Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc249_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 60 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004991 parathyroid hormone receptor activity 1.206E-7 7.237E-6 3.387E-5 7.237E-6 2 2
2 GO:0051428 peptide hormone receptor binding 1.636E-5 4.908E-4 2.297E-3 9.816E-4 2 17
3 GO:0031856 parathyroid hormone receptor binding 3.751E-4 5.627E-3 2.633E-2 2.251E-2 1 1
4 GO:0031857 type 1 parathyroid hormone receptor binding 3.751E-4 5.627E-3 2.633E-2 2.251E-2 1 1
5 GO:0031852 mu-type opioid receptor binding 1.500E-3 1.349E-2
6.315E-2
8.998E-2
 1 4
6 GO:0051430 corticotropin-releasing hormone receptor 1 binding 1.500E-3 1.349E-2
6.315E-2
8.998E-2
 1 4
7 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity 1.874E-3 1.349E-2
6.315E-2
1.125E-1
 1 5
8 GO:0051427 hormone receptor binding 1.945E-3 1.349E-2
6.315E-2
1.167E-1
 2 183
9 GO:0051429 corticotropin-releasing hormone receptor binding 2.249E-3 1.349E-2
6.315E-2
1.349E-1
 1 6
10 GO:0031698 beta-2 adrenergic receptor binding 2.249E-3 1.349E-2
6.315E-2
1.349E-1
 1 6
11 GO:0005315 inorganic phosphate transmembrane transporter activity 2.623E-3 1.431E-2
6.696E-2
1.574E-1
 1 7
12 GO:0031628 opioid receptor binding 3.372E-3 1.586E-2
7.422E-2
2.023E-1
 1 9
13 GO:0005436 sodium:phosphate symporter activity 3.746E-3 1.586E-2
7.422E-2
2.247E-1
 1 10
14 GO:0015321 sodium-dependent phosphate transmembrane transporter activity 3.746E-3 1.586E-2
7.422E-2
2.247E-1
 1 10
15 GO:0031748 D1 dopamine receptor binding 4.120E-3 1.586E-2
7.422E-2
2.472E-1
 1 11
16 GO:0001664 G protein-coupled receptor binding 4.358E-3 1.586E-2
7.422E-2
2.615E-1
 2 276
17 GO:0031681 G-protein beta-subunit binding 4.493E-3 1.586E-2
7.422E-2
2.696E-1
 1 12
18 GO:0005159 insulin-like growth factor receptor binding 5.614E-3 1.871E-2
8.758E-2
3.368E-1
 1 15
19 GO:0015114 phosphate ion transmembrane transporter activity 6.734E-3 2.126E-2
9.951E-2
4.040E-1
 1 18
20 GO:0000993 RNA polymerase II complex binding 7.107E-3 2.132E-2
9.977E-2
4.264E-1
 1 19
21 GO:0031690 adrenergic receptor binding 7.479E-3 2.137E-2
1.000E-1
4.488E-1
 1 20
22 GO:0050780 dopamine receptor binding 8.225E-3 2.242E-2
1.049E-1
4.935E-1
 1 22
23 GO:0043175 RNA polymerase core enzyme binding 8.597E-3 2.242E-2
1.049E-1
5.158E-1
 1 23
24 GO:0031683 G-protein beta/gamma-subunit complex binding 8.970E-3 2.242E-2
1.049E-1
5.382E-1
 1 24
25 GO:0035255 ionotropic glutamate receptor binding 9.714E-3 2.321E-2
1.086E-1
5.828E-1
 1 26
26 GO:0001099 basal RNA polymerase II transcription machinery binding 1.046E-2 2.321E-2
1.086E-1
6.275E-1
 1 28
27 GO:0001098 basal transcription machinery binding 1.046E-2 2.321E-2
1.086E-1
6.275E-1
 1 28
28 GO:0043014 alpha-tubulin binding 1.083E-2 2.321E-2
1.086E-1
6.498E-1
 1 29
29 GO:0071855 neuropeptide receptor binding 1.157E-2 2.394E-2
1.121E-1
6.944E-1
 1 31
30 GO:0001965 G-protein alpha-subunit binding 1.232E-2 2.463E-2
1.153E-1
7.389E-1
 1 33
31 GO:0070063 RNA polymerase binding 1.380E-2 2.657E-2
1.243E-1
8.279E-1
 1 37
32 GO:0005484 SNAP receptor activity 1.417E-2 2.657E-2
1.243E-1
8.502E-1
 1 38
33 GO:0017046 peptide hormone binding 1.676E-2 3.023E-2
1.415E-1
1.000E0
 1 45
34 GO:0035254 glutamate receptor binding 1.713E-2 3.023E-2
1.415E-1
1.000E0
 1 46
35 GO:0015296 anion:cation symporter activity 1.787E-2 3.063E-2
1.434E-1
1.000E0
 1 48
36 GO:0043621 protein self-association 2.082E-2 3.470E-2
1.624E-1
1.000E0
 1 56
37 GO:0042562 hormone binding 3.073E-2 4.983E-2
2.332E-1
1.000E0
 1 83
Show 32 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 379 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 2.740E-6 1.038E-3 6.766E-3 1.038E-3 3 81
2 GO:0071107 response to parathyroid hormone 9.428E-6 1.787E-3 1.164E-2 3.573E-3 2 13
3 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 2.007E-5 2.535E-3 1.652E-2 7.606E-3 3 157
4 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 3.226E-5 3.056E-3 1.992E-2 1.223E-2 3 184
5 GO:0001894 tissue homeostasis 6.946E-5 5.265E-3 3.431E-2 2.632E-2 3 238
6 GO:0045453 bone resorption 2.647E-4 1.213E-2
7.903E-2
1.003E-1
 2 67
7 GO:0048871 multicellular organismal homeostasis 2.733E-4 1.213E-2
7.903E-2
1.036E-1
 3 378
8 GO:0010676 positive regulation of cellular carbohydrate metabolic process 3.142E-4 1.213E-2
7.903E-2
1.191E-1
 2 73
9 GO:0060249 anatomical structure homeostasis 3.276E-4 1.213E-2
7.903E-2
1.242E-1
 3 402
10 GO:0001503 ossification 3.324E-4 1.213E-2
7.903E-2
1.260E-1
 3 404
11 GO:0040032 post-embryonic body morphogenesis 3.759E-4 1.213E-2
7.903E-2
1.425E-1
 1 1
12 GO:0055074 calcium ion homeostasis 3.858E-4 1.213E-2
7.903E-2
1.462E-1
 3 425
13 GO:0045913 positive regulation of carbohydrate metabolic process 4.160E-4 1.213E-2
7.903E-2
1.577E-1
 2 84
14 GO:0072507 divalent inorganic cation homeostasis 4.805E-4 1.285E-2
8.375E-2
1.821E-1
 3 458
15 GO:0046849 bone remodeling 5.207E-4 1.285E-2
8.375E-2
1.973E-1
 2 94
16 GO:0045778 positive regulation of ossification 5.774E-4 1.285E-2
8.375E-2
2.188E-1
 2 99
17 GO:0006112 energy reserve metabolic process 6.248E-4 1.285E-2
8.375E-2
2.368E-1
 2 103
18 GO:0043255 regulation of carbohydrate biosynthetic process 6.248E-4 1.285E-2
8.375E-2
2.368E-1
 2 103
19 GO:0030282 bone mineralization 6.993E-4 1.285E-2
8.375E-2
2.650E-1
 2 109
20 GO:1900373 positive regulation of purine nucleotide biosynthetic process 7.121E-4 1.285E-2
8.375E-2
2.699E-1
 2 110
21 GO:0030810 positive regulation of nucleotide biosynthetic process 7.121E-4 1.285E-2
8.375E-2
2.699E-1
 2 110
22 GO:0006171 cAMP biosynthetic process 9.475E-4 1.632E-2
1.064E-1
3.591E-1
 2 127
23 GO:2000828 regulation of parathyroid hormone secretion 1.127E-3 1.660E-2
1.081E-1
4.272E-1
 1 3
24 GO:0090290 positive regulation of osteoclast proliferation 1.127E-3 1.660E-2
1.081E-1
4.272E-1
 1 3
25 GO:0045981 positive regulation of nucleotide metabolic process 1.166E-3 1.660E-2
1.081E-1
4.419E-1
 2 141
26 GO:1900544 positive regulation of purine nucleotide metabolic process 1.166E-3 1.660E-2
1.081E-1
4.419E-1
 2 141
27 GO:0031214 biomineral tissue development 1.182E-3 1.660E-2
1.081E-1
4.481E-1
 2 142
28 GO:1900371 regulation of purine nucleotide biosynthetic process 1.318E-3 1.745E-2
1.137E-1
4.995E-1
 2 150
29 GO:0030808 regulation of nucleotide biosynthetic process 1.335E-3 1.745E-2
1.137E-1
5.061E-1
 2 151
30 GO:0052652 cyclic purine nucleotide metabolic process 1.424E-3 1.764E-2
1.149E-1
5.398E-1
 2 156
31 GO:0009190 cyclic nucleotide biosynthetic process 1.442E-3 1.764E-2
1.149E-1
5.467E-1
 2 157
32 GO:0046058 cAMP metabolic process 1.516E-3 1.796E-2
1.170E-1
5.746E-1
 2 161
33 GO:0035898 parathyroid hormone secretion 1.878E-3 1.906E-2
1.242E-1
7.118E-1
 1 5
34 GO:0008628 hormone-mediated apoptotic signaling pathway 1.878E-3 1.906E-2
1.242E-1
7.118E-1
 1 5
35 GO:0071866 negative regulation of apoptotic process in bone marrow 1.878E-3 1.906E-2
1.242E-1
7.118E-1
 1 5
36 GO:0090289 regulation of osteoclast proliferation 1.878E-3 1.906E-2
1.242E-1
7.118E-1
 1 5
37 GO:0071865 regulation of apoptotic process in bone marrow 1.878E-3 1.906E-2
1.242E-1
7.118E-1
 1 5
38 GO:0048771 tissue remodeling 1.911E-3 1.906E-2
1.242E-1
7.241E-1
 2 181
39 GO:0010675 regulation of cellular carbohydrate metabolic process 2.037E-3 1.980E-2
1.290E-1
7.722E-1
 2 187
40 GO:0071839 apoptotic process in bone marrow 2.253E-3 2.037E-2
1.328E-1
8.541E-1
 1 6
41 GO:0006109 regulation of carbohydrate metabolic process 2.258E-3 2.037E-2
1.328E-1
8.557E-1
 2 197
42 GO:0051216 cartilage development 2.258E-3 2.037E-2
1.328E-1
8.557E-1
 2 197
43 GO:0045637 regulation of myeloid cell differentiation 2.442E-3 2.076E-2
1.353E-1
9.255E-1
 2 205
44 GO:0030278 regulation of ossification 2.465E-3 2.076E-2
1.353E-1
9.344E-1
 2 206
45 GO:0009187 cyclic nucleotide metabolic process 2.465E-3 2.076E-2
1.353E-1
9.344E-1
 2 206
46 GO:0071864 positive regulation of cell proliferation in bone marrow 2.629E-3 2.108E-2
1.374E-1
9.962E-1
 1 7
47 GO:0060789 hair follicle placode formation 2.629E-3 2.108E-2
1.374E-1
9.962E-1
 1 7
48 GO:0006814 sodium ion transport 2.756E-3 2.108E-2
1.374E-1
1.000E0
 2 218
49 GO:0016051 carbohydrate biosynthetic process 2.806E-3 2.108E-2
1.374E-1
1.000E0
 2 220
50 GO:0001649 osteoblast differentiation 2.881E-3 2.108E-2
1.374E-1
1.000E0
 2 223
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 41 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031526 brush border membrane 2.378E-4 7.761E-3 3.340E-2 9.751E-3 2 65
2 GO:0032588 trans-Golgi network membrane 3.786E-4 7.761E-3 3.340E-2 1.552E-2 2 82
3 GO:0005903 brush border 9.335E-4 1.276E-2
5.489E-2
 3.827E-2 2 129
4 GO:0098862 cluster of actin-based cell projections 1.708E-3 1.750E-2
7.531E-2
7.001E-2
 2 175
5 GO:0016593 Cdc73/Paf1 complex 2.568E-3 1.767E-2
7.602E-2
1.053E-1
 1 7
6 GO:0005802 trans-Golgi network 2.586E-3 1.767E-2
7.602E-2
1.060E-1
 2 216
7 GO:0098791 Golgi subcompartment 5.786E-3 2.589E-2
1.114E-1
2.372E-1
 2 326
8 GO:0031253 cell projection membrane 5.995E-3 2.589E-2
1.114E-1
2.458E-1
 2 332
9 GO:0016324 apical plasma membrane 6.101E-3 2.589E-2
1.114E-1
2.501E-1
 2 335
10 GO:0031984 organelle subcompartment 6.315E-3 2.589E-2
1.114E-1
2.589E-1
 2 341
11 GO:0045177 apical part of cell 9.803E-3 3.654E-2
1.572E-1
4.019E-1
 2 428
12 GO:0005834 heterotrimeric G-protein complex 1.387E-2 4.740E-2
2.040E-1
5.688E-1
 1 38
Show 7 more annotations

4: Human Phenotype [Display Chart] 6 input genes in category / 880 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0100529 Abnormality of phosphate homeostasis 5.772E-11 5.079E-8 3.737E-7 5.079E-8 6 95
2 HP:0004363 Abnormality of calcium homeostasis 4.993E-9 1.705E-6 1.255E-5 4.394E-6 6 197
3 HP:0010927 Abnormality of divalent inorganic cation homeostasis 5.814E-9 1.705E-6 1.255E-5 5.116E-6 6 202
4 HP:0100530 Abnormality of calcium-phosphate metabolism 2.289E-8 5.037E-6 3.706E-5 2.015E-5 4 31
5 HP:0011767 Abnormality of the parathyroid physiology 3.417E-8 6.015E-6 4.425E-5 3.007E-5 5 108
6 HP:0000828 Abnormality of the parathyroid gland 4.699E-8 6.892E-6 5.071E-5 4.135E-5 5 115
7 HP:0010929 Abnormality of cation homeostasis 1.315E-7 1.502E-5 1.105E-4 1.158E-4 6 338
8 HP:0040077 Abnormal concentration of calcium in blood 1.365E-7 1.502E-5 1.105E-4 1.201E-4 5 142
9 HP:0003111 Abnormality of ion homeostasis 2.128E-7 2.080E-5 1.531E-4 1.872E-4 6 366
10 HP:0012599 Abnormal urine phosphate concentration 3.280E-7 2.886E-5 2.124E-4 2.886E-4 4 59
11 HP:0003165 Elevated circulating parathyroid hormone level 7.777E-7 6.222E-5 4.578E-4 6.844E-4 3 17
12 HP:0002148 Hypophosphatemia 1.075E-6 7.886E-5 5.802E-4 9.463E-4 4 79
13 HP:0005700 Increased bone density with cystic changes 4.061E-6 2.102E-4 1.547E-3 3.573E-3 2 3
14 HP:0003456 Low urinary cyclic AMP response to PTH administration 4.061E-6 2.102E-4 1.547E-3 3.573E-3 2 3
15 HP:0003472 Hypocalcemic tetany 4.061E-6 2.102E-4 1.547E-3 3.573E-3 2 3
16 HP:0008227 Pituitary resistance to thyroid hormone 4.061E-6 2.102E-4 1.547E-3 3.573E-3 2 3
17 HP:0003909 Cortical subperiosteal resorption of humeral metaphyses 4.061E-6 2.102E-4 1.547E-3 3.573E-3 2 3
18 HP:0002905 Hyperphosphatemia 6.788E-6 3.319E-4 2.442E-3 5.974E-3 3 34
19 HP:0000684 Delayed eruption of teeth 9.289E-6 4.302E-4 3.165E-3 8.174E-3 4 135
20 HP:0012591 Abnormal urinary electrolyte concentration 1.270E-5 5.589E-4 4.112E-3 1.118E-2 4 146
21 HP:0006292 Abnormality of dental eruption 1.740E-5 7.293E-4 5.366E-3 1.532E-2 4 158
22 HP:0003155 Elevated alkaline phosphatase 2.068E-5 8.273E-4 6.087E-3 1.820E-2 4 165
23 HP:0002653 Bone pain 2.222E-5 8.342E-4 6.137E-3 1.955E-2 4 168
24 HP:0004379 Abnormality of alkaline phosphatase activity 2.275E-5 8.342E-4 6.137E-3 2.002E-2 4 169
25 HP:0003907 Abnormality of the humeral metaphyses 2.836E-5 9.983E-4 7.345E-3 2.496E-2 2 7
26 HP:0000829 Hypoparathyroidism 3.283E-5 1.087E-3 8.001E-3 2.889E-2 3 57
27 HP:0002901 Hypocalcemia 3.460E-5 1.087E-3 8.001E-3 3.045E-2 3 58
28 HP:0031547 Abnormal QT interval 3.460E-5 1.087E-3 8.001E-3 3.045E-2 3 58
29 HP:0002199 Hypocalcemic seizures 4.856E-5 1.474E-3 1.084E-2 4.274E-2 2 9
30 HP:0012379 Abnormal enzyme/coenzyme activity 5.086E-5 1.492E-3 1.098E-2 4.476E-2 4 207
31 HP:0012049 Laryngeal dystonia 6.067E-5 1.722E-3 1.267E-2
5.339E-2
 2 10
32 HP:0002659 Increased susceptibility to fractures 6.471E-5 1.779E-3 1.309E-2
5.694E-2
 4 220
33 HP:0003034 Diaphyseal sclerosis 7.411E-5 1.910E-3 1.406E-2
6.522E-2
 2 11
34 HP:0000940 Abnormal diaphysis morphology 7.712E-5 1.910E-3 1.406E-2
6.787E-2
 4 230
35 HP:0002150 Hypercalciuria 7.815E-5 1.910E-3 1.406E-2
6.877E-2
 3 76
36 HP:0003115 Abnormal EKG 7.815E-5 1.910E-3 1.406E-2
6.877E-2
 3 76
37 HP:0500014 Abnormal test result 9.116E-5 2.057E-3 1.513E-2
8.022E-2
 3 80
38 HP:0500015 Abnormal cardiac test 9.116E-5 2.057E-3 1.513E-2
8.022E-2
 3 80
39 HP:0003114 Abnormal cardiological findings 9.116E-5 2.057E-3 1.513E-2
8.022E-2
 3 80
40 HP:0000944 Abnormality of the metaphysis 9.578E-5 2.107E-3 1.550E-2
8.429E-2
 4 243
41 HP:0000852 Pseudohypoparathyroidism 1.050E-4 2.110E-3 1.553E-2
9.238E-2
 2 13
42 HP:0003739 Myoclonic spasms 1.050E-4 2.110E-3 1.553E-2
9.238E-2
 2 13
43 HP:0009809 Abnormality of upper limb metaphysis 1.050E-4 2.110E-3 1.553E-2
9.238E-2
 2 13
44 HP:0011280 Abnormality of urine calcium concentration 1.055E-4 2.110E-3 1.553E-2
9.285E-2
 3 84
45 HP:0011865 Abnormal urine cation concentration 1.132E-4 2.214E-3 1.629E-2
9.963E-2
 3 86
46 HP:0004724 Calcium nephrolithiasis 1.224E-4 2.292E-3 1.686E-2
1.077E-1
 2 14
47 HP:0000117 Renal phosphate wasting 1.224E-4 2.292E-3 1.686E-2
1.077E-1
 2 14
48 HP:0003072 Hypercalcemia 1.431E-4 2.623E-3 1.930E-2
1.259E-1
 3 93
49 HP:0002663 Delayed epiphyseal ossification 1.612E-4 2.896E-3 2.131E-2
1.419E-1
 2 16
50 HP:0010766 Ectopic calcification 1.649E-4 2.902E-3 2.135E-2
1.451E-1
 4 279
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 6 input genes in category / 462 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002903 abnormal circulating parathyroid hormone level 9.817E-10 4.535E-7 3.045E-6 4.535E-7 4 31
2 MP:0002905 decreased circulating parathyroid hormone level 2.374E-8 5.483E-6 3.681E-5 1.097E-5 3 12
3 MP:0001562 abnormal circulating calcium level 4.702E-7 7.242E-5 4.862E-4 2.172E-4 4 140
4 MP:0004231 abnormal calcium ion homeostasis 2.005E-6 1.890E-4 1.269E-3 9.264E-4 4 201
5 MP:0003055 abnormal long bone epiphyseal plate morphology 2.045E-6 1.890E-4 1.269E-3 9.450E-4 4 202
6 MP:0006395 abnormal epiphyseal plate morphology 2.877E-6 2.077E-4 1.394E-3 1.329E-3 4 220
7 MP:0000164 abnormal cartilage development 3.147E-6 2.077E-4 1.394E-3 1.454E-3 4 225
8 MP:0000194 increased circulating calcium level 4.880E-6 2.818E-4 1.892E-3 2.254E-3 3 66
9 MP:0003662 abnormal long bone epiphyseal plate proliferative zone 8.734E-6 4.484E-4 3.010E-3 4.035E-3 3 80
10 MP:0001565 abnormal circulating phosphate level 2.157E-5 9.966E-4 6.691E-3 9.966E-3 3 108
11 MP:0000163 abnormal cartilage morphology 3.411E-5 1.432E-3 9.617E-3 1.576E-2 4 410
12 MP:0000547 short limbs 4.119E-5 1.586E-3 1.065E-2 1.903E-2 3 134
13 MP:0000165 abnormal long bone hypertrophic chondrocyte zone 5.545E-5 1.971E-3 1.323E-2 2.562E-2 3 148
14 MP:0006357 abnormal circulating mineral level 6.507E-5 2.147E-3 1.442E-2 3.006E-2 4 483
15 MP:0011228 abnormal vitamin D level 7.041E-5 2.169E-3 1.456E-2 3.253E-2 2 23
16 MP:0002904 increased circulating parathyroid hormone level 7.679E-5 2.217E-3 1.489E-2 3.548E-2 2 24
17 MP:0002896 abnormal bone mineralization 1.442E-4 3.920E-3 2.632E-2
6.664E-2
 3 204
18 MP:0005401 abnormal fat-soluble vitamin level 2.618E-4 6.721E-3 4.512E-2
1.210E-1
 2 44
19 MP:0003408 increased width of hypertrophic chondrocyte zone 3.386E-4 8.232E-3
5.527E-2
1.564E-1
 2 50
20 MP:0000198 decreased circulating phosphate level 3.805E-4 8.790E-3
5.902E-2
1.758E-1
 2 53
21 MP:0005400 abnormal vitamin level 5.043E-4 1.010E-2
6.782E-2
2.330E-1
 2 61
22 MP:0030768 increased urine dopamine level 5.794E-4 1.010E-2
6.782E-2
2.677E-1
 1 1
23 MP:0030767 decreased urine catecholamine level 5.794E-4 1.010E-2
6.782E-2
2.677E-1
 1 1
24 MP:0030773 decreased urine noradrenaline level 5.794E-4 1.010E-2
6.782E-2
2.677E-1
 1 1
25 MP:0003497 insensitivity to parathyroid hormone 5.794E-4 1.010E-2
6.782E-2
2.677E-1
 1 1
26 MP:0030772 increased urine noradrenaline level 5.794E-4 1.010E-2
6.782E-2
2.677E-1
 1 1
27 MP:0004019 abnormal vitamin homeostasis 5.904E-4 1.010E-2
6.782E-2
2.727E-1
 2 66
28 MP:0005006 abnormal osteoblast physiology 6.640E-4 1.096E-2
7.356E-2
3.068E-1
 2 70
29 MP:0004686 decreased length of long bones 8.025E-4 1.278E-2
8.583E-2
3.708E-1
 3 365
30 MP:0000440 domed cranium 1.144E-3 1.673E-2
1.123E-1
5.287E-1
 2 92
31 MP:0003495 increased parathyroid adenoma incidence 1.159E-3 1.673E-2
1.123E-1
5.353E-1
 1 2
32 MP:0013846 retropharyngeal edema 1.159E-3 1.673E-2
1.123E-1
5.353E-1
 1 2
33 MP:0008844 decreased subcutaneous adipose tissue amount 1.405E-3 1.966E-2
1.320E-1
6.489E-1
 2 102
34 MP:0008271 abnormal bone ossification 1.449E-3 1.970E-2
1.322E-1
6.696E-1
 3 447
35 MP:0013863 abnormal paraumbilical vein morphology 1.737E-3 2.007E-2
1.347E-1
8.027E-1
 1 3
36 MP:0012118 absent trophectoderm cell proliferation 1.737E-3 2.007E-2
1.347E-1
8.027E-1
 1 3
37 MP:0030094 foramen magnum stenosis 1.737E-3 2.007E-2
1.347E-1
8.027E-1
 1 3
38 MP:0013963 jugular vein stenosis 1.737E-3 2.007E-2
1.347E-1
8.027E-1
 1 3
39 MP:0013864 enlarged paraumbilical vein 1.737E-3 2.007E-2
1.347E-1
8.027E-1
 1 3
40 MP:0013872 abnormal jugular vein morphology 1.737E-3 2.007E-2
1.347E-1
8.027E-1
 1 3
41 MP:0003641 small lung 1.970E-3 2.220E-2
1.490E-1
9.101E-1
 2 121
42 MP:0030766 increased urine catecholamine level 2.316E-3 2.488E-2
1.671E-1
1.000E0
 1 4
43 MP:0030479 increased osteocyte apoptosis 2.316E-3 2.488E-2
1.671E-1
1.000E0
 1 4
44 MP:0011156 abnormal hypodermis fat layer morphology 2.590E-3 2.674E-2
1.796E-1
1.000E0
 2 139
45 MP:0010110 abnormal renal phosphate reabsorbtion 2.894E-3 2.674E-2
1.796E-1
1.000E0
 1 5
46 MP:0011563 increased urine prostaglandin level 2.894E-3 2.674E-2
1.796E-1
1.000E0
 1 5
47 MP:0012336 decreased vitamin D level 2.894E-3 2.674E-2
1.796E-1
1.000E0
 1 5
48 MP:0030478 abnormal osteocyte apoptosis 2.894E-3 2.674E-2
1.796E-1
1.000E0
 1 5
49 MP:0030477 abnormal osteocyte physiology 2.894E-3 2.674E-2
1.796E-1
1.000E0
 1 5
50 MP:0010321 increased parathyroid gland tumor incidence 2.894E-3 2.674E-2
1.796E-1
1.000E0
 1 5
Show 45 more annotations

6: Domain [Display Chart] 7 input genes in category / 45 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00008 HormR SMART 3.575E-5 6.953E-4 3.056E-3 1.609E-3 2 25
2 PF02793 HRM Pfam 4.502E-5 6.953E-4 3.056E-3 2.026E-3 2 28
3 IPR017983 GPCR 2 secretin-like CS InterPro 6.675E-5 6.953E-4 3.056E-3 3.004E-3 2 34
4 IPR001879 GPCR 2 extracellular dom InterPro 9.271E-5 6.953E-4 3.056E-3 4.172E-3 2 40
5 PS00649 G PROTEIN RECEP F2 1 PROSITE 9.271E-5 6.953E-4 3.056E-3 4.172E-3 2 40
6 PS50227 G PROTEIN RECEP F2 3 PROSITE 9.271E-5 6.953E-4 3.056E-3 4.172E-3 2 40
7 PS00650 G PROTEIN RECEP F2 2 PROSITE 1.453E-4 7.642E-4 3.359E-3 6.540E-3 2 50
8 PF00002 7tm 2 Pfam 1.453E-4 7.642E-4 3.359E-3 6.540E-3 2 50
9 IPR000832 GPCR 2 secretin-like InterPro 2.096E-4 7.642E-4 3.359E-3 9.433E-3 2 60
10 IPR017981 GPCR 2-like InterPro 2.096E-4 7.642E-4 3.359E-3 9.433E-3 2 60
11 PS50261 G PROTEIN RECEP F2 4 PROSITE 2.167E-4 7.642E-4 3.359E-3 9.751E-3 2 61
12 IPR031336 CDC73 C InterPro 3.736E-4 7.642E-4 3.359E-3 1.681E-2 1 1
13 PF06390 NESP55 Pfam 3.736E-4 7.642E-4 3.359E-3 1.681E-2 1 1
14 PF05179 CDC73 C Pfam 3.736E-4 7.642E-4 3.359E-3 1.681E-2 1 1
15 IPR003625 PTH InterPro 3.736E-4 7.642E-4 3.359E-3 1.681E-2 1 1
16 PF16050 CDC73 N Pfam 3.736E-4 7.642E-4 3.359E-3 1.681E-2 1 1
17 IPR002170 GPCR 2 parathyroid rcpt InterPro 3.736E-4 7.642E-4 3.359E-3 1.681E-2 1 1
18 IPR029850 Na/Pi transpt 2C InterPro 3.736E-4 7.642E-4 3.359E-3 1.681E-2 1 1
19 IPR028673 STX16 InterPro 3.736E-4 7.642E-4 3.359E-3 1.681E-2 1 1
20 IPR009434 NESP55 InterPro 3.736E-4 7.642E-4 3.359E-3 1.681E-2 1 1
21 IPR032041 Cdc73 N InterPro 3.736E-4 7.642E-4 3.359E-3 1.681E-2 1 1
22 IPR007852 Cdc73/Parafibromin InterPro 3.736E-4 7.642E-4 3.359E-3 1.681E-2 1 1
23 IPR003626 PTH-rel InterPro 7.471E-4 1.201E-3 5.277E-3 3.362E-2 1 2
24 PS00335 PARATHYROID PROSITE 7.471E-4 1.201E-3 5.277E-3 3.362E-2 1 2
25 IPR001415 PTH/PTH-rel InterPro 7.471E-4 1.201E-3 5.277E-3 3.362E-2 1 2
26 PF01279 Parathyroid Pfam 7.471E-4 1.201E-3 5.277E-3 3.362E-2 1 2
27 IPR000367 Gprotein alpha S InterPro 7.471E-4 1.201E-3 5.277E-3 3.362E-2 1 2
28 SM00087 PTH SMART 7.471E-4 1.201E-3 5.277E-3 3.362E-2 1 2
29 IPR003841 Na/Pi transpt InterPro 1.121E-3 1.681E-3 7.387E-3
5.042E-2
 1 3
30 PF02690 Na Pi cotrans Pfam 1.121E-3 1.681E-3 7.387E-3
5.042E-2
 1 3
31 PF00804 Syntaxin Pfam 4.103E-3 5.957E-3 2.618E-2
1.847E-1
 1 11
32 IPR006011 Syntaxin N InterPro 4.476E-3 6.294E-3 2.766E-2
2.014E-1
 1 12
33 SM00275 G alpha SMART 5.964E-3 7.062E-3 3.104E-2
2.684E-1
 1 16
34 IPR006012 Syntaxin/epimorphin CS InterPro 5.964E-3 7.062E-3 3.104E-2
2.684E-1
 1 16
35 PS00914 SYNTAXIN PROSITE 5.964E-3 7.062E-3 3.104E-2
2.684E-1
 1 16
36 PF00503 G-alpha Pfam 5.964E-3 7.062E-3 3.104E-2
2.684E-1
 1 16
37 IPR011025 GproteinA insert InterPro 5.964E-3 7.062E-3 3.104E-2
2.684E-1
 1 16
38 1.10.400.10 - Gene3D 5.964E-3 7.062E-3 3.104E-2
2.684E-1
 1 16
39 IPR001019 Gprotein alpha su InterPro 6.335E-3 7.310E-3 3.213E-2
2.851E-1
 1 17
40 PF05739 SNARE Pfam 7.821E-3 8.799E-3 3.867E-2
3.520E-1
 1 21
41 SM00397 t SNARE SMART 8.192E-3 8.992E-3 3.952E-2
3.687E-1
 1 22
42 IPR002885 Pentatricopeptide repeat InterPro 8.563E-3 9.175E-3 4.032E-2
3.853E-1
 1 23
43 PS50192 T SNARE PROSITE 9.676E-3 1.013E-2 4.450E-2
4.354E-1
 1 26
44 IPR000727 T SNARE dom InterPro 1.079E-2 1.103E-2 4.849E-2
4.854E-1
 1 29
45 IPR010989 t-SNARE InterPro 1.596E-2 1.596E-2
7.014E-2
7.181E-1
 1 43
Show 40 more annotations

7: Pathway [Display Chart] 7 input genes in category / 96 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269570 Class B/2 (Secretin family receptors) BioSystems: REACTOME 1.004E-7 9.637E-6 4.960E-5 9.637E-6 4 93
2 1269575 G alpha (s) signalling events BioSystems: REACTOME 6.181E-7 2.967E-5 1.527E-4 5.934E-5 4 146
3 1269544 GPCR ligand binding BioSystems: REACTOME 5.644E-5 1.806E-3 9.296E-3 5.419E-3 4 455
4 213307 Endocrine and other factor-regulated calcium reabsorption BioSystems: KEGG 2.894E-4 6.946E-3 3.575E-2 2.778E-2 2 47
5 1269915 Type II Na+/Pi cotransporters BioSystems: REACTOME 1.686E-3 3.237E-2
1.666E-1
1.618E-1
 1 3
6 1269633 Signaling by Hedgehog BioSystems: REACTOME 2.577E-3 3.370E-2
1.735E-1
2.474E-1
 2 141
7 PW:0000676 glucagon signaling pathway Pathway Ontology 2.809E-3 3.370E-2
1.735E-1
2.696E-1
 1 5
8 1269914 Sodium-coupled phosphate cotransporters BioSystems: REACTOME 2.809E-3 3.370E-2
1.735E-1
2.696E-1
 1 5
9 M7772 fl-arrestins in GPCR Desensitization MSigDB C2 BIOCARTA (v6.0) 5.610E-3 4.998E-2
2.572E-1
5.386E-1
 1 10
10 M12399 Cystic Fibrosis Transmembrane Conductance Regulator And Beta 2 Adrenergic Receptor Pathway MSigDB C2 BIOCARTA (v6.0) 6.729E-3 4.998E-2
2.572E-1
6.460E-1
 1 12
11 M5576 Phospholipase C-epsilon pathway MSigDB C2 BIOCARTA (v6.0) 6.729E-3 4.998E-2
2.572E-1
6.460E-1
 1 12
12 M668 Role of fl-arrestins in the activation and targeting of MAP kinases MSigDB C2 BIOCARTA (v6.0) 6.729E-3 4.998E-2
2.572E-1
6.460E-1
 1 12
13 M19829 Attenuation of GPCR Signaling MSigDB C2 BIOCARTA (v6.0) 7.288E-3 4.998E-2
2.572E-1
6.997E-1
 1 13
14 PW:0000713 vasopressin signaling pathway via receptor type 2 Pathway Ontology 7.288E-3 4.998E-2
2.572E-1
6.997E-1
 1 13
Show 9 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 1648 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18280230 Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes. Pubmed 1.508E-11 2.485E-8 1.984E-7 2.485E-8 3 4
2 12036966 Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. Pubmed 3.605E-10 2.971E-7 2.372E-6 5.941E-7 4 70
3 18240029 Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. Pubmed 2.523E-8 2.063E-6 1.647E-5 4.157E-5 4 200
4 22338074 Parathyroid hormone induces bone formation in phosphorylation-deficient PTHR1 knockin mice. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
5 25218037 A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
6 26307011 The G protein α subunit variant XLαs promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
7 15459318 Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
8 21777186 The parathyroid hormone receptorsome and the potential for therapeutic intervention. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
9 21756942 PTH-receptors regulate norepinephrine release in human heart and kidney. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
10 20501677 Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
11 22896038 Parathyroid hormone stimulates juxtaglomerular cell cAMP accumulation without stimulating renin release. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
12 26303600 PTH receptor-1 signalling-mechanistic insights and therapeutic prospects. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
13 20061437 Pseudohypoparathyroidism and GNAS epigenetic defects: clinical evaluation of albright hereditary osteodystrophy and molecular analysis in 40 patients. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
14 9482662 Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
15 17526947 Mutation of phenylalanine-34 of parathyroid hormone disrupts NHERF1 regulation of PTH type I receptor signaling. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
16 17317779 Lack of Gnas epigenetic changes and pseudohypoparathyroidism type Ib in mice with targeted disruption of syntaxin-16. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
17 7797535 Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
18 12403624 Residue 19 of the parathyroid hormone (PTH) modulates ligand interaction with the juxtamembrane region of the PTH-1 receptor. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
19 18539702 Ligand-receptor interactions at the parathyroid hormone receptors: subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
20 23095209 Neuromuscular symptoms in a patient with familial pseudohypoparathyroidism type Ib diagnosed by methylation-specific multiplex ligation-dependent probe amplification. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
21 23160461 Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
22 25891861 A Homozygous [Cys25]PTH(1-84) Mutation That Impairs PTH/PTHrP Receptor Activation Defines a Novel Form of Hypoparathyroidism. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
23 26669699 PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer. Pubmed 2.879E-8 2.063E-6 1.647E-5 4.745E-5 2 2
24 20139972 TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling. Pubmed 8.637E-8 4.313E-6 3.444E-5 1.423E-4 2 3
25 29072892 Disorders of GNAS Inactivation Pubmed 8.637E-8 4.313E-6 3.444E-5 1.423E-4 2 3
26 8185578 The rat, mouse and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous. Pubmed 8.637E-8 4.313E-6 3.444E-5 1.423E-4 2 3
27 11897779 Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells. Pubmed 8.637E-8 4.313E-6 3.444E-5 1.423E-4 2 3
28 28363951 Heterotrimeric G proteins in the control of parathyroid hormone actions. Pubmed 8.637E-8 4.313E-6 3.444E-5 1.423E-4 2 3
29 24877630 Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes. Pubmed 8.637E-8 4.313E-6 3.444E-5 1.423E-4 2 3
30 19674967 Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides. Pubmed 8.637E-8 4.313E-6 3.444E-5 1.423E-4 2 3
31 20808842 Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss. Pubmed 8.637E-8 4.313E-6 3.444E-5 1.423E-4 2 3
32 12947048 Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor. Pubmed 8.637E-8 4.313E-6 3.444E-5 1.423E-4 2 3
33 9108031 Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking. Pubmed 8.637E-8 4.313E-6 3.444E-5 1.423E-4 2 3
34 24781502 G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes. Pubmed 1.727E-7 8.372E-6 6.685E-5 2.847E-4 2 4
35 1354597 Localization of mouse parathyroid hormone-like peptide gene (Pthlh) to distal chromosome 6 using interspecific backcross mice and in situ hybridization. Pubmed 2.879E-7 1.318E-5 1.052E-4 4.744E-4 2 5
36 26052897 Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis. Pubmed 2.879E-7 1.318E-5 1.052E-4 4.744E-4 2 5
37 15670850 Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors. Pubmed 1.295E-6 5.767E-5 4.605E-4 2.134E-3 2 10
38 9927325 Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene. Pubmed 1.582E-6 6.519E-5 5.206E-4 2.608E-3 2 11
39 11606467 PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP. Pubmed 1.582E-6 6.519E-5 5.206E-4 2.608E-3 2 11
40 18285546 A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group. Pubmed 1.582E-6 6.519E-5 5.206E-4 2.608E-3 2 11
41 26859889 G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis. Pubmed 3.451E-6 1.387E-4 1.108E-3 5.687E-3 2 16
42 20654748 High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density. Pubmed 7.271E-6 2.853E-4 2.278E-3 1.198E-2 2 23
43 19351817 Genetic mutations associated with cigarette smoking in pancreatic cancer. Pubmed 5.593E-5 3.657E-4 2.920E-3
9.218E-2
 2 63
44 1594625 Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome. Pubmed 1.833E-4 3.657E-4 2.920E-3
3.020E-1
 1 1
45 16099856 A mouse model of albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene. Pubmed 1.833E-4 3.657E-4 2.920E-3
3.020E-1
 1 1
46 25659103 Transcription driven somatic DNA methylation within the imprinted Gnas cluster. Pubmed 1.833E-4 3.657E-4 2.920E-3
3.020E-1
 1 1
47 22954004 GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct. Pubmed 1.833E-4 3.657E-4 2.920E-3
3.020E-1
 1 1
48 21169072 [Different expression of the Asn264LysfsX35 mutation of the GNAS gene in a family with pseudohypoparathyroidism.]. Pubmed 1.833E-4 3.657E-4 2.920E-3
3.020E-1
 1 1
49 728431 Complete amino acid sequence of human parathyroid hormone. Pubmed 1.833E-4 3.657E-4 2.920E-3
3.020E-1
 1 1
50 15016722 Ligand-selective dissociation of activation and internalization of the parathyroid hormone (PTH) receptor: conditional efficacy of PTH peptide fragments. Pubmed 1.833E-4 3.657E-4 2.920E-3
3.020E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 419 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PTH PTH interactions 1.324E-9 5.548E-7 3.671E-6 5.548E-7 3 7
2 int:PTH2R PTH2R interactions 2.009E-6 4.209E-4 2.784E-3 8.417E-4 2 6
3 int:NUCB2 NUCB2 interactions 5.041E-5 7.041E-3 4.659E-2 2.112E-2 2 28
4 int:GNA12 GNA12 interactions 9.862E-5 1.033E-2
6.835E-2
 4.132E-2 2 39
5 int:PTH1R PTH1R interactions 1.829E-4 1.533E-2
1.014E-1
7.664E-2
 2 53
6 int:PAICS PAICS interactions 6.384E-4 4.458E-2
2.949E-1
2.675E-1
 2 99
7 int:SLC34A3 SLC34A3 interactions 7.907E-4 4.729E-2
3.129E-1
3.313E-1
 1 2
8 int:CHEK2 CHEK2 interactions 9.988E-4 4.729E-2
3.129E-1
4.185E-1
 2 124
9 int:GNB1 GNB1 interactions 1.064E-3 4.729E-2
3.129E-1
4.457E-1
 2 128
10 int:PTH2 PTH2 interactions 1.186E-3 4.729E-2
3.129E-1
4.969E-1
 1 3
11 int:ADCY2 ADCY2 interactions 1.581E-3 4.729E-2
3.129E-1
6.624E-1
 1 4
12 int:CCDC88B CCDC88B interactions 1.976E-3 4.729E-2
3.129E-1
8.278E-1
 1 5
13 int:ADRB3 ADRB3 interactions 1.976E-3 4.729E-2
3.129E-1
8.278E-1
 1 5
14 int:HSF2BP HSF2BP interactions 1.976E-3 4.729E-2
3.129E-1
8.278E-1
 1 5
15 int:MYO3B MYO3B interactions 2.370E-3 4.729E-2
3.129E-1
9.932E-1
 1 6
16 int:SLC16A2 SLC16A2 interactions 2.765E-3 4.729E-2
3.129E-1
1.000E0
 1 7
17 int:LHB LHB interactions 2.765E-3 4.729E-2
3.129E-1
1.000E0
 1 7
18 int:BCL9L BCL9L interactions 2.765E-3 4.729E-2
3.129E-1
1.000E0
 1 7
19 int:GCGR GCGR interactions 2.765E-3 4.729E-2
3.129E-1
1.000E0
 1 7
20 int:NNMT NNMT interactions 3.160E-3 4.729E-2
3.129E-1
1.000E0
 1 8
21 int:ADCY5 ADCY5 interactions 3.554E-3 4.729E-2
3.129E-1
1.000E0
 1 9
22 int:PTHLH PTHLH interactions 3.554E-3 4.729E-2
3.129E-1
1.000E0
 1 9
23 int:PTGDR PTGDR interactions 3.554E-3 4.729E-2
3.129E-1
1.000E0
 1 9
24 int:ZDHHC3 ZDHHC3 interactions 3.948E-3 4.729E-2
3.129E-1
1.000E0
 1 10
25 int:GNAL GNAL interactions 3.948E-3 4.729E-2
3.129E-1
1.000E0
 1 10
26 int:CRHR1 CRHR1 interactions 3.948E-3 4.729E-2
3.129E-1
1.000E0
 1 10
27 int:SNX13 SNX13 interactions 3.948E-3 4.729E-2
3.129E-1
1.000E0
 1 10
28 int:VAMP5 VAMP5 interactions 3.948E-3 4.729E-2
3.129E-1
1.000E0
 1 10
29 int:ALG6 ALG6 interactions 4.342E-3 4.729E-2
3.129E-1
1.000E0
 1 11
30 int:PANX1 PANX1 interactions 4.736E-3 4.729E-2
3.129E-1
1.000E0
 1 12
31 int:GNGT1 GNGT1 interactions 5.130E-3 4.729E-2
3.129E-1
1.000E0
 1 13
32 int:RAB40AL RAB40AL interactions 5.130E-3 4.729E-2
3.129E-1
1.000E0
 1 13
33 int:LHCGR LHCGR interactions 5.130E-3 4.729E-2
3.129E-1
1.000E0
 1 13
34 int:SLC44A1 SLC44A1 interactions 5.130E-3 4.729E-2
3.129E-1
1.000E0
 1 13
35 int:EML2 EML2 interactions 5.130E-3 4.729E-2
3.129E-1
1.000E0
 1 13
36 int:ADORA1 ADORA1 interactions 5.130E-3 4.729E-2
3.129E-1
1.000E0
 1 13
37 int:RAB40A RAB40A interactions 5.524E-3 4.729E-2
3.129E-1
1.000E0
 1 14
38 int:VTI1A VTI1A interactions 5.524E-3 4.729E-2
3.129E-1
1.000E0
 1 14
39 int:AVPR2 AVPR2 interactions 5.917E-3 4.729E-2
3.129E-1
1.000E0
 1 15
40 int:PIGM PIGM interactions 5.917E-3 4.729E-2
3.129E-1
1.000E0
 1 15
41 int:ALCAM ALCAM interactions 6.311E-3 4.729E-2
3.129E-1
1.000E0
 1 16
42 int:ERMAP ERMAP interactions 6.311E-3 4.729E-2
3.129E-1
1.000E0
 1 16
43 int:DNAJC17 DNAJC17 interactions 6.311E-3 4.729E-2
3.129E-1
1.000E0
 1 16
44 int:SLC5A3 SLC5A3 interactions 6.311E-3 4.729E-2
3.129E-1
1.000E0
 1 16
45 int:PCP2 PCP2 interactions 6.704E-3 4.729E-2
3.129E-1
1.000E0
 1 17
46 int:SIDT2 SIDT2 interactions 6.704E-3 4.729E-2
3.129E-1
1.000E0
 1 17
47 int:GNG10 GNG10 interactions 6.704E-3 4.729E-2
3.129E-1
1.000E0
 1 17
48 int:ZDHHC7 ZDHHC7 interactions 6.704E-3 4.729E-2
3.129E-1
1.000E0
 1 17
49 int:FLNA FLNA interactions 6.758E-3 4.729E-2
3.129E-1
1.000E0
 2 328
50 int:SLC12A7 SLC12A7 interactions 7.097E-3 4.729E-2
3.129E-1
1.000E0
 1 18
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3p22-p21.1 3p22-p21.1 2.020E-4 1.414E-3 3.665E-3 1.414E-3 1 1
2 11p15.3-p15.1 11p15.3-p15.1 4.039E-4 1.414E-3 3.665E-3 2.827E-3 1 2
3 20q13.3 20q13.3 4.032E-3 6.816E-3 1.767E-2 2.823E-2 1 20
4 20q13.32 20q13.32 4.234E-3 6.816E-3 1.767E-2 2.964E-2 1 21
5 1q25 1q25 5.441E-3 6.816E-3 1.767E-2 3.808E-2 1 27
6 2q33 2q33 5.843E-3 6.816E-3 1.767E-2 4.090E-2 1 29
7 9q34 9q34 1.086E-2 1.086E-2 2.815E-2
7.599E-2
 1 54
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 93 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 7 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 270 Parathyroid hormone receptors genenames.org 1.269E-7 7.613E-7 1.865E-6 7.613E-7 2 2
2 1029 Paf1/RNA polymerase II complex genenames.org 2.307E-3 6.149E-3 1.506E-2 1.384E-2 1 6
3 925 Granins genenames.org 3.074E-3 6.149E-3 1.506E-2 1.845E-2 1 8
4 818 Syntaxins genenames.org 6.141E-3 9.211E-3 2.257E-2 3.684E-2 1 16

13: Coexpression [Display Chart] 7 input genes in category / 525 annotations before applied cutoff / 23137 genes in category

No results to display

14: Coexpression Atlas [Display Chart] 7 input genes in category / 407 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 5 input genes in category / 76 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 7 input genes in category / 297 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1252-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.661E-5 1.684E-2
1.056E-1
 2.869E-2 2 156
2 hsa-miR-6771-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.134E-4 1.684E-2
1.056E-1
 3.367E-2 2 169
3 hsa-miR-155:PITA hsa-miR-155:PITA TOP PITA 3.655E-4 3.159E-2
1.982E-1
1.086E-1
 2 304
4 hsa-miR-324-3p:Functional MTI Functional MTI miRTarbase 4.513E-4 3.159E-2
1.982E-1
1.340E-1
 2 338
5 hsa-miR-155-5p:TargetScan hsa-miR-155-5p TargetScan 5.905E-4 3.159E-2
1.982E-1
1.754E-1
 2 387
6 hsa-miR-331-3p:Functional MTI Functional MTI miRTarbase 6.494E-4 3.159E-2
1.982E-1
1.929E-1
 2 406
7 hsa-miR-579:PITA hsa-miR-579:PITA TOP PITA 7.446E-4 3.159E-2
1.982E-1
2.212E-1
 2 435
8 hsa-miR-1292:PITA hsa-miR-1292:PITA TOP PITA 1.743E-3 4.110E-2
2.578E-1
5.177E-1
 1 18
9 hsa-miR-6786-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.227E-3 4.110E-2
2.578E-1
6.613E-1
 1 23
10 hsa-miR-3150a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.613E-3 4.110E-2
2.578E-1
7.762E-1
 1 27
11 hsa-miR-3150b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.613E-3 4.110E-2
2.578E-1
7.762E-1
 1 27
12 hsa-miR-4540:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.807E-3 4.110E-2
2.578E-1
8.336E-1
 1 29
13 hsa-miR-219b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.676E-3 4.110E-2
2.578E-1
1.000E0
 1 38
14 hsa-miR-425-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 4.110E-2
2.578E-1
1.000E0
 1 48
15 hsa-miR-4274:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.739E-3 4.110E-2
2.578E-1
1.000E0
 1 49
16 hsa-miR-519e-3p:Functional MTI Functional MTI miRTarbase 5.028E-3 4.110E-2
2.578E-1
1.000E0
 1 52
17 hsa-miR-515-3p:Functional MTI Functional MTI miRTarbase 5.125E-3 4.110E-2
2.578E-1
1.000E0
 1 53
18 hsa-miR-6755-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.125E-3 4.110E-2
2.578E-1
1.000E0
 1 53
19 hsa-miR-33b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 4.110E-2
2.578E-1
1.000E0
 1 54
20 hsa-miR-6838-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 4.110E-2
2.578E-1
1.000E0
 1 54
21 hsa-miR-6797-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.607E-3 4.110E-2
2.578E-1
1.000E0
 1 58
22 hsa-miR-6076:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.703E-3 4.110E-2
2.578E-1
1.000E0
 1 59
23 hsa-miR-4642:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 4.110E-2
2.578E-1
1.000E0
 1 60
24 hsa-miR-6807-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 4.110E-2
2.578E-1
1.000E0
 1 60
25 hsa-miR-299-5p:Functional MTI Functional MTI miRTarbase 6.089E-3 4.110E-2
2.578E-1
1.000E0
 1 63
26 hsa-miR-888-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.185E-3 4.110E-2
2.578E-1
1.000E0
 1 64
27 hsa-miR-659-3p:Functional MTI Functional MTI miRTarbase 6.571E-3 4.110E-2
2.578E-1
1.000E0
 1 68
28 hsa-miR-4782-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.571E-3 4.110E-2
2.578E-1
1.000E0
 1 68
29 hsa-miR-5706:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.571E-3 4.110E-2
2.578E-1
1.000E0
 1 68
30 hsa-miR-432-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.667E-3 4.110E-2
2.578E-1
1.000E0
 1 69
31 hsa-miR-4280:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.763E-3 4.110E-2
2.578E-1
1.000E0
 1 70
32 hsa-miR-124-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.860E-3 4.110E-2
2.578E-1
1.000E0
 1 71
33 hsa-miR-634:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.860E-3 4.110E-2
2.578E-1
1.000E0
 1 71
34 hsa-miR-3129-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.630E-3 4.110E-2
2.578E-1
1.000E0
 1 79
35 hsa-miR-217:Functional MTI Functional MTI miRTarbase 7.726E-3 4.110E-2
2.578E-1
1.000E0
 1 80
36 hsa-miR-199b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.919E-3 4.110E-2
2.578E-1
1.000E0
 1 82
37 hsa-miR-7153-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.015E-3 4.110E-2
2.578E-1
1.000E0
 1 83
38 hsa-miR-376b-3p:Non-Functional MTI Non-Functional MTI miRTarbase 8.111E-3 4.110E-2
2.578E-1
1.000E0
 1 84
39 hsa-miR-4733-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.111E-3 4.110E-2
2.578E-1
1.000E0
 1 84
40 hsa-miR-516b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.111E-3 4.110E-2
2.578E-1
1.000E0
 1 84
41 GGCCAGT,MIR-193A:MSigDB GGCCAGT,MIR-193A:MSigDB MSigDB 8.304E-3 4.110E-2
2.578E-1
1.000E0
 1 86
42 GGCCAGT,MIR-193B:MSigDB GGCCAGT,MIR-193B:MSigDB MSigDB 8.304E-3 4.110E-2
2.578E-1
1.000E0
 1 86
43 hsa-miR-1299:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.592E-3 4.110E-2
2.578E-1
1.000E0
 1 89
44 hsa-miR-550a-3-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.785E-3 4.110E-2
2.578E-1
1.000E0
 1 91
45 hsa-miR-1271-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.785E-3 4.110E-2
2.578E-1
1.000E0
 1 91
46 hsa-miR-4519:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.881E-3 4.110E-2
2.578E-1
1.000E0
 1 92
47 hsa-miR-432-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.073E-3 4.110E-2
2.578E-1
1.000E0
 1 94
48 hsa-miR-550a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.169E-3 4.110E-2
2.578E-1
1.000E0
 1 95
49 hsa-miR-8084:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.169E-3 4.110E-2
2.578E-1
1.000E0
 1 95
50 hsa-miR-6073:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.169E-3 4.110E-2
2.578E-1
1.000E0
 1 95
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 1958 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000127325 bp 16 Stitch 1.762E-10 3.450E-7 2.814E-6 3.450E-7 3 5
2 CID000003249 vitamin D2 Stitch 2.756E-9 2.698E-6 2.201E-5 5.396E-6 5 244
3 CID000001593 25(OH) vitamin D3 Stitch 6.159E-8 4.020E-5 3.279E-4 1.206E-4 4 150
4 CID000077996 AC1L2U9H Stitch 1.253E-7 6.133E-5 5.003E-4 2.453E-4 3 36
5 CID005462309 CTK2H7103 Stitch 2.333E-7 9.137E-5 7.454E-4 4.569E-4 4 209
6 CID000122153 N-hydroxysuccinimidyl-4-azidobenzoate Stitch 3.647E-7 9.991E-5 8.150E-4 7.141E-4 3 51
7 CID000006536 triparanol Stitch 4.343E-7 9.991E-5 8.150E-4 8.503E-4 3 54
8 CID000439811 phosphonopyruvate Stitch 4.592E-7 9.991E-5 8.150E-4 8.992E-4 3 55
9 CID006452228 Magnum Stitch 4.592E-7 9.991E-5 8.150E-4 8.992E-4 3 55
10 CID006426615 NO-cAMP Stitch 9.155E-7 1.792E-4 1.462E-3 1.792E-3 3 69
11 CID000004234 TMPyP Stitch 1.433E-6 2.552E-4 2.081E-3 2.807E-3 3 80
12 CID000003758 IBMX Stitch 2.233E-6 3.563E-4 2.907E-3 4.372E-3 4 368
13 CID000105071 deoxypyridinoline Stitch 2.647E-6 3.563E-4 2.907E-3 5.184E-3 3 98
14 CID000003541 AC1MBZ1C Stitch 2.728E-6 3.563E-4 2.907E-3 5.341E-3 4 387
15 CID000105068 pyridinoline Stitch 2.730E-6 3.563E-4 2.907E-3 5.345E-3 3 99
16 CID000002521 AC1L3C9O Stitch 3.751E-6 4.590E-4 3.744E-3 7.344E-3 3 110
17 CID000096544 8-bromoadenosine Stitch 6.641E-6 7.649E-4 6.239E-3 1.300E-2 3 133
18 CID003674064 mobs Stitch 1.854E-5 2.017E-3 1.645E-2 3.631E-2 2 22
19 CID006426631 Rp-cAMPS Stitch 2.059E-5 2.072E-3 1.690E-2 4.032E-2 3 194
20 1990 UP Diflunisal [22494-42-4]; Up 200; 16uM; HL60; HG-U133A Broad Institute CMAP Up 2.123E-5 2.072E-3 1.690E-2 4.158E-2 3 196
21 892 UP 5162773; Up 200; 7uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 2.222E-5 2.072E-3 1.690E-2 4.351E-2 3 199
22 ctd:D002772 Cholera Toxin CTD 3.488E-5 3.104E-3 2.532E-2
6.829E-2
 2 30
23 CID000010111 mg X Stitch 3.728E-5 3.173E-3 2.589E-2
7.299E-2
 2 31
24 CID000000875 tartarate Stitch 5.280E-5 4.178E-3 3.408E-2
1.034E-1
 3 266
25 CID000107646 O585 Stitch 5.334E-5 4.178E-3 3.408E-2
1.044E-1
 2 37
26 CID000123817 dodecylphosphocholine Stitch 5.933E-5 4.468E-3 3.645E-2
1.162E-1
 2 39
27 CID000106696 Lc 6 Stitch 6.245E-5 4.529E-3 3.694E-2
1.223E-1
 2 40
28 CID000002436 BRL 37344 Stitch 6.891E-5 4.819E-3 3.931E-2
1.349E-1
 2 42
29 ctd:D016226 Phosphorus, Dietary CTD 7.226E-5 4.879E-3 3.980E-2
1.415E-1
 2 43
30 CID000003102 benzophenone Stitch 8.646E-5 5.643E-3 4.603E-2
1.693E-1
 2 47
31 CID000004673 pamidronate Stitch 9.403E-5 5.753E-3 4.693E-2
1.841E-1
 2 49
32 ctd:D010710 Phosphates CTD 9.403E-5 5.753E-3 4.693E-2
1.841E-1
 2 49
33 CID000119371 AC1L3OOT Stitch 9.793E-5 5.811E-3 4.740E-2
1.918E-1
 2 50
34 CID000005631 AC1L1KS5 Stitch 1.038E-4 5.980E-3 4.878E-2
2.033E-1
 3 334
35 CID000002396 GF109203X Stitch 1.114E-4 6.231E-3
5.083E-2
2.181E-1
 3 342
36 CID000002329 BT-PABA Stitch 1.275E-4 6.933E-3
5.655E-2
2.496E-1
 2 57
37 CID000003391 (?-Fluprostenol Stitch 1.461E-4 7.730E-3
6.305E-2
2.860E-1
 2 61
38 CID011979316 vasopressin Stitch 1.618E-4 8.338E-3
6.801E-2
3.168E-1
 3 388
39 CID000003340 fenoldopam Stitch 1.925E-4 8.572E-3
6.993E-2
3.769E-1
 2 70
40 CID000114790 aluminum hydroxide Stitch 2.037E-4 8.572E-3
6.993E-2
3.988E-1
 2 72
41 CID000123828 tyrosine sulfate Stitch 2.094E-4 8.572E-3
6.993E-2
4.100E-1
 2 73
42 CID004469804 AC1NBL8T Stitch 2.643E-4 8.572E-3
6.993E-2
5.174E-1
 2 82
43 CID000173209 ApaI Stitch 2.707E-4 8.572E-3
6.993E-2
5.301E-1
 2 83
44 CID000128366 N-isopropyliodoacetamide Stitch 3.065E-4 8.572E-3
6.993E-2
6.001E-1
 1 1
45 CID000097443 4-nitrophthalonitrile Stitch 3.065E-4 8.572E-3
6.993E-2
6.001E-1
 1 1
46 CID000073182 difluoromethylenediphosphonate Stitch 3.065E-4 8.572E-3
6.993E-2
6.001E-1
 1 1
47 CID003034584 PTH-isoleucine Stitch 3.065E-4 8.572E-3
6.993E-2
6.001E-1
 1 1
48 CID000075659 n-hexyl isocyanate Stitch 3.065E-4 8.572E-3
6.993E-2
6.001E-1
 1 1
49 CID000123827 Tc-99m HEDP Stitch 3.065E-4 8.572E-3
6.993E-2
6.001E-1
 1 1
50 DB05829 Preotact Drug Bank 3.065E-4 8.572E-3
6.993E-2
6.001E-1
 1 1
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 584 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C2932715 Pseudohypoparathyroidism Type 1B DisGeNET Curated 8.525E-13 4.978E-10 3.459E-9 4.978E-10 4 8
2 C1864100 PSEUDOHYPOPARATHYROIDISM, TYPE IB DisGeNET BeFree 1.218E-11 3.556E-9 2.471E-8 7.113E-9 4 14
3 C0020502 Hyperparathyroidism DisGeNET Curated 1.644E-9 3.201E-7 2.224E-6 9.603E-7 4 44
4 C0085682 Hypophosphatemia DisGeNET Curated 2.356E-9 3.439E-7 2.390E-6 1.376E-6 4 48
5 C0553706 SERUM PHOSPHATE ELEVATED DisGeNET Curated 1.793E-8 1.745E-6 1.213E-5 1.047E-5 3 14
6 C2931404 Albright's hereditary osteodystrophy DisGeNET Curated 1.793E-8 1.745E-6 1.213E-5 1.047E-5 3 14
7 C0085681 Hyperphosphatemia (disorder) DisGeNET Curated 7.574E-8 5.529E-6 3.842E-5 4.423E-5 3 22
8 C3494506 Pseudohypoparathyroidism, Type Ia DisGeNET Curated 7.574E-8 5.529E-6 3.842E-5 4.423E-5 3 22
9 C0033806 Pseudohypoparathyroidism DisGeNET Curated 9.951E-8 6.457E-6 4.486E-5 5.811E-5 3 24
10 C1864105 Low urinary cyclic AMP response to PTH administration DisGeNET Curated 1.599E-7 8.063E-6 5.602E-5 9.341E-5 2 2
11 C0268079 Hyperphosphaturia DisGeNET Curated 1.609E-7 8.063E-6 5.602E-5 9.399E-5 3 28
12 C0014132 Endocrine Gland Neoplasms DisGeNET BeFree 1.795E-7 8.063E-6 5.602E-5 1.048E-4 3 29
13 C0035579 Rickets DisGeNET Curated 1.795E-7 8.063E-6 5.602E-5 1.048E-4 3 29
14 OMIN:603233 PSEUDOHYPOPARATHYROIDISM, TYPE IB; PHP1B OMIM 4.797E-7 1.489E-5 1.034E-4 2.802E-4 2 3
15 C0271862 Idiopathic parathyroidism DisGeNET BeFree 4.797E-7 1.489E-5 1.034E-4 2.802E-4 2 3
16 C0265295 Jansen type metaphyseal chondrodysplasia DisGeNET Curated 4.797E-7 1.489E-5 1.034E-4 2.802E-4 2 3
17 C1859148 Chondrodysplasia, blomstrand type DisGeNET Curated 4.797E-7 1.489E-5 1.034E-4 2.802E-4 2 3
18 cv:C1864100 Pseudohypoparathyroidism type 1B Clinical Variations 4.797E-7 1.489E-5 1.034E-4 2.802E-4 2 3
19 C0029464 Osteosclerosis DisGeNET Curated 4.843E-7 1.489E-5 1.034E-4 2.828E-4 3 40
20 C0027709 Nephrocalcinosis DisGeNET Curated 5.625E-7 1.643E-5 1.141E-4 3.285E-4 3 42
21 C0020438 Hypercalciuria DisGeNET Curated 6.487E-7 1.722E-5 1.197E-4 3.789E-4 3 44
22 C0020598 Hypocalcemia DisGeNET Curated 6.487E-7 1.722E-5 1.197E-4 3.789E-4 3 44
23 C0027662 Multiple Endocrine Neoplasia DisGeNET Curated 9.590E-7 2.435E-5 1.692E-4 5.601E-4 3 50
24 C1510497 Lens Opacities DisGeNET Curated 1.385E-6 3.371E-5 2.342E-4 8.090E-4 4 232
25 C3493776 HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 1 DisGeNET Curated 1.598E-6 3.590E-5 2.495E-4 9.335E-4 2 5
26 C2940785 HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 3 DisGeNET Curated 1.598E-6 3.590E-5 2.495E-4 9.335E-4 2 5
27 C0271846 Familial hyperparathyroidism DisGeNET BeFree 2.397E-6 5.185E-5 3.603E-4 1.400E-3 2 6
28 C0392525 Nephrolithiasis DisGeNET Curated 3.423E-6 7.140E-5 4.961E-4 1.999E-3 3 76
29 C0020437 Hypercalcemia DisGeNET Curated 5.332E-6 1.049E-4 7.291E-4 3.114E-3 3 88
30 C1840402 HYPERPARATHYROIDISM 1 DisGeNET Curated 5.750E-6 1.049E-4 7.291E-4 3.358E-3 2 9
31 C0206640 Ossifying Fibroma DisGeNET BeFree 5.750E-6 1.049E-4 7.291E-4 3.358E-3 2 9
32 C0014084 Enchondromatosis DisGeNET Curated 5.750E-6 1.049E-4 7.291E-4 3.358E-3 2 9
33 C0745106 hyperparathyroid DisGeNET BeFree 7.186E-6 1.234E-4 8.576E-4 4.197E-3 2 10
34 C1864729 HYPERPARATHYROIDISM 3 DisGeNET Curated 7.186E-6 1.234E-4 8.576E-4 4.197E-3 2 10
35 C0016063 Osteitis Fibrosa Disseminata DisGeNET Curated 1.053E-5 1.663E-4 1.155E-3 6.152E-3 2 12
36 C0033835 Pseudopseudohypoparathyroidism DisGeNET Curated 1.053E-5 1.663E-4 1.155E-3 6.152E-3 2 12
37 C0265290 Metaphyseal chondrodysplasia DisGeNET Curated 1.053E-5 1.663E-4 1.155E-3 6.152E-3 2 12
38 C0086543 Cataract DisGeNET Curated 1.148E-5 1.741E-4 1.210E-3 6.706E-3 4 395
39 C0025267 Multiple Endocrine Neoplasia Type 1 DisGeNET Curated 1.163E-5 1.741E-4 1.210E-3 6.790E-3 3 114
40 C0282201 Phosphate Diabetes DisGeNET BeFree 1.245E-5 1.817E-4 1.263E-3 7.269E-3 2 13
41 C0149911 Humoral hypercalcemia of malignancy (disorder) DisGeNET BeFree 1.452E-5 2.019E-4 1.403E-3 8.479E-3 2 14
42 C0857973 Increased serum parathyroid hormone DisGeNET Curated 1.452E-5 2.019E-4 1.403E-3 8.479E-3 2 14
43 C0033805 Pseudohypoaldosteronism DisGeNET Curated 1.914E-5 2.599E-4 1.806E-3 1.118E-2 2 16
44 C0220659 Acrodysostosis DisGeNET Curated 2.169E-5 2.878E-4 2.000E-3 1.266E-2 2 17
45 C1704375 Hypophosphatemic Rickets DisGeNET Curated 2.726E-5 3.537E-4 2.458E-3 1.592E-2 2 19
46 C0016663 Pathological fracture DisGeNET Curated 3.028E-5 3.762E-4 2.614E-3 1.768E-2 2 20
47 C3887650 Adult Rickets DisGeNET Curated 3.028E-5 3.762E-4 2.614E-3 1.768E-2 2 20
48 C0030517 Parathyroid Diseases DisGeNET Curated 4.776E-5 5.811E-4 4.037E-3 2.789E-2 2 25
49 C0029442 Osteomalacia DisGeNET Curated 5.173E-5 6.165E-4 4.283E-3 3.021E-2 2 26
50 C3536983 Familial Hypophosphatemic Rickets DisGeNET Curated 5.585E-5 6.484E-4 4.505E-3 3.262E-2 2 27
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