|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
19840946
|
PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis.
|
Pubmed
|
2.154E-12
|
1.271E-10
|
8.195E-10
|
7.625E-10
|
3
|
3
|
|
2
|
19037259
|
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.
|
Pubmed
|
2.154E-12
|
1.271E-10
|
8.195E-10
|
7.625E-10
|
3
|
3
|
|
3
|
17556371
|
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex.
|
Pubmed
|
2.154E-12
|
1.271E-10
|
8.195E-10
|
7.625E-10
|
3
|
3
|
|
4
|
18950639
|
ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality.
|
Pubmed
|
2.154E-12
|
1.271E-10
|
8.195E-10
|
7.625E-10
|
3
|
3
|
|
5
|
23047693
|
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.
|
Pubmed
|
2.154E-12
|
1.271E-10
|
8.195E-10
|
7.625E-10
|
3
|
3
|
|
6
|
22028665
|
Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.
|
Pubmed
|
2.154E-12
|
1.271E-10
|
8.195E-10
|
7.625E-10
|
3
|
3
|
|
7
|
22696681
|
Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.
|
Pubmed
|
4.307E-11
|
2.178E-9
|
1.405E-8
|
1.525E-8
|
3
|
6
|
|
8
|
15542851
|
A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
9
|
19793721
|
Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
10
|
17827176
|
Dok-1 is a positive regulator of IL-4 signalling and IgE response.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
11
|
26405034
|
The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
12
|
27664281
|
Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
13
|
21732353
|
Dok-1 and Dok-2 deficiency induces osteopenia via activation of osteoclasts.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
14
|
17329234
|
Dok-1 and Dok-2 are negative regulators of T cell receptor signaling.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
15
|
25252871
|
Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML).
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
16
|
15699069
|
Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
17
|
16177091
|
Phosphotyrosine binding-mediated oligomerization of downstream of tyrosine kinase (Dok)-1 and Dok-2 is involved in CD2-induced Dok phosphorylation.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
18
|
22842785
|
Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)Pâ?? and PI(5)P.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
19
|
19299694
|
Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
20
|
21655088
|
Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
21
|
15611294
|
Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
22
|
14647425
|
Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
23
|
24963146
|
Dok1 and Dok2 proteins regulate natural killer cell development and function.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
24
|
15611295
|
Role of Dok-1 and Dok-2 in leukemia suppression.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
25
|
28490594
|
Dok-1 and Dok-2 Are Required To Maintain Herpes Simplex Virus 1-Specific CD8(+) T Cells in a Murine Model of Ocular Infection.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
26
|
27183638
|
Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
27
|
20630877
|
ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
28
|
17475247
|
ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
29
|
23659921
|
Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
30
|
16823827
|
All-trans retinoic acid induces p62DOK1 and p56DOK2 expression which enhances induced differentiation and G0 arrest of HL-60 leukemia cells.
|
Pubmed
|
2.057E-8
|
2.427E-7
|
1.565E-6
|
7.281E-6
|
2
|
2
|
|
31
|
27265473
|
Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells.
|
Pubmed
|
6.170E-8
|
5.200E-7
|
3.353E-6
|
2.184E-5
|
2
|
3
|
|
32
|
26125944
|
The Amyloid Precursor Protein Controls PIKfyve Function.
|
Pubmed
|
6.170E-8
|
5.200E-7
|
3.353E-6
|
2.184E-5
|
2
|
3
|
|
33
|
22370159
|
The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling.
|
Pubmed
|
6.170E-8
|
5.200E-7
|
3.353E-6
|
2.184E-5
|
2
|
3
|
|
34
|
22736313
|
Dok-1 overexpression promotes development of γδ natural killer T cells.
|
Pubmed
|
6.170E-8
|
5.200E-7
|
3.353E-6
|
2.184E-5
|
2
|
3
|
|
35
|
26934981
|
A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity.
|
Pubmed
|
6.170E-8
|
5.200E-7
|
3.353E-6
|
2.184E-5
|
2
|
3
|
|
36
|
20548287
|
Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.
|
Pubmed
|
6.170E-8
|
5.200E-7
|
3.353E-6
|
2.184E-5
|
2
|
3
|
|
37
|
26216398
|
APP controls the formation of PI(3,5)P(2) vesicles through its binding of the PIKfyve complex.
|
Pubmed
|
6.170E-8
|
5.200E-7
|
3.353E-6
|
2.184E-5
|
2
|
3
|
|
38
|
21078907
|
Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling.
|
Pubmed
|
6.170E-8
|
5.200E-7
|
3.353E-6
|
2.184E-5
|
2
|
3
|
|
39
|
23205702
|
Dok adaptors play anti-inflammatory roles in pulmonary homeostasis.
|
Pubmed
|
6.170E-8
|
5.200E-7
|
3.353E-6
|
2.184E-5
|
2
|
3
|
|
40
|
20139980
|
Identification of DOK genes as lung tumor suppressors.
|
Pubmed
|
6.170E-8
|
5.200E-7
|
3.353E-6
|
2.184E-5
|
2
|
3
|
|
41
|
29548825
|
Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia.
|
Pubmed
|
6.170E-8
|
5.200E-7
|
3.353E-6
|
2.184E-5
|
2
|
3
|
|
42
|
24600036
|
PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3.
|
Pubmed
|
6.170E-8
|
5.200E-7
|
3.353E-6
|
2.184E-5
|
2
|
3
|
|
43
|
27450811
|
Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22.
|
Pubmed
|
1.234E-7
|
9.495E-7
|
6.122E-6
|
4.368E-5
|
2
|
4
|
|
44
|
17092301
|
Differential regulation of adapter proteins Dok2 and Dok1 in platelets, leading to an association of Dok2 with integrin alphaIIbbeta3.
|
Pubmed
|
1.234E-7
|
9.495E-7
|
6.122E-6
|
4.368E-5
|
2
|
4
|
|
45
|
18429927
|
Endosomal phosphoinositides and human diseases.
|
Pubmed
|
1.234E-7
|
9.495E-7
|
6.122E-6
|
4.368E-5
|
2
|
4
|
|
46
|
9478921
|
Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins.
|
Pubmed
|
1.234E-7
|
9.495E-7
|
6.122E-6
|
4.368E-5
|
2
|
4
|
|
47
|
10822173
|
The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells.
|
Pubmed
|
2.056E-7
|
1.516E-6
|
9.778E-6
|
7.279E-5
|
2
|
5
|
|
48
|
10799545
|
Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling.
|
Pubmed
|
2.056E-7
|
1.516E-6
|
9.778E-6
|
7.279E-5
|
2
|
5
|
|
49
|
26885983
|
The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.
|
Pubmed
|
2.194E-7
|
1.585E-6
|
1.022E-5
|
7.766E-5
|
3
|
86
|
|
50
|
18774718
|
PtdIns5P regulation through evolution: roles in membrane trafficking?
|
Pubmed
|
3.084E-7
|
2.184E-6
|
1.408E-5
|
1.092E-4
|
2
|
6
|