Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc252_16, positive side

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1: GO: Molecular Function [Display Chart] 15 input genes in category / 53 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001848 complement binding 4.766E-18 2.526E-16 1.151E-15 2.526E-16 7 21
2 GO:0004252 serine-type endopeptidase activity 1.636E-12 4.336E-11 1.976E-10 8.673E-11 8 215
3 GO:0008236 serine-type peptidase activity 4.240E-12 6.203E-11 2.827E-10 2.247E-10 8 242
4 GO:0017171 serine hydrolase activity 4.681E-12 6.203E-11 2.827E-10 2.481E-10 8 245
5 GO:0004175 endopeptidase activity 1.287E-11 1.365E-10 6.219E-10 6.823E-10 9 457
6 GO:0001846 opsonin binding 1.521E-7 1.344E-6 6.124E-6 8.063E-6 3 14
7 GO:0001855 complement component C4b binding 6.031E-7 4.566E-6 2.081E-5 3.196E-5 2 2
8 GO:0001851 complement component C3b binding 1.808E-6 1.198E-5 5.459E-5 9.584E-5 2 3
9 GO:0004875 complement receptor activity 3.615E-6 2.129E-5 9.701E-5 1.916E-4 2 4
10 GO:0048306 calcium-dependent protein binding 2.227E-5 1.120E-4 5.102E-4 1.180E-3 3 70
11 GO:0001618 virus receptor activity 2.324E-5 1.120E-4 5.102E-4 1.232E-3 3 71
12 GO:0004857 enzyme inhibitor activity 2.200E-4 9.715E-4 4.427E-3 1.166E-2 4 393
13 GO:0031715 C5L2 anaphylatoxin chemotactic receptor binding 8.038E-4 2.506E-3 1.142E-2 4.260E-2 1 1
14 GO:0004876 complement component C3a receptor activity 8.038E-4 2.506E-3 1.142E-2 4.260E-2 1 1
15 GO:0004877 complement component C3b receptor activity 8.038E-4 2.506E-3 1.142E-2 4.260E-2 1 1
16 GO:0031714 C5a anaphylatoxin chemotactic receptor binding 8.038E-4 2.506E-3 1.142E-2 4.260E-2 1 1
17 GO:0001861 complement component C4b receptor activity 8.038E-4 2.506E-3 1.142E-2 4.260E-2 1 1
18 GO:0001850 complement component C3a binding 1.607E-3 4.732E-3 2.156E-2
8.517E-2
 1 2
19 GO:0001847 opsonin receptor activity 3.212E-3 8.959E-3 4.082E-2
1.702E-1
 1 4
20 GO:0005534 galactose binding 5.614E-3 1.488E-2
6.779E-2
2.975E-1
 1 7
21 GO:0004866 endopeptidase inhibitor activity 8.105E-3 2.045E-2
9.321E-2
4.296E-1
 2 171
22 GO:0061135 endopeptidase regulator activity 8.661E-3 2.061E-2
9.394E-2
4.590E-1
 2 177
23 GO:0030414 peptidase inhibitor activity 8.946E-3 2.061E-2
9.394E-2
4.741E-1
 2 180
24 GO:0061134 peptidase regulator activity 1.336E-2 2.950E-2
1.344E-1
7.081E-1
 2 222
25 GO:0005537 mannose binding 1.517E-2 3.216E-2
1.465E-1
8.040E-1
 1 19
26 GO:0070273 phosphatidylinositol-4-phosphate binding 1.755E-2 3.577E-2
1.630E-1
9.299E-1
 1 22
27 GO:0043395 heparan sulfate proteoglycan binding 1.834E-2 3.599E-2
1.640E-1
9.718E-1
 1 23
28 GO:0004435 phosphatidylinositol phospholipase C activity 2.228E-2 4.217E-2
1.922E-1
1.000E0
 1 28
29 GO:0045296 cadherin binding 2.543E-2 4.647E-2
2.117E-1
1.000E0
 1 32
30 GO:0043394 proteoglycan binding 2.778E-2 4.907E-2
2.236E-1
1.000E0
 1 35
Show 25 more annotations

2: GO: Biological Process [Display Chart] 16 input genes in category / 388 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006956 complement activation 1.192E-38 4.624E-36 3.024E-35 4.624E-36 16 87
2 GO:0072376 protein activation cascade 9.574E-37 1.857E-34 1.215E-33 3.715E-34 16 112
3 GO:0006959 humoral immune response 1.037E-31 1.341E-29 8.767E-29 4.022E-29 16 223
4 GO:0030449 regulation of complement activation 2.745E-31 2.662E-29 1.741E-28 1.065E-28 12 34
5 GO:2000257 regulation of protein activation cascade 6.263E-31 4.860E-29 3.178E-28 2.430E-28 12 36
6 GO:0002920 regulation of humoral immune response 4.443E-28 2.873E-26 1.879E-25 1.724E-25 12 58
7 GO:0002673 regulation of acute inflammatory response 4.801E-26 2.661E-24 1.740E-23 1.863E-23 12 83
8 GO:0070613 regulation of protein processing 1.561E-25 7.573E-24 4.952E-23 6.059E-23 12 91
9 GO:1903317 regulation of protein maturation 1.795E-25 7.740E-24 5.062E-23 6.966E-23 12 92
10 GO:0002526 acute inflammatory response 4.257E-25 1.652E-23 1.080E-22 1.652E-22 13 159
11 GO:0006958 complement activation, classical pathway 1.138E-24 4.013E-23 2.624E-22 4.414E-22 11 63
12 GO:0002455 humoral immune response mediated by circulating immunoglobulin 1.928E-23 6.233E-22 4.076E-21 7.480E-21 11 80
13 GO:0016064 immunoglobulin mediated immune response 1.564E-20 4.668E-19 3.053E-18 6.069E-18 11 143
14 GO:0019724 B cell mediated immunity 1.980E-20 5.488E-19 3.589E-18 7.684E-18 11 146
15 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1.460E-19 3.778E-18 2.470E-17 5.667E-17 12 275
16 GO:0016485 protein processing 1.794E-18 4.351E-17 2.846E-16 6.962E-16 12 338
17 GO:0050727 regulation of inflammatory response 1.997E-18 4.559E-17 2.981E-16 7.750E-16 12 341
18 GO:0051604 protein maturation 4.708E-18 1.015E-16 6.637E-16 1.827E-15 12 366
19 GO:0002250 adaptive immune response 1.465E-17 2.991E-16 1.956E-15 5.684E-15 12 402
20 GO:0002449 lymphocyte mediated immunity 2.072E-17 4.020E-16 2.629E-15 8.039E-15 11 271
21 GO:0002697 regulation of immune effector process 8.711E-17 1.609E-15 1.053E-14 3.380E-14 12 466
22 GO:1903034 regulation of response to wounding 1.016E-16 1.792E-15 1.172E-14 3.943E-14 12 472
23 GO:0002443 leukocyte mediated immunity 4.285E-16 7.229E-15 4.728E-14 1.663E-13 11 356
24 GO:0045916 negative regulation of complement activation 1.078E-13 1.744E-12 1.140E-11 4.184E-11 5 11
25 GO:2000258 negative regulation of protein activation cascade 1.848E-13 2.868E-12 1.875E-11 7.170E-11 5 12
26 GO:0006957 complement activation, alternative pathway 6.996E-13 1.005E-11 6.575E-11 2.715E-10 5 15
27 GO:0002921 negative regulation of humoral immune response 6.996E-13 1.005E-11 6.575E-11 2.715E-10 5 15
28 GO:0001867 complement activation, lectin pathway 4.565E-11 6.326E-10 4.137E-9 1.771E-8 4 9
29 GO:0010955 negative regulation of protein processing 1.326E-10 1.714E-9 1.121E-8 5.143E-8 5 39
30 GO:1903318 negative regulation of protein maturation 1.326E-10 1.714E-9 1.121E-8 5.143E-8 5 39
31 GO:0002698 negative regulation of immune effector process 3.555E-8 4.450E-7 2.910E-6 1.379E-5 5 116
32 GO:0050777 negative regulation of immune response 9.133E-8 1.107E-6 7.242E-6 3.544E-5 5 140
33 GO:0045861 negative regulation of proteolysis 3.750E-7 4.410E-6 2.884E-5 1.455E-4 6 366
34 GO:0001970 positive regulation of activation of membrane attack complex 6.920E-7 7.897E-6 5.165E-5 2.685E-4 2 2
35 GO:0045917 positive regulation of complement activation 2.075E-6 2.119E-5 1.386E-4 8.051E-4 2 3
36 GO:0001969 regulation of activation of membrane attack complex 2.075E-6 2.119E-5 1.386E-4 8.051E-4 2 3
37 GO:2000259 positive regulation of protein activation cascade 2.075E-6 2.119E-5 1.386E-4 8.051E-4 2 3
38 GO:0001905 activation of membrane attack complex 2.075E-6 2.119E-5 1.386E-4 8.051E-4 2 3
39 GO:0002430 complement receptor mediated signaling pathway 6.910E-6 6.703E-5 4.383E-4 2.681E-3 2 5
40 GO:0030450 regulation of complement activation, classical pathway 6.910E-6 6.703E-5 4.383E-4 2.681E-3 2 5
41 GO:0002889 regulation of immunoglobulin mediated immune response 8.790E-6 8.120E-5 5.310E-4 3.410E-3 3 48
42 GO:0002712 regulation of B cell mediated immunity 8.790E-6 8.120E-5 5.310E-4 3.410E-3 3 48
43 GO:0050766 positive regulation of phagocytosis 1.643E-5 1.482E-4 9.692E-4 6.373E-3 3 59
44 GO:2000427 positive regulation of apoptotic cell clearance 1.932E-5 1.704E-4 1.114E-3 7.496E-3 2 8
45 GO:0002683 negative regulation of immune system process 2.027E-5 1.747E-4 1.143E-3 7.864E-3 5 420
46 GO:2000425 regulation of apoptotic cell clearance 3.789E-5 3.196E-4 2.090E-3 1.470E-2 2 11
47 GO:0050764 regulation of phagocytosis 5.098E-5 4.209E-4 2.752E-3 1.978E-2 3 86
48 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin 6.260E-5 5.060E-4 3.309E-3 2.429E-2 2 14
49 GO:0002922 positive regulation of humoral immune response 1.173E-4 9.291E-4 6.076E-3 4.553E-2 2 19
50 GO:0046718 viral entry into host cell 1.374E-4 1.024E-3 6.699E-3
5.332E-2
 3 120
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 16 input genes in category / 29 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0072562 blood microparticle 9.055E-8 2.626E-6 1.040E-5 2.626E-6 5 143
2 GO:0002079 inner acrosomal membrane 3.354E-3 4.863E-2
1.926E-1
9.726E-2
 1 4

4: Human Phenotype [Display Chart] 14 input genes in category / 489 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0005575 Hemolytic-uremic syndrome 1.684E-14 8.233E-12 5.574E-11 8.233E-12 7 19
2 HP:0001937 Microangiopathic hemolytic anemia 3.388E-13 8.283E-11 5.608E-10 1.657E-10 6 13
3 HP:0100519 Anuria 9.851E-13 1.606E-10 1.087E-9 4.817E-10 6 15
4 HP:0003138 Increased blood urea nitrogen 1.574E-12 1.924E-10 1.303E-9 7.697E-10 6 16
5 HP:0011037 Decreased urine output 4.459E-11 4.361E-9 2.953E-8 2.181E-8 6 26
6 HP:0004431 Complement deficiency 3.376E-10 2.751E-8 1.863E-7 1.651E-7 7 69
7 HP:0005416 Decreased serum complement factor B 1.706E-9 1.192E-7 8.071E-7 8.344E-7 4 7
8 HP:0005421 Decreased serum complement C3 3.407E-9 2.082E-7 1.410E-6 1.666E-6 4 8
9 HP:0005339 Abnormality of complement system 8.843E-9 4.805E-7 3.253E-6 4.324E-6 7 109
10 HP:0012590 Abnormal urine output 4.609E-8 2.254E-6 1.526E-5 2.254E-5 6 78
11 HP:0011036 Abnormality of renal excretion 8.337E-8 3.410E-6 2.309E-5 4.077E-5 6 86
12 HP:0005381 Recurrent meningococcal disease 8.367E-8 3.410E-6 2.309E-5 4.092E-5 3 4
13 HP:0003259 Elevated serum creatinine 3.285E-7 1.212E-5 8.208E-5 1.606E-4 6 108
14 HP:0012100 Abnormal circulating creatinine level 3.471E-7 1.212E-5 8.208E-5 1.697E-4 6 109
15 HP:0005430 Recurrent Neisserial infections 4.169E-7 1.274E-5 8.627E-5 2.039E-4 3 6
16 HP:0005369 Decreased serum complement factor H 4.169E-7 1.274E-5 8.627E-5 2.039E-4 3 6
17 HP:0011880 Acute disseminated intravascular coagulation 7.283E-7 2.095E-5 1.418E-4 3.561E-4 3 7
18 HP:0005356 Decreased serum complement factor I 1.742E-6 4.732E-5 3.204E-4 8.517E-4 3 9
19 HP:0001919 Acute kidney injury 1.966E-6 5.061E-5 3.427E-4 9.616E-4 6 146
20 HP:0008071 Maternal hypertension 3.409E-6 8.048E-5 5.449E-4 1.667E-3 3 11
21 HP:0005368 Abnormality of humoral immunity 3.471E-6 8.048E-5 5.449E-4 1.697E-3 8 383
22 HP:0000979 Purpura 3.621E-6 8.048E-5 5.449E-4 1.770E-3 6 162
23 HP:0002846 Abnormal B cell morphology 3.907E-6 8.306E-5 5.624E-4 1.910E-3 8 389
24 HP:0005420 Recurrent gram-negative bacterial infections 4.538E-6 9.246E-5 6.260E-4 2.219E-3 3 12
25 HP:0001933 Subcutaneous hemorrhage 9.072E-6 1.775E-4 1.201E-3 4.436E-3 7 299
26 HP:0100602 Preeclampsia 1.390E-5 2.518E-4 1.705E-3 6.799E-3 3 17
27 HP:0011419 Placental abruption 1.390E-5 2.518E-4 1.705E-3 6.799E-3 3 17
28 HP:0002157 Azotemia 1.589E-5 2.736E-4 1.853E-3 7.771E-3 6 209
29 HP:0012614 Abnormal urine cytology 1.679E-5 2.736E-4 1.853E-3 8.209E-3 6 211
30 HP:0000790 Hematuria 1.679E-5 2.736E-4 1.853E-3 8.209E-3 6 211
31 HP:0004364 Abnormality of nitrogen compound homeostasis 1.772E-5 2.796E-4 1.893E-3 8.667E-3 6 213
32 HP:0005225 Intestinal edema 2.461E-5 3.760E-4 2.546E-3 1.203E-2 2 3
33 HP:0001878 Hemolytic anemia 2.893E-5 4.160E-4 2.817E-3 1.414E-2 6 232
34 HP:0011895 Anemia due to reduced life span of red cells 2.893E-5 4.160E-4 2.817E-3 1.414E-2 6 232
35 HP:0000123 Nephritis 4.426E-5 6.184E-4 4.187E-3 2.164E-2 5 147
36 HP:0007937 Reticular pigmentary degeneration 4.913E-5 6.674E-4 4.518E-3 2.402E-2 2 4
37 HP:0030057 Autoimmune antibody positivity 1.229E-4 1.624E-3 1.099E-2
6.008E-2
 4 93
38 HP:0003613 Antiphospholipid antibody positivity 2.246E-4 2.784E-3 1.885E-2
1.098E-1
 3 42
39 HP:0011106 Hypovolemia 2.246E-4 2.784E-3 1.885E-2
1.098E-1
 3 42
40 HP:0001981 Schistocytosis 2.277E-4 2.784E-3 1.885E-2
1.114E-1
 2 8
41 HP:0005521 Disseminated intravascular coagulation 2.411E-4 2.807E-3 1.900E-2
1.179E-1
 3 43
42 HP:0011104 Abnormality of blood volume homeostasis 2.411E-4 2.807E-3 1.900E-2
1.179E-1
 3 43
43 HP:0100767 Abnormality of the placenta 2.950E-4 3.354E-3 2.271E-2
1.442E-1
 3 46
44 HP:0000093 Proteinuria 3.099E-4 3.445E-3 2.332E-2
1.516E-1
 6 354
45 HP:0100601 Eclampsia 4.249E-4 4.617E-3 3.126E-2
2.078E-1
 3 52
46 HP:0000099 Glomerulonephritis 4.619E-4 4.910E-3 3.324E-2
2.258E-1
 4 131
47 HP:0002718 Recurrent bacterial infections 5.175E-4 5.384E-3 3.645E-2
2.531E-1
 5 247
48 HP:0002725 Systemic lupus erythematosus 5.633E-4 5.738E-3 3.885E-2
2.754E-1
 4 138
49 HP:0100603 Toxemia of pregnancy 6.811E-4 6.748E-3 4.569E-2
3.330E-1
 3 61
50 HP:0000091 Abnormality of the renal tubule 6.900E-4 6.748E-3 4.569E-2
3.374E-1
 6 410
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 12 input genes in category / 401 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002471 abnormal complement pathway 2.911E-14 1.167E-11 7.671E-11 1.167E-11 6 21
2 MP:0002472 impaired complement alternative pathway 4.151E-8 8.323E-6 5.470E-5 1.665E-5 3 7
3 MP:0002473 impaired complement classical pathway 1.229E-5 1.642E-3 1.080E-2 4.927E-3 2 5
4 MP:0020518 renal glomerular protein deposits 2.260E-5 2.192E-3 1.440E-2 9.064E-3 3 50
5 MP:0002827 abnormal renal corpuscle morphology 2.949E-5 2.192E-3 1.440E-2 1.182E-2 5 354
6 MP:0005166 decreased susceptibility to injury 3.279E-5 2.192E-3 1.440E-2 1.315E-2 4 172
7 MP:0000521 abnormal kidney cortex morphology 4.308E-5 2.468E-3 1.622E-2 1.728E-2 5 383
8 MP:0005239 abnormal Bruch membrane morphology 1.464E-4 7.339E-3 4.823E-2
5.871E-2
 2 16
9 MP:0005325 abnormal renal glomerulus morphology 3.907E-4 1.448E-2
9.519E-2
1.567E-1
 4 326
10 MP:0005517 decreased liver regeneration 3.940E-4 1.448E-2
9.519E-2
1.580E-1
 2 26
11 MP:0003884 decreased macrophage cell number 4.095E-4 1.448E-2
9.519E-2
1.642E-1
 3 132
12 MP:0002425 altered susceptibility to autoimmune disorder 4.334E-4 1.448E-2
9.519E-2
1.738E-1
 4 335
13 MP:0002658 abnormal liver regeneration 8.017E-4 2.461E-2
1.617E-1
3.215E-1
 2 37
14 MP:0001844 autoimmune response 1.010E-3 2.461E-2
1.617E-1
4.048E-1
 4 419
15 MP:0005005 abnormal self tolerance 1.028E-3 2.461E-2
1.617E-1
4.121E-1
 4 421
16 MP:0005000 abnormal immune tolerance 1.103E-3 2.461E-2
1.617E-1
4.422E-1
 4 429
17 MP:0004823 increased susceptibility to experimental autoimmune myasthenia gravis 1.159E-3 2.461E-2
1.617E-1
4.647E-1
 1 1
18 MP:0011557 increased susceptibility to induced choroid neovascularization 1.159E-3 2.461E-2
1.617E-1
4.647E-1
 1 1
19 MP:0006315 abnormal urine protein level 1.166E-3 2.461E-2
1.617E-1
4.676E-1
 3 189
20 MP:0005351 decreased susceptibility to autoimmune disorder 1.413E-3 2.833E-2
1.862E-1
5.666E-1
 3 202
21 MP:0002059 abnormal seminal vesicle morphology 1.624E-3 3.101E-2
2.038E-1
6.511E-1
 3 212
22 MP:0003329 amyloid beta deposits 1.704E-3 3.106E-2
2.041E-1
6.832E-1
 2 54
23 MP:0005098 abnormal optic choroid morphology 1.831E-3 3.193E-2
2.098E-1
7.343E-1
 2 56
24 MP:0011738 anasarca 2.316E-3 3.573E-2
2.348E-1
9.289E-1
 1 2
25 MP:0009062 impaired lectin complement pathway 2.316E-3 3.573E-2
2.348E-1
9.289E-1
 1 2
26 MP:0005615 increased susceptibility to type III hypersensitivity reaction 2.316E-3 3.573E-2
2.348E-1
9.289E-1
 1 2
27 MP:0004985 decreased osteoclast cell number 2.459E-3 3.652E-2
2.400E-1
9.861E-1
 2 65
28 MP:0003436 decreased susceptibility to induced arthritis 2.766E-3 3.723E-2
2.447E-1
1.000E0
 2 69
29 MP:0003079 decreased susceptibility to induced joint inflammation 2.766E-3 3.723E-2
2.447E-1
1.000E0
 2 69
30 MP:0000604 amyloidosis 2.846E-3 3.723E-2
2.447E-1
1.000E0
 2 70
31 MP:0013330 abnormal male accessory sex gland morphology 2.878E-3 3.723E-2
2.447E-1
1.000E0
 3 259
32 MP:0002412 increased susceptibility to bacterial infection 2.974E-3 3.727E-2
2.449E-1
1.000E0
 3 262
33 MP:0001619 abnormal vascular permeability 3.433E-3 4.001E-2
2.629E-1
1.000E0
 2 77
34 MP:0005540 decreased urine albumin level 3.473E-3 4.001E-2
2.629E-1
1.000E0
 1 3
35 MP:0014062 nervous system inclusion bodies 3.610E-3 4.001E-2
2.629E-1
1.000E0
 2 79
36 MP:0002551 abnormal blood coagulation 3.626E-3 4.001E-2
2.629E-1
1.000E0
 3 281
37 MP:0009676 abnormal hemostasis 3.700E-3 4.001E-2
2.629E-1
1.000E0
 3 283
38 MP:0002871 albuminuria 3.791E-3 4.001E-2
2.629E-1
1.000E0
 2 81
39 MP:0020202 abnormal macrophage cell number 3.925E-3 4.036E-2
2.653E-1
1.000E0
 3 289
40 MP:0011898 abnormal platelet cell number 4.280E-3 4.290E-2
2.820E-1
1.000E0
 3 298
41 MP:0010215 abnormal circulating complement protein level 4.628E-3 4.316E-2
2.837E-1
1.000E0
 1 4
42 MP:0013807 generalized edema 4.628E-3 4.316E-2
2.837E-1
1.000E0
 1 4
43 MP:0004828 decreased susceptibility to autoimmune hemolytic anemia 4.628E-3 4.316E-2
2.837E-1
1.000E0
 1 4
Show 38 more annotations

6: Domain [Display Chart] 16 input genes in category / 126 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00084 Sushi Pfam 1.048E-25 1.007E-23 5.454E-23 1.320E-23 11 52
2 SM00032 CCP SMART 1.659E-25 1.007E-23 5.454E-23 2.091E-23 11 54
3 PS50923 SUSHI PROSITE 2.580E-25 1.007E-23 5.454E-23 3.251E-23 11 56
4 IPR000436 Sushi SCR CCP dom InterPro 3.196E-25 1.007E-23 5.454E-23 4.027E-23 11 57
5 IPR033116 TRYPSIN SER InterPro 7.994E-11 2.015E-9 1.091E-8 1.007E-8 6 90
6 IPR018114 TRYPSIN HIS InterPro 1.825E-10 3.626E-9 1.965E-8 2.299E-8 6 103
7 PS00135 TRYPSIN SER PROSITE 2.174E-10 3.626E-9 1.965E-8 2.740E-8 6 106
8 PS00134 TRYPSIN HIS PROSITE 2.302E-10 3.626E-9 1.965E-8 2.901E-8 6 107
9 IPR001314 Peptidase S1A InterPro 3.210E-10 4.494E-9 2.435E-8 4.045E-8 6 113
10 PS50240 TRYPSIN DOM PROSITE 3.572E-10 4.500E-9 2.438E-8 4.500E-8 6 115
11 SM00020 Tryp SPc SMART 3.966E-10 4.543E-9 2.461E-8 4.997E-8 6 117
12 IPR001254 Trypsin dom InterPro 4.865E-10 4.715E-9 2.554E-8 6.130E-8 6 121
13 PF00089 Trypsin Pfam 4.865E-10 4.715E-9 2.554E-8 6.130E-8 6 121
14 IPR009003 Peptidase S1 PA InterPro 5.374E-10 4.837E-9 2.620E-8 6.771E-8 6 123
15 IPR024175 Pept S1A C1r/C1S/mannan-bd InterPro 2.043E-9 1.716E-8 9.297E-8 2.574E-7 3 4
16 IPR011360 Compl C2 B InterPro 6.838E-7 5.385E-6 2.917E-5 8.616E-5 2 2
17 SM00057 FIMAC SMART 4.099E-6 2.869E-5 1.554E-4 5.164E-4 2 4
18 IPR003884 FacI MAC InterPro 4.099E-6 2.869E-5 1.554E-4 5.164E-4 2 4
19 PF00431 CUB Pfam 9.192E-6 6.096E-5 3.302E-4 1.158E-3 3 49
20 SM00042 CUB SMART 9.774E-6 6.158E-5 3.336E-4 1.232E-3 3 50
21 2.60.120.290 - Gene3D 1.101E-5 6.606E-5 3.579E-4 1.387E-3 3 52
22 PS01180 CUB PROSITE 1.166E-5 6.680E-5 3.619E-4 1.470E-3 3 53
23 IPR000859 CUB dom InterPro 1.454E-5 7.964E-5 4.315E-4 1.832E-3 3 57
24 PS50026 EGF 3 PROSITE 3.966E-5 2.082E-4 1.128E-3 4.997E-3 4 236
25 IPR000742 EGF-like dom InterPro 4.965E-5 2.427E-4 1.315E-3 6.256E-3 4 250
26 PF07645 EGF CA Pfam 5.009E-5 2.427E-4 1.315E-3 6.311E-3 3 86
27 PS00022 EGF 1 PROSITE 5.446E-5 2.541E-4 1.377E-3 6.862E-3 4 256
28 IPR013032 EGF-like CS InterPro 5.959E-5 2.682E-4 1.453E-3 7.509E-3 4 262
29 PS01186 EGF 2 PROSITE 6.321E-5 2.746E-4 1.488E-3 7.964E-3 4 266
30 IPR018097 EGF Ca-bd CS InterPro 7.175E-5 3.013E-4 1.632E-3 9.040E-3 3 97
31 PS01187 EGF CA PROSITE 7.625E-5 3.093E-4 1.676E-3 9.607E-3 3 99
32 PS00010 ASX HYDROXYL PROSITE 7.856E-5 3.093E-4 1.676E-3 9.899E-3 3 100
33 IPR000152 EGF-type Asp/Asn hydroxyl site InterPro 9.344E-5 3.568E-4 1.933E-3 1.177E-2 3 106
34 SM00179 EGF CA SMART 1.418E-4 5.255E-4 2.847E-3 1.787E-2 3 122
35 IPR001881 EGF-like Ca-bd dom InterPro 1.488E-4 5.357E-4 2.902E-3 1.875E-2 3 124
36 IPR023415 LDLR class-A CS InterPro 5.234E-4 1.832E-3 9.923E-3
6.594E-2
 2 40
37 PF00057 Ldl recept a Pfam 6.626E-4 2.256E-3 1.222E-2
8.349E-2
 2 45
38 PS01209 LDLRA 1 PROSITE 7.539E-4 2.339E-3 1.267E-2
9.499E-2
 2 48
39 PS50068 LDLRA 2 PROSITE 7.855E-4 2.339E-3 1.267E-2
9.898E-2
 2 49
40 IPR002172 LDrepeatLR classA rpt InterPro 7.855E-4 2.339E-3 1.267E-2
9.898E-2
 2 49
41 SM00192 LDLa SMART 7.855E-4 2.339E-3 1.267E-2
9.898E-2
 2 49
42 PS51465 KAZAL 2 PROSITE 8.179E-4 2.339E-3 1.267E-2
1.031E-1
 2 50
43 IPR002350 Kazal dom InterPro 8.508E-4 2.339E-3 1.267E-2
1.072E-1
 2 51
44 IPR028341 Complement B InterPro 8.540E-4 2.339E-3 1.267E-2
1.076E-1
 1 1
45 IPR001644 Anaphtx C3AR1 InterPro 8.540E-4 2.339E-3 1.267E-2
1.076E-1
 1 1
46 IPR017341 CD46 InterPro 8.540E-4 2.339E-3 1.267E-2
1.076E-1
 1 1
47 PF00092 VWA Pfam 1.025E-3 2.748E-3 1.489E-2
1.292E-1
 2 56
48 IPR002234 Anphylx rcpt InterPro 1.707E-3 4.482E-3 2.428E-2
2.151E-1
 1 2
49 3.40.50.410 - Gene3D 1.782E-3 4.582E-3 2.482E-2
2.245E-1
 2 74
50 PS50234 VWFA PROSITE 2.182E-3 5.499E-3 2.979E-2
2.750E-1
 2 82
Show 45 more annotations

7: Pathway [Display Chart] 15 input genes in category / 63 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83073 Complement and coagulation cascades BioSystems: KEGG 2.657E-34 1.674E-32 7.914E-32 1.674E-32 15 79
2 1269241 Complement cascade BioSystems: REACTOME 1.983E-33 6.246E-32 2.953E-31 1.249E-31 14 54
3 1269250 Regulation of Complement cascade BioSystems: REACTOME 1.025E-24 2.152E-23 1.018E-22 6.456E-23 10 27
4 172846 Staphylococcus aureus infection BioSystems: KEGG 4.280E-21 6.741E-20 3.187E-19 2.696E-19 10 56
5 M917 Complement Pathway MSigDB C2 BIOCARTA (v6.0) 3.386E-20 4.267E-19 2.017E-18 2.133E-18 8 19
6 M4732 Lectin Induced Complement Pathway MSigDB C2 BIOCARTA (v6.0) 8.919E-16 9.365E-15 4.428E-14 5.619E-14 6 12
7 1269242 Initial triggering of complement BioSystems: REACTOME 1.818E-15 1.636E-14 7.735E-14 1.145E-13 7 31
8 M7146 Classical Complement Pathway MSigDB C2 BIOCARTA (v6.0) 1.356E-9 1.068E-8 5.049E-8 8.542E-8 4 14
9 1269243 Creation of C4 and C2 activators BioSystems: REACTOME 8.067E-9 5.647E-8 2.670E-7 5.082E-7 4 21
10 1269244 Lectin pathway of complement activation BioSystems: REACTOME 2.824E-8 1.779E-7 8.412E-7 1.779E-6 3 6
11 1269248 Activation of C3 and C5 BioSystems: REACTOME 4.938E-8 2.828E-7 1.337E-6 3.111E-6 3 7
12 218111 Pertussis BioSystems: KEGG 1.663E-6 8.732E-6 4.129E-5 1.048E-4 4 76
13 1269247 Alternative complement activation BioSystems: REACTOME 8.118E-6 3.934E-5 1.860E-4 5.114E-4 2 4
14 1269245 Ficolins bind to repetitive carbohydrate structures on the target cell surface BioSystems: REACTOME 1.352E-5 6.084E-5 2.877E-4 8.518E-4 2 5
15 83122 Systemic lupus erythematosus BioSystems: KEGG 1.551E-5 6.514E-5 3.080E-4 9.771E-4 4 133
16 M3952 Cells and Molecules involved in local acute inflammatory response MSigDB C2 BIOCARTA (v6.0) 1.824E-4 7.180E-4 3.395E-3 1.149E-2 2 17
17 153910 Phagosome BioSystems: KEGG 7.571E-4 2.806E-3 1.327E-2 4.770E-2 3 154
18 469200 Legionellosis BioSystems: KEGG 1.939E-3 6.787E-3 3.209E-2
1.222E-1
 2 55
19 1457780 Neutrophil degranulation BioSystems: REACTOME 2.323E-3 7.586E-3 3.587E-2
1.463E-1
 4 492
20 PW:0000503 classical complement Pathway Ontology 2.408E-3 7.586E-3 3.587E-2
1.517E-1
 1 2
21 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v6.0) 2.648E-3 7.944E-3 3.756E-2
1.668E-1
 3 238
22 144181 Leishmaniasis BioSystems: KEGG 3.389E-3 9.705E-3 4.589E-2
2.135E-1
 2 73
23 83078 Hematopoietic cell lineage BioSystems: KEGG 5.905E-3 1.617E-2
7.648E-2
3.720E-1
 2 97
24 1269249 Terminal pathway of complement BioSystems: REACTOME 1.079E-2 2.834E-2
1.340E-1
6.801E-1
 1 9
25 M1473 B Lymphocyte Cell Surface Molecules MSigDB C2 BIOCARTA (v6.0) 1.318E-2 3.321E-2
1.570E-1
8.303E-1
 1 11
26 1269544 GPCR ligand binding BioSystems: REACTOME 1.590E-2 3.852E-2
1.821E-1
1.000E0
 3 455
27 1269246 Classical antibody-mediated complement activation BioSystems: REACTOME 1.793E-2 4.153E-2
1.963E-1
1.000E0
 1 15
28 213780 Tuberculosis BioSystems: KEGG 1.909E-2 4.153E-2
1.963E-1
1.000E0
 2 179
29 M14775 G alpha s Pathway MSigDB C2 BIOCARTA (v6.0) 1.912E-2 4.153E-2
1.963E-1
1.000E0
 1 16
30 1269546 Peptide ligand-binding receptors BioSystems: REACTOME 2.093E-2 4.395E-2
2.078E-1
1.000E0
 2 188
31 M16518 Wnt/Ca2+/cyclic GMP signaling. MSigDB C2 BIOCARTA (v6.0) 2.384E-2 4.845E-2
2.291E-1
1.000E0
 1 20
32 1269899 Scavenging by Class A Receptors BioSystems: REACTOME 2.502E-2 4.926E-2
2.329E-1
1.000E0
 1 21
33 1269370 Intrinsic Pathway of Fibrin Clot Formation BioSystems: REACTOME 2.620E-2 4.927E-2
2.329E-1
1.000E0
 1 22
34 M15997 Intrinsic Prothrombin Activation Pathway MSigDB C2 BIOCARTA (v6.0) 2.737E-2 4.927E-2
2.329E-1
1.000E0
 1 23
35 M15743 G alpha 12 Pathway MSigDB C2 BIOCARTA (v6.0) 2.737E-2 4.927E-2
2.329E-1
1.000E0
 1 23
Show 30 more annotations

8: Pubmed [Display Chart] 16 input genes in category / 3956 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19344414 Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. Pubmed 1.956E-39 7.738E-36 6.856E-35 7.738E-36 13 31
2 23235567 Atypical postinfectious glomerulonephritis is associated with abnormalities in the alternative pathway of complement. Pubmed 1.858E-21 3.676E-18 3.257E-17 7.352E-18 6 6
3 20513133 Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. Pubmed 1.301E-20 1.715E-17 1.520E-16 5.145E-17 6 7
4 20301598 Dense Deposit Disease/Membranoproliferative Glomerulonephritis Type II Pubmed 5.201E-20 5.144E-17 4.558E-16 2.058E-16 6 8
5 20438785 Polymorphisms in innate immunity genes and risk of childhood leukemia. Pubmed 1.301E-19 8.114E-17 7.190E-16 5.147E-16 10 206
6 20406964 Risk of meningioma and common variation in genes related to innate immunity. Pubmed 1.367E-19 8.114E-17 7.190E-16 5.408E-16 10 207
7 19423540 Common variation in genes related to innate immunity and risk of adult glioma. Pubmed 1.436E-19 8.114E-17 7.190E-16 5.680E-16 10 208
8 18842294 Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. Pubmed 1.630E-18 8.058E-16 7.140E-15 6.446E-15 7 32
9 20888482 Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration. Pubmed 3.610E-16 1.587E-13 1.406E-12 1.428E-12 5 8
10 20301541 Genetic Atypical Hemolytic-Uremic Syndrome Pubmed 1.624E-15 5.353E-13 4.743E-12 6.424E-12 5 10
11 23427256 Blocking properdin, the alternative pathway, and anaphylatoxin receptors ameliorates renal ischemia-reperfusion injury in decay-accelerating factor and CD59 double-knockout mice. Pubmed 1.624E-15 5.353E-13 4.743E-12 6.424E-12 5 10
12 22705344 Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. Pubmed 1.624E-15 5.353E-13 4.743E-12 6.424E-12 5 10
13 21665990 Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Pubmed 1.933E-14 4.061E-12 3.598E-11 7.646E-11 5 15
14 20106822 Genetic disorders in complement (regulating) genes in patients with atypical haemolytic uraemic syndrome (aHUS). Pubmed 2.053E-14 4.061E-12 3.598E-11 8.122E-11 4 4
15 30179527 Association Between Complement Factor C2/C3/CFB/CFH Polymorphisms and Age-Related Macular Degeneration: A Meta-Analysis. Pubmed 2.053E-14 4.061E-12 3.598E-11 8.122E-11 4 4
16 24983375 Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components. Pubmed 2.053E-14 4.061E-12 3.598E-11 8.122E-11 4 4
17 10946292 Proteolytic activities of two types of mannose-binding lectin-associated serine protease. Pubmed 2.053E-14 4.061E-12 3.598E-11 8.122E-11 4 4
18 25188723 New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3. Pubmed 2.053E-14 4.061E-12 3.598E-11 8.122E-11 4 4
19 23233260 Association between polymorphisms of complement pathway genes and age-related macular degeneration in a Chinese population. Pubmed 2.053E-14 4.061E-12 3.598E-11 8.122E-11 4 4
20 19399715 [Polymorphisms of complement factor genes and age-related macular degeneration in a German population]. Pubmed 2.053E-14 4.061E-12 3.598E-11 8.122E-11 4 4
21 20385826 Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Pubmed 2.811E-14 5.295E-12 4.691E-11 1.112E-10 5 16
22 16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Pubmed 4.629E-14 8.324E-12 7.376E-11 1.831E-10 8 257
23 20385819 Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Pubmed 5.510E-14 9.478E-12 8.398E-11 2.180E-10 5 18
24 23390291 Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack. Pubmed 1.026E-13 1.400E-11 1.240E-10 4.060E-10 4 5
25 20523265 Association study of complement factor H, C2, CFB, and C3 and age-related macular degeneration in a Han Chinese population. Pubmed 1.026E-13 1.400E-11 1.240E-10 4.060E-10 4 5
26 24453474 CFH haplotypes and ARMS2, C2, C3, and CFB alleles show association with susceptibility to age-related macular degeneration in Mexicans. Pubmed 1.026E-13 1.400E-11 1.240E-10 4.060E-10 4 5
27 20157618 Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort. Pubmed 1.026E-13 1.400E-11 1.240E-10 4.060E-10 4 5
28 23526211 Inhibition of complement activation alleviates acute lung injury induced by highly pathogenic avian influenza H5N1 virus infection. Pubmed 1.026E-13 1.400E-11 1.240E-10 4.060E-10 4 5
29 18936151 Peripheral retinal drusen and reticular pigment: association with CFHY402H and CFHrs1410996 genotypes in family and twin studies. Pubmed 1.026E-13 1.400E-11 1.240E-10 4.060E-10 4 5
30 19117936 Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Pubmed 3.078E-13 3.690E-11 3.269E-10 1.218E-9 4 6
31 18947875 Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury. Pubmed 3.078E-13 3.690E-11 3.269E-10 1.218E-9 4 6
32 10878362 Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19. Pubmed 3.078E-13 3.690E-11 3.269E-10 1.218E-9 4 6
33 19661236 Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Pubmed 3.078E-13 3.690E-11 3.269E-10 1.218E-9 4 6
34 19259132 Multilocus analysis of age-related macular degeneration. Pubmed 7.181E-13 7.891E-11 6.991E-10 2.841E-9 4 7
35 14670299 Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway. Pubmed 7.181E-13 7.891E-11 6.991E-10 2.841E-9 4 7
36 19861685 Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome. Pubmed 7.181E-13 7.891E-11 6.991E-10 2.841E-9 4 7
37 23455636 Seven new loci associated with age-related macular degeneration. Pubmed 9.139E-13 9.771E-11 8.657E-10 3.615E-9 5 30
38 20059470 Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome. Pubmed 2.584E-12 2.690E-10 2.383E-9 1.022E-8 4 9
39 17330941 Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. Pubmed 6.941E-12 7.041E-10 6.238E-9 2.746E-8 5 44
40 19015224 Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss. Pubmed 2.050E-11 1.978E-9 1.753E-8 8.110E-8 4 14
41 23577725 Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. Pubmed 2.050E-11 1.978E-9 1.753E-8 8.110E-8 4 14
42 16944957 Proteome-wide characterization of N-glycosylation events by diagonal chromatography. Pubmed 2.218E-11 2.089E-9 1.851E-8 8.773E-8 5 55
43 26787717 Deficiency of the Complement Component 3 but Not Factor B Aggravates Staphylococcus aureus Septic Arthritis in Mice. Pubmed 6.031E-11 3.615E-9 3.203E-8 2.386E-7 3 3
44 1401896 Ultrastructures and interactions of complement factors H and I. Pubmed 6.031E-11 3.615E-9 3.203E-8 2.386E-7 3 3
45 21163532 Disruption of the alternative pathway convertase occurs at the staphylococcal surface via the acquisition of factor H by Staphylococcus aureus. Pubmed 6.031E-11 3.615E-9 3.203E-8 2.386E-7 3 3
46 19899988 Association of c3 gene polymorphisms with neovascular age-related macular degeneration in a chinese population. Pubmed 6.031E-11 3.615E-9 3.203E-8 2.386E-7 3 3
47 10925294 Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2. Pubmed 6.031E-11 3.615E-9 3.203E-8 2.386E-7 3 3
48 28671664 Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses. Pubmed 6.031E-11 3.615E-9 3.203E-8 2.386E-7 3 3
49 22273503 Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population. Pubmed 6.031E-11 3.615E-9 3.203E-8 2.386E-7 3 3
50 17767156 Variation in complement factor 3 is associated with risk of age-related macular degeneration. Pubmed 6.031E-11 3.615E-9 3.203E-8 2.386E-7 3 3
Show 45 more annotations

9: Interaction [Display Chart] 16 input genes in category / 265 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:C3 C3 interactions 9.778E-23 2.591E-20 1.596E-19 2.591E-20 10 50
2 int:MASP1 MASP1 interactions 2.501E-14 3.314E-12 2.041E-11 6.629E-12 6 24
3 int:MASP2 MASP2 interactions 2.223E-12 1.964E-10 1.209E-9 5.891E-10 4 5
4 int:C2 C2 interactions 3.107E-11 2.059E-9 1.268E-8 8.235E-9 4 8
5 int:SERPING1 SERPING1 interactions 2.137E-9 1.133E-7 6.975E-7 5.663E-7 4 20
6 int:CFI CFI interactions 6.051E-9 2.672E-7 1.646E-6 1.603E-6 3 5
7 int:CR1 CR1 interactions 2.115E-8 8.008E-7 4.932E-6 5.606E-6 3 7
8 int:MBL2 MBL2 interactions 9.950E-8 3.296E-6 2.030E-5 2.637E-5 3 11
9 int:C5 C5 interactions 1.326E-7 3.904E-6 2.405E-5 3.514E-5 3 12
10 int:CFH CFH interactions 9.231E-7 2.446E-5 1.507E-4 2.446E-4 3 22
11 int:CD55 CD55 interactions 2.957E-6 7.123E-5 4.387E-4 7.835E-4 3 32
12 int:FCN2 FCN2 interactions 4.590E-6 1.014E-4 6.243E-4 1.216E-3 2 4
13 int:CFHR3 CFHR3 interactions 7.646E-6 1.447E-4 8.914E-4 2.026E-3 2 5
14 int:CFHR5 CFHR5 interactions 7.646E-6 1.447E-4 8.914E-4 2.026E-3 2 5
15 int:C1S C1S interactions 2.138E-5 3.776E-4 2.326E-3 5.665E-3 2 8
16 int:C1R C1R interactions 4.192E-5 6.535E-4 4.025E-3 1.111E-2 2 11
17 int:CFP CFP interactions 4.192E-5 6.535E-4 4.025E-3 1.111E-2 2 11
18 int:CR2 CR2 interactions 5.028E-5 7.402E-4 4.559E-3 1.332E-2 2 12
19 int:CFB CFB interactions 7.986E-5 1.114E-3 6.860E-3 2.116E-2 2 15
20 int:CD46 CD46 interactions 9.123E-5 1.209E-3 7.444E-3 2.417E-2 2 16
21 int:ITGAM ITGAM interactions 1.916E-4 2.418E-3 1.489E-2
5.078E-2
 2 23
22 int:C4A C4A interactions 2.270E-4 2.734E-3 1.684E-2
6.015E-2
 2 25
23 int:GDPD1 GDPD1 interactions 3.065E-4 3.532E-3 2.175E-2
8.123E-2
 2 29
24 int:C1QA C1QA interactions 3.978E-4 4.393E-3 2.705E-2
1.054E-1
 2 33
25 int:F2 F2 interactions 7.086E-4 7.511E-3 4.626E-2
1.878E-1
 2 44
26 int:ALB ALB interactions 8.451E-4 8.613E-3
5.305E-2
2.239E-1
 3 212
27 int:CFHR4 CFHR4 interactions 2.709E-3 2.564E-2
1.579E-1
7.179E-1
 1 3
28 int:DMP1 DMP1 interactions 2.709E-3 2.564E-2
1.579E-1
7.179E-1
 1 3
29 int:C3AR1 C3AR1 interactions 3.256E-3 2.975E-2
1.832E-1
8.628E-1
 2 95
30 int:C1RL C1RL interactions 4.511E-3 3.736E-2
2.301E-1
1.000E0
 1 5
31 int:C4B C4B interactions 4.511E-3 3.736E-2
2.301E-1
1.000E0
 1 5
32 int:ITGAX ITGAX interactions 4.511E-3 3.736E-2
2.301E-1
1.000E0
 1 5
33 int:DDX19B DDX19B interactions 4.811E-3 3.863E-2
2.379E-1
1.000E0
 2 116
34 int:CFHR1 CFHR1 interactions 5.411E-3 4.097E-2
2.523E-1
1.000E0
 1 6
35 int:FUT4 FUT4 interactions 5.411E-3 4.097E-2
2.523E-1
1.000E0
 1 6
36 int:CHI3L1 CHI3L1 interactions 6.311E-3 4.520E-2
2.784E-1
1.000E0
 1 7
37 int:ADM ADM interactions 6.311E-3 4.520E-2
2.784E-1
1.000E0
 1 7
38 int:ADGRL3 ADGRL3 interactions 7.209E-3 4.849E-2
2.986E-1
1.000E0
 1 8
39 int:ZDHHC21 ZDHHC21 interactions 8.107E-3 4.849E-2
2.986E-1
1.000E0
 1 9
40 int:DPY19L3 DPY19L3 interactions 8.107E-3 4.849E-2
2.986E-1
1.000E0
 1 9
41 int:GPLD1 GPLD1 interactions 9.004E-3 4.849E-2
2.986E-1
1.000E0
 1 10
42 int:ELOVL2 ELOVL2 interactions 9.004E-3 4.849E-2
2.986E-1
1.000E0
 1 10
43 int:CPN1 CPN1 interactions 9.004E-3 4.849E-2
2.986E-1
1.000E0
 1 10
44 int:TMEM68 TMEM68 interactions 9.004E-3 4.849E-2
2.986E-1
1.000E0
 1 10
45 int:AGPAT4 AGPAT4 interactions 9.900E-3 4.849E-2
2.986E-1
1.000E0
 1 11
46 int:TRIM16L TRIM16L interactions 9.900E-3 4.849E-2
2.986E-1
1.000E0
 1 11
47 int:TSPAN4 TSPAN4 interactions 9.900E-3 4.849E-2
2.986E-1
1.000E0
 1 11
48 int:C6 C6 interactions 9.900E-3 4.849E-2
2.986E-1
1.000E0
 1 11
49 int:SELP SELP interactions 9.900E-3 4.849E-2
2.986E-1
1.000E0
 1 11
50 int:CERS5 CERS5 interactions 9.900E-3 4.849E-2
2.986E-1
1.000E0
 1 11
Show 45 more annotations

10: Cytoband [Display Chart] 16 input genes in category / 12 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1q32 1q32 6.334E-9 7.600E-8 2.359E-7 7.600E-8 4 49
2 1p36.3-p36.2 1p36.3-p36.2 1.845E-3 7.381E-3 2.290E-2 2.214E-2 1 4
3 3q27-q28 3q27-q28 1.845E-3 7.381E-3 2.290E-2 2.214E-2 1 4
4 6p21.3 6p21.3 6.136E-3 1.173E-2 3.640E-2
7.364E-2
 2 257
5 19p13.3-p13.2 19p13.3-p13.2 6.444E-3 1.173E-2 3.640E-2
7.733E-2
 1 14
6 1q31.3 1q31.3 7.362E-3 1.173E-2 3.640E-2
8.834E-2
 1 16
7 5p13 5p13 7.820E-3 1.173E-2 3.640E-2
9.384E-2
 1 17
8 10q11.2 10q11.2 7.820E-3 1.173E-2 3.640E-2
9.384E-2
 1 17
9 12p13 12p13 3.004E-2 3.659E-2
1.135E-1
3.605E-1
 1 66
10 4q25 4q25 3.049E-2 3.659E-2
1.135E-1
3.659E-1
 1 67
11 12p13.31 12p13.31 3.764E-2 4.106E-2
1.274E-1
4.517E-1
 1 83
Show 6 more annotations

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 46 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 16 input genes in category / 10 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 492 Complement system|Sushi domain containing genenames.org 1.444E-27 1.444E-26 4.229E-26 1.444E-26 11 36
2 1179 Apolipoproteins|Sushi domain containing genenames.org 4.411E-25 2.205E-24 6.460E-24 4.411E-24 11 57
3 454 Blood group antigens genenames.org 4.743E-4 1.581E-3 4.631E-3 4.743E-3 2 37
4 196 Complement component GPCRs|CD molecules|Complement system genenames.org 2.636E-3 6.590E-3 1.930E-2 2.636E-2 1 3
5 471 CD molecules|Tumor necrosis factor superfamily genenames.org 4.576E-3 9.152E-3 2.681E-2 4.576E-2 3 394
6 1234 C3 and PZP like, alpha-2-macroglobulin domain containing genenames.org 7.889E-3 1.252E-2 3.666E-2
7.889E-2
 1 9
7 491 Collectins|Scavenger receptors|C-type lectin domain containing genenames.org 8.762E-3 1.252E-2 3.666E-2
8.762E-2
 1 10
8 739 Serpin peptidase inhibitors genenames.org 3.206E-2 4.007E-2
1.174E-1
3.206E-1
 1 37
Show 3 more annotations

13: Coexpression [Display Chart] 16 input genes in category / 1641 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5946 Genes encoding components of blood coagulation system; also up-regulated in platelets. MSigDB H: Hallmark Gene Sets (v6.0) 8.096E-17 1.329E-13 1.060E-12 1.329E-13 9 138
2 M5921 Genes encoding components of the complement system, which is part of the innate immune system. MSigDB H: Hallmark Gene Sets (v6.0) 2.441E-15 2.003E-12 1.599E-11 4.006E-12 9 200
3 15342375-Table2 Human Prostate Ashida04 63genes GeneSigDB 1.662E-12 9.089E-10 7.253E-9 2.727E-9 6 59
4 M13283 Liver selective genes MSigDB C2: CGP Curated Gene Sets (v6.0) 1.404E-10 5.762E-8 4.598E-7 2.305E-7 7 244
5 18318837-Table1 Human MesenchymalStemCells Yamamoto08 83genes GeneSigDB 1.731E-9 5.681E-7 4.534E-6 2.840E-6 5 79
6 M9576 Genes down-regulated in T reg: peripheral lymph nodes versus thymic CD24 int [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v6.0) 1.856E-7 3.443E-5 2.748E-4 3.046E-4 5 200
7 M9586 Genes down-regulated in thymic T reg: CD24 high [GeneID=100133941] versus CD24 int [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v6.0) 1.856E-7 3.443E-5 2.748E-4 3.046E-4 5 200
8 M9595 Genes down-regulated in thymic T conv: CD24 high [GeneID=100133941] versus CD24 low [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v6.0) 1.856E-7 3.443E-5 2.748E-4 3.046E-4 5 200
9 M9206 Genes down-regulated in hepatocellular carcinoma (HCC) cells with hepatic stem cell properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.898E-7 3.443E-5 2.748E-4 3.115E-4 4 76
10 M12225 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.098E-7 3.443E-5 2.748E-4 3.443E-4 5 205
11 M10454 Genes up-regulated in pulpal tissue extracted from carious teeth. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.949E-7 8.875E-5 7.083E-4 9.762E-4 5 253
12 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.807E-7 9.309E-5 7.429E-4 1.117E-3 5 260
13 17206280-TableS1C Mouse Breast Park07 173genes GeneSigDB 1.643E-6 2.075E-4 1.656E-3 2.697E-3 4 130
14 M2194 Genes down-regulated in liver samples of liver-specific knockout of HNF4A [GeneID=3172]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.831E-6 3.253E-4 2.596E-3 4.645E-3 4 149
15 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.973E-6 3.253E-4 2.596E-3 4.879E-3 5 351
16 M2398 Genes down-regulated in liver tissue upon knockout of HNF1A [GeneID=6927]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.485E-6 3.574E-4 2.853E-3 5.719E-3 4 157
17 18435859-ShorterGeneList Mouse Breast Piechocki08 558genes GeneSigDB 4.160E-6 4.016E-4 3.205E-3 6.827E-3 5 376
18 M6145 Genes highly expressed in hepatocellular carcinoma with good survival. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.680E-6 6.060E-4 4.836E-3 1.096E-2 4 185
19 M9568 Genes up-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 [GeneID=10219] knockout versus BCL2L11 [GeneID=10018] knockout. MSigDB C7: Immunologic Signatures (v6.0) 8.912E-6 6.060E-4 4.836E-3 1.462E-2 4 199
20 M7655 Genes up-regulated in skin gamma delta T cells: healthy versus obesity. MSigDB C7: Immunologic Signatures (v6.0) 8.912E-6 6.060E-4 4.836E-3 1.462E-2 4 199
21 M7650 Genes up-regulated in CD4 [GeneID=920] T cells under specific pathogen free conditions: healthy versus arthritis (KRN model). MSigDB C7: Immunologic Signatures (v6.0) 9.090E-6 6.060E-4 4.836E-3 1.492E-2 4 200
22 M9572 Genes up-regulated in cells from peripheral lymph nodes: T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 9.090E-6 6.060E-4 4.836E-3 1.492E-2 4 200
23 M8844 Genes up-regulated in NK cells: RAG2 [GeneID=5897] knockout versus RAG2 and ETS1 [GeneID=5897;2113] knockout. MSigDB C7: Immunologic Signatures (v6.0) 9.090E-6 6.060E-4 4.836E-3 1.492E-2 4 200
24 M5913 Genes up-regulated in response to IFNG [GeneID=3458]. MSigDB H: Hallmark Gene Sets (v6.0) 9.090E-6 6.060E-4 4.836E-3 1.492E-2 4 200
25 M3645 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.232E-6 6.060E-4 4.836E-3 1.515E-2 5 443
26 18006812-TableS1 Human Lymphoma Piccaluga07 260genes GeneSigDB 9.829E-6 6.204E-4 4.951E-3 1.613E-2 4 204
27 19061838-TableS3 Human Viral Cairo08 588genes GeneSigDB 1.179E-5 7.086E-4 5.655E-3 1.936E-2 5 466
28 M707 Genes down-regulated in mucinous ovarian carcinoma tumors of grades 1 and 2 compared to the normal ovarian survace epithelium tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.209E-5 7.086E-4 5.655E-3 1.984E-2 3 66
29 M8513 Genes up-regulated in the normal-like subtype of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.307E-5 7.370E-4 5.882E-3 2.145E-2 5 476
30 M9893 Genes whose expression increases with age in normal kidney, excluding those with higher expression in blood. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.347E-5 7.370E-4 5.882E-3 2.211E-2 4 221
31 M11428 Inflammatory cytokines, chemokines and their cognate receptors up-regulated in THP-1 cells (monocyte) after treatment with PSMD4 [GeneID=5710]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.638E-5 8.673E-4 6.922E-3 2.689E-2 3 73
32 M17951 Top 100 probe sets contrubuting to the positive side of the 1st principal component; predominantly associated with spindle cell and pleomorphic sarcoma samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.850E-5 9.485E-4 7.569E-3 3.035E-2 3 76
33 M1286 Genes from 'subtype S3' signature of hepatocellular carcinoma (HCC): hepatocyte differentiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.788E-5 1.366E-3 1.090E-2 4.575E-2 4 266
34 M13449 Genes down-regulated in hepatoblastoma samples compared to normal liver tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.829E-5 1.366E-3 1.090E-2 4.643E-2 4 267
35 19096012-TableS3 Human Viral Chetaille09 425genes GeneSigDB 7.935E-5 3.720E-3 2.969E-2
1.302E-1
 4 348
36 17023518-Table1 Mouse Lung not cancer Chen06 23genes GeneSigDB 8.457E-5 3.855E-3 3.076E-2
1.388E-1
 2 20
37 19061838-TableS6b Human Viral Cairo08 52genes GeneSigDB 1.125E-4 4.988E-3 3.981E-2
1.846E-1
 2 23
38 15756260-Table1 Human Liver Shi05 30genes GeneSigDB 1.558E-4 6.728E-3
5.369E-2
2.557E-1
 2 27
39 M3654 Genes up-regulated in samples with systolic heart failure compared to normal hearts. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.669E-4 6.863E-3
5.477E-2
2.738E-1
 4 422
40 M1806 Direct targets of FOXA2 [GeneID=3170] in liver, according to a ChIP-chip analysis. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.715E-4 6.863E-3
5.477E-2
2.814E-1
 4 425
41 18277965-TableS1b Human Liver Skawran08 551genes GeneSigDB 1.715E-4 6.863E-3
5.477E-2
2.814E-1
 4 425
42 M15069 Genes up-regulated in A549 cells (lung carcinoma) upon infection with RSV (respiratory syncytial virus) and up-regulated by further treatment with ribavirin [PubChem=5064]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.928E-4 7.272E-3
5.804E-2
3.165E-1
 2 30
43 M12175 Genes significantly up-regulated in the blood mononuclear cells from patients with systemic lupus erythematosus compared to those from healthy persons. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.061E-4 7.272E-3
5.804E-2
3.381E-1
 2 31
44 17683608-TableS1 Mouse StemCell Ulloa-Montoya07 546genes GeneSigDB 2.153E-4 7.272E-3
5.804E-2
3.532E-1
 4 451
45 M14507 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.208E-4 7.272E-3
5.804E-2
3.623E-1
 4 454
46 15297395-SuppTable1 Human Lymphoma Sriuranpong04 670genes Epithelium(N)Metaplastic/DisplasticLesions(R)Carcinoma(T) GeneSigDB 2.245E-4 7.272E-3
5.804E-2
3.684E-1
 4 456
47 M16932 Top 200 marker genes down-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation, high levels of serum AFP [GeneID=174], and chromosomal instability. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.368E-4 7.272E-3
5.804E-2
3.885E-1
 3 179
48 M4785 Genes down-regulated in monocyte-derived dendritic cells (MDDC) after stimulation with galecin-1 (lectin, LGALS1) [GeneID=3956] compared to that with bacterial lipopolysaccharide (LPS). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.380E-4 7.272E-3
5.804E-2
3.905E-1
 4 463
49 15374961-TableS2 Human Brain Freije04 595genes GeneSigDB 2.603E-4 7.272E-3
5.804E-2
4.271E-1
 4 474
50 18277965-Table5 Human Liver Skawran08 43genes ComparisonGeneSetEnrichment GeneSigDB 2.786E-4 7.272E-3
5.804E-2
4.572E-1
 2 36
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 16 input genes in category / 1566 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap kidney adult RenalCapsule k3 200 kidney adult RenalCapsule k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.224E-10 1.519E-7 1.205E-6 1.916E-7 6 112
2 liver liver Human Protein Atlas 1.940E-10 1.519E-7 1.205E-6 3.038E-7 8 419
3 gudmap kidney adult RenalCapsule 200 kidney adult RenalCapsule top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.889E-9 9.860E-7 7.823E-6 2.958E-6 6 176
4 gudmap kidney adult RenalCapsule 100 kidney adult RenalCapsule top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 4.239E-9 1.660E-6 1.317E-5 6.639E-6 5 89
5 GSM777043 100 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 6.560E-9 2.022E-6 1.604E-5 1.027E-5 5 97
6 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.747E-9 2.022E-6 1.604E-5 1.213E-5 7 410
7 gudmap kidney adult RenalCapsule k1 500 kidney adult RenalCapsule k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.273E-8 2.849E-6 2.260E-5 1.994E-5 6 242
8 gudmap kidney adult JuxtaGlom Ren1 Captopr k3 200 kidney adult JuxtaGlom Ren1 Captopr k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.805E-8 3.485E-6 2.765E-5 2.827E-5 3 8
9 gudmap developingLowerUrinaryTract P1 ureter 1000 k1 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.003E-8 3.485E-6 2.765E-5 3.137E-5 5 121
10 gudmap developingLowerUrinaryTract P1 ureter 500 k4 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.368E-8 5.274E-6 4.184E-5 5.274E-5 4 47
11 GSM854276 500 Myeloid Cells, DC.11cloSer.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-lo CD11b+, Small Intestine, avg-4 Immgen.org, GSE15907 1.435E-7 2.043E-5 1.621E-4 2.247E-4 6 364
12 gudmap kidney adult RenalCapsule k2 1000 kidney adult RenalCapsule k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.605E-7 2.095E-5 1.662E-4 2.514E-4 6 371
13 GSM777067 100 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 3.760E-7 4.225E-5 3.352E-4 5.888E-4 4 85
14 GSM777055 100 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 3.941E-7 4.225E-5 3.352E-4 6.172E-4 4 86
15 GSM777050 100 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 4.130E-7 4.225E-5 3.352E-4 6.467E-4 4 87
16 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 4.316E-7 4.225E-5 3.352E-4 6.759E-4 6 439
17 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 4.990E-7 4.596E-5 3.647E-4 7.814E-4 6 450
18 gudmap kidney adult JuxtaGlom Ren1 Captopr k3 500 kidney adult JuxtaGlom Ren1 Captopr k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.047E-6 9.106E-5 7.224E-4 1.639E-3 3 28
19 gudmap kidney adult JuxtaGlom Ren1 Captopr k2 100 kidney adult JuxtaGlom Ren1 Captopr k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.510E-6 1.245E-4 9.877E-4 2.365E-3 2 3
20 gudmap developingGonad P2 epididymis 1000 k5 DevelopingGonad P2 epididymis emap-30199 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.858E-6 2.238E-4 1.776E-3 4.476E-3 4 141
21 gudmap kidney adult Mesangium Meis k4 500 kidney adult Mesangium Meis k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.140E-6 2.341E-4 1.857E-3 4.917E-3 3 40
22 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver Tabula Muris Consortium 4.272E-6 3.041E-4 2.413E-3 6.690E-3 4 156
23 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Hilar/Perihilar/5 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Hilar/Perihilar/5 TCGA-Bile Duct 5.337E-6 3.343E-4 2.652E-3 8.357E-3 4 165
24 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Embryonal Carcinoma/5/1 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Embryonal Carcinoma/5/1 TCGA-Testes 5.337E-6 3.343E-4 2.652E-3 8.357E-3 4 165
25 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/hepatocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/hepatocyte Tabula Muris Consortium 5.337E-6 3.343E-4 2.652E-3 8.357E-3 4 165
26 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter T U/Ureter Normal Wilms T U/Ureter Normal Wilms T21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter T U/Ureter Normal Wilms T U/Ureter Normal Wilms T21 Adult, Development, and Cancer types 6.201E-6 3.596E-4 2.853E-3 9.710E-3 3 50
27 gudmap kidney e13.5 Podocyte MafB k2 500 kidney e13.5 Podocyte MafB k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.201E-6 3.596E-4 2.853E-3 9.710E-3 3 50
28 GSM854322 500 Myeloid Cells, MF.Medl.SLN, CD11b+ CD169+ F4/80+, Lymph Node, avg-2 Immgen.org, GSE15907 6.672E-6 3.648E-4 2.894E-3 1.045E-2 5 391
29 gudmap developingLowerUrinaryTract P1 ureter 500 DevelopingLowerUrinaryTract P1 ureter emap-30363 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.755E-6 3.648E-4 2.894E-3 1.058E-2 5 392
30 GSM538239 500 Myeloid Cells, DC.103-11b+.Lv, CD45+ CD11c+ MHC-II + CD11b high CD103-, Liver, avg-3 Immgen.org, GSE15907 8.500E-6 4.149E-4 3.292E-3 1.331E-2 5 411
31 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Mammary Gland/stromal cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Mammary Gland/stromal cell Tabula Muris Consortium 8.944E-6 4.149E-4 3.292E-3 1.401E-2 4 188
32 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Fat Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Fat Tabula Muris Consortium 8.944E-6 4.149E-4 3.292E-3 1.401E-2 4 188
33 gudmap kidney adult JuxtaGlom Ren1 Captopr k3 1000 kidney adult JuxtaGlom Ren1 Captopr k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 9.228E-6 4.149E-4 3.292E-3 1.445E-2 3 57
34 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Diaphrag/mesenchymal stem cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Diaphrag/mesenchymal stem cell Tabula Muris Consortium 9.521E-6 4.149E-4 3.292E-3 1.491E-2 4 191
35 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/fibroblast Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/fibroblast Tabula Muris Consortium 9.719E-6 4.149E-4 3.292E-3 1.522E-2 4 192
36 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Lung/stromal cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Lung/stromal cell Tabula Muris Consortium 9.920E-6 4.149E-4 3.292E-3 1.554E-2 4 193
37 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Aorta/fibroblast Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Aorta/fibroblast Tabula Muris Consortium 9.920E-6 4.149E-4 3.292E-3 1.554E-2 4 193
38 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea/mesenchymal cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea/mesenchymal cell Tabula Muris Consortium 1.033E-5 4.149E-4 3.292E-3 1.618E-2 4 195
39 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Adenocarcinoma/5 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Adenocarcinoma/5 TCGA-Esophagus 1.033E-5 4.149E-4 3.292E-3 1.618E-2 4 195
40 GSM605850 500 Myeloid Cells, MF.II-480hi.PC, F4/80hi CD115hi CD11b+ MHC II- CD11c-, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 1.157E-5 4.529E-4 3.593E-3 1.812E-2 5 438
41 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 1.249E-5 4.657E-4 3.695E-3 1.956E-2 5 445
42 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter U U/Ureter Normal Wilms U U/Ureter Normal Wilms U21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter U U/Ureter Normal Wilms U U/Ureter Normal Wilms U21 Adult, Development, and Cancer types 1.249E-5 4.657E-4 3.695E-3 1.956E-2 3 63
43 gudmap developingLowerUrinaryTract adult bladder 1000 k3 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.332E-5 4.839E-4 3.839E-3 2.087E-2 4 208
44 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 1.361E-5 4.839E-4 3.839E-3 2.132E-2 5 453
45 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 1.391E-5 4.839E-4 3.839E-3 2.178E-2 5 455
46 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 1.577E-5 5.368E-4 4.259E-3 2.469E-2 5 467
47 gudmap developingGonad P2 epididymis 500 k1 DevelopingGonad P2 epididymis emap-30199 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.791E-5 5.968E-4 4.735E-3 2.805E-2 3 71
48 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 1000 k3 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.945E-5 6.345E-4 5.034E-3 3.046E-2 4 229
49 gudmap developingGonad e18.5 ovary 500 k4 DevelopingGonad e18.5 ovary emap-12283 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.662E-5 8.508E-4 6.750E-3 4.169E-2 3 81
50 GSM605850 100 Myeloid Cells, MF.II-480hi.PC, F4/80hi CD115hi CD11b+ MHC II- CD11c-, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 3.186E-5 9.978E-4 7.917E-3 4.989E-2 3 86
Show 45 more annotations

15: Computational [Display Chart] 13 input genes in category / 99 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M14677 MODULE 58 Genes in the cancer module 58. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.372E-23 7.298E-21 3.778E-20 7.298E-21 9 21
2 M14084 MODULE 130 Complement. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.048E-22 1.014E-20 5.249E-20 2.028E-20 9 23
3 M15983 MODULE 46 Genes in the cancer module 46. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.164E-14 5.988E-13 3.100E-12 2.142E-12 11 394
4 M12401 MODULE 75 Immune response. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.419E-14 5.988E-13 3.100E-12 2.395E-12 11 398
5 M14108 GNF2 HPX Neighborhood of HPX MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.413E-9 1.666E-7 8.624E-7 8.329E-7 6 135
6 M13003 MODULE 109 Serine proteases. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.357E-7 2.239E-6 1.159E-5 1.343E-5 4 39
7 M132 GNF2 LCAT Neighborhood of LCAT MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.156E-7 4.464E-6 2.311E-5 3.125E-5 5 124
8 M10917 GNF2 HPN Neighborhood of HPN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.478E-7 5.542E-6 2.869E-5 4.433E-5 5 133
9 M17376 MODULE 107 Genes in the cancer module 107. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.409E-6 2.649E-5 1.372E-4 2.384E-4 4 79
10 M15716 MODULE 209 Catabolic peptidases. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.886E-6 3.847E-5 1.992E-4 3.847E-4 4 89
11 M10041 MODULE 172 Genes in the cancer module 172. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.260E-6 4.734E-5 2.451E-4 5.208E-4 4 96
12 M18034 CAR IGFBP1 Neighborhood of IGFBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.770E-5 3.936E-4 2.038E-3 4.723E-3 3 57
13 M6913 CAR HPX Neighborhood of HPX MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.002E-4 7.630E-4 3.950E-3 9.919E-3 3 73
14 M5702 MODULE 24 Fetal liver genes - metabolism and xenobiotics. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.744E-4 1.233E-3 6.386E-3 1.727E-2 5 453
15 M10693 GNF2 GSTM1 Neighborhood of GSTM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.292E-4 2.173E-3 1.125E-2 3.259E-2 3 109
16 M15336 MODULE 6 Trachea genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.543E-3 9.548E-3 4.943E-2
1.528E-1
 4 416
17 M6257 MODULE 164 Enzyme inhibitors (esp serine proteases). MSigDb: C4 - CM: Cancer Modules (v6.0) 2.714E-3 1.581E-2
8.184E-2
2.687E-1
 2 61
18 M3221 GNF2 CEBPA Neighborhood of CEBPA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.984E-3 1.641E-2
8.497E-2
2.954E-1
 2 64
19 M17322 MODULE 76 Inflammatory response. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.736E-3 2.468E-2
1.278E-1
4.689E-1
 2 81
20 M7214 MORF SUPT3H Neighborhood of SUPT3H MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.947E-3 3.778E-2
1.956E-1
7.868E-1
 3 331
21 M15658 MORF ATF2 Neighborhood of ATF2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.014E-3 3.778E-2
1.956E-1
7.934E-1
 3 332
22 M688 MODULE 27 Genes in the cancer module 27. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.634E-3 4.335E-2
2.245E-1
9.538E-1
 3 355
23 M12584 MODULE 289 Genes in the cancer module 289. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.080E-2 4.650E-2
2.408E-1
1.000E0
 2 124
Show 18 more annotations

16: MicroRNA [Display Chart] 16 input genes in category / 319 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-3692-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.621E-4 4.465E-2
2.833E-1
1.155E-1
 2 127
2 hsa-miR-5697:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.616E-4 4.465E-2
2.833E-1
2.111E-1
 2 172
3 hsa-miR-519e-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.727E-4 4.465E-2
2.833E-1
2.465E-1
 2 186
4 hsa-miR-515-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.975E-4 4.465E-2
2.833E-1
2.544E-1
 2 189
5 hsa-miR-4465:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.059E-4 4.465E-2
2.833E-1
2.571E-1
 2 190
6 hsa-miR-1297:Functional MTI Functional MTI miRTarbase 8.399E-4 4.465E-2
2.833E-1
2.679E-1
 2 194
7 hsa-miR-216a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.321E-3 4.603E-2
2.920E-1
4.215E-1
 2 244
8 hsa-miR-3681-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.321E-3 4.603E-2
2.920E-1
4.215E-1
 2 244
9 hsa-miR-3192-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.697E-3 4.603E-2
2.920E-1
5.412E-1
 2 277
10 hsa-miR-4753-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.212E-3 4.603E-2
2.920E-1
7.055E-1
 2 317
11 hsa-miR-6809-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.267E-3 4.603E-2
2.920E-1
7.231E-1
 2 321
12 hsa-miR-6817-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.294E-3 4.603E-2
2.920E-1
7.319E-1
 2 323
13 hsa-miR-4772-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.422E-3 4.603E-2
2.920E-1
7.725E-1
 2 332
14 hsa-miR-4635:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.465E-3 4.603E-2
2.920E-1
7.862E-1
 2 335
15 hsa-miR-340-5p:Functional MTI Functional MTI miRTarbase 2.552E-3 4.603E-2
2.920E-1
8.140E-1
 2 341
16 hsa-miR-130b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.596E-3 4.603E-2
2.920E-1
8.281E-1
 2 344
17 hsa-miR-554:mirSVR highEffct hsa-miR-554:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.700E-3 4.603E-2
2.920E-1
8.614E-1
 2 351
18 hsa-miR-3683:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.876E-3 4.603E-2
2.920E-1
9.173E-1
 1 13
19 hsa-miR-1251:mirSVR highEffct hsa-miR-1251:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.572E-3 4.603E-2
2.920E-1
1.000E0
 2 405
20 hsa-miR-675:mirSVR lowEffct hsa-miR-675:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.693E-3 4.603E-2
2.920E-1
1.000E0
 2 412
21 hsa-miR-450a-5p:Functional MTI Functional MTI miRTarbase 3.759E-3 4.603E-2
2.920E-1
1.000E0
 1 17
22 hsa-miR-4793-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.799E-3 4.603E-2
2.920E-1
1.000E0
 2 418
23 hsa-miR-1263:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.200E-3 4.603E-2
2.920E-1
1.000E0
 1 19
24 hsa-miR-26a-5p:Functional MTI Functional MTI miRTarbase 4.519E-3 4.603E-2
2.920E-1
1.000E0
 2 457
25 hsa-miR-661:Functional MTI Functional MTI miRTarbase 4.557E-3 4.603E-2
2.920E-1
1.000E0
 2 459
26 hsa-miR-664b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.641E-3 4.603E-2
2.920E-1
1.000E0
 1 21
27 hsa-miR-6890-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.713E-3 4.603E-2
2.920E-1
1.000E0
 2 467
28 hsa-miR-887-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.791E-3 4.603E-2
2.920E-1
1.000E0
 2 471
29 hsa-miR-125a-5p:mirSVR highEffct hsa-miR-125a-5p:mirSVR conserved highEffect-0.5 MicroRNA.org 4.791E-3 4.603E-2
2.920E-1
1.000E0
 2 471
30 hsa-miR-7703:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.851E-3 4.603E-2
2.920E-1
1.000E0
 2 474
31 hsa-miR-4284:mirSVR highEffct hsa-miR-4284:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.911E-3 4.603E-2
2.920E-1
1.000E0
 2 477
32 hsa-miR-597:mirSVR highEffct hsa-miR-597:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.971E-3 4.603E-2
2.920E-1
1.000E0
 2 480
33 hsa-miR-7160-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.112E-3 4.603E-2
2.920E-1
1.000E0
 2 487
34 hsa-miR-3147:mirSVR highEffct hsa-miR-3147:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.276E-3 4.603E-2
2.920E-1
1.000E0
 2 495
35 hsa-miR-4419b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.318E-3 4.603E-2
2.920E-1
1.000E0
 2 497
36 hsa-miR-4478:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.338E-3 4.603E-2
2.920E-1
1.000E0
 2 498
37 hsa-miR-3929:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.338E-3 4.603E-2
2.920E-1
1.000E0
 2 498
38 hsa-miR-1273c:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.523E-3 4.637E-2
2.941E-1
1.000E0
 1 25
Show 33 more annotations

17: Drug [Display Chart] 16 input genes in category / 4098 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID006450878 Etiocobalamin Stitch 5.692E-23 2.332E-19 2.075E-18 2.332E-19 12 177
2 CID000445722 AC1L9IGO Stitch 1.278E-15 2.620E-12 2.330E-11 5.239E-12 9 184
3 ctd:C082770 IMM 125 CTD 9.753E-13 1.332E-9 1.185E-8 3.997E-9 5 19
4 CID000002949 NSC-270916 Stitch 1.383E-11 1.417E-8 1.260E-7 5.666E-8 6 82
5 CID000126166 Factor Xiiib Stitch 2.705E-11 2.217E-8 1.972E-7 1.109E-7 5 35
6 ctd:C557505 3',4'-dimethoxy-alpha-naphthoflavone CTD 1.600E-10 1.093E-7 9.722E-7 6.557E-7 4 14
7 CID000000899 N-acetylhexosamine Stitch 3.489E-10 2.043E-7 1.817E-6 1.430E-6 8 472
8 CID011363491 2bxt Stitch 6.183E-10 3.167E-7 2.817E-6 2.534E-6 4 19
9 CID000446965 AC1L9KAW Stitch 9.432E-10 4.295E-7 3.820E-6 3.865E-6 6 164
10 CID006450018 hMCP Stitch 1.165E-9 4.776E-7 4.248E-6 4.776E-6 4 22
11 ctd:C076029 olanzapine CTD 1.600E-8 5.962E-6 5.304E-5 6.558E-5 5 121
12 ctd:D002793 Cholic Acids CTD 2.042E-8 6.973E-6 6.203E-5 8.367E-5 5 127
13 CID009547901 I-hu Stitch 4.637E-8 1.462E-5 1.300E-4 1.900E-4 3 11
14 CID000123895 N(omega)-hydroxy-L-arginine Stitch 1.605E-7 4.698E-5 4.179E-4 6.577E-4 4 72
15 ctd:C008435 methyldithiocarbamate CTD 3.141E-7 8.001E-5 7.117E-4 1.287E-3 4 85
16 ctd:D003613 Danazol CTD 3.192E-7 8.001E-5 7.117E-4 1.308E-3 3 20
17 CID000006329 methylamine Stitch 3.319E-7 8.001E-5 7.117E-4 1.360E-3 5 222
18 CID000077802 3-chlorobenzylamine Stitch 4.136E-7 9.416E-5 8.376E-4 1.695E-3 4 91
19 CID011953789 ferricytochrome Stitch 5.657E-7 1.220E-4 1.085E-3 2.318E-3 3 24
20 CID000002719 chloroquine Stitch 1.200E-6 2.459E-4 2.187E-3 4.918E-3 5 288
21 CID006438326 C 27 Stitch 1.380E-6 2.692E-4 2.395E-3 5.653E-3 2 3
22 CID006914586 E-SH Stitch 1.985E-6 3.698E-4 3.290E-3 8.136E-3 3 36
23 CID006398444 AC1O4QI2 Stitch 2.132E-6 3.798E-4 3.379E-3 8.735E-3 4 137
24 CID005494413 C1-N Stitch 2.758E-6 4.709E-4 4.189E-3 1.130E-2 2 4
25 CID000439641 AC1L97QT Stitch 3.421E-6 5.608E-4 4.989E-3 1.402E-2 3 43
26 CID000073050 HT-2 toxin Stitch 5.754E-6 9.068E-4 8.067E-3 2.358E-2 3 51
27 CID000020138 butenal Stitch 6.305E-6 9.569E-4 8.512E-3 2.584E-2 4 180
28 3934 UP Bendroflumethiazide [73-48-3]; Up 200; 9.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 9.373E-6 1.306E-3 1.162E-2 3.841E-2 4 199
29 CID000006557 isoprene Stitch 9.418E-6 1.306E-3 1.162E-2 3.859E-2 3 60
30 3752 UP Promazine hydrochloride [53-60-1]; Up 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 9.561E-6 1.306E-3 1.162E-2 3.918E-2 4 200
31 CID005326876 3-CB Stitch 1.285E-5 1.646E-3 1.464E-2
5.266E-2
 2 8
32 CID000128975 epirubicinol Stitch 1.285E-5 1.646E-3 1.464E-2
5.266E-2
 2 8
33 CID000004413 nafamostat mesilate Stitch 1.999E-5 2.285E-3 2.033E-2
8.191E-2
 3 77
34 CID000014055 cyanoacetylene Stitch 2.063E-5 2.285E-3 2.033E-2
8.456E-2
 2 10
35 CID000657149 IH-4 Stitch 2.063E-5 2.285E-3 2.033E-2
8.456E-2
 2 10
36 CID000003738 iotrolan Stitch 2.063E-5 2.285E-3 2.033E-2
8.456E-2
 2 10
37 CID000005167 IN 1-105 Stitch 2.063E-5 2.285E-3 2.033E-2
8.456E-2
 2 10
38 CID005287728 1zz2 Stitch 2.415E-5 2.604E-3 2.316E-2
9.895E-2
 3 82
39 ctd:C016310 cobra venom factor CTD 3.024E-5 3.177E-3 2.827E-2
1.239E-1
 2 12
40 CID005289130 phycoerythrobilin Stitch 3.572E-5 3.548E-3 3.156E-2
1.464E-1
 2 13
41 CID006438545 heme d(1 Stitch 3.572E-5 3.548E-3 3.156E-2
1.464E-1
 2 13
42 CID003002889 AC1MHEDK Stitch 3.636E-5 3.548E-3 3.156E-2
1.490E-1
 3 94
43 CID000101638 NSC523374 Stitch 5.489E-5 5.112E-3 4.548E-2
2.249E-1
 2 16
44 ctd:D064750 Rabeprazole CTD 5.489E-5 5.112E-3 4.548E-2
2.249E-1
 2 16
45 ctd:D028321 Plant Preparations CTD 5.951E-5 5.420E-3 4.821E-2
2.439E-1
 4 319
46 CID005359485 alternariol Stitch 6.218E-5 5.540E-3 4.928E-2
2.548E-1
 2 17
47 CID000001990 acetohydroxamic acid Stitch 6.467E-5 5.639E-3
5.016E-2
2.650E-1
 3 114
48 CID012769075 4-methyl-2-(sulfanylmethyl)pentanamide Stitch 6.993E-5 5.970E-3
5.311E-2
2.866E-1
 2 18
49 ctd:C064276 pantoprazole CTD 8.677E-5 7.257E-3
6.455E-2
3.556E-1
 2 20
50 CID005288910 H type 2 Stitch 9.556E-5 7.555E-3
6.720E-2
3.916E-1
 3 130
Show 45 more annotations

18: Disease [Display Chart] 16 input genes in category / 747 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C2931788 Atypical Hemolytic Uremic Syndrome DisGeNET Curated 2.979E-15 2.225E-12 1.601E-11 2.225E-12 7 39
2 C0242383 Age related macular degeneration DisGeNET Curated 9.221E-14 3.444E-11 2.478E-10 6.888E-11 10 336
3 C4055342 C3 Glomerulonephritis DisGeNET BeFree 3.166E-12 7.884E-10 5.672E-9 2.365E-9 4 5
4 C0701807 Acute anterior uveitis DisGeNET BeFree 6.286E-10 1.174E-7 8.445E-7 4.695E-7 5 46
5 C3463916 Complement Factor I (C3 inactivator) deficiency DisGeNET Curated 7.897E-10 1.180E-7 8.488E-7 5.899E-7 3 3
6 C0272242 Complement deficiency disease DisGeNET Curated 1.145E-9 1.426E-7 1.026E-6 8.554E-7 4 16
7 C1970263 Increased susceptibility to Neisseria meningitidis infections DisGeNET Curated 3.157E-9 3.369E-7 2.424E-6 2.358E-6 3 4
8 C0019243 Angioedemas, Hereditary DisGeNET Curated 4.586E-9 4.282E-7 3.081E-6 3.426E-6 4 22
9 OMIN:235400 HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1; AHUS1 OMIM 7.888E-9 5.892E-7 4.239E-6 5.892E-6 3 5
10 C0268743 Membranoproliferative Glomerulonephritis, Type II DisGeNET Curated 7.888E-9 5.892E-7 4.239E-6 5.892E-6 3 5
11 C0017658 Glomerulonephritis DisGeNET Curated 9.608E-9 6.525E-7 4.694E-6 7.177E-6 6 172
12 C0853888 Hypocomplementaemia DisGeNET BeFree 2.757E-8 1.584E-6 1.140E-5 2.060E-5 3 7
13 C3150275 COMPLEMENT COMPONENT 2 DEFICIENCY DisGeNET Curated 2.757E-8 1.584E-6 1.140E-5 2.060E-5 3 7
14 C2717961 Thrombotic Microangiopathies DisGeNET Curated 3.257E-8 1.738E-6 1.250E-5 2.433E-5 4 35
15 C0162739 HELLP Syndrome DisGeNET Curated 5.105E-8 2.542E-6 1.829E-5 3.813E-5 4 39
16 C0025303 Meningococcal Infections DisGeNET Curated 1.307E-7 6.103E-6 4.390E-5 9.765E-5 4 49
17 C0019061 Hemolytic-Uremic Syndrome DisGeNET Curated 2.097E-7 9.213E-6 6.628E-5 1.566E-4 4 55
18 C0001733 Afibrinogenemia DisGeNET Curated 2.856E-7 1.185E-5 8.525E-5 2.133E-4 3 14
19 C0042165 Anterior uveitis DisGeNET BeFree 3.567E-7 1.403E-5 1.009E-4 2.665E-4 3 15
20 C0024790 Paroxysmal nocturnal hemoglobinuria DisGeNET Curated 4.679E-7 1.747E-5 1.257E-4 3.495E-4 4 67
21 C1837512 Decreased serum C3 DisGeNET Curated 9.140E-7 2.731E-5 1.965E-4 6.827E-4 2 2
22 C4021636 Decreased serum complement factor B DisGeNET Curated 9.140E-7 2.731E-5 1.965E-4 6.827E-4 2 2
23 C1268937 Diarrhea-negative hemolytic uremic syndrome DisGeNET BeFree 9.140E-7 2.731E-5 1.965E-4 6.827E-4 2 2
24 C1969222 Decreased serum complement factor H DisGeNET Curated 9.140E-7 2.731E-5 1.965E-4 6.827E-4 2 2
25 cv:CN180565 Age-related macular degeneration 14 Clinical Variations 9.140E-7 2.731E-5 1.965E-4 6.827E-4 2 2
26 C0268742 Membranoproliferative Glomerulonephritis, Type I DisGeNET Curated 2.740E-6 7.757E-5 5.580E-4 2.047E-3 2 3
27 C0036690 Septicemia DisGeNET Curated 2.804E-6 7.757E-5 5.580E-4 2.094E-3 6 450
28 C0024530 Malaria DisGeNET Curated 3.606E-6 9.619E-5 6.920E-4 2.693E-3 6 470
29 C0243026 Sepsis DisGeNET Curated 5.035E-6 1.240E-4 8.920E-4 3.761E-3 6 498
30 C3151085 MASP2 Deficiency DisGeNET Curated 5.478E-6 1.240E-4 8.920E-4 4.092E-3 2 4
31 C1704430 Urinary Schistosomiasis DisGeNET BeFree 5.478E-6 1.240E-4 8.920E-4 4.092E-3 2 4
32 C0398777 Complement Factor H Deficiency DisGeNET Curated 5.478E-6 1.240E-4 8.920E-4 4.092E-3 2 4
33 C1832174 DOYNE HONEYCOMB RETINAL DYSTROPHY DisGeNET Curated 5.478E-6 1.240E-4 8.920E-4 4.092E-3 2 4
34 C0027697 Nephritis DisGeNET Curated 8.223E-6 1.807E-4 1.300E-3 6.143E-3 4 137
35 C0034155 Purpura, Thrombotic Thrombocytopenic DisGeNET Curated 8.856E-6 1.890E-4 1.360E-3 6.615E-3 3 42
36 C2749604 HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1 DisGeNET Curated 9.124E-6 1.893E-4 1.362E-3 6.816E-3 2 5
37 C1260959 Drusen DisGeNET Curated 1.020E-5 2.060E-4 1.482E-3 7.622E-3 3 44
38 C2316810 Chronic kidney disease stage 5 DisGeNET Curated 1.252E-5 2.461E-4 1.771E-3 9.353E-3 5 331
39 C0024301 Lymphoma, Follicular DisGeNET Curated 1.617E-5 3.098E-4 2.229E-3 1.208E-2 5 349
40 C0022661 Kidney Failure, Chronic DisGeNET Curated 1.854E-5 3.462E-4 2.490E-3 1.385E-2 5 359
41 C0242966 Systemic Inflammatory Response Syndrome DisGeNET BeFree 2.357E-5 4.295E-4 3.090E-3 1.761E-2 3 58
42 OMIN:603075 MACULAR DEGENERATION, AGE-RELATED, 1; ARMD1 OMIM 3.277E-5 5.564E-4 4.002E-3 2.448E-2 2 9
43 C1268936 Diarrhea-associated hemolytic uremic syndrome DisGeNET BeFree 3.277E-5 5.564E-4 4.002E-3 2.448E-2 2 9
44 C1864205 Macular Degeneration, Age-Related, 1 DisGeNET Curated 3.277E-5 5.564E-4 4.002E-3 2.448E-2 2 9
45 C0011884 Diabetic Retinopathy DisGeNET Curated 3.577E-5 5.938E-4 4.272E-3 2.672E-2 4 199
46 C3873491 Invasive meningococcal disease DisGeNET BeFree 4.094E-5 6.648E-4 4.783E-3 3.058E-2 2 10
47 C0020540 Malignant Hypertension DisGeNET Curated 5.001E-5 7.648E-4 5.502E-3 3.736E-2 2 11
48 C0206750 Coronavirus Infections DisGeNET BeFree 5.001E-5 7.648E-4 5.502E-3 3.736E-2 2 11
49 C0017661 IGA Glomerulonephritis DisGeNET Curated 5.017E-5 7.648E-4 5.502E-3 3.747E-2 4 217
50 C0333186 Restenosis DisGeNET BeFree 5.199E-5 7.768E-4 5.588E-3 3.884E-2 4 219
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