Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc243_11, positive side

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1: GO: Molecular Function [Display Chart] 11 input genes in category / 14 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003678 DNA helicase activity 6.424E-13 8.993E-12 2.924E-11 8.993E-12 6 65
2 GO:0004386 helicase activity 2.498E-10 1.749E-9 5.686E-9 3.498E-9 6 172
3 GO:0003688 DNA replication origin binding 1.277E-8 5.961E-8 1.938E-7 1.788E-7 3 9
4 GO:0003697 single-stranded DNA binding 2.915E-7 1.020E-6 3.317E-6 4.081E-6 4 104
5 GO:0004003 ATP-dependent DNA helicase activity 2.436E-6 6.821E-6 2.218E-5 3.410E-5 3 47
6 GO:0008094 DNA-dependent ATPase activity 1.921E-5 4.482E-5 1.457E-4 2.689E-4 3 93
7 GO:0070035 purine NTP-dependent helicase activity 3.353E-5 5.868E-5 1.908E-4 4.694E-4 3 112
8 GO:0008026 ATP-dependent helicase activity 3.353E-5 5.868E-5 1.908E-4 4.694E-4 3 112
9 GO:0042623 ATPase activity, coupled 8.282E-4 1.288E-3 4.189E-3 1.159E-2 3 332
10 GO:0016887 ATPase activity 1.939E-3 2.715E-3 8.828E-3 2.715E-2 3 446
11 GO:0010997 anaphase-promoting complex binding 3.532E-3 4.495E-3 1.462E-2 4.945E-2 1 6
12 GO:0000217 DNA secondary structure binding 1.464E-2 1.708E-2
5.555E-2
2.050E-1
 1 25
Show 7 more annotations

2: GO: Biological Process [Display Chart] 11 input genes in category / 83 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006270 DNA replication initiation 5.227E-24 4.339E-22 2.170E-21 4.339E-22 9 35
2 GO:0006261 DNA-dependent DNA replication 2.890E-21 1.199E-19 6.000E-19 2.399E-19 10 134
3 GO:0006260 DNA replication 7.777E-20 2.152E-18 1.076E-17 6.455E-18 11 346
4 GO:0000082 G1/S transition of mitotic cell cycle 1.527E-18 3.168E-17 1.584E-16 1.267E-16 10 247
5 GO:0044843 cell cycle G1/S phase transition 2.286E-18 3.794E-17 1.898E-16 1.897E-16 10 257
6 GO:0032508 DNA duplex unwinding 1.717E-12 2.375E-11 1.188E-10 1.425E-10 6 76
7 GO:0032392 DNA geometric change 2.546E-12 3.018E-11 1.510E-10 2.113E-10 6 81
8 GO:0006268 DNA unwinding involved in DNA replication 1.381E-11 1.432E-10 7.165E-10 1.146E-9 4 10
9 GO:0071103 DNA conformation change 5.281E-9 4.870E-8 2.436E-7 4.383E-7 6 285
10 GO:0010389 regulation of G2/M transition of mitotic cell cycle 5.695E-4 4.727E-3 2.364E-2 4.727E-2 2 61
11 GO:1902749 regulation of cell cycle G2/M phase transition 7.073E-4 5.337E-3 2.670E-2
5.871E-2
 2 68
12 GO:0000727 double-strand break repair via break-induced replication 2.361E-3 1.633E-2
8.168E-2
1.959E-1
 1 4
13 GO:0070318 positive regulation of G0 to G1 transition 2.950E-3 1.884E-2
9.422E-2
2.449E-1
 1 5
14 GO:0010571 positive regulation of nuclear cell cycle DNA replication 3.539E-3 2.098E-2
1.050E-1
2.938E-1
 1 6
15 GO:0033314 mitotic DNA replication checkpoint 4.128E-3 2.284E-2
1.143E-1
3.426E-1
 1 7
16 GO:0000086 G2/M transition of mitotic cell cycle 5.751E-3 2.865E-2
1.433E-1
4.773E-1
 2 197
17 GO:0070316 regulation of G0 to G1 transition 5.892E-3 2.865E-2
1.433E-1
4.891E-1
 1 10
18 GO:0044839 cell cycle G2/M phase transition 6.212E-3 2.865E-2
1.433E-1
5.156E-1
 2 205
19 GO:0045023 G0 to G1 transition 7.067E-3 3.087E-2
1.544E-1
5.866E-1
 1 12
20 GO:0033262 regulation of nuclear cell cycle DNA replication 7.654E-3 3.176E-2
1.589E-1
6.353E-1
 1 13
21 GO:2000105 positive regulation of DNA-dependent DNA replication 8.241E-3 3.257E-2
1.629E-1
6.840E-1
 1 14
22 GO:0000076 DNA replication checkpoint 9.413E-3 3.435E-2
1.718E-1
7.813E-1
 1 16
23 GO:0090068 positive regulation of cell cycle process 9.755E-3 3.435E-2
1.718E-1
8.097E-1
 2 259
24 GO:0018105 peptidyl-serine phosphorylation 1.012E-2 3.435E-2
1.718E-1
8.400E-1
 2 264
25 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 1.058E-2 3.435E-2
1.718E-1
8.784E-1
 1 18
26 GO:1902751 positive regulation of cell cycle G2/M phase transition 1.117E-2 3.435E-2
1.718E-1
9.270E-1
 1 19
27 GO:0018209 peptidyl-serine modification 1.117E-2 3.435E-2
1.718E-1
9.274E-1
 2 278
28 GO:1901990 regulation of mitotic cell cycle phase transition 1.444E-2 4.054E-2
2.028E-1
1.000E0
 2 318
29 GO:0044818 mitotic G2/M transition checkpoint 1.467E-2 4.054E-2
2.028E-1
1.000E0
 1 25
30 GO:0033260 nuclear DNA replication 1.467E-2 4.054E-2
2.028E-1
1.000E0
 1 25
31 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 1.584E-2 4.054E-2
2.028E-1
1.000E0
 1 27
32 GO:0071364 cellular response to epidermal growth factor stimulus 1.584E-2 4.054E-2
2.028E-1
1.000E0
 1 27
33 GO:1901987 regulation of cell cycle phase transition 1.621E-2 4.054E-2
2.028E-1
1.000E0
 2 338
34 GO:0071353 cellular response to interleukin-4 1.700E-2 4.054E-2
2.028E-1
1.000E0
 1 29
35 GO:0045787 positive regulation of cell cycle 1.750E-2 4.054E-2
2.028E-1
1.000E0
 2 352
36 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 1.758E-2 4.054E-2
2.028E-1
1.000E0
 1 30
37 GO:1902750 negative regulation of cell cycle G2/M phase transition 1.874E-2 4.094E-2
2.048E-1
1.000E0
 1 32
38 GO:0070849 response to epidermal growth factor 1.874E-2 4.094E-2
2.048E-1
1.000E0
 1 32
39 GO:0044786 cell cycle DNA replication 1.991E-2 4.130E-2
2.066E-1
1.000E0
 1 34
40 GO:0070670 response to interleukin-4 1.991E-2 4.130E-2
2.066E-1
1.000E0
 1 34
41 GO:0031572 G2 DNA damage checkpoint 2.222E-2 4.499E-2
2.250E-1
1.000E0
 1 38
Show 36 more annotations

3: GO: Cellular Component [Display Chart] 11 input genes in category / 22 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042555 MCM complex 3.203E-18 7.047E-17 2.601E-16 7.047E-17 6 11
2 GO:0000784 nuclear chromosome, telomeric region 2.214E-13 2.435E-12 8.988E-12 4.870E-12 7 133
3 GO:0000781 chromosome, telomeric region 9.018E-13 6.613E-12 2.441E-11 1.984E-11 7 162
4 GO:0098687 chromosomal region 1.820E-10 1.001E-9 3.695E-9 4.004E-9 7 344
5 GO:0005664 nuclear origin of replication recognition complex 1.199E-8 4.395E-8 1.622E-7 2.637E-7 3 9
6 GO:0000808 origin recognition complex 1.199E-8 4.395E-8 1.622E-7 2.637E-7 3 9
7 GO:0043596 nuclear replication fork 2.452E-4 7.708E-4 2.845E-3 5.395E-3 2 41
8 GO:0005657 replication fork 6.559E-4 1.804E-3 6.657E-3 1.443E-2 2 67
9 GO:0005658 alpha DNA polymerase:primase complex 2.307E-3 5.638E-3 2.081E-2
5.074E-2
 1 4
10 GO:0031298 replication fork protection complex 3.458E-3 7.608E-3 2.808E-2
7.608E-2
 1 6
11 GO:0043601 nuclear replisome 1.604E-2 3.209E-2
1.184E-1
3.530E-1
 1 28
12 GO:0030894 replisome 1.775E-2 3.254E-2
1.201E-1
3.905E-1
 1 31
13 GO:0016235 aggresome 2.002E-2 3.388E-2
1.250E-1
4.404E-1
 1 35
14 GO:0045171 intercellular bridge 2.511E-2 3.945E-2
1.456E-1
5.524E-1
 1 44
15 GO:0000785 chromatin 3.076E-2 4.511E-2
1.665E-1
6.767E-1
 2 487
Show 10 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 241 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0006628 Absent sternal ossification 5.413E-6 1.304E-3 7.910E-3 1.304E-3 2 4
2 HP:0011863 Abnormal sternal ossification 2.522E-5 2.026E-3 1.228E-2 6.077E-3 2 8
3 HP:0003561 Birth length less than 3rd percentile 2.522E-5 2.026E-3 1.228E-2 6.077E-3 2 8
4 HP:0011267 Microtia, third degree 4.947E-5 2.981E-3 1.807E-2 1.192E-2 2 11
5 HP:0009892 Anotia 8.174E-5 3.267E-3 1.981E-2 1.970E-2 2 14
6 HP:0009939 Mandibular aplasia 8.174E-5 3.267E-3 1.981E-2 1.970E-2 2 14
7 HP:0100783 Breast aplasia 1.077E-4 3.267E-3 1.981E-2 2.596E-2 2 16
8 HP:0006660 Aplastic clavicle 1.220E-4 3.267E-3 1.981E-2 2.940E-2 2 17
9 HP:0000064 Hypoplastic labia minora 1.220E-4 3.267E-3 1.981E-2 2.940E-2 2 17
10 HP:0006443 Patellar aplasia 1.702E-4 4.103E-3 2.488E-2 4.103E-2 2 20
11 HP:0006714 Aplasia/Hypoplasia of the sternum 2.469E-4 5.409E-3 3.280E-2
5.950E-2
 2 24
12 HP:0012880 Abnormality of the labia minora 2.905E-4 5.833E-3 3.537E-2
7.000E-2
 2 26
13 HP:0000059 Hypoplastic labia majora 3.375E-4 6.257E-3 3.795E-2
8.135E-2
 2 28
14 HP:0000060 Clitoral hypoplasia 4.705E-4 7.083E-3 4.295E-2
1.134E-1
 2 33
15 HP:0006498 Aplasia/Hypoplasia of the patella 4.705E-4 7.083E-3 4.295E-2
1.134E-1
 2 33
16 HP:0040255 Aplasia/Hypoplasia of the clitoris 4.705E-4 7.083E-3 4.295E-2
1.134E-1
 2 33
17 HP:0012881 Abnormality of the labia majora 4.997E-4 7.083E-3 4.295E-2
1.204E-1
 2 34
18 HP:0000898 Hypoplastic clavicles 5.606E-4 7.111E-3 4.312E-2
1.351E-1
 2 36
19 HP:0000039 Epispadias 5.606E-4 7.111E-3 4.312E-2
1.351E-1
 2 36
20 HP:0006710 Aplasia/Hypoplasia of the clavicles 6.251E-4 7.214E-3 4.375E-2
1.506E-1
 2 38
21 HP:0002970 Genu varum 6.586E-4 7.214E-3 4.375E-2
1.587E-1
 2 39
22 HP:0003187 Breast hypoplasia 6.586E-4 7.214E-3 4.375E-2
1.587E-1
 2 39
23 HP:0000066 Labial hypoplasia 6.929E-4 7.261E-3 4.403E-2
1.670E-1
 2 40
24 HP:0006591 Absent glenoid fossa 1.062E-3 1.067E-2
6.468E-2
2.560E-1
 1 1
25 HP:0012815 Hypoplastic female external genitalia 1.217E-3 1.114E-2
6.756E-2
2.934E-1
 2 53
26 HP:0000413 Atresia of the external auditory canal 1.359E-3 1.114E-2
6.756E-2
3.275E-1
 2 56
27 HP:0000176 Submucous cleft hard palate 1.559E-3 1.114E-2
6.756E-2
3.757E-1
 2 60
28 HP:0040253 Increased size of the clitoris 1.559E-3 1.114E-2
6.756E-2
3.757E-1
 2 60
29 HP:0040252 Abnormal size of the clitoris 1.559E-3 1.114E-2
6.756E-2
3.757E-1
 2 60
30 HP:0008665 Clitoral hypertrophy 1.559E-3 1.114E-2
6.756E-2
3.757E-1
 2 60
31 HP:0410031 Submucous cleft of soft and hard palate 1.559E-3 1.114E-2
6.756E-2
3.757E-1
 2 60
32 HP:0010311 Aplasia/Hypoplasia of the breasts 1.611E-3 1.114E-2
6.756E-2
3.883E-1
 2 61
33 HP:0410005 Cleft hard palate 1.611E-3 1.114E-2
6.756E-2
3.883E-1
 2 61
34 HP:0000208 Submucous cleft lip/palate 1.611E-3 1.114E-2
6.756E-2
3.883E-1
 2 61
35 HP:0000908 Hypoplastic ribs 1.664E-3 1.114E-2
6.756E-2
4.011E-1
 2 62
36 HP:0000773 Short ribs 1.664E-3 1.114E-2
6.756E-2
4.011E-1
 2 62
37 HP:0000058 Abnormality of the labia 1.828E-3 1.191E-2
7.221E-2
4.406E-1
 2 65
38 HP:0003042 Elbow dislocation 2.118E-3 1.221E-2
7.404E-2
5.105E-1
 2 70
39 HP:0025129 Abnormal small intestinal mucosa morphology 2.124E-3 1.221E-2
7.404E-2
5.118E-1
 1 2
40 HP:0000911 Flat glenoid fossa 2.124E-3 1.221E-2
7.404E-2
5.118E-1
 1 2
41 HP:0025130 Decreased small intestinal mucosa lactase activity 2.124E-3 1.221E-2
7.404E-2
5.118E-1
 1 2
42 HP:0003045 Abnormality of the patella 2.179E-3 1.221E-2
7.404E-2
5.250E-1
 2 71
43 HP:0030310 Upper extremity joint dislocation 2.179E-3 1.221E-2
7.404E-2
5.250E-1
 2 71
44 HP:0410004 Cleft secondary palate 2.240E-3 1.227E-2
7.440E-2
5.398E-1
 2 72
45 HP:0000372 Abnormality of the auditory canal 2.493E-3 1.335E-2
8.097E-2
6.009E-1
 2 76
46 HP:0003100 Slender long bone 2.625E-3 1.346E-2
8.162E-2
6.326E-1
 2 78
47 HP:0003061 Gracile long bones 2.625E-3 1.346E-2
8.162E-2
6.326E-1
 2 78
48 HP:0004789 Lactose intolerance 3.184E-3 1.599E-2
9.694E-2
7.674E-1
 1 3
49 HP:0000193 Bifid uvula 3.483E-3 1.713E-2
1.039E-1
8.393E-1
 2 90
50 HP:0006712 Aplasia/Hypoplasia of the ribs 3.794E-3 1.829E-2
1.109E-1
9.145E-1
 2 94
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 11 input genes in category / 158 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008866 chromosomal instability 8.055E-8 6.920E-6 3.905E-5 1.273E-5 5 119
2 MP:0010094 abnormal chromosome stability 8.759E-8 6.920E-6 3.905E-5 1.384E-5 5 121
3 MP:0002399 abnormal pluripotent precursor cell morphology 3.226E-7 1.699E-5 9.587E-5 5.097E-5 3 14
4 MP:0011913 abnormal reticulocyte cell number 3.757E-6 1.468E-4 8.281E-4 5.936E-4 4 110
5 MP:0002424 abnormal reticulocyte morphology 4.644E-6 1.468E-4 8.281E-4 7.338E-4 4 116
6 MP:0011091 prenatal lethality, complete penetrance 3.354E-5 8.832E-4 4.984E-3 5.299E-3 5 404
7 MP:0011101 prenatal lethality, incomplete penetrance 4.895E-5 1.105E-3 6.234E-3 7.734E-3 5 437
8 MP:0012431 increased lymphoma incidence 1.034E-4 2.043E-3 1.153E-2 1.634E-2 4 255
9 MP:0002640 reticulocytosis 1.170E-4 2.054E-3 1.159E-2 1.849E-2 3 95
10 MP:0010296 increased hemolymphoid system tumor incidence 2.067E-4 2.970E-3 1.676E-2 3.267E-2 4 305
11 MP:0013663 increased myeloid cell number 2.067E-4 2.970E-3 1.676E-2 3.267E-2 4 305
12 MP:0003077 abnormal cell cycle 2.864E-4 3.768E-3 2.126E-2 4.526E-2 4 332
13 MP:0011704 decreased fibroblast proliferation 3.100E-4 3.768E-3 2.126E-2 4.898E-2 3 132
14 MP:0008057 abnormal DNA replication 3.549E-4 4.006E-3 2.260E-2
5.608E-2
 2 27
15 MP:0011702 abnormal fibroblast proliferation 7.085E-4 7.463E-3 4.211E-2
1.119E-1
 3 175
16 MP:0020414 abnormal fibroblast physiology 2.323E-3 2.294E-2
1.294E-1
3.670E-1
 3 264
17 MP:0010288 increased gland tumor incidence 3.065E-3 2.849E-2
1.608E-1
4.843E-1
 3 291
18 MP:0002718 abnormal inner cell mass morphology 3.253E-3 2.855E-2
1.611E-1
5.139E-1
 2 82
19 MP:0002026 increased leukemia incidence 4.076E-3 3.390E-2
1.913E-1
6.441E-1
 2 92
20 MP:0010299 increased mammary gland tumor incidence 4.892E-3 3.790E-2
2.139E-1
7.730E-1
 2 101
21 MP:0002024 increased T cell derived lymphoma incidence 5.180E-3 3.790E-2
2.139E-1
8.184E-1
 2 104
22 MP:0010365 increased thymus tumor incidence 5.277E-3 3.790E-2
2.139E-1
8.338E-1
 2 105
23 MP:0014127 increased thymoma incidence 6.358E-3 4.368E-2
2.465E-1
1.000E0
 1 6
Show 18 more annotations

6: Domain [Display Chart] 11 input genes in category / 53 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR018525 MCM CS InterPro 7.698E-21 1.360E-19 6.198E-19 4.080E-19 6 6
2 PF14551 MCM N Pfam 7.698E-21 1.360E-19 6.198E-19 4.080E-19 6 6
3 IPR027925 MCM N InterPro 7.698E-21 1.360E-19 6.198E-19 4.080E-19 6 6
4 PF17207 MCM OB Pfam 2.155E-19 1.631E-18 7.434E-18 1.142E-17 6 8
5 PS50051 MCM 2 PROSITE 2.155E-19 1.631E-18 7.434E-18 1.142E-17 6 8
6 PS00847 MCM 1 PROSITE 2.155E-19 1.631E-18 7.434E-18 1.142E-17 6 8
7 IPR033762 MCM OB InterPro 2.155E-19 1.631E-18 7.434E-18 1.142E-17 6 8
8 IPR001208 MCM dom InterPro 6.462E-19 3.114E-18 1.419E-17 3.425E-17 6 9
9 IPR031327 MCM InterPro 6.462E-19 3.114E-18 1.419E-17 3.425E-17 6 9
10 PF00493 MCM Pfam 6.462E-19 3.114E-18 1.419E-17 3.425E-17 6 9
11 SM00350 MCM SMART 6.462E-19 3.114E-18 1.419E-17 3.425E-17 6 9
12 IPR012340 NA-bd OB-fold InterPro 3.074E-12 1.358E-11 6.186E-11 1.629E-10 6 84
13 IPR003593 AAA+ ATPase InterPro 1.059E-6 4.010E-6 1.827E-5 5.614E-5 4 144
14 SM00382 AAA SMART 1.059E-6 4.010E-6 1.827E-5 5.614E-5 4 144
15 2.20.28.10 - Gene3D 1.879E-6 6.225E-6 2.837E-5 9.960E-5 2 4
16 IPR004039 Rubredoxin-type fold InterPro 1.879E-6 6.225E-6 2.837E-5 9.960E-5 2 4
17 PF12619 MCM2 N Pfam 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
18 PF05460 ORC6 Pfam 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
19 PF09329 zf-primase Pfam 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
20 IPR020529 ORC6 met/pln InterPro 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
21 IPR008049 MCM6 InterPro 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
22 IPR008046 Mcm3 InterPro 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
23 PF09332 Mcm10 Pfam 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
24 PD315657 Origin recog cplx su6-like ProDom 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
25 IPR008050 MCM7 InterPro 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
26 IPR015411 Rep factor Mcm10 C InterPro 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
27 IPR008721 ORC6 InterPro 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
28 IPR008047 MCM 4 InterPro 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
29 IPR008048 MCM5 InterPro 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
30 IPR015408 Znf Mcm10/DnaG InterPro 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
31 IPR008045 MCM2 InterPro 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
32 SM01280 Mcm10 SMART 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
33 IPR024146 Claspin InterPro 5.871E-4 9.430E-4 4.297E-3 3.112E-2 1 1
34 IPR015163 Cdc6 C InterPro 1.174E-3 1.728E-3 7.876E-3
6.222E-2
 1 2
35 SM01074 Cdc6 C SMART 1.174E-3 1.728E-3 7.876E-3
6.222E-2
 1 2
36 PF09079 Cdc6 C Pfam 1.174E-3 1.728E-3 7.876E-3
6.222E-2
 1 2
37 SM00439 BAH SMART 6.441E-3 8.535E-3 3.889E-2
3.414E-1
 1 11
38 PF01426 BAH Pfam 6.441E-3 8.535E-3 3.889E-2
3.414E-1
 1 11
39 PS51038 BAH PROSITE 6.441E-3 8.535E-3 3.889E-2
3.414E-1
 1 11
40 IPR001025 BAH dom InterPro 6.441E-3 8.535E-3 3.889E-2
3.414E-1
 1 11
41 IPR013763 Cyclin-like InterPro 2.497E-2 3.227E-2
1.471E-1
1.000E0
 1 43
42 PF00004 AAA Pfam 3.012E-2 3.801E-2
1.732E-1
1.000E0
 1 52
43 IPR003959 ATPase AAA core InterPro 3.126E-2 3.853E-2
1.756E-1
1.000E0
 1 54
Show 38 more annotations

7: Pathway [Display Chart] 11 input genes in category / 42 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269757 Activation of ATR in response to replication stress BioSystems: REACTOME 3.077E-29 1.292E-27 5.592E-27 1.292E-27 11 37
2 1269773 Activation of the pre-replicative complex BioSystems: REACTOME 2.884E-26 6.056E-25 2.620E-24 1.211E-24 10 32
3 M6682 CDK Regulation of DNA Replication MSigDB C2 BIOCARTA (v6.0) 5.044E-22 7.061E-21 3.055E-20 2.118E-20 8 18
4 1269832 DNA Replication Pre-Initiation BioSystems: REACTOME 2.009E-21 1.688E-20 7.303E-20 8.440E-20 10 88
5 1269831 M/G1 Transition BioSystems: REACTOME 2.009E-21 1.688E-20 7.303E-20 8.440E-20 10 88
6 1269753 G2/M Checkpoints BioSystems: REACTOME 2.536E-21 1.775E-20 7.680E-20 1.065E-19 11 172
7 1269742 Cell Cycle Checkpoints BioSystems: REACTOME 1.745E-20 1.047E-19 4.531E-19 7.330E-19 11 204
8 1269875 DNA Replication BioSystems: REACTOME 2.291E-20 1.203E-19 5.203E-19 9.621E-19 10 111
9 1269768 G1/S Transition BioSystems: REACTOME 5.619E-20 2.622E-19 1.135E-18 2.360E-18 10 121
10 1269764 Mitotic G1-G1/S phases BioSystems: REACTOME 3.654E-19 1.500E-18 6.492E-18 1.535E-17 10 145
11 1269796 Removal of licensing factors from origins BioSystems: REACTOME 3.930E-19 1.500E-18 6.492E-18 1.650E-17 9 76
12 1269794 Regulation of DNA replication BioSystems: REACTOME 5.674E-19 1.986E-18 8.593E-18 2.383E-17 9 79
13 83054 Cell cycle BioSystems: KEGG 3.887E-17 1.256E-16 5.433E-16 1.632E-15 9 124
14 1269785 Unwinding of DNA BioSystems: REACTOME 8.246E-17 2.474E-16 1.070E-15 3.463E-15 6 12
15 1269833 Assembly of the pre-replicative complex BioSystems: REACTOME 1.212E-16 3.395E-16 1.469E-15 5.092E-15 8 71
16 1269781 Switching of origins to a post-replicative state BioSystems: REACTOME 1.716E-16 4.241E-16 1.835E-15 7.209E-15 8 74
17 1269782 Orc1 removal from chromatin BioSystems: REACTOME 1.716E-16 4.241E-16 1.835E-15 7.209E-15 8 74
18 1269779 Synthesis of DNA BioSystems: REACTOME 2.691E-15 6.279E-15 2.717E-14 1.130E-13 8 103
19 1269777 S Phase BioSystems: REACTOME 2.071E-14 4.578E-14 1.981E-13 8.698E-13 8 132
20 1269784 DNA strand elongation BioSystems: REACTOME 8.032E-14 1.687E-13 7.298E-13 3.373E-12 6 32
21 83039 DNA replication BioSystems: KEGG 1.724E-13 3.448E-13 1.492E-12 7.241E-12 6 36
22 1269834 Assembly of the ORC complex at the origin of replication BioSystems: REACTOME 1.063E-5 2.028E-5 8.777E-5 4.463E-4 2 6
23 1269776 E2F-enabled inhibition of pre-replication complex formation BioSystems: REACTOME 3.181E-5 5.810E-5 2.514E-4 1.336E-3 2 10
24 1269835 CDC6 association with the ORC:origin complex BioSystems: REACTOME 3.887E-5 6.802E-5 2.943E-4 1.632E-3 2 11
25 1269774 E2F mediated regulation of DNA replication BioSystems: REACTOME 3.921E-4 6.587E-4 2.850E-3 1.647E-2 2 34
26 1269836 CDT1 association with the CDC6:ORC:origin complex BioSystems: REACTOME 1.304E-3 2.106E-3 9.113E-3
5.476E-2
 2 62
27 137934 E2F transcription factor network BioSystems: Pathway Interaction Database 1.802E-3 2.804E-3 1.213E-2
7.570E-2
 2 73
28 1269795 Association of licensing factors with the pre-replicative complex BioSystems: REACTOME 1.318E-2 1.977E-2
8.553E-2
5.535E-1
 1 15
29 1269772 G1/S-Specific Transcription BioSystems: REACTOME 1.580E-2 2.288E-2
9.898E-2
6.634E-1
 1 18
30 1270288 Apoptotic cleavage of cellular proteins BioSystems: REACTOME 3.394E-2 4.751E-2
2.056E-1
1.000E0
 1 39
Show 25 more annotations

8: Pubmed [Display Chart] 11 input genes in category / 812 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15226314 Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures. Pubmed 1.198E-38 9.726E-36 7.078E-35 9.726E-36 11 19
2 15707391 DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. Pubmed 1.118E-37 4.539E-35 3.303E-34 9.078E-35 11 22
3 15232106 Self-assembling protein microarrays. Pubmed 1.817E-31 4.918E-29 3.579E-28 1.476E-28 10 30
4 12791985 Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Pubmed 7.930E-31 1.610E-28 1.172E-27 6.439E-28 10 34
5 11095689 The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. Pubmed 1.321E-30 2.146E-28 1.561E-27 1.073E-27 9 16
6 12045100 DNA replication in eukaryotic cells. Pubmed 5.615E-30 7.598E-28 5.530E-27 4.559E-27 9 18
7 12614612 Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. Pubmed 1.939E-29 2.250E-27 1.637E-26 1.575E-26 9 20
8 10436018 The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells. Pubmed 9.458E-27 9.600E-25 6.986E-24 7.680E-24 8 15
9 16899510 Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. Pubmed 1.123E-25 1.013E-23 7.373E-23 9.118E-23 7 8
10 10846177 Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks. Pubmed 5.053E-25 4.103E-23 2.986E-22 4.103E-22 7 9
11 11931757 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Pubmed 2.294E-24 1.694E-22 1.233E-21 1.863E-21 8 26
12 22540012 Interactions of the human MCM-BP protein with MCM complex components and Dbf4. Pubmed 1.111E-23 6.941E-22 5.051E-21 9.024E-21 7 12
13 24299456 Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7. Pubmed 1.111E-23 6.941E-22 5.051E-21 9.024E-21 7 12
14 15236977 Pairwise interactions of the six human MCM protein subunits. Pubmed 1.072E-22 5.121E-21 3.727E-20 8.706E-20 6 6
15 9099751 In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP. Pubmed 1.072E-22 5.121E-21 3.727E-20 8.706E-20 6 6
16 22918583 The eukaryotic Mcm2-7 replicative helicase. Pubmed 1.072E-22 5.121E-21 3.727E-20 8.706E-20 6 6
17 21220507 Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload. Pubmed 1.072E-22 5.121E-21 3.727E-20 8.706E-20 6 6
18 17296731 Identification and characterization of a novel component of the human minichromosome maintenance complex. Pubmed 7.504E-22 3.047E-20 2.217E-19 6.093E-19 6 7
19 8798650 Binding of human minichromosome maintenance proteins with histone H3. Pubmed 7.504E-22 3.047E-20 2.217E-19 6.093E-19 6 7
20 11248027 Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma. Pubmed 7.504E-22 3.047E-20 2.217E-19 6.093E-19 6 7
21 23993743 FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling. Pubmed 3.001E-21 1.160E-19 8.445E-19 2.437E-18 6 8
22 21149733 L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability. Pubmed 9.003E-21 3.323E-19 2.418E-18 7.310E-18 6 9
23 21055985 A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Pubmed 2.250E-20 7.614E-19 5.541E-18 1.827E-17 6 10
24 16902406 Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication. Pubmed 2.250E-20 7.614E-19 5.541E-18 1.827E-17 6 10
25 20838603 Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress. Pubmed 6.824E-19 2.216E-17 1.613E-16 5.541E-16 5 5
26 20808282 A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus. Pubmed 1.080E-17 3.374E-16 2.455E-15 8.771E-15 6 23
27 23764002 Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Pubmed 1.433E-17 4.155E-16 3.023E-15 1.163E-14 5 7
28 12364596 Human Mcm proteins at a replication origin during the G1 to S phase transition. Pubmed 1.433E-17 4.155E-16 3.023E-15 1.163E-14 5 7
29 19135898 Purification of proteins associated with specific genomic Loci. Pubmed 3.050E-17 8.539E-16 6.214E-15 2.476E-14 7 76
30 19862764 Analysis of interaction partners of H4 histone by a new proteomics approach. Pubmed 3.166E-17 8.570E-16 6.236E-15 2.571E-14 6 27
31 27621311 Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate. Pubmed 5.080E-17 1.331E-15 9.683E-15 4.125E-14 6 29
32 10567526 Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity. Pubmed 3.723E-15 8.397E-14 6.111E-13 3.023E-12 4 4
33 12694531 Mammalian Mcm2/4/6/7 complex forms a toroidal structure. Pubmed 3.723E-15 8.397E-14 6.111E-13 3.023E-12 4 4
34 8265339 The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins. Pubmed 3.723E-15 8.397E-14 6.111E-13 3.023E-12 4 4
35 12207017 Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex. Pubmed 3.723E-15 8.397E-14 6.111E-13 3.023E-12 4 4
36 20421204 Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex. Pubmed 3.723E-15 8.397E-14 6.111E-13 3.023E-12 4 4
37 10748114 Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2. Pubmed 1.861E-14 4.084E-13 2.972E-12 1.511E-11 4 5
38 24190967 A role for USP7 in DNA replication. Pubmed 5.582E-14 1.193E-12 8.681E-12 4.533E-11 4 6
39 12519773 The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding. Pubmed 1.302E-13 2.712E-12 1.973E-11 1.058E-10 4 7
40 20508983 Centrosome-related genes, genetic variation, and risk of breast cancer. Pubmed 1.428E-13 2.899E-12 2.110E-11 1.160E-10 6 102
41 10523313 Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. Pubmed 2.604E-13 5.158E-12 3.754E-11 2.115E-10 4 8
42 26527279 Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. Pubmed 4.882E-12 9.363E-11 6.813E-10 3.964E-9 6 182
43 10454562 MCM proteins are associated with RNA polymerase II holoenzyme. Pubmed 5.073E-12 9.363E-11 6.813E-10 4.120E-9 4 15
44 22407294 Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. Pubmed 5.073E-12 9.363E-11 6.813E-10 4.120E-9 4 15
45 25661590 G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex. Pubmed 1.777E-11 2.488E-10 1.811E-9 1.443E-8 3 3
46 7601140 A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins. Pubmed 1.777E-11 2.488E-10 1.811E-9 1.443E-8 3 3
47 19318354 The minichromosome maintenance proteins 2-7 (MCM2-7) are necessary for RNA polymerase II (Pol II)-mediated transcription. Pubmed 1.777E-11 2.488E-10 1.811E-9 1.443E-8 3 3
48 7610039 Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: physical interaction between P1(MCM3) and CDC46 proteins. Pubmed 1.777E-11 2.488E-10 1.811E-9 1.443E-8 3 3
49 9305914 A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. Pubmed 1.777E-11 2.488E-10 1.811E-9 1.443E-8 3 3
50 9077461 Mouse MCM proteins: complex formation and transportation to the nucleus. Pubmed 1.777E-11 2.488E-10 1.811E-9 1.443E-8 3 3
Show 45 more annotations

9: Interaction [Display Chart] 11 input genes in category / 1278 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CDC7 CDC7 interactions 1.730E-30 2.210E-27 1.709E-26 2.210E-27 11 40
2 int:DBF4 DBF4 interactions 7.452E-22 4.762E-19 3.681E-18 9.523E-19 8 25
3 int:MCM6 MCM6 interactions 2.147E-21 9.148E-19 7.072E-18 2.744E-18 10 124
4 int:ORC2 ORC2 interactions 5.737E-21 1.541E-18 1.192E-17 7.331E-18 9 68
5 int:MCM4 MCM4 interactions 6.030E-21 1.541E-18 1.192E-17 7.706E-18 10 137
6 int:MCM7 MCM7 interactions 3.097E-19 6.596E-17 5.099E-16 3.958E-16 10 201
7 int:ORC5 ORC5 interactions 3.685E-19 6.728E-17 5.201E-16 4.709E-16 8 50
8 int:ORC4 ORC4 interactions 4.370E-19 6.981E-17 5.397E-16 5.585E-16 8 51
9 int:ORC6 ORC6 interactions 1.299E-17 1.844E-15 1.426E-14 1.660E-14 7 33
10 int:CDC45 CDC45 interactions 4.671E-17 5.969E-15 4.614E-14 5.969E-14 7 39
11 int:ORC1 ORC1 interactions 5.362E-16 6.229E-14 4.816E-13 6.852E-13 7 54
12 int:MCMBP MCMBP interactions 7.019E-16 7.475E-14 5.779E-13 8.970E-13 7 56
13 int:MCM5 MCM5 interactions 1.289E-15 1.267E-13 9.796E-13 1.647E-12 9 256
14 int:MCM10 MCM10 interactions 1.672E-15 1.526E-13 1.180E-12 2.137E-12 7 63
15 int:MCM3 MCM3 interactions 4.896E-15 4.171E-13 3.225E-12 6.257E-12 8 156
16 int:CDC6 CDC6 interactions 1.047E-14 8.364E-13 6.466E-12 1.338E-11 7 81
17 int:TONSL TONSL interactions 2.091E-14 1.572E-12 1.215E-11 2.673E-11 6 36
18 int:ORC3 ORC3 interactions 1.003E-13 7.124E-12 5.507E-11 1.282E-10 6 46
19 int:ASF1B ASF1B interactions 4.323E-13 2.908E-11 2.248E-10 5.525E-10 6 58
20 int:L3MBTL1 L3MBTL1 interactions 7.062E-12 4.513E-10 3.489E-9 9.026E-9 6 91
21 int:SSRP1 SSRP1 interactions 1.376E-10 8.376E-9 6.475E-8 1.759E-7 6 148
22 int:CAP1 CAP1 interactions 1.868E-10 1.085E-8 8.389E-8 2.387E-7 5 61
23 int:CDT1 CDT1 interactions 2.802E-10 1.557E-8 1.204E-7 3.581E-7 5 66
24 int:HIST1H4A HIST1H4A interactions 7.527E-10 4.008E-8 3.099E-7 9.620E-7 6 196
25 int:HIST1H3E HIST1H3E interactions 9.301E-10 4.754E-8 3.675E-7 1.189E-6 6 203
26 int:MMS22L MMS22L interactions 1.405E-9 6.908E-8 5.340E-7 1.796E-6 4 27
27 int:TIPIN TIPIN interactions 1.901E-9 8.997E-8 6.955E-7 2.429E-6 4 29
28 int:HIST1H2BA HIST1H2BA interactions 2.110E-9 9.632E-8 7.446E-7 2.697E-6 5 98
29 int:PLK1 PLK1 interactions 6.146E-9 2.709E-7 2.094E-6 7.855E-6 6 278
30 int:CCND1 CCND1 interactions 6.667E-9 2.840E-7 2.196E-6 8.520E-6 5 123
31 int:ILF2 ILF2 interactions 1.249E-8 5.149E-7 3.980E-6 1.596E-5 6 313
32 int:GINS4 GINS4 interactions 2.151E-8 8.590E-7 6.641E-6 2.749E-5 4 52
33 int:HDAC5 HDAC5 interactions 2.736E-8 1.060E-6 8.193E-6 3.497E-5 6 357
34 int:ING5 ING5 interactions 3.364E-8 1.265E-6 9.776E-6 4.300E-5 4 58
35 int:TIMELESS TIMELESS interactions 9.078E-8 3.315E-6 2.563E-5 1.160E-4 4 74
36 int:VCAM1 VCAM1 interactions 1.170E-7 4.155E-6 3.212E-5 1.496E-4 6 456
37 int:CDKN2A CDKN2A interactions 1.347E-7 4.653E-6 3.597E-5 1.722E-4 5 224
38 int:ASF1A ASF1A interactions 1.669E-7 5.604E-6 4.332E-5 2.133E-4 4 86
39 int:SF3A1 SF3A1 interactions 1.710E-7 5.604E-6 4.332E-5 2.186E-4 5 235
40 int:RPA1 RPA1 interactions 1.948E-7 6.223E-6 4.810E-5 2.489E-4 6 497
41 int:RELCH RELCH interactions 2.023E-7 6.305E-6 4.875E-5 2.585E-4 3 20
42 int:SPAG9 SPAG9 interactions 2.391E-7 7.275E-6 5.624E-5 3.055E-4 4 94
43 int:HIST2H2BF HIST2H2BF interactions 2.731E-7 7.755E-6 5.996E-5 3.490E-4 3 22
44 int:SBNO1 SBNO1 interactions 2.731E-7 7.755E-6 5.996E-5 3.490E-4 3 22
45 int:CCL2 CCL2 interactions 2.731E-7 7.755E-6 5.996E-5 3.490E-4 3 22
46 int:SPIN2B SPIN2B interactions 3.587E-7 9.965E-6 7.703E-5 4.584E-4 3 24
47 int:SF3B1 SF3B1 interactions 4.858E-7 1.321E-5 1.021E-4 6.208E-4 5 290
48 int:HIST1H3A HIST1H3A interactions 7.663E-7 2.026E-5 1.566E-4 9.794E-4 5 318
49 int:SENP3 SENP3 interactions 7.767E-7 2.026E-5 1.566E-4 9.927E-4 4 126
50 int:ATG2B ATG2B interactions 7.946E-7 2.031E-5 1.570E-4 1.016E-3 3 31
Show 45 more annotations

10: Cytoband [Display Chart] 11 input genes in category / 11 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 8q11.2 8q11.2 1.586E-3 6.977E-3 2.107E-2 1.744E-2 1 5
2 16q12 16q12 1.903E-3 6.977E-3 2.107E-2 2.093E-2 1 6
3 7q21.3-q22.1 7q21.3-q22.1 1.903E-3 6.977E-3 2.107E-2 2.093E-2 1 6
4 2q21 2q21 5.067E-3 1.160E-2 3.504E-2
5.573E-2
 1 16
5 6p12 6p12 5.383E-3 1.160E-2 3.504E-2
5.921E-2
 1 17
6 1p22 1p22 6.330E-3 1.160E-2 3.504E-2
6.963E-2
 1 20
7 3q21 3q21 7.591E-3 1.174E-2 3.545E-2
8.351E-2
 1 24
8 1p32 1p32 8.537E-3 1.174E-2 3.545E-2
9.390E-2
 1 27
9 10p13 10p13 1.450E-2 1.773E-2
5.353E-2
1.595E-1
 1 46
10 1p34.2 1p34.2 1.826E-2 2.008E-2
6.064E-2
2.008E-1
 1 58
11 22q13.1 22q13.1 2.789E-2 2.789E-2
8.422E-2
3.068E-1
 1 89
Show 6 more annotations

11: Transcription Factor Binding Site [Display Chart] 9 input genes in category / 52 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$E2F1 Q6 V$E2F1 Q6 2.328E-11 8.224E-10 3.732E-9 1.211E-9 7 181
2 V$E2F1 Q6 01 V$E2F1 Q6 01 3.163E-11 8.224E-10 3.732E-9 1.645E-9 7 189
3 SGCGSSAAA V$E2F1DP2 01 SGCGSSAAA V$E2F1DP2 01 4.211E-10 7.299E-9 3.312E-8 2.190E-8 6 131
4 V$E2F Q3 V$E2F Q3 2.609E-9 1.432E-8 6.498E-8 1.357E-7 6 177
5 V$E2F Q6 V$E2F Q6 3.087E-9 1.432E-8 6.498E-8 1.605E-7 6 182
6 V$E2F1DP2 01 V$E2F1DP2 01 3.298E-9 1.432E-8 6.498E-8 1.715E-7 6 184
7 V$E2F 02 V$E2F 02 3.298E-9 1.432E-8 6.498E-8 1.715E-7 6 184
8 V$E2F Q4 V$E2F Q4 3.298E-9 1.432E-8 6.498E-8 1.715E-7 6 184
9 V$E2F4DP2 01 V$E2F4DP2 01 3.298E-9 1.432E-8 6.498E-8 1.715E-7 6 184
10 V$E2F Q6 01 V$E2F Q6 01 3.298E-9 1.432E-8 6.498E-8 1.715E-7 6 184
11 V$E2F1DP1 01 V$E2F1DP1 01 3.298E-9 1.432E-8 6.498E-8 1.715E-7 6 184
12 V$E2F Q4 01 V$E2F Q4 01 3.407E-9 1.432E-8 6.498E-8 1.772E-7 6 185
13 V$E2F4DP1 01 V$E2F4DP1 01 3.877E-9 1.432E-8 6.498E-8 2.016E-7 6 189
14 V$E2F1 Q3 V$E2F1 Q3 4.002E-9 1.432E-8 6.498E-8 2.081E-7 6 190
15 V$E2F 03 V$E2F 03 4.131E-9 1.432E-8 6.498E-8 2.148E-7 6 191
16 KTGGYRSGAA UNKNOWN KTGGYRSGAA UNKNOWN 1.109E-7 3.605E-7 1.636E-6 5.768E-6 4 55
17 V$E2F1 Q4 01 V$E2F1 Q4 01 2.451E-7 7.496E-7 3.402E-6 1.274E-5 5 181
18 V$E2F1DP1RB 01 V$E2F1DP1RB 01 2.660E-7 7.684E-7 3.487E-6 1.383E-5 5 184
19 V$E2F Q3 01 V$E2F Q3 01 2.808E-7 7.684E-7 3.487E-6 1.460E-5 5 186
20 V$E2F 01 V$E2F 01 1.385E-5 3.600E-5 1.634E-4 7.200E-4 3 55
21 V$E2F1 Q4 V$E2F1 Q4 1.225E-2 3.035E-2
1.377E-1
6.373E-1
 2 189
22 V$FOXO1 01 V$FOXO1 01 1.379E-2 3.258E-2
1.479E-1
7.168E-1
 2 201
Show 17 more annotations

12: Gene Family [Display Chart] 8 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1085 MCM family genenames.org 4.671E-20 1.869E-19 3.893E-19 1.869E-19 6 9
2 960 Origin recognition complex genenames.org 2.536E-6 5.071E-6 1.056E-5 1.014E-5 2 6
3 413 AAA ATPases genenames.org 2.307E-2 3.076E-2
6.409E-2
9.229E-2
 1 53

13: Coexpression [Display Chart] 11 input genes in category / 1343 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20548326-Table4 Human Stomach Bonelli10 61genes GeneSigDB 2.063E-19 2.770E-16 2.155E-15 2.770E-16 8 60
2 M9372 Genes involved in DNA replication, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.723E-19 4.515E-16 3.513E-15 9.029E-16 9 146
3 15374877-Table2 Human StemCell Manalo05 108genes GeneSigDB 2.587E-18 1.158E-15 9.010E-15 3.474E-15 8 81
4 17145885-SuppTable2 Human Lung Kobayashi06 320genes GeneSigDB 8.403E-17 2.178E-14 1.694E-13 1.129E-13 9 247
5 18218118-Table1 Mouse Pancreas Thakur08 75genes GeneSigDB 9.449E-17 2.178E-14 1.694E-13 1.269E-13 7 55
6 M16010 Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.730E-17 2.178E-14 1.694E-13 1.307E-13 9 251
7 M4455 RB1 [GeneID=5925] target genes involved in cell cycle regulation: genes down-regulated by doxorubicin [PubChem=31703] only in cells expressing RB1. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.183E-16 4.189E-14 3.259E-13 2.932E-13 6 23
8 M19048 Genes down-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.679E-16 4.497E-14 3.499E-13 3.598E-13 8 142
9 M123 Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells, embryonical carcinomas and induced pluripotent cells). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.794E-16 7.153E-14 5.565E-13 6.438E-13 9 299
10 M4288 Genes up-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.856E-15 2.493E-13 1.939E-12 2.493E-12 8 180
11 18427120-DataS4 Human Breast Crawford08 971genes GeneSigDB 2.590E-15 3.162E-13 2.460E-12 3.478E-12 9 360
12 17471573-Table2 Human Viral Santegoets07 103genes GeneSigDB 2.941E-15 3.292E-13 2.561E-12 3.950E-12 7 88
13 M2132 Genes down-regulated in RS4;11 cells (MLL, mixed lineage leukemia) in response to SB216763 [PubChem=176158], an inhibitor of GSK3B [GeneID=2932]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.661E-15 3.782E-13 2.942E-12 4.916E-12 9 374
14 M1577 Strongly up-regulated at 16-24 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.953E-15 7.410E-13 5.765E-12 1.068E-11 7 101
15 17510386-Table4 Human HeadandNeck Pyeon07 42genes GeneSigDB 8.276E-15 7.410E-13 5.765E-12 1.111E-11 6 40
16 20630075-AF-2 Mouse StemCell GarciaEscudero10 371genes p53 GeneSigDB 4.268E-14 3.583E-12 2.787E-11 5.732E-11 8 265
17 M1915 Genes down-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.103E-14 4.821E-12 3.751E-11 8.196E-11 8 277
18 M18562 Genes down-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.593E-14 6.411E-12 4.988E-11 1.154E-10 8 289
19 M2156 Genes up-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChem=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.159E-13 1.526E-11 1.187E-10 2.899E-10 8 324
20 M1871 Set 'ES exp1': genes overexpressed in human embryonic stem cells according to 5 or more out of 20 profiling studies. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.615E-13 5.113E-11 3.978E-10 1.023E-9 8 379
21 M4533 Genes down-regulated in comparison of unstimulated NK cells versus those stimulated with IL2 [GeneID=3600] at 16 h. MSigDB C7: Immunologic Signatures (v6.0) 1.040E-12 6.292E-11 4.896E-10 1.397E-9 7 200
22 M5925 Genes encoding cell cycle related targets of E2F transcription factors. MSigDB H: Hallmark Gene Sets (v6.0) 1.040E-12 6.292E-11 4.896E-10 1.397E-9 7 200
23 M14340 Genes down-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [GeneID=4904] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.078E-12 6.292E-11 4.896E-10 1.447E-9 7 201
24 M2151 Genes up-regulated in MCF7 cells (breast cancer) at 6 h of estradiol [PubChem=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.709E-12 1.516E-10 1.179E-9 3.638E-9 7 229
25 18231642-TableW1 Mouse Brain DeSmaele07 122genes GeneSigDB 3.428E-12 1.842E-10 1.433E-9 4.604E-9 6 105
26 15489886-TableS1b Human Sarcoma Mason04 549genes GeneSigDB 3.858E-12 1.993E-10 1.550E-9 5.181E-9 8 464
27 M1681 Cluster 4: genes maximally expressed at 16 h time point during differentiation of 3T3-L1 fibroblasts into adipocytes in response to adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.463E-12 2.717E-10 2.114E-9 7.337E-9 5 40
28 18547747-Table1 Human Leukemia Mollinedo08 117genes GeneSigDB 6.648E-12 3.189E-10 2.481E-9 8.928E-9 6 117
29 16919171-Table3 Human Colon Ancona06 45genes GeneSigDB 7.059E-12 3.269E-10 2.543E-9 9.481E-9 5 42
30 17072343-Table1 Human Ovarian Basaki07 46genes YB-1infected GeneSigDB 1.013E-11 4.536E-10 3.529E-9 1.361E-8 5 45
31 M14985 Genes up-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.429E-11 6.193E-10 4.818E-9 1.920E-8 7 290
32 M11250 Genes down-regulated in MCF-7 cells (breast cancer) by selective estrogen receptor modulators (SERM) 4-hydroxytamoxifen, raloxifene, or ICI 182780 but not by estradiol [PubChem=44959;5035;3478439;5757]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.755E-11 7.366E-10 5.731E-9 2.357E-8 5 50
33 M2074 Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the G1/S phase of cell cycle. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.671E-11 1.087E-9 8.458E-9 3.588E-8 6 147
34 M10169 Genes downstream of both CDKN1A and TP53 [GeneID=1026;7157] in 2774qw1 cells (ovarian cancer). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.879E-11 1.137E-9 8.847E-9 3.866E-8 5 55
35 M2180 The XPRSS-Int network genes up-regulated in breast tumors from patients with germline mutations in BRCA1 [GeneID=672] compared to those with the wild type allele. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.160E-11 1.213E-9 9.435E-9 4.244E-8 5 56
36 17150101-TableS1l Human Breast Troester06 436genes-up-DOX-ZR75-1 GeneSigDB 3.467E-11 1.293E-9 1.006E-8 4.656E-8 7 329
37 M7079 The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.935E-11 1.428E-9 1.111E-8 5.285E-8 7 335
38 19139136-TableS2 Human Prostate John-Aryankalayil09 450genes GeneSigDB 4.277E-11 1.490E-9 1.159E-8 5.744E-8 7 339
39 17804718-HumanGeneList Human Breast Deeb07 61genesHumanGeneListHumanGeneList GeneSigDB 4.515E-11 1.490E-9 1.159E-8 6.063E-8 5 60
40 M2257 Cellular genes up-regulated in forskin fibroblasts by expression of CMV EI86 protein off an adenovirus vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.515E-11 1.490E-9 1.159E-8 6.063E-8 5 60
41 M2879 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.549E-11 1.490E-9 1.159E-8 6.110E-8 7 342
42 18662380-S3-AURKA Human Breast Wirapati08 355genes AURKA Module GeneSigDB 4.739E-11 1.515E-9 1.179E-8 6.365E-8 7 344
43 M2431 DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.917E-11 1.536E-9 1.195E-8 6.603E-8 5 61
44 14750170-Table2 Mouse Intestine DeGiovanni04 68genes GeneSigDB 6.820E-11 2.082E-9 1.620E-8 9.160E-8 5 65
45 M2961 Genes down-regulated in natural T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 9.122E-11 2.723E-9 2.118E-8 1.225E-7 6 180
46 M2984 Genes up-regulated in B lymphocytes: control versus stimulated by anti-IgM for 12h. MSigDB C7: Immunologic Signatures (v6.0) 9.753E-11 2.847E-9 2.215E-8 1.310E-7 6 182
47 M16458 Selected gradually up-regulated genes in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.627E-10 4.586E-9 3.568E-8 2.185E-7 5 77
48 15150092-Table1 Human StemCell Medjkane04 23genes GeneSigDB 1.648E-10 4.586E-9 3.568E-8 2.213E-7 4 21
49 M3171 Genes up-regulated in comparison of germinal center B cells versus memory B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.673E-10 4.586E-9 3.568E-8 2.247E-7 6 199
50 M5901 Genes involved in the G2/M checkpoint, as in progression through the cell division cycle. MSigDB H: Hallmark Gene Sets (v6.0) 1.725E-10 4.633E-9 3.604E-8 2.316E-7 6 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 11 input genes in category / 599 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM538387 500 alpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 8.986E-20 3.250E-17 2.266E-16 5.383E-17 11 410
2 GSM399403 500 alpha beta T cells, T.ISP.Th, 4- 8+ TCR-/lo 24hi, Thymus, avg-3 Immgen.org, GSE15907 1.085E-19 3.250E-17 2.266E-16 6.499E-17 11 417
3 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes BrainMap 4.326E-18 5.183E-16 3.614E-15 2.591E-15 10 320
4 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200 4.326E-18 5.183E-16 3.614E-15 2.591E-15 10 320
5 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes 4.326E-18 5.183E-16 3.614E-15 2.591E-15 10 320
6 GSM791143 500 alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 3.830E-17 3.823E-15 2.666E-14 2.294E-14 10 397
7 GSM399452 500 B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3 Immgen.org, GSE15907 5.173E-17 4.427E-15 3.087E-14 3.099E-14 10 409
8 GSM538348 500 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-2 Immgen.org, GSE15907 6.601E-17 4.500E-15 3.138E-14 3.954E-14 10 419
9 GSM791141 500 alpha beta T cells, preT.DN2B.Th, Lin-/lo CD25hi CD44+ cKitint, Thymus, avg-2 Immgen.org, GSE15907 6.762E-17 4.500E-15 3.138E-14 4.050E-14 10 420
10 GSM791154 500 alpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 6.476E-15 3.879E-13 2.705E-12 3.879E-12 9 376
11 GSM538207 500 B cells, B.GC.Sp, CD19+ IgM+ IgD- GL7+ PNA+, Spleen, avg-3 Immgen.org, GSE15907 7.128E-15 3.882E-13 2.707E-12 4.270E-12 9 380
12 GSM538358 500 B cells, proB.FrBC.FL, CD19+ IgM- CD43+ CD24+ AA4.1+ CD45R+, Fetal Liver, avg-3 Immgen.org, GSE15907 1.135E-14 5.663E-13 3.949E-12 6.796E-12 9 400
13 GSM476660 500 gamma delta T cells, Tgd.vg2+24ahi.e17.Th, TCRd+ Vg2+ CD24+, Fetal Thymus, avg-3 Immgen.org, GSE15907 1.549E-14 6.491E-13 4.527E-12 9.280E-12 9 414
14 GSM476664 500 gamma delta T cells, Tgd.vg3+24alo.e17.Th, TCRd+ Vg3+ CD24-, Fetal Thymus, avg-3 Immgen.org, GSE15907 1.727E-14 6.491E-13 4.527E-12 1.035E-11 9 419
15 GSM791136 500 alpha beta T cells, preT.DN2.Th, Lin-/lo CD25hi CD44+ cKit+, Thymus, avg-3 Immgen.org, GSE15907 1.765E-14 6.491E-13 4.527E-12 1.057E-11 9 420
16 GSM538355 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R+ CD, Fetal Liver, avg-2 Immgen.org, GSE15907 1.842E-14 6.491E-13 4.527E-12 1.104E-11 9 422
17 GSM538357 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 1.842E-14 6.491E-13 4.527E-12 1.104E-11 9 422
18 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr.Dlx1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr.Dlx1 Top 200 Genes BrainMap 5.957E-13 1.917E-11 1.337E-10 3.568E-10 8 347
19 GSM605773 500 alpha beta T cells, T.8.TI.B16, 4- 8+ TCR+ 45+, B16 Melanoma Tumor, avg-2 Immgen.org, GSE15907 7.828E-13 1.917E-11 1.337E-10 4.689E-10 8 359
20 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Overall Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Overall Top 200 Genes 8.003E-13 1.917E-11 1.337E-10 4.794E-10 7 182
21 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Top 200 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Top 200 BrainMap 8.003E-13 1.917E-11 1.337E-10 4.794E-10 7 182
22 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Overall Top 200 Genes BrainMap 8.003E-13 1.917E-11 1.337E-10 4.794E-10 7 182
23 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Overall Top 200 Genes BrainMap 8.003E-13 1.917E-11 1.337E-10 4.794E-10 7 182
24 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Overall Top 200 Genes BrainMap 8.003E-13 1.917E-11 1.337E-10 4.794E-10 7 182
25 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Top 200 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Top 200 BrainMap 8.003E-13 1.917E-11 1.337E-10 4.794E-10 7 182
26 GSM538352 500 B cells, proB.FrA.BM, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Bone marrow, avg-2 Immgen.org, GSE15907 1.461E-12 3.365E-11 2.347E-10 8.750E-10 8 388
27 GSM538338 500 alpha beta T cells, NKT.44-NK1.1-.Th, aGC CD1d tet CD3e, Thymus, avg-2 Immgen.org, GSE15907 1.792E-12 3.975E-11 2.772E-10 1.073E-9 8 398
28 GSM605898 500 alpha beta T cells, T.8Eff.Sp.OT1.d6.LisOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 1.941E-12 4.153E-11 2.896E-10 1.163E-9 8 402
29 GSM791149 500 alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 2.410E-12 4.979E-11 3.472E-10 1.444E-9 8 413
30 GSM538350 500 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 2.654E-12 5.300E-11 3.696E-10 1.590E-9 8 418
31 GSM476658 500 gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2 Immgen.org, GSE15907 2.865E-12 5.363E-11 3.740E-10 1.716E-9 8 422
32 GSM791124 500 B cells, MLP.BM, CD19- IgM- CD43+ CD24- AA4.1+ CD45R- CD117+ IL7R-, Bone marrow, avg-2 Immgen.org, GSE15907 2.865E-12 5.363E-11 3.740E-10 1.716E-9 8 422
33 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Striatum Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Striatum Top 200 Genes BrainMap 4.768E-11 8.655E-10 6.035E-9 2.856E-8 7 325
34 Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma Heterologous Type/2/3 Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma Heterologous Type/2/3 TCGA-Uterus 5.016E-11 8.838E-10 6.163E-9 3.005E-8 6 154
35 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Hippocampus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Hippocampus Top 200 Genes BrainMap 7.546E-11 1.291E-9 9.006E-9 4.520E-8 7 347
36 GSM476675 500 gamma delta T cells, Tgd.Th, TCRd+ CD3e+, Thymus, avg-3 Immgen.org, GSE15907 7.856E-11 1.307E-9 9.115E-9 4.706E-8 7 349
37 GSM399385 500 alpha beta T cells, T.8SP69+.Th, 4- 8+ TCRhi 69+, Thymus, avg-3 Immgen.org, GSE15907 1.015E-10 1.631E-9 1.137E-8 6.079E-8 7 362
38 GSM605784 500 gamma delta T cells, Tgd.vg1+vd6-.Th.TCRbko, TCRd+ Vg1.1+, Thymus, avg-3 Immgen.org, GSE15907 1.035E-10 1.631E-9 1.137E-8 6.198E-8 7 363
39 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s3 intermediate neurons Subtype intermediate neurons s3 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s3 intermediate neurons Subtype intermediate neurons s3 Top 100 Genes 1.089E-10 1.672E-9 1.166E-8 6.521E-8 6 175
40 GSM538309 500 NK cells, NK.MCMV1.Sp, CD3-,NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 1.117E-10 1.673E-9 1.167E-8 6.692E-8 7 367
41 GSM605781 500 gamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3 Immgen.org, GSE15907 1.251E-10 1.828E-9 1.275E-8 7.496E-8 7 373
42 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/pre-natural killer cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/pre-natural killer cell Tabula Muris Consortium 1.524E-10 2.173E-9 1.515E-8 9.127E-8 6 185
43 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/Slamf1-positive multipotent progenitor cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/Slamf1-positive multipotent progenitor cell Tabula Muris Consortium 1.848E-10 2.574E-9 1.795E-8 1.107E-7 6 191
44 GSM399397 500 alpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3 Immgen.org, GSE15907 2.005E-10 2.703E-9 1.885E-8 1.201E-7 7 399
45 Cap mesenchyme (CM) Cap mesenchyme (CM) 2.030E-10 2.703E-9 1.885E-8 1.216E-7 6 194
46 GSM791139 500 alpha beta T cells, preT.DN2A.Th, Lin-/lo CD25hi CD44+ cKithi, Thymus, avg-2 Immgen.org, GSE15907 2.383E-10 3.103E-9 2.164E-8 1.427E-7 7 409
47 GSM605793 500 gamma delta T cells, Tgd.vg2+24ahi.Th.TCRbko, TCRd+ Vg2+ CD24+, Thymus, avg-3 Immgen.org, GSE15907 2.508E-10 3.196E-9 2.229E-8 1.502E-7 7 412
48 GSM791134 500 alpha beta T cells, preT.DN2-3.Th, Lin-/lo CD25hi CD44Int, Thymus, avg-2 Immgen.org, GSE15907 2.638E-10 3.292E-9 2.296E-8 1.580E-7 7 415
49 GSM791131 500 B cells, MLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-3 Immgen.org, GSE15907 3.115E-10 3.808E-9 2.656E-8 1.866E-7 7 425
50 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Top 200 BrainMap 7.174E-10 8.594E-9 5.993E-8 4.297E-7 7 479
Show 45 more annotations

15: Computational [Display Chart] 10 input genes in category / 111 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M582 MODULE 57 Genes in the cancer module 57. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.488E-17 2.762E-15 1.461E-14 2.762E-15 8 56
2 M17594 GNF2 MCM4 Neighborhood of MCM4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.346E-12 1.857E-10 9.826E-10 3.714E-10 6 53
3 M5444 GNF2 RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.279E-12 2.315E-10 1.225E-9 8.080E-10 6 60
4 M5468 MODULE 54 Cell cycle (expression cluster). MSigDb: C4 - CM: Cancer Modules (v6.0) 8.344E-12 2.315E-10 1.225E-9 9.262E-10 8 262
5 M17279 GNF2 PCNA Neighborhood of PCNA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.587E-11 3.523E-10 1.864E-9 1.762E-9 6 68
6 M11786 GNF2 RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.804E-11 1.444E-9 7.639E-9 8.662E-9 6 88
7 M14325 GNF2 FEN1 Neighborhood of FEN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.111E-9 1.762E-8 9.324E-8 1.234E-7 5 56
8 M11522 GNF2 MCM5 Neighborhood of MCM5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.727E-9 2.396E-8 1.268E-7 1.917E-7 5 61
9 M7419 GNF2 CCNA2 Neighborhood of CCNA2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.017E-9 3.722E-8 1.969E-7 3.349E-7 5 68
10 M12856 GNF2 SMC4L1 Neighborhood of SMC4L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.877E-9 9.853E-8 5.214E-7 9.853E-7 5 84
11 M11613 GNF2 RRM2 Neighborhood of RRM2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.464E-8 4.504E-7 2.383E-6 4.955E-6 4 40
12 M6330 MODULE 158 DNA replication. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.019E-8 5.567E-7 2.946E-6 6.681E-6 4 43
13 M15402 MODULE 125 Genes in the cancer module 125. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.618E-8 5.650E-7 2.990E-6 7.345E-6 4 44
14 M10439 GNF2 CENPF Neighborhood of CENPF MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.696E-7 2.138E-6 1.131E-5 2.993E-5 4 62
15 M13609 MORF PRKDC Neighborhood of PRKDC MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.382E-7 3.983E-6 2.107E-5 5.974E-5 5 190
16 M218 GNF2 PA2G4 Neighborhood of PA2G4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.202E-7 4.997E-6 2.644E-5 7.994E-5 4 79
17 M10242 GNF2 MSH2 Neighborhood of MSH2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.303E-6 1.504E-5 7.957E-5 2.556E-4 3 28
18 M13419 MORF BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.413E-6 2.039E-5 1.079E-4 3.789E-4 5 276
19 M10146 MORF DNMT1 Neighborhood of DNMT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.489E-6 2.039E-5 1.079E-4 3.873E-4 4 117
20 M13406 GNF2 RFC3 Neighborhood of RFC3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.443E-6 4.131E-5 2.186E-4 8.262E-4 3 41
21 M8304 GNF2 BUB1B Neighborhood of BUB1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.281E-5 6.648E-5 3.517E-4 1.422E-3 3 49
22 M16298 GNF2 HAT1 Neighborhood of HAT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.362E-5 6.648E-5 3.517E-4 1.512E-3 3 50
23 M4409 MODULE 17 Genes in the cancer module 17. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.377E-5 6.648E-5 3.517E-4 1.529E-3 5 367
24 M9199 MODULE 3 Genes in the cancer module 3. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.739E-5 8.042E-5 4.255E-4 1.930E-3 5 385
25 M8921 MODULE 53 Cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.224E-5 9.583E-5 5.071E-4 2.468E-3 5 405
26 M949 MODULE 244 Response to DNA damage. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.245E-5 9.583E-5 5.071E-4 2.492E-3 4 187
27 M10414 MORF ESPL1 Neighborhood of ESPL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.487E-5 1.022E-4 5.409E-4 2.760E-3 3 61
28 M4 MORF FEN1 Neighborhood of FEN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.012E-5 1.194E-4 6.317E-4 3.343E-3 3 65
29 M5625 MORF BUB1B Neighborhood of BUB1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.154E-5 1.207E-4 6.387E-4 3.500E-3 3 66
30 M4550 MODULE 252 TFs and nuclear. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.692E-5 2.106E-4 1.114E-3 6.318E-3 4 237
31 M1104 MORF RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.161E-4 4.157E-4 2.200E-3 1.289E-2 3 102
32 M17658 MODULE 198 Genes in the cancer module 198. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.481E-4 5.136E-4 2.718E-3 1.644E-2 4 303
33 M5308 GNF2 SMC1L1 Neighborhood of SMC1L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.095E-4 1.041E-3 5.508E-3 3.435E-2 2 27
34 M16797 MODULE 318 Genes in the cancer module 318. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.331E-4 1.087E-3 5.754E-3 3.697E-2 2 28
35 M13545 MORF RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.635E-4 1.153E-3 6.100E-3 4.035E-2 3 150
36 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.028E-4 1.242E-3 6.572E-3 4.472E-2 4 393
37 M6962 GNF2 SMC2L1 Neighborhood of SMC2L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.640E-4 1.348E-3 7.131E-3
5.151E-2
 2 33
38 M18610 MORF PPP1CC Neighborhood of PPP1CC MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.724E-4 1.348E-3 7.131E-3
5.244E-2
 3 164
39 M12108 MODULE 118 cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.735E-4 1.348E-3 7.131E-3
5.256E-2
 4 410
40 M664 GNF2 ESPL1 Neighborhood of ESPL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.224E-4 1.418E-3 7.504E-3
5.798E-2
 2 35
41 M956 MODULE 8 Genes in the cancer module 8. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.238E-4 1.418E-3 7.504E-3
5.814E-2
 4 421
42 M14741 GCM ANP32B Neighborhood of ANP32B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.528E-4 1.450E-3 7.674E-3
6.136E-2
 2 36
43 M4092 MODULE 197 Genes in the cancer module 197. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.618E-4 1.450E-3 7.674E-3
6.236E-2
 3 174
44 M10065 GNF2 CKS1B Neighborhood of CKS1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.841E-4 1.473E-3 7.796E-3
6.483E-2
 2 37
45 M4598 GNF2 TTK Neighborhood of TTK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.492E-4 1.601E-3 8.473E-3
7.206E-2
 2 39
46 M15619 MODULE 18 Genes in the cancer module 18. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.804E-4 1.642E-3 8.687E-3
7.552E-2
 4 451
47 M5464 MODULE 403 DNA damage response. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.034E-4 2.133E-3 1.129E-2
1.003E-1
 2 46
48 M12521 GNF2 HMMR Neighborhood of HMMR MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.430E-4 2.181E-3 1.154E-2
1.047E-1
 2 47
49 M3537 GNF2 CKS2 Neighborhood of CKS2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.067E-3 2.417E-3 1.279E-2
1.184E-1
 2 50
50 M17151 GNF2 CDC20 Neighborhood of CDC20 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.337E-3 2.968E-3 1.571E-2
1.484E-1
 2 56
Show 45 more annotations

16: MicroRNA [Display Chart] 11 input genes in category / 289 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-373-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.195E-7 2.207E-5 1.378E-4 6.344E-5 4 371
2 hsa-miR-371b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.219E-7 2.207E-5 1.378E-4 6.413E-5 4 372
3 hsa-miR-616-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.291E-7 2.207E-5 1.378E-4 6.622E-5 4 375
4 hsa-miR-4649-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.472E-7 2.662E-5 1.663E-4 1.292E-4 3 102
5 hsa-miR-6729-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.606E-7 2.662E-5 1.663E-4 1.331E-4 3 103
6 hsa-miR-372-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.490E-5 6.256E-4 3.907E-3 4.305E-3 3 328
7 hsa-miR-423-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.702E-5 6.256E-4 3.907E-3 4.919E-3 3 343
8 hsa-miR-371a-5p:Functional MTI Functional MTI miRTarbase 1.732E-5 6.256E-4 3.907E-3 5.005E-3 3 345
9 hsa-miR-4253:mirSVR highEffct hsa-miR-4253:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.566E-5 1.421E-3 8.876E-3 1.320E-2 3 478
10 hsa-miR-501-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.917E-5 1.421E-3 8.876E-3 1.421E-2 2 69
11 hsa-miR-3141:mirSVR highEffct hsa-miR-3141:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.618E-5 1.739E-3 1.086E-2 1.913E-2 2 80
12 hsa-miR-4486:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.057E-4 4.953E-3 3.093E-2
5.943E-2
 2 141
13 hsa-miR-548p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.358E-4 5.241E-3 3.273E-2
6.814E-2
 2 151
14 hsa-miR-3184-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.533E-4 7.294E-3 4.555E-2
1.021E-1
 2 185
15 hsa-miR-6741-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.781E-4 1.114E-2
6.956E-2
1.671E-1
 2 237
16 hsa-miR-4638-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.174E-4 1.115E-2
6.965E-2
1.784E-1
 2 245
17 hsa-miR-93-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.431E-4 1.246E-2
7.784E-2
2.148E-1
 2 269
18 hsa-miR-1260b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.763E-4 1.246E-2
7.784E-2
2.244E-1
 2 275
19 hsa-miR-6791-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.061E-3 1.411E-2
8.810E-2
3.066E-1
 2 322
20 hsa-miR-6829-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.061E-3 1.411E-2
8.810E-2
3.066E-1
 2 322
21 hsa-miR-3672:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.074E-3 1.411E-2
8.810E-2
3.103E-1
 2 324
22 hsa-miR-6864-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.074E-3 1.411E-2
8.810E-2
3.103E-1
 2 324
23 hsa-miR-140-3p.2:TargetScan hsa-miR-140-3p.2 TargetScan 1.272E-3 1.598E-2
9.981E-2
3.676E-1
 2 353
24 hsa-miR-504-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.556E-3 1.646E-2
1.028E-1
4.497E-1
 2 391
25 hsa-miR-3135b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.580E-3 1.646E-2
1.028E-1
4.565E-1
 2 394
26 hsa-miR-222-3p:Functional MTI Functional MTI miRTarbase 1.580E-3 1.646E-2
1.028E-1
4.565E-1
 2 394
27 hsa-miR-3652:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.603E-3 1.646E-2
1.028E-1
4.634E-1
 2 397
28 hsa-miR-4430:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.603E-3 1.646E-2
1.028E-1
4.634E-1
 2 397
29 hsa-miR-148b-3p:Functional MTI Functional MTI miRTarbase 1.651E-3 1.646E-2
1.028E-1
4.773E-1
 2 403
30 hsa-miR-27a*:mirSVR highEffct hsa-miR-27a*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.885E-3 1.781E-2
1.112E-1
5.447E-1
 2 431
31 hsa-miR-939-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.954E-3 1.781E-2
1.112E-1
5.648E-1
 2 439
32 hsa-miR-184:mirSVR lowEffct hsa-miR-184:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 1.972E-3 1.781E-2
1.112E-1
5.698E-1
 2 441
33 hsa-miR-661:Functional MTI Functional MTI miRTarbase 2.133E-3 1.804E-2
1.127E-1
6.164E-1
 2 459
34 hsa-miR-6890-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.207E-3 1.804E-2
1.127E-1
6.377E-1
 2 467
35 hsa-miR-7703:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.272E-3 1.804E-2
1.127E-1
6.566E-1
 2 474
36 hsa-miR-508-5p:Functional MTI Functional MTI miRTarbase 2.300E-3 1.804E-2
1.127E-1
6.648E-1
 2 477
37 hsa-miR-4304:mirSVR lowEffct hsa-miR-4304:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.310E-3 1.804E-2
1.127E-1
6.675E-1
 2 478
38 hsa-miR-662:Functional MTI Functional MTI miRTarbase 3.193E-3 2.366E-2
1.478E-1
9.228E-1
 1 21
39 hsa-miR-147b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.193E-3 2.366E-2
1.478E-1
9.228E-1
 1 21
40 hsa-miR-6853-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.165E-3 3.732E-2
2.331E-1
1.000E0
 1 34
41 hsa-miR-1301-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.468E-3 3.763E-2
2.350E-1
1.000E0
 1 36
42 hsa-miR-6502-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.468E-3 3.763E-2
2.350E-1
1.000E0
 1 36
43 hsa-miR-4766-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.771E-3 3.879E-2
2.423E-1
1.000E0
 1 38
44 hsa-miR-1251-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.226E-3 4.089E-2
2.554E-1
1.000E0
 1 41
45 hsa-miR-6820-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.377E-3 4.096E-2
2.558E-1
1.000E0
 1 42
46 hsa-miR-517-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.134E-3 4.482E-2
2.799E-1
1.000E0
 1 47
47 hsa-miR-5571-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.588E-3 4.557E-2
2.846E-1
1.000E0
 1 50
48 hsa-miR-4259:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.890E-3 4.557E-2
2.846E-1
1.000E0
 1 52
49 hsa-miR-6510-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.041E-3 4.557E-2
2.846E-1
1.000E0
 1 53
50 hsa-miR-99b-5p:Functional MTI Functional MTI miRTarbase 8.041E-3 4.557E-2
2.846E-1
1.000E0
 1 53
Show 45 more annotations

17: Drug [Display Chart] 11 input genes in category / 864 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C014026 hexamethylene bisacetamide CTD 3.954E-19 3.416E-16 2.507E-15 3.416E-16 8 64
2 CID000003657 hydroxyurea Stitch 1.718E-14 7.424E-12 5.449E-11 1.485E-11 9 438
3 ctd:D000069439 Dasatinib CTD 5.165E-10 1.488E-7 1.092E-6 4.463E-7 7 478
4 CID000002210 NSC351140 Stitch 8.636E-10 1.865E-7 1.369E-6 7.461E-7 6 258
5 ctd:D012835 Silver Nitrate CTD 1.589E-9 2.746E-7 2.015E-6 1.373E-6 5 119
6 ctd:D018021 Lithium Chloride CTD 3.710E-9 5.343E-7 3.921E-6 3.206E-6 6 329
7 ctd:C006551 2-amino-2-methyl-1-propanol CTD 4.929E-9 6.084E-7 4.465E-6 4.259E-6 6 345
8 ctd:C059765 amphotericin B, deoxycholate drug combination CTD 1.025E-8 1.107E-6 8.125E-6 8.856E-6 6 390
9 6895 DN 0297417-0002B [362658-29-5]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.909E-8 1.833E-6 1.345E-5 1.650E-5 5 195
10 ctd:D002509 Cephaloridine CTD 3.193E-8 2.758E-6 2.024E-5 2.758E-5 6 472
11 ctd:C024015 cryptolepine CTD 1.464E-7 1.150E-5 8.438E-5 1.265E-4 3 23
12 ctd:D001507 Beclomethasone CTD 2.399E-7 1.727E-5 1.268E-4 2.073E-4 5 324
13 ctd:C058305 phenethyl isothiocyanate CTD 7.324E-7 4.868E-5 3.573E-4 6.328E-4 5 406
14 ctd:C008493 methylselenic acid CTD 7.969E-7 4.918E-5 3.610E-4 6.885E-4 5 413
15 CID000003134 6-DMAP Stitch 1.015E-6 5.820E-5 4.272E-4 8.767E-4 3 43
16 ctd:C496197 trans-10,cis-12-conjugated linoleic acid CTD 1.078E-6 5.820E-5 4.272E-4 9.313E-4 4 176
17 4452 DN geldanamycin; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.463E-6 7.298E-5 5.356E-4 1.264E-3 4 190
18 1773 DN Chrysene-1,4-quinone [100900-16-1]; Down 200; 15.4uM; HL60; HG-U133A Broad Institute CMAP Down 1.557E-6 7.298E-5 5.356E-4 1.345E-3 4 193
19 6902 DN 0297417-0002B [362658-29-5]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.655E-6 7.298E-5 5.356E-4 1.430E-3 4 196
20 2439 DN Menadione [58-27-5]; Down 200; 23.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.689E-6 7.298E-5 5.356E-4 1.460E-3 4 197
21 ctd:C030123 coumarin CTD 2.179E-6 8.963E-5 6.578E-4 1.882E-3 4 210
22 CID000079034 1-2H Stitch 2.527E-6 9.924E-5 7.284E-4 2.183E-3 3 58
23 CID000006623 bisphenol A Stitch 2.766E-6 1.039E-4 7.626E-4 2.390E-3 4 223
24 ctd:D003345 Corticosterone CTD 6.439E-6 2.318E-4 1.701E-3 5.564E-3 4 276
25 CID000028780 benomyl Stitch 2.745E-5 9.486E-4 6.962E-3 2.371E-2 3 128
26 ctd:C494474 perchlorate CTD 3.078E-5 1.023E-3 7.507E-3 2.659E-2 3 133
27 CID000072271 UCN-01 Stitch 4.766E-5 1.525E-3 1.119E-2 4.118E-2 3 154
28 ctd:C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) CTD 5.295E-5 1.621E-3 1.190E-2 4.575E-2 4 472
29 ctd:D001622 Betaine CTD 5.441E-5 1.621E-3 1.190E-2 4.701E-2 3 161
30 ctd:C105832 aurapten CTD 5.786E-5 1.666E-3 1.223E-2 4.999E-2 2 24
31 4430 DN 17-AAG; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Down 8.092E-5 2.255E-3 1.655E-2
6.991E-2
 3 184
32 CID000124245 hydroxymethylreductic acid Stitch 8.500E-5 2.294E-3 1.684E-2
7.344E-2
 2 29
33 6717 DN Promethazine hydrochloride [58-33-3]; Down 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 8.762E-5 2.294E-3 1.684E-2
7.570E-2
 3 189
34 1409 DN Etofylline [519-37-9]; Down 200; 17.8uM; HL60; HG-U133A Broad Institute CMAP Down 9.467E-5 2.359E-3 1.732E-2
8.180E-2
 3 194
35 1053 DN prochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 9.613E-5 2.359E-3 1.732E-2
8.305E-2
 3 195
36 1732 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HG-U133A Broad Institute CMAP Down 9.908E-5 2.359E-3 1.732E-2
8.560E-2
 3 197
37 4085 DN Thioridazine hydrochloride [130-61-0]; Down 200; 9.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.021E-4 2.359E-3 1.732E-2
8.820E-2
 3 199
38 CID000002384 AC1L1DK5 Stitch 1.038E-4 2.359E-3 1.732E-2
8.965E-2
 2 32
39 CID000010944 A-Mate Stitch 1.104E-4 2.446E-3 1.796E-2
9.541E-2
 2 33
40 ctd:D005031 Ethylenethiourea CTD 1.244E-4 2.686E-3 1.972E-2
1.075E-1
 2 35
41 CID000041322 anti-BaPDE Stitch 1.648E-4 3.474E-3 2.549E-2
1.424E-1
 3 234
42 CID000137566 4 A 3 Stitch 2.157E-4 4.335E-3 3.181E-2
1.864E-1
 2 46
43 ctd:C121707 7,3'-dihydroxy-4'-methoxyisoflavone CTD 2.157E-4 4.335E-3 3.181E-2
1.864E-1
 2 46
44 ctd:D008769 Methylnitronitrosoguanidine CTD 2.431E-4 4.774E-3 3.504E-2
2.101E-1
 3 267
45 CID000412123 AC1L92T5 Stitch 3.201E-4 6.147E-3 4.511E-2
2.766E-1
 2 56
46 CID000448249 O-Ir Stitch 3.317E-4 6.230E-3 4.572E-2
2.866E-1
 2 57
47 ctd:C014476 diethyl maleate CTD 4.250E-4 7.812E-3
5.733E-2
3.672E-1
 3 323
48 CID000323970 AC1L89QG Stitch 4.721E-4 8.497E-3
6.236E-2
4.079E-1
 2 68
49 ctd:D001285 Atropine CTD 8.807E-4 1.553E-2
1.140E-1
7.609E-1
 2 93
50 ctd:D010882 Piperonyl Butoxide CTD 9.835E-4 1.700E-2
1.247E-1
8.498E-1
 3 431
Show 45 more annotations

18: Disease [Display Chart] 11 input genes in category / 188 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0025286 Meningioma DisGeNET Curated 1.034E-7 1.945E-5 1.131E-4 1.945E-5 6 409
2 C1868684 EAR, PATELLA, SHORT STATURE SYNDROME DisGeNET Curated 1.255E-6 1.180E-4 6.864E-4 2.360E-4 3 33
3 C4280443 Absent bone maturation in sternum DisGeNET Curated 2.512E-6 1.180E-4 6.866E-4 4.722E-4 2 4
4 C1857074 Absent sternal ossification DisGeNET Curated 2.512E-6 1.180E-4 6.866E-4 4.722E-4 2 4
5 C1855650 Birth length less than 3rd percentile DisGeNET Curated 6.274E-6 2.359E-4 1.372E-3 1.180E-3 2 6
6 C0151779 Cutaneous Melanoma DisGeNET Curated 1.676E-5 5.251E-4 3.054E-3 3.151E-3 4 250
7 C1868577 Patella aplasia-hypoplasia DisGeNET Curated 3.254E-5 8.740E-4 5.083E-3 6.118E-3 2 13
8 C0007129 Merkel cell carcinoma DisGeNET Curated 4.444E-5 1.044E-3 6.074E-3 8.354E-3 3 107
9 C1833144 Slender, gracile long tubular bones DisGeNET Curated 8.735E-5 1.825E-3 1.061E-2 1.642E-2 2 21
10 C0266013 Congenital hypoplasia of breast DisGeNET Curated 1.349E-4 2.484E-3 1.445E-2 2.537E-2 2 26
11 C0426817 Short ribs DisGeNET Curated 1.803E-4 2.484E-3 1.445E-2 3.391E-2 2 30
12 C0544755 Genu varum DisGeNET Curated 1.803E-4 2.484E-3 1.445E-2 3.391E-2 2 30
13 C1512433 High Grade Cervical Squamous Intraepithelial Neoplasia DisGeNET BeFree 1.927E-4 2.484E-3 1.445E-2 3.623E-2 2 31
14 C0021296 Infant, Small for Gestational Age DisGeNET Curated 1.982E-4 2.484E-3 1.445E-2 3.726E-2 3 177
15 C1386048 Intrauterine retardation DisGeNET Curated 1.982E-4 2.484E-3 1.445E-2 3.726E-2 3 177
16 C0015934 Fetal Growth Retardation DisGeNET Curated 2.294E-4 2.696E-3 1.568E-2 4.313E-2 3 186
17 C0156394 Hypertrophy of clitoris DisGeNET Curated 3.726E-4 4.120E-3 2.396E-2
7.004E-2
 2 43
18 C0013336 Dwarfism DisGeNET Curated 4.390E-4 4.586E-3 2.667E-2
8.254E-2
 3 232
19 C0152423 Congenital small ears DisGeNET Curated 6.100E-4 4.999E-3 2.908E-2
1.147E-1
 2 55
20 cv:C3151113 Meier-Gorlin syndrome 3 Clinical Variations 6.788E-4 4.999E-3 2.908E-2
1.276E-1
 1 1
21 C4021589 Absent glenoid fossa DisGeNET Curated 6.788E-4 4.999E-3 2.908E-2
1.276E-1
 1 1
22 C3151113 MEIER-GORLIN SYNDROME 3 DisGeNET Curated 6.788E-4 4.999E-3 2.908E-2
1.276E-1
 1 1
23 cv:C0268181 Nonpersistence of intestinal lactase Clinical Variations 6.788E-4 4.999E-3 2.908E-2
1.276E-1
 1 1
24 cv:C1864947 Natural killer cell deficiency, familial isolated Clinical Variations 6.788E-4 4.999E-3 2.908E-2
1.276E-1
 1 1
25 cv:CN030358 Meier-Gorlin syndrome 1 Clinical Variations 6.788E-4 4.999E-3 2.908E-2
1.276E-1
 1 1
26 C2053437 Full lower lip DisGeNET Curated 8.254E-4 4.999E-3 2.908E-2
1.552E-1
 2 64
27 C1839739 Prominent lower lip DisGeNET Curated 8.254E-4 4.999E-3 2.908E-2
1.552E-1
 2 64
28 C0240310 Hypoplasia of the maxilla DisGeNET Curated 8.775E-4 4.999E-3 2.908E-2
1.650E-1
 2 66
29 C4280643 Decreased projection of maxilla DisGeNET Curated 8.775E-4 4.999E-3 2.908E-2
1.650E-1
 2 66
30 C4082243 Maxillary retrognathia DisGeNET Curated 8.775E-4 4.999E-3 2.908E-2
1.650E-1
 2 66
31 C4280641 Hypotrophic maxilla DisGeNET Curated 8.775E-4 4.999E-3 2.908E-2
1.650E-1
 2 66
32 C4280640 Retrusion of upper jaw bones DisGeNET Curated 8.775E-4 4.999E-3 2.908E-2
1.650E-1
 2 66
33 C4280642 Deficiency of upper jaw bones DisGeNET Curated 8.775E-4 4.999E-3 2.908E-2
1.650E-1
 2 66
34 C0026034 Microstomia DisGeNET Curated 1.223E-3 6.763E-3 3.933E-2
2.299E-1
 2 78
35 C1855177 Flat glenoid fossa DisGeNET Curated 1.357E-3 7.088E-3 4.122E-2
2.552E-1
 1 2
36 C1864947 Natural Killer Cell Deficiency, Familial Isolated DisGeNET Curated 1.357E-3 7.088E-3 4.122E-2
2.552E-1
 1 2
37 C0424688 Small head DisGeNET Curated 1.767E-3 8.976E-3
5.221E-2
3.321E-1
 3 375
38 C4025857 Incomplete partition of the cochlea type II DisGeNET Curated 2.035E-3 9.332E-3
5.428E-2
3.826E-1
 1 3
39 C3697776 Proliferative verrucous oral leukoplakia DisGeNET BeFree 2.035E-3 9.332E-3
5.428E-2
3.826E-1
 1 3
40 C1859455 Small anterior fontanelle DisGeNET Curated 2.035E-3 9.332E-3
5.428E-2
3.826E-1
 1 3
41 C1857078 Mondini malformation DisGeNET Curated 2.035E-3 9.332E-3
5.428E-2
3.826E-1
 1 3
42 C0004135 Ataxia Telangiectasia DisGeNET Curated 2.233E-3 9.995E-3
5.814E-2
4.198E-1
 3 407
43 C1336084 Squamous Lung Dysplasia DisGeNET BeFree 2.713E-3 1.186E-2
6.898E-2
5.100E-1
 1 4
44 C0022951 Lactose Intolerance DisGeNET Curated 3.390E-3 1.385E-2
8.058E-2
6.373E-1
 1 5
45 C1969653 MUNGAN SYNDROME DisGeNET Curated 3.390E-3 1.385E-2
8.058E-2
6.373E-1
 1 5
46 C0426805 Hooked clavicle DisGeNET Curated 3.390E-3 1.385E-2
8.058E-2
6.373E-1
 1 5
47 C1266025 Traditional Serrated Adenoma DisGeNET BeFree 3.503E-3 1.401E-2
8.150E-2
6.586E-1
 2 133
48 C0541764 Delayed bone age DisGeNET Curated 3.659E-3 1.433E-2
8.336E-2
6.880E-1
 2 136
49 C0268540 HHH syndrome DisGeNET Curated 4.067E-3 1.529E-2
8.893E-2
7.645E-1
 1 6
50 C0423807 Overcurvature of nail DisGeNET Curated 4.067E-3 1.529E-2
8.893E-2
7.645E-1
 1 6
Show 45 more annotations