94 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 542 Endogenous ligands genenames.org 4.241E-5 2.441E-4 5.979E-4 2.544E-4 3 237
2 601 Interleukins|PDZ domain containing genenames.org 8.135E-5 2.441E-4 5.979E-4 4.881E-4 2 43
3 1264 Interleukin 6 cytokine family genenames.org 2.307E-3 4.613E-3 1.130E-2 1.384E-2 1 7
4 360 Wnt family genenames.org 6.250E-3 9.375E-3 2.297E-2 3.750E-2 1 19

13: Coexpression [Display Chart] 8 input genes in category / 514 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M17340 NF-kB-driven pro-inflammatory genes that are negatively regulated by glucocorticoids. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.473E-8 2.813E-5 1.919E-4 2.813E-5 3 24
2 20460173-ImmPortCytokines Human Immune Kong10 456genes ImmPort Cytokines GeneSigDB 1.199E-7 3.083E-5 2.102E-4 6.165E-5 5 433
3 M11893 A biomarker of plasma signaling proteins that predicts clinical Alzheimer's diagnosis. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.144E-6 1.395E-3 9.517E-3 4.186E-3 2 13
4 M2839 Genes up-regulated in a panel of epithelial cell lines by TGFB1 [Gene ID=7040]. MSigDB C6: Oncogenic Signatures (v6.0) 3.055E-5 3.926E-3 2.678E-2 1.571E-2 3 192
5 19922785-Table3 Human Leukemia Yang09 42genes GeneSigDB 8.521E-5 7.663E-3
5.227E-2
 4.380E-2 2 41
6 20460173-ImmPortInterleukins Human Immune Kong10 47genes ImmPort Interleukins GeneSigDB 8.945E-5 7.663E-3
5.227E-2
 4.598E-2 2 42
7 19802007-SuppTable2 Human StemCell Novakova10 89genes CommonCytokines GeneSigDB 2.022E-4 1.426E-2
9.725E-2
1.039E-1
 2 63
8 M6752 Genes essential to the development of megakaryocytes, as expressed in normal cells and essential thrombocythemic cells (ET). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.219E-4 1.426E-2
9.725E-2
1.141E-1
 2 66
9 M8174 Genes down-regulated in HEK293 cells at 2h after stimulation by muramyl dipeptide [PubChem=11620162]: over-expressing mutant NOD2 [GeneID=64127] versus control. MSigDB C7: Immunologic Signatures (v6.0) 7.563E-4 4.319E-2
2.946E-1
3.887E-1
 2 122
10 M1876 Cytokines, growth factors, and secreted proteins that show decreased expression on a protein array of samples from aged TERC [GeneID=7012] knockout mice. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.728E-3 4.924E-2
3.358E-1
8.881E-1
 1 5
11 M7930 Genes up-regulated in bone marrow-derived macrophages with STAT6 [GeneID=6778] knockout: control versus treated with IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 1.837E-3 4.924E-2
3.358E-1
9.443E-1
 2 191
12 M9910 Genes down-regulated in dendritic cells: untreated versus 8h after infection of Leishmania major. MSigDB C7: Immunologic Signatures (v6.0) 1.953E-3 4.924E-2
3.358E-1
1.000E0
 2 197
13 M6163 Genes down-regulated in D10.G4.1 T cell line (0.8h): control versus treated with NMU [GeneID=10874]. MSigDB C7: Immunologic Signatures (v6.0) 1.953E-3 4.924E-2
3.358E-1
1.000E0
 2 197
14 M5584 Genes up-regulated in comparison of central memory CD4 [GeneID=920] T cells versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 4.924E-2
3.358E-1
1.000E0
 2 199
15 M5573 Genes up-regulated in comparison of effective memory CD4 [GeneID=920] T cells versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 4.924E-2
3.358E-1
1.000E0
 2 199
16 M3587 Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.924E-2
3.358E-1
1.000E0
 2 200
17 M3612 Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 72 h after stimulation with antigen-B7-1. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.924E-2
3.358E-1
1.000E0
 2 200
18 M8844 Genes up-regulated in NK cells: RAG2 [GeneID=5897] knockout versus RAG2 and ETS1 [GeneID=5897;2113] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.924E-2
3.358E-1
1.000E0
 2 200
19 M9835 Genes down-regulated in at day 0 B cell IRF4-KO versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4intermediate. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.924E-2
3.358E-1
1.000E0
 2 200
20 M8836 Genes up-regulated in hematopoietic stem cells versus multipotent progenitors. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.924E-2
3.358E-1
1.000E0
 2 200
21 M3418 Genes down-regulated in comparison of regulatory T cell (Treg) versus effector T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.924E-2
3.358E-1
1.000E0
 2 200
Show 16 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 520 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 5 input genes in category / 33 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M15983 MODULE 46 Genes in the cancer module 46. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.659E-4 1.868E-2
7.636E-2
 1.868E-2 3 394
2 M10197 MODULE 92 Secreted signaling molecules. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.126E-3 3.507E-2
1.434E-1
7.015E-2
 2 149
3 M13205 MORF IL4 Neighborhood of IL4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.650E-3 4.015E-2
1.641E-1
1.204E-1
 2 196

16: MicroRNA [Display Chart] 8 input genes in category / 202 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-518f:mirSVR highEffct hsa-miR-518f:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.012E-4 2.316E-2
1.364E-1
6.084E-2
 2 239
2 hsa-miR-518c:mirSVR highEffct hsa-miR-518c:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.982E-4 2.316E-2
1.364E-1
8.044E-2
 2 275
3 AATGTGA,MIR-23B:MSigDB AATGTGA,MIR-23B:MSigDB MSigDB 8.211E-4 2.316E-2
1.364E-1
1.659E-1
 2 396
4 AATGTGA,MIR-23A:MSigDB AATGTGA,MIR-23A:MSigDB MSigDB 8.211E-4 2.316E-2
1.364E-1
1.659E-1
 2 396
5 hsa-miR-3186-5p:mirSVR lowEffct hsa-miR-3186-5p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.418E-4 2.316E-2
1.364E-1
1.700E-1
 2 401
6 hsa-miR-631:mirSVR highEffct hsa-miR-631:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.796E-4 2.316E-2
1.364E-1
1.777E-1
 2 410
7 hsa-miR-122*:mirSVR lowEffct hsa-miR-122*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.967E-4 2.316E-2
1.364E-1
1.811E-1
 2 414
8 hsa-miR-4300:mirSVR highEffct hsa-miR-4300:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.488E-4 2.316E-2
1.364E-1
1.917E-1
 2 426
9 hsa-miR-1274b:mirSVR highEffct hsa-miR-1274b:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.119E-3 2.316E-2
1.364E-1
2.260E-1
 2 463
10 hsa-miR-3199:mirSVR highEffct hsa-miR-3199:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.236E-3 2.316E-2
1.364E-1
2.497E-1
 2 487
11 hsa-miR-769-3p:mirSVR highEffct hsa-miR-769-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.261E-3 2.316E-2
1.364E-1
2.548E-1
 2 492
12 hsa-miR-3684:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.102E-3 3.438E-2
2.024E-1
4.247E-1
 1 19
13 hsa-miR-572:Functional MTI Functional MTI miRTarbase 2.213E-3 3.438E-2
2.024E-1
4.470E-1
 1 20
14 hsa-miR-708-3p:Functional MTI Functional MTI miRTarbase 4.421E-3 4.977E-2
2.930E-1
8.931E-1
 1 40
15 hsa-miR-3661:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.414E-3 4.977E-2
2.930E-1
1.000E0
 1 49
16 hsa-miR-631:Functional MTI Functional MTI miRTarbase 5.634E-3 4.977E-2
2.930E-1
1.000E0
 1 51
17 hsa-miR-4777-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.744E-3 4.977E-2
2.930E-1
1.000E0
 1 52
18 GCAAGGA,MIR-502:MSigDB GCAAGGA,MIR-502:MSigDB MSigDB 7.066E-3 4.977E-2
2.930E-1
1.000E0
 1 64
19 hsa-miR-155-3p:Functional MTI Functional MTI miRTarbase 7.506E-3 4.977E-2
2.930E-1
1.000E0
 1 68
20 AAGGGAT,MIR-188:MSigDB AAGGGAT,MIR-188:MSigDB MSigDB 7.836E-3 4.977E-2
2.930E-1
1.000E0
 1 71
21 hsa-miR-452-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.276E-3 4.977E-2
2.930E-1
1.000E0
 1 75
22 hsa-miR-29b-1-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.276E-3 4.977E-2
2.930E-1
1.000E0
 1 75
23 hsa-miR-151a-5p:Functional MTI Functional MTI miRTarbase 8.716E-3 4.977E-2
2.930E-1
1.000E0
 1 79
24 hsa-miR-222-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.155E-3 4.977E-2
2.930E-1
1.000E0
 1 83
25 hsa-miR-135b-5p:Functional MTI Functional MTI miRTarbase 9.155E-3 4.977E-2
2.930E-1
1.000E0
 1 83
26 hsa-miR-6854-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.155E-3 4.977E-2
2.930E-1
1.000E0
 1 83
27 hsa-miR-379-5p:Functional MTI Functional MTI miRTarbase 9.375E-3 4.977E-2
2.930E-1
1.000E0
 1 85
28 hsa-miR-886-3p:mirSVR highEffct hsa-miR-886-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.375E-3 4.977E-2
2.930E-1
1.000E0
 1 85
29 hsa-miR-668:PITA hsa-miR-668:PITA TOP PITA 9.485E-3 4.977E-2
2.930E-1
1.000E0
 1 86
30 TCTGATA,MIR-361:MSigDB TCTGATA,MIR-361:MSigDB MSigDB 9.594E-3 4.977E-2
2.930E-1
1.000E0
 1 87
31 hsa-miR-664a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.003E-2 4.977E-2
2.930E-1
1.000E0
 1 91
32 hsa-miR-1281:mirSVR highEffct hsa-miR-1281:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.014E-2 4.977E-2
2.930E-1
1.000E0
 1 92
33 hsa-miR-296-3p:PITA hsa-miR-296-3p:PITA TOP PITA 1.025E-2 4.977E-2
2.930E-1
1.000E0
 1 93
34 hsa-miR-4263:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.036E-2 4.977E-2
2.930E-1
1.000E0
 1 94
35 hsa-miR-135a-5p:Functional MTI Functional MTI miRTarbase 1.036E-2 4.977E-2
2.930E-1
1.000E0
 1 94
36 hsa-miR-4799-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.036E-2 4.977E-2
2.930E-1
1.000E0
 1 94
37 ATTACAT,MIR-380-3P:MSigDB ATTACAT,MIR-380-3P:MSigDB MSigDB 1.091E-2 4.977E-2
2.930E-1
1.000E0
 1 99
38 hsa-miR-483-3p.1:TargetScan hsa-miR-483-3p.1 TargetScan 1.091E-2 4.977E-2
2.930E-1
1.000E0
 1 99
39 hsa-miR-3131:mirSVR highEffct hsa-miR-3131:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.102E-2 4.977E-2
2.930E-1
1.000E0
 1 100
40 hsa-miR-16-1-3p:Functional MTI Functional MTI miRTarbase 1.102E-2 4.977E-2
2.930E-1
1.000E0
 1 100
41 hsa-miR-621:PITA hsa-miR-621:PITA TOP PITA 1.113E-2 4.977E-2
2.930E-1
1.000E0
 1 101
42 hsa-miR-576-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.113E-2 4.977E-2
2.930E-1
1.000E0
 1 101
43 hsa-miR-4285:mirSVR lowEffct hsa-miR-4285:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.124E-2 4.977E-2
2.930E-1
1.000E0
 1 102
44 hsa-miR-345:PITA hsa-miR-345:PITA TOP PITA 1.124E-2 4.977E-2
2.930E-1
1.000E0
 1 102
45 hsa-miR-28-5p:Functional MTI Functional MTI miRTarbase 1.157E-2 4.977E-2
2.930E-1
1.000E0
 1 105
46 hsa-miR-1308:PITA hsa-miR-1308:PITA TOP PITA 1.157E-2 4.977E-2
2.930E-1
1.000E0
 1 105
47 hsa-miR-5093:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.299E-2 4.977E-2
2.930E-1
1.000E0
 1 118
48 hsa-miR-29b-2-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.310E-2 4.977E-2
2.930E-1
1.000E0
 1 119
49 hsa-miR-1224-5p:PITA hsa-miR-1224-5p:PITA TOP PITA 1.343E-2 4.977E-2
2.930E-1
1.000E0
 1 122
50 hsa-miR-486-5p:TargetScan hsa-miR-486-5p TargetScan 1.354E-2 4.977E-2
2.930E-1
1.000E0
 1 123
Show 45 more annotations

17: Drug [Display Chart] 8 input genes in category / 3141 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000423574 4-amino-5-oxohexanoic acid Stitch 1.391E-15 4.368E-12 3.769E-11 4.368E-12 5 13
2 CID000002182 anagrelide Stitch 5.408E-13 8.494E-10 7.330E-9 1.699E-9 5 38
3 CID000114777 theaflavin Stitch 2.292E-11 2.400E-8 2.071E-7 7.199E-8 6 224
4 CID000484125 K-S-L Stitch 5.053E-10 3.968E-7 3.424E-6 1.587E-6 4 39
5 CID000011885 1-aminoanthracene Stitch 8.334E-10 5.164E-7 4.456E-6 2.618E-6 4 44
6 CID003040611 diaminofluorene Stitch 9.864E-10 5.164E-7 4.456E-6 3.098E-6 3 7
7 CID000067050 rhodizonic acid Stitch 1.184E-9 5.313E-7 4.585E-6 3.719E-6 5 170
8 CID000149352 eilatin Stitch 2.366E-9 9.291E-7 8.018E-6 7.433E-6 3 9
9 CID000003653 AC1L1GEZ Stitch 2.684E-9 9.367E-7 8.083E-6 8.430E-6 5 200
10 CID005288624 IM-E Stitch 3.416E-9 1.052E-6 9.082E-6 1.073E-5 4 62
11 CID000002141 amifostine Stitch 4.144E-9 1.052E-6 9.082E-6 1.302E-5 4 65
12 CID000004131 AC1Q6S8H Stitch 4.411E-9 1.052E-6 9.082E-6 1.386E-5 4 66
13 CID000087583 M57-15 Stitch 4.647E-9 1.052E-6 9.082E-6 1.460E-5 3 11
14 CID000003690 ifosfamide Stitch 4.691E-9 1.052E-6 9.082E-6 1.473E-5 4 67
15 CID000004602 PHPs Stitch 1.025E-8 2.146E-6 1.852E-5 3.218E-5 3 14
16 CID000000979 p-hydroxyphenylpyruvate Stitch 1.630E-8 3.200E-6 2.762E-5 5.120E-5 4 91
17 CID000001351 AC1L1BA8 Stitch 2.295E-8 4.241E-6 3.660E-5 7.210E-5 3 18
18 CID003035022 GLA-60 Stitch 2.725E-8 4.756E-6 4.104E-5 8.561E-5 3 19
19 CID000038904 carboplatin Stitch 7.106E-8 1.175E-5 1.014E-4 2.232E-4 4 131
20 CID003073192 TMD I Stitch 1.073E-7 1.606E-5 1.386E-4 3.372E-4 2 2
21 CID003024442 UCB 8 Stitch 1.073E-7 1.606E-5 1.386E-4 3.372E-4 2 2
22 CID000009012 m262 Stitch 3.217E-7 4.397E-5 3.795E-4 1.010E-3 3 42
23 CID000101443 py80 Stitch 3.220E-7 4.397E-5 3.795E-4 1.011E-3 2 3
24 CID003060738 Hs 5 Stitch 4.540E-7 5.941E-5 5.127E-4 1.426E-3 3 47
25 CID000017893 PY74 Stitch 6.438E-7 8.065E-5 6.960E-4 2.022E-3 2 4
26 CID000005426 thalidomide Stitch 6.676E-7 8.065E-5 6.960E-4 2.097E-3 4 229
27 CID000097711 g130 Stitch 9.560E-7 1.112E-4 9.598E-4 3.003E-3 3 60
28 CID000000875 tartarate Stitch 1.213E-6 1.361E-4 1.175E-3 3.812E-3 4 266
29 CID000004070 M EG Stitch 1.277E-6 1.383E-4 1.194E-3 4.012E-3 3 66
30 CID000072508 pip-pip Stitch 1.398E-6 1.464E-4 1.263E-3 4.392E-3 3 68
31 ctd:C552240 StemRegenin 1 CTD 1.609E-6 1.630E-4 1.407E-3 5.054E-3 2 6
32 CID000038347 4-HC Stitch 1.663E-6 1.632E-4 1.409E-3 5.223E-3 3 72
33 CID000449244 1yei Stitch 1.734E-6 1.650E-4 1.424E-3 5.446E-3 3 73
34 ctd:C117153 tetracycline CMT-8 CTD 2.252E-6 2.081E-4 1.796E-3 7.074E-3 2 7
35 CID000007111 benzidine Stitch 2.375E-6 2.132E-4 1.840E-3 7.461E-3 3 81
36 CID000001361 AC1L1BB2 Stitch 2.557E-6 2.231E-4 1.925E-3 8.032E-3 3 83
37 CID000002907 cyclophosphamide Stitch 2.759E-6 2.342E-4 2.021E-3 8.667E-3 4 327
38 CID000496913 neoR Stitch 2.847E-6 2.353E-4 2.031E-3 8.942E-3 3 86
39 ctd:C021139 anagrelide CTD 3.002E-6 2.418E-4 2.087E-3 9.431E-3 2 8
40 CID000002478 busulfan Stitch 4.094E-6 3.215E-4 2.774E-3 1.286E-2 3 97
41 CID009846180 X5021 Stitch 4.824E-6 3.695E-4 3.189E-3 1.515E-2 2 10
42 CID000002934 2-(N-myristoylamino)-1-phenyl-1-propanol Stitch 5.895E-6 4.408E-4 3.804E-3 1.851E-2 2 11
43 CID005288823 heptamolybdate Stitch 6.313E-6 4.507E-4 3.889E-3 1.983E-2 3 112
44 CID000005309 IN1076 Stitch 6.313E-6 4.507E-4 3.889E-3 1.983E-2 3 112
45 CID000005291 imatinib Stitch 8.167E-6 5.700E-4 4.919E-3 2.565E-2 4 430
46 CID000486173 AC1LADSU Stitch 8.357E-6 5.706E-4 4.924E-3 2.625E-2 2 13
47 CID000003657 hydroxyurea Stitch 8.784E-6 5.870E-4 5.066E-3 2.759E-2 4 438
48 ctd:C477898 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid CTD 9.748E-6 6.379E-4 5.505E-3 3.062E-2 2 14
49 ctd:C054105 ammonium trichloro(dioxoethylene-O,O'-)tellurate CTD 1.285E-5 7.931E-4 6.844E-3 4.036E-2 2 16
50 CID000004365 AC1Q6QQN Stitch 1.285E-5 7.931E-4 6.844E-3 4.036E-2 2 16
Show 45 more annotations

18: Disease [Display Chart] 8 input genes in category / 694 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0032463 Polycythemia Vera DisGeNET Curated 8.208E-11 5.697E-8 4.056E-7 5.697E-8 6 197
2 C0026985 Myelodysplasia DisGeNET Curated 3.085E-10 1.070E-7 7.622E-7 2.141E-7 5 93
3 C0023462 Acute Megakaryocytic Leukemias DisGeNET Curated 1.225E-9 2.834E-7 2.018E-6 8.501E-7 5 122
4 C1260899 Anemia, Diamond-Blackfan DisGeNET Curated 1.630E-8 2.828E-6 2.014E-5 1.131E-5 4 65
5 C1292778 Chronic myeloproliferative disorder DisGeNET BeFree 3.322E-8 3.925E-6 2.795E-5 2.306E-5 5 235
6 C0023530 Leukopenia DisGeNET Curated 3.394E-8 3.925E-6 2.795E-5 2.355E-5 5 236
7 C0027022 Myeloproliferative disease DisGeNET Curated 4.902E-8 4.860E-6 3.461E-5 3.402E-5 5 254
8 C0040034 Thrombocytopenia DisGeNET Curated 1.126E-7 9.764E-6 6.952E-5 7.811E-5 5 300
9 C2981142 Refractory anemia, without ringed sideroblasts, without excess blasts DisGeNET BeFree 3.527E-7 2.452E-5 1.746E-4 2.448E-4 3 31
10 C0040028 Thrombocythemia, Essential DisGeNET Curated 3.533E-7 2.452E-5 1.746E-4 2.452E-4 4 139
11 C4273671 Inherited predisposition to essential thrombocythemia DisGeNET BeFree 6.396E-7 3.097E-5 2.205E-4 4.439E-4 2 3
12 C3281125 THROMBOCYTHEMIA 3 DisGeNET Curated 6.396E-7 3.097E-5 2.205E-4 4.439E-4 2 3
13 C3277671 THROMBOCYTHEMIA 1 DisGeNET Curated 6.396E-7 3.097E-5 2.205E-4 4.439E-4 2 3
14 C3275998 THROMBOCYTHEMIA 2 DisGeNET Curated 6.396E-7 3.097E-5 2.205E-4 4.439E-4 2 3
15 C0001815 Primary Myelofibrosis DisGeNET Curated 6.693E-7 3.097E-5 2.205E-4 4.645E-4 4 163
16 C0238644 Anemia, severe DisGeNET BeFree 8.345E-7 3.619E-5 2.577E-4 5.791E-4 3 41
17 C0042487 Venous Thrombosis DisGeNET Curated 1.187E-6 4.845E-5 3.450E-4 8.237E-4 3 46
18 C0836924 Thrombocytosis DisGeNET Curated 1.626E-6 6.271E-5 4.465E-4 1.129E-3 3 51
19 OMIN:187950 THROMBOCYTHEMIA, ESSENTIAL OMIM 2.131E-6 7.395E-5 5.265E-4 1.479E-3 2 5
20 C1401086 Peripheral vascular insufficiency DisGeNET Curated 2.131E-6 7.395E-5 5.265E-4 1.479E-3 2 5
21 C1834582 MYELOPROLIFERATIVE SYNDROME, TRANSIENT DisGeNET Curated 2.804E-6 9.267E-5 6.599E-4 1.946E-3 3 61
22 C1327915 Congenital amegakaryocytic thrombocytopenia DisGeNET Curated 3.196E-6 9.643E-5 6.866E-4 2.218E-3 2 6
23 C0549414 Blast cell proliferation DisGeNET BeFree 3.196E-6 9.643E-5 6.866E-4 2.218E-3 2 6
24 C0023474 Leukemia, Myeloid, Chronic-Phase DisGeNET BeFree 4.833E-6 1.397E-4 9.950E-4 3.354E-3 3 73
25 C0175703 Thrombocytopenia-Absent Radius Syndrome DisGeNET Curated 5.963E-6 1.655E-4 1.179E-3 4.138E-3 2 8
26 C0151942 Arterial thrombosis DisGeNET Curated 7.664E-6 1.970E-4 1.403E-3 5.319E-3 2 9
27 C0750145 vascular disease occlusive DisGeNET Curated 7.664E-6 1.970E-4 1.403E-3 5.319E-3 2 9
28 C0026987 Myelofibrosis DisGeNET Curated 9.092E-6 2.254E-4 1.605E-3 6.310E-3 3 90
29 C0023480 Leukemia, Myelomonocytic, Chronic DisGeNET Curated 1.446E-5 3.460E-4 2.464E-3 1.003E-2 3 105
30 C0272278 Congenital thrombocytopenia DisGeNET Curated 1.659E-5 3.714E-4 2.644E-3 1.151E-2 2 13
31 C1854520 SEBASTIAN SYNDROME DisGeNET Curated 1.659E-5 3.714E-4 2.644E-3 1.151E-2 2 13
32 C0857460 Increased number of platelets DisGeNET Curated 1.935E-5 4.196E-4 2.988E-3 1.343E-2 2 14
33 C0033027 Preleukemia DisGeNET BeFree 2.232E-5 4.694E-4 3.342E-3 1.549E-2 2 15
34 C0002871 Anemia DisGeNET Curated 3.381E-5 6.901E-4 4.914E-3 2.346E-2 4 438
35 C0152264 Familial erythrocytosis DisGeNET Curated 3.632E-5 7.201E-4 5.127E-3 2.520E-2 2 19
36 C0023470 Myeloid Leukemia DisGeNET Curated 5.001E-5 9.640E-4 6.864E-3 3.471E-2 4 484
37 C0085669 Acute leukemia DisGeNET Curated 5.290E-5 9.668E-4 6.884E-3 3.671E-2 4 491
38 C0027947 Neutropenia DisGeNET Curated 5.294E-5 9.668E-4 6.884E-3 3.674E-2 3 162
39 C0398650 Immune thrombocytopenic purpura DisGeNET Curated 6.328E-5 1.126E-3 8.018E-3 4.392E-2 3 172
40 C1883018 Severe Aplastic Anemia DisGeNET BeFree 6.890E-5 1.195E-3 8.512E-3 4.782E-2 2 26
41 C1306889 Peripheral arterial occlusive disease DisGeNET Curated 7.439E-5 1.259E-3 8.967E-3
5.163E-2
 2 27
42 C0917805 Transient Cerebral Ischemia DisGeNET Curated 8.601E-5 1.421E-3 1.012E-2
5.969E-2
 2 29
43 C0023448 Lymphoid leukemia DisGeNET Curated 9.191E-5 1.483E-3 1.056E-2
6.378E-2
 3 195
44 C0002894 Refractory anaemia with excess blasts DisGeNET Curated 1.050E-4 1.619E-3 1.153E-2
7.287E-2
 2 32
45 C1802398 Chromosome 5, trisomy 5q DisGeNET BeFree 1.050E-4 1.619E-3 1.153E-2
7.287E-2
 2 32
46 C1292779 Myelodysplastic Syndrome with Isolated del(5q) DisGeNET BeFree 1.117E-4 1.686E-3 1.200E-2
7.755E-2
 2 33
47 C0030554 Paresthesia DisGeNET Curated 1.332E-4 1.926E-3 1.372E-2
9.246E-2
 2 36
48 C0740302 5q-syndrome DisGeNET Curated 1.332E-4 1.926E-3 1.372E-2
9.246E-2
 2 36
49 C1458140 Bleeding tendency DisGeNET Curated 1.408E-4 1.994E-3 1.420E-2
9.772E-2
 2 37
50 C0272286 Thrombocytopenia due to platelet alloimmunization DisGeNET BeFree 2.183E-4 3.031E-3 2.158E-2
1.515E-1
 2 46
Show 45 more annotations