Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc236_8, positive side

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1: GO: Molecular Function [Display Chart] 8 input genes in category / 25 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005173 stem cell factor receptor binding 2.068E-10 5.170E-9 1.973E-8 5.170E-9 3 4
2 GO:0035256 G protein-coupled glutamate receptor binding 4.339E-9 5.423E-8 2.070E-7 1.085E-7 3 9
3 GO:0035254 glutamate receptor binding 7.783E-7 6.485E-6 2.475E-5 1.946E-5 3 46
4 GO:0005522 profilin binding 1.059E-5 6.620E-5 2.526E-4 2.648E-4 2 12
5 GO:0030291 protein serine/threonine kinase inhibitor activity 6.954E-5 3.477E-4 1.327E-3 1.738E-3 2 30
6 GO:0001664 G protein-coupled receptor binding 1.696E-4 6.941E-4 2.648E-3 4.241E-3 3 276
7 GO:0005126 cytokine receptor binding 1.943E-4 6.941E-4 2.648E-3 4.858E-3 3 289
8 GO:0032947 protein-containing complex scaffold activity 4.751E-4 1.468E-3 5.603E-3 1.188E-2 2 78
9 GO:0003779 actin binding 5.509E-4 1.468E-3 5.603E-3 1.377E-2 3 412
10 GO:0004860 protein kinase inhibitor activity 6.181E-4 1.468E-3 5.603E-3 1.545E-2 2 89
11 GO:0019210 kinase inhibitor activity 6.461E-4 1.468E-3 5.603E-3 1.615E-2 2 91
12 GO:0017124 SH3 domain binding 1.176E-3 2.449E-3 9.347E-3 2.939E-2 2 123
13 GO:0031802 type 5 metabotropic glutamate receptor binding 1.286E-3 2.472E-3 9.434E-3 3.214E-2 1 3
14 GO:0030160 GKAP/Homer scaffold activity 1.714E-3 3.060E-3 1.168E-2 4.285E-2 1 4
15 GO:0019887 protein kinase regulator activity 2.918E-3 4.864E-3 1.856E-2
7.296E-2
 2 195
16 GO:0019207 kinase regulator activity 3.567E-3 5.573E-3 2.127E-2
8.916E-2
 2 216
17 GO:0030159 receptor signaling complex scaffold activity 1.109E-2 1.582E-2
6.036E-2
2.774E-1
 1 26
18 GO:0004857 enzyme inhibitor activity 1.139E-2 1.582E-2
6.036E-2
2.847E-1
 2 393
19 GO:0050699 WW domain binding 1.406E-2 1.850E-2
7.061E-2
3.516E-1
 1 33
20 GO:0097110 scaffold protein binding 2.334E-2 2.918E-2
1.113E-1
5.835E-1
 1 55
21 GO:0035591 signaling adaptor activity 3.296E-2 3.924E-2
1.497E-1
8.240E-1
 1 78
Show 16 more annotations

2: GO: Biological Process [Display Chart] 8 input genes in category / 135 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007216 G protein-coupled glutamate receptor signaling pathway 1.890E-8 2.551E-6 1.400E-5 2.551E-6 3 14
2 GO:0000188 inactivation of MAPK activity 1.891E-7 1.277E-5 7.004E-5 2.553E-5 3 29
3 GO:0007215 glutamate receptor signaling pathway 3.463E-6 1.421E-4 7.793E-4 4.675E-4 3 75
4 GO:0043407 negative regulation of MAP kinase activity 4.209E-6 1.421E-4 7.793E-4 5.682E-4 3 80
5 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 1.257E-5 3.393E-4 1.861E-3 1.696E-3 2 13
6 GO:0048875 chemical homeostasis within a tissue 1.691E-5 3.505E-4 1.923E-3 2.283E-3 2 15
7 GO:0010801 negative regulation of peptidyl-threonine phosphorylation 1.932E-5 3.505E-4 1.923E-3 2.608E-3 2 16
8 GO:0071901 negative regulation of protein serine/threonine kinase activity 2.077E-5 3.505E-4 1.923E-3 2.804E-3 3 136
9 GO:0048148 behavioral response to cocaine 2.462E-5 3.693E-4 2.026E-3 3.324E-3 2 18
10 GO:1901798 positive regulation of signal transduction by p53 class mediator 3.056E-5 4.126E-4 2.264E-3 4.126E-3 2 20
11 GO:0043409 negative regulation of MAPK cascade 3.769E-5 4.626E-4 2.538E-3 5.088E-3 3 166
12 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 6.982E-5 7.855E-4 4.309E-3 9.426E-3 2 30
13 GO:0006469 negative regulation of protein kinase activity 1.259E-4 1.182E-3 6.483E-3 1.699E-2 3 249
14 GO:0010799 regulation of peptidyl-threonine phosphorylation 1.313E-4 1.182E-3 6.483E-3 1.773E-2 2 41
15 GO:0090311 regulation of protein deacetylation 1.313E-4 1.182E-3 6.483E-3 1.773E-2 2 41
16 GO:0033673 negative regulation of kinase activity 1.688E-4 1.425E-3 7.815E-3 2.279E-2 3 275
17 GO:0042220 response to cocaine 2.371E-4 1.883E-3 1.033E-2 3.201E-2 2 55
18 GO:0043405 regulation of MAP kinase activity 3.612E-4 2.709E-3 1.486E-2 4.876E-2 3 356
19 GO:2001022 positive regulation of response to DNA damage stimulus 3.843E-4 2.731E-3 1.498E-2
5.188E-2
 2 70
20 GO:0051348 negative regulation of transferase activity 4.307E-4 2.907E-3 1.595E-2
5.814E-2
 3 378
21 GO:0018107 peptidyl-threonine phosphorylation 5.932E-4 3.749E-3 2.057E-2
8.008E-2
 2 87
22 GO:0001933 negative regulation of protein phosphorylation 6.110E-4 3.749E-3 2.057E-2
8.248E-2
 3 426
23 GO:0018210 peptidyl-threonine modification 6.487E-4 3.758E-3 2.062E-2
8.758E-2
 2 91
24 GO:0006476 protein deacetylation 7.827E-4 3.758E-3 2.062E-2
1.057E-1
 2 100
25 GO:0042326 negative regulation of phosphorylation 8.290E-4 3.758E-3 2.062E-2
1.119E-1
 3 473
26 GO:0001843 neural tube closure 8.300E-4 3.758E-3 2.062E-2
1.121E-1
 2 103
27 GO:0060606 tube closure 8.461E-4 3.758E-3 2.062E-2
1.142E-1
 2 104
28 GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 8.590E-4 3.758E-3 2.062E-2
1.160E-1
 1 2
29 GO:0035601 protein deacylation 8.624E-4 3.758E-3 2.062E-2
1.164E-1
 2 105
30 GO:0098732 macromolecule deacylation 8.788E-4 3.758E-3 2.062E-2
1.186E-1
 2 106
31 GO:0030330 DNA damage response, signal transduction by p53 class mediator 9.120E-4 3.758E-3 2.062E-2
1.231E-1
 2 108
32 GO:0014020 primary neural tube formation 9.120E-4 3.758E-3 2.062E-2
1.231E-1
 2 108
33 GO:1902532 negative regulation of intracellular signal transduction 9.186E-4 3.758E-3 2.062E-2
1.240E-1
 3 490
34 GO:0008543 fibroblast growth factor receptor signaling pathway 9.977E-4 3.962E-3 2.173E-2
1.347E-1
 2 113
35 GO:0001841 neural tube formation 1.143E-3 4.356E-3 2.390E-2
1.543E-1
 2 121
36 GO:0042770 signal transduction in response to DNA damage 1.162E-3 4.356E-3 2.390E-2
1.568E-1
 2 122
37 GO:0044344 cellular response to fibroblast growth factor stimulus 1.440E-3 5.255E-3 2.883E-2
1.944E-1
 2 136
38 GO:0071774 response to fibroblast growth factor 1.569E-3 5.442E-3 2.986E-2
2.118E-1
 2 142
39 GO:0001838 embryonic epithelial tube formation 1.591E-3 5.442E-3 2.986E-2
2.147E-1
 2 143
40 GO:0072175 epithelial tube formation 1.613E-3 5.442E-3 2.986E-2
2.177E-1
 2 144
41 GO:2001020 regulation of response to DNA damage stimulus 1.889E-3 6.148E-3 3.373E-2
2.550E-1
 2 156
42 GO:0043279 response to alkaloid 1.913E-3 6.148E-3 3.373E-2
2.582E-1
 2 157
43 GO:0035148 tube formation 1.961E-3 6.157E-3 3.378E-2
2.647E-1
 2 159
44 GO:1901796 regulation of signal transduction by p53 class mediator 2.160E-3 6.628E-3 3.636E-2
2.916E-1
 2 167
45 GO:0030534 adult behavior 2.237E-3 6.712E-3 3.682E-2
3.020E-1
 2 170
46 GO:0016331 morphogenesis of embryonic epithelium 2.289E-3 6.719E-3 3.686E-2
3.091E-1
 2 172
47 GO:0021915 neural tube development 2.614E-3 7.509E-3 4.120E-2
3.529E-1
 2 184
48 GO:0008154 actin polymerization or depolymerization 2.842E-3 7.994E-3 4.386E-2
3.837E-1
 2 192
49 GO:2001256 regulation of store-operated calcium entry 3.860E-3 1.064E-2
5.835E-2
5.212E-1
 1 9
50 GO:0001894 tissue homeostasis 4.329E-3 1.152E-2
6.318E-2
5.844E-1
 2 238
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 8 input genes in category / 47 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0098858 actin-based cell projection 6.502E-5 1.120E-3 4.969E-3 3.056E-3 3 204
2 GO:0045211 postsynaptic membrane 8.700E-5 1.120E-3 4.969E-3 4.089E-3 3 225
3 GO:0014069 postsynaptic density 9.528E-5 1.120E-3 4.969E-3 4.478E-3 3 232
4 GO:0099572 postsynaptic specialization 9.528E-5 1.120E-3 4.969E-3 4.478E-3 3 232
5 GO:0060076 excitatory synapse 1.218E-4 1.144E-3 5.079E-3 5.722E-3 3 252
6 GO:0097060 synaptic membrane 1.999E-4 1.566E-3 6.949E-3 9.394E-3 3 298
7 GO:0098794 postsynapse 6.657E-4 4.470E-3 1.984E-2 3.129E-2 3 449
8 GO:0030175 filopodium 7.775E-4 4.568E-3 2.027E-2 3.654E-2 2 102
9 GO:0030027 lamellipodium 2.551E-3 1.332E-2
5.913E-2
1.199E-1
 2 186
10 GO:0032426 stereocilium tip 5.444E-3 2.559E-2
1.136E-1
2.559E-1
 1 13
11 GO:0031258 lamellipodium membrane 7.948E-3 3.113E-2
1.382E-1
3.736E-1
 1 19
12 GO:0031527 filopodium membrane 7.948E-3 3.113E-2
1.382E-1
3.736E-1
 1 19
13 GO:0043034 costamere 8.782E-3 3.173E-2
1.408E-1
4.127E-1
 1 21
14 GO:0031252 cell leading edge 1.072E-2 3.173E-2
1.408E-1
5.040E-1
 2 389
15 GO:0005925 focal adhesion 1.094E-2 3.173E-2
1.408E-1
5.140E-1
 2 393
16 GO:0005924 cell-substrate adherens junction 1.120E-2 3.173E-2
1.408E-1
5.266E-1
 2 398
17 GO:0030055 cell-substrate junction 1.148E-2 3.173E-2
1.408E-1
5.394E-1
 2 403
18 GO:0045177 apical part of cell 1.288E-2 3.362E-2
1.492E-1
6.052E-1
 2 428
19 GO:0015629 actin cytoskeleton 1.577E-2 3.825E-2
1.698E-1
7.412E-1
 2 476
20 GO:0005912 adherens junction 1.628E-2 3.825E-2
1.698E-1
7.651E-1
 2 484
21 GO:0032420 stereocilium 1.832E-2 4.101E-2
1.820E-1
8.611E-1
 1 44
22 GO:0032421 stereocilium bundle 2.203E-2 4.707E-2
2.089E-1
1.000E0
 1 53
Show 17 more annotations

4: Human Phenotype [Display Chart] 1 input genes in category / 44 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 8 input genes in category / 140 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002736 abnormal nociception after inflammation 3.426E-6 4.797E-4 2.649E-3 4.797E-4 3 42
2 MP:0009027 abnormal subarachnoid space morphology 1.095E-5 6.561E-4 3.623E-3 1.533E-3 2 7
3 MP:0009026 abnormal brain pia mater morphology 1.875E-5 6.561E-4 3.623E-3 2.625E-3 2 9
4 MP:0009713 enhanced conditioned place preference behavior 2.343E-5 6.561E-4 3.623E-3 3.280E-3 2 10
5 MP:0011724 ectopic cortical neuron 2.343E-5 6.561E-4 3.623E-3 3.280E-3 2 10
6 MP:0008457 abnormal cortical intermediate zone morphology 3.434E-5 8.013E-4 4.425E-3 4.808E-3 2 12
7 MP:0008129 absent brain internal capsule 5.457E-5 1.091E-3 6.027E-3 7.640E-3 2 15
8 MP:0011112 lethality during fetal growth through weaning, incomplete penetrance 7.062E-5 1.099E-3 6.067E-3 9.887E-3 2 17
9 MP:0009022 abnormal brain meninges morphology 7.062E-5 1.099E-3 6.067E-3 9.887E-3 2 17
10 MP:0009754 enhanced behavioral response to cocaine 1.553E-4 2.174E-3 1.201E-2 2.174E-2 2 25
11 MP:0005623 abnormal meninges morphology 1.955E-4 2.488E-3 1.374E-2 2.736E-2 2 28
12 MP:0009711 abnormal conditioned place preference behavior 3.248E-4 3.621E-3 2.000E-2 4.547E-2 2 36
13 MP:0020158 abnormal behavioral response to cocaine 3.432E-4 3.621E-3 2.000E-2 4.805E-2 2 37
14 MP:0003648 abnormal radial glial cell morphology 3.621E-4 3.621E-3 2.000E-2
5.070E-2
 2 38
15 MP:0012316 enhanced conditioning behavior 4.428E-4 3.875E-3 2.140E-2
6.199E-2
 2 42
16 MP:0008128 abnormal brain internal capsule morphology 4.428E-4 3.875E-3 2.140E-2
6.199E-2
 2 42
17 MP:0008439 abnormal cortical plate morphology 5.549E-4 4.570E-3 2.524E-2
7.768E-2
 2 47
18 MP:0008254 increased megakaryocyte cell number 6.032E-4 4.691E-3 2.591E-2
8.444E-2
 2 49
19 MP:0009749 enhanced behavioral response to addictive substance 6.534E-4 4.815E-3 2.659E-2
9.148E-2
 2 51
20 MP:0002192 hydrops fetalis 1.093E-3 7.651E-3 4.225E-2
1.530E-1
 2 66
21 MP:0001968 abnormal touch/ nociception 1.269E-3 8.462E-3 4.673E-2
1.777E-1
 3 305
22 MP:0011723 ectopic neuron 1.523E-3 9.508E-3
5.251E-2
2.132E-1
 2 78
23 MP:0009746 enhanced behavioral response to xenobiotic 1.562E-3 9.508E-3
5.251E-2
2.187E-1
 2 79
24 MP:0003566 abnormal cell adhesion 1.764E-3 1.029E-2
5.682E-2
2.470E-1
 2 84
25 MP:0002556 abnormal cocaine consumption 2.316E-3 1.297E-2
7.163E-2
3.243E-1
 1 3
26 MP:0009748 abnormal behavioral response to addictive substance 2.740E-3 1.476E-2
8.149E-2
3.837E-1
 2 105
27 MP:0002417 abnormal megakaryocyte morphology 3.003E-3 1.557E-2
8.599E-2
4.204E-1
 2 110
28 MP:0013660 abnormal bone marrow hematopoietic cell morphology 3.505E-3 1.752E-2
9.678E-2
4.907E-1
 2 119
29 MP:0008415 abnormal neurite morphology 4.254E-3 2.054E-2
1.134E-1
5.956E-1
 3 465
30 MP:0000934 abnormal telencephalon development 6.950E-3 3.244E-2
1.791E-1
9.731E-1
 2 169
31 MP:0011380 enlarged brain ventricles 7.192E-3 3.248E-2
1.794E-1
1.000E0
 2 172
32 MP:0001891 hydroencephaly 7.602E-3 3.326E-2
1.837E-1
1.000E0
 2 177
33 MP:0013229 abnormal brain ventricle size 7.939E-3 3.368E-2
1.860E-1
1.000E0
 2 181
34 MP:0009586 increased platelet aggregation 8.470E-3 3.487E-2
1.926E-1
1.000E0
 1 11
35 MP:0008764 increased mast cell degranulation 9.236E-3 3.695E-2
2.040E-1
1.000E0
 1 12
Show 30 more annotations

6: Domain [Display Chart] 8 input genes in category / 16 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00568 WH1 Pfam 4.390E-28 2.341E-27 7.915E-27 7.023E-27 8 11
2 SM00461 WH1 SMART 4.390E-28 2.341E-27 7.915E-27 7.023E-27 8 11
3 IPR000697 WH1/EVH1 dom InterPro 4.390E-28 2.341E-27 7.915E-27 7.023E-27 8 11
4 PS50229 WH1 PROSITE 3.424E-27 1.370E-26 4.630E-26 5.478E-26 8 13
5 2.30.29.30 - Gene3D 3.354E-14 1.073E-13 3.628E-13 5.366E-13 8 391
6 IPR011993 PH dom-like InterPro 6.826E-14 1.820E-13 6.154E-13 1.092E-12 8 427
7 PS51488 KBD PROSITE 5.110E-11 1.022E-10 3.455E-10 8.177E-10 3 3
8 IPR023337 KBD InterPro 5.110E-11 1.022E-10 3.455E-10 8.177E-10 3 3
9 PS51227 SPR PROSITE 1.787E-9 2.600E-9 8.788E-9 2.859E-8 3 7
10 IPR007875 Sprouty InterPro 1.787E-9 2.600E-9 8.788E-9 2.859E-8 3 7
11 PF05210 Sprouty Pfam 1.787E-9 2.600E-9 8.788E-9 2.859E-8 3 7
12 IPR014885 VASP tetra InterPro 4.786E-7 5.890E-7 1.991E-6 7.657E-6 2 3
13 PF08776 VASP tetra Pfam 4.786E-7 5.890E-7 1.991E-6 7.657E-6 2 3
14 IPR017354 Vasodilator phosphoprotein InterPro 8.539E-4 9.758E-4 3.299E-3 1.366E-2 1 2
15 SM00160 RanBD SMART 5.539E-3 5.539E-3 1.872E-2
8.862E-2
 1 13
16 IPR000156 Ran bind dom InterPro 5.539E-3 5.539E-3 1.872E-2
8.862E-2
 1 13
Show 11 more annotations

7: Pathway [Display Chart] 8 input genes in category / 80 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1383029 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases BioSystems: REACTOME 5.662E-7 4.530E-5 2.249E-4 4.530E-5 3 28
2 1427850 Interactions of neurexins and neuroligins at synapses BioSystems: REACTOME 5.567E-6 1.697E-4 8.426E-4 4.453E-4 3 59
3 1383025 Signaling by PTK6 BioSystems: REACTOME 8.558E-6 1.697E-4 8.426E-4 6.847E-4 3 68
4 1427849 Protein-protein interactions at synapses BioSystems: REACTOME 1.061E-5 1.697E-4 8.426E-4 8.484E-4 3 73
5 1269290 Regulation of RAS by GAPs BioSystems: REACTOME 1.061E-5 1.697E-4 8.426E-4 8.484E-4 3 73
6 1383021 FGFRL1 modulation of FGFR1 signaling BioSystems: REACTOME 2.808E-5 3.744E-4 1.859E-3 2.247E-3 2 13
7 213818 Glutamatergic synapse BioSystems: KEGG 4.050E-5 4.628E-4 2.298E-3 3.240E-3 3 114
8 921162 FoxO signaling pathway BioSystems: KEGG 6.275E-5 6.275E-4 3.116E-3 5.020E-3 3 132
9 1270318 Signaling by Robo receptor BioSystems: REACTOME 1.889E-4 1.404E-3 6.971E-3 1.511E-2 2 33
10 1269175 Generation of second messenger molecules BioSystems: REACTOME 2.252E-4 1.404E-3 6.971E-3 1.801E-2 2 36
11 137918 Stabilization and expansion of the E-cadherin adherens junction BioSystems: Pathway Interaction Database 2.784E-4 1.404E-3 6.971E-3 2.227E-2 2 40
12 1269440 SOS-mediated signalling BioSystems: REACTOME 4.061E-4 1.404E-3 6.971E-3 3.249E-2 3 248
13 1269383 SHC1 events in EGFR signaling BioSystems: REACTOME 4.061E-4 1.404E-3 6.971E-3 3.249E-2 3 248
14 1269382 GRB2 events in EGFR signaling BioSystems: REACTOME 4.061E-4 1.404E-3 6.971E-3 3.249E-2 3 248
15 1269285 RAF/MAP kinase cascade BioSystems: REACTOME 4.061E-4 1.404E-3 6.971E-3 3.249E-2 3 248
16 1269471 ARMS-mediated activation BioSystems: REACTOME 4.256E-4 1.404E-3 6.971E-3 3.405E-2 3 252
17 1269468 Signalling to p38 via RIT and RIN BioSystems: REACTOME 4.256E-4 1.404E-3 6.971E-3 3.405E-2 3 252
18 1269470 Frs2-mediated activation BioSystems: REACTOME 4.306E-4 1.404E-3 6.971E-3 3.445E-2 3 253
19 1269502 MAPK1/MAPK3 signaling BioSystems: REACTOME 4.356E-4 1.404E-3 6.971E-3 3.485E-2 3 254
20 1269387 Signaling by FGFR1 BioSystems: REACTOME 4.358E-4 1.404E-3 6.971E-3 3.487E-2 2 50
21 1269469 Prolonged ERK activation events BioSystems: REACTOME 4.407E-4 1.404E-3 6.971E-3 3.525E-2 3 255
22 1269632 Signaling by Leptin BioSystems: REACTOME 4.458E-4 1.404E-3 6.971E-3 3.566E-2 3 256
23 1269322 Interleukin receptor SHC signaling BioSystems: REACTOME 4.561E-4 1.404E-3 6.971E-3 3.648E-2 3 258
24 1269465 Signalling to RAS BioSystems: REACTOME 4.613E-4 1.404E-3 6.971E-3 3.690E-2 3 259
25 138068 Signaling events mediated by Stem cell factor receptor (c-Kit) BioSystems: Pathway Interaction Database 4.715E-4 1.404E-3 6.971E-3 3.772E-2 2 52
26 1269485 VEGFR2 mediated cell proliferation BioSystems: REACTOME 4.718E-4 1.404E-3 6.971E-3 3.774E-2 3 261
27 1269321 Interleukin-2 signaling BioSystems: REACTOME 4.933E-4 1.404E-3 6.971E-3 3.946E-2 3 265
28 1269464 Signalling to ERKs BioSystems: REACTOME 4.988E-4 1.404E-3 6.971E-3 3.990E-2 3 266
29 1427866 RET signaling BioSystems: REACTOME 5.382E-4 1.404E-3 6.971E-3 4.306E-2 3 273
30 1269299 FCERI mediated MAPK activation BioSystems: REACTOME 5.440E-4 1.404E-3 6.971E-3 4.352E-2 3 274
31 1269323 Interleukin-3, 5 and GM-CSF signaling BioSystems: REACTOME 5.440E-4 1.404E-3 6.971E-3 4.352E-2 3 274
32 1270312 NCAM signaling for neurite out-growth BioSystems: REACTOME 5.736E-4 1.434E-3 7.120E-3 4.588E-2 3 279
33 1269501 MAPK family signaling cascades BioSystems: REACTOME 6.618E-4 1.537E-3 7.630E-3
5.295E-2
 3 293
34 1269431 IRS-mediated signalling BioSystems: REACTOME 6.953E-4 1.537E-3 7.630E-3
5.563E-2
 3 298
35 1269429 Insulin receptor signalling cascade BioSystems: REACTOME 7.160E-4 1.537E-3 7.630E-3
5.728E-2
 3 301
36 1269618 IGF1R signaling cascade BioSystems: REACTOME 7.229E-4 1.537E-3 7.630E-3
5.783E-2
 3 302
37 1269620 IRS-related events triggered by IGF1R BioSystems: REACTOME 7.229E-4 1.537E-3 7.630E-3
5.783E-2
 3 302
38 1269617 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) BioSystems: REACTOME 7.299E-4 1.537E-3 7.630E-3
5.839E-2
 3 303
39 1269428 Signaling by Insulin receptor BioSystems: REACTOME 9.034E-4 1.853E-3 9.201E-3
7.227E-2
 3 326
40 1269483 VEGFA-VEGFR2 Pathway BioSystems: REACTOME 9.609E-4 1.922E-3 9.543E-3
7.688E-2
 3 333
41 1269487 Signaling by SCF-KIT BioSystems: REACTOME 1.021E-3 1.961E-3 9.738E-3
8.167E-2
 3 340
42 1269480 Signaling by VEGF BioSystems: REACTOME 1.030E-3 1.961E-3 9.738E-3
8.237E-2
 3 341
43 1268763 Neuronal System BioSystems: REACTOME 1.120E-3 2.083E-3 1.034E-2
8.957E-2
 3 351
44 1269479 Downstream signal transduction BioSystems: REACTOME 1.157E-3 2.104E-3 1.045E-2
9.257E-2
 3 355
45 1269284 DAP12 signaling BioSystems: REACTOME 1.195E-3 2.125E-3 1.055E-2
9.562E-2
 3 359
46 1269380 Signaling by EGFR BioSystems: REACTOME 1.274E-3 2.216E-3 1.100E-2
1.019E-1
 3 367
47 1269283 DAP12 interactions BioSystems: REACTOME 1.346E-3 2.272E-3 1.128E-2
1.077E-1
 3 374
48 1269386 Signaling by FGFR BioSystems: REACTOME 1.376E-3 2.272E-3 1.128E-2
1.101E-1
 2 89
49 1269478 Signaling by PDGF BioSystems: REACTOME 1.398E-3 2.272E-3 1.128E-2
1.119E-1
 3 379
50 1269298 Fc epsilon receptor (FCERI) signaling BioSystems: REACTOME 1.420E-3 2.272E-3 1.128E-2
1.136E-1
 3 381
Show 45 more annotations

8: Pubmed [Display Chart] 8 input genes in category / 592 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15116392 Differential expression of Homer family proteins in the developing mouse brain. Pubmed 6.031E-12 8.927E-10 6.214E-9 3.571E-9 3 3
2 24530450 Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation. Pubmed 6.031E-12 8.927E-10 6.214E-9 3.571E-9 3 3
3 15294147 Homer proteins regulate sensitivity to cocaine. Pubmed 6.031E-12 8.927E-10 6.214E-9 3.571E-9 3 3
4 12815733 Mutation screening of the Homer gene family and association analysis in schizophrenia. Pubmed 6.031E-12 8.927E-10 6.214E-9 3.571E-9 3 3
5 12646235 Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. Pubmed 2.412E-11 1.785E-9 1.243E-8 1.428E-8 3 4
6 16979624 The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins. Pubmed 2.412E-11 1.785E-9 1.243E-8 1.428E-8 3 4
7 12860966 Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. Pubmed 2.412E-11 1.785E-9 1.243E-8 1.428E-8 3 4
8 12223488 Homer regulates gain of ryanodine receptor type 1 channel complex. Pubmed 2.412E-11 1.785E-9 1.243E-8 1.428E-8 3 4
9 22561452 Preso1 dynamically regulates group I metabotropic glutamate receptors. Pubmed 6.030E-11 3.967E-9 2.761E-8 3.570E-8 3 5
10 23911326 A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Pubmed 1.206E-10 6.490E-9 4.518E-8 7.139E-8 3 6
11 9808459 Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Pubmed 1.206E-10 6.490E-9 4.518E-8 7.139E-8 3 6
12 9808458 Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Pubmed 2.110E-10 9.609E-9 6.690E-8 1.249E-7 3 7
13 18218901 NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Pubmed 2.110E-10 9.609E-9 6.690E-8 1.249E-7 3 7
14 10493740 Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells. Pubmed 7.233E-10 3.058E-8 2.129E-7 4.282E-7 3 10
15 20934536 Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme. Pubmed 9.271E-9 3.659E-7 2.547E-6 5.489E-6 3 22
16 16959763 Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Pubmed 1.129E-8 4.179E-7 2.909E-6 6.686E-6 4 138
17 11493923 Spred is a Sprouty-related suppressor of Ras signalling. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
18 15683364 Distinct requirements for the Sprouty domain for functional activity of Spred proteins. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
19 25690936 SPREDs (Sprouty related proteins with EVH1 domain) promote self-renewal and inhibit mesodermal differentiation in murine embryonic stem cells. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
20 16314758 Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
21 12940993 Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
22 27832625 Diagnostic Potential of Differentially Expressed Homer1 and Homer2 in Ischemic Stroke. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
23 11810195 Distribution, cellular localization, and postnatal development of VASP and Mena expression in mouse tissues. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
24 17553998 Localization and expression of group I metabotropic glutamate receptors in the mouse striatum, globus pallidus, and subthalamic nucleus: regulatory effects of MPTP treatment and constitutive Homer deletion. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
25 19423641 Sprouty proteins: modified modulators, matchmakers or missing links? Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
26 16011574 Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
27 16652141 Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
28 15465815 Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
29 20333726 No association of alcohol dependence with HOMER 1 and 2 genetic variants. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
30 21885651 Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
31 12933343 Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
32 23658151 Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
33 10653696 Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing. Pubmed 3.839E-8 6.887E-7 4.795E-6 2.273E-5 2 2
34 17094949 Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
35 19435808 VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
36 14528310 PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
37 15371503 Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
38 15184877 The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
39 21364986 Sprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoids. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
40 21423205 An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
41 21398369 Biochemical analysis of the human ENA/VASP-family proteins, MENA, VASP and EVL, in homologous recombination. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
42 18387811 Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
43 23937664 Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
44 15580519 Expression and subcellular localization of Spred proteins in mouse and human tissues. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
45 19386231 Cell autonomous defects in cortical development revealed by two-color chimera analysis. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
46 10801818 Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. Pubmed 1.152E-7 1.482E-6 1.032E-5 6.818E-5 2 3
47 10069337 Mena is required for neurulation and commissure formation. Pubmed 2.303E-7 2.673E-6 1.861E-5 1.363E-4 2 4
48 19120036 A severe form of Noonan syndrome and autosomal dominant café-au-lait spots - evidence for different genetic origins. Pubmed 2.303E-7 2.673E-6 1.861E-5 1.363E-4 2 4
49 22908313 Mena binds α5 integrin directly and modulates α5β1 function. Pubmed 2.303E-7 2.673E-6 1.861E-5 1.363E-4 2 4
50 17998398 Ena/VASP is required for endothelial barrier function in vivo. Pubmed 2.303E-7 2.673E-6 1.861E-5 1.363E-4 2 4
Show 45 more annotations

9: Interaction [Display Chart] 8 input genes in category / 277 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ABI3 ABI3 interactions 1.123E-9 3.112E-7 1.930E-6 3.112E-7 4 37
2 int:FAT1 FAT1 interactions 2.771E-9 3.838E-7 2.381E-6 7.676E-7 4 46
3 int:RYR1 RYR1 interactions 2.749E-8 2.538E-6 1.574E-5 7.615E-6 3 15
4 int:HOMER2 HOMER2 interactions 1.387E-7 8.682E-6 5.386E-5 3.841E-5 3 25
5 int:GRM5 GRM5 interactions 1.567E-7 8.682E-6 5.386E-5 4.341E-5 3 26
6 int:GRM1 GRM1 interactions 9.731E-7 4.492E-5 2.787E-4 2.695E-4 3 47
7 int:ITPR1 ITPR1 interactions 2.048E-6 7.456E-5 4.625E-4 5.673E-4 3 60
8 int:IFT57 IFT57 interactions 2.153E-6 7.456E-5 4.625E-4 5.965E-4 3 61
9 int:HOMER3 HOMER3 interactions 2.491E-6 7.667E-5 4.756E-4 6.901E-4 3 64
10 int:XIRP1 XIRP1 interactions 4.997E-6 1.384E-4 8.586E-4 1.384E-3 2 8
11 int:ABI1 ABI1 interactions 5.880E-6 1.481E-4 9.184E-4 1.629E-3 3 85
12 int:HOMER1 HOMER1 interactions 6.754E-6 1.559E-4 9.671E-4 1.871E-3 3 89
13 int:ABI2 ABI2 interactions 1.313E-5 2.798E-4 1.736E-3 3.637E-3 3 111
14 int:TESK1 TESK1 interactions 1.622E-5 3.209E-4 1.990E-3 4.492E-3 2 14
15 int:RAPH1 RAPH1 interactions 3.044E-5 5.621E-4 3.487E-3 8.432E-3 2 19
16 int:TRPC1 TRPC1 interactions 4.109E-5 6.696E-4 4.153E-3 1.138E-2 2 22
17 int:TRPC5 TRPC5 interactions 4.109E-5 6.696E-4 4.153E-3 1.138E-2 2 22
18 int:SHANK3 SHANK3 interactions 4.380E-5 6.741E-4 4.181E-3 1.213E-2 3 166
19 int:FYB1 FYB1 interactions 5.333E-5 7.775E-4 4.823E-3 1.477E-2 2 25
20 int:FRYL FRYL interactions 5.776E-5 8.000E-4 4.962E-3 1.600E-2 2 26
21 int:AGAP2 AGAP2 interactions 6.862E-5 9.052E-4 5.615E-3 1.901E-2 3 193
22 int:DNMBP DNMBP interactions 7.724E-5 9.726E-4 6.033E-3 2.140E-2 2 30
23 int:GPHN GPHN interactions 1.382E-4 1.627E-3 1.009E-2 3.828E-2 2 40
24 int:ZDHHC17 ZDHHC17 interactions 1.410E-4 1.627E-3 1.009E-2 3.905E-2 3 246
25 int:DBN1 DBN1 interactions 1.514E-4 1.678E-3 1.041E-2 4.194E-2 3 252
26 int:TRIM9 TRIM9 interactions 1.831E-4 1.951E-3 1.210E-2
5.072E-2
 2 46
27 int:XPO6 XPO6 interactions 1.912E-4 1.962E-3 1.217E-2
5.297E-2
 2 47
28 int:EVL EVL interactions 2.253E-4 2.229E-3 1.383E-2
6.242E-2
 2 51
29 int:PDE4DIP PDE4DIP interactions 2.387E-4 2.280E-3 1.414E-2
6.611E-2
 3 294
30 int:CSPP1 CSPP1 interactions 2.527E-4 2.334E-3 1.447E-2
7.001E-2
 2 54
31 int:SPTA1 SPTA1 interactions 3.334E-4 2.979E-3 1.848E-2
9.234E-2
 2 62
32 int:NUP54 NUP54 interactions 3.664E-4 3.172E-3 1.968E-2
1.015E-1
 2 65
33 int:ENAH ENAH interactions 3.893E-4 3.268E-3 2.027E-2
1.078E-1
 2 67
34 int:PFN2 PFN2 interactions 4.129E-4 3.364E-3 2.087E-2
1.144E-1
 2 69
35 int:KIT KIT interactions 5.008E-4 3.964E-3 2.459E-2
1.387E-1
 2 76
36 int:WAS WAS interactions 5.275E-4 4.059E-3 2.518E-2
1.461E-1
 2 78
37 int:TACC3 TACC3 interactions 5.828E-4 4.363E-3 2.707E-2
1.614E-1
 2 82
38 int:CYFIP2 CYFIP2 interactions 7.650E-4 5.433E-3 3.370E-2
2.119E-1
 2 94
39 int:PFN1 PFN1 interactions 7.650E-4 5.433E-3 3.370E-2
2.119E-1
 2 94
40 int:APBB1 APBB1 interactions 8.311E-4 5.755E-3 3.570E-2
2.302E-1
 2 98
41 int:VASP VASP interactions 8.824E-4 5.960E-3 3.697E-2
2.444E-1
 2 101
42 int:SPRED3 SPRED3 interactions 9.036E-4 5.960E-3 3.697E-2
2.503E-1
 1 2
43 int:ZYX ZYX interactions 1.103E-3 7.104E-3 4.407E-2
3.055E-1
 2 113
44 int:VCL VCL interactions 1.368E-3 8.614E-3
5.343E-2
3.790E-1
 2 126
45 int:FGFR1OP FGFR1OP interactions 1.982E-3 1.220E-2
7.569E-2
5.491E-1
 2 152
46 int:TRPC2 TRPC2 interactions 2.258E-3 1.360E-2
8.433E-2
6.254E-1
 1 5
47 int:DLGAP1 DLGAP1 interactions 2.386E-3 1.406E-2
8.723E-2
6.610E-1
 2 167
48 int:PLCB4 PLCB4 interactions 2.709E-3 1.471E-2
9.126E-2
7.503E-1
 1 6
49 int:PCARE PCARE interactions 2.709E-3 1.471E-2
9.126E-2
7.503E-1
 1 6
50 int:CNTN4 CNTN4 interactions 2.709E-3 1.471E-2
9.126E-2
7.503E-1
 1 6
Show 45 more annotations

10: Cytoband [Display Chart] 8 input genes in category / 8 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5q14.2 5q14.2 2.306E-3 1.106E-2 3.006E-2 1.845E-2 1 10
2 15q24.3 15q24.3 3.227E-3 1.106E-2 3.006E-2 2.582E-2 1 14
3 1q42.12 1q42.12 4.147E-3 1.106E-2 3.006E-2 3.318E-2 1 18
4 19q13 19q13 7.821E-3 1.325E-2 3.601E-2
6.257E-2
 1 34
5 2p14 2p14 8.280E-3 1.325E-2 3.601E-2
6.624E-2
 1 36
6 15q14 15q14 1.194E-2 1.592E-2 4.327E-2
9.552E-2
 1 52
7 19p13.11 19p13.11 1.764E-2 1.809E-2 4.917E-2
1.411E-1
 1 77
8 19q13.32 19q13.32 1.809E-2 1.809E-2 4.917E-2
1.447E-1
 1 79
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 81 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 KMCATNNWGGA UNKNOWN KMCATNNWGGA UNKNOWN 1.068E-3 4.952E-2
2.465E-1
8.651E-2
 2 71
2 ATGGYGGA UNKNOWN ATGGYGGA UNKNOWN 1.223E-3 4.952E-2
2.465E-1
9.905E-2
 2 76

12: Gene Family [Display Chart] 6 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 871 Homer scaffolding proteins genenames.org 1.993E-11 5.978E-11 1.096E-10 5.978E-11 3 3
2 946 ENAH/VASPs genenames.org 2.719E-7 4.078E-7 7.476E-7 8.156E-7 2 3

13: Coexpression [Display Chart] 8 input genes in category / 876 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16488994-SuppTable1b Mouse Lung Lu06 856genes Array MEO430Av2 GeneSigDB 8.733E-6 4.034E-3 2.966E-2 7.650E-3 4 443
2 16488994-SuppTable1a Mouse Lung Lu06 856genes Array MG U74Av2 GeneSigDB 9.209E-6 4.034E-3 2.966E-2 8.067E-3 4 449
3 M8569 Genes up-regulated in Th1 cells 15 days post polarization: control versus stimulated with anti-CD3 and anti-CD28. MSigDB C7: Immunologic Signatures (v6.0) 3.451E-5 1.008E-2
7.410E-2
 3.023E-2 3 200
4 M1684 Genes down-regulated upon skin specific knockout of FOS [GeneID=2353] by cre-lox in the K5-SOS-F mice (express a constitutively active form of SOS1 [GeneID=6654] in the skin). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.884E-5 1.727E-2
1.270E-1
6.906E-2
 3 264
5 19717424-SuppTable1 Mouse Breast Wertheim09 110genes GeneSigDB 2.287E-4 3.455E-2
2.541E-1
2.004E-1
 2 67
6 M2466 Genes with DNA sequences bound by RARA and RARG [GeneID=5914, 5916] in ES cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.111E-4 3.455E-2
2.541E-1
3.601E-1
 3 462
7 18378853-TableS2 Human Leukemia Langer08 138genes GeneSigDB 4.596E-4 3.455E-2
2.541E-1
4.027E-1
 2 95
8 M13984 Genes up-regulated by IL2 [GeneID=3558] in cells derived from CD4+ [GeneID=920] cutaneous T-cell lymphoma (CTCL). MSigDB C2: CGP Curated Gene Sets (v6.0) 6.725E-4 3.455E-2
2.541E-1
5.891E-1
 2 115
9 12738660-TableS2 Human Leukemia Yagi03 135genes GeneSigDB 7.440E-4 3.455E-2
2.541E-1
6.518E-1
 2 121
10 M18887 Genes differentially expressed in pediatric AML (acute myeloid leukemia) samples from patients with good survival (>3 years without relapse) compared to those with poor survival (relapsed within one year after treatment). MSigDB C2: CGP Curated Gene Sets (v6.0) 8.320E-4 3.455E-2
2.541E-1
7.288E-1
 2 128
11 M1131 Genes up-regulated during skin tumor progression: epidermis treated with the carcinogen DMBA [PubChem=6001] followed by 20 weekly applications of the tumor promoter TPA [PubChem=4792], compared to the untreated skin. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.022E-3 3.455E-2
2.541E-1
8.955E-1
 2 142
12 M1135 Genes up-regulated during skin tumor progression from normal skin to high risk papilloma. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.095E-3 3.455E-2
2.541E-1
9.590E-1
 2 147
13 M366 Up-regulated genes from the 324 genes identified by two analytical methods as changed in the mammary tumors induced by transgenic expression of ERBB2 [GeneID=2064]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.140E-3 3.455E-2
2.541E-1
9.982E-1
 2 150
14 M1133 Genes up-regulated during skin tumor progression from low risk papilloma vs normal skin. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.327E-3 3.455E-2
2.541E-1
1.000E0
 2 162
15 M8590 Genes up-regulated in macrophages versus dendritic cells. MSigDB C7: Immunologic Signatures (v6.0) 1.327E-3 3.455E-2
2.541E-1
1.000E0
 2 162
16 M8729 Genes whose expression peaked at 480 min after stimulation of HeLa cells with EGF [GeneID=1950]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.360E-3 3.455E-2
2.541E-1
1.000E0
 2 164
17 M8248 Genes up-regulated in T reg: HDAC6 [GeneID=10013] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.393E-3 3.455E-2
2.541E-1
1.000E0
 2 166
18 M11585 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.546E-3 3.455E-2
2.541E-1
1.000E0
 2 175
19 M6064 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (6h) versus untreated (6h). MSigDB C7: Immunologic Signatures (v6.0) 1.914E-3 3.455E-2
2.541E-1
1.000E0
 2 195
20 M9881 Genes up-regulated in activated CD4 [GeneID=920] T cells: NRAS [GeneID=4893] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.972E-3 3.455E-2
2.541E-1
1.000E0
 2 198
21 M6119 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL4 [GeneID=3565] (6h) versus untreated (6h). MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.455E-2
2.541E-1
1.000E0
 2 199
22 M7649 Genes up-regulated in arthritic (KRN model) CD4 [GeneID=920] T cells: germ free versus specific pathogen free conditions. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.455E-2
2.541E-1
1.000E0
 2 199
23 M6953 Genes up-regulated in plasmacytoit dendritic cells (4h): untreated versus CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.455E-2
2.541E-1
1.000E0
 2 199
24 M9921 Genes up-regulated in B lymphocytes: wildtype versus MAP3K7 [GeneID=6885]. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.455E-2
2.541E-1
1.000E0
 2 199
25 M8425 Genes up-regulated in B lymphocytes: systemic lupus erythematosous (SLE) versus healthy. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.455E-2
2.541E-1
1.000E0
 2 199
26 M9807 Genes up-regulated in at day 0 B cell IRF4-KO versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4-KO. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
27 M5453 Genes up-regulated in comparison of mast cells versus Th1 cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
28 M4889 Genes down-regulated in comparison of follicular B cells versus late germinal center (GC) B cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
29 M7478 Genes up-regulated in periperal blood monocytes (PBMC) from kidney transplant recipients: tolerant versus immunosuppressive therapy. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
30 M6938 Genes down-regulated in B lymphocytes: CpG oligodeoxynucleotide 1826 versus PL2-3 (Chromatin IC). MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
31 M7644 Genes down-regulated in healthy CD4 [GeneID=920] T cells: germ free versus specific pathogen free. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
32 M3504 Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 120 min. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
33 M6062 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (6h) versus IL4 [GeneID=3565] (6h). MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
34 M3153 Genes up-regulated in comparison of T follicular helper (Tfh) cells versus Th2 cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
35 M7426 Genes down-regulated in the mature neuron cell line: control versus infected with western equine encephalitis virus. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
36 M8631 Genes down-regulated in bone marrow-derived dendritic cells: high dose of 1,3-beta-D-oligoglucan [PubChem=11375554] versus CSF2 [GeneID=1437] and high dose of 1,3-beta-D-oligoglucan [PubChem=11375554]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
37 M9851 Genes down-regulated in CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4intermediate versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell wildtype. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
38 M6935 Genes down-regulated in B lymphocytes: anti IgM versus anti IgM and CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
39 M4202 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 72 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
40 M7740 Genes down-regulated in macrophages: wildtype versus NR3C2 [GeneID=4306] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
41 M6480 Genes up-regulated in monocyte-derived dendritic cells: untreated versus LPS (3h). MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
42 M4471 Genes up-regulated in comparison of dendritic cells (DC) versus monocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
43 M8558 Genes down-regulated in effector CD8 T cells: CXCR1+ [GeneID=3577] versus CXCR1- [GeneID=3577]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
44 M7646 Genes down-regulated in CD4 [GeneID=920] T cells under germ free conditions: healthy versus arthritis (KRN model). MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
45 M6955 Genes up-regulated in plasmacytoid dendritic cells (4h): untreated versus influenza virus infection. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
46 M4194 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
47 M8733 Genes up-regulated in STAT5 double knock-in T cells: control versus IL2 [GeneID=3558] stimulation for 2h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
48 M8310 Genes up-regulated in naïve T cells: CD4 [GeneID=920] versus NK. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
49 M4705 Genes down-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 8 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
50 M9262 Genes down-regulated in CXCR5+ BCL6+ [GeneID=643;604] follicular helper T cells versus CXCR5- BCL6- CD4+ [GeneID=643;604;920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.455E-2
2.541E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 8 input genes in category / 522 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Lobular Carcinoma/4/4 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Lobular Carcinoma/4/4 TCGA-Breast 2.107E-5 1.100E-2
7.517E-2
 1.100E-2 3 160

15: Computational [Display Chart] 6 input genes in category / 20 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 8 input genes in category / 509 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-223:PITA hsa-miR-223:PITA TOP PITA 1.786E-6 9.091E-4 6.191E-3 9.091E-4 3 231
2 hsa-miR-217:TargetScan hsa-miR-217 TargetScan 4.877E-6 1.241E-3 8.454E-3 2.483E-3 3 323
3 hsa-miR-375:Functional MTI Functional MTI miRTarbase 1.563E-5 2.652E-3 1.806E-2 7.956E-3 3 477
4 hsa-miR-103a-2-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.462E-5 3.765E-3 2.564E-2 1.762E-2 2 81
5 hsa-miR-938:PITA hsa-miR-938:PITA TOP PITA 5.073E-5 3.765E-3 2.564E-2 2.582E-2 2 98
6 hsa-miR-4291:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.073E-5 3.765E-3 2.564E-2 2.582E-2 2 98
7 ATAGGAA,MIR-202:MSigDB ATAGGAA,MIR-202:MSigDB MSigDB 5.178E-5 3.765E-3 2.564E-2 2.635E-2 2 99
8 AGGAAGC,MIR-516-3P:MSigDB AGGAAGC,MIR-516-3P:MSigDB MSigDB 5.937E-5 3.778E-3 2.573E-2 3.022E-2 2 106
9 hsa-miR-508-3p:PITA hsa-miR-508-3p:PITA TOP PITA 1.081E-4 4.782E-3 3.257E-2
5.502E-2
 2 143
10 hsa-miR-1256:PITA hsa-miR-1256:PITA TOP PITA 1.142E-4 4.782E-3 3.257E-2
5.814E-2
 2 147
11 hsa-miR-3619-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.189E-4 4.782E-3 3.257E-2
6.054E-2
 2 150
12 hsa-miR-761:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.221E-4 4.782E-3 3.257E-2
6.216E-2
 2 152
13 hsa-miR-512-5p:PITA hsa-miR-512-5p:PITA TOP PITA 1.221E-4 4.782E-3 3.257E-2
6.216E-2
 2 152
14 hsa-miR-922:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.370E-4 4.981E-3 3.392E-2
6.973E-2
 2 161
15 hsa-miR-1826:PITA hsa-miR-1826:PITA TOP PITA 2.049E-4 5.702E-3 3.883E-2
1.043E-1
 2 197
16 hsa-miR-8063:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.049E-4 5.702E-3 3.883E-2
1.043E-1
 2 197
17 hsa-miR-376a:PITA hsa-miR-376a:PITA TOP PITA 2.219E-4 5.702E-3 3.883E-2
1.129E-1
 2 205
18 hsa-miR-376b:PITA hsa-miR-376b:PITA TOP PITA 2.219E-4 5.702E-3 3.883E-2
1.129E-1
 2 205
19 hsa-miR-202-5p:TargetScan hsa-miR-202-5p TargetScan 2.219E-4 5.702E-3 3.883E-2
1.129E-1
 2 205
20 hsa-miR-214-3p:Functional MTI Functional MTI miRTarbase 2.240E-4 5.702E-3 3.883E-2
1.140E-1
 2 206
21 hsa-miR-649:PITA hsa-miR-649:PITA TOP PITA 2.395E-4 5.804E-3 3.953E-2
1.219E-1
 2 213
22 hsa-miR-31-5p:Functional MTI Functional MTI miRTarbase 2.647E-4 6.122E-3 4.170E-2
1.347E-1
 2 224
23 hsa-miR-31:PITA hsa-miR-31:PITA TOP PITA 2.766E-4 6.122E-3 4.170E-2
1.408E-1
 2 229
24 CAGCTTT,MIR-320:MSigDB CAGCTTT,MIR-320:MSigDB MSigDB 3.037E-4 6.441E-3 4.387E-2
1.546E-1
 2 240
25 hsa-miR-1303:PITA hsa-miR-1303:PITA TOP PITA 3.535E-4 6.973E-3 4.749E-2
1.799E-1
 2 259
26 hsa-miR-513a-5p:PITA hsa-miR-513a-5p:PITA TOP PITA 3.562E-4 6.973E-3 4.749E-2
1.813E-1
 2 260
27 hsa-miR-183:PITA hsa-miR-183:PITA TOP PITA 3.699E-4 6.974E-3 4.750E-2
1.883E-1
 2 265
28 hsa-miR-4282:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.517E-4 7.751E-3
5.279E-2
2.299E-1
 2 293
29 ATGTACA,MIR-493:MSigDB ATGTACA,MIR-493:MSigDB MSigDB 4.548E-4 7.751E-3
5.279E-2
2.315E-1
 2 294
30 hsa-miR-653:PITA hsa-miR-653:PITA TOP PITA 4.924E-4 7.751E-3
5.279E-2
2.506E-1
 2 306
31 hsa-miR-454*:mirSVR highEffct hsa-miR-454*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.020E-4 7.751E-3
5.279E-2
2.555E-1
 2 309
32 hsa-miR-139-5p:TargetScan hsa-miR-139-5p TargetScan 5.216E-4 7.751E-3
5.279E-2
2.655E-1
 2 315
33 hsa-miR-6832-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.249E-4 7.751E-3
5.279E-2
2.672E-1
 2 316
34 hsa-miR-139-5p:PITA hsa-miR-139-5p:PITA TOP PITA 5.348E-4 7.751E-3
5.279E-2
2.722E-1
 2 319
35 hsa-miR-217:PITA hsa-miR-217:PITA TOP PITA 5.348E-4 7.751E-3
5.279E-2
2.722E-1
 2 319
36 hsa-miR-513b:PITA hsa-miR-513b:PITA TOP PITA 5.482E-4 7.751E-3
5.279E-2
2.790E-1
 2 323
37 hsa-miR-211-5p:Functional MTI Functional MTI miRTarbase 5.859E-4 7.829E-3
5.332E-2
2.982E-1
 2 334
38 hsa-miR-212:PITA hsa-miR-212:PITA TOP PITA 5.999E-4 7.829E-3
5.332E-2
3.053E-1
 2 338
39 hsa-miR-132:PITA hsa-miR-132:PITA TOP PITA 5.999E-4 7.829E-3
5.332E-2
3.053E-1
 2 338
40 hsa-miR-1200:PITA hsa-miR-1200:PITA TOP PITA 6.429E-4 8.180E-3
5.571E-2
3.272E-1
 2 350
41 hsa-miR-768-3p:PITA hsa-miR-768-3p:PITA TOP PITA 6.761E-4 8.206E-3
5.589E-2
3.441E-1
 2 359
42 AAGCACA,MIR-218:MSigDB AAGCACA,MIR-218:MSigDB MSigDB 7.177E-4 8.206E-3
5.589E-2
3.653E-1
 2 370
43 hsa-miR-1:PITA hsa-miR-1:PITA TOP PITA 7.216E-4 8.206E-3
5.589E-2
3.673E-1
 2 371
44 hsa-miR-206:PITA hsa-miR-206:PITA TOP PITA 7.216E-4 8.206E-3
5.589E-2
3.673E-1
 2 371
45 hsa-miR-613:PITA hsa-miR-613:PITA TOP PITA 7.255E-4 8.206E-3
5.589E-2
3.693E-1
 2 372
46 hsa-miR-204-5p:Functional MTI Functional MTI miRTarbase 8.335E-4 9.223E-3
6.281E-2
4.242E-1
 2 399
47 hsa-miR-204:PITA hsa-miR-204:PITA TOP PITA 9.710E-4 1.030E-2
7.013E-2
4.942E-1
 2 431
48 hsa-miR-211:PITA hsa-miR-211:PITA TOP PITA 9.710E-4 1.030E-2
7.013E-2
4.942E-1
 2 431
49 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 1.002E-3 1.039E-2
7.076E-2
5.102E-1
 2 438
50 hsa-miR-544:PITA hsa-miR-544:PITA TOP PITA 1.021E-3 1.039E-2
7.076E-2
5.195E-1
 2 442
Show 45 more annotations

17: Drug [Display Chart] 8 input genes in category / 2202 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID005288160 etheno-NAD Stitch 2.799E-8 6.164E-5 5.100E-4 6.164E-5 4 104
2 CID002723790 thiourea Stitch 9.431E-6 1.038E-2
8.592E-2
 2.077E-2 3 128
3 CID000005114 3-(1H-pyrrole-2-carboxylate Stitch 5.651E-5 4.148E-2
3.432E-1
1.244E-1
 3 233
4 CID006324636 LY341495 Stitch 9.624E-5 4.498E-2
3.722E-1
2.119E-1
 2 43
5 CID003025961 MPEP Stitch 1.818E-4 4.498E-2
3.722E-1
4.004E-1
 2 59
6 ctd:C079148 (3-aminopropyl)(n-butyl)phosphinic acid CTD 3.502E-4 4.498E-2
3.722E-1
7.712E-1
 1 1
7 CID000128346 mDia Stitch 4.520E-4 4.498E-2
3.722E-1
9.952E-1
 2 93
8 CID000001310 1-aminocyclopentane-1,3-dicarboxylate Stitch 6.429E-4 4.498E-2
3.722E-1
1.000E0
 2 111
9 CID000137860 U239 Stitch 7.004E-4 4.498E-2
3.722E-1
1.000E0
 1 2
10 CID000213037 HMR1766 Stitch 7.004E-4 4.498E-2
3.722E-1
1.000E0
 1 2
11 CID000001541 2-arachidonoylglycerol (2-AG Stitch 7.384E-4 4.498E-2
3.722E-1
1.000E0
 2 119
12 CID000120739 G 3012 Stitch 9.072E-4 4.498E-2
3.722E-1
1.000E0
 2 132
13 CID000003454 ganciclovir Stitch 1.019E-3 4.498E-2
3.722E-1
1.000E0
 2 140
14 ctd:C071644 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate CTD 1.050E-3 4.498E-2
3.722E-1
1.000E0
 1 3
15 CID000069114 Es-6 Stitch 1.050E-3 4.498E-2
3.722E-1
1.000E0
 1 3
16 CID004369374 AC1N9ZZC Stitch 1.153E-3 4.498E-2
3.722E-1
1.000E0
 2 149
17 ctd:D010098 Oxycodone CTD 1.263E-3 4.498E-2
3.722E-1
1.000E0
 2 156
18 4985 UP Lasalocid sodium salt [25999-20-6]; Up 200; 6.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.395E-3 4.498E-2
3.722E-1
1.000E0
 2 164
19 CID009982357 CHEMBL14407 Stitch 1.400E-3 4.498E-2
3.722E-1
1.000E0
 1 4
20 ctd:D036563 Cyclic ADP-Ribose CTD 1.400E-3 4.498E-2
3.722E-1
1.000E0
 1 4
21 1152 DN retinoic acid; Down 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.676E-3 4.498E-2
3.722E-1
1.000E0
 2 180
22 ctd:C503978 MRS 1845 CTD 1.750E-3 4.498E-2
3.722E-1
1.000E0
 1 5
23 ctd:D010417 Pentaerythritol Tetranitrate CTD 1.750E-3 4.498E-2
3.722E-1
1.000E0
 1 5
24 CID000150933 pentaerythritol mononitrate Stitch 1.750E-3 4.498E-2
3.722E-1
1.000E0
 1 5
25 CID006420160 2f34 Stitch 1.826E-3 4.498E-2
3.722E-1
1.000E0
 2 188
26 1974 DN Pyrimethamine [58-14-0]; Down 200; 16uM; HL60; HG-U133A Broad Institute CMAP Down 1.865E-3 4.498E-2
3.722E-1
1.000E0
 2 190
27 1056 DN 17-AAG; Down 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.865E-3 4.498E-2
3.722E-1
1.000E0
 2 190
28 430 UP rosiglitazone maleate; Up 200; 10uM; PC3; HG-U133A Broad Institute CMAP Up 1.884E-3 4.498E-2
3.722E-1
1.000E0
 2 191
29 2078 DN Triamcinolone [124-94-7]; Down 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.904E-3 4.498E-2
3.722E-1
1.000E0
 2 192
30 4431 DN Rapamycin; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.923E-3 4.498E-2
3.722E-1
1.000E0
 2 193
31 6981 DN Rapamycin; Down 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.923E-3 4.498E-2
3.722E-1
1.000E0
 2 193
32 5989 DN Trichlorfon [52-68-6]; Down 200; 15.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.923E-3 4.498E-2
3.722E-1
1.000E0
 2 193
33 7364 DN Dilazep dihydrochloride [20153-98-4]; Down 200; 6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.923E-3 4.498E-2
3.722E-1
1.000E0
 2 193
34 1957 DN Methotrexate [59-05-2]; Down 200; 8.8uM; PC3; HG-U133A Broad Institute CMAP Down 1.923E-3 4.498E-2
3.722E-1
1.000E0
 2 193
35 3799 DN Parbendazole [14255-87-9]; Down 200; 16.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.923E-3 4.498E-2
3.722E-1
1.000E0
 2 193
36 2965 UP Iopanoic acid [96-83-3]; Up 200; 7uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.943E-3 4.498E-2
3.722E-1
1.000E0
 2 194
37 361 DN LY294002; Down 200; 10uM; HL60; HG-U133A Broad Institute CMAP Down 1.943E-3 4.498E-2
3.722E-1
1.000E0
 2 194
38 952 DN carbamazepine; Down 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.943E-3 4.498E-2
3.722E-1
1.000E0
 2 194
39 7044 UP GSK-3 Inhibitor IX; Up 200; 0.5uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.943E-3 4.498E-2
3.722E-1
1.000E0
 2 194
40 900 UP 5186324; Up 200; 2uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 1.963E-3 4.498E-2
3.722E-1
1.000E0
 2 195
41 ctd:D006710 Homocysteine CTD 1.963E-3 4.498E-2
3.722E-1
1.000E0
 2 195
42 6754 DN Fusidic acid sodium salt [751-94-0]; Down 200; 7.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.963E-3 4.498E-2
3.722E-1
1.000E0
 2 195
43 7362 DN Tiapride hydrochloride [51012-33-0]; Down 200; 11uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.963E-3 4.498E-2
3.722E-1
1.000E0
 2 195
44 3864 DN Ethisterone [434-03-7]; Down 200; 12.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.963E-3 4.498E-2
3.722E-1
1.000E0
 2 195
45 3078 UP Urapidil hydrochloride [64887-14-5]; Up 200; 9.4uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.963E-3 4.498E-2
3.722E-1
1.000E0
 2 195
46 5115 UP Metampicillin sodium salt [6489-61-8]; Up 200; 10.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.983E-3 4.498E-2
3.722E-1
1.000E0
 2 196
47 5111 UP Scoulerine [6451-73-6]; Up 200; 12.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.983E-3 4.498E-2
3.722E-1
1.000E0
 2 196
48 6748 DN Bisoprolol fumarate; Down 200; 9uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.983E-3 4.498E-2
3.722E-1
1.000E0
 2 196
49 5052 DN Allantoin [97-59-6]; Down 200; 25.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.983E-3 4.498E-2
3.722E-1
1.000E0
 2 196
50 5409 DN Dinoprost trometamol [38362-01-5]; Down 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.983E-3 4.498E-2
3.722E-1
1.000E0
 2 196
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 51 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 cv:C1969623 Legius syndrome Clinical Variations 4.320E-4 7.343E-3 3.318E-2 2.203E-2 1 1
2 C4225240 DEAFNESS, AUTOSOMAL DOMINANT 68 DisGeNET Curated 4.320E-4 7.343E-3 3.318E-2 2.203E-2 1 1
3 OMIN:611431 LEGIUS SYNDROME OMIM 4.320E-4 7.343E-3 3.318E-2 2.203E-2 1 1
4 C0796000 Multiple non-ossifying fibromatosis DisGeNET BeFree 8.638E-4 9.223E-3 4.168E-2 4.405E-2 1 2
5 C0236736 Cocaine-Related Disorders DisGeNET Curated 9.042E-4 9.223E-3 4.168E-2 4.612E-2 2 108
6 20081125:Sanna Height GWAS 2.158E-3 1.572E-2
7.105E-2
1.101E-1
 1 5
7 C1969623 NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME DisGeNET Curated 2.158E-3 1.572E-2
7.105E-2
1.101E-1
 1 5
8 C0233488 Feeling despair DisGeNET BeFree 3.020E-3 1.926E-2
8.701E-2
1.540E-1
 1 7
9 C0013386 Dyskinesia, Drug-Induced DisGeNET Curated 7.322E-3 4.149E-2
1.875E-1
3.734E-1
 1 17
10 C3272363 Ischemic Cerebrovascular Accident DisGeNET BeFree 8.597E-3 4.256E-2
1.923E-1
4.384E-1
 2 340
11 C0237123 Alcohol or Other Drugs use DisGeNET Curated 9.895E-3 4.256E-2
1.923E-1
5.046E-1
 1 23
12 C0948008 Ischemic stroke DisGeNET Curated 1.001E-2 4.256E-2
1.923E-1
5.107E-1
 2 368
13 C0001080 Achondroplasia DisGeNET Curated 1.118E-2 4.384E-2
1.981E-1
5.701E-1
 1 26
14 C0038354 Stomach Diseases DisGeNET Curated 1.203E-2 4.384E-2
1.981E-1
6.138E-1
 1 28
Show 9 more annotations