Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc23_13, positive side

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1: GO: Molecular Function [Display Chart] 13 input genes in category / 106 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003684 damaged DNA binding 2.996E-20 3.175E-18 1.666E-17 3.175E-18 9 65
2 GO:0032404 mismatch repair complex binding 3.820E-15 2.024E-13 1.062E-12 4.049E-13 5 8
3 GO:0004519 endonuclease activity 4.306E-14 1.521E-12 7.980E-12 4.564E-12 8 167
4 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1.363E-13 3.610E-12 1.893E-11 1.444E-11 5 14
5 GO:0097506 deaminated base DNA N-glycosylase activity 2.043E-13 3.610E-12 1.893E-11 2.166E-11 5 15
6 GO:0004844 uracil DNA N-glycosylase activity 2.043E-13 3.610E-12 1.893E-11 2.166E-11 5 15
7 GO:0004518 nuclease activity 5.755E-13 7.716E-12 4.047E-11 6.100E-11 8 230
8 GO:0019104 DNA N-glycosylase activity 5.823E-13 7.716E-12 4.047E-11 6.173E-11 5 18
9 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3.602E-12 4.242E-11 2.225E-10 3.818E-10 5 25
10 GO:0004520 endodeoxyribonuclease activity 2.317E-11 2.457E-10 1.289E-9 2.457E-9 6 94
11 GO:0017065 single-strand selective uracil DNA N-glycosylase activity 4.659E-11 3.527E-10 1.850E-9 4.938E-9 4 11
12 GO:0070636 nicotinic acid riboside hydrolase activity 4.659E-11 3.527E-10 1.850E-9 4.938E-9 4 11
13 GO:0070635 nicotinamide riboside hydrolase activity 4.659E-11 3.527E-10 1.850E-9 4.938E-9 4 11
14 GO:0070694 deoxyribonucleoside 5'-monophosphate N-glycosidase activity 4.659E-11 3.527E-10 1.850E-9 4.938E-9 4 11
15 GO:0004536 deoxyribonuclease activity 5.736E-11 3.897E-10 2.044E-9 6.080E-9 6 109
16 GO:0043733 DNA-3-methylbase glycosylase activity 6.985E-11 3.897E-10 2.044E-9 7.404E-9 4 12
17 GO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity 6.985E-11 3.897E-10 2.044E-9 7.404E-9 4 12
18 GO:0030983 mismatched DNA binding 6.985E-11 3.897E-10 2.044E-9 7.404E-9 4 12
19 GO:0003905 alkylbase DNA N-glycosylase activity 6.985E-11 3.897E-10 2.044E-9 7.404E-9 4 12
20 GO:0000700 mismatch base pair DNA N-glycosylase activity 1.009E-10 5.346E-10 2.804E-9 1.069E-8 4 13
21 GO:0032137 guanine/thymine mispair binding 1.056E-9 5.088E-9 2.669E-8 1.119E-7 3 4
22 GO:0032138 single base insertion or deletion binding 1.056E-9 5.088E-9 2.669E-8 1.119E-7 3 4
23 GO:0016835 carbon-oxygen lyase activity 2.450E-9 1.076E-8 5.643E-8 2.597E-7 5 87
24 GO:0032356 oxidized DNA binding 2.639E-9 1.076E-8 5.643E-8 2.797E-7 3 5
25 GO:0032357 oxidized purine DNA binding 2.639E-9 1.076E-8 5.643E-8 2.797E-7 3 5
26 GO:0032407 MutSalpha complex binding 2.639E-9 1.076E-8 5.643E-8 2.797E-7 3 5
27 GO:0032405 MutLalpha complex binding 5.276E-9 1.997E-8 1.048E-7 5.592E-7 3 6
28 GO:0032135 DNA insertion or deletion binding 5.276E-9 1.997E-8 1.048E-7 5.592E-7 3 6
29 GO:0016829 lyase activity 1.423E-7 5.202E-7 2.729E-6 1.509E-5 5 195
30 GO:0016798 hydrolase activity, acting on glycosyl bonds 1.916E-7 6.770E-7 3.551E-6 2.031E-5 5 207
31 GO:0032143 single thymine insertion binding 4.480E-7 1.532E-6 8.035E-6 4.749E-5 2 2
32 GO:0032142 single guanine insertion binding 1.343E-6 4.315E-6 2.264E-5 1.424E-4 2 3
33 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity 1.343E-6 4.315E-6 2.264E-5 1.424E-4 2 3
34 GO:0000702 oxidized base lesion DNA N-glycosylase activity 2.686E-6 8.134E-6 4.267E-5 2.847E-4 2 4
35 GO:0008309 double-stranded DNA exodeoxyribonuclease activity 2.686E-6 8.134E-6 4.267E-5 2.847E-4 2 4
36 GO:0004523 RNA-DNA hybrid ribonuclease activity 3.479E-5 1.024E-4 5.374E-4 3.688E-3 2 13
37 GO:0003697 single-stranded DNA binding 4.618E-5 1.323E-4 6.940E-4 4.895E-3 3 104
38 GO:0000400 four-way junction DNA binding 5.346E-5 1.491E-4 7.823E-4 5.667E-3 2 16
39 GO:0004529 exodeoxyribonuclease activity 6.811E-5 1.805E-4 9.468E-4 7.220E-3 2 18
40 GO:0016895 exodeoxyribonuclease activity, producing 5'-phosphomonoesters 6.811E-5 1.805E-4 9.468E-4 7.220E-3 2 18
41 GO:0000217 DNA secondary structure binding 1.332E-4 3.443E-4 1.806E-3 1.412E-2 2 25
42 GO:0016887 ATPase activity 1.939E-4 4.894E-4 2.567E-3 2.056E-2 4 446
43 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters 2.943E-4 7.255E-4 3.805E-3 3.119E-2 2 37
44 GO:0000287 magnesium ion binding 3.494E-4 8.336E-4 4.373E-3 3.704E-2 3 206
45 GO:0051539 4 iron, 4 sulfur cluster binding 3.618E-4 8.336E-4 4.373E-3 3.835E-2 2 41
46 GO:0043531 ADP binding 3.618E-4 8.336E-4 4.373E-3 3.835E-2 2 41
47 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4.758E-4 1.073E-3 5.629E-3
5.043E-2
 2 47
48 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4.963E-4 1.096E-3 5.749E-3
5.261E-2
 2 48
49 GO:0044824 retroviral 3' processing activity 6.281E-4 1.279E-3 6.708E-3
6.658E-2
 2 54
50 GO:0044823 retroviral integrase activity 6.281E-4 1.279E-3 6.708E-3
6.658E-2
 2 54
Show 45 more annotations

2: GO: Biological Process [Display Chart] 13 input genes in category / 408 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006284 base-excision repair 4.227E-16 1.724E-13 1.136E-12 1.724E-13 7 44
2 GO:0016446 somatic hypermutation of immunoglobulin genes 3.001E-13 5.781E-11 3.809E-10 1.225E-10 5 16
3 GO:0002566 somatic diversification of immune receptors via somatic mutation 4.250E-13 5.781E-11 3.809E-10 1.734E-10 5 17
4 GO:0006298 mismatch repair 2.215E-11 2.260E-9 1.489E-8 9.039E-9 5 35
5 GO:0006285 base-excision repair, AP site formation 2.990E-11 2.440E-9 1.608E-8 1.220E-8 4 10
6 GO:0006304 DNA modification 3.643E-11 2.477E-9 1.632E-8 1.486E-8 6 101
7 GO:0016447 somatic recombination of immunoglobulin gene segments 1.042E-10 6.075E-9 4.004E-8 4.253E-8 5 47
8 GO:0006310 DNA recombination 1.836E-10 9.361E-9 6.169E-8 7.489E-8 7 267
9 GO:0016445 somatic diversification of immunoglobulins 2.357E-10 1.069E-8 7.042E-8 9.617E-8 5 55
10 GO:0098502 DNA dephosphorylation 2.657E-10 1.084E-8 7.144E-8 1.084E-7 3 3
11 GO:0016444 somatic cell DNA recombination 3.694E-10 1.256E-8 8.276E-8 1.507E-7 5 60
12 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 3.694E-10 1.256E-8 8.276E-8 1.507E-7 5 60
13 GO:0002200 somatic diversification of immune receptors 7.577E-10 2.378E-8 1.567E-7 3.091E-7 5 69
14 GO:0051052 regulation of DNA metabolic process 1.722E-9 5.019E-8 3.307E-7 7.027E-7 7 368
15 GO:0098501 polynucleotide dephosphorylation 5.308E-9 1.444E-7 9.514E-7 2.166E-6 3 6
16 GO:0002377 immunoglobulin production 6.123E-9 1.561E-7 1.029E-6 2.498E-6 5 104
17 GO:0009314 response to radiation 1.086E-8 2.606E-7 1.717E-6 4.430E-6 7 480
18 GO:0006289 nucleotide-excision repair 1.209E-8 2.741E-7 1.806E-6 4.934E-6 5 119
19 GO:0090305 nucleic acid phosphodiester bond hydrolysis 1.447E-8 3.030E-7 1.996E-6 5.903E-6 6 272
20 GO:0045008 depyrimidination 1.485E-8 3.030E-7 1.996E-6 6.059E-6 3 8
21 GO:0009223 pyrimidine deoxyribonucleotide catabolic process 4.370E-8 8.491E-7 5.595E-6 1.783E-5 3 11
22 GO:0006244 pyrimidine nucleotide catabolic process 5.825E-8 1.080E-6 7.119E-6 2.377E-5 3 12
23 GO:0002440 production of molecular mediator of immune response 9.380E-8 1.664E-6 1.097E-5 3.827E-5 5 179
24 GO:0006302 double-strand break repair 1.475E-7 2.507E-6 1.652E-5 6.017E-5 5 196
25 GO:0045910 negative regulation of DNA recombination 2.155E-7 3.382E-6 2.229E-5 8.794E-5 3 18
26 GO:0009264 deoxyribonucleotide catabolic process 2.155E-7 3.382E-6 2.229E-5 8.794E-5 3 18
27 GO:0006979 response to oxidative stress 2.473E-7 3.599E-6 2.372E-5 1.009E-4 6 439
28 GO:0046386 deoxyribose phosphate catabolic process 2.558E-7 3.599E-6 2.372E-5 1.044E-4 3 19
29 GO:0009219 pyrimidine deoxyribonucleotide metabolic process 2.558E-7 3.599E-6 2.372E-5 1.044E-4 3 19
30 GO:0006286 base-excision repair, base-free sugar-phosphate removal 4.498E-7 6.118E-6 4.031E-5 1.835E-4 2 2
31 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 8.500E-7 1.119E-5 7.372E-5 3.468E-4 4 112
32 GO:0051053 negative regulation of DNA metabolic process 9.451E-7 1.205E-5 7.941E-5 3.856E-4 4 115
33 GO:0045007 depurination 1.349E-6 1.659E-5 1.093E-4 5.504E-4 2 3
34 GO:0007568 aging 1.383E-6 1.659E-5 1.093E-4 5.642E-4 5 308
35 GO:0072529 pyrimidine-containing compound catabolic process 1.432E-6 1.670E-5 1.100E-4 5.844E-4 3 33
36 GO:0009394 2'-deoxyribonucleotide metabolic process 1.570E-6 1.780E-5 1.173E-4 6.407E-4 3 34
37 GO:0019692 deoxyribose phosphate metabolic process 1.872E-6 2.065E-5 1.360E-4 7.639E-4 3 36
38 GO:0009262 deoxyribonucleotide metabolic process 2.394E-6 2.570E-5 1.693E-4 9.766E-4 3 39
39 GO:0045190 isotype switching 3.003E-6 2.988E-5 1.969E-4 1.225E-3 3 42
40 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 3.003E-6 2.988E-5 1.969E-4 1.225E-3 3 42
41 GO:0002208 somatic diversification of immunoglobulins involved in immune response 3.003E-6 2.988E-5 1.969E-4 1.225E-3 3 42
42 GO:0007131 reciprocal meiotic recombination 3.707E-6 3.518E-5 2.318E-4 1.513E-3 3 45
43 GO:0035825 homologous recombination 3.707E-6 3.518E-5 2.318E-4 1.513E-3 3 45
44 GO:0000710 meiotic mismatch repair 4.493E-6 4.003E-5 2.638E-4 1.833E-3 2 5
45 GO:0043570 maintenance of DNA repeat elements 4.493E-6 4.003E-5 2.638E-4 1.833E-3 2 5
46 GO:0006220 pyrimidine nucleotide metabolic process 4.513E-6 4.003E-5 2.638E-4 1.841E-3 3 48
47 GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response 6.101E-6 5.245E-5 3.456E-4 2.489E-3 3 53
48 GO:0034655 nucleobase-containing compound catabolic process 6.170E-6 5.245E-5 3.456E-4 2.517E-3 5 418
49 GO:0051096 positive regulation of helicase activity 6.737E-6 5.609E-5 3.696E-4 2.749E-3 2 6
50 GO:1903046 meiotic cell cycle process 7.741E-6 6.316E-5 4.162E-4 3.158E-3 4 195
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 13 input genes in category / 25 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0032300 mismatch repair complex 1.768E-10 4.419E-9 1.686E-8 4.419E-9 4 15
2 GO:1990391 DNA repair complex 2.089E-8 2.611E-7 9.963E-7 5.221E-7 4 46
3 GO:0032301 MutSalpha complex 4.294E-7 3.578E-6 1.365E-5 1.073E-5 2 2
4 GO:0032389 MutLalpha complex 9.000E-6 5.625E-5 2.146E-4 2.250E-4 2 7
5 GO:0000784 nuclear chromosome, telomeric region 9.025E-5 4.513E-4 1.722E-3 2.256E-3 3 133
6 GO:0000781 chromosome, telomeric region 1.619E-4 6.746E-4 2.574E-3 4.047E-3 3 162
7 GO:0000795 synaptonemal complex 3.137E-4 1.120E-3 4.275E-3 7.842E-3 2 39
8 GO:0032302 MutSbeta complex 1.364E-3 4.047E-3 1.544E-2 3.409E-2 1 2
9 GO:0098687 chromosomal region 1.457E-3 4.047E-3 1.544E-2 3.642E-2 3 344
10 GO:0000794 condensed nuclear chromosome 1.928E-3 4.819E-3 1.839E-2 4.819E-2 2 97
11 GO:0005712 chiasma 2.726E-3 6.194E-3 2.364E-2
6.814E-2
 1 4
12 GO:0016607 nuclear speck 7.995E-3 1.642E-2
6.267E-2
1.999E-1
 2 201
13 GO:0000793 condensed chromosome 8.540E-3 1.642E-2
6.267E-2
2.135E-1
 2 208
14 GO:0001673 male germ cell nucleus 1.423E-2 2.542E-2
9.698E-2
3.558E-1
 1 21
15 GO:0043073 germ cell nucleus 1.826E-2 3.044E-2
1.162E-1
4.566E-1
 1 27
16 GO:0016604 nuclear body 2.469E-2 3.857E-2
1.472E-1
6.171E-1
 2 364
Show 11 more annotations

4: Human Phenotype [Display Chart] 9 input genes in category / 263 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0012114 Endometrial carcinoma 5.567E-11 9.928E-9 6.107E-8 1.464E-8 5 18
2 HP:0030126 Abnormality of the endometrium 7.550E-11 9.928E-9 6.107E-8 1.986E-8 5 19
3 HP:0100571 Cardiac diverticulum 2.153E-10 1.888E-8 1.161E-7 5.663E-8 4 7
4 HP:0000997 Axillary freckling 1.289E-9 6.779E-8 4.170E-7 3.389E-7 4 10
5 HP:0012842 Skin appendage neoplasm 1.289E-9 6.779E-8 4.170E-7 3.389E-7 4 10
6 HP:0012113 Abnormality of creatine metabolism 2.023E-9 8.869E-8 5.456E-7 5.322E-7 4 11
7 HP:0005227 Adenomatous colonic polyposis 2.418E-9 9.086E-8 5.589E-7 6.360E-7 5 36
8 HP:0010524 Agnosia 3.033E-9 9.969E-8 6.132E-7 7.976E-7 4 12
9 HP:0006778 Benign genitourinary tract neoplasm 4.836E-9 1.060E-7 6.519E-7 1.272E-6 3 3
10 HP:0006758 Malignant genitourinary tract tumor 4.836E-9 1.060E-7 6.519E-7 1.272E-6 3 3
11 HP:0006719 Benign gastrointestinal tract tumors 4.836E-9 1.060E-7 6.519E-7 1.272E-6 3 3
12 HP:0030410 Sebaceous gland carcinoma 4.836E-9 1.060E-7 6.519E-7 1.272E-6 3 3
13 HP:0006716 Hereditary nonpolyposis colorectal carcinoma 6.927E-9 1.401E-7 8.620E-7 1.822E-6 5 44
14 HP:0030255 Large intestinal polyposis 7.787E-9 1.463E-7 8.999E-7 2.048E-6 5 45
15 HP:0100013 Neoplasm of the breast 1.523E-8 2.671E-7 1.643E-6 4.006E-6 7 221
16 HP:0012118 Laryngeal carcinoma 1.932E-8 2.990E-7 1.839E-6 5.082E-6 3 4
17 HP:0100605 Neoplasm of the larynx 1.932E-8 2.990E-7 1.839E-6 5.082E-6 3 4
18 HP:0001480 Freckling 2.894E-8 3.805E-7 2.341E-6 7.610E-6 5 58
19 HP:0006749 Malignant gastrointestinal tract tumors 2.894E-8 3.805E-7 2.341E-6 7.610E-6 5 58
20 HP:0002672 Gastrointestinal carcinoma 2.894E-8 3.805E-7 2.341E-6 7.610E-6 5 58
21 HP:0010786 Urinary tract neoplasm 3.511E-8 4.397E-7 2.705E-6 9.234E-6 7 249
22 HP:0100826 Neoplasm of the nail 4.827E-8 5.519E-7 3.395E-6 1.269E-5 3 5
23 HP:0100804 Ungual fibroma 4.827E-8 5.519E-7 3.395E-6 1.269E-5 3 5
24 HP:0200008 Intestinal polyposis 6.536E-8 7.162E-7 4.406E-6 1.719E-5 5 68
25 HP:0005266 Intestinal polyp 9.384E-8 9.755E-7 6.001E-6 2.468E-5 5 73
26 HP:0100684 Salivary gland neoplasm 9.644E-8 9.755E-7 6.001E-6 2.536E-5 3 6
27 HP:0010526 Dysgraphia 1.062E-7 1.034E-6 6.360E-6 2.792E-5 4 27
28 HP:0100743 Neoplasm of the rectum 1.237E-7 1.122E-6 6.903E-6 3.254E-5 4 28
29 HP:0002888 Ependymoma 1.237E-7 1.122E-6 6.903E-6 3.254E-5 4 28
30 HP:0040274 Adenocarcinoma of the small intestine 1.686E-7 1.430E-6 8.799E-6 4.434E-5 3 7
31 HP:0006771 Duodenal adenocarcinoma 1.686E-7 1.430E-6 8.799E-6 4.434E-5 3 7
32 HP:0007379 Neoplasm of the genitourinary tract 2.150E-7 1.726E-6 1.062E-5 5.654E-5 7 323
33 HP:0006725 Pancreatic adenocarcinoma 2.166E-7 1.726E-6 1.062E-5 5.696E-5 4 32
34 HP:0002671 Basal cell carcinoma 2.285E-7 1.768E-6 1.087E-5 6.010E-5 5 87
35 HP:0003003 Colon cancer 2.421E-7 1.819E-6 1.119E-5 6.368E-5 5 88
36 HP:0004394 Multiple gastric polyps 2.695E-7 1.969E-6 1.211E-5 7.088E-5 3 8
37 HP:0100576 Amaurosis fugax 2.788E-7 1.982E-6 1.219E-5 7.333E-5 4 34
38 HP:0010784 Uterine neoplasm 3.378E-7 2.338E-6 1.438E-5 8.884E-5 5 94
39 HP:0100273 Neoplasm of the colon 4.167E-7 2.810E-6 1.729E-5 1.096E-4 5 98
40 HP:0100649 Neoplasm of the oral cavity 4.924E-7 3.238E-6 1.992E-5 1.295E-4 4 39
41 HP:0100613 Death in early adulthood 5.467E-7 3.507E-6 2.157E-5 1.438E-4 4 40
42 HP:0040273 Adenocarcinoma of the intestines 5.764E-7 3.610E-6 2.220E-5 1.516E-4 3 10
43 HP:0003002 Breast carcinoma 6.175E-7 3.777E-6 2.323E-5 1.624E-4 6 214
44 HP:0010623 Tumours of the breast 6.349E-7 3.795E-6 2.334E-5 1.670E-4 6 215
45 HP:0009726 Renal neoplasm 6.894E-7 4.029E-6 2.478E-5 1.813E-4 6 218
46 HP:0100843 Glioblastoma 7.363E-7 4.210E-6 2.590E-5 1.936E-4 4 43
47 HP:0100834 Neoplasm of the large intestine 1.528E-6 8.549E-6 5.258E-5 4.018E-4 5 127
48 HP:0002894 Neoplasm of the pancreas 1.783E-6 9.571E-6 5.887E-5 4.690E-4 5 131
49 HP:0008775 Abnormality of the prostate 1.783E-6 9.571E-6 5.887E-5 4.690E-4 5 131
50 HP:0031093 Abnormal breast morphology 1.904E-6 1.002E-5 6.161E-5 5.008E-4 7 443
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 13 input genes in category / 513 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008058 abnormal DNA repair 2.793E-15 1.433E-12 9.769E-12 1.433E-12 9 125
2 MP:0012431 increased lymphoma incidence 1.900E-12 4.873E-10 3.323E-9 9.747E-10 9 255
3 MP:0010296 increased hemolymphoid system tumor incidence 9.574E-12 1.191E-9 8.120E-9 4.912E-9 9 305
4 MP:0010383 increased adenoma incidence 1.112E-11 1.191E-9 8.120E-9 5.702E-9 8 186
5 MP:0020189 abnormal adenoma incidence 1.161E-11 1.191E-9 8.120E-9 5.954E-9 8 187
6 MP:0002048 increased lung adenoma incidence 4.385E-11 3.569E-9 2.433E-8 2.250E-8 6 59
7 MP:0020190 abnormal lung adenoma incidence 4.869E-11 3.569E-9 2.433E-8 2.498E-8 6 60
8 MP:0008014 increased lung tumor incidence 1.770E-10 1.009E-8 6.881E-8 9.082E-8 7 149
9 MP:0010298 increased respiratory system tumor incidence 1.770E-10 1.009E-8 6.881E-8 9.082E-8 7 149
10 MP:0009308 increased adenocarcinoma incidence 6.450E-10 3.309E-8 2.256E-7 3.309E-7 7 179
11 MP:0002038 increased carcinoma incidence 7.961E-10 3.713E-8 2.532E-7 4.084E-7 8 317
12 MP:0010287 increased reproductive system tumor incidence 1.914E-9 8.183E-8 5.579E-7 9.819E-7 6 109
13 MP:0002018 increased malignant tumor incidence 4.371E-9 1.725E-7 1.176E-6 2.242E-6 8 393
14 MP:0010288 increased gland tumor incidence 1.913E-8 7.010E-7 4.780E-6 9.814E-6 7 291
15 MP:0010365 increased thymus tumor incidence 1.175E-7 3.902E-6 2.660E-5 6.029E-5 5 105
16 MP:0008714 increased lung carcinoma incidence 1.292E-7 3.902E-6 2.660E-5 6.629E-5 5 107
17 MP:0009797 abnormal mismatch repair 1.293E-7 3.902E-6 2.660E-5 6.633E-5 3 9
18 MP:0010279 increased gastrointestinal tumor incidence 2.707E-7 7.715E-6 5.260E-5 1.389E-4 5 124
19 MP:0010292 increased alimentary system tumor incidence 4.961E-7 1.340E-5 9.134E-5 2.545E-4 5 140
20 MP:0002404 increased intestinal adenoma incidence 1.234E-6 3.165E-5 2.158E-4 6.330E-4 4 69
21 MP:0009590 increased gonad tumor incidence 1.465E-6 3.579E-5 2.441E-4 7.517E-4 4 72
22 MP:0002027 increased lung adenocarcinoma incidence 2.023E-6 4.717E-5 3.217E-4 1.038E-3 4 78
23 MP:0009222 increased uterus tumor incidence 2.348E-6 5.237E-5 3.571E-4 1.205E-3 3 22
24 MP:0008716 increased lung non-small cell carcinoma incidence 2.858E-6 6.108E-5 4.165E-4 1.466E-3 4 85
25 MP:0002024 increased T cell derived lymphoma incidence 6.404E-6 1.314E-4 8.960E-4 3.285E-3 4 104
26 MP:0002947 increased hemangioma incidence 6.809E-6 1.344E-4 9.161E-4 3.493E-3 3 31
27 MP:0008942 abnormal induced cell death 9.534E-6 1.812E-4 1.235E-3 4.891E-3 5 255
28 MP:0010947 abnormal single-strand DNA break repair 1.452E-5 2.660E-4 1.814E-3 7.448E-3 2 5
29 MP:0002957 increased intestinal adenocarcinoma incidence 2.128E-5 3.764E-4 2.567E-3 1.092E-2 3 45
30 MP:0002032 increased sarcoma incidence 2.732E-5 4.672E-4 3.186E-3 1.402E-2 4 150
31 MP:0004208 increased basal cell carcinoma incidence 4.057E-5 6.713E-4 4.577E-3 2.081E-2 2 8
32 MP:0008000 increased ovary tumor incidence 4.350E-5 6.973E-4 4.755E-3 2.231E-2 3 57
33 MP:0008943 increased sensitivity to induced cell death 5.832E-5 9.066E-4 6.181E-3 2.992E-2 4 182
34 MP:0010300 increased skin tumor incidence 1.542E-4 2.326E-3 1.586E-2
7.909E-2
 3 87
35 MP:0009309 increased small intestine adenocarcinoma incidence 1.729E-4 2.534E-3 1.728E-2
8.869E-2
 2 16
36 MP:0004815 abnormal somatic hypermutation frequency 2.729E-4 3.890E-3 2.652E-2
1.400E-1
 2 20
37 MP:0008873 increased physiological sensitivity to xenobiotic 3.301E-4 4.577E-3 3.121E-2
1.693E-1
 4 285
38 MP:0008866 chromosomal instability 3.891E-4 5.253E-3 3.582E-2
1.996E-1
 3 119
39 MP:0010094 abnormal chromosome stability 4.087E-4 5.375E-3 3.665E-2
2.096E-1
 3 121
40 MP:0003324 increased liver adenoma incidence 5.017E-4 6.435E-3 4.388E-2
2.574E-1
 2 27
41 MP:0008019 increased liver tumor incidence 6.134E-4 7.675E-3
5.233E-2
3.147E-1
 3 139
42 MP:0010297 increased hepatobiliary system tumor incidence 6.529E-4 7.975E-3
5.437E-2
3.349E-1
 3 142
43 MP:0008011 intestine polyps 8.457E-4 9.860E-3
6.723E-2
4.339E-1
 2 35
44 MP:0008236 decreased susceptibility to neuronal excitotoxicity 8.457E-4 9.860E-3
6.723E-2
4.339E-1
 2 35
45 MP:0008884 abnormal enterocyte apoptosis 8.948E-4 1.020E-2
6.956E-2
4.591E-1
 2 36
46 MP:0010352 gastrointestinal tract polyps 9.971E-4 1.088E-2
7.421E-2
5.115E-1
 2 38
47 MP:0020444 abnormal intestine apoptosis 9.971E-4 1.088E-2
7.421E-2
5.115E-1
 2 38
48 MP:0010293 increased integument system tumor incidence 1.046E-3 1.100E-2
7.497E-2
5.367E-1
 3 167
49 MP:0010207 abnormal telomere morphology 1.050E-3 1.100E-2
7.497E-2
5.388E-1
 2 39
50 MP:0013829 thin splanchnic nerve 1.255E-3 1.215E-2
8.286E-2
6.440E-1
 1 1
Show 45 more annotations

6: Domain [Display Chart] 13 input genes in category / 140 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00478 ENDO3c SMART 2.610E-10 1.218E-8 6.726E-8 3.654E-8 3 3
2 IPR023170 HTH base excis C InterPro 2.610E-10 1.218E-8 6.726E-8 3.654E-8 3 3
3 1.10.1670.10 - Gene3D 2.610E-10 1.218E-8 6.726E-8 3.654E-8 3 3
4 1.10.340.30 - Gene3D 1.044E-9 2.922E-8 1.614E-7 1.461E-7 3 4
5 IPR011257 DNA glycosylase InterPro 1.044E-9 2.922E-8 1.614E-7 1.461E-7 3 4
6 PF00730 HhH-GPD Pfam 2.608E-9 5.216E-8 2.880E-7 3.651E-7 3 5
7 IPR003265 HhH-GPD domain InterPro 2.608E-9 5.216E-8 2.880E-7 3.651E-7 3 5
8 PF00633 HHH Pfam 9.120E-9 1.419E-7 7.835E-7 1.277E-6 3 7
9 IPR000445 HhH motif InterPro 9.120E-9 1.419E-7 7.835E-7 1.277E-6 3 7
10 PS00764 ENDONUCLEASE III 1 PROSITE 4.445E-7 4.148E-6 2.291E-5 6.223E-5 2 2
11 IPR004036 Endonuclease-III-like CS2 InterPro 4.445E-7 4.148E-6 2.291E-5 6.223E-5 2 2
12 PS01155 ENDONUCLEASE III 2 PROSITE 4.445E-7 4.148E-6 2.291E-5 6.223E-5 2 2
13 IPR003651 Endouclease3 FeS-loop motif InterPro 4.445E-7 4.148E-6 2.291E-5 6.223E-5 2 2
14 IPR004035 Endouclease-III FeS-bd BS InterPro 4.445E-7 4.148E-6 2.291E-5 6.223E-5 2 2
15 SM00525 FES SMART 4.445E-7 4.148E-6 2.291E-5 6.223E-5 2 2
16 IPR007695 DNA mismatch repair MutS-lik N InterPro 1.333E-6 1.098E-5 6.062E-5 1.866E-4 2 3
17 PF01624 MutS I Pfam 1.333E-6 1.098E-5 6.062E-5 1.866E-4 2 3
18 PF05188 MutS II Pfam 2.665E-6 1.942E-5 1.073E-4 3.731E-4 2 4
19 IPR007860 DNA mmatch repair MutS con dom InterPro 2.665E-6 1.942E-5 1.073E-4 3.731E-4 2 4
20 PF00488 MutS V Pfam 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
21 SM00533 MUTSd SMART 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
22 IPR013507 DNA mismatch repair C InterPro 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
23 IPR002099 DNA mismatch repair fam InterPro 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
24 IPR007696 DNA mismatch repair MutS core InterPro 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
25 PS00486 DNA MISMATCH REPAIR 2 PROSITE 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
26 IPR000432 DNA mismatch repair MutS C InterPro 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
27 PF05192 MutS III Pfam 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
28 PF01119 DNA mis repair Pfam 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
29 SM00534 MUTSac SMART 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
30 PS00058 DNA MISMATCH REPAIR 1 PROSITE 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
31 IPR007861 DNA mismatch repair MutS clamp InterPro 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
32 PF05190 MutS IV Pfam 4.439E-6 1.942E-5 1.073E-4 6.215E-4 2 5
33 IPR014762 DNA mismatch repair CS InterPro 6.657E-6 2.824E-5 1.560E-4 9.319E-4 2 6
34 SM00387 HATPase c SMART 6.758E-5 2.783E-4 1.537E-3 9.461E-3 2 18
35 PF02518 HATPase c Pfam 7.550E-5 3.020E-4 1.668E-3 1.057E-2 2 19
36 IPR003594 HATPase C InterPro 1.019E-4 3.962E-4 2.188E-3 1.426E-2 2 22
37 IPR014721 Ribosomal S5 D2-typ fold subgr InterPro 1.115E-4 4.220E-4 2.330E-3 1.561E-2 2 23
38 IPR020568 Ribosomal S5 D2-typ fold InterPro 2.611E-4 9.618E-4 5.312E-3 3.655E-2 2 35
39 IPR029119 MutY C InterPro 6.939E-4 1.542E-3 8.515E-3
9.714E-2
 1 1
40 PF14815 NUDIX 4 Pfam 6.939E-4 1.542E-3 8.515E-3
9.714E-2
 1 1
41 PF01035 DNA binding 1 Pfam 6.939E-4 1.542E-3 8.515E-3
9.714E-2
 1 1
42 PF02870 Methyltransf 1N Pfam 6.939E-4 1.542E-3 8.515E-3
9.714E-2
 1 1
43 PF09292 Neil1-DNA bind Pfam 6.939E-4 1.542E-3 8.515E-3
9.714E-2
 1 1
44 IPR001497 MethylDNA cys MeTrfase AS InterPro 6.939E-4 1.542E-3 8.515E-3
9.714E-2
 1 1
45 SM00898 Fapy DNA glyco SMART 6.939E-4 1.542E-3 8.515E-3
9.714E-2
 1 1
46 IPR023426 Flap endonuc InterPro 6.939E-4 1.542E-3 8.515E-3
9.714E-2
 1 1
47 IPR030841 NTH1 InterPro 6.939E-4 1.542E-3 8.515E-3
9.714E-2
 1 1
48 PF16413 Mlh1 C Pfam 6.939E-4 1.542E-3 8.515E-3
9.714E-2
 1 1
49 IPR006551 Polynucleotide phosphatase InterPro 6.939E-4 1.542E-3 8.515E-3
9.714E-2
 1 1
50 PF08645 PNK3P Pfam 6.939E-4 1.542E-3 8.515E-3
9.714E-2
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 13 input genes in category / 68 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270350 DNA Repair BioSystems: REACTOME 1.611E-21 1.096E-19 5.264E-19 1.096E-19 13 319
2 1270359 Resolution of Abasic Sites (AP sites) BioSystems: REACTOME 3.443E-18 7.803E-17 3.749E-16 2.341E-16 8 37
3 1270351 Base Excision Repair BioSystems: REACTOME 3.443E-18 7.803E-17 3.749E-16 2.341E-16 8 37
4 83043 Base excision repair BioSystems: KEGG 7.895E-16 1.342E-14 6.448E-14 5.369E-14 7 33
5 PW:0000668 altered mismatch repair pathway Pathway Ontology 3.571E-12 4.856E-11 2.333E-10 2.428E-10 4 5
6 1270363 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway BioSystems: REACTOME 2.497E-11 2.830E-10 1.359E-9 1.698E-9 4 7
7 1270360 Displacement of DNA glycosylase by APEX1 BioSystems: REACTOME 8.978E-11 8.721E-10 4.190E-9 6.105E-9 4 9
8 1270352 Base-Excision Repair, AP Site Formation BioSystems: REACTOME 1.495E-10 1.271E-9 6.106E-9 1.017E-8 4 10
9 1270412 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) BioSystems: REACTOME 9.692E-10 7.323E-9 3.518E-8 6.591E-8 4 15
10 1270411 Mismatch Repair BioSystems: REACTOME 1.292E-9 8.782E-9 4.219E-8 8.782E-8 4 16
11 PW:0000612 colorectal cancer Pathway Ontology 2.169E-9 1.341E-8 6.441E-8 1.475E-7 4 18
12 83045 Mismatch repair BioSystems: KEGG 6.258E-9 3.546E-8 1.704E-7 4.256E-7 4 23
13 PW:0000662 mismatch repair pathway Pathway Ontology 1.055E-8 5.517E-8 2.651E-7 7.172E-7 4 26
14 1270365 POLB-Dependent Long Patch Base Excision Repair BioSystems: REACTOME 3.106E-8 1.508E-7 7.246E-7 2.112E-6 3 7
15 1270357 Recognition and association of DNA glycosylase with site containing an affected pyrimidine BioSystems: REACTOME 4.966E-8 1.986E-7 9.542E-7 3.377E-6 3 8
16 1270358 Cleavage of the damaged pyrimidine BioSystems: REACTOME 4.966E-8 1.986E-7 9.542E-7 3.377E-6 3 8
17 1270356 Depyrimidination BioSystems: REACTOME 4.966E-8 1.986E-7 9.542E-7 3.377E-6 3 8
18 1270413 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) BioSystems: REACTOME 4.018E-7 1.518E-6 7.292E-6 2.732E-5 3 15
19 1270362 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway BioSystems: REACTOME 1.007E-6 3.602E-6 1.731E-5 6.844E-5 2 2
20 1270366 PCNA-Dependent Long Patch Base Excision Repair BioSystems: REACTOME 1.170E-6 3.979E-6 1.911E-5 7.957E-5 3 21
21 1270364 Resolution of AP sites via the multiple-nucleotide patch replacement pathway BioSystems: REACTOME 1.778E-6 5.756E-6 2.765E-5 1.209E-4 3 24
22 1270355 Cleavage of the damaged purine BioSystems: REACTOME 3.018E-6 8.550E-6 4.108E-5 2.052E-4 2 3
23 1270354 Recognition and association of DNA glycosylase with site containing an affected purine BioSystems: REACTOME 3.018E-6 8.550E-6 4.108E-5 2.052E-4 2 3
24 1270353 Depurination BioSystems: REACTOME 3.018E-6 8.550E-6 4.108E-5 2.052E-4 2 3
25 1270361 Resolution of AP sites via the single-nucleotide replacement pathway BioSystems: REACTOME 6.032E-6 1.641E-5 7.882E-5 4.102E-4 2 4
26 83106 Colorectal cancer BioSystems: KEGG 2.941E-5 7.691E-5 3.695E-4 2.000E-3 3 60
27 1383075 TP53 Regulates Transcription of DNA Repair Genes BioSystems: REACTOME 5.088E-5 1.282E-4 6.156E-4 3.460E-3 3 72
28 1404797 Platinum drug resistance BioSystems: KEGG 5.303E-5 1.288E-4 6.187E-4 3.606E-3 3 73
29 137939 Direct p53 effectors BioSystems: Pathway Interaction Database 3.083E-4 7.228E-4 3.473E-3 2.096E-2 3 132
30 1270376 MGMT-mediated DNA damage reversal BioSystems: REACTOME 1.044E-3 2.367E-3 1.137E-2
7.100E-2
 1 1
31 377262 Fanconi anemia pathway BioSystems: KEGG 1.449E-3 3.178E-3 1.527E-2
9.851E-2
 2 55
32 PW:0000129 base excision repair Pathway Ontology 4.171E-3 8.863E-3 4.258E-2
2.836E-1
 1 4
33 1269654 Transcriptional Regulation by TP53 BioSystems: REACTOME 6.146E-3 1.266E-2
6.084E-2
4.179E-1
 3 374
34 83105 Pathways in cancer BioSystems: KEGG 7.151E-3 1.430E-2
6.871E-2
4.863E-1
 3 395
35 1270375 DNA Damage Reversal BioSystems: REACTOME 8.325E-3 1.617E-2
7.770E-2
5.661E-1
 1 8
36 1269863 Removal of the Flap Intermediate from the C-strand BioSystems: REACTOME 1.040E-2 1.964E-2
9.434E-2
7.070E-1
 1 10
37 1269862 Processive synthesis on the C-strand of the telomere BioSystems: REACTOME 1.143E-2 1.993E-2
9.575E-2
7.773E-1
 1 11
38 M3075 Granzyme A mediated Apoptosis Pathway MSigDB C2 BIOCARTA (v6.0) 1.143E-2 1.993E-2
9.575E-2
7.773E-1
 1 11
39 1309109 HDR through MMEJ (alt-NHEJ) BioSystems: REACTOME 1.143E-2 1.993E-2
9.575E-2
7.773E-1
 1 11
40 83047 Non-homologous end-joining BioSystems: KEGG 1.350E-2 2.294E-2
1.102E-1
9.177E-1
 1 13
41 1269059 Early Phase of HIV Life Cycle BioSystems: REACTOME 1.453E-2 2.352E-2
1.130E-1
9.878E-1
 1 14
42 1269790 Removal of the Flap Intermediate BioSystems: REACTOME 1.453E-2 2.352E-2
1.130E-1
9.878E-1
 1 14
43 1269789 Processive synthesis on the lagging strand BioSystems: REACTOME 1.556E-2 2.460E-2
1.182E-1
1.000E0
 1 15
44 1269788 Lagging Strand Synthesis BioSystems: REACTOME 2.069E-2 3.198E-2
1.536E-1
1.000E0
 1 20
45 1269859 Telomere C-strand (Lagging Strand) Synthesis BioSystems: REACTOME 2.478E-2 3.745E-2
1.799E-1
1.000E0
 1 24
46 1269857 Extension of Telomeres BioSystems: REACTOME 3.191E-2 4.716E-2
2.266E-1
1.000E0
 1 31
47 1269784 DNA strand elongation BioSystems: REACTOME 3.292E-2 4.763E-2
2.288E-1
1.000E0
 1 32
48 137956 HIF-2-alpha transcription factor network BioSystems: Pathway Interaction Database 3.494E-2 4.950E-2
2.378E-1
1.000E0
 1 34
Show 43 more annotations

8: Pubmed [Display Chart] 13 input genes in category / 4346 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20496165 Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Pubmed 4.555E-26 1.980E-22 1.773E-21 1.980E-22 10 68
2 17417778 Genetic investigation of DNA-repair pathway genes PMS2, MLH1, MSH2, MSH6, MUTYH, OGG1 and MTH1 in sporadic colon cancer. Pubmed 2.787E-21 6.056E-18 5.423E-17 1.211E-17 6 7
3 19536092 Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. Pubmed 1.389E-20 2.012E-17 1.802E-16 6.036E-17 8 55
4 20226869 Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. Pubmed 3.500E-20 3.803E-17 3.405E-16 1.521E-16 7 25
5 20574454 Polymorphisms in the base excision repair pathway and graft-versus-host disease. Pubmed 6.464E-20 5.619E-17 5.031E-16 2.809E-16 7 27
6 20522537 Variation within DNA repair pathway genes and risk of multiple sclerosis. Pubmed 1.530E-19 1.108E-16 9.924E-16 6.650E-16 8 73
7 19237606 Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Pubmed 4.956E-19 3.077E-16 2.755E-15 2.154E-15 8 84
8 21425258 Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas. Pubmed 1.901E-18 1.033E-15 9.247E-15 8.261E-15 5 5
9 18091433 Heterogeneous molecular mechanisms underlie attenuated familial adenomatous polyposis. Pubmed 3.990E-17 1.927E-14 1.725E-13 1.734E-13 5 7
10 20150366 DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Pubmed 7.031E-17 3.056E-14 2.736E-13 3.056E-13 6 25
11 19692168 Genetic susceptibility to distinct bladder cancer subphenotypes. Pubmed 1.550E-15 6.125E-13 5.484E-12 6.737E-12 9 422
12 16609022 Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer. Pubmed 5.698E-15 9.474E-13 8.483E-12 2.477E-11 5 15
13 18841495 High risk of endometrial cancer in colorectal cancer kindred is pathognomonic for MMR-mutation carriers. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
14 19707776 Colorectal cancer in Iran: immunohistochemical profiles of four mismatch repair proteins. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
15 23434150 Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers? Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
16 26544533 Constitutional Mismatch Repair Deficiency in Israel: High Proportion of Founder Mutations in MMR Genes and Consanguinity. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
17 16740762 Germ line mutations of mismatch repair genes in hereditary nonpolyposis colorectal cancer patients with small bowel cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative Study. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
18 25083964 Immunohistochemical survey of mismatch repair protein expression in uterine sarcomas and carcinosarcomas. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
19 24444820 Mismatch repair protein expression in 1049 endometrial carcinomas, associations with body mass index, and other clinicopathologic variables. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
20 24989436 A review of mismatch repair gene transcripts: issues for interpretation of mRNA splicing assays. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
21 19898223 Endometrial carcinomas in women aged 40 years and younger: tumors associated with loss of DNA mismatch repair proteins comprise a distinct clinicopathologic subset. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
22 26224637 Evidence that the DNA mismatch repair system removes 1-nucleotide Okazaki fragment flaps. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
23 16403449 Analysis of the human MutLalpha.MutSalpha complex. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
24 21559014 Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
25 21911971 Mismatch repair genes expression defects & association with clinicopathological characteristics in colorectal carcinoma. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
26 26097592 Relationship between MLH-1, MSH-2, PMS-2,MSH-6 expression and clinicopathological features in colorectal cancer. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
27 17493242 DNA mismatch repair protein expression and microsatellite instability in primary mucosal melanomas of the head and neck. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
28 24323032 Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 years optimizes triage for population-level germline mismatch repair gene mutation testing. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
29 19132747 PMS2 involvement in patients suspected of Lynch syndrome. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
30 27601186 Mismatch repair gene mutation spectrum in the Swedish Lynch syndrome population. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
31 17653898 Nine novel pathogenic germline mutations in MLH1, MSH2, MSH6 and PMS2 in families with Lynch syndrome. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
32 19244167 Prediction of Lynch syndrome in consecutive patients with colorectal cancer. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
33 16885385 Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
34 24995467 Expression of DNA mismatch repair proteins MLH1, MSH2, and MSH6 in recurrent glioblastoma. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
35 24643686 Immunohistochemical expression pattern of MMR protein can specifically identify patients with colorectal cancer microsatellite instability. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
36 16116158 Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
37 19526325 Screening for germline mutations of MLH1, MSH2, MSH6 and PMS2 genes in Slovenian colorectal cancer patients: implications for a population specific detection strategy of Lynch syndrome. Pubmed 8.066E-15 9.474E-13 8.483E-12 3.505E-11 4 4
38 18270339 Comprehensive analysis of DNA repair gene variants and risk of meningioma. Pubmed 1.434E-14 1.639E-12 1.468E-11 6.230E-11 6 57
39 19997493 Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice. Pubmed 4.032E-14 4.075E-12 3.649E-11 1.752E-10 4 5
40 12799449 N-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalpha. Pubmed 4.032E-14 4.075E-12 3.649E-11 1.752E-10 4 5
41 16728433 Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6. Pubmed 4.032E-14 4.075E-12 3.649E-11 1.752E-10 4 5
42 10748159 Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA. Pubmed 4.032E-14 4.075E-12 3.649E-11 1.752E-10 4 5
43 17312306 Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics. Pubmed 4.032E-14 4.075E-12 3.649E-11 1.752E-10 4 5
44 20453000 A Large-scale genetic association study of esophageal adenocarcinoma risk. Pubmed 5.810E-14 5.739E-12 5.139E-11 2.525E-10 8 351
45 19625176 PTEN identified as important risk factor of chronic obstructive pulmonary disease. Pubmed 1.010E-13 9.754E-12 8.734E-11 4.389E-10 8 376
46 18676680 Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. Pubmed 1.123E-13 1.031E-11 9.229E-11 4.880E-10 8 381
47 19170196 Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. Pubmed 1.171E-13 1.031E-11 9.229E-11 5.090E-10 8 383
48 15260972 AP endonuclease-independent DNA base excision repair in human cells. Pubmed 1.209E-13 1.031E-11 9.229E-11 5.256E-10 4 6
49 12200441 A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. Pubmed 1.209E-13 1.031E-11 9.229E-11 5.256E-10 4 6
50 11223406 DNA mismatch repair and cancer. Pubmed 1.209E-13 1.031E-11 9.229E-11 5.256E-10 4 6
Show 45 more annotations

9: Interaction [Display Chart] 13 input genes in category / 576 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PCNA PCNA interactions 1.236E-13 7.121E-11 4.938E-10 7.121E-11 9 320
2 int:MSH2 MSH2 interactions 4.695E-12 1.352E-9 9.376E-9 2.704E-9 7 151
3 int:MSH6 MSH6 interactions 6.251E-11 1.200E-8 8.323E-8 3.601E-8 6 105
4 int:MUTYH MUTYH interactions 1.742E-10 2.509E-8 1.740E-7 1.004E-7 4 14
5 int:RAD1 RAD1 interactions 1.269E-9 1.434E-7 9.945E-7 7.310E-7 4 22
6 int:XRCC1 XRCC1 interactions 1.494E-9 1.434E-7 9.945E-7 8.605E-7 5 75
7 int:RAD9A RAD9A interactions 1.139E-8 9.371E-7 6.498E-6 6.560E-6 4 37
8 int:MSH3 MSH3 interactions 1.574E-8 1.133E-6 7.858E-6 9.066E-6 4 40
9 int:POLB POLB interactions 1.926E-8 1.233E-6 8.548E-6 1.110E-5 4 42
10 int:PMS2 PMS2 interactions 5.017E-8 2.890E-6 2.004E-5 2.890E-5 4 53
11 int:FEN1 FEN1 interactions 2.547E-7 1.334E-5 9.248E-5 1.467E-4 4 79
12 int:TFCP2L1 TFCP2L1 interactions 5.138E-7 2.466E-5 1.710E-4 2.959E-4 4 94
13 int:APEX1 APEX1 interactions 7.715E-7 3.419E-5 2.370E-4 4.444E-4 4 104
14 int:PRKDC PRKDC interactions 1.386E-6 5.701E-5 3.953E-4 7.981E-4 5 293
15 int:EXO1 EXO1 interactions 1.516E-6 5.820E-5 4.036E-4 8.730E-4 3 32
16 int:MCM9 MCM9 interactions 1.997E-6 7.191E-5 4.986E-4 1.151E-3 3 35
17 int:MRE11 MRE11 interactions 2.325E-6 7.762E-5 5.382E-4 1.339E-3 4 137
18 int:BLM BLM interactions 2.535E-6 7.762E-5 5.382E-4 1.460E-3 4 140
19 int:XRCC6 XRCC6 interactions 2.560E-6 7.762E-5 5.382E-4 1.475E-3 5 332
20 int:MLH1 MLH1 interactions 3.610E-6 1.030E-4 7.139E-4 2.079E-3 4 153
21 int:BRIP1 BRIP1 interactions 3.753E-6 1.030E-4 7.139E-4 2.162E-3 3 43
22 int:SMC1A SMC1A interactions 4.420E-6 1.157E-4 8.025E-4 2.546E-3 4 161
23 int:SUPT16H SUPT16H interactions 5.234E-6 1.311E-4 9.089E-4 3.015E-3 4 168
24 int:PARP2 PARP2 interactions 8.847E-6 2.123E-4 1.472E-3 5.096E-3 3 57
25 int:ATM ATM interactions 9.832E-6 2.226E-4 1.544E-3 5.663E-3 4 197
26 int:NEIL1 NEIL1 interactions 1.043E-5 2.226E-4 1.544E-3 6.009E-3 2 7
27 int:MMS19 MMS19 interactions 1.044E-5 2.226E-4 1.544E-3 6.011E-3 4 200
28 int:PMS1 PMS1 interactions 1.256E-5 2.584E-4 1.792E-3 7.234E-3 3 64
29 int:DTL DTL interactions 1.378E-5 2.738E-4 1.898E-3 7.939E-3 3 66
30 int:RPA1 RPA1 interactions 1.825E-5 3.470E-4 2.406E-3 1.051E-2 5 497
31 int:LIG3 LIG3 interactions 1.868E-5 3.470E-4 2.406E-3 1.076E-2 3 73
32 int:PSD3 PSD3 interactions 2.233E-5 4.019E-4 2.787E-3 1.286E-2 2 10
33 int:RFC1 RFC1 interactions 2.848E-5 4.825E-4 3.346E-3 1.640E-2 3 84
34 int:HUS1 HUS1 interactions 2.848E-5 4.825E-4 3.346E-3 1.640E-2 3 84
35 int:XRCC5 XRCC5 interactions 3.806E-5 6.184E-4 4.288E-3 2.192E-2 4 278
36 int:GZMK GZMK interactions 3.865E-5 6.184E-4 4.288E-3 2.226E-2 2 13
37 int:NBN NBN interactions 4.519E-5 7.035E-4 4.878E-3 2.603E-2 3 98
38 int:RPA4 RPA4 interactions 5.199E-5 7.880E-4 5.464E-3 2.995E-2 2 15
39 int:RAD50 RAD50 interactions 8.897E-5 1.314E-3 9.112E-3
5.125E-2
 3 123
40 int:SSRP1 SSRP1 interactions 1.540E-4 2.218E-3 1.538E-2
8.870E-2
 3 148
41 int:RPA3 RPA3 interactions 1.685E-4 2.368E-3 1.642E-2
9.707E-2
 4 408
42 int:MCM3 MCM3 interactions 1.799E-4 2.467E-3 1.711E-2
1.036E-1
 3 156
43 int:MCM8 MCM8 interactions 2.439E-4 3.267E-3 2.265E-2
1.405E-1
 2 32
44 int:CLSPN CLSPN interactions 2.595E-4 3.397E-3 2.355E-2
1.495E-1
 2 33
45 int:RPA2 RPA2 interactions 2.899E-4 3.710E-3 2.573E-2
1.670E-1
 4 470
46 int:RECQL RECQL interactions 3.633E-4 4.549E-3 3.154E-2
2.092E-1
 2 39
47 int:TPP2 TPP2 interactions 4.017E-4 4.922E-3 3.413E-2
2.314E-1
 2 41
48 int:POLK POLK interactions 4.841E-4 5.809E-3 4.028E-2
2.789E-1
 2 45
49 int:SLX4 SLX4 interactions 5.059E-4 5.947E-3 4.124E-2
2.914E-1
 2 46
50 int:FAN1 FAN1 interactions 5.282E-4 6.085E-3 4.219E-2
3.042E-1
 2 47
Show 45 more annotations

10: Cytoband [Display Chart] 13 input genes in category / 13 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3p26.2 3p26.2 1.499E-3 1.362E-2 4.332E-2 1.949E-2 1 4
2 7p22.2 7p22.2 3.745E-3 1.362E-2 4.332E-2 4.868E-2 1 10
3 2p16 2p16 4.492E-3 1.362E-2 4.332E-2
5.840E-2
 1 12
4 19q13.3-q13.4 19q13.3-q13.4 4.866E-3 1.362E-2 4.332E-2
6.325E-2
 1 13
5 8p11.2 8p11.2 5.239E-3 1.362E-2 4.332E-2
6.811E-2
 1 14
6 11q12 11q12 7.849E-3 1.596E-2
5.075E-2
1.020E-1
 1 21
7 10q26 10q26 8.594E-3 1.596E-2
5.075E-2
1.117E-1
 1 23
8 15q24.2 15q24.2 1.231E-2 2.000E-2
6.361E-2
1.600E-1
 1 33
9 1p34.1 1p34.1 2.117E-2 2.849E-2
9.062E-2
2.752E-1
 1 57
10 3p21.3 3p21.3 2.228E-2 2.849E-2
9.062E-2
2.896E-1
 1 60
11 2p21 2p21 2.411E-2 2.849E-2
9.062E-2
3.134E-1
 1 65
Show 6 more annotations

11: Transcription Factor Binding Site [Display Chart] 10 input genes in category / 63 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 10 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1024 DNA glycosylases genenames.org 1.516E-11 9.093E-11 2.228E-10 9.093E-11 4 11
2 1027 MutL homologs genenames.org 1.630E-6 4.891E-6 1.198E-5 9.783E-6 2 4
3 1026 MutS homologs genenames.org 2.717E-6 5.433E-6 1.331E-5 1.630E-5 2 5
4 1045 HAD Asp-based non-protein phosphatases genenames.org 6.031E-3 9.047E-3 2.216E-2 3.619E-2 1 11
5 1147 PHD finger proteins|Lysine methyltransferases|PWWP domain containing genenames.org 1.203E-2 1.257E-2 3.080E-2
7.218E-2
 1 22
6 535 DNA polymerases genenames.org 1.257E-2 1.257E-2 3.080E-2
7.544E-2
 1 23
Show 1 more annotation

13: Coexpression [Display Chart] 13 input genes in category / 1354 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.575E-27 8.903E-24 6.934E-23 8.903E-24 13 230
2 M9575 DNA repair genes whose promoters contain putative ZNF143 [GeneID=7702] binding sites. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.201E-18 8.131E-16 6.333E-15 1.626E-15 8 58
3 M123 Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells, embryonical carcinomas and induced pluripotent cells). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.045E-9 3.180E-6 2.477E-5 9.539E-6 6 299
4 20460173-ImmPortCentrocytevsMemory Human Immune Kong10 79genes Immune Kong10 genes ImmPort CentrocytevsMemory GeneSigDB 3.979E-8 1.347E-5 1.049E-4 5.387E-5 4 65
5 M3337 Genes up-regulated in comparison of polysome bound (translated) mRNA before and 4 h after LPS (TLR4 agonist) stimulation. MSigDB C7: Immunologic Signatures (v6.0) 5.447E-8 1.475E-5 1.149E-4 7.375E-5 5 199
6 20460173-ImmPortCentrocytevsNaive Human Immune Kong10 109genes ImmPort CentrocytevsNaive GeneSigDB 9.729E-8 2.196E-5 1.710E-4 1.317E-4 4 81
7 M9150 Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.036E-7 1.168E-4 9.093E-4 8.173E-4 5 323
8 M9372 Genes involved in DNA replication, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.041E-6 1.637E-4 1.275E-3 1.409E-3 4 146
9 14993899-TableS1 Human Futreal04 427genes ConsensusCancerGenes GeneSigDB 1.088E-6 1.637E-4 1.275E-3 1.473E-3 5 364
10 16886892-Table2 Human Breast Chalabi06 57genes GeneSigDB 2.074E-6 2.809E-4 2.187E-3 2.809E-3 3 46
11 16397240-Table1e Human Colon Grade06 58genes GeneSigDB 2.362E-6 2.907E-4 2.264E-3 3.198E-3 3 48
12 M4493 Genes whose promoters were bound by E2F1 and E2F4 [GeneID=1869;1874] in the primary fibroblasts WI-38, by ChIP on chip assay. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.894E-6 5.097E-4 3.970E-3 6.626E-3 3 61
13 M2431 DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.894E-6 5.097E-4 3.970E-3 6.626E-3 3 61
14 16790086-tableW1 Rat Liver Perez-Carreon06 290genes GeneSigDB 6.232E-6 6.027E-4 4.694E-3 8.438E-3 4 229
15 M15356 Genes constituting the LIT-Int network of proteins interacting with breast cancer reference proteins BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200]; the interactions were manually curated from the literature. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.237E-5 2.019E-3 1.573E-2 3.029E-2 3 101
16 M2879 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.018E-5 2.554E-3 1.989E-2 4.087E-2 4 342
17 12935928-Table2 Human Liver Nagata03 17genes GeneSigDB 3.482E-5 2.773E-3 2.160E-2 4.714E-2 2 16
18 M1871 Set 'ES exp1': genes overexpressed in human embryonic stem cells according to 5 or more out of 20 profiling studies. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.507E-5 3.237E-3 2.521E-2
6.103E-2
 4 379
19 M13537 Genes up-regulated in MEWO cells (melanoma) after 48h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.542E-5 3.237E-3 2.521E-2
6.150E-2
 3 128
20 21205295-TableS5 Mouse Viral Buonomo11 202genes GeneSigDB 5.207E-5 3.525E-3 2.745E-2
7.050E-2
 3 134
21 M9516 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.910E-5 4.455E-3 3.470E-2
9.356E-2
 4 423
22 15988031-TableS5 Human StemCell Li05 279genes GeneSigDB 8.986E-5 5.470E-3 4.260E-2
1.217E-1
 3 161
23 M13108 Genes down-regulated in Wilm's tumor samples compared to fetal kidney. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.321E-5 5.470E-3 4.260E-2
1.262E-1
 3 163
24 M6853 Genes up-regulated in spleens: LPS versus monophosphoryl lipid A. MSigDB C7: Immunologic Signatures (v6.0) 1.002E-4 5.470E-3 4.260E-2
1.356E-1
 3 167
25 M1233 Genes showing frequent DNA methylation and which are silenced in adult cancers but remain unmethylated in embryonic carcinoma and embryonic stem (ES) cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.015E-4 5.470E-3 4.260E-2
1.374E-1
 2 27
26 M6909 Genes up-regulated in macrophages with IL10 [GeneID=3586] knockout treated by LPS and IL10 [GeneID=3586]: 10 min versus 30 min. MSigDB C7: Immunologic Signatures (v6.0) 1.056E-4 5.470E-3 4.260E-2
1.430E-1
 3 170
27 M12717 Genes un-methylated aberrantly in HCT116 and Colo320 (colon cancer) cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.093E-4 5.470E-3 4.260E-2
1.479E-1
 2 28
28 M2639 Genes up-regulated in granule cell neuron precursors (GCNPs) after stimulation with Shh for 3h. MSigDB C6: Oncogenic Signatures (v6.0) 1.131E-4 5.470E-3 4.260E-2
1.532E-1
 3 174
29 M1452 Genes down-regulated in RAW 264.7 cells (macrophage) 3 hr after stimulation with bacterial lipopolysaccharide (LPS). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.432E-4 6.264E-3 4.879E-2
1.939E-1
 2 32
30 M6438 Genes down-regulated in hepatocellular carcinoma (HCC) cell lines resistant to IFNA2 [GeneID=3440]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.618E-4 6.264E-3 4.879E-2
2.191E-1
 2 34
31 M9916 Genes down-regulated in B lymphocytes: untreated versus anti-IgM for 3h. MSigDB C7: Immunologic Signatures (v6.0) 1.657E-4 6.264E-3 4.879E-2
2.244E-1
 3 198
32 M5514 Genes down-regulated in comparison of macrophages versus Th2 cells. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 6.264E-3 4.879E-2
2.311E-1
 3 200
33 M5246 Genes down-regulated in comparison of macrophages exposed to L. major versus macrophages exposed to T. gondii. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 6.264E-3 4.879E-2
2.311E-1
 3 200
34 M7147 Genes up-regulated in CD8A- [GeneID=925] splenic dendritic cells: wildtype versus IFNAR1 [GeneID=3454] knockout mice. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 6.264E-3 4.879E-2
2.311E-1
 3 200
35 M5925 Genes encoding cell cycle related targets of E2F transcription factors. MSigDB H: Hallmark Gene Sets (v6.0) 1.707E-4 6.264E-3 4.879E-2
2.311E-1
 3 200
36 M9850 Genes up-regulated in CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4intermediate versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 6.264E-3 4.879E-2
2.311E-1
 3 200
37 18992152-table4 Human Lung Rohrbeck08 42genes SCLC GeneSigDB 1.716E-4 6.264E-3 4.879E-2
2.323E-1
 2 35
38 M19511 Genes up-regulated in fibroblasts with defective XPC [GeneID=7508] in response to cisplatin [PubChem=2767]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.758E-4 6.264E-3 4.879E-2
2.380E-1
 3 202
39 16574953-Table1 Human Leukemia Rudd06 49genes GeneSigDB 1.919E-4 6.664E-3
5.190E-2
2.599E-1
 2 37
40 M1819 Meitic and DNA repair genes important for female fertility, based on mouse models with female fertility defects. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.134E-4 7.225E-3
5.627E-2
2.890E-1
 2 39
41 M1681 Cluster 4: genes maximally expressed at 16 h time point during differentiation of 3T3-L1 fibroblasts into adipocytes in response to adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.246E-4 7.417E-3
5.777E-2
3.041E-1
 2 40
42 15817677-TableS2c Human Leukemia Falt05 50genes UpRegulatedVH3a GeneSigDB 2.360E-4 7.609E-3
5.926E-2
3.196E-1
 2 41
43 M1476 B lymphocyte early differentiation genes (EDG): top genes down-regulated in tonsil B lymphocytes (TBC) compared to the tonsil plasma cells (TPC). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.478E-4 7.801E-3
6.076E-2
3.355E-1
 2 42
44 M27 Set 'Myc targets1': targets of c-Myc [GeneID=4609] identified by ChIP on chip in cultured cell lines, focusing on E-box-containing genes; high affinity bound subset MSigDB C2: CGP Curated Gene Sets (v6.0) 2.576E-4 7.928E-3
6.174E-2
3.488E-1
 3 230
45 16081686-SuppTable1 Human Lymphoma Tome05 151genes GeneSigDB 2.846E-4 8.377E-3
6.525E-2
3.854E-1
 2 45
46 M2536 Proteins interacting with AIRE [GeneID=326], based on massspectroscopy analysis of co-immunoprecipitates in 293T cells (embryonic kidney). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.846E-4 8.377E-3
6.525E-2
3.854E-1
 2 45
47 19377508-SuppTable3 Human Lymphoma Chin09 65genes GeneSigDB 3.106E-4 8.792E-3
6.847E-2
4.205E-1
 2 47
48 17145885-SuppTable2 Human Lung Kobayashi06 320genes GeneSigDB 3.176E-4 8.792E-3
6.847E-2
4.300E-1
 3 247
49 15709204-Table1 Human Liver Wong05 55genes GeneSigDB 3.240E-4 8.792E-3
6.847E-2
4.387E-1
 2 48
50 M16010 Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.329E-4 8.792E-3
6.847E-2
4.508E-1
 3 251
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 13 input genes in category / 501 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Sample Type by Project: Shred 1/TCGA-Bladder/Urothelial Carcinoma/Papillary Muscle Invasive Urothelial Carcinoma/2/4 Sample Type by Project: Shred 1/TCGA-Bladder/Urothelial Carcinoma/Papillary Muscle Invasive Urothelial Carcinoma/2/4 TCGA-Bladder 1.635E-4 4.429E-2
3.009E-1
8.191E-2
 3 186
2 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/Slamf1-positive multipotent progenitor cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/Slamf1-positive multipotent progenitor cell Tabula Muris Consortium 1.768E-4 4.429E-2
3.009E-1
8.858E-2
 3 191

15: Computational [Display Chart] 10 input genes in category / 100 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M10242 GNF2 MSH2 Neighborhood of MSH2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.006E-8 1.006E-6 5.217E-6 1.006E-6 4 28
2 M5444 GNF2 RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.359E-7 8.593E-6 4.457E-5 2.359E-5 4 60
3 M15029 MODULE 360 Genes in the cancer module 360. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.578E-7 8.593E-6 4.457E-5 2.578E-5 3 14
4 M16421 GNF2 MSH6 Neighborhood of MSH6 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.155E-6 7.888E-5 4.092E-4 3.155E-4 3 31
5 M18640 GNF2 MLH1 Neighborhood of MLH1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.012E-6 1.602E-4 8.312E-4 8.012E-4 3 42
6 M4550 MODULE 252 TFs and nuclear. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.692E-5 8.965E-4 4.651E-3 5.692E-3 4 237
7 M14632 MORF PCNA Neighborhood of PCNA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.276E-5 8.965E-4 4.651E-3 6.276E-3 3 83
8 M17658 MODULE 198 Genes in the cancer module 198. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.481E-4 1.851E-3 9.601E-3 1.481E-2 4 303
9 M9465 MODULE 372 Genes in the cancer module 372. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.437E-4 2.708E-3 1.405E-2 2.437E-2 2 24
10 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.028E-4 4.028E-3 2.090E-2 4.028E-2 4 393
11 M956 MODULE 8 Genes in the cancer module 8. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.238E-4 4.762E-3 2.470E-2
5.238E-2
 4 421
12 M7614 MODULE 126 Lymphoma and immune response expression clusters. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.511E-4 5.234E-3 2.715E-2
6.511E-2
 3 183
13 M15619 MODULE 18 Genes in the cancer module 18. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.804E-4 5.234E-3 2.715E-2
6.804E-2
 4 451
14 M5464 MODULE 403 DNA damage response. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.034E-4 6.453E-3 3.347E-2
9.034E-2
 2 46
15 M14325 GNF2 FEN1 Neighborhood of FEN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.337E-3 8.913E-3 4.624E-2
1.337E-1
 2 56
16 M11522 GNF2 MCM5 Neighborhood of MCM5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.585E-3 9.092E-3 4.716E-2
1.585E-1
 2 61
17 M17234 MORF MSH2 Neighborhood of MSH2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.585E-3 9.092E-3 4.716E-2
1.585E-1
 2 61
18 M1046 MORF SMC1L1 Neighborhood of SMC1L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.636E-3 9.092E-3 4.716E-2
1.636E-1
 2 62
19 M17279 GNF2 PCNA Neighborhood of PCNA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.965E-3 1.034E-2
5.365E-2
1.965E-1
 2 68
20 M6530 MORF UNG Neighborhood of UNG MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.448E-3 1.224E-2
6.350E-2
2.448E-1
 2 76
21 M12856 GNF2 SMC4L1 Neighborhood of SMC4L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.982E-3 1.420E-2
7.364E-2
2.982E-1
 2 84
22 M16712 MODULE 204 Genes in the cancer module 204. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.123E-3 1.420E-2
7.364E-2
3.123E-1
 2 86
23 M11786 GNF2 RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.267E-3 1.421E-2
7.369E-2
3.267E-1
 2 88
24 M1104 MORF RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.364E-3 1.818E-2
9.432E-2
4.364E-1
 2 102
25 M4409 MODULE 17 Genes in the cancer module 17. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.803E-3 1.921E-2
9.967E-2
4.803E-1
 3 367
26 M8921 MODULE 53 Cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.331E-3 2.435E-2
1.263E-1
6.331E-1
 3 405
27 M10190 MODULE 52 Cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.626E-3 2.824E-2
1.465E-1
7.626E-1
 3 433
28 M446 MORF HAT1 Neighborhood of HAT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.227E-2 4.383E-2
2.274E-1
1.000E0
 2 174
29 M949 MODULE 244 Response to DNA damage. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.408E-2 4.856E-2
2.519E-1
1.000E0
 2 187
Show 24 more annotations

16: MicroRNA [Display Chart] 13 input genes in category / 262 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-6824-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.644E-5 9.547E-3
5.869E-2
 9.547E-3 2 50
2 hsa-miR-409-3p:Functional MTI Functional MTI miRTarbase 1.805E-4 2.364E-2
1.453E-1
 4.729E-2 2 111

17: Drug [Display Chart] 13 input genes in category / 2968 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000119315 8-oxyguanine Stitch 8.883E-27 2.637E-23 2.260E-22 2.637E-23 12 130
2 CID000002353 berberine Stitch 1.068E-25 1.080E-22 9.262E-22 3.169E-22 13 280
3 CID000004113 methoxyamine Stitch 1.092E-25 1.080E-22 9.262E-22 3.241E-22 10 46
4 CID000001135 thymine Stitch 5.096E-25 3.781E-22 3.242E-21 1.513E-21 13 315
5 CID000004156 methyl methanesulfonate Stitch 3.454E-24 2.050E-21 1.758E-20 1.025E-20 13 364
6 CID000018058 thymine glycol Stitch 3.823E-22 1.891E-19 1.621E-18 1.135E-18 9 50
7 CID000065275 O6-methylguanine Stitch 7.498E-21 3.179E-18 2.725E-17 2.225E-17 9 68
8 CID000073268 5-hydroxyuracil Stitch 2.692E-20 9.748E-18 8.357E-17 7.991E-17 8 37
9 CID000000597 cytosine Stitch 2.956E-20 9.748E-18 8.357E-17 8.774E-17 12 441
10 CID000001174 uracil Stitch 3.763E-20 1.117E-17 9.575E-17 1.117E-16 11 269
11 CID000093556 dihydrothymine Stitch 4.289E-20 1.157E-17 9.921E-17 1.273E-16 8 39
12 CID000161815 2-deoxyribonolactone Stitch 5.179E-20 1.281E-17 1.098E-16 1.537E-16 7 17
13 CID000006261 1-methyl-2-nitro-1-nitrosoguanidine Stitch 3.473E-18 7.930E-16 6.798E-15 1.031E-14 10 238
14 CID003014609 5-hydroxy-5-methylhydantoin Stitch 8.032E-18 1.703E-15 1.460E-14 2.384E-14 6 12
15 CID000104994 1,N6-ethenoadenine Stitch 1.622E-17 3.210E-15 2.752E-14 4.814E-14 8 78
16 ctd:C408982 CPG-oligonucleotide CTD 8.158E-17 1.513E-14 1.297E-13 2.421E-13 9 184
17 CID000345751 NSC403510 Stitch 1.392E-16 2.430E-14 2.083E-13 4.131E-13 8 101
18 CID000008028 tetrahydrofuran Stitch 4.071E-16 6.712E-14 5.754E-13 1.208E-12 7 53
19 CID000122328 FapyGua Stitch 6.469E-16 1.011E-13 8.663E-13 1.920E-12 6 22
20 CID000065040 5-methylcytosine Stitch 7.070E-16 1.049E-13 8.995E-13 2.098E-12 9 233
21 CID000011361 7-methylguanine Stitch 1.018E-15 1.439E-13 1.234E-12 3.022E-12 7 60
22 CID000065154 8-oxoguanine Stitch 1.458E-15 1.967E-13 1.686E-12 4.327E-12 7 63
23 CID005355054 8-hydroxyadenine Stitch 3.261E-15 4.208E-13 3.608E-12 9.679E-12 6 28
24 CID003014752 5-hydroxycytosine Stitch 4.111E-15 5.084E-13 4.358E-12 1.220E-11 6 29
25 ctd:C547185 riccardin D CTD 5.743E-15 6.818E-13 5.845E-12 1.704E-11 7 76
26 CID000114926 FapyAde Stitch 9.575E-15 1.093E-12 9.370E-12 2.842E-11 6 33
27 CID000002029 AC1L1CRO Stitch 3.312E-14 3.511E-12 3.010E-11 9.830E-11 6 40
28 CID000004578 O6-benzylguanine Stitch 3.312E-14 3.511E-12 3.010E-11 9.830E-11 6 40
29 CID000000635 deoxyribose 5-phosphate Stitch 3.879E-14 3.970E-12 3.403E-11 1.151E-10 6 41
30 CID000012699 N-methyl-N-nitrosourea Stitch 4.182E-14 4.137E-12 3.547E-11 1.241E-10 7 100
31 CID000001139 NSC46713 Stitch 5.114E-14 4.896E-12 4.197E-11 1.518E-10 8 208
32 CID000535165 formamidopyrimidine Stitch 7.019E-14 6.510E-12 5.581E-11 2.083E-10 6 45
33 CID000005955 4NQO Stitch 1.214E-13 1.092E-11 9.358E-11 3.602E-10 7 116
34 CID000150629 2-deoxyribose 5-phosphate Stitch 2.121E-13 1.852E-11 1.588E-10 6.296E-10 5 18
35 CID000005394 temozolomide Stitch 2.320E-13 1.967E-11 1.687E-10 6.885E-10 7 127
36 CID000452109 6-OxaMyr Stitch 2.492E-13 2.054E-11 1.761E-10 7.395E-10 6 55
37 CID000073318 8-OHdG Stitch 2.741E-13 2.179E-11 1.868E-10 8.134E-10 7 130
38 CID000412123 AC1L92T5 Stitch 2.790E-13 2.179E-11 1.868E-10 8.281E-10 6 56
39 CID000566657 1,2-cyclopentanedione Stitch 3.152E-13 2.399E-11 2.057E-10 9.356E-10 4 5
40 CID000164868 Tw 26 Stitch 9.453E-13 7.014E-11 6.013E-10 2.806E-9 4 6
41 CID000304590 5-formyluracil Stitch 1.313E-12 9.503E-11 8.147E-10 3.896E-9 5 25
42 CID000012001 N-nitroso-N-methylurethane Stitch 1.456E-12 1.029E-10 8.822E-10 4.322E-9 6 73
43 CID000029740 1-bromopropan-2-ol Stitch 1.625E-12 1.122E-10 9.615E-10 4.822E-9 5 26
44 CID000005155 NSC-163661 Stitch 1.722E-12 1.161E-10 9.956E-10 5.110E-9 6 75
45 CID005282473 Zinostatino Stitch 2.194E-12 1.423E-10 1.220E-9 6.513E-9 6 78
46 CID000099172 9-aminoellipticine Stitch 2.205E-12 1.423E-10 1.220E-9 6.545E-9 4 7
47 CID003084658 3'-phosphate Stitch 2.374E-12 1.499E-10 1.285E-9 7.046E-9 6 79
48 CID000002538 NSC302991 Stitch 3.619E-12 2.237E-10 1.918E-9 1.074E-8 8 353
49 CID000000529 phosphoglycolate Stitch 5.302E-12 3.212E-10 2.753E-9 1.574E-8 6 90
50 CID000000688 2'-deoxyuridine-5'-monophosphate Stitch 6.927E-12 4.112E-10 3.525E-9 2.056E-8 6 94
Show 45 more annotations

18: Disease [Display Chart] 13 input genes in category / 644 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1302401 Adenoma of large intestine DisGeNET BeFree 2.229E-16 1.435E-13 1.011E-12 1.435E-13 10 256
2 cv:C0265325 Turcot syndrome Clinical Variations 2.489E-13 8.016E-11 5.648E-10 1.603E-10 4 4
3 C0206674 Adenoma, Villous DisGeNET BeFree 6.013E-13 1.163E-10 8.192E-10 3.872E-10 5 16
4 C0265325 Turcot syndrome (disorder) DisGeNET Curated 7.222E-13 1.163E-10 8.192E-10 4.651E-10 6 47
5 OMIN:276300 MISMATCH REPAIR CANCER SYNDROME OMIM 1.244E-12 1.335E-10 9.408E-10 8.012E-10 4 5
6 C1860335 Axillary freckling DisGeNET Curated 1.244E-12 1.335E-10 9.408E-10 8.012E-10 4 5
7 C0032580 Adenomatous Polyposis Coli DisGeNET Curated 1.480E-12 1.361E-10 9.591E-10 9.529E-10 9 386
8 C0334108 Multiple polyps DisGeNET BeFree 3.351E-12 2.609E-10 1.839E-9 2.158E-9 6 60
9 C1321489 Torre-Muir syndrome DisGeNET Curated 3.731E-12 2.609E-10 1.839E-9 2.403E-9 4 6
10 C0685938 Malignant neoplasm of gastrointestinal tract DisGeNET BeFree 4.052E-12 2.609E-10 1.839E-9 2.609E-9 8 255
11 C0541912 Duodenal Cancer DisGeNET Curated 1.739E-11 9.335E-10 6.577E-9 1.120E-8 4 8
12 C0009405 Hereditary Nonpolyposis Colorectal Neoplasms DisGeNET Curated 1.739E-11 9.335E-10 6.577E-9 1.120E-8 4 8
13 C0206684 Sebaceous Adenocarcinoma DisGeNET Curated 1.950E-11 9.662E-10 6.808E-9 1.256E-8 5 30
14 C1559154 Rash and Dermatitis Adverse Event Associated with Chemoradiation DisGeNET BeFree 4.411E-11 2.029E-9 1.429E-8 2.840E-8 6 91
15 C1333990 Hereditary Nonpolyposis Colorectal Cancer DisGeNET Curated 2.050E-10 8.800E-9 6.200E-8 1.320E-7 6 117
16 C4020869 Abnormality of the abdomen DisGeNET Curated 2.481E-10 9.985E-9 7.035E-8 1.598E-7 4 14
17 C0949059 Polyp of large intestine DisGeNET Curated 7.383E-10 2.797E-8 1.971E-7 4.755E-7 5 60
18 C1333600 Hereditary Malignant Neoplasm DisGeNET BeFree 8.741E-10 3.127E-8 2.203E-7 5.629E-7 5 62
19 C0346163 Endometrioid carcinoma ovary DisGeNET BeFree 1.479E-9 4.761E-8 3.355E-7 9.522E-7 4 21
20 C1859598 ATAXIA, EARLY-ONSET, WITH OCULOMOTOR APRAXIA AND HYPOALBUMINEMIA DisGeNET Curated 1.479E-9 4.761E-8 3.355E-7 9.522E-7 4 21
21 C1833970 COLORECTAL CANCER, SOMATIC DisGeNET BeFree 1.613E-9 4.945E-8 3.484E-7 1.038E-6 3 4
22 C1862314 Basal cell nevi DisGeNET Curated 2.186E-9 6.398E-8 4.508E-7 1.408E-6 4 23
23 C0024814 Marinesco-Sjogren syndrome DisGeNET Curated 3.023E-9 8.464E-8 5.964E-7 1.947E-6 5 79
24 C4024989 Hereditary nonpolyposis colorectal carcinoma DisGeNET Curated 3.685E-9 9.889E-8 6.967E-7 2.373E-6 4 26
25 C0151740 Intracranial Hypertension DisGeNET Curated 4.324E-9 1.114E-7 7.849E-7 2.785E-6 4 27
26 C4022012 Death in early adulthood DisGeNET Curated 7.739E-9 1.917E-7 1.351E-6 4.984E-6 4 31
27 C0235782 Gallbladder Carcinoma DisGeNET BeFree 8.306E-9 1.981E-7 1.396E-6 5.349E-6 6 216
28 C0033036 Atrial Premature Complexes DisGeNET Curated 1.053E-8 2.422E-7 1.706E-6 6.780E-6 5 101
29 C0278996 Cancer of Head and Neck DisGeNET Curated 1.237E-8 2.746E-7 1.935E-6 7.965E-6 7 426
30 C0265974 Birthmark DisGeNET Curated 1.286E-8 2.760E-7 1.944E-6 8.279E-6 4 35
31 C0153426 Malignant neoplasm of duodenum DisGeNET BeFree 1.409E-8 2.927E-7 2.062E-6 9.074E-6 3 7
32 C0037286 Skin Neoplasms DisGeNET Curated 1.560E-8 3.139E-7 2.212E-6 1.005E-5 6 240
33 C0221263 Cafe-au-Lait Spots DisGeNET Curated 1.620E-8 3.162E-7 2.228E-6 1.043E-5 4 37
34 C0333983 Hyperplastic Polyp DisGeNET BeFree 1.941E-8 3.676E-7 2.590E-6 1.250E-5 5 114
35 C3469521 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) DisGeNET Curated 2.087E-8 3.841E-7 2.706E-6 1.344E-5 6 252
36 C0014474 Ependymoma DisGeNET Curated 2.513E-8 4.377E-7 3.084E-6 1.619E-5 5 120
37 C0007113 Rectal Carcinoma DisGeNET BeFree 2.515E-8 4.377E-7 3.084E-6 1.620E-5 6 260
38 C1842774 Hyperpigmented macules DisGeNET Curated 3.019E-8 5.117E-7 3.605E-6 1.944E-5 4 43
39 C0278804 Adenocarcinoma of duodenum DisGeNET Curated 3.378E-8 5.579E-7 3.931E-6 2.176E-5 3 9
40 C0750952 Biliary Tract Cancer DisGeNET BeFree 3.616E-8 5.822E-7 4.102E-6 2.329E-5 5 129
41 C0032584 polyps DisGeNET Curated 3.747E-8 5.885E-7 4.147E-6 2.413E-5 6 278
42 C0009376 Colonic Polyps DisGeNET Curated 3.987E-8 6.113E-7 4.307E-6 2.568E-5 4 46
43 C0015625 Fanconi Anemia DisGeNET Curated 4.344E-8 6.506E-7 4.584E-6 2.798E-5 6 285
44 C0677776 Hereditary Breast and Ovarian Cancer Syndrome DisGeNET Curated 5.617E-8 8.221E-7 5.792E-6 3.617E-5 4 50
45 C0346153 Breast Cancer, Familial DisGeNET Curated 6.281E-8 8.896E-7 6.267E-6 4.045E-5 5 144
46 C0017181 Gastrointestinal Hemorrhage DisGeNET Curated 6.597E-8 8.896E-7 6.267E-6 4.248E-5 4 52
47 C0007117 Basal cell carcinoma DisGeNET Curated 6.597E-8 8.896E-7 6.267E-6 4.248E-5 4 52
48 C1881254 Inverted Squamous Cell Papilloma DisGeNET BeFree 6.630E-8 8.896E-7 6.267E-6 4.270E-5 3 11
49 C0034885 Rectal Neoplasms DisGeNET Curated 7.132E-8 9.374E-7 6.604E-6 4.593E-5 4 53
50 C0206721 Inverted Papilloma DisGeNET BeFree 1.461E-7 1.881E-6 1.325E-5 9.406E-5 3 14
Show 45 more annotations