Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc24_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 16 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 6.488E-7 1.038E-5 3.509E-5 1.038E-5 4 357
2 GO:0001205 distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific 2.491E-5 1.993E-4 6.737E-4 3.986E-4 2 30
3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 1.417E-4 7.556E-4 2.554E-3 2.267E-3 2 71
4 GO:0001158 enhancer sequence-specific DNA binding 2.433E-4 8.429E-4 2.850E-3 3.893E-3 2 93
5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 3.043E-4 8.429E-4 2.850E-3 4.868E-3 2 104
6 GO:0035326 enhancer binding 3.161E-4 8.429E-4 2.850E-3 5.057E-3 2 106
7 GO:0001221 transcription cofactor binding 8.013E-3 1.832E-2
6.192E-2
1.282E-1
 1 30
8 GO:0001102 RNA polymerase II activating transcription factor binding 1.014E-2 2.028E-2
6.857E-2
1.623E-1
 1 38
9 GO:0033613 activating transcription factor binding 1.624E-2 2.887E-2
9.760E-2
2.598E-1
 1 61
10 GO:0001078 proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific 3.018E-2 4.541E-2
1.535E-1
4.828E-1
 1 114
11 GO:0001085 RNA polymerase II transcription factor binding 3.122E-2 4.541E-2
1.535E-1
4.996E-1
 1 118
Show 6 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 232 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1903786 regulation of glutathione biosynthetic process 5.369E-4 3.114E-2
1.877E-1
1.246E-1
 1 2
2 GO:1902037 negative regulation of hematopoietic stem cell differentiation 5.369E-4 3.114E-2
1.877E-1
1.246E-1
 1 2
3 GO:1904753 negative regulation of vascular associated smooth muscle cell migration 5.369E-4 3.114E-2
1.877E-1
1.246E-1
 1 2
4 GO:1903788 positive regulation of glutathione biosynthetic process 5.369E-4 3.114E-2
1.877E-1
1.246E-1
 1 2
5 GO:0010499 proteasomal ubiquitin-independent protein catabolic process 1.074E-3 3.425E-2
2.064E-1
2.491E-1
 1 4
6 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress 1.074E-3 3.425E-2
2.064E-1
2.491E-1
 1 4
7 GO:1902036 regulation of hematopoietic stem cell differentiation 1.342E-3 3.425E-2
2.064E-1
3.113E-1
 1 5
8 GO:0034599 cellular response to oxidative stress 1.706E-3 3.425E-2
2.064E-1
3.959E-1
 2 247
9 GO:0051176 positive regulation of sulfur metabolic process 1.878E-3 3.425E-2
2.064E-1
4.357E-1
 1 7
10 GO:0071499 cellular response to laminar fluid shear stress 2.146E-3 3.425E-2
2.064E-1
4.979E-1
 1 8
11 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process 2.146E-3 3.425E-2
2.064E-1
4.979E-1
 1 8
12 GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process 2.682E-3 3.425E-2
2.064E-1
6.223E-1
 1 10
13 GO:1904738 vascular associated smooth muscle cell migration 2.682E-3 3.425E-2
2.064E-1
6.223E-1
 1 10
14 GO:1904752 regulation of vascular associated smooth muscle cell migration 2.682E-3 3.425E-2
2.064E-1
6.223E-1
 1 10
15 GO:2000121 regulation of removal of superoxide radicals 2.950E-3 3.425E-2
2.064E-1
6.844E-1
 1 11
16 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 2.950E-3 3.425E-2
2.064E-1
6.844E-1
 1 11
17 GO:0007596 blood coagulation 3.644E-3 3.425E-2
2.064E-1
8.455E-1
 2 363
18 GO:0007599 hemostasis 3.744E-3 3.425E-2
2.064E-1
8.685E-1
 2 368
19 GO:0050817 coagulation 3.744E-3 3.425E-2
2.064E-1
8.685E-1
 2 368
20 GO:0034616 response to laminar fluid shear stress 3.754E-3 3.425E-2
2.064E-1
8.708E-1
 1 14
21 GO:1904294 positive regulation of ERAD pathway 3.754E-3 3.425E-2
2.064E-1
8.708E-1
 1 14
22 GO:0060218 hematopoietic stem cell differentiation 4.556E-3 3.425E-2
2.064E-1
1.000E0
 1 17
23 GO:0006750 glutathione biosynthetic process 4.824E-3 3.425E-2
2.064E-1
1.000E0
 1 18
24 GO:0014912 negative regulation of smooth muscle cell migration 5.091E-3 3.425E-2
2.064E-1
1.000E0
 1 19
25 GO:0006979 response to oxidative stress 5.289E-3 3.425E-2
2.064E-1
1.000E0
 2 439
26 GO:0036499 PERK-mediated unfolded protein response 5.359E-3 3.425E-2
2.064E-1
1.000E0
 1 20
27 GO:0019184 nonribosomal peptide biosynthetic process 5.359E-3 3.425E-2
2.064E-1
1.000E0
 1 20
28 GO:0010667 negative regulation of cardiac muscle cell apoptotic process 5.626E-3 3.425E-2
2.064E-1
1.000E0
 1 21
29 GO:0071498 cellular response to fluid shear stress 5.626E-3 3.425E-2
2.064E-1
1.000E0
 1 21
30 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 5.626E-3 3.425E-2
2.064E-1
1.000E0
 1 21
31 GO:0042762 regulation of sulfur metabolic process 5.626E-3 3.425E-2
2.064E-1
1.000E0
 1 21
32 GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 5.626E-3 3.425E-2
2.064E-1
1.000E0
 1 21
33 GO:0007567 parturition 5.893E-3 3.425E-2
2.064E-1
1.000E0
 1 22
34 GO:1901032 negative regulation of response to reactive oxygen species 6.161E-3 3.425E-2
2.064E-1
1.000E0
 1 23
35 GO:0006783 heme biosynthetic process 6.161E-3 3.425E-2
2.064E-1
1.000E0
 1 23
36 GO:0019430 removal of superoxide radicals 6.428E-3 3.425E-2
2.064E-1
1.000E0
 1 24
37 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation 6.428E-3 3.425E-2
2.064E-1
1.000E0
 1 24
38 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 6.428E-3 3.425E-2
2.064E-1
1.000E0
 1 24
39 GO:0010664 negative regulation of striated muscle cell apoptotic process 6.695E-3 3.425E-2
2.064E-1
1.000E0
 1 25
40 GO:0071451 cellular response to superoxide 7.229E-3 3.425E-2
2.064E-1
1.000E0
 1 27
41 GO:0090322 regulation of superoxide metabolic process 7.229E-3 3.425E-2
2.064E-1
1.000E0
 1 27
42 GO:1903205 regulation of hydrogen peroxide-induced cell death 7.229E-3 3.425E-2
2.064E-1
1.000E0
 1 27
43 GO:0071450 cellular response to oxygen radical 7.229E-3 3.425E-2
2.064E-1
1.000E0
 1 27
44 GO:0043536 positive regulation of blood vessel endothelial cell migration 7.229E-3 3.425E-2
2.064E-1
1.000E0
 1 27
45 GO:0030194 positive regulation of blood coagulation 7.496E-3 3.425E-2
2.064E-1
1.000E0
 1 28
46 GO:1904292 regulation of ERAD pathway 7.496E-3 3.425E-2
2.064E-1
1.000E0
 1 28
47 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 7.496E-3 3.425E-2
2.064E-1
1.000E0
 1 28
48 GO:1900048 positive regulation of hemostasis 7.496E-3 3.425E-2
2.064E-1
1.000E0
 1 28
49 GO:0036474 cell death in response to hydrogen peroxide 7.763E-3 3.425E-2
2.064E-1
1.000E0
 1 29
50 GO:0006779 porphyrin-containing compound biosynthetic process 7.763E-3 3.425E-2
2.064E-1
1.000E0
 1 29
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 2 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000785 chromatin 6.189E-3 1.238E-2 1.857E-2 1.238E-2 2 487
2 GO:0032993 protein-DNA complex 4.710E-2 4.710E-2
7.064E-2
9.419E-2
 1 183

4: Human Phenotype [Display Chart] 2 input genes in category / 339 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 5 input genes in category / 318 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0013501 increased fibroblast apoptosis 1.914E-4 3.044E-2
1.930E-1
6.088E-2
 2 46
2 MP:0008412 increased cellular sensitivity to oxidative stress 1.914E-4 3.044E-2
1.930E-1
6.088E-2
 2 46
3 MP:0013500 abnormal fibroblast apoptosis 4.195E-4 3.071E-2
1.947E-1
1.334E-1
 2 68
4 MP:0012649 abnormal catalase level 4.829E-4 3.071E-2
1.947E-1
1.535E-1
 1 1
5 MP:0012652 decreased catalase level 4.829E-4 3.071E-2
1.947E-1
1.535E-1
 1 1
6 MP:0000982 abnormal Meissner's corpuscle morphology 9.655E-4 4.886E-2
3.098E-1
3.070E-1
 1 2
7 MP:0000603 pale liver 1.075E-3 4.886E-2
3.098E-1
3.420E-1
 2 109
Show 2 more annotations

6: Domain [Display Chart] 5 input genes in category / 18 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF03131 bZIP Maf Pfam 6.695E-17 6.025E-16 2.106E-15 1.205E-15 5 13
2 IPR004826 bZIP Maf InterPro 6.695E-17 6.025E-16 2.106E-15 1.205E-15 5 13
3 1.10.880.10 - Gene3D 2.272E-16 1.363E-15 4.765E-15 4.090E-15 5 16
4 IPR008917 TF DNA-bd InterPro 2.267E-14 1.020E-13 3.566E-13 4.081E-13 5 37
5 SM00338 BRLZ SMART 1.352E-13 3.701E-13 1.294E-12 2.433E-12 5 52
6 PS00036 BZIP BASIC PROSITE 1.493E-13 3.701E-13 1.294E-12 2.687E-12 5 53
7 PS50217 BZIP PROSITE 1.493E-13 3.701E-13 1.294E-12 2.687E-12 5 53
8 IPR004827 bZIP InterPro 1.645E-13 3.701E-13 1.294E-12 2.961E-12 5 54
9 PF00170 bZIP 1 Pfam 5.447E-8 1.089E-7 3.808E-7 9.805E-7 3 34
10 IPR024874 Transciption factor Maf fam InterPro 1.196E-6 2.153E-6 7.524E-6 2.153E-5 2 7
11 IPR028573 Maf/V-MAF InterPro 2.669E-4 3.203E-4 1.119E-3 4.804E-3 1 1
12 IPR029845 Nrf2 InterPro 2.669E-4 3.203E-4 1.119E-3 4.804E-3 1 1
13 IPR033531 MafF InterPro 2.669E-4 3.203E-4 1.119E-3 4.804E-3 1 1
14 IPR029854 NF2L3 InterPro 2.669E-4 3.203E-4 1.119E-3 4.804E-3 1 1
15 IPR029847 Nrf1 InterPro 2.669E-4 3.203E-4 1.119E-3 4.804E-3 1 1
16 PF08383 Maf N Pfam 1.067E-3 1.130E-3 3.949E-3 1.921E-2 1 4
17 IPR013592 Maf TF N InterPro 1.067E-3 1.130E-3 3.949E-3 1.921E-2 1 4
18 PF07716 bZIP 2 Pfam 4.529E-3 4.529E-3 1.583E-2
8.153E-2
 1 17
Show 13 more annotations

7: Pathway [Display Chart] 3 input genes in category / 10 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M14339 Oxidative Stress Induced Gene Expression Via Nrf2 MSigDB C2 BIOCARTA (v6.0) 3.130E-3 1.925E-2
5.639E-2
 3.130E-2 1 13
2 M1394 GATA3 participate in activating the Th2 cytokine genes expression MSigDB C2 BIOCARTA (v6.0) 3.851E-3 1.925E-2
5.639E-2
 3.851E-2 1 16
3 137993 Calcineurin-regulated NFAT-dependent transcription in lymphocytes BioSystems: Pathway Interaction Database 1.152E-2 3.668E-2
1.074E-1
1.152E-1
 1 48
4 842771 Inflammatory bowel disease (IBD) BioSystems: KEGG 1.558E-2 3.668E-2
1.074E-1
1.558E-1
 1 65
5 138073 C-MYB transcription factor network BioSystems: Pathway Interaction Database 1.868E-2 3.668E-2
1.074E-1
1.868E-1
 1 78
6 1458885 Th1 and Th2 cell differentiation BioSystems: KEGG 2.201E-2 3.668E-2
1.074E-1
2.201E-1
 1 92
7 1474302 Fluid shear stress and atherosclerosis BioSystems: KEGG 3.383E-2 4.275E-2
1.252E-1
3.383E-1
 1 142
8 1269377 Factors involved in megakaryocyte development and platelet production BioSystems: REACTOME 3.736E-2 4.275E-2
1.252E-1
3.736E-1
 1 157
9 167325 Protein processing in endoplasmic reticulum BioSystems: KEGG 3.947E-2 4.275E-2
1.252E-1
3.947E-1
 1 166
10 523016 Transcriptional misregulation in cancer BioSystems: KEGG 4.275E-2 4.275E-2
1.252E-1
4.275E-1
 1 180
Show 5 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 2356 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 23661758 Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Pubmed 6.438E-16 1.517E-12 1.265E-11 1.517E-12 5 37
2 10037736 Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. Pubmed 1.077E-11 8.458E-9 7.056E-8 2.537E-8 3 5
3 25130429 Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis. Pubmed 1.077E-11 8.458E-9 7.056E-8 2.537E-8 3 5
4 20102225 Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Pubmed 5.336E-9 2.692E-6 2.246E-5 1.257E-5 3 32
5 24462598 The role of Nrf1 and Nrf2 in the regulation of copper-responsive transcription. Pubmed 1.371E-8 2.692E-6 2.246E-5 3.230E-5 2 2
6 17609210 The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription. Pubmed 1.371E-8 2.692E-6 2.246E-5 3.230E-5 2 2
7 27060105 Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity. Pubmed 1.371E-8 2.692E-6 2.246E-5 3.230E-5 2 2
8 21216956 Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small Maf proteins. Pubmed 1.371E-8 2.692E-6 2.246E-5 3.230E-5 2 2
9 12968018 Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. Pubmed 1.371E-8 2.692E-6 2.246E-5 3.230E-5 2 2
10 18585411 Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif. Pubmed 1.371E-8 2.692E-6 2.246E-5 3.230E-5 2 2
11 24466341 Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cells. Pubmed 1.371E-8 2.692E-6 2.246E-5 3.230E-5 2 2
12 17875642 Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer. Pubmed 1.371E-8 2.692E-6 2.246E-5 3.230E-5 2 2
13 29149604 NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis. Pubmed 4.113E-8 5.700E-6 4.755E-5 9.691E-5 2 3
14 25092871 Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes. Pubmed 4.113E-8 5.700E-6 4.755E-5 9.691E-5 2 3
15 16872277 Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. Pubmed 4.113E-8 5.700E-6 4.755E-5 9.691E-5 2 3
16 15060151 Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. Pubmed 4.113E-8 5.700E-6 4.755E-5 9.691E-5 2 3
17 7726861 cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor. Pubmed 4.113E-8 5.700E-6 4.755E-5 9.691E-5 2 3
18 18826952 Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. Pubmed 8.226E-8 9.229E-6 7.699E-5 1.938E-4 2 4
19 21262351 Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. Pubmed 8.226E-8 9.229E-6 7.699E-5 1.938E-4 2 4
20 16581765 Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Pubmed 8.226E-8 9.229E-6 7.699E-5 1.938E-4 2 4
21 15087497 Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Pubmed 8.226E-8 9.229E-6 7.699E-5 1.938E-4 2 4
22 26078718 NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence. Pubmed 1.371E-7 1.154E-5 9.623E-5 3.230E-4 2 5
23 9558405 Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2. Pubmed 1.371E-7 1.154E-5 9.623E-5 3.230E-4 2 5
24 9150357 Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. Pubmed 1.371E-7 1.154E-5 9.623E-5 3.230E-4 2 5
25 8932385 Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1. Pubmed 1.371E-7 1.154E-5 9.623E-5 3.230E-4 2 5
26 16135796 Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes. Pubmed 1.371E-7 1.154E-5 9.623E-5 3.230E-4 2 5
27 9224592 The world according to Maf. Pubmed 1.371E-7 1.154E-5 9.623E-5 3.230E-4 2 5
28 16785233 Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer. Pubmed 1.371E-7 1.154E-5 9.623E-5 3.230E-4 2 5
29 11025215 Expression of the bZIP transcription factor TCF11 and its potential dimerization partners during development. Pubmed 2.056E-7 1.563E-5 1.304E-4 4.845E-4 2 6
30 9872330 Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Pubmed 2.056E-7 1.563E-5 1.304E-4 4.845E-4 2 6
31 22586274 NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes. Pubmed 2.056E-7 1.563E-5 1.304E-4 4.845E-4 2 6
32 14517290 Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Pubmed 2.879E-7 1.995E-5 1.664E-4 6.782E-4 2 7
33 12490281 Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation. Pubmed 2.879E-7 1.995E-5 1.664E-4 6.782E-4 2 7
34 23737527 Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene. Pubmed 2.879E-7 1.995E-5 1.664E-4 6.782E-4 2 7
35 11036080 A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities. Pubmed 3.838E-7 2.512E-5 2.095E-4 9.042E-4 2 8
36 7567998 Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Pubmed 3.838E-7 2.512E-5 2.095E-4 9.042E-4 2 8
37 20300111 Jun and JunD-dependent functions in cell proliferation and stress response. Pubmed 1.863E-6 1.186E-4 9.897E-4 4.390E-3 2 17
38 12805554 Comprehensive identification of human bZIP interactions with coiled-coil arrays. Pubmed 3.465E-6 2.148E-4 1.792E-3 8.164E-3 2 23
39 24140708 Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription. Pubmed 4.451E-6 2.689E-4 2.243E-3 1.049E-2 2 26
40 27374075 Genetic variants of nuclear factor erythroid-derived 2-like 2 associated with the complications in Han descents with type 2 diabetes mellitus of Northeast China. Pubmed 1.309E-4 3.072E-4 2.563E-3
3.084E-1
 1 1
41 23738044 The influence of Nrf2 on cardiac responses to environmental stressors. Pubmed 1.309E-4 3.072E-4 2.563E-3
3.084E-1
 1 1
42 19592468 Nrf2 protects against maladaptive cardiac responses to hemodynamic stress. Pubmed 1.309E-4 3.072E-4 2.563E-3
3.084E-1
 1 1
43 20417615 Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway. Pubmed 1.309E-4 3.072E-4 2.563E-3
3.084E-1
 1 1
44 23587556 The role of the Nrf2-mediated defense system in corneal epithelial wound healing. Pubmed 1.309E-4 3.072E-4 2.563E-3
3.084E-1
 1 1
45 9501099 Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. Pubmed 1.309E-4 3.072E-4 2.563E-3
3.084E-1
 1 1
46 17336276 Nrf2-mediated protection against 6-hydroxydopamine. Pubmed 1.309E-4 3.072E-4 2.563E-3
3.084E-1
 1 1
47 23570914 Suppression of nuclear factor erythroid 2-related factor 2 via extracellular signal-regulated kinase contributes to bleomycin-induced oxidative stress and fibrogenesis. Pubmed 1.309E-4 3.072E-4 2.563E-3
3.084E-1
 1 1
48 26689473 Nrf2 antioxidant defense is involved in survival signaling elicited by 27-hydroxycholesterol in human promonocytic cells. Pubmed 1.309E-4 3.072E-4 2.563E-3
3.084E-1
 1 1
49 20085761 Nrf3-deficient mice are not protected against acute lung and adipose tissue damages induced by butylated hydroxytoluene. Pubmed 1.309E-4 3.072E-4 2.563E-3
3.084E-1
 1 1
50 27683801 Cell-specific Activation of the Nrf2 Antioxidant Pathway Increases Mucosal Inflammation in Acute but Not in Chronic Colitis. Pubmed 1.309E-4 3.072E-4 2.563E-3
3.084E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 127 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MAFG MAFG interactions 1.173E-14 1.490E-12 8.084E-12 1.490E-12 5 31
2 int:NFE2L3 NFE2L3 interactions 1.223E-12 7.765E-11 4.213E-10 1.553E-10 4 14
3 int:MAFF MAFF interactions 8.060E-11 3.412E-9 1.851E-8 1.024E-8 4 37
4 int:NFE2L2 NFE2L2 interactions 1.402E-9 4.451E-8 2.415E-7 1.780E-7 4 74
5 int:BACH2 BACH2 interactions 8.815E-9 2.239E-7 1.215E-6 1.120E-6 3 18
6 int:MAFK MAFK interactions 2.185E-8 4.626E-7 2.510E-6 2.775E-6 3 24
7 int:NFE2L1 NFE2L1 interactions 3.157E-8 5.728E-7 3.108E-6 4.010E-6 3 27
8 int:ATF4 ATF4 interactions 1.061E-6 1.497E-5 8.122E-5 1.347E-4 3 85
9 int:NFE2 NFE2 interactions 1.061E-6 1.497E-5 8.122E-5 1.347E-4 3 85
10 int:PPARG PPARG interactions 6.626E-6 8.415E-5 4.566E-4 8.415E-4 3 156
11 int:HOXD12 HOXD12 interactions 8.665E-6 1.000E-4 5.428E-4 1.100E-3 2 17
12 int:FOS FOS interactions 9.520E-6 1.008E-4 5.466E-4 1.209E-3 3 176
13 int:NRF1 NRF1 interactions 2.405E-5 2.343E-4 1.271E-3 3.055E-3 2 28
14 int:MAF MAF interactions 2.583E-5 2.343E-4 1.271E-3 3.281E-3 2 29
15 int:JUN JUN interactions 4.514E-5 3.822E-4 2.073E-3 5.733E-3 3 296
16 int:GSK3B GSK3B interactions 6.414E-5 5.091E-4 2.762E-3 8.146E-3 3 333
17 int:JUND JUND interactions 1.012E-4 7.562E-4 4.103E-3 1.286E-2 2 57
18 int:AHR AHR interactions 1.238E-4 8.540E-4 4.633E-3 1.572E-2 2 63
19 int:BACH1 BACH1 interactions 1.278E-4 8.540E-4 4.633E-3 1.623E-2 2 64
20 int:HCFC1 HCFC1 interactions 4.348E-4 2.761E-3 1.498E-2
5.522E-2
 2 118
21 int:KEAP1 KEAP1 interactions 5.855E-4 3.541E-3 1.921E-2
7.436E-2
 2 137
22 int:MAFIP MAFIP interactions 1.129E-3 6.520E-3 3.537E-2
1.434E-1
 1 4
23 int:CREB3 CREB3 interactions 1.527E-3 8.432E-3 4.575E-2
1.939E-1
 2 222
24 int:OVOL1 OVOL1 interactions 1.694E-3 8.962E-3 4.862E-2
2.151E-1
 1 6
25 int:PAQR3 PAQR3 interactions 1.976E-3 1.004E-2
5.445E-2
2.509E-1
 1 7
26 int:PRRX1 PRRX1 interactions 2.258E-3 1.024E-2
5.556E-2
2.867E-1
 1 8
27 int:CD6 CD6 interactions 2.258E-3 1.024E-2
5.556E-2
2.867E-1
 1 8
28 int:RTL6 RTL6 interactions 2.258E-3 1.024E-2
5.556E-2
2.867E-1
 1 8
29 int:FBXW7 FBXW7 interactions 3.478E-3 1.523E-2
8.264E-2
4.418E-1
 2 337
30 int:HDAC2 HDAC2 interactions 4.357E-3 1.659E-2
9.000E-2
5.534E-1
 2 378
31 int:ENC1 ENC1 interactions 4.511E-3 1.659E-2
9.000E-2
5.729E-1
 1 16
32 int:BRD9 BRD9 interactions 4.511E-3 1.659E-2
9.000E-2
5.729E-1
 1 16
33 int:CREBBP CREBBP interactions 4.820E-3 1.659E-2
9.000E-2
6.122E-1
 2 398
34 int:BTRC BTRC interactions 4.939E-3 1.659E-2
9.000E-2
6.273E-1
 2 403
35 int:NFIL3 NFIL3 interactions 5.074E-3 1.659E-2
9.000E-2
6.444E-1
 1 18
36 int:CREBZF CREBZF interactions 5.074E-3 1.659E-2
9.000E-2
6.444E-1
 1 18
37 int:BATF2 BATF2 interactions 5.074E-3 1.659E-2
9.000E-2
6.444E-1
 1 18
38 int:FBXW11 FBXW11 interactions 5.109E-3 1.659E-2
9.000E-2
6.488E-1
 2 410
39 int:CHD6 CHD6 interactions 5.355E-3 1.659E-2
9.000E-2
6.801E-1
 1 19
40 int:RUSC2 RUSC2 interactions 5.355E-3 1.659E-2
9.000E-2
6.801E-1
 1 19
41 int:MAFA MAFA interactions 5.355E-3 1.659E-2
9.000E-2
6.801E-1
 1 19
42 int:MAFB MAFB interactions 6.480E-3 1.959E-2
1.063E-1
8.230E-1
 1 23
43 int:SOX9 SOX9 interactions 7.323E-3 2.163E-2
1.173E-1
9.300E-1
 1 26
44 int:PPP1R13L PPP1R13L interactions 8.165E-3 2.357E-2
1.279E-1
1.000E0
 1 29
45 int:NQO1 NQO1 interactions 8.726E-3 2.434E-2
1.320E-1
1.000E0
 1 31
46 int:GTF2A1L GTF2A1L interactions 9.006E-3 2.434E-2
1.320E-1
1.000E0
 1 32
47 int:USF2 USF2 interactions 9.006E-3 2.434E-2
1.320E-1
1.000E0
 1 32
48 int:HCFC2 HCFC2 interactions 9.567E-3 2.531E-2
1.373E-1
1.000E0
 1 34
49 int:FOSL1 FOSL1 interactions 1.013E-2 2.610E-2
1.416E-1
1.000E0
 1 36
50 int:PHF12 PHF12 interactions 1.069E-2 2.610E-2
1.416E-1
1.000E0
 1 38
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16q22-q23 16q22-q23 1.443E-4 7.213E-4 1.647E-3 7.213E-4 1 1
2 2q31 2q31 1.874E-3 3.843E-3 8.776E-3 9.370E-3 1 13
3 17q21.3 17q21.3 2.306E-3 3.843E-3 8.776E-3 1.153E-2 1 16
4 7p15.2 7p15.2 6.188E-3 7.735E-3 1.766E-2 3.094E-2 1 43
5 22q13.1 22q13.1 1.277E-2 1.277E-2 2.917E-2
6.387E-2
 1 89

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 91 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TCANNTGAY V$SREBP1 01 TCANNTGAY V$SREBP1 01 5.421E-4 3.165E-2
1.612E-1
 4.934E-2 3 378
2 TGACGTCA V$ATF3 Q6 TGACGTCA V$ATF3 Q6 3.545E-3 3.165E-2
1.612E-1
3.226E-1
 2 188
3 V$ATF1 Q6 V$ATF1 Q6 3.657E-3 3.165E-2
1.612E-1
3.328E-1
 2 191
4 V$CREBP1 Q2 V$CREBP1 Q2 3.848E-3 3.165E-2
1.612E-1
3.501E-1
 2 196
5 V$DR1 Q3 V$DR1 Q3 3.886E-3 3.165E-2
1.612E-1
3.537E-1
 2 197
6 V$SREBP Q3 V$SREBP Q3 4.043E-3 3.165E-2
1.612E-1
3.679E-1
 2 201
7 V$CREB Q4 V$CREB Q4 4.122E-3 3.165E-2
1.612E-1
3.751E-1
 2 203
8 V$CREB Q2 V$CREB Q2 4.283E-3 3.165E-2
1.612E-1
3.898E-1
 2 207
9 AAAYWAACM V$HFH4 01 AAAYWAACM V$HFH4 01 4.365E-3 3.165E-2
1.612E-1
3.972E-1
 2 209
10 V$SOX5 01 V$SOX5 01 4.488E-3 3.165E-2
1.612E-1
4.085E-1
 2 212
11 V$CREB 01 V$CREB 01 4.488E-3 3.165E-2
1.612E-1
4.085E-1
 2 212
12 V$CREBP1CJUN 01 V$CREBP1CJUN 01 4.530E-3 3.165E-2
1.612E-1
4.122E-1
 2 213
13 V$P53 DECAMER Q2 V$P53 DECAMER Q2 4.572E-3 3.165E-2
1.612E-1
4.160E-1
 2 214
14 V$E4F1 Q6 V$E4F1 Q6 4.870E-3 3.165E-2
1.612E-1
4.431E-1
 2 221
Show 9 more annotations

12: Gene Family [Display Chart] 5 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 506 Basic leucine zipper proteins genenames.org 1.148E-13 1.148E-13 1.148E-13 1.148E-13 5 49

13: Coexpression [Display Chart] 5 input genes in category / 991 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M14118 Genes up-regulated in HL-60 cells (promyeloid leukemia) by cantharidin [PubChem=6708701]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.380E-6 3.976E-3 2.973E-2 6.322E-3 2 19
2 M262 Genes discriminating responses to sodium arsenite [PubChem=26435] from other stresses. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.025E-6 3.976E-3 2.973E-2 7.953E-3 3 217
3 M7623 Genes down-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.741E-5 4.788E-3 3.580E-2 1.725E-2 3 281
4 M6890 Genes down-regulated in at least one of three multiple myeloma (MM) cell lines by TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.933E-5 4.788E-3 3.580E-2 1.915E-2 3 291
5 18172295-SuppTable4 Human Bone Heller08 693genes GeneSigDB 3.650E-5 7.235E-3
5.409E-2
 3.617E-2 3 360
6 M7928 Genes up-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164], a marine-derived compound with potential anti-cancer properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.595E-5 9.951E-3
7.439E-2
6.535E-2
 3 439
7 M15542 Genes up-regulated in pre B lymphocyte after induction of physiological DNA double-strand breaks (DSB) by RAG2 [GeneID=5897]; the changes are independent of ATM [GeneID=472] signaling. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.029E-5 9.951E-3
7.439E-2
6.965E-2
 2 62
8 M1513 Up-regulated in the neocortex of aged (30-month) mice subjected to caloric restriction since young adulthood. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.263E-4 1.187E-2
8.877E-2
1.251E-1
 2 83
9 M3185 Genes down-regulated in at least one of three multiple myeloma (MM) cell lines treated with the DNA hypomethylating agent decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.022E-4 1.187E-2
8.877E-2
2.004E-1
 2 105
10 M1348 Genes up-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 12 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.468E-4 1.187E-2
8.877E-2
2.445E-1
 2 116
11 M5888 Cluster 2: late ATM [GeneID=472] dependent genes induced by ionizing radiation treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.957E-4 1.187E-2
8.877E-2
2.931E-1
 2 127
12 M2801 Genes down-regulated in primary keratinocytes from RB1 and RBL1 [Gene ID=5925, 5933] skin specific knockout mice. MSigDB C6: Oncogenic Signatures (v6.0) 3.004E-4 1.187E-2
8.877E-2
2.977E-1
 2 128
13 17344918-SuppTable1 Human Leukemia Corre07 163genes GeneSigDB 3.390E-4 1.187E-2
8.877E-2
3.360E-1
 2 136
14 M6498 Genes up-regulated in monocyte-derived dendritic cells: control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 3.959E-4 1.187E-2
8.877E-2
3.924E-1
 2 147
15 M16336 Up-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042], a tyrosine kinase inhibitor with anticancer properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.959E-4 1.187E-2
8.877E-2
3.924E-1
 2 147
16 M11513 Genes down-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.344E-4 1.187E-2
8.877E-2
4.305E-1
 2 154
17 M7116 Genes up-regulated in CD4 [GeneID=920] T cells: control versus treated with halofuginone [PubChem=400772] for 3h. MSigDB C7: Immunologic Signatures (v6.0) 4.457E-4 1.187E-2
8.877E-2
4.417E-1
 2 156
18 20062080-Table3 Human Breast Bauer10 05genes GeneSigDB 6.482E-4 1.187E-2
8.877E-2
6.424E-1
 1 3
19 M2819 Genes up-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 [Gene ID=3558] and then stimulated with IL15 [Gene ID=3600]. MSigDB C6: Oncogenic Signatures (v6.0) 6.600E-4 1.187E-2
8.877E-2
6.541E-1
 2 190
20 M6075 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (2h) versus IL-12 (2h). MSigDB C7: Immunologic Signatures (v6.0) 7.092E-4 1.187E-2
8.877E-2
7.029E-1
 2 197
21 M5873 Genes up-regulated in comparison of monocytes treated with 1 ng/ml LPS (TLR4 agonist) versus untreated monocytes. MSigDB C7: Immunologic Signatures (v6.0) 7.092E-4 1.187E-2
8.877E-2
7.029E-1
 2 197
22 M5342 Genes down-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 0 h versus PMN treated with F. tularensis vaccine at 3 h. MSigDB C7: Immunologic Signatures (v6.0) 7.092E-4 1.187E-2
8.877E-2
7.029E-1
 2 197
23 M4729 Genes up-regulated in comparison of dendritic cells (DC) stimulated with R848 at 2 h versus DCs stimulatd with R848 for 8 h. MSigDB C7: Immunologic Signatures (v6.0) 7.164E-4 1.187E-2
8.877E-2
7.100E-1
 2 198
24 M5867 Genes up-regulated in comparison of monocytes treated with 1 ng/ml LPS (TLR4 agonist) versus monocytes treated with control IgG. MSigDB C7: Immunologic Signatures (v6.0) 7.164E-4 1.187E-2
8.877E-2
7.100E-1
 2 198
25 M3149 Genes down-regulated in comparison of macrophages cultured with M-CSF [GeneID=1435] and Pam3Cyc versus macrophages cultured with M-CSF [GeneID=1435], IFNG [GeneID=3458] and Pam3Cyc. MSigDB C7: Immunologic Signatures (v6.0) 7.164E-4 1.187E-2
8.877E-2
7.100E-1
 2 198
26 M5790 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with type 1 diabetes at 1 month after the diagnosis versus those at 4 months later. MSigDB C7: Immunologic Signatures (v6.0) 7.164E-4 1.187E-2
8.877E-2
7.100E-1
 2 198
27 M7142 Genes up-regulated in CD8A- [GeneID=925] splenic dendritic cells: IFNAR1 [GeneID=3454] knockout versus IFNB1 [GeneID=3456] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 1.187E-2
8.877E-2
7.171E-1
 2 199
28 M6119 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL4 [GeneID=3565] (6h) versus untreated (6h). MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 1.187E-2
8.877E-2
7.171E-1
 2 199
29 M4437 Genes up-regulated in comparison of memory IgG IgA B cells versus memory IgM B cells. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 1.187E-2
8.877E-2
7.171E-1
 2 199
30 M8737 Genes up-regulated in STAT5 double knock-in T cells: control versus IL2 [GeneID=3558] stimulation for 6h. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 1.187E-2
8.877E-2
7.171E-1
 2 199
31 M7021 Genes up-regulated in lymphoid-primed multipotent progenitors versus granulo-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 1.187E-2
8.877E-2
7.171E-1
 2 199
32 M3060 Genes up-regulated in comparison of memory CD8 T cells versus effector CD8 T cells KLRG1 high [GeneID=10219]. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 1.187E-2
8.877E-2
7.171E-1
 2 199
33 M9568 Genes up-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 [GeneID=10219] knockout versus BCL2L11 [GeneID=10018] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 1.187E-2
8.877E-2
7.171E-1
 2 199
34 M9187 Genes up-regulated in CD4 T conv over-expressing: FOXP3 [GeneID=50943] versus LEF1 and FOXP3 [GeneID=51176;50943]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
35 M7233 Genes up-regulated in T cells: control (0h) versus IL21 [GeneID=59067] for 24h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
36 M4476 Genes down-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated dendritic cells (DC). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
37 M7020 Genes up-regulated in IKZF1 [GeneID=10320] knockout: hematopoietic stem cells versus megakaryo-erythrocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
38 M7783 Genes up-regulated in memory CD8 T cells: wildtype versus TCF7 [GeneID=6932] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
39 M6661 Genes up-regulated in bone marrow-derived macrophages (45 min): IL6 [GeneID=3469] knockout stimulated by IL6 [GeneID=3469] and LPS versus IL10 [GeneID=3486] knockout stimulated by and IL6 [GeneID=3469] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
40 M9572 Genes up-regulated in cells from peripheral lymph nodes: T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
41 M5856 Genes up-regulated in comparison of monocytes treated with 5000 ng/ml LPS (TLR4 agonist) versus monocytes treated with anti-TREM1 [GeneID=54210]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
42 M5766 Genes up-regulated in comparison of untreated macrophages versus those treated with IL1 and IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
43 M3685 Genes down-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with LPS (TLR4 agonist) at 1 h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
44 M3073 Genes up-regulated in comparison of memory CD8 T cells versus effector CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
45 M8053 Genes up-regulated in macrophages: wildtype versus PPARG [GeneID=5468] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
46 M4233 Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 72 h versus the untreated cells at 72 h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
47 M9598 Genes up-regulated in T conv: peripheral lymph nodes versus thymic CD24 high [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
48 M3098 Genes up-regulated in comparison of dendritic cells activated in the absense of VAF347 [PubChem=10172275] versus those activated in the presence of VAF347 [PubChem=10172275]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
49 M6092 Genes up-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 and then stimulated by IL-12 (6h). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
50 M9660 Genes up-regulated in CD4 [GeneID=920] T helper cells Th0: 1h versus 20h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.187E-2
8.877E-2
7.243E-1
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 900 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 200 k3 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.361E-5 1.225E-2
9.041E-2
 1.225E-2 2 26
2 gudmap developingLowerUrinaryTract P1 ureter 200 k3 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.327E-5 1.947E-2
1.437E-1
 3.894E-2 2 46
3 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 200 k4 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 9.504E-5 2.697E-2
1.990E-1
8.554E-2
 2 68
4 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 500 k4 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.522E-4 2.697E-2
1.990E-1
1.370E-1
 2 86
5 gudmap developingLowerUrinaryTract P1 ureter 500 k5 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.898E-4 2.697E-2
1.990E-1
1.708E-1
 2 96
6 gudmap developingLowerUrinaryTract P1 bladder J 500 k3 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.059E-4 2.697E-2
1.990E-1
1.853E-1
 2 100
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Proliferating NK cell/Kidney Normal-Cortex Wilms Proliferating NK cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Proliferating NK cell/Kidney Normal-Cortex Wilms Proliferating NK cell Adult, Development, and Cancer types 2.446E-4 2.697E-2
1.990E-1
2.202E-1
 2 109
8 Sample Type by Project: Shred 1/TCGA-Prostate/Prostate Adenocarcinoma /Acinar Adenocarcinoma/1/0 Sample Type by Project: Shred 1/TCGA-Prostate/Prostate Adenocarcinoma /Acinar Adenocarcinoma/1/0 TCGA-Prostate 2.676E-4 2.697E-2
1.990E-1
2.408E-1
 2 114
9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Cortex Wilms IF-U/Kidney Normal-Cortex Wilms IF14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Cortex Wilms IF-U/Kidney Normal-Cortex Wilms IF14 Adult, Development, and Cancer types 2.818E-4 2.697E-2
1.990E-1
2.537E-1
 2 117
10 gudmap developingLowerUrinaryTract P1 bladder B 1000 k3 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.115E-4 2.697E-2
1.990E-1
2.803E-1
 2 123
11 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 500 k5 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.586E-4 2.697E-2
1.990E-1
3.227E-1
 2 132
12 gudmap developingLowerUrinaryTract P1 ureter 1000 k5 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.975E-4 2.697E-2
1.990E-1
3.578E-1
 2 139
13 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Angpt2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Angpt2 BrainMap 4.445E-4 2.697E-2
1.990E-1
4.000E-1
 2 147
14 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 200 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.751E-4 2.697E-2
1.990E-1
4.276E-1
 2 152
15 gudmap developingLowerUrinaryTract P1 ureter 200 DevelopingLowerUrinaryTract P1 ureter emap-30363 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.068E-4 2.697E-2
1.990E-1
4.561E-1
 2 157
16 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 1000 k1 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.068E-4 2.697E-2
1.990E-1
4.561E-1
 2 157
17 gudmap developingLowerUrinaryTract P1 bladder J 1000 k3 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.262E-4 2.697E-2
1.990E-1
4.736E-1
 2 160
18 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 200 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.394E-4 2.697E-2
1.990E-1
4.855E-1
 2 162
19 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 200 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.868E-4 2.780E-2
2.051E-1
5.281E-1
 2 169
20 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour PapRCC NK cell/Kidney Tumour PapRCC NK7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour PapRCC NK cell/Kidney Tumour PapRCC NK7 Adult, Development, and Cancer types 7.330E-4 3.015E-2
2.225E-1
6.597E-1
 2 189
21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal Wilms U U/Kidney Normal Wilms U21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal Wilms U U/Kidney Normal Wilms U21 Adult, Development, and Cancer types 7.563E-4 3.015E-2
2.225E-1
6.807E-1
 2 192
22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal Wilms NK cell/Kidney Normal Wilms NK21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal Wilms NK cell/Kidney Normal Wilms NK21 Adult, Development, and Cancer types 7.642E-4 3.015E-2
2.225E-1
6.878E-1
 2 193
23 Immune cells (IMM)/Immune cells (IMM) l Immune cells (IMM)/Immune cells (IMM) l 7.800E-4 3.015E-2
2.225E-1
7.020E-1
 2 195
24 Loop of Henle (LH) Loop of Henle (LH) 8.040E-4 3.015E-2
2.225E-1
7.236E-1
 2 198
25 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k5 100 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k-means-cluster#5 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.145E-3 4.121E-2
3.042E-1
1.000E0
 1 5
26 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 1000 k2 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.412E-3 4.887E-2
3.607E-1
1.000E0
 2 263
27 gudmap developingLowerUrinaryTract e14.5 urethra 100 k5 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#5 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.602E-3 4.995E-2
3.686E-1
1.000E0
 1 7
28 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 100 k5 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 k-means-cluster#5 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.602E-3 4.995E-2
3.686E-1
1.000E0
 1 7
29 Facebase RNAseq ratio e10.5 MandibularArch vs MaxillaryArch 2500 K2 FacebaseRNAseq ratio e10.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 2500 k-means-cluster#2 FaceBase_RNAseq 1.609E-3 4.995E-2
3.686E-1
1.000E0
 2 281
Show 24 more annotations

15: Computational [Display Chart] 5 input genes in category / 23 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M4051 MODULE 1 Ovary genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.627E-4 1.064E-2 3.974E-2 1.064E-2 3 368

16: MicroRNA [Display Chart] 5 input genes in category / 302 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-342-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.104E-5 6.101E-3 3.837E-2 9.374E-3 2 128
2 hsa-miR-6514-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.040E-5 6.101E-3 3.837E-2 1.220E-2 2 146
3 AACTGGA,MIR-145:MSigDB AACTGGA,MIR-145:MSigDB MSigDB 9.598E-5 8.999E-3
5.659E-2
 2.899E-2 2 225
4 hsa-miR-224-5p:TargetScan hsa-miR-224-5p TargetScan 1.963E-4 8.999E-3
5.659E-2
5.929E-2
 2 322
5 hsa-miR-338-3p:TargetScan hsa-miR-338-3p TargetScan 2.099E-4 8.999E-3
5.659E-2
6.339E-2
 2 333
6 hsa-miR-31*:mirSVR highEffct hsa-miR-31*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.438E-4 8.999E-3
5.659E-2
7.364E-2
 2 359
7 hsa-miR-504-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.891E-4 8.999E-3
5.659E-2
8.730E-2
 2 391
8 hsa-miR-3135b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.935E-4 8.999E-3
5.659E-2
8.864E-2
 2 394
9 hsa-miR-4430:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.980E-4 8.999E-3
5.659E-2
8.999E-2
 2 397
10 hsa-miR-3652:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.980E-4 8.999E-3
5.659E-2
8.999E-2
 2 397
11 hsa-miR-760:TargetScan hsa-miR-760 TargetScan 3.397E-4 9.326E-3
5.865E-2
1.026E-1
 2 424
12 hsa-miR-653-5p:TargetScan hsa-miR-653-5p TargetScan 3.723E-4 9.370E-3
5.893E-2
1.124E-1
 2 444
13 GCGCTTT,MIR-518D:MSigDB GCGCTTT,MIR-518D:MSigDB MSigDB 1.314E-3 2.520E-2
1.585E-1
3.969E-1
 1 19
14 GCGCTTT,MIR-518C:MSigDB GCGCTTT,MIR-518C:MSigDB MSigDB 1.314E-3 2.520E-2
1.585E-1
3.969E-1
 1 19
15 GCGCTTT,MIR-518B:MSigDB GCGCTTT,MIR-518B:MSigDB MSigDB 1.314E-3 2.520E-2
1.585E-1
3.969E-1
 1 19
16 hsa-miR-132-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.522E-3 2.520E-2
1.585E-1
4.596E-1
 1 22
17 hsa-miR-3621:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.660E-3 2.520E-2
1.585E-1
5.013E-1
 1 24
18 hsa-miR-6798-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.937E-3 2.520E-2
1.585E-1
5.848E-1
 1 28
19 hsa-miR-4540:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.006E-3 2.520E-2
1.585E-1
6.057E-1
 1 29
20 hsa-miR-621:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.213E-3 2.520E-2
1.585E-1
6.683E-1
 1 32
21 hsa-miR-518d-3p:PITA hsa-miR-518d-3p:PITA TOP PITA 2.835E-3 2.520E-2
1.585E-1
8.560E-1
 1 41
22 hsa-miR-518c:PITA hsa-miR-518c:PITA TOP PITA 2.835E-3 2.520E-2
1.585E-1
8.560E-1
 1 41
23 hsa-miR-518a-3p:PITA hsa-miR-518a-3p:PITA TOP PITA 2.835E-3 2.520E-2
1.585E-1
8.560E-1
 1 41
24 hsa-miR-518b:PITA hsa-miR-518b:PITA TOP PITA 2.835E-3 2.520E-2
1.585E-1
8.560E-1
 1 41
25 hsa-miR-518f:PITA hsa-miR-518f:PITA TOP PITA 2.835E-3 2.520E-2
1.585E-1
8.560E-1
 1 41
26 hsa-miR-4634:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.904E-3 2.520E-2
1.585E-1
8.769E-1
 1 42
27 hsa-miR-618:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.111E-3 2.520E-2
1.585E-1
9.395E-1
 1 45
28 hsa-miR-7158-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.249E-3 2.520E-2
1.585E-1
9.812E-1
 1 47
29 hsa-miR-4640-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.318E-3 2.520E-2
1.585E-1
1.000E0
 1 48
30 hsa-miR-3912-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.663E-3 2.520E-2
1.585E-1
1.000E0
 1 53
31 hsa-miR-6838-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.732E-3 2.520E-2
1.585E-1
1.000E0
 1 54
32 hsa-miR-4466:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.801E-3 2.520E-2
1.585E-1
1.000E0
 1 55
33 hsa-miR-7112-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.801E-3 2.520E-2
1.585E-1
1.000E0
 1 55
34 ATAACCT,MIR-154:MSigDB ATAACCT,MIR-154:MSigDB MSigDB 3.870E-3 2.520E-2
1.585E-1
1.000E0
 1 56
35 hsa-miR-499b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.353E-3 2.520E-2
1.585E-1
1.000E0
 1 63
36 hsa-miR-4708-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.422E-3 2.520E-2
1.585E-1
1.000E0
 1 64
37 hsa-miR-499a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.629E-3 2.520E-2
1.585E-1
1.000E0
 1 67
38 hsa-miR-3656:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.698E-3 2.520E-2
1.585E-1
1.000E0
 1 68
39 hsa-miR-31-3p:Functional MTI Functional MTI miRTarbase 4.836E-3 2.520E-2
1.585E-1
1.000E0
 1 70
40 hsa-miR-675-5p:Functional MTI Functional MTI miRTarbase 4.836E-3 2.520E-2
1.585E-1
1.000E0
 1 70
41 hsa-miR-3607-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.974E-3 2.520E-2
1.585E-1
1.000E0
 1 72
42 hsa-miR-4721:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.974E-3 2.520E-2
1.585E-1
1.000E0
 1 72
43 hsa-miR-5100:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.974E-3 2.520E-2
1.585E-1
1.000E0
 1 72
44 hsa-miR-6796-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.111E-3 2.520E-2
1.585E-1
1.000E0
 1 74
45 hsa-miR-198:Functional MTI Functional MTI miRTarbase 5.111E-3 2.520E-2
1.585E-1
1.000E0
 1 74
46 hsa-miR-6812-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.111E-3 2.520E-2
1.585E-1
1.000E0
 1 74
47 hsa-miR-106b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.249E-3 2.520E-2
1.585E-1
1.000E0
 1 76
48 hsa-miR-151a-3p:TargetScan hsa-miR-151a-3p TargetScan 5.318E-3 2.520E-2
1.585E-1
1.000E0
 1 77
49 hsa-miR-3688-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.456E-3 2.520E-2
1.585E-1
1.000E0
 1 79
50 hsa-miR-1226-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.594E-3 2.520E-2
1.585E-1
1.000E0
 1 81
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 2343 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000016043 TBHQ Stitch 6.924E-9 1.622E-5 1.353E-4 1.622E-5 4 141
2 CID004369394 AR E Stitch 4.969E-8 5.822E-5 4.853E-4 1.164E-4 4 230
3 CID000016741 PEITC Stitch 4.773E-7 3.728E-4 3.107E-3 1.118E-3 3 84
4 CID000004973 heme b Stitch 6.936E-7 4.063E-4 3.387E-3 1.625E-3 4 444
5 ctd:C033342 perillaldehyde CTD 1.379E-6 6.463E-4 5.388E-3 3.232E-3 2 9
6 CID000000251 Biliverdin hydrochloride Stitch 3.154E-6 1.166E-3 9.725E-3 7.390E-3 3 157
7 ctd:D016650 Fluorescein-5-isothiocyanate CTD 3.485E-6 1.166E-3 9.725E-3 8.165E-3 2 14
8 ctd:C014464 3,4-dichloroaniline CTD 4.078E-6 1.194E-3 9.957E-3 9.555E-3 3 171
9 CID000007703 anethol Stitch 5.857E-6 1.462E-3 1.219E-2 1.372E-2 2 18
10 CID011954184 2-butyl-6-methoxyphenol Stitch 6.239E-6 1.462E-3 1.219E-2 1.462E-2 3 197
11 ctd:D010076 Oxazepam CTD 1.148E-5 2.286E-3 1.906E-2 2.689E-2 2 25
12 CID000081462 BT-B Stitch 1.171E-5 2.286E-3 1.906E-2 2.743E-2 3 243
13 ctd:C464660 obeticholic acid CTD 1.848E-5 3.330E-3 2.776E-2 4.329E-2 3 283
14 ctd:D020126 Brefeldin A CTD 2.274E-5 3.806E-3 3.173E-2
5.329E-2
 2 35
15 ctd:C020722 cinnamyl alcohol CTD 3.449E-5 5.388E-3 4.492E-2
8.082E-2
 2 43
16 ctd:C004532 quinone CTD 5.259E-5 7.702E-3
6.421E-2
1.232E-1
 2 53
17 CID000435143 NSC-364372 Stitch 9.161E-5 1.179E-2
9.832E-2
2.146E-1
 3 484
18 CID003038361 DMEs Stitch 9.469E-5 1.179E-2
9.832E-2
2.219E-1
 2 71
19 ctd:C020300 monomethylarsonic acid CTD 9.739E-5 1.179E-2
9.832E-2
2.282E-1
 2 72
20 ctd:D012436 S-Adenosylmethionine CTD 1.057E-4 1.179E-2
9.832E-2
2.477E-1
 2 75
21 ctd:D004139 Dinitrofluorobenzene CTD 1.057E-4 1.179E-2
9.832E-2
2.477E-1
 2 75
22 CID000104913 DCFH-DA Stitch 1.391E-4 1.481E-2
1.235E-1
3.259E-1
 2 86
23 CID000123094 1,3-benzodithiole-2-thione Stitch 2.189E-4 1.583E-2
1.319E-1
5.129E-1
 1 1
24 ctd:D011420 Propiolactone CTD 2.189E-4 1.583E-2
1.319E-1
5.129E-1
 1 1
25 ctd:C497968 phenylglycidol CTD 2.189E-4 1.583E-2
1.319E-1
5.129E-1
 1 1
26 ctd:C011688 1-bromo-2,4-dinitrobenzene CTD 2.189E-4 1.583E-2
1.319E-1
5.129E-1
 1 1
27 ctd:C535072 pallidol CTD 2.189E-4 1.583E-2
1.319E-1
5.129E-1
 1 1
28 ctd:C045354 ochratoxin B CTD 2.189E-4 1.583E-2
1.319E-1
5.129E-1
 1 1
29 ctd:C043180 ethyl 3-phenylglycidate CTD 2.189E-4 1.583E-2
1.319E-1
5.129E-1
 1 1
30 ctd:D006873 Hydroquinones CTD 2.189E-4 1.583E-2
1.319E-1
5.129E-1
 1 1
31 ctd:C464945 bisindolylmaleimide VIII CTD 2.189E-4 1.583E-2
1.319E-1
5.129E-1
 1 1
32 CID000082146 bexarotene Stitch 2.318E-4 1.583E-2
1.319E-1
5.432E-1
 2 111
33 ctd:C018855 2-tert-butylhydroquinone CTD 2.402E-4 1.583E-2
1.319E-1
5.629E-1
 2 113
34 ctd:C472829 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole CTD 2.488E-4 1.583E-2
1.319E-1
5.830E-1
 2 115
35 ctd:D002083 Butylated Hydroxyanisole CTD 2.754E-4 1.583E-2
1.319E-1
6.454E-1
 2 121
36 CID000012201 AC1L1Z2L Stitch 2.846E-4 1.583E-2
1.319E-1
6.668E-1
 2 123
37 ctd:D002793 Cholic Acids CTD 3.034E-4 1.583E-2
1.319E-1
7.108E-1
 2 127
38 CID000007847 acrolein Stitch 3.478E-4 1.583E-2
1.319E-1
8.149E-1
 2 136
39 ctd:C553587 tubastatin A CTD 4.378E-4 1.583E-2
1.319E-1
1.000E0
 1 2
40 ctd:C016050 phenylglycidyl ether CTD 4.378E-4 1.583E-2
1.319E-1
1.000E0
 1 2
41 CID000124405 AC1L3YDV Stitch 4.378E-4 1.583E-2
1.319E-1
1.000E0
 1 2
42 ctd:C019359 2,5-di-tert-butylhydroquinone CTD 4.378E-4 1.583E-2
1.319E-1
1.000E0
 1 2
43 ctd:C009999 benzonidazole CTD 4.378E-4 1.583E-2
1.319E-1
1.000E0
 1 2
44 ctd:C098340 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose CTD 4.378E-4 1.583E-2
1.319E-1
1.000E0
 1 2
45 CID010199993 UCM707 Stitch 4.378E-4 1.583E-2
1.319E-1
1.000E0
 1 2
46 ctd:C034379 falcarindiol CTD 4.378E-4 1.583E-2
1.319E-1
1.000E0
 1 2
47 ctd:C052082 methyl gallate CTD 4.378E-4 1.583E-2
1.319E-1
1.000E0
 1 2
48 ctd:C037341 sodium selenide CTD 4.378E-4 1.583E-2
1.319E-1
1.000E0
 1 2
49 ctd:C063002 2,3-dimethoxy-1,4-naphthoquinone CTD 4.399E-4 1.583E-2
1.319E-1
1.000E0
 2 153
50 1010 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 4.573E-4 1.583E-2
1.319E-1
1.000E0
 2 156
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 285 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0271160 Cortical cataract DisGeNET Curated 7.985E-6 2.276E-3 1.418E-2 2.276E-3 2 15
2 C0016719 Friedreich Ataxia DisGeNET Curated 9.275E-5 1.256E-2
7.828E-2
 2.643E-2 2 50
3 C1832812 Cataracts, Congenital, with Sensorineural Deafness, Down Syndrome-Like Facial Appearance, Short Stature, and Mental Retardation DisGeNET Curated 3.085E-4 1.256E-2
7.828E-2
8.794E-2
 1 1
4 C3888097 CATARACT 21, MULTIPLE TYPES DisGeNET Curated 3.085E-4 1.256E-2
7.828E-2
8.794E-2
 1 1
5 cv:C1857768 Cataract, pulverulent, juvenile-onset Clinical Variations 3.085E-4 1.256E-2
7.828E-2
8.794E-2
 1 1
6 OMIN:610202 CATARACT, PULVERULENT, JUVENILE-ONSET OMIM 3.085E-4 1.256E-2
7.828E-2
8.794E-2
 1 1
7 C1857768 Cataract, Pulverulent, Juvenile-Onset DisGeNET Curated 3.085E-4 1.256E-2
7.828E-2
8.794E-2
 1 1
8 C4021568 Cortical pulverulent cataract DisGeNET Curated 6.170E-4 1.954E-2
1.218E-1
1.758E-1
 1 2
9 C0857862 Staphylococcus Aureus Pneumonia DisGeNET BeFree 6.170E-4 1.954E-2
1.218E-1
1.758E-1
 1 2
10 C1854111 Broad philtrum DisGeNET Curated 1.234E-3 2.705E-2
1.685E-1
3.516E-1
 1 4
11 C1336840 Type 2 Papillary Renal Cell Carcinoma DisGeNET BeFree 1.234E-3 2.705E-2
1.685E-1
3.516E-1
 1 4
12 C0521858 Decreased drug resistance DisGeNET BeFree 1.234E-3 2.705E-2
1.685E-1
3.516E-1
 1 4
13 C1856121 Broad eyebrows DisGeNET Curated 1.234E-3 2.705E-2
1.685E-1
3.516E-1
 1 4
14 20090303:Meyre Obesity GWAS 1.542E-3 2.930E-2
1.826E-1
4.395E-1
 1 5
15 C0149904 Cholestatic hepatitis DisGeNET BeFree 1.542E-3 2.930E-2
1.826E-1
4.395E-1
 1 5
16 C0034067 Pulmonary Emphysema DisGeNET Curated 1.834E-3 3.019E-2
1.881E-1
5.228E-1
 2 223
17 C0344523 Cataract, congenital, cerulean type 1 DisGeNET Curated 1.850E-3 3.019E-2
1.881E-1
5.273E-1
 1 6
18 C0266551 Congenital coloboma of iris DisGeNET Curated 2.158E-3 3.019E-2
1.881E-1
6.151E-1
 1 7
19 C0796160 MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE DisGeNET Curated 2.158E-3 3.019E-2
1.881E-1
6.151E-1
 1 7
20 C0014072 Experimental Autoimmune Encephalomyelitis DisGeNET Curated 2.158E-3 3.019E-2
1.881E-1
6.151E-1
 1 7
21 C0152020 Gastroparesis DisGeNET Curated 2.466E-3 3.019E-2
1.881E-1
7.029E-1
 1 8
22 C0748607 Recurrent seizures DisGeNET BeFree 2.466E-3 3.019E-2
1.881E-1
7.029E-1
 1 8
23 C1858854 MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS DisGeNET Curated 2.466E-3 3.019E-2
1.881E-1
7.029E-1
 1 8
24 C3274515 Severe Bronchopulmonary Dysplasia DisGeNET BeFree 2.774E-3 3.019E-2
1.881E-1
7.906E-1
 1 9
25 C1861829 Cataract microcornea syndrome DisGeNET Curated 3.082E-3 3.019E-2
1.881E-1
8.784E-1
 1 10
26 C0013990 Pathological accumulation of air in tissues DisGeNET Curated 3.082E-3 3.019E-2
1.881E-1
8.784E-1
 1 10
27 C0266525 Irido-corneal dysgenesis DisGeNET Curated 3.082E-3 3.019E-2
1.881E-1
8.784E-1
 1 10
28 C4045991 Perihilar Cholangiocarcinoma DisGeNET BeFree 3.082E-3 3.019E-2
1.881E-1
8.784E-1
 1 10
29 C0268483 Tyrosinemias DisGeNET Curated 3.082E-3 3.019E-2
1.881E-1
8.784E-1
 1 10
30 C1833118 Cataract, Pulverulent DisGeNET Curated 3.390E-3 3.019E-2
1.881E-1
9.661E-1
 1 11
31 C0238284 Acute mountain sickness DisGeNET BeFree 3.390E-3 3.019E-2
1.881E-1
9.661E-1
 1 11
32 C0858617 Posterior subcapsular cataract DisGeNET Curated 3.390E-3 3.019E-2
1.881E-1
9.661E-1
 1 11
33 C0036220 Kaposi Sarcoma DisGeNET Curated 3.806E-3 3.287E-2
2.048E-1
1.000E0
 2 323
34 C0242383 Age related macular degeneration DisGeNET Curated 4.113E-3 3.414E-2
2.128E-1
1.000E0
 2 336
35 C1335729 Refractory Neoplasm DisGeNET BeFree 4.313E-3 3.414E-2
2.128E-1
1.000E0
 1 14
36 C0458219 Complex Regional Pain Syndromes DisGeNET BeFree 4.313E-3 3.414E-2
2.128E-1
1.000E0
 1 14
37 C1321422 Monoblastic leukemia DisGeNET BeFree 4.620E-3 3.465E-2
2.159E-1
1.000E0
 1 15
38 C0236053 Mucosal ulcer DisGeNET BeFree 4.620E-3 3.465E-2
2.159E-1
1.000E0
 1 15
39 C0235272 Retinal damage DisGeNET BeFree 4.928E-3 3.601E-2
2.244E-1
1.000E0
 1 16
40 C0036508 Seborrheic dermatitis DisGeNET Curated 5.542E-3 3.741E-2
2.331E-1
1.000E0
 1 18
41 C0242488 Acute Lung Injury DisGeNET Curated 5.542E-3 3.741E-2
2.331E-1
1.000E0
 1 18
42 C0270726 Alexander Disease DisGeNET Curated 5.542E-3 3.741E-2
2.331E-1
1.000E0
 1 18
43 C0086543 Cataract DisGeNET Curated 5.645E-3 3.741E-2
2.331E-1
1.000E0
 2 395
44 C1860224 ABLEPHARON-MACROSTOMIA SYNDROME DisGeNET Curated 5.849E-3 3.789E-2
2.361E-1
1.000E0
 1 19
45 C0008372 Intrahepatic Cholestasis DisGeNET Curated 6.156E-3 3.814E-2
2.377E-1
1.000E0
 1 20
46 C0855173 Placental Choriocarcinoma DisGeNET BeFree 6.156E-3 3.814E-2
2.377E-1
1.000E0
 1 20
47 C1839163 THROMBOCYTOPENIA 1 (disorder) DisGeNET Curated 6.464E-3 3.838E-2
2.391E-1
1.000E0
 1 21
48 C1859598 ATAXIA, EARLY-ONSET, WITH OCULOMOTOR APRAXIA AND HYPOALBUMINEMIA DisGeNET Curated 6.464E-3 3.838E-2
2.391E-1
1.000E0
 1 21
49 C0234533 Generalized seizures DisGeNET Curated 6.770E-3 3.938E-2
2.454E-1
1.000E0
 1 22
50 C3899403 Decreased Concentration DisGeNET BeFree 7.384E-3 4.070E-2
2.536E-1
1.000E0
 1 24
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