Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc251_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 30 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004860 protein kinase inhibitor activity 1.316E-11 2.212E-10 8.837E-10 3.949E-10 5 89
2 GO:0019210 kinase inhibitor activity 1.475E-11 2.212E-10 8.837E-10 4.424E-10 5 91
3 GO:0019887 protein kinase regulator activity 7.043E-10 7.043E-9 2.814E-8 2.113E-8 5 195
4 GO:0019207 kinase regulator activity 1.179E-9 8.845E-9 3.533E-8 3.538E-8 5 216
5 GO:0004857 enzyme inhibitor activity 2.382E-8 1.429E-7 5.710E-7 7.147E-7 5 393
6 GO:0005159 insulin-like growth factor receptor binding 9.029E-6 4.515E-5 1.804E-4 2.709E-4 2 15
7 GO:0008269 JAK pathway signal transduction adaptor activity 6.430E-4 2.756E-3 1.101E-2 1.929E-2 1 2
8 GO:0005131 growth hormone receptor binding 1.928E-3 7.229E-3 2.888E-2
5.784E-2
 1 6
Show 3 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 151 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0046426 negative regulation of JAK-STAT cascade 5.496E-13 4.150E-11 2.323E-10 8.299E-11 5 48
2 GO:1904893 negative regulation of STAT cascade 5.496E-13 4.150E-11 2.323E-10 8.299E-11 5 48
3 GO:0008286 insulin receptor signaling pathway 7.812E-11 3.932E-9 2.201E-8 1.180E-8 5 126
4 GO:0046627 negative regulation of insulin receptor signaling pathway 1.759E-10 5.652E-9 3.164E-8 2.656E-8 4 36
5 GO:1900077 negative regulation of cellular response to insulin stimulus 2.455E-10 5.652E-9 3.164E-8 3.707E-8 4 39
6 GO:0046425 regulation of JAK-STAT cascade 2.620E-10 5.652E-9 3.164E-8 3.956E-8 5 160
7 GO:1904892 regulation of STAT cascade 2.620E-10 5.652E-9 3.164E-8 3.956E-8 5 160
8 GO:0007259 JAK-STAT cascade 6.077E-10 1.020E-8 5.707E-8 9.176E-8 5 189
9 GO:0097696 STAT cascade 6.077E-10 1.020E-8 5.707E-8 9.176E-8 5 189
10 GO:0046626 regulation of insulin receptor signaling pathway 8.072E-10 1.219E-8 6.823E-8 1.219E-7 4 52
11 GO:0032869 cellular response to insulin stimulus 9.850E-10 1.352E-8 7.569E-8 1.487E-7 5 208
12 GO:0006469 negative regulation of protein kinase activity 2.437E-9 3.066E-8 1.716E-7 3.680E-7 5 249
13 GO:1900076 regulation of cellular response to insulin stimulus 2.892E-9 3.360E-8 1.881E-7 4.367E-7 4 71
14 GO:0032868 response to insulin 3.396E-9 3.663E-8 2.051E-7 5.129E-7 5 266
15 GO:0033673 negative regulation of kinase activity 4.015E-9 4.041E-8 2.262E-7 6.062E-7 5 275
16 GO:0071375 cellular response to peptide hormone stimulus 9.144E-9 8.630E-8 4.831E-7 1.381E-6 5 324
17 GO:1901653 cellular response to peptide 1.164E-8 1.034E-7 5.790E-7 1.758E-6 5 340
18 GO:0051348 negative regulation of transferase activity 1.980E-8 1.661E-7 9.300E-7 2.990E-6 5 378
19 GO:0001933 negative regulation of protein phosphorylation 3.603E-8 2.864E-7 1.603E-6 5.441E-6 5 426
20 GO:0043434 response to peptide hormone 4.333E-8 3.272E-7 1.831E-6 6.543E-6 5 442
21 GO:0042326 negative regulation of phosphorylation 6.082E-8 4.354E-7 2.437E-6 9.184E-6 5 473
22 GO:1901652 response to peptide 6.343E-8 4.354E-7 2.437E-6 9.579E-6 5 477
23 GO:1902532 negative regulation of intracellular signal transduction 7.256E-8 4.764E-7 2.667E-6 1.096E-5 5 490
24 GO:0021942 radial glia guided migration of Purkinje cell 1.815E-6 1.142E-5 6.393E-5 2.741E-4 2 7
25 GO:0021932 hindbrain radial glia guided cell migration 6.737E-6 4.069E-5 2.278E-4 1.017E-3 2 13
26 GO:0032355 response to estradiol 1.047E-5 6.082E-5 3.404E-4 1.581E-3 3 152
27 GO:0021535 cell migration in hindbrain 1.174E-5 6.565E-5 3.675E-4 1.773E-3 2 17
28 GO:0060334 regulation of interferon-gamma-mediated signaling pathway 1.812E-5 9.770E-5 5.469E-4 2.736E-3 2 21
29 GO:0060330 regulation of response to interferon-gamma 1.993E-5 1.038E-4 5.808E-4 3.009E-3 2 22
30 GO:0043627 response to estrogen 3.809E-5 1.917E-4 1.073E-3 5.752E-3 3 234
31 GO:0021799 cerebral cortex radially oriented cell migration 4.831E-5 2.353E-4 1.317E-3 7.294E-3 2 34
32 GO:0032570 response to progesterone 1.052E-4 4.966E-4 2.780E-3 1.589E-2 2 50
33 GO:0021795 cerebral cortex cell migration 1.139E-4 5.211E-4 2.917E-3 1.720E-2 2 52
34 GO:0097305 response to alcohol 1.847E-4 8.202E-4 4.592E-3 2.789E-2 3 398
35 GO:0022029 telencephalon cell migration 1.952E-4 8.422E-4 4.714E-3 2.948E-2 2 68
36 GO:0021885 forebrain cell migration 2.129E-4 8.928E-4 4.998E-3 3.214E-2 2 71
37 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 2.504E-4 1.022E-3 5.721E-3 3.781E-2 2 77
38 GO:0007260 tyrosine phosphorylation of STAT protein 2.771E-4 1.101E-3 6.164E-3 4.185E-2 2 81
39 GO:0060333 interferon-gamma-mediated signaling pathway 3.052E-4 1.151E-3 6.440E-3 4.608E-2 2 85
40 GO:1904894 positive regulation of STAT cascade 3.124E-4 1.151E-3 6.440E-3 4.717E-2 2 86
41 GO:0046427 positive regulation of JAK-STAT cascade 3.124E-4 1.151E-3 6.440E-3 4.717E-2 2 86
42 GO:0031100 animal organ regeneration 3.421E-4 1.230E-3 6.885E-3
5.166E-2
 2 90
43 GO:0021987 cerebral cortex development 6.174E-4 2.168E-3 1.214E-2
9.323E-2
 2 121
44 GO:0071346 cellular response to interferon-gamma 8.252E-4 2.832E-3 1.585E-2
1.246E-1
 2 140
45 GO:0001959 regulation of cytokine-mediated signaling pathway 8.607E-4 2.888E-3 1.617E-2
1.300E-1
 2 143
46 GO:0060759 regulation of response to cytokine stimulus 9.339E-4 3.066E-3 1.716E-2
1.410E-1
 2 149
47 GO:0034341 response to interferon-gamma 1.116E-3 3.586E-3 2.007E-2
1.685E-1
 2 163
48 GO:0030902 hindbrain development 1.213E-3 3.816E-3 2.136E-2
1.832E-1
 2 170
49 GO:0021543 pallium development 1.285E-3 3.959E-3 2.216E-2
1.940E-1
 2 175
50 GO:0060708 spongiotrophoblast differentiation 1.610E-3 4.862E-3 2.722E-2
2.431E-1
 1 5
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 3 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031466 Cul5-RING ubiquitin ligase complex 1.887E-3 5.662E-3 1.038E-2 5.662E-3 1 6

4: Human Phenotype [Display Chart] 0 input genes in category / 0 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 6 input genes in category / 404 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008568 abnormal interleukin secretion 1.411E-6 5.701E-4 3.751E-3 5.701E-4 5 495
2 MP:0001860 liver inflammation 8.682E-5 1.754E-2
1.154E-1
 3.508E-2 3 172
3 MP:0000708 thymus hyperplasia 1.949E-4 2.520E-2
1.658E-1
7.874E-2
 2 38
4 MP:0008102 lymph node hyperplasia 2.618E-4 2.520E-2
1.658E-1
1.058E-1
 2 44
5 MP:0008577 increased circulating interferon-gamma level 3.119E-4 2.520E-2
1.658E-1
1.260E-1
 2 48
6 MP:0008551 abnormal circulating interferon-gamma level 8.883E-4 4.387E-2
2.887E-1
3.589E-1
 2 81
7 MP:0000709 enlarged thymus 1.071E-3 4.387E-2
2.887E-1
4.328E-1
 2 89
8 MP:0008076 abnormal CD4-positive T cell differentiation 1.194E-3 4.387E-2
2.887E-1
4.825E-1
 2 94
9 MP:0008650 abnormal interleukin-1 secretion 1.220E-3 4.387E-2
2.887E-1
4.928E-1
 2 95
10 MP:0000609 abnormal liver physiology 1.251E-3 4.387E-2
2.887E-1
5.056E-1
 3 425
11 MP:0002451 abnormal macrophage physiology 1.330E-3 4.387E-2
2.887E-1
5.374E-1
 3 434
12 MP:0002139 abnormal hepatobiliary system physiology 1.546E-3 4.387E-2
2.887E-1
6.245E-1
 3 457
13 MP:0008548 abnormal circulating interferon level 1.573E-3 4.387E-2
2.887E-1
6.355E-1
 2 108
14 MP:0004350 long humerus 1.737E-3 4.387E-2
2.887E-1
7.019E-1
 1 3
15 MP:0008951 long radius 1.737E-3 4.387E-2
2.887E-1
7.019E-1
 1 3
16 MP:0013771 decreased effector memory T-helper cell number 1.737E-3 4.387E-2
2.887E-1
7.019E-1
 1 3
17 MP:0008711 increased interleukin-9 secretion 2.316E-3 4.500E-2
2.961E-1
9.357E-1
 1 4
18 MP:0012100 absent spongiotrophoblast 2.316E-3 4.500E-2
2.961E-1
9.357E-1
 1 4
19 MP:0030885 increased radius size 2.316E-3 4.500E-2
2.961E-1
9.357E-1
 1 4
20 MP:0009716 abnormal subcommissural organ morphology 2.316E-3 4.500E-2
2.961E-1
9.357E-1
 1 4
21 MP:0008750 abnormal interferon level 2.339E-3 4.500E-2
2.961E-1
9.451E-1
 2 132
22 MP:0013760 abnormal T-helper cell morphology 2.739E-3 4.872E-2
3.206E-1
1.000E0
 2 143
23 MP:0010167 decreased response to stress-induced hyperthermia 2.894E-3 4.872E-2
3.206E-1
1.000E0
 1 5
24 MP:0013590 enlarged thymus medulla 2.894E-3 4.872E-2
3.206E-1
1.000E0
 1 5
Show 19 more annotations

6: Domain [Display Chart] 6 input genes in category / 28 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00253 SOCS SMART 4.836E-15 1.354E-13 5.317E-13 1.354E-13 5 20
2 PF07525 SOCS box Pfam 1.564E-13 1.005E-12 3.946E-12 4.380E-12 5 38
3 IPR001496 SOCS box InterPro 1.794E-13 1.005E-12 3.946E-12 5.024E-12 5 39
4 PS50225 SOCS PROSITE 1.794E-13 1.005E-12 3.946E-12 5.024E-12 5 39
5 SM00969 SOCS box SMART 1.794E-13 1.005E-12 3.946E-12 5.024E-12 5 39
6 PF00017 SH2 Pfam 2.462E-11 1.149E-10 4.511E-10 6.892E-10 5 101
7 SM00252 SH2 SMART 3.802E-11 1.167E-10 4.582E-10 1.065E-9 5 110
8 PS50001 SH2 PROSITE 3.981E-11 1.167E-10 4.582E-10 1.115E-9 5 111
9 3.30.505.10 - Gene3D 4.167E-11 1.167E-10 4.582E-10 1.167E-9 5 112
10 IPR000980 SH2 InterPro 4.167E-11 1.167E-10 4.582E-10 1.167E-9 5 112
11 IPR028410 SOCS2 InterPro 3.203E-4 5.978E-4 2.348E-3 8.967E-3 1 1
12 IPR028423 SOCS7 InterPro 3.203E-4 5.978E-4 2.348E-3 8.967E-3 1 1
13 IPR028414 SOCS3 InterPro 3.203E-4 5.978E-4 2.348E-3 8.967E-3 1 1
14 IPR028411 SOCS1 InterPro 3.203E-4 5.978E-4 2.348E-3 8.967E-3 1 1
15 IPR028425 CIS InterPro 3.203E-4 5.978E-4 2.348E-3 8.967E-3 1 1
16 SM00182 CULLIN SMART 2.240E-3 3.583E-3 1.407E-2
6.272E-2
 1 7
17 IPR016157 Cullin CS InterPro 2.240E-3 3.583E-3 1.407E-2
6.272E-2
 1 7
18 SM00884 Cullin Nedd8 SMART 2.560E-3 3.583E-3 1.407E-2
7.167E-2
 1 8
19 PF10557 Cullin Nedd8 Pfam 2.560E-3 3.583E-3 1.407E-2
7.167E-2
 1 8
20 IPR019559 Cullin neddylation domain InterPro 2.560E-3 3.583E-3 1.407E-2
7.167E-2
 1 8
21 IPR016158 Cullin homology InterPro 2.879E-3 3.583E-3 1.407E-2
8.062E-2
 1 9
22 IPR001373 Cullin N InterPro 3.199E-3 3.583E-3 1.407E-2
8.956E-2
 1 10
23 PF00888 Cullin Pfam 3.199E-3 3.583E-3 1.407E-2
8.956E-2
 1 10
24 PS01256 CULLIN 1 PROSITE 3.199E-3 3.583E-3 1.407E-2
8.956E-2
 1 10
25 PS50069 CULLIN 2 PROSITE 3.199E-3 3.583E-3 1.407E-2
8.956E-2
 1 10
26 IPR016159 Cullin repeat-like dom InterPro 3.837E-3 4.133E-3 1.623E-2
1.074E-1
 1 12
Show 21 more annotations

7: Pathway [Display Chart] 6 input genes in category / 70 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 814182 Prolactin signaling pathway BioSystems: KEGG 2.903E-11 2.032E-9 9.821E-9 2.032E-9 5 70
2 1269327 Growth hormone receptor signaling BioSystems: REACTOME 1.891E-10 6.619E-9 3.199E-8 1.324E-8 4 25
3 P00035 Interferon-gamma signaling pathway PantherDB 3.060E-10 7.140E-9 3.451E-8 2.142E-8 4 28
4 83077 Jak-STAT signaling pathway BioSystems: KEGG 1.721E-9 3.012E-8 1.455E-7 1.205E-7 5 156
5 137976 IL2-mediated signaling events BioSystems: Pathway Interaction Database 4.033E-9 5.647E-8 2.729E-7 2.823E-7 4 52
6 PW:0000143 insulin signaling Pathway Ontology 1.811E-7 2.113E-6 1.021E-5 1.268E-5 3 27
7 83094 Type II diabetes mellitus BioSystems: KEGG 9.368E-7 9.368E-6 4.528E-5 6.558E-5 3 46
8 1269315 Regulation of IFNG signaling BioSystems: REACTOME 1.757E-5 1.537E-4 7.429E-4 1.230E-3 2 14
9 83056 Ubiquitin mediated proteolysis BioSystems: KEGG 2.545E-5 1.821E-4 8.799E-4 1.781E-3 3 137
10 83090 Insulin signaling pathway BioSystems: KEGG 2.601E-5 1.821E-4 8.799E-4 1.821E-3 3 138
11 1269313 Regulation of IFNA signaling BioSystems: REACTOME 6.258E-5 3.983E-4 1.925E-3 4.381E-3 2 26
12 PW:0000209 JAK-STAT signaling Pathway Ontology 7.813E-5 4.558E-4 2.203E-3 5.469E-3 2 29
13 M8615 IL-2 Receptor Beta Chain in T cell Activation MSigDB C2 BIOCARTA (v6.0) 1.350E-4 7.271E-4 3.514E-3 9.452E-3 2 38
14 1269193 Antigen processing: Ubiquitination & Proteasome degradation BioSystems: REACTOME 3.004E-4 1.502E-3 7.258E-3 2.103E-2 3 314
15 137933 IL4-mediated signaling events BioSystems: Pathway Interaction Database 3.731E-4 1.741E-3 8.415E-3 2.612E-2 2 63
16 1269312 Interferon alpha/beta signaling BioSystems: REACTOME 4.476E-4 1.958E-3 9.464E-3 3.133E-2 2 69
17 1269192 Class I MHC mediated antigen processing & presentation BioSystems: REACTOME 5.107E-4 2.103E-3 1.016E-2 3.575E-2 3 376
18 1269314 Interferon gamma signaling BioSystems: REACTOME 8.295E-4 3.226E-3 1.559E-2
5.807E-2
 2 94
19 1470923 Interleukin-4 and 13 signaling BioSystems: REACTOME 1.217E-3 4.484E-3 2.167E-2
8.520E-2
 2 114
20 193147 Osteoclast differentiation BioSystems: KEGG 1.579E-3 5.527E-3 2.671E-2
1.105E-1
 2 130
21 1383027 PTK6 Activates STAT3 BioSystems: REACTOME 1.927E-3 6.422E-3 3.104E-2
1.349E-1
 1 4
22 1269311 Interferon Signaling BioSystems: REACTOME 3.764E-3 1.198E-2
5.788E-2
2.635E-1
 2 202
23 M5248 Jak-STAT Pathway MSigDB C2 BIOCARTA (v6.0) 4.330E-3 1.318E-2
6.369E-2
3.031E-1
 1 9
24 M4170 Interferon gamma pathway. MSigDB C2 BIOCARTA (v6.0) 4.811E-3 1.323E-2
6.392E-2
3.367E-1
 1 10
25 PW:0000435 neddylation Pathway Ontology 5.291E-3 1.323E-2
6.392E-2
3.703E-1
 1 11
26 M9174 STAT3 Pathway MSigDB C2 BIOCARTA (v6.0) 5.291E-3 1.323E-2
6.392E-2
3.703E-1
 1 11
27 1269325 Interleukin-6 signaling BioSystems: REACTOME 5.291E-3 1.323E-2
6.392E-2
3.703E-1
 1 11
28 PW:0000415 proteasome degradation involving cullin-dependent ubiquitin ligases Pathway Ontology 5.291E-3 1.323E-2
6.392E-2
3.703E-1
 1 11
29 PW:0000363 leptin system Pathway Ontology 5.770E-3 1.393E-2
6.731E-2
4.039E-1
 1 12
30 1269488 Regulation of KIT signaling BioSystems: REACTOME 7.688E-3 1.682E-2
8.127E-2
5.381E-1
 1 16
31 P00038 JAK/STAT signaling pathway PantherDB 7.688E-3 1.682E-2
8.127E-2
5.381E-1
 1 16
32 M8066 IL22 Soluble Receptor Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 7.688E-3 1.682E-2
8.127E-2
5.381E-1
 1 16
33 M9378 Interleukin 4 (IL-4) Pathway MSigDB C2 BIOCARTA (v6.0) 1.247E-2 2.589E-2
1.251E-1
8.727E-1
 1 26
34 1339142 Interleukin-6 family signaling BioSystems: REACTOME 1.294E-2 2.589E-2
1.251E-1
9.061E-1
 1 27
35 M1718 Genes related to IL4 rceptor signaling in B lymphocytes MSigDB C2 BIOCARTA (v6.0) 1.294E-2 2.589E-2
1.251E-1
9.061E-1
 1 27
36 M9043 Growth Hormone Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.342E-2 2.610E-2
1.261E-1
9.395E-1
 1 28
37 1457793 Downregulation of ERBB2 signaling BioSystems: REACTOME 1.437E-2 2.719E-2
1.314E-1
1.000E0
 1 30
38 138051 EPO signaling pathway BioSystems: Pathway Interaction Database 1.580E-2 2.911E-2
1.407E-1
1.000E0
 1 33
39 138000 IL23-mediated signaling events BioSystems: Pathway Interaction Database 1.770E-2 3.177E-2
1.536E-1
1.000E0
 1 37
40 138040 IFN-gamma pathway BioSystems: Pathway Interaction Database 1.913E-2 3.347E-2
1.618E-1
1.000E0
 1 40
41 137932 IL6-mediated signaling events BioSystems: Pathway Interaction Database 2.055E-2 3.508E-2
1.696E-1
1.000E0
 1 43
42 138017 Signaling events mediated by PTP1B BioSystems: Pathway Interaction Database 2.386E-2 3.946E-2
1.907E-1
1.000E0
 1 50
43 1269489 Signaling by ERBB2 BioSystems: REACTOME 2.433E-2 3.946E-2
1.907E-1
1.000E0
 1 51
44 138068 Signaling events mediated by Stem cell factor receptor (c-Kit) BioSystems: Pathway Interaction Database 2.480E-2 3.946E-2
1.907E-1
1.000E0
 1 52
45 138006 ATF-2 transcription factor network BioSystems: Pathway Interaction Database 2.622E-2 4.079E-2
1.971E-1
1.000E0
 1 55
46 1269098 Vif-mediated degradation of APOBEC3G BioSystems: REACTOME 2.716E-2 4.133E-2
1.998E-1
1.000E0
 1 57
47 137922 IL12-mediated signaling events BioSystems: Pathway Interaction Database 2.905E-2 4.326E-2
2.091E-1
1.000E0
 1 61
48 1383025 Signaling by PTK6 BioSystems: REACTOME 3.233E-2 4.686E-2
2.265E-1
1.000E0
 1 68
49 83093 Adipocytokine signaling pathway BioSystems: KEGG 3.280E-2 4.686E-2
2.265E-1
1.000E0
 1 69
Show 44 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 1572 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19385048 The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression. Pubmed 1.072E-22 1.685E-19 1.338E-18 1.685E-19 6 11
2 29361558 RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Pubmed 4.110E-20 3.230E-17 2.564E-16 6.461E-17 6 25
3 24210661 Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. Pubmed 6.869E-20 3.599E-17 2.857E-16 1.080E-16 6 27
4 9419338 Twenty proteins containing a C-terminal SOCS box form five structural classes. Pubmed 2.233E-18 8.776E-16 6.966E-15 3.510E-15 5 10
5 24131863 Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm. Pubmed 1.692E-16 3.800E-14 3.016E-13 2.660E-13 4 4
6 18820827 The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients. Pubmed 1.692E-16 3.800E-14 3.016E-13 2.660E-13 4 4
7 9844915 The CIS/JAB family: novel negative regulators of JAK signaling pathways. Pubmed 1.692E-16 3.800E-14 3.016E-13 2.660E-13 4 4
8 12396724 Differential roles of SOCS family members in EpoR signal transduction. Pubmed 8.460E-16 1.209E-13 9.597E-13 1.330E-12 4 5
9 21234523 Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase. Pubmed 8.460E-16 1.209E-13 9.597E-13 1.330E-12 4 5
10 10585430 SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. Pubmed 8.460E-16 1.209E-13 9.597E-13 1.330E-12 4 5
11 25286386 Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia. Pubmed 8.460E-16 1.209E-13 9.597E-13 1.330E-12 4 5
12 10867663 Expression of "suppressor of cytokine signalling" (SOCS) genes in the developing and adult mouse nervous system. Pubmed 2.538E-15 3.069E-13 2.436E-12 3.990E-12 4 6
13 10490101 SOCS3 is essential in the regulation of fetal liver erythropoiesis. Pubmed 2.538E-15 3.069E-13 2.436E-12 3.990E-12 4 6
14 9344848 Cloning and characterization of novel CIS family genes. Pubmed 5.922E-15 6.206E-13 4.926E-12 9.309E-12 4 7
15 10374907 Janus kinases and their role in growth and disease. Pubmed 5.922E-15 6.206E-13 4.926E-12 9.309E-12 4 7
16 12076535 The SOCS box: a tale of destruction and degradation. Pubmed 6.636E-15 6.520E-13 5.175E-12 1.043E-11 5 41
17 18508766 Elongin B/C recruitment regulates substrate binding by CIS. Pubmed 2.132E-14 1.971E-12 1.565E-11 3.351E-11 4 9
18 19595407 RSV replication is attenuated by counteracting expression of the suppressor of cytokine signaling (SOCS) molecules. Pubmed 2.154E-12 1.254E-10 9.955E-10 3.386E-9 3 3
19 17264307 Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling. Pubmed 2.154E-12 1.254E-10 9.955E-10 3.386E-9 3 3
20 28188673 Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy. Pubmed 2.154E-12 1.254E-10 9.955E-10 3.386E-9 3 3
21 9202125 A family of cytokine-inducible inhibitors of signalling. Pubmed 2.154E-12 1.254E-10 9.955E-10 3.386E-9 3 3
22 30453988 Suppressor of cytokine signaling (SOCS) genes are downregulated in breast cancer. Pubmed 2.154E-12 1.254E-10 9.955E-10 3.386E-9 3 3
23 20854017 Transcriptional upregulation of SOCS 1 and suppressors of cytokine signaling 3 mRNA in the absence of suppressors of cytokine signaling 2 mRNA after infection with West Nile virus or tick-borne encephalitis virus. Pubmed 2.154E-12 1.254E-10 9.955E-10 3.386E-9 3 3
24 28643757 Significance of expression of suppressor of cytokine signaling proteins: Suppressor of cytokine signaling-1, suppressor of cytokine signaling-2, and suppressor of cytokine signaling-3 in papillary thyroid cancer. Pubmed 2.154E-12 1.254E-10 9.955E-10 3.386E-9 3 3
25 15361843 Differential hypermethylation of SOCS genes in ovarian and breast carcinomas. Pubmed 2.154E-12 1.254E-10 9.955E-10 3.386E-9 3 3
26 11889171 Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor. Pubmed 2.154E-12 1.254E-10 9.955E-10 3.386E-9 3 3
27 9266833 Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Pubmed 2.154E-12 1.254E-10 9.955E-10 3.386E-9 3 3
28 27423467 Suppressor of cytokine signaling (SOCS) proteins are induced by IL-7 and target surface CD127 protein for degradation in human CD8 T cells. Pubmed 8.616E-12 4.369E-10 3.468E-9 1.354E-8 3 4
29 17974915 Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development. Pubmed 8.616E-12 4.369E-10 3.468E-9 1.354E-8 3 4
30 24966052 Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity. Pubmed 8.616E-12 4.369E-10 3.468E-9 1.354E-8 3 4
31 20433750 Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer. Pubmed 8.616E-12 4.369E-10 3.468E-9 1.354E-8 3 4
32 11713228 Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor. Pubmed 2.154E-11 1.026E-9 8.144E-9 3.386E-8 3 5
33 16684815 A complex interaction pattern of CIS and SOCS2 with the leptin receptor. Pubmed 2.154E-11 1.026E-9 8.144E-9 3.386E-8 3 5
34 9889194 Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. Pubmed 4.307E-11 1.992E-9 1.581E-8 6.771E-8 3 6
35 16961462 The C-terminus of CIS defines its interaction pattern. Pubmed 7.538E-11 3.291E-9 2.613E-8 1.185E-7 3 7
36 15240659 Cell proliferation and STAT6 pathways are negatively regulated in T cells by STAT1 and suppressors of cytokine signaling. Pubmed 7.538E-11 3.291E-9 2.613E-8 1.185E-7 3 7
37 25505247 Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2). Pubmed 4.736E-10 2.012E-8 1.597E-7 7.446E-7 3 12
38 23990909 Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1. Pubmed 6.157E-10 2.547E-8 2.022E-7 9.679E-7 3 13
39 15601820 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Pubmed 1.464E-9 5.899E-8 4.683E-7 2.301E-6 3 17
40 14694187 Are SOCS suppressors, regulators, and degraders? Pubmed 2.057E-8 3.139E-7 2.492E-6 3.233E-5 2 2
41 22213096 LNCaP prostate cancer cells with autocrine interleukin-6 expression are resistant to IL-6-induced neuroendocrine differentiation due to increased expression of suppressors of cytokine signaling. Pubmed 2.057E-8 3.139E-7 2.492E-6 3.233E-5 2 2
42 15491991 Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells. Pubmed 2.057E-8 3.139E-7 2.492E-6 3.233E-5 2 2
43 19919527 Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2. Pubmed 2.057E-8 3.139E-7 2.492E-6 3.233E-5 2 2
44 24275663 Leishmania donovani prevents oxidative burst-mediated apoptosis of host macrophages through selective induction of suppressors of cytokine signaling (SOCS) proteins. Pubmed 2.057E-8 3.139E-7 2.492E-6 3.233E-5 2 2
45 24140964 Japanese encephalitis virus infection modulates the expression of suppressors of cytokine signaling (SOCS) in macrophages: implications for the hosts' innate immune response. Pubmed 2.057E-8 3.139E-7 2.492E-6 3.233E-5 2 2
46 9826711 Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Pubmed 2.057E-8 3.139E-7 2.492E-6 3.233E-5 2 2
47 24595859 SOCS signaling in autoimmune diseases: molecular mechanisms and therapeutic implications. Pubmed 2.057E-8 3.139E-7 2.492E-6 3.233E-5 2 2
48 28182772 Murine cytomegalovirus infection of mouse macrophages stimulates early expression of suppressor of cytokine signaling (SOCS)1 and SOCS3. Pubmed 2.057E-8 3.139E-7 2.492E-6 3.233E-5 2 2
49 10534114 Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction. Pubmed 2.057E-8 3.139E-7 2.492E-6 3.233E-5 2 2
50 11034314 IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3. Pubmed 2.057E-8 3.139E-7 2.492E-6 3.233E-5 2 2
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 606 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:GHR GHR interactions 7.080E-13 4.291E-10 2.997E-9 4.291E-10 5 48
2 int:SOCS2 SOCS2 interactions 8.158E-12 2.472E-9 1.727E-8 4.944E-9 5 77
3 int:ELOB ELOB interactions 9.276E-11 1.874E-8 1.309E-7 5.621E-8 5 124
4 int:CUL5 CUL5 interactions 2.646E-10 3.261E-8 2.278E-7 1.604E-7 6 451
5 int:ELOC ELOC interactions 2.691E-10 3.261E-8 2.278E-7 1.631E-7 5 153
6 int:DAB1 DAB1 interactions 7.024E-9 7.094E-7 4.955E-6 4.256E-6 4 84
7 int:PRLR PRLR interactions 5.608E-8 4.248E-6 2.967E-5 3.399E-5 3 26
8 int:LCK LCK interactions 6.047E-8 4.248E-6 2.967E-5 3.665E-5 4 143
9 int:LEPR LEPR interactions 6.308E-8 4.248E-6 2.967E-5 3.823E-5 3 27
10 int:IL2RB IL2RB interactions 1.069E-7 6.478E-6 4.525E-5 6.478E-5 3 32
11 int:CISH CISH interactions 1.538E-7 8.474E-6 5.919E-5 9.321E-5 3 36
12 int:EPOR EPOR interactions 3.488E-7 1.762E-5 1.230E-4 2.114E-4 3 47
13 int:RNF7 RNF7 interactions 8.525E-7 3.974E-5 2.776E-4 5.166E-4 3 63
14 int:IRS2 IRS2 interactions 9.375E-7 4.058E-5 2.834E-4 5.681E-4 3 65
15 int:SOCS3 SOCS3 interactions 1.827E-6 7.184E-5 5.018E-4 1.107E-3 3 81
16 int:SOCS1 SOCS1 interactions 1.897E-6 7.184E-5 5.018E-4 1.149E-3 3 82
17 int:PTK2B PTK2B interactions 3.055E-6 1.089E-4 7.605E-4 1.851E-3 3 96
18 int:AMBRA1 AMBRA1 interactions 4.358E-6 1.467E-4 1.025E-3 2.641E-3 3 108
19 int:IL7R IL7R interactions 4.733E-6 1.510E-4 1.054E-3 2.868E-3 3 111
20 int:INSR INSR interactions 6.137E-6 1.859E-4 1.299E-3 3.719E-3 3 121
21 int:SOCS7 SOCS7 interactions 1.299E-5 3.627E-4 2.533E-3 7.872E-3 2 17
22 int:IGF1R IGF1R interactions 1.317E-5 3.627E-4 2.533E-3 7.979E-3 3 156
23 int:PTK2 PTK2 interactions 1.530E-5 4.030E-4 2.815E-3 9.270E-3 3 164
24 int:FLT3 FLT3 interactions 2.414E-5 5.852E-4 4.088E-3 1.463E-2 2 23
25 int:CSF3R CSF3R interactions 2.414E-5 5.852E-4 4.088E-3 1.463E-2 2 23
26 int:ABL1 ABL1 interactions 3.992E-5 9.303E-4 6.498E-3 2.419E-2 3 226
27 int:CSF2RB CSF2RB interactions 4.147E-5 9.307E-4 6.501E-3 2.513E-2 2 30
28 int:ERBB2 ERBB2 interactions 5.329E-5 1.153E-3 8.056E-3 3.230E-2 3 249
29 int:DCUN1D5 DCUN1D5 interactions 6.342E-5 1.325E-3 9.257E-3 3.843E-2 2 37
30 int:CSF1R CSF1R interactions 7.424E-5 1.500E-3 1.048E-2 4.499E-2 2 40
31 int:ETV6 ETV6 interactions 7.804E-5 1.526E-3 1.066E-2 4.729E-2 2 41
32 int:IRF7 IRF7 interactions 1.212E-4 2.294E-3 1.603E-2
7.342E-2
 2 51
33 int:CXCR4 CXCR4 interactions 1.410E-4 2.590E-3 1.809E-2
8.546E-2
 2 55
34 int:VHL VHL interactions 1.607E-4 2.851E-3 1.992E-2
9.737E-2
 3 361
35 int:TRAF6 TRAF6 interactions 1.647E-4 2.851E-3 1.992E-2
9.979E-2
 3 364
36 int:FGFR3 FGFR3 interactions 1.972E-4 3.320E-3 2.319E-2
1.195E-1
 2 65
37 int:ELOA ELOA interactions 2.096E-4 3.433E-3 2.398E-2
1.270E-1
 2 67
38 int:DIS3 DIS3 interactions 2.558E-4 3.974E-3 2.776E-2
1.550E-1
 2 74
39 int:CCNC CCNC interactions 2.558E-4 3.974E-3 2.776E-2
1.550E-1
 2 74
40 int:COMMD1 COMMD1 interactions 2.627E-4 3.981E-3 2.780E-2
1.592E-1
 2 75
41 int:KIT KIT interactions 2.698E-4 3.988E-3 2.785E-2
1.635E-1
 2 76
42 int:RASA1 RASA1 interactions 3.375E-4 4.784E-3 3.342E-2
2.045E-1
 2 85
43 int:CUL2 CUL2 interactions 3.395E-4 4.784E-3 3.342E-2
2.057E-1
 3 465
44 int:JAK3 JAK3 interactions 3.700E-4 5.096E-3 3.559E-2
2.242E-1
 2 89
45 int:COPS3 COPS3 interactions 4.763E-4 6.414E-3 4.480E-2
2.886E-1
 2 101
46 int:IRS1 IRS1 interactions 4.953E-4 6.525E-3 4.557E-2
3.001E-1
 2 103
47 int:MAP3K5 MAP3K5 interactions 5.344E-4 6.890E-3 4.812E-2
3.238E-1
 2 107
48 int:STAT5A STAT5A interactions 5.853E-4 7.389E-3
5.161E-2
3.547E-1
 2 112
49 int:NT5DC4 NT5DC4 interactions 6.778E-4 8.087E-3
5.649E-2
4.107E-1
 1 2
50 int:NWD2 NWD2 interactions 6.778E-4 8.087E-3
5.649E-2
4.107E-1
 1 2
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16p13.13 16p13.13 3.314E-3 1.438E-2 3.283E-2 1.657E-2 1 23
2 11q22.3 11q22.3 6.475E-3 1.438E-2 3.283E-2 3.237E-2 1 45
3 3p21.3 3p21.3 8.626E-3 1.438E-2 3.283E-2 4.313E-2 1 60
4 17q12 17q12 1.506E-2 1.577E-2 3.600E-2
7.528E-2
 1 105
5 17q25.3 17q25.3 1.577E-2 1.577E-2 3.600E-2
7.884E-2
 1 110

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 52 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$SREBP1 01 V$SREBP1 01 1.926E-3 3.365E-2
1.527E-1
1.002E-1
 2 138
2 V$ARNT 02 V$ARNT 02 3.771E-3 3.365E-2
1.527E-1
1.961E-1
 2 194
3 V$USF Q6 V$USF Q6 4.082E-3 3.365E-2
1.527E-1
2.123E-1
 2 202
4 V$STAT5B 01 V$STAT5B 01 4.082E-3 3.365E-2
1.527E-1
2.123E-1
 2 202
5 V$STAT5A 01 V$STAT5A 01 4.122E-3 3.365E-2
1.527E-1
2.144E-1
 2 203
6 V$HSF1 01 V$HSF1 01 4.447E-3 3.365E-2
1.527E-1
2.312E-1
 2 211
7 V$STAT 01 V$STAT 01 4.530E-3 3.365E-2
1.527E-1
2.356E-1
 2 213
8 TTCYNRGAA V$STAT5B 01 TTCYNRGAA V$STAT5B 01 6.994E-3 4.546E-2
2.063E-1
3.637E-1
 2 266
Show 3 more annotations

12: Gene Family [Display Chart] 6 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 764 SH2 domain containing|Suppressors of cytokine signaling genenames.org 2.023E-17 6.070E-17 1.113E-16 6.070E-17 5 8
2 741 SH2 domain containing genenames.org 2.850E-11 4.274E-11 7.836E-11 8.549E-11 5 101
3 1032 Cullins genenames.org 2.636E-3 2.636E-3 4.832E-3 7.907E-3 1 8

13: Coexpression [Display Chart] 6 input genes in category / 1209 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18480837-SuppTable2 Human Leukemia Puigdecanet08 48genes GeneSigDB 1.701E-10 2.057E-7 1.578E-6 2.057E-7 4 44
2 M6846 Genes down-regulated in macrophages: untreated versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 3.883E-8 1.357E-5 1.042E-4 4.695E-5 4 167
3 M7454 Genes down-regulated in CD4 [GeneID=920] T cells: STAT3 [GeneID=6774] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 7.546E-8 1.357E-5 1.042E-4 9.123E-5 4 197
4 M8710 Genes up-regulated in bone marrow-derived macrophages with MLL4 [GeneID=9757] knockout: control versus treated with LPS for 2h. MSigDB C7: Immunologic Signatures (v6.0) 7.546E-8 1.357E-5 1.042E-4 9.123E-5 4 197
5 M8714 Genes up-regulated in bone marrow-derived macrophages with MLL4 [GeneID=9757] knockout: control versus treated with LPS for 4h. MSigDB C7: Immunologic Signatures (v6.0) 7.546E-8 1.357E-5 1.042E-4 9.123E-5 4 197
6 M8739 Genes up-regulated in T cells: control versus IL2 [GeneID=3558] stimulation for 6h. MSigDB C7: Immunologic Signatures (v6.0) 7.701E-8 1.357E-5 1.042E-4 9.311E-5 4 198
7 M8737 Genes up-regulated in STAT5 double knock-in T cells: control versus IL2 [GeneID=3558] stimulation for 6h. MSigDB C7: Immunologic Signatures (v6.0) 7.859E-8 1.357E-5 1.042E-4 9.501E-5 4 199
8 M12676 Class NT (non-tolerizeable) genes: induced during the first LPS stimulation and induced at equal or greater degree in tolerant macrophages. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.404E-6 2.121E-4 1.628E-3 1.697E-3 4 409
9 17178894-Table1 Human Breast Fan06 104genes GeneSigDB 1.697E-6 2.280E-4 1.750E-3 2.052E-3 3 103
10 M13984 Genes up-regulated by IL2 [GeneID=3558] in cells derived from CD4+ [GeneID=920] cutaneous T-cell lymphoma (CTCL). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.367E-6 2.861E-4 2.196E-3 2.861E-3 3 115
11 M1990 Selected genes with immunologic function which were reciprocally changed in evasion and tolerogenic tumor models. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.093E-6 4.869E-4 3.737E-3 6.157E-3 2 14
12 M2526 Genes representing a co-expression network in atopic CD4 [GeneID=920] T lymphocyte responses. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.372E-6 4.869E-4 3.737E-3 6.495E-3 3 151
13 M8178 Genes down-regulated in HEK293 cells at 2h after stimulation by muramyl dipeptide [PubChem=11620162]: over-expressing wildtype NOD2 [GeneID=64127] versus control. MSigDB C7: Immunologic Signatures (v6.0) 9.104E-6 4.869E-4 3.737E-3 1.101E-2 3 180
14 M2819 Genes up-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 [Gene ID=3558] and then stimulated with IL15 [Gene ID=3600]. MSigDB C6: Oncogenic Signatures (v6.0) 1.071E-5 4.869E-4 3.737E-3 1.294E-2 3 190
15 M2822 Genes up-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 [Gene ID=3558] and then stimulated with IL2 [Gene ID=3558]. MSigDB C6: Oncogenic Signatures (v6.0) 1.088E-5 4.869E-4 3.737E-3 1.315E-2 3 191
16 M4208 Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 1 h versus the untreated cells at 1 h. MSigDB C7: Immunologic Signatures (v6.0) 1.175E-5 4.869E-4 3.737E-3 1.421E-2 3 196
17 M8708 Genes up-regulated in bone marrow-derived macrophages with heterozygous MLL4 [GeneID=9757] knockout: control versus treated with LPS for 2h. MSigDB C7: Immunologic Signatures (v6.0) 1.193E-5 4.869E-4 3.737E-3 1.443E-2 3 197
18 M7458 Genes down-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: medium versus IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 1.193E-5 4.869E-4 3.737E-3 1.443E-2 3 197
19 M8735 Genes down-regulated in T cells: control versus IL2 [GeneID=3558] stimulation for 17h. MSigDB C7: Immunologic Signatures (v6.0) 1.230E-5 4.869E-4 3.737E-3 1.487E-2 3 199
20 M3401 Genes down-regulated in comparison of control microglia cells versus those 1 h after stimulation with IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 1.230E-5 4.869E-4 3.737E-3 1.487E-2 3 199
21 M5273 Genes up-regulated in comparison of type 2 myeloid (T2M) cells treated with IL25 [GeneID=64806] versus macrophages treated with IL25 [GeneID=64806]. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 4.869E-4 3.737E-3 1.509E-2 3 200
22 M9028 Genes down-regulated in KLRG1- [GeneID=10219] T reg:SELL high CD69- [GeneID=6402;969] versus SELL low CD69+ [GeneID=6402;969]. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 4.869E-4 3.737E-3 1.509E-2 3 200
23 M9020 Genes down-regulated in lymphoid primed multipotent progenitors: wildtype versus LYL1 [GeneID=4066] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 4.869E-4 3.737E-3 1.509E-2 3 200
24 M3409 Genes up-regulated in comparison of microglia cells 1 h after stimulation with IFNG [GeneID=3458] versus microglia cells 6 h after the stimulation. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 4.869E-4 3.737E-3 1.509E-2 3 200
25 M9030 Genes up-regulated in KLRG1- SELL low [GeneID=10219;6402] T reg: CD69- [GeneID=969] versus CD69+ [GeneID=969]. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 4.869E-4 3.737E-3 1.509E-2 3 200
26 M9785 Genes down-regulated in resting CD8 T cells: wildtype versus MIR155 [GeneID=406947] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 4.869E-4 3.737E-3 1.509E-2 3 200
27 M5947 Genes up-regulated by STAT5 in response to IL2 stimulation. MSigDB H: Hallmark Gene Sets (v6.0) 1.248E-5 4.869E-4 3.737E-3 1.509E-2 3 200
28 M6928 Genes down-regulated in B lymphocytes: anti IgM versus CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 4.869E-4 3.737E-3 1.509E-2 3 200
29 M3676 Genes down-regulated in comparison of T effector cells from uninfected mice versus T effector cells from mice infected with S. mansoni. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 4.869E-4 3.737E-3 1.509E-2 3 200
30 M6892 Genes down-regulated in CD4 [GeneID=920] T cells with in vivo expansion: IL6 [GeneID=3569] versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 4.869E-4 3.737E-3 1.509E-2 3 200
31 M9749 Genes down-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: follicular helper (Tfh) versus Ly6c int CXCR5+ [GeneID=643]. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 4.869E-4 3.737E-3 1.509E-2 3 200
32 14583454-Table3 Human Brain Godard03 22genes GeneSigDB 1.292E-5 4.880E-4 3.745E-3 1.562E-2 2 22
33 18172295-Table3 Human Bone Heller08 43genes GeneSigDB 2.268E-5 8.310E-4 6.378E-3 2.742E-2 2 29
34 19074895-SuppTable4 Human Liver Sakai08 36genes GeneSigDB 3.132E-5 1.082E-3 8.305E-3 3.787E-2 2 34
35 16585964-SuppTable1 Mouse Lung not cancer Thimmulappa06 38genes GeneSigDB 3.132E-5 1.082E-3 8.305E-3 3.787E-2 2 34
36 M15473 Selected genes down-regulated in peripheral blood monocytes (PBMC) of patients with hepatocellular carcinoma (HCC) compared to those with chronic hepatitis. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.517E-5 1.181E-3 9.065E-3 4.252E-2 2 36
37 19351829-SuppTableA Human Lung Daniel09 314genes GeneSigDB 3.869E-5 1.264E-3 9.703E-3 4.677E-2 3 292
38 18722011-SuppTable2i Human Leukemia Sanchez-Guijo08 41genes GeneSigDB 4.135E-5 1.316E-3 1.010E-2 4.999E-2 2 39
39 M1978 Genes down-regulated in CD4+ [GeneID=920] T lymphocytes by expression of AML1 [GeneID=861] off a viral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.575E-5 1.383E-3 1.061E-2
5.531E-2
 2 41
40 18794132-Table1 Human Breast Shivapurkar08 43genes GeneSigDB 4.575E-5 1.383E-3 1.061E-2
5.531E-2
 2 41
41 11884566-Table4 Human Lymphoma Poole02 54genes GeneSigDB 6.288E-5 1.854E-3 1.423E-2
7.603E-2
 2 48
42 M19948 Genes whose DNA was methylated both in primary tumors and across a panel of cancer cell lines. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.577E-5 2.469E-3 1.895E-2
1.037E-1
 2 56
43 18277965-TableS1b Human Liver Skawran08 551genes GeneSigDB 1.181E-4 3.321E-3 2.549E-2
1.428E-1
 3 425
44 12631704-table1 Human StemCell Qi03 534genes GeneSigDB 1.663E-4 4.569E-3 3.507E-2
2.010E-1
 3 477
45 M5897 Genes up-regulated by IL6 [GeneID=3569] via STAT3 [GeneID=6774], e.g., during acute phase response. MSigDB H: Hallmark Gene Sets (v6.0) 2.076E-4 5.578E-3 4.281E-2
2.510E-1
 2 87
46 M10558 Genes up-regulated in peripheral B lymphocytes after incubation with IL4 [GeneID=3565] for 4 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.424E-4 6.370E-3 4.889E-2
2.930E-1
 2 94
47 12446012-Table2 Mouse Immune Carmody02 151genes GeneSigDB 3.440E-4 8.394E-3
6.443E-2
4.159E-1
 2 112
48 16479545-SuppTable1 Mouse Lung not cancer Kahnert06 163genes GeneSigDB 3.817E-4 8.394E-3
6.443E-2
4.615E-1
 2 118
49 M5888 Cluster 2: late ATM [GeneID=472] dependent genes induced by ionizing radiation treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.420E-4 8.394E-3
6.443E-2
5.344E-1
 2 127
50 18338247-SuppTable1 Human Breast Harvell08 183genes GeneSigDB 5.367E-4 8.394E-3
6.443E-2
6.489E-1
 2 140
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 688 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10X Human 8K PBMC CD4 T cells Subtype CD4 T cells-JUNB, CCR7, FHIT Top 200 Genes 10X Human 8K PBMC CD4 T cells Subtype CD4 T cells-JUNB, CCR7, FHIT Top 200 Genes 5.549E-5 1.239E-2
8.813E-2
 3.818E-2 3 311
2 10X Human 8K PBMC CD4 T cell Subtype CD4 T cell-LDHB LTB MALAT1 Top 200 Genes 10X Human 8K PBMC CD4 T cell Subtype CD4 T cell-LDHB LTB MALAT1 Top 200 Genes 6.862E-5 1.239E-2
8.813E-2
 4.721E-2 3 334
3 GSM399365 500 alpha beta T cells, T.4FP3+25+.Sp, 4+ 8- GFP+ 25+, Spleen, avg-3 Immgen.org, GSE15907 7.491E-5 1.239E-2
8.813E-2
5.154E-2
 3 344
4 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal B E18.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal B E18.5 Top 200 Genes 8.434E-5 1.239E-2
8.813E-2
5.802E-2
 3 358
5 10X Human 8K PBMC CD4 T cells (IL7R, CD3D, CD3E) Subtype CD4 T cells (IL7R, CD3D, CD3E)-T cell CD4 - B ITGB1-ANXA1-KLRB1 Top 200 Genes 10X Human 8K PBMC CD4 T cells (IL7R, CD3D, CD3E) Subtype CD4 T cells (IL7R, CD3D, CD3E)-T cell CD4 - B ITGB1-ANXA1-KLRB1 Top 200 Genes 9.006E-5 1.239E-2
8.813E-2
6.196E-2
 3 366
6 GSM605823 500 Myeloid Cells, DC.103-11b+.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 1.252E-4 1.436E-2
1.021E-1
8.615E-2
 3 409
7 GSM399365 100 alpha beta T cells, T.4FP3+25+.Sp, 4+ 8- GFP+ 25+, Spleen, avg-3 Immgen.org, GSE15907 1.640E-4 1.612E-2
1.147E-1
1.129E-1
 2 73
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour PapRCC R U/Kidney Tumour PapRCC R6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour PapRCC R U/Kidney Tumour PapRCC R6 Adult, Development, and Cancer types 2.495E-4 2.145E-2
1.526E-1
1.716E-1
 2 90
9 gudmap dev gonad e12.5 M SertoliCell Sox9 k1 1000 dev gonad e12.5 M SertoliCell Sox9 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 4.000E-4 3.058E-2
2.175E-1
2.752E-1
 2 114
10 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type B3/1/4 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type B3/1/4 TCGA-Thymus 5.521E-4 3.798E-2
2.701E-1
3.798E-1
 2 134
11 PCBC ratio iPSC method-OSK-l-N-p53KD vs ESC cfr-2X-p05 Pluripotent Stem Cells-reprogram OSK-l-N-p53KD vs Pluripotent Stem Cells-reprogram NA-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 6.459E-4 4.040E-2
2.873E-1
4.444E-1
 2 145
12 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Conventional Leiomyosarcoma/3/1 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Conventional Leiomyosarcoma/3/1 TCGA-Bone and Soft Tissue 8.250E-4 4.212E-2
2.995E-1
5.676E-1
 2 164
13 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma/Epitheliod/3/1 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma/Epitheliod/3/1 TCGA-Mesothelium 9.385E-4 4.212E-2
2.995E-1
6.457E-1
 2 175
14 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin/basal cell of epidermis Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin/basal cell of epidermis Tabula Muris Consortium 1.026E-3 4.212E-2
2.995E-1
7.056E-1
 2 183
15 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells static Subtype 7 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells static Subtype 7 Top 200 Genes StanfordMouse+HumanSingleCells 1.037E-3 4.212E-2
2.995E-1
7.132E-1
 2 184
16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal Wilms PT-U/Kidney Normal Wilms PT14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal Wilms PT-U/Kidney Normal Wilms PT14 Adult, Development, and Cancer types 1.037E-3 4.212E-2
2.995E-1
7.132E-1
 2 184
17 10X Human 8K PBMC CD4 T cell Overall Top 200 Genes 10X Human 8K PBMC CD4 T cell Overall Top 200 Genes 1.048E-3 4.212E-2
2.995E-1
7.209E-1
 2 185
18 Facebase ST1 e10.5 Nasal Pit 250 e10.5 Nasal Pit top-relative-expression-ranked 250 FaceBase_ST1 1.105E-3 4.212E-2
2.995E-1
7.601E-1
 2 190
19 gudmap developingKidney e14.5 whole kidney - Wnt4 KO 1000 k1 DevelopingKidney e14.5 whole kidney - Wnt4 KO emap-6674 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.163E-3 4.212E-2
2.995E-1
8.002E-1
 2 195
20 Facebase ST1 e10.5 MandibArch 500 1 e10.5 MandibArch top-relative-expression-ranked 500 1 FaceBase_ST1 1.347E-3 4.221E-2
3.002E-1
9.267E-1
 2 210
21 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - NOS/1/3 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - NOS/1/3 TCGA-Stomach 1.374E-3 4.221E-2
3.002E-1
9.451E-1
 1 5
22 gudmap developingLowerUrinaryTract e13.5 bladder mesenchyme 1000 k4 DevelopingLowerUrinaryTract e13.5 bladder mesenchyme emap-3087 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.398E-3 4.221E-2
3.002E-1
9.620E-1
 2 214
23 Lungmap Mouse Lung PND1 Endothelial Subtype Vascular Endothelial-E Lungmap Mouse Lung PND1 Endothelial Subtype Vascular Endothelial-E Lungmap CCHMC 1.411E-3 4.221E-2
3.002E-1
9.709E-1
 2 215
24 Lungmap Mouse Lung PND1 MyoFB Subtype MyoFB-C Lungmap Mouse Lung PND1 MyoFB Subtype MyoFB-C Lungmap CCHMC 1.812E-3 4.987E-2
3.546E-1
1.000E0
 2 244
25 Lungmap Mouse Lung PND1 MyoFB Subtype MyoFB-B Lungmap Mouse Lung PND1 MyoFB Subtype MyoFB-B Lungmap CCHMC 1.812E-3 4.987E-2
3.546E-1
1.000E0
 2 244
Show 20 more annotations

15: Computational [Display Chart] 6 input genes in category / 16 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M4172 MODULE 474 Genes in the cancer module 474. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.034E-5 6.455E-4 2.182E-3 6.455E-4 2 17
2 M18786 MODULE 248 Genes in the cancer module 248. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.377E-3 1.902E-2
6.429E-2
 3.803E-2 2 129

16: MicroRNA [Display Chart] 6 input genes in category / 355 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1302:PITA hsa-miR-1302:PITA TOP PITA 1.782E-7 6.327E-5 4.081E-4 6.327E-5 3 151
2 hsa-miR-578:PITA hsa-miR-578:PITA TOP PITA 1.992E-6 2.685E-4 1.732E-3 7.070E-4 3 337
3 hsa-miR-324-5p:mirSVR highEffct hsa-miR-324-5p:mirSVR conserved highEffect-0.5 MicroRNA.org 2.269E-6 2.685E-4 1.732E-3 8.056E-4 3 352
4 hsa-let-7f-5p:Functional MTI Functional MTI miRTarbase 3.254E-6 2.888E-4 1.863E-3 1.155E-3 3 397
5 hsa-miR-890:PITA hsa-miR-890:PITA TOP PITA 1.648E-4 8.064E-3
5.202E-2
5.850E-2
 2 241
6 hsa-miR-659:PITA hsa-miR-659:PITA TOP PITA 1.759E-4 8.064E-3
5.202E-2
6.244E-2
 2 249
7 hsa-miR-4779:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.335E-4 8.064E-3
5.202E-2
8.288E-2
 2 287
8 hsa-miR-4458:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.757E-4 8.064E-3
5.202E-2
9.788E-2
 2 312
9 hsa-miR-4500:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.757E-4 8.064E-3
5.202E-2
9.788E-2
 2 312
10 hsa-let-7i-5p:Functional MTI Functional MTI miRTarbase 3.158E-4 8.064E-3
5.202E-2
1.121E-1
 2 334
11 hsa-let-7g-5p:Functional MTI Functional MTI miRTarbase 3.291E-4 8.064E-3
5.202E-2
1.168E-1
 2 341
12 hsa-miR-30e-5p:Functional MTI Functional MTI miRTarbase 3.407E-4 8.064E-3
5.202E-2
1.210E-1
 2 347
13 hsa-miR-517a:mirSVR lowEffct hsa-miR-517a:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.545E-4 8.064E-3
5.202E-2
1.259E-1
 2 354
14 hsa-miR-30d-5p:Functional MTI Functional MTI miRTarbase 3.830E-4 8.064E-3
5.202E-2
1.360E-1
 2 368
15 hsa-miR-221-3p:Functional MTI Functional MTI miRTarbase 3.830E-4 8.064E-3
5.202E-2
1.360E-1
 2 368
16 AAGCACA,MIR-218:MSigDB AAGCACA,MIR-218:MSigDB MSigDB 3.871E-4 8.064E-3
5.202E-2
1.374E-1
 2 370
17 hsa-let-7d-5p:Functional MTI Functional MTI miRTarbase 4.387E-4 8.064E-3
5.202E-2
1.557E-1
 2 394
18 hsa-miR-517c:mirSVR lowEffct hsa-miR-517c:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 4.453E-4 8.064E-3
5.202E-2
1.581E-1
 2 397
19 hsa-miR-423-3p:mirSVR lowEffct hsa-miR-423-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 4.476E-4 8.064E-3
5.202E-2
1.589E-1
 2 398
20 hsa-miR-145:PITA hsa-miR-145:PITA TOP PITA 4.543E-4 8.064E-3
5.202E-2
1.613E-1
 2 401
21 hsa-miR-30b-5p:Functional MTI Functional MTI miRTarbase 4.887E-4 8.261E-3
5.329E-2
1.735E-1
 2 416
22 hsa-miR-371-3p:mirSVR lowEffct hsa-miR-371-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 5.712E-4 9.217E-3
5.946E-2
2.028E-1
 2 450
23 hsa-miR-182:PITA hsa-miR-182:PITA TOP PITA 6.466E-4 9.334E-3
6.021E-2
2.295E-1
 2 479
24 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 6.574E-4 9.334E-3
6.021E-2
2.334E-1
 2 483
25 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 6.574E-4 9.334E-3
6.021E-2
2.334E-1
 2 483
26 hsa-miR-6070:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.079E-3 1.474E-2
9.506E-2
3.831E-1
 1 13
27 hsa-miR-5091:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.577E-3 2.074E-2
1.338E-1
5.599E-1
 1 19
28 hsa-miR-572:Functional MTI Functional MTI miRTarbase 1.660E-3 2.105E-2
1.358E-1
5.893E-1
 1 20
29 hsa-miR-664b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.743E-3 2.134E-2
1.376E-1
6.187E-1
 1 21
30 hsa-miR-1181:mirSVR highEffct hsa-miR-1181:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.406E-3 2.724E-2
1.757E-1
8.542E-1
 1 29
31 hsa-miR-4738-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.406E-3 2.724E-2
1.757E-1
8.542E-1
 1 29
32 hsa-miR-4694-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.904E-3 2.724E-2
1.757E-1
1.000E0
 1 35
33 hsa-miR-6720-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.815E-3 2.724E-2
1.757E-1
1.000E0
 1 46
34 GGGATGC,MIR-324-5P:MSigDB GGGATGC,MIR-324-5P:MSigDB MSigDB 4.063E-3 2.724E-2
1.757E-1
1.000E0
 1 49
35 hsa-miR-1292-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 2.724E-2
1.757E-1
1.000E0
 1 50
36 hsa-miR-503-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 2.724E-2
1.757E-1
1.000E0
 1 50
37 hsa-miR-5580-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.228E-3 2.724E-2
1.757E-1
1.000E0
 1 51
38 hsa-miR-4684-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.311E-3 2.724E-2
1.757E-1
1.000E0
 1 52
39 hsa-miR-4765:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.394E-3 2.724E-2
1.757E-1
1.000E0
 1 53
40 hsa-miR-4489:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.394E-3 2.724E-2
1.757E-1
1.000E0
 1 53
41 GGCACAT,MIR-455:MSigDB GGCACAT,MIR-455:MSigDB MSigDB 4.560E-3 2.724E-2
1.757E-1
1.000E0
 1 55
42 hsa-miR-4473:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 2.724E-2
1.757E-1
1.000E0
 1 56
43 hsa-miR-4751:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.808E-3 2.724E-2
1.757E-1
1.000E0
 1 58
44 hsa-miR-508-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.890E-3 2.724E-2
1.757E-1
1.000E0
 1 59
45 hsa-miR-3074-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.890E-3 2.724E-2
1.757E-1
1.000E0
 1 59
46 hsa-miR-6815-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.056E-3 2.724E-2
1.757E-1
1.000E0
 1 61
47 hsa-miR-92b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.139E-3 2.724E-2
1.757E-1
1.000E0
 1 62
48 hsa-miR-4690-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.304E-3 2.724E-2
1.757E-1
1.000E0
 1 64
49 hsa-miR-6861-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.387E-3 2.724E-2
1.757E-1
1.000E0
 1 65
50 hsa-miR-671-3p:mirSVR highEffct hsa-miR-671-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.387E-3 2.724E-2
1.757E-1
1.000E0
 1 65
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 2654 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000078281 5-nitrothiophene-2-carboxaldehyde Stitch 1.007E-11 2.673E-8 2.262E-7 2.673E-8 3 3
2 CID000010351 3-furaldehyde Stitch 4.028E-11 5.345E-8 4.523E-7 1.069E-7 3 4
3 CID000007364 then aldehyde Stitch 1.007E-10 6.681E-8 5.653E-7 2.672E-7 3 5
4 CID000068135 3-thenaldehyde Stitch 1.007E-10 6.681E-8 5.653E-7 2.672E-7 3 5
5 CID004099798 AC1N47DH Stitch 8.455E-10 4.488E-7 3.797E-6 2.244E-6 3 9
6 CID000012774 5-nitro-2-furaldehyde Stitch 2.214E-9 9.792E-7 8.285E-6 5.875E-6 3 12
7 CID000446849 R,R-THC Stitch 2.878E-9 1.091E-6 9.231E-6 7.637E-6 3 13
8 ctd:D003513 Cycloheximide CTD 1.695E-8 5.624E-6 4.758E-5 4.499E-5 5 449
9 ctd:C545385 Mequindox CTD 5.479E-8 1.616E-5 1.367E-4 1.454E-4 3 33
10 ctd:D013469 Sulpiride CTD 1.070E-7 2.839E-5 2.402E-4 2.839E-4 3 41
11 CID000031277 TDGA Stitch 1.626E-7 3.923E-5 3.319E-4 4.315E-4 3 47
12 CID000100016 zebularine Stitch 2.087E-7 4.617E-5 3.906E-4 5.540E-4 3 51
13 CID006474725 cis isomer Stitch 3.091E-7 6.310E-5 5.339E-4 8.203E-4 3 58
14 CID000008126 oct-2-ene Stitch 1.609E-6 2.854E-4 2.415E-3 4.270E-3 2 8
15 CID000005519 TPEN Stitch 1.613E-6 2.854E-4 2.415E-3 4.281E-3 3 100
16 CID000125207 11-dodecenoic acid Stitch 2.069E-6 3.431E-4 2.903E-3 5.490E-3 2 9
17 ctd:C007262 deoxynivalenol CTD 2.864E-6 4.472E-4 3.784E-3 7.602E-3 4 483
18 CID000495963 NSC674718 Stitch 3.159E-6 4.658E-4 3.942E-3 8.385E-3 2 11
19 CID000003934 15-epi-lipoxin A4 Stitch 3.396E-6 4.744E-4 4.014E-3 9.013E-3 3 128
20 CID000010352 norbornene Stitch 4.480E-6 5.945E-4 5.030E-3 1.189E-2 2 13
21 CID000006360 isobutane Stitch 8.782E-6 1.110E-3 9.391E-3 2.331E-2 2 18
22 ctd:D006581 Hexachlorobenzene CTD 1.061E-5 1.280E-3 1.083E-2 2.815E-2 3 187
23 3165 DN Retinoic acid [302-79-4]; Down 200; 13.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.240E-5 1.431E-3 1.211E-2 3.291E-2 3 197
24 CID000007844 butylene Stitch 1.325E-5 1.466E-3 1.240E-2 3.517E-2 2 22
25 CID000019499 C4:1n-2 Stitch 2.167E-5 2.301E-3 1.947E-2
5.752E-2
 2 28
26 ctd:C517409 stattic CTD 2.665E-5 2.720E-3 2.302E-2
7.073E-2
 2 31
27 CID000007362 furfural Stitch 3.608E-5 3.547E-3 3.001E-2
9.577E-2
 2 36
28 CID000017166 AC1L29GH Stitch 4.243E-5 4.022E-3 3.403E-2
1.126E-1
 2 39
29 CID000444966 Cu L Stitch 4.694E-5 4.296E-3 3.635E-2
1.246E-1
 2 41
30 CID000123162 cyclopropyl Stitch 5.665E-5 4.866E-3 4.117E-2
1.503E-1
 2 45
31 CID000000338 salicylate Stitch 5.683E-5 4.866E-3 4.117E-2
1.508E-1
 3 328
32 CID003400930 AC1MOUJQ Stitch 5.921E-5 4.911E-3 4.155E-2
1.572E-1
 2 46
33 CID000006184 hexanal Stitch 6.184E-5 4.973E-3 4.208E-2
1.641E-1
 2 47
34 CID000138070 cyclopentyl Stitch 7.290E-5 5.528E-3 4.677E-2
1.935E-1
 2 51
35 CID000029320 MoO2 Stitch 7.290E-5 5.528E-3 4.677E-2
1.935E-1
 2 51
36 ctd:D004967 Estrogens CTD 7.684E-5 5.665E-3 4.793E-2
2.039E-1
 3 363
37 CID000014814 V2O5 Stitch 9.119E-5 6.541E-3
5.535E-2
2.420E-1
 2 57
38 CID000025476 Hypertensin II Stitch 1.262E-4 8.811E-3
7.456E-2
3.348E-1
 3 429
39 CID000057056 AC1L1M7Y Stitch 1.339E-4 9.109E-3
7.707E-2
3.553E-1
 2 69
40 CID011703683 CHEMBL372561 Stitch 1.499E-4 9.944E-3
8.414E-2
3.978E-1
 2 73
41 ctd:C082097 tocotrienol, delta CTD 1.625E-4 1.025E-2
8.675E-2
4.312E-1
 2 76
42 CID006437063 4-oxoretinoic acid Stitch 1.668E-4 1.025E-2
8.675E-2
4.427E-1
 2 77
43 ctd:C483161 beta-hydroxy simvastatin acid CTD 1.712E-4 1.025E-2
8.675E-2
4.543E-1
 2 78
44 CID000001491 2,4-dihydroxybenzoate Stitch 1.756E-4 1.025E-2
8.675E-2
4.660E-1
 2 79
45 CID000066393 estradiol-2,3-quinone Stitch 2.033E-4 1.025E-2
8.675E-2
5.396E-1
 2 85
46 CID000127712 Panamycin 607 Stitch 2.627E-4 1.025E-2
8.675E-2
6.972E-1
 1 1
47 CID000079488 4-isopropylcyclohexanone Stitch 2.627E-4 1.025E-2
8.675E-2
6.972E-1
 1 1
48 CID000069763 di-p-tolylcarbodiimide Stitch 2.627E-4 1.025E-2
8.675E-2
6.972E-1
 1 1
49 CID000097139 1,4-epoxy-1,4-dihydronaphthalene Stitch 2.627E-4 1.025E-2
8.675E-2
6.972E-1
 1 1
50 CID000188205 MFBL Stitch 2.627E-4 1.025E-2
8.675E-2
6.972E-1
 1 1
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 210 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0013884 Filarial Elephantiases DisGeNET BeFree 9.493E-12 1.994E-9 1.182E-8 1.994E-9 4 16
2 C0162820 Dermatitis, Allergic Contact DisGeNET Curated 1.947E-8 2.045E-6 1.212E-5 4.090E-6 4 99
3 C1292778 Chronic myeloproliferative disorder DisGeNET BeFree 6.322E-7 4.425E-5 2.623E-4 1.328E-4 4 235
4 C0333983 Hyperplastic Polyp DisGeNET BeFree 6.678E-6 3.356E-4 1.989E-3 1.402E-3 3 114
5 C1301034 Pancreatic intraepithelial neoplasia DisGeNET BeFree 7.990E-6 3.356E-4 1.989E-3 1.678E-3 3 121
6 C0040028 Thrombocythemia, Essential DisGeNET Curated 1.212E-5 4.242E-4 2.514E-3 2.545E-3 3 139
7 C0085083 Ovarian Hyperstimulation Syndrome DisGeNET Curated 5.287E-5 1.586E-3 9.401E-3 1.110E-2 2 31
8 C1332460 Barrett's Adenocarcinoma DisGeNET BeFree 7.157E-5 1.715E-3 1.016E-2 1.503E-2 2 36
9 C0027022 Myeloproliferative disease DisGeNET Curated 7.350E-5 1.715E-3 1.016E-2 1.544E-2 3 254
10 C1136033 Cutaneous Mastocytosis DisGeNET Curated 1.744E-4 3.567E-3 2.114E-2 3.662E-2 2 56
11 C0024301 Lymphoma, Follicular DisGeNET Curated 1.887E-4 3.567E-3 2.114E-2 3.964E-2 3 349
12 C0524910 Hepatitis C, Chronic DisGeNET Curated 2.190E-4 3.567E-3 2.114E-2 4.599E-2 3 367
13 C0042373 Vascular Diseases DisGeNET Curated 2.208E-4 3.567E-3 2.114E-2 4.637E-2 3 368
14 C1623038 Cirrhosis DisGeNET BeFree 2.783E-4 4.175E-3 2.474E-2
5.844E-2
 3 398
15 C0239946 Fibrosis, Liver DisGeNET Curated 3.593E-4 4.320E-3 2.560E-2
7.544E-2
 3 434
16 cv:C3280647 Bacteremia, susceptibility to, 2 Clinical Variations 3.703E-4 4.320E-3 2.560E-2
7.775E-2
 1 1
17 C0268733 Acute nephritis DisGeNET BeFree 3.703E-4 4.320E-3 2.560E-2
7.775E-2
 1 1
18 C1853963 DERMATITIS, ATOPIC, 4 DisGeNET Curated 3.703E-4 4.320E-3 2.560E-2
7.775E-2
 1 1
19 C0014378 Enterovirus Infections DisGeNET Curated 4.919E-4 5.436E-3 3.222E-2
1.033E-1
 2 94
20 C0042164 Uveitis DisGeNET Curated 5.676E-4 5.960E-3 3.532E-2
1.192E-1
 2 101
21 C0032131 Plasmacytoma DisGeNET Curated 6.974E-4 6.760E-3 4.007E-2
1.465E-1
 2 112
22 C0004712 Balo's Concentric Sclerosis DisGeNET BeFree 7.404E-4 6.760E-3 4.007E-2
1.555E-1
 1 2
23 C1334665 Mediastinal Lymphoma DisGeNET BeFree 7.404E-4 6.760E-3 4.007E-2
1.555E-1
 1 2
24 C1861453 Pseudohyperkalemia Cardiff DisGeNET Curated 9.095E-4 7.958E-3 4.717E-2
1.910E-1
 2 128
25 C0085605 Liver Failure DisGeNET Curated 1.262E-3 1.060E-2
6.285E-2
2.651E-1
 2 151
26 C0001815 Primary Myelofibrosis DisGeNET Curated 1.469E-3 1.142E-2
6.771E-2
3.085E-1
 2 163
27 C1333064 Classical Hodgkin's Lymphoma DisGeNET BeFree 1.469E-3 1.142E-2
6.771E-2
3.085E-1
 2 163
28 C0677898 invasive cancer DisGeNET BeFree 1.559E-3 1.170E-2
6.932E-2
3.275E-1
 2 168
29 C0021053 Immune System Diseases DisGeNET Curated 1.748E-3 1.266E-2
7.503E-2
3.671E-1
 2 178
30 C0041582 Ulcer DisGeNET Curated 1.927E-3 1.319E-2
7.819E-2
4.047E-1
 2 187
31 C0151650 Renal fibrosis DisGeNET BeFree 1.948E-3 1.319E-2
7.819E-2
4.090E-1
 2 188
32 C0032463 Polycythemia Vera DisGeNET Curated 2.136E-3 1.335E-2
7.910E-2
4.485E-1
 2 197
33 C3697010 Ulcerative colitis in remission DisGeNET BeFree 2.220E-3 1.335E-2
7.910E-2
4.662E-1
 1 6
34 C1266157 Intratubular malignant germ cells DisGeNET BeFree 2.220E-3 1.335E-2
7.910E-2
4.662E-1
 1 6
35 C1176475 Ductal Carcinoma DisGeNET Curated 2.244E-3 1.335E-2
7.910E-2
4.713E-1
 2 202
36 C0027430 Nasal Polyps DisGeNET Curated 2.288E-3 1.335E-2
7.910E-2
4.805E-1
 2 204
37 C0020615 Hypoglycemia DisGeNET Curated 2.423E-3 1.375E-2
8.149E-2
5.087E-1
 2 210
38 C1112157 Intrauterine infection DisGeNET BeFree 2.589E-3 1.431E-2
8.481E-2
5.438E-1
 1 7
39 C1334956 Neuroepithelial, Perineurial, and Schwann Cell Neoplasm DisGeNET BeFree 2.959E-3 1.516E-2
8.982E-2
6.214E-1
 1 8
40 C0023364 Leptospirosis DisGeNET BeFree 2.959E-3 1.516E-2
8.982E-2
6.214E-1
 1 8
41 C0020624 Hypomenorrhea DisGeNET BeFree 2.959E-3 1.516E-2
8.982E-2
6.214E-1
 1 8
42 C0333980 Focal Nodular Hyperplasia DisGeNET BeFree 3.328E-3 1.664E-2
9.863E-2
6.989E-1
 1 9
43 C0019159 Hepatitis A DisGeNET BeFree 3.659E-3 1.786E-2
1.059E-1
7.683E-1
 2 259
44 C0812413 Malignant Pleural Mesothelioma DisGeNET BeFree 3.742E-3 1.786E-2
1.059E-1
7.858E-1
 2 262
45 cv:C1834752 Mycobacterium tuberculosis, susceptibility to Clinical Variations 4.067E-3 1.817E-2
1.077E-1
8.540E-1
 1 11
46 C1834752 MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) DisGeNET Curated 4.067E-3 1.817E-2
1.077E-1
8.540E-1
 1 11
47 C0237967 pediatric AIDS DisGeNET BeFree 4.067E-3 1.817E-2
1.077E-1
8.540E-1
 1 11
48 C0032584 polyps DisGeNET Curated 4.203E-3 1.826E-2
1.082E-1
8.826E-1
 2 278
49 OMIN:607948 MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO OMIM 4.436E-3 1.826E-2
1.082E-1
9.315E-1
 1 12
50 C0157741 Idiopathic urticaria DisGeNET BeFree 4.436E-3 1.826E-2
1.082E-1
9.315E-1
 1 12
Show 45 more annotations