Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc255_5, positive side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 5 input genes in category / 23 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070851 growth factor receptor binding 5.744E-4 8.211E-3 3.066E-2 1.321E-2 2 143
2 GO:0008083 growth factor activity 7.728E-4 8.211E-3 3.066E-2 1.778E-2 2 166
3 GO:0005539 glycosaminoglycan binding 1.339E-3 8.211E-3 3.066E-2 3.081E-2 2 219
4 GO:0043237 laminin-1 binding 1.874E-3 8.211E-3 3.066E-2 4.311E-2 1 7
5 GO:0005113 patched binding 2.142E-3 8.211E-3 3.066E-2 4.926E-2 1 8
6 GO:0016015 morphogen activity 2.142E-3 8.211E-3 3.066E-2 4.926E-2 1 8
7 GO:0031005 filamin binding 4.280E-3 1.307E-2 4.882E-2
9.844E-2
 1 16
8 GO:0005161 platelet-derived growth factor receptor binding 4.547E-3 1.307E-2 4.882E-2
1.046E-1
 1 17
9 GO:0005104 fibroblast growth factor receptor binding 7.481E-3 1.912E-2
7.139E-2
1.721E-1
 1 28
10 GO:0043236 laminin binding 8.546E-3 1.965E-2
7.340E-2
1.965E-1
 1 32
11 GO:0016303 1-phosphatidylinositol-3-kinase activity 1.147E-2 2.398E-2
8.956E-2
2.638E-1
 1 43
12 GO:0050840 extracellular matrix binding 1.492E-2 2.711E-2
1.013E-1
3.431E-1
 1 56
13 GO:0052742 phosphatidylinositol kinase activity 1.545E-2 2.711E-2
1.013E-1
3.553E-1
 1 58
14 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1.650E-2 2.711E-2
1.013E-1
3.796E-1
 1 62
15 GO:0052813 phosphatidylinositol bisphosphate kinase activity 1.915E-2 2.804E-2
1.047E-1
4.403E-1
 1 72
16 GO:0035004 phosphatidylinositol 3-kinase activity 2.046E-2 2.804E-2
1.047E-1
4.707E-1
 1 77
17 GO:0051219 phosphoprotein binding 2.073E-2 2.804E-2
1.047E-1
4.767E-1
 1 78
18 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3.903E-2 4.988E-2
1.863E-1
8.978E-1
 1 148
Show 13 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 650 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0051781 positive regulation of cell division 4.113E-6 2.673E-3 1.886E-2 2.673E-3 3 140
2 GO:0048643 positive regulation of skeletal muscle tissue development 1.869E-5 5.817E-3 4.104E-2 1.215E-2 2 26
3 GO:0035116 embryonic hindlimb morphogenesis 3.224E-5 5.817E-3 4.104E-2 2.096E-2 2 34
4 GO:0051302 regulation of cell division 3.690E-5 5.817E-3 4.104E-2 2.398E-2 3 291
5 GO:0035137 hindlimb morphogenesis 5.431E-5 5.817E-3 4.104E-2 3.530E-2 2 44
6 GO:2000179 positive regulation of neural precursor cell proliferation 7.904E-5 5.817E-3 4.104E-2
5.137E-2
 2 53
7 GO:0048641 regulation of skeletal muscle tissue development 8.207E-5 5.817E-3 4.104E-2
5.334E-2
 2 54
8 GO:0010463 mesenchymal cell proliferation 8.207E-5 5.817E-3 4.104E-2
5.334E-2
 2 54
9 GO:0045844 positive regulation of striated muscle tissue development 1.155E-4 5.817E-3 4.104E-2
7.507E-2
 2 64
10 GO:0048636 positive regulation of muscle organ development 1.155E-4 5.817E-3 4.104E-2
7.507E-2
 2 64
11 GO:1901863 positive regulation of muscle tissue development 1.191E-4 5.817E-3 4.104E-2
7.744E-2
 2 65
12 GO:0045445 myoblast differentiation 2.138E-4 5.817E-3 4.104E-2
1.390E-1
 2 87
13 GO:0001708 cell fate specification 2.237E-4 5.817E-3 4.104E-2
1.454E-1
 2 89
14 GO:0042475 odontogenesis of dentin-containing tooth 2.391E-4 5.817E-3 4.104E-2
1.554E-1
 2 92
15 GO:0051149 positive regulation of muscle cell differentiation 2.549E-4 5.817E-3 4.104E-2
1.657E-1
 2 95
16 GO:2000177 regulation of neural precursor cell proliferation 2.549E-4 5.817E-3 4.104E-2
1.657E-1
 2 95
17 GO:0007502 digestive tract mesoderm development 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
18 GO:2000062 negative regulation of ureter smooth muscle cell differentiation 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
19 GO:2000358 positive regulation of kidney smooth muscle cell differentiation 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
20 GO:0061189 positive regulation of sclerotome development 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
21 GO:0060783 mesenchymal smoothened signaling pathway involved in prostate gland development 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
22 GO:0060781 mesenchymal cell proliferation involved in prostate gland development 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
23 GO:1904530 negative regulation of actin filament binding 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
24 GO:0060782 regulation of mesenchymal cell proliferation involved in prostate gland development 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
25 GO:0061190 regulation of sclerotome development 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
26 GO:1904617 negative regulation of actin binding 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
27 GO:2000063 positive regulation of ureter smooth muscle cell differentiation 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
28 GO:2000357 negative regulation of kidney smooth muscle cell differentiation 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
29 GO:2000061 regulation of ureter smooth muscle cell differentiation 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
30 GO:2000356 regulation of kidney smooth muscle cell differentiation 2.685E-4 5.817E-3 4.104E-2
1.745E-1
 1 1
31 GO:0014902 myotube differentiation 4.271E-4 7.755E-3
5.471E-2
2.776E-1
 2 123
32 GO:0016202 regulation of striated muscle tissue development 4.411E-4 7.755E-3
5.471E-2
2.867E-1
 2 125
33 GO:0048634 regulation of muscle organ development 4.553E-4 7.755E-3
5.471E-2
2.959E-1
 2 127
34 GO:1901861 regulation of muscle tissue development 4.624E-4 7.755E-3
5.471E-2
3.006E-1
 2 128
35 GO:0042476 odontogenesis 4.697E-4 7.755E-3
5.471E-2
3.053E-1
 2 129
36 GO:0007224 smoothened signaling pathway 4.770E-4 7.755E-3
5.471E-2
3.100E-1
 2 130
37 GO:1904616 regulation of actin binding 5.369E-4 7.755E-3
5.471E-2
3.490E-1
 1 2
38 GO:0072195 kidney smooth muscle cell differentiation 5.369E-4 7.755E-3
5.471E-2
3.490E-1
 1 2
39 GO:0009949 polarity specification of anterior/posterior axis 5.369E-4 7.755E-3
5.471E-2
3.490E-1
 1 2
40 GO:0060516 primary prostatic bud elongation 5.369E-4 7.755E-3
5.471E-2
3.490E-1
 1 2
41 GO:0060458 right lung development 5.369E-4 7.755E-3
5.471E-2
3.490E-1
 1 2
42 GO:0046534 positive regulation of photoreceptor cell differentiation 5.369E-4 7.755E-3
5.471E-2
3.490E-1
 1 2
43 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development 5.369E-4 7.755E-3
5.471E-2
3.490E-1
 1 2
44 GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development 5.369E-4 7.755E-3
5.471E-2
3.490E-1
 1 2
45 GO:1904529 regulation of actin filament binding 5.369E-4 7.755E-3
5.471E-2
3.490E-1
 1 2
46 GO:0030326 embryonic limb morphogenesis 5.767E-4 7.976E-3
5.627E-2
3.749E-1
 2 143
47 GO:0035113 embryonic appendage morphogenesis 5.767E-4 7.976E-3
5.627E-2
3.749E-1
 2 143
48 GO:0048565 digestive tract development 6.343E-4 8.308E-3
5.862E-2
4.123E-1
 2 150
49 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 6.343E-4 8.308E-3
5.862E-2
4.123E-1
 2 150
50 GO:0055123 digestive system development 7.667E-4 8.308E-3
5.862E-2
4.984E-1
 2 165
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 6 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005788 endoplasmic reticulum lumen 1.149E-3 6.892E-3 1.689E-2 6.892E-3 2 207
2 GO:0031012 extracellular matrix 5.167E-3 1.550E-2 3.798E-2 3.100E-2 2 444

4: Human Phenotype [Display Chart] 3 input genes in category / 321 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001360 Holoprosencephaly 4.755E-4 4.091E-2
2.598E-1
1.526E-1
 2 60
2 HP:0012806 Proboscis 6.373E-4 4.091E-2
2.598E-1
2.046E-1
 1 1
3 HP:0000601 Hypotelorism 1.071E-3 4.091E-2
2.598E-1
3.439E-1
 2 90
4 HP:0010642 Midnasal atresia or stenosis 1.274E-3 4.091E-2
2.598E-1
4.091E-1
 1 2
5 HP:0010640 Abnormality of the nasal cavity 1.274E-3 4.091E-2
2.598E-1
4.091E-1
 1 2
6 HP:0006088 1-5 finger complete cutaneous syndactyly 1.274E-3 4.091E-2
2.598E-1
4.091E-1
 1 2
7 HP:0010503 Fibular duplication 1.274E-3 4.091E-2
2.598E-1
4.091E-1
 1 2
8 HP:0010641 Abnormality of the midnasal cavity 1.274E-3 4.091E-2
2.598E-1
4.091E-1
 1 2
9 HP:0010644 Midnasal stenosis 1.274E-3 4.091E-2
2.598E-1
4.091E-1
 1 2
10 HP:0010708 1-5 finger syndactyly 1.274E-3 4.091E-2
2.598E-1
4.091E-1
 1 2
11 HP:0100789 Torus palatinus 1.911E-3 4.382E-2
2.783E-1
6.135E-1
 1 3
12 HP:0002708 Prominent median palatal raphe 1.911E-3 4.382E-2
2.783E-1
6.135E-1
 1 3
13 HP:0001501 6 metacarpals 1.911E-3 4.382E-2
2.783E-1
6.135E-1
 1 3
14 HP:0005917 Supernumerary metacarpal bones 1.911E-3 4.382E-2
2.783E-1
6.135E-1
 1 3
Show 9 more annotations

5: Mouse Phenotype [Display Chart] 5 input genes in category / 702 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0009891 abnormal palate bone morphology 1.257E-6 5.808E-4 4.142E-3 8.825E-4 3 53
2 MP:0002239 abnormal nasal septum morphology 1.655E-6 5.808E-4 4.142E-3 1.162E-3 3 58
3 MP:0012256 abnormal philtrum morphology 2.796E-6 6.542E-4 4.666E-3 1.963E-3 2 6
4 MP:0002235 abnormal external nares morphology 5.217E-6 9.156E-4 6.530E-3 3.662E-3 2 8
5 MP:0030197 small nasal septum 1.024E-5 1.438E-3 1.026E-2 7.190E-3 2 11
6 MP:0009655 abnormal secondary palate development 1.455E-5 1.524E-3 1.087E-2 1.022E-2 3 119
7 MP:0009653 abnormal palate development 1.647E-5 1.524E-3 1.087E-2 1.156E-2 3 124
8 MP:0003756 abnormal hard palate morphology 1.770E-5 1.524E-3 1.087E-2 1.242E-2 3 127
9 MP:0004276 abnormal medial ganglionic eminence morphology 1.954E-5 1.524E-3 1.087E-2 1.372E-2 2 15
10 MP:0006197 ocular hypotelorism 2.232E-5 1.567E-3 1.118E-2 1.567E-2 2 16
11 MP:0006290 proboscis 2.530E-5 1.614E-3 1.151E-2 1.776E-2 2 17
12 MP:0009890 cleft secondary palate 3.408E-5 1.907E-3 1.360E-2 2.393E-2 3 158
13 MP:0009883 palatal shelf hypoplasia 3.532E-5 1.907E-3 1.360E-2 2.479E-2 2 20
14 MP:0002233 abnormal nose morphology 4.550E-5 2.249E-3 1.604E-2 3.194E-2 3 174
15 MP:0013550 abnormal secondary palate morphology 5.119E-5 2.249E-3 1.604E-2 3.594E-2 3 181
16 MP:0004277 abnormal lateral ganglionic eminence morphology 5.127E-5 2.249E-3 1.604E-2 3.599E-2 2 24
17 MP:0000087 absent mandible 9.199E-5 3.799E-3 2.709E-2
6.458E-2
 2 32
18 MP:0009886 failure of palatal shelf elevation 1.103E-4 4.301E-3 3.068E-2
7.742E-2
 2 35
19 MP:0004538 abnormal maxillary shelf morphology 1.168E-4 4.314E-3 3.076E-2
8.196E-2
 2 36
20 MP:0030268 agnathia 1.518E-4 5.329E-3 3.800E-2
1.066E-1
 2 41
21 MP:0012523 abnormal upper lip morphology 1.914E-4 6.365E-3 4.540E-2
1.344E-1
 2 46
22 MP:0009885 abnormal palatal shelf elevation 2.086E-4 6.365E-3 4.540E-2
1.464E-1
 2 48
23 MP:0004620 cervical vertebral fusion 2.086E-4 6.365E-3 4.540E-2
1.464E-1
 2 48
24 MP:0002820 abnormal premaxilla morphology 2.356E-4 6.731E-3 4.800E-2
1.654E-1
 2 51
25 MP:0009888 palatal shelves fail to meet at midline 2.450E-4 6.731E-3 4.800E-2
1.720E-1
 2 52
26 MP:0000111 cleft palate 2.493E-4 6.731E-3 4.800E-2
1.750E-1
 3 308
27 MP:0003769 abnormal lip morphology 2.643E-4 6.871E-3 4.900E-2
1.855E-1
 2 54
28 MP:0000565 oligodactyly 2.843E-4 7.127E-3
5.083E-2
1.996E-1
 2 56
29 MP:0005157 holoprosencephaly 3.157E-4 7.641E-3
5.450E-2
2.216E-1
 2 59
30 MP:0003755 abnormal palate morphology 3.341E-4 7.817E-3
5.575E-2
2.345E-1
 3 340
31 MP:0004274 abnormal embryonic/fetal subventricular zone morphology 3.487E-4 7.896E-3
5.631E-2
2.448E-1
 2 62
32 MP:0000141 abnormal vertebral body morphology 4.073E-4 8.935E-3
6.372E-2
2.859E-1
 2 67
33 MP:0000149 abnormal scapula morphology 4.574E-4 9.161E-3
6.534E-2
3.211E-1
 2 71
34 MP:0030218 piriform aperture stenosis 4.829E-4 9.161E-3
6.534E-2
3.390E-1
 1 1
35 MP:0030202 nasal septum cartilage hypoplasia 4.829E-4 9.161E-3
6.534E-2
3.390E-1
 1 1
36 MP:0030217 abnormal piriform aperture morphology 4.829E-4 9.161E-3
6.534E-2
3.390E-1
 1 1
37 MP:0030201 absent nasal septum cartilage 4.829E-4 9.161E-3
6.534E-2
3.390E-1
 1 1
38 MP:0009887 abnormal palatal shelf fusion at midline 4.969E-4 9.179E-3
6.546E-2
3.488E-1
 2 74
39 MP:0005225 abnormal vertebrae development 5.104E-4 9.187E-3
6.552E-2
3.583E-1
 2 75
40 MP:0004173 abnormal intervertebral disk morphology 6.100E-4 1.071E-2
7.635E-2
4.282E-1
 2 82
41 MP:0030385 absent facial bone 6.553E-4 1.122E-2
8.002E-2
4.600E-1
 2 85
42 MP:0003935 abnormal craniofacial development 6.818E-4 1.140E-2
8.127E-2
4.786E-1
 3 433
43 MP:0030877 abnormal symphysis morphology 7.023E-4 1.147E-2
8.177E-2
4.930E-1
 2 88
44 MP:0011495 abnormal head shape 7.345E-4 1.172E-2
8.357E-2
5.156E-1
 2 90
45 MP:0013545 cleft hard palate 7.841E-4 1.223E-2
8.723E-2
5.504E-1
 2 93
46 MP:0003054 spina bifida 8.353E-4 1.232E-2
8.789E-2
5.864E-1
 2 96
47 MP:0004948 abnormal neuronal precursor proliferation 9.060E-4 1.232E-2
8.789E-2
6.360E-1
 2 100
48 MP:0001299 abnormal eye distance/ position 9.241E-4 1.232E-2
8.789E-2
6.487E-1
 2 101
49 MP:0013788 external nares atresia 9.655E-4 1.232E-2
8.789E-2
6.778E-1
 1 2
50 MP:0012257 absent philtrum 9.655E-4 1.232E-2
8.789E-2
6.778E-1
 1 2
Show 45 more annotations

6: Domain [Display Chart] 5 input genes in category / 57 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR028239 FGF4 InterPro 2.669E-4 2.684E-3 1.242E-2 1.521E-2 1 1
2 IPR030624 CRMP1 InterPro 2.669E-4 2.684E-3 1.242E-2 1.521E-2 1 1
3 IPR029817 PDGF-C InterPro 2.669E-4 2.684E-3 1.242E-2 1.521E-2 1 1
4 IPR032983 CDO InterPro 2.669E-4 2.684E-3 1.242E-2 1.521E-2 1 1
5 PS50817 INTEIN N TER PROSITE 5.337E-4 2.684E-3 1.242E-2 3.042E-2 1 2
6 IPR006141 Intein N InterPro 5.337E-4 2.684E-3 1.242E-2 3.042E-2 1 2
7 SM00306 HintN SMART 8.005E-4 2.684E-3 1.242E-2 4.563E-2 1 3
8 IPR009045 Hedgehog sig/DD-Pept Zn-bd dom InterPro 8.005E-4 2.684E-3 1.242E-2 4.563E-2 1 3
9 3.30.1380.10 - Gene3D 8.005E-4 2.684E-3 1.242E-2 4.563E-2 1 3
10 SM00305 HintC SMART 8.005E-4 2.684E-3 1.242E-2 4.563E-2 1 3
11 PF01079 Hint Pfam 8.005E-4 2.684E-3 1.242E-2 4.563E-2 1 3
12 IPR001767 Hint dom InterPro 8.005E-4 2.684E-3 1.242E-2 4.563E-2 1 3
13 IPR003586 Hint dom C InterPro 8.005E-4 2.684E-3 1.242E-2 4.563E-2 1 3
14 IPR001657 Hedgehog InterPro 8.005E-4 2.684E-3 1.242E-2 4.563E-2 1 3
15 PF01085 HH signal Pfam 8.005E-4 2.684E-3 1.242E-2 4.563E-2 1 3
16 IPR003587 Hint dom N InterPro 8.005E-4 2.684E-3 1.242E-2 4.563E-2 1 3
17 IPR000320 Hedgehog signalling dom InterPro 8.005E-4 2.684E-3 1.242E-2 4.563E-2 1 3
18 2.170.16.10 - Gene3D 1.067E-3 3.202E-3 1.482E-2
6.083E-2
 1 4
19 IPR028992 Hedgehog/Intein dom InterPro 1.067E-3 3.202E-3 1.482E-2
6.083E-2
 1 4
20 IPR009051 Helical ferredxn InterPro 1.334E-3 3.801E-3 1.760E-2
7.603E-2
 1 5
21 IPR011778 Hydantoinase/dihydroPyrase InterPro 1.600E-3 4.344E-3 2.011E-2
9.122E-2
 1 6
22 2.30.40.10 - Gene3D 2.133E-3 5.066E-3 2.345E-2
1.216E-1
 1 8
23 PF00341 PDGF Pfam 2.400E-3 5.066E-3 2.345E-2
1.368E-1
 1 9
24 SM00141 PDGF SMART 2.400E-3 5.066E-3 2.345E-2
1.368E-1
 1 9
25 IPR000072 PDGF/VEGF dom InterPro 2.400E-3 5.066E-3 2.345E-2
1.368E-1
 1 9
26 PS50278 PDGF 2 PROSITE 2.400E-3 5.066E-3 2.345E-2
1.368E-1
 1 9
27 PS00249 PDGF 1 PROSITE 2.400E-3 5.066E-3 2.345E-2
1.368E-1
 1 9
28 PF01979 Amidohydro 1 Pfam 2.666E-3 5.241E-3 2.426E-2
1.520E-1
 1 10
29 IPR011059 Metal-dep hydrolase composite InterPro 2.666E-3 5.241E-3 2.426E-2
1.520E-1
 1 10
30 IPR006680 Amidohydro-rel InterPro 2.933E-3 5.572E-3 2.579E-2
1.672E-1
 1 11
31 PF00167 FGF Pfam 5.858E-3 9.821E-3 4.546E-2
3.339E-1
 1 22
32 IPR002209 Fibroblast GF fam InterPro 5.858E-3 9.821E-3 4.546E-2
3.339E-1
 1 22
33 SM00442 FGF SMART 5.858E-3 9.821E-3 4.546E-2
3.339E-1
 1 22
34 PS00247 HBGF FGF PROSITE 5.858E-3 9.821E-3 4.546E-2
3.339E-1
 1 22
35 IPR028142 IL-1 fam/FGF fam InterPro 6.124E-3 9.973E-3 4.617E-2
3.491E-1
 1 23
36 IPR032466 Metal Hydrolase InterPro 6.389E-3 1.012E-2 4.683E-2
3.642E-1
 1 24
37 IPR008996 Cytokine IL1-like InterPro 9.572E-3 1.475E-2
6.826E-2
5.456E-1
 1 36
38 PF00431 CUB Pfam 1.301E-2 1.940E-2
8.981E-2
7.416E-1
 1 49
39 SM00042 CUB SMART 1.327E-2 1.940E-2
8.981E-2
7.566E-1
 1 50
40 2.60.120.290 - Gene3D 1.380E-2 1.956E-2
9.052E-2
7.867E-1
 1 52
41 PS01180 CUB PROSITE 1.407E-2 1.956E-2
9.052E-2
8.018E-1
 1 53
42 IPR000859 CUB dom InterPro 1.512E-2 2.052E-2
9.500E-2
8.619E-1
 1 57
43 IPR029034 Cystine-knot cytokine InterPro 1.776E-2 2.300E-2
1.065E-1
1.000E0
 1 67
44 2.10.90.10 - Gene3D 1.776E-2 2.300E-2
1.065E-1
1.000E0
 1 67
Show 39 more annotations

7: Pathway [Display Chart] 5 input genes in category / 147 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269641 Ligand-receptor interactions BioSystems: REACTOME 3.610E-6 5.306E-4 2.956E-3 5.306E-4 2 8
2 1269642 Activation of SMO BioSystems: REACTOME 1.969E-5 1.447E-3 8.064E-3 2.895E-3 2 18
3 137950 Signaling events mediated by the Hedgehog family BioSystems: Pathway Interaction Database 2.971E-5 1.456E-3 8.111E-3 4.368E-3 2 22
4 83063 Hedgehog signaling pathway BioSystems: KEGG 1.385E-4 5.089E-3 2.835E-2 2.036E-2 2 47
5 M5883 Genes encoding secreted soluble factors MSigDB C2 BIOCARTA (v6.0) 2.007E-4 5.899E-3 3.287E-2 2.950E-2 3 344
6 83114 Melanoma BioSystems: KEGG 2.995E-4 7.337E-3 4.088E-2 4.402E-2 2 69
7 1269640 Hedgehog 'on' state BioSystems: REACTOME 4.983E-4 1.046E-2
5.830E-2
7.325E-2
 2 89
8 PW:0000321 altered Hedgehog signaling Pathway Ontology 8.031E-4 1.312E-2
7.308E-2
1.181E-1
 1 2
9 PW:0000122 Hedgehog signaling Pathway Ontology 8.031E-4 1.312E-2
7.308E-2
1.181E-1
 1 2
10 1339127 HHAT G278V abrogates palmitoylation of Hh-Np BioSystems: REACTOME 1.204E-3 1.664E-2
9.272E-2
1.771E-1
 1 3
11 1269633 Signaling by Hedgehog BioSystems: REACTOME 1.245E-3 1.664E-2
9.272E-2
1.831E-1
 2 141
12 868086 Rap1 signaling pathway BioSystems: KEGG 2.738E-3 2.553E-2
1.422E-1
4.025E-1
 2 210
13 83089 Regulation of actin cytoskeleton BioSystems: KEGG 2.790E-3 2.553E-2
1.422E-1
4.101E-1
 2 212
14 868085 Ras signaling pathway BioSystems: KEGG 3.192E-3 2.553E-2
1.422E-1
4.692E-1
 2 227
15 1269635 Release of Hh-Np from the secreting cell BioSystems: REACTOME 3.209E-3 2.553E-2
1.422E-1
4.718E-1
 1 8
16 138084 Glypican 3 network BioSystems: Pathway Interaction Database 3.209E-3 2.553E-2
1.422E-1
4.718E-1
 1 8
17 1268868 Signaling by activated point mutants of FGFR1 BioSystems: REACTOME 4.411E-3 2.553E-2
1.422E-1
6.484E-1
 1 11
18 M13022 Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle MSigDB C2 BIOCARTA (v6.0) 4.411E-3 2.553E-2
1.422E-1
6.484E-1
 1 11
19 1269390 FGFR1c ligand binding and activation BioSystems: REACTOME 4.811E-3 2.553E-2
1.422E-1
7.072E-1
 1 12
20 1268875 Signaling by activated point mutants of FGFR3 BioSystems: REACTOME 4.811E-3 2.553E-2
1.422E-1
7.072E-1
 1 12
21 1268874 FGFR3 mutant receptor activation BioSystems: REACTOME 4.811E-3 2.553E-2
1.422E-1
7.072E-1
 1 12
22 1269415 Phospholipase C-mediated cascade; FGFR3 BioSystems: REACTOME 5.211E-3 2.553E-2
1.422E-1
7.660E-1
 1 13
23 1269410 FGFR3 ligand binding and activation BioSystems: REACTOME 5.211E-3 2.553E-2
1.422E-1
7.660E-1
 1 13
24 1383021 FGFRL1 modulation of FGFR1 signaling BioSystems: REACTOME 5.211E-3 2.553E-2
1.422E-1
7.660E-1
 1 13
25 1269412 FGFR3c ligand binding and activation BioSystems: REACTOME 5.211E-3 2.553E-2
1.422E-1
7.660E-1
 1 13
26 1269402 FGFR2c ligand binding and activation BioSystems: REACTOME 5.211E-3 2.553E-2
1.422E-1
7.660E-1
 1 13
27 1269420 FGFR4 ligand binding and activation BioSystems: REACTOME 5.611E-3 2.553E-2
1.422E-1
8.248E-1
 1 14
28 1269424 Phospholipase C-mediated cascade; FGFR4 BioSystems: REACTOME 6.011E-3 2.553E-2
1.422E-1
8.836E-1
 1 15
29 M11792 Sonic Hedgehog (Shh) Pathway MSigDB C2 BIOCARTA (v6.0) 6.410E-3 2.553E-2
1.422E-1
9.423E-1
 1 16
30 1269388 FGFR1 ligand binding and activation BioSystems: REACTOME 6.410E-3 2.553E-2
1.422E-1
9.423E-1
 1 16
31 1270310 CRMPs in Sema3A signaling BioSystems: REACTOME 6.410E-3 2.553E-2
1.422E-1
9.423E-1
 1 16
32 1269394 Phospholipase C-mediated cascade: FGFR1 BioSystems: REACTOME 6.410E-3 2.553E-2
1.422E-1
9.423E-1
 1 16
33 1268871 Activated point mutants of FGFR2 BioSystems: REACTOME 6.810E-3 2.553E-2
1.422E-1
1.000E0
 1 17
34 692234 PI3K-Akt signaling pathway BioSystems: KEGG 7.122E-3 2.553E-2
1.422E-1
1.000E0
 2 342
35 1269405 Phospholipase C-mediated cascade; FGFR2 BioSystems: REACTOME 7.209E-3 2.553E-2
1.422E-1
1.000E0
 1 18
36 1269416 SHC-mediated cascade:FGFR3 BioSystems: REACTOME 7.209E-3 2.553E-2
1.422E-1
1.000E0
 1 18
37 1269417 PI-3K cascade:FGFR3 BioSystems: REACTOME 7.209E-3 2.553E-2
1.422E-1
1.000E0
 1 18
38 P00025 Hedgehog signaling pathway PantherDB 7.608E-3 2.553E-2
1.422E-1
1.000E0
 1 19
39 P00007 Axon guidance mediated by semaphorins PantherDB 7.608E-3 2.553E-2
1.422E-1
1.000E0
 1 19
40 1269425 SHC-mediated cascade:FGFR4 BioSystems: REACTOME 8.008E-3 2.553E-2
1.422E-1
1.000E0
 1 20
41 1269426 PI-3K cascade:FGFR4 BioSystems: REACTOME 8.008E-3 2.553E-2
1.422E-1
1.000E0
 1 20
42 1269414 FRS-mediated FGFR3 signaling BioSystems: REACTOME 8.008E-3 2.553E-2
1.422E-1
1.000E0
 1 20
43 1269400 FGFR2 ligand binding and activation BioSystems: REACTOME 8.008E-3 2.553E-2
1.422E-1
1.000E0
 1 20
44 1269395 SHC-mediated cascade:FGFR1 BioSystems: REACTOME 8.407E-3 2.553E-2
1.422E-1
1.000E0
 1 21
45 1269396 PI-3K cascade:FGFR1 BioSystems: REACTOME 8.407E-3 2.553E-2
1.422E-1
1.000E0
 1 21
46 1268855 Diseases of signal transduction BioSystems: REACTOME 8.431E-3 2.553E-2
1.422E-1
1.000E0
 2 373
47 1269478 Signaling by PDGF BioSystems: REACTOME 8.696E-3 2.553E-2
1.422E-1
1.000E0
 2 379
48 1269423 FRS-mediated FGFR4 signaling BioSystems: REACTOME 8.806E-3 2.553E-2
1.422E-1
1.000E0
 1 22
49 1268873 Signaling by FGFR3 in disease BioSystems: REACTOME 8.806E-3 2.553E-2
1.422E-1
1.000E0
 1 22
50 1383047 Signaling by FGFR3 point mutants in cancer BioSystems: REACTOME 8.806E-3 2.553E-2
1.422E-1
1.000E0
 1 22
Show 45 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 3193 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 25117422 The Shh coreceptor Cdo is required for differentiation of midbrain dopaminergic neurons. Pubmed 1.371E-8 1.313E-5 1.136E-4 4.378E-5 2 2
2 27935818 Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia. Pubmed 1.371E-8 1.313E-5 1.136E-4 4.378E-5 2 2
3 18794898 The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Pubmed 1.371E-8 1.313E-5 1.136E-4 4.378E-5 2 2
4 15256670 The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Pubmed 4.113E-8 1.313E-5 1.136E-4 1.313E-4 2 3
5 17610861 Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb. Pubmed 4.113E-8 1.313E-5 1.136E-4 1.313E-4 2 3
6 9392510 Signalling networks regulating dental development. Pubmed 4.113E-8 1.313E-5 1.136E-4 1.313E-4 2 3
7 28441416 Ethanol itself is a holoprosencephaly-inducing teratogen. Pubmed 4.113E-8 1.313E-5 1.136E-4 1.313E-4 2 3
8 8922528 Spatial and temporal relationships between Shh, Fgf4, and Fgf8 gene expression at diverse signalling centers during mouse development. Pubmed 4.113E-8 1.313E-5 1.136E-4 1.313E-4 2 3
9 8792609 Ectopic expression of Fgf-4 in chimeric mouse embryos induces the expression of early markers of limb development in the lateral ridge. Pubmed 4.113E-8 1.313E-5 1.136E-4 1.313E-4 2 3
10 9630220 FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Pubmed 4.113E-8 1.313E-5 1.136E-4 1.313E-4 2 3
11 9073443 Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse. Pubmed 8.226E-8 1.382E-5 1.195E-4 2.627E-4 2 4
12 9256345 The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development. Pubmed 8.226E-8 1.382E-5 1.195E-4 2.627E-4 2 4
13 16586350 Molar tooth development in caspase-3 deficient mice. Pubmed 8.226E-8 1.382E-5 1.195E-4 2.627E-4 2 4
14 24244464 Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1. Pubmed 8.226E-8 1.382E-5 1.195E-4 2.627E-4 2 4
15 7915198 Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures. Pubmed 8.226E-8 1.382E-5 1.195E-4 2.627E-4 2 4
16 8660860 Morphological and molecular characterization of retinoic acid-induced limb duplications in mice. Pubmed 8.226E-8 1.382E-5 1.195E-4 2.627E-4 2 4
17 7885472 Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Pubmed 8.226E-8 1.382E-5 1.195E-4 2.627E-4 2 4
18 15198975 Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Pubmed 8.226E-8 1.382E-5 1.195E-4 2.627E-4 2 4
19 11430695 Retinoic acid specifically downregulates Fgf4 and inhibits posterior cell proliferation in the developing mouse autopod. Pubmed 8.226E-8 1.382E-5 1.195E-4 2.627E-4 2 4
20 9486790 The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot. Pubmed 1.371E-7 1.459E-5 1.262E-4 4.377E-4 2 5
21 26906632 A Shh coreceptor Cdo is required for efficient cardiomyogenesis of pluripotent stem cells. Pubmed 1.371E-7 1.459E-5 1.262E-4 4.377E-4 2 5
22 20709958 Patterning by heritage in mouse molar row development. Pubmed 1.371E-7 1.459E-5 1.262E-4 4.377E-4 2 5
23 23751077 Gadd45g regulates dental epithelial cell proliferation through p38 MAPK-mediated p21 expression. Pubmed 1.371E-7 1.459E-5 1.262E-4 4.377E-4 2 5
24 11101845 Fgf8 is required for outgrowth and patterning of the limbs. Pubmed 1.371E-7 1.459E-5 1.262E-4 4.377E-4 2 5
25 10021368 Identification of sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch. Pubmed 1.371E-7 1.459E-5 1.262E-4 4.377E-4 2 5
26 7635045 Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity. Pubmed 1.371E-7 1.459E-5 1.262E-4 4.377E-4 2 5
27 26042621 The enamel knot-like structure is eternally maintained in the apical bud of postnatal mouse incisors. Pubmed 1.371E-7 1.459E-5 1.262E-4 4.377E-4 2 5
28 20519495 All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. Pubmed 1.371E-7 1.459E-5 1.262E-4 4.377E-4 2 5
29 28694256 Multiple modes of Lrp4 function in modulation of Wnt/β-catenin signaling during tooth development. Pubmed 1.371E-7 1.459E-5 1.262E-4 4.377E-4 2 5
30 12455636 Unusual pattern of Sonic hedgehog expression in the polydactylous mouse mutant Hemimelic extra-toes. Pubmed 1.371E-7 1.459E-5 1.262E-4 4.377E-4 2 5
31 10662638 Normal limb development in conditional mutants of Fgf4. Pubmed 2.056E-7 1.601E-5 1.385E-4 6.566E-4 2 6
32 19439426 Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Pubmed 2.056E-7 1.601E-5 1.385E-4 6.566E-4 2 6
33 15677727 Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb. Pubmed 2.056E-7 1.601E-5 1.385E-4 6.566E-4 2 6
34 21762405 Expression and characterization of c-Myb in prenatal odontogenesis. Pubmed 2.056E-7 1.601E-5 1.385E-4 6.566E-4 2 6
35 11023871 Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis. Pubmed 2.056E-7 1.601E-5 1.385E-4 6.566E-4 2 6
36 16179481 Regulation of mammalian tooth cusp patterning by ectodin. Pubmed 2.056E-7 1.601E-5 1.385E-4 6.566E-4 2 6
37 25063195 Boc modifies the spectrum of holoprosencephaly in the absence of Gas1 function. Pubmed 2.056E-7 1.601E-5 1.385E-4 6.566E-4 2 6
38 7628698 A duplicated zone of polarizing activity in polydactylous mouse mutants. Pubmed 2.056E-7 1.601E-5 1.385E-4 6.566E-4 2 6
39 9425131 Sonic hedgehog is not required for polarising activity in the Doublefoot mutant mouse limb bud. Pubmed 2.056E-7 1.601E-5 1.385E-4 6.566E-4 2 6
40 12502739 FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Pubmed 2.056E-7 1.601E-5 1.385E-4 6.566E-4 2 6
41 21465622 Pleiotropic patterning response to activation of Shh signaling in the limb apical ectodermal ridge. Pubmed 2.056E-7 1.601E-5 1.385E-4 6.566E-4 2 6
42 8575323 The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5' HoxD genes during limb pattern formation. Pubmed 2.879E-7 1.894E-5 1.637E-4 9.191E-4 2 7
43 20053908 Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc. Pubmed 2.879E-7 1.894E-5 1.637E-4 9.191E-4 2 7
44 11850405 Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling. Pubmed 2.879E-7 1.894E-5 1.637E-4 9.191E-4 2 7
45 11180951 Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4. Pubmed 2.879E-7 1.894E-5 1.637E-4 9.191E-4 2 7
46 16647303 Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Pubmed 2.879E-7 1.894E-5 1.637E-4 9.191E-4 2 7
47 10534614 Disrupting the establishment of polarizing activity by teratogen exposure. Pubmed 2.879E-7 1.894E-5 1.637E-4 9.191E-4 2 7
48 9006074 Limb deformity proteins: role in mesodermal induction of the apical ectodermal ridge. Pubmed 2.879E-7 1.894E-5 1.637E-4 9.191E-4 2 7
49 20212115 Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Pubmed 3.838E-7 1.894E-5 1.637E-4 1.225E-3 2 8
50 10802662 Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Pubmed 3.838E-7 1.894E-5 1.637E-4 1.225E-3 2 8
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 145 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:BOC BOC interactions 4.207E-6 4.188E-4 2.327E-3 6.101E-4 2 12
2 int:CDON CDON interactions 5.800E-6 4.188E-4 2.327E-3 8.410E-4 2 14
3 int:SHH SHH interactions 8.665E-6 4.188E-4 2.327E-3 1.256E-3 2 17
4 int:HHIP HHIP interactions 1.412E-3 3.682E-2
2.047E-1
2.047E-1
 1 5
5 int:FGF4 FGF4 interactions 1.694E-3 3.682E-2
2.047E-1
2.456E-1
 1 6
6 int:CCL18 CCL18 interactions 1.976E-3 3.682E-2
2.047E-1
2.865E-1
 1 7
7 int:GAS1 GAS1 interactions 1.976E-3 3.682E-2
2.047E-1
2.865E-1
 1 7
8 int:PTCH2 PTCH2 interactions 2.258E-3 3.682E-2
2.047E-1
3.274E-1
 1 8
9 int:IL33 IL33 interactions 2.540E-3 3.682E-2
2.047E-1
3.682E-1
 1 9
10 int:PDGFC PDGFC interactions 2.540E-3 3.682E-2
2.047E-1
3.682E-1
 1 9
11 int:NEO1 NEO1 interactions 2.822E-3 3.719E-2
2.067E-1
4.091E-1
 1 10
12 int:L3MBTL4 L3MBTL4 interactions 3.103E-3 3.750E-2
2.084E-1
4.500E-1
 1 11
13 int:CDH15 CDH15 interactions 3.385E-3 3.776E-2
2.098E-1
4.908E-1
 1 12
14 int:MRPS12 MRPS12 interactions 3.948E-3 3.833E-2
2.130E-1
5.725E-1
 1 14
15 int:NAT9 NAT9 interactions 4.230E-3 3.833E-2
2.130E-1
6.133E-1
 1 15
16 int:RGL2 RGL2 interactions 4.230E-3 3.833E-2
2.130E-1
6.133E-1
 1 15
17 int:PCDH12 PCDH12 interactions 5.074E-3 3.883E-2
2.158E-1
7.357E-1
 1 18
18 int:ST14 ST14 interactions 5.074E-3 3.883E-2
2.158E-1
7.357E-1
 1 18
19 int:HDHD2 HDHD2 interactions 5.355E-3 3.883E-2
2.158E-1
7.765E-1
 1 19
20 int:CCDC106 CCDC106 interactions 5.355E-3 3.883E-2
2.158E-1
7.765E-1
 1 19
21 int:PITHD1 PITHD1 interactions 5.918E-3 3.910E-2
2.173E-1
8.581E-1
 1 21
22 int:AGR2 AGR2 interactions 7.323E-3 3.910E-2
2.173E-1
1.000E0
 1 26
23 int:YAE1 YAE1 interactions 7.323E-3 3.910E-2
2.173E-1
1.000E0
 1 26
24 int:DPYSL4 DPYSL4 interactions 7.603E-3 3.910E-2
2.173E-1
1.000E0
 1 27
25 int:LRRC1 LRRC1 interactions 7.884E-3 3.910E-2
2.173E-1
1.000E0
 1 28
26 int:PLA2G2A PLA2G2A interactions 8.445E-3 3.910E-2
2.173E-1
1.000E0
 1 30
27 int:GNE GNE interactions 8.445E-3 3.910E-2
2.173E-1
1.000E0
 1 30
28 int:OTUD6B OTUD6B interactions 9.006E-3 3.910E-2
2.173E-1
1.000E0
 1 32
29 int:PLAU PLAU interactions 9.006E-3 3.910E-2
2.173E-1
1.000E0
 1 32
30 int:SWAP70 SWAP70 interactions 9.287E-3 3.910E-2
2.173E-1
1.000E0
 1 33
31 int:ADCYAP1 ADCYAP1 interactions 9.567E-3 3.910E-2
2.173E-1
1.000E0
 1 34
32 int:EDEM1 EDEM1 interactions 9.847E-3 3.910E-2
2.173E-1
1.000E0
 1 35
33 int:DPYSL3 DPYSL3 interactions 1.013E-2 3.910E-2
2.173E-1
1.000E0
 1 36
34 int:ARL15 ARL15 interactions 1.013E-2 3.910E-2
2.173E-1
1.000E0
 1 36
35 int:SERPINB9 SERPINB9 interactions 1.041E-2 3.910E-2
2.173E-1
1.000E0
 1 37
36 int:TNFSF8 TNFSF8 interactions 1.097E-2 3.910E-2
2.173E-1
1.000E0
 1 39
37 int:PLAT PLAT interactions 1.125E-2 3.910E-2
2.173E-1
1.000E0
 1 40
38 int:DUSP4 DUSP4 interactions 1.153E-2 3.910E-2
2.173E-1
1.000E0
 1 41
39 int:PPT1 PPT1 interactions 1.181E-2 3.910E-2
2.173E-1
1.000E0
 1 42
40 int:NVL NVL interactions 1.209E-2 3.910E-2
2.173E-1
1.000E0
 1 43
41 int:PARVA PARVA interactions 1.237E-2 3.910E-2
2.173E-1
1.000E0
 1 44
42 int:BTBD2 BTBD2 interactions 1.237E-2 3.910E-2
2.173E-1
1.000E0
 1 44
43 int:ARMC1 ARMC1 interactions 1.265E-2 3.910E-2
2.173E-1
1.000E0
 1 45
44 int:PAFAH1B3 PAFAH1B3 interactions 1.293E-2 3.910E-2
2.173E-1
1.000E0
 1 46
45 int:MAP3K20 MAP3K20 interactions 1.293E-2 3.910E-2
2.173E-1
1.000E0
 1 46
46 int:SLC39A5 SLC39A5 interactions 1.293E-2 3.910E-2
2.173E-1
1.000E0
 1 46
47 int:CEACAM21 CEACAM21 interactions 1.321E-2 3.910E-2
2.173E-1
1.000E0
 1 47
48 int:EDEM2 EDEM2 interactions 1.321E-2 3.910E-2
2.173E-1
1.000E0
 1 47
49 int:CDK5RAP3 CDK5RAP3 interactions 1.349E-2 3.910E-2
2.173E-1
1.000E0
 1 48
50 int:DERL2 DERL2 interactions 1.349E-2 3.910E-2
2.173E-1
1.000E0
 1 48
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 4q32 4q32 8.653E-4 4.326E-3 9.879E-3 4.326E-3 1 6
2 11q13.3 11q13.3 3.601E-3 6.482E-3 1.480E-2 1.801E-2 1 25
3 7q36 7q36 3.889E-3 6.482E-3 1.480E-2 1.945E-2 1 27
4 11q24.2 11q24.2 9.342E-3 1.168E-2 2.666E-2 4.671E-2 1 65
5 4p16.1 4p16.1 1.277E-2 1.277E-2 2.917E-2
6.387E-2
 1 89

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 65 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 2 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 555 Receptor Tyrosine Kinases|Fibronectin type III domain containing|V-set domain containing|Immunoglobulin like domain containing genenames.org 1.751E-2 2.588E-2
5.392E-2
7.005E-2
 1 160
2 593 Fibronectin type III domain containing|I-set domain containing|Immunoglobulin like domain containing genenames.org 1.762E-2 2.588E-2
5.392E-2
7.048E-2
 1 161
3 594 Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing genenames.org 2.110E-2 2.588E-2
5.392E-2
8.442E-2
 1 193
4 542 Endogenous ligands genenames.org 2.588E-2 2.588E-2
5.392E-2
1.035E-1
 1 237

13: Coexpression [Display Chart] 5 input genes in category / 472 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18049111-Table2 Human Viral Mas07 26genes GeneSigDB 9.436E-6 4.454E-3 3.000E-2 4.454E-3 2 23
2 M5919 Genes up-regulated by activation of hedgehog signaling. MSigDB H: Hallmark Gene Sets (v6.0) 2.347E-5 5.539E-3 3.730E-2 1.108E-2 2 36
3 21205295-TableS2 Mouse Viral Buonomo11 116genes GeneSigDB 2.022E-4 2.912E-2
1.961E-1
9.543E-2
 2 105
4 M1348 Genes up-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 12 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.468E-4 2.912E-2
1.961E-1
1.165E-1
 2 116
5 M2765 Genes down-regulated during late stages of differentiation of embryoid bodies from J1 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v6.0) 6.327E-4 3.136E-2
2.112E-1
2.986E-1
 2 186
6 M2771 Genes down-regulated during late stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v6.0) 6.327E-4 3.136E-2
2.112E-1
2.986E-1
 2 186
7 15501955-Table2 Human Breast Bieche04 3genes relapsed GeneSigDB 6.482E-4 3.136E-2
2.112E-1
3.060E-1
 1 3
8 M4914 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee at day 3 post-vaccination versus those at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 6.950E-4 3.136E-2
2.112E-1
3.280E-1
 2 195
9 M10091 Genes down-regulated in mucinous ovarian carcinoma tumors of low malignant potential (LMP) compared to normal ovarian surface epithelium tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.236E-4 3.136E-2
2.112E-1
3.415E-1
 2 199
10 M7159 Genes up-regulated in CD4 [GeneID=920] T cells treated with HDAC inhibitors: 2h versus 12h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 3.136E-2
2.112E-1
3.450E-1
 2 200
11 M3209 Genes up-regulated in comparison of immature NK cells versus intermediate mature NK cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 3.136E-2
2.112E-1
3.450E-1
 2 200
12 M2521 Loci bound by both isoforms (a and b) of SALL4 [GeneID=57167] in ES cells (embryonic stem). MSigDB C2: CGP Curated Gene Sets (v6.0) 9.399E-4 3.697E-2
2.490E-1
4.436E-1
 2 227
13 15173083-Table3 Human Brain Levy04 12genes GeneSigDB 1.728E-3 4.963E-2
3.343E-1
8.155E-1
 1 8
14 M1924 Genes up-regulated in partially reprogrammed and pluripotent cell populations (induced, iPS; and embryonic stem cells, ES) compared to parental lineage-commited cell lines. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.728E-3 4.963E-2
3.343E-1
8.155E-1
 1 8
15 17533364-TableS3 Human Brain Lastowska07 548genes GeneSigDB 1.971E-3 4.963E-2
3.343E-1
9.305E-1
 2 330
16 18427120-DataS4 Human Breast Crawford08 971genes GeneSigDB 2.340E-3 4.963E-2
3.343E-1
1.000E0
 2 360
17 17963910-Table2 Human Breast Rodningen08 18genes GeneSigDB 3.238E-3 4.963E-2
3.343E-1
1.000E0
 1 15
18 19181379-Table1 Mouse Viral Pekova09 22genes GeneSigDB 3.238E-3 4.963E-2
3.343E-1
1.000E0
 1 15
19 20460173-ImmPortCytokines Human Immune Kong10 456genes ImmPort Cytokines GeneSigDB 3.366E-3 4.963E-2
3.343E-1
1.000E0
 2 433
20 M15351 High-level amplifications detected in oral squamous cell carcinoma (OSCC) lines by array-CGH analysis. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.453E-3 4.963E-2
3.343E-1
1.000E0
 1 16
21 16007088-Table1 Human StemCell Weber05 18genes GeneSigDB 3.669E-3 4.963E-2
3.343E-1
1.000E0
 1 17
22 17325667-Table1a Human Stomach Mahadevan07 20genes OverExpressedGIST-RvsGIST-S GeneSigDB 3.669E-3 4.963E-2
3.343E-1
1.000E0
 1 17
23 16203795-Table1 Human Bladder Blaveri05 29genes GeneSigDB 3.884E-3 4.963E-2
3.343E-1
1.000E0
 1 18
24 M1388 Cluster 5 of genes distinguishing among different B lymphocyte neoplasms. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.884E-3 4.963E-2
3.343E-1
1.000E0
 1 18
25 18199535-SuppTable2 Human StemCell Amundson08 18genes GeneSigDB 3.884E-3 4.963E-2
3.343E-1
1.000E0
 1 18
26 M14473 Genes identified as hypermethylated in SW48 cells (colon cancer). MSigDB C2: CGP Curated Gene Sets (v6.0) 3.884E-3 4.963E-2
3.343E-1
1.000E0
 1 18
27 15520187-Table2b Human Bladder Nicholson04 20genes Loss GeneSigDB 4.100E-3 4.963E-2
3.343E-1
1.000E0
 1 19
28 M1350 Genes up-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 48 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.239E-3 4.963E-2
3.343E-1
1.000E0
 2 487
29 M7657 Gene predicting resistance of the NCI-60 cell lines to gamma radiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.315E-3 4.963E-2
3.343E-1
1.000E0
 1 20
30 15173083-Table2 Human Brain Levy04 32genes GeneSigDB 4.530E-3 4.963E-2
3.343E-1
1.000E0
 1 21
31 M7184 Genes up-regulated in glioblastoma cell lines displaying spherical growth (cluster-1) compared to those displaying semiadherent or adherent growth phenotype (cluster-2). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.530E-3 4.963E-2
3.343E-1
1.000E0
 1 21
32 M7346 Top 25 most highly expressed genes in embryonic carcinoma relative to seminoma tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.746E-3 4.963E-2
3.343E-1
1.000E0
 1 22
33 M18876 Top genes up-regulated in the GIST (gastrointestinal stromal tumor) cell line resistant to imatinib [PubChem=5291] compared to the parental cell line sensitive to the drug. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.961E-3 4.963E-2
3.343E-1
1.000E0
 1 23
34 M672 Genes from common regions of gains observed in more than 15% of 148 primary breast cancer tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.822E-3 4.963E-2
3.343E-1
1.000E0
 1 27
35 M8526 Protein profiles associated with survival in lung adenocarcinoma. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.822E-3 4.963E-2
3.343E-1
1.000E0
 1 27
36 16514666-Table2 Rat Immune Molloy06 46genes GeneSigDB 6.037E-3 4.963E-2
3.343E-1
1.000E0
 1 28
37 16581771-table1 Mouse StemCell Si06 35genes GeneSigDB 6.467E-3 4.963E-2
3.343E-1
1.000E0
 1 30
38 20458058-TableS3a Human HeadandNeck Thurlow10 31genes GeneSigDB 6.467E-3 4.963E-2
3.343E-1
1.000E0
 1 30
39 M15762 Neuroblastoma markers down-regulated in neuroblastoma cell lines expressing ESWR1-FLI1 [GeneID=2130;2313] fusion protein. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.467E-3 4.963E-2
3.343E-1
1.000E0
 1 30
40 M1291 Candidate mammary tumorigenesis genes from the common insertion sites (CIS) of MMTV virus that induced breast tumors in mice. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.682E-3 4.963E-2
3.343E-1
1.000E0
 1 31
41 15013775-Table1 Human Leukemia Fu04 32genes GeneSigDB 6.682E-3 4.963E-2
3.343E-1
1.000E0
 1 31
42 18593912-Table1 Mouse StemCell Shachaf08 35genes GeneSigDB 7.112E-3 4.963E-2
3.343E-1
1.000E0
 1 33
43 12086872-Table11d Human Leukemia Yeoh02 40genes TEL-AML1 GeneSigDB 7.541E-3 4.963E-2
3.343E-1
1.000E0
 1 35
44 M13276 Genes down-regulated by IL2 [GeneID=3558] in cells derived from CD4+ [GeneID=920] cutaneous T-cell lymphoma (CTCL). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.756E-3 4.963E-2
3.343E-1
1.000E0
 1 36
45 17575140-Table1 Human Prostate Verona07 41genes GeneSigDB 7.756E-3 4.963E-2
3.343E-1
1.000E0
 1 36
46 M1187 Genes down-regulated in MCF7 cells (breast cancer, normal TP53 [GeneID=7157]) undergoing mitotic arrest and apoptosis after treatment with 100 nM docetaxel [PubChem=148124]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.186E-3 4.963E-2
3.343E-1
1.000E0
 1 38
47 M2550 Genes distinguishing vincristine [PubChem=5978] resistant and sensitive B-lineage ALL; here - genes up-regulated in the drug resistant samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.186E-3 4.963E-2
3.343E-1
1.000E0
 1 38
48 15671244-Table1 Mouse Breast Eckhardt05 43genes GeneSigDB 8.400E-3 4.963E-2
3.343E-1
1.000E0
 1 39
49 20458058-TableS3b Human HeadandNeck Thurlow10 42genes GeneSigDB 8.615E-3 4.963E-2
3.343E-1
1.000E0
 1 40
50 17060636-Table1 Mouse Lung not cancer Fulkerson06 45genes GeneSigDB 8.615E-3 4.963E-2
3.343E-1
1.000E0
 1 40
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 707 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 4 input genes in category / 15 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 5 input genes in category / 126 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-6867-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.524E-6 3.181E-4 1.723E-3 3.181E-4 3 459
2 hsa-miR-4455:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.162E-5 2.761E-3 1.496E-2 6.504E-3 2 165
3 hsa-miR-362-3p:PITA hsa-miR-362-3p:PITA TOP PITA 8.765E-5 2.761E-3 1.496E-2 1.104E-2 2 215
4 hsa-miR-329:PITA hsa-miR-329:PITA TOP PITA 8.765E-5 2.761E-3 1.496E-2 1.104E-2 2 215
5 hsa-miR-768-3p:PITA hsa-miR-768-3p:PITA TOP PITA 2.438E-4 6.145E-3 3.329E-2 3.072E-2 2 359
6 hsa-miR-574-5p:Functional MTI Functional MTI miRTarbase 3.255E-4 6.228E-3 3.374E-2 4.101E-2 2 415
7 hsa-miR-1471:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.460E-4 6.228E-3 3.374E-2 4.360E-2 1 5
8 hsa-miR-187-3p:TargetScan hsa-miR-187-3p TargetScan 1.245E-3 1.961E-2
1.063E-1
1.569E-1
 1 18
9 hsa-miR-187-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.591E-3 2.227E-2
1.207E-1
2.005E-1
 1 23
10 hsa-miR-151b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.904E-3 2.921E-2
1.583E-1
3.659E-1
 1 42
11 hsa-miR-4781-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.456E-3 2.921E-2
1.583E-1
4.354E-1
 1 50
12 hsa-miR-4484:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.215E-3 2.921E-2
1.583E-1
5.311E-1
 1 61
13 hsa-miR-3614-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-3 2.921E-2
1.583E-1
5.745E-1
 1 66
14 hsa-miR-4313:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.698E-3 2.921E-2
1.583E-1
5.919E-1
 1 68
15 hsa-miR-6882-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.767E-3 2.921E-2
1.583E-1
6.006E-1
 1 69
16 hsa-miR-7108-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.387E-3 2.921E-2
1.583E-1
6.788E-1
 1 78
17 hsa-miR-1251-5p:TargetScan hsa-miR-1251-5p TargetScan 5.456E-3 2.921E-2
1.583E-1
6.875E-1
 1 79
18 hsa-miR-151a-5p:Functional MTI Functional MTI miRTarbase 5.456E-3 2.921E-2
1.583E-1
6.875E-1
 1 79
19 hsa-miR-1234:mirSVR highEffct hsa-miR-1234:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.076E-3 2.921E-2
1.583E-1
7.656E-1
 1 88
20 hsa-miR-1251:PITA hsa-miR-1251:PITA TOP PITA 6.145E-3 2.921E-2
1.583E-1
7.743E-1
 1 89
21 hsa-miR-215:PITA hsa-miR-215:PITA TOP PITA 6.558E-3 2.921E-2
1.583E-1
8.263E-1
 1 95
22 hsa-miR-192:PITA hsa-miR-192:PITA TOP PITA 6.558E-3 2.921E-2
1.583E-1
8.263E-1
 1 95
23 hsa-miR-595:Functional MTI Functional MTI miRTarbase 6.971E-3 2.921E-2
1.583E-1
8.784E-1
 1 101
24 GGTGTGT,MIR-329:MSigDB GGTGTGT,MIR-329:MSigDB MSigDB 7.109E-3 2.921E-2
1.583E-1
8.957E-1
 1 103
25 hsa-miR-6768-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.178E-3 2.921E-2
1.583E-1
9.044E-1
 1 104
26 hsa-miR-889-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.246E-3 2.921E-2
1.583E-1
9.131E-1
 1 105
27 hsa-miR-7109-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.553E-3 2.921E-2
1.583E-1
1.000E0
 1 124
28 hsa-miR-548an:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.553E-3 2.921E-2
1.583E-1
1.000E0
 1 124
29 hsa-miR-1913:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.966E-3 2.921E-2
1.583E-1
1.000E0
 1 130
30 hsa-miR-1292-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.378E-3 2.921E-2
1.583E-1
1.000E0
 1 136
31 hsa-miR-134-5p:TargetScan hsa-miR-134-5p TargetScan 9.790E-3 2.921E-2
1.583E-1
1.000E0
 1 142
32 hsa-miR-147a:Functional MTI Functional MTI miRTarbase 1.027E-2 2.921E-2
1.583E-1
1.000E0
 1 149
33 hsa-miR-197:PITA hsa-miR-197:PITA TOP PITA 1.048E-2 2.921E-2
1.583E-1
1.000E0
 1 152
34 hsa-miR-937:mirSVR lowEffct hsa-miR-937:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.103E-2 2.921E-2
1.583E-1
1.000E0
 1 160
35 hsa-miR-6818-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.116E-2 2.921E-2
1.583E-1
1.000E0
 1 162
36 hsa-miR-192-5p:TargetScan hsa-miR-192-5p TargetScan 1.123E-2 2.921E-2
1.583E-1
1.000E0
 1 163
37 hsa-miR-215-5p:TargetScan hsa-miR-215-5p TargetScan 1.123E-2 2.921E-2
1.583E-1
1.000E0
 1 163
38 hsa-miR-1265:PITA hsa-miR-1265:PITA TOP PITA 1.171E-2 2.921E-2
1.583E-1
1.000E0
 1 170
39 hsa-miR-219-5p:PITA hsa-miR-219-5p:PITA TOP PITA 1.185E-2 2.921E-2
1.583E-1
1.000E0
 1 172
40 hsa-miR-1206:PITA hsa-miR-1206:PITA TOP PITA 1.205E-2 2.921E-2
1.583E-1
1.000E0
 1 175
41 hsa-miR-6083:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.226E-2 2.921E-2
1.583E-1
1.000E0
 1 178
42 hsa-miR-6887-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.247E-2 2.921E-2
1.583E-1
1.000E0
 1 181
43 TGTGTGA,MIR-377:MSigDB TGTGTGA,MIR-377:MSigDB MSigDB 1.267E-2 2.921E-2
1.583E-1
1.000E0
 1 184
44 hsa-miR-297:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.308E-2 2.921E-2
1.583E-1
1.000E0
 1 190
45 hsa-miR-567:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.315E-2 2.921E-2
1.583E-1
1.000E0
 1 191
46 CTTGTAT,MIR-381:MSigDB CTTGTAT,MIR-381:MSigDB MSigDB 1.322E-2 2.921E-2
1.583E-1
1.000E0
 1 192
47 hsa-miR-146a-5p:TargetScan hsa-miR-146a-5p TargetScan 1.336E-2 2.921E-2
1.583E-1
1.000E0
 1 194
48 hsa-miR-146b-5p:TargetScan hsa-miR-146b-5p TargetScan 1.336E-2 2.921E-2
1.583E-1
1.000E0
 1 194
49 hsa-let-7d*:mirSVR highEffct hsa-let-7d*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.342E-2 2.921E-2
1.583E-1
1.000E0
 1 195
50 hsa-miR-96-5p:Functional MTI Functional MTI miRTarbase 1.383E-2 2.921E-2
1.583E-1
1.000E0
 1 201
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 1214 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2751 UP Pyridoxine hydrochloride [58-56-0]; Up 200; 19.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.239E-6 7.574E-3
5.816E-2
 7.574E-3 3 197
2 CID000043490 Db-f Stitch 1.897E-5 1.151E-2
8.840E-2
 2.302E-2 2 32
3 CID000006536 triparanol Stitch 5.461E-5 2.171E-2
1.667E-1
6.630E-2
 2 54
4 CID000001401 PD173074 Stitch 7.930E-5 2.171E-2
1.667E-1
9.627E-2
 2 65
5 CID004620597 Bmps Stitch 8.941E-5 2.171E-2
1.667E-1
1.085E-1
 2 69
6 CID000006956 phthalamide Stitch 1.234E-4 2.242E-2
1.722E-1
1.498E-1
 2 81
7 CID000057697 pemirolast Stitch 1.295E-4 2.242E-2
1.722E-1
1.573E-1
 2 83
8 CID005326798 DB08181 Stitch 1.627E-4 2.242E-2
1.722E-1
1.975E-1
 2 93
9 CID000452221 AC1L9Q5W Stitch 2.114E-4 2.242E-2
1.722E-1
2.567E-1
 2 106
10 CID000131391 HhNp Stitch 2.189E-4 2.242E-2
1.722E-1
2.658E-1
 1 1
11 CID000492400 NVP & EFV Stitch 2.754E-4 2.242E-2
1.722E-1
3.344E-1
 2 121
12 CID000005307 A19413 Stitch 3.228E-4 2.242E-2
1.722E-1
3.918E-1
 2 131
13 CID006327182 tellurium Stitch 3.327E-4 2.242E-2
1.722E-1
4.039E-1
 2 133
14 CID000125581 SHNH Stitch 4.378E-4 2.242E-2
1.722E-1
5.315E-1
 1 2
15 CID000062322 diethoxydimethylsilane Stitch 4.378E-4 2.242E-2
1.722E-1
5.315E-1
 1 2
16 CID003016737 3-sulfinopropionate Stitch 4.378E-4 2.242E-2
1.722E-1
5.315E-1
 1 2
17 CID000020518 11-deoxojervine Stitch 5.814E-4 2.242E-2
1.722E-1
7.059E-1
 2 176
18 DB00686 Pentosan Polysulfate Drug Bank 6.566E-4 2.242E-2
1.722E-1
7.971E-1
 1 3
19 CID006852188 3 SP Stitch 6.566E-4 2.242E-2
1.722E-1
7.971E-1
 1 3
20 3641 UP Finasteride [98319-26-7]; Up 200; 10.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.057E-4 2.242E-2
1.722E-1
8.567E-1
 2 194
21 4960 UP Miconazole [22916-47-8]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.130E-4 2.242E-2
1.722E-1
8.655E-1
 2 195
22 3564 UP Meropenem [96036-03-2]; Up 200; 10.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.203E-4 2.242E-2
1.722E-1
8.744E-1
 2 196
23 6303 UP Amphotericin B [1397-89-3]; Up 200; 4.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.203E-4 2.242E-2
1.722E-1
8.744E-1
 2 196
24 3983 DN Nafcillin sodium salt monohydrate [7177-50-6]; Down 200; 8.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.276E-4 2.242E-2
1.722E-1
8.833E-1
 2 197
25 5808 UP Tomatidine [77-59-8]; Up 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.276E-4 2.242E-2
1.722E-1
8.833E-1
 2 197
26 3930 DN N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.276E-4 2.242E-2
1.722E-1
8.833E-1
 2 197
27 5964 UP ICI182,780; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.276E-4 2.242E-2
1.722E-1
8.833E-1
 2 197
28 6383 DN Orlistat; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.276E-4 2.242E-2
1.722E-1
8.833E-1
 2 197
29 3937 DN Flecainide acetate [54143-56-5]; Down 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.276E-4 2.242E-2
1.722E-1
8.833E-1
 2 197
30 4081 DN Tobramycin [32986-56-4]; Down 200; 8.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.349E-4 2.242E-2
1.722E-1
8.922E-1
 2 198
31 2867 UP Triflusal [322-79-2]; Up 200; 16.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.349E-4 2.242E-2
1.722E-1
8.922E-1
 2 198
32 2279 UP Chlorphensin carbamate [886-74-8]; Up 200; 16.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.349E-4 2.242E-2
1.722E-1
8.922E-1
 2 198
33 2271 UP Hyoscyamine (L) [101-31-5]; Up 200; 13.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.349E-4 2.242E-2
1.722E-1
8.922E-1
 2 198
34 6153 DN Ondansetron Hydrochloride [103639-04-9]; Down 200; 12.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 7.349E-4 2.242E-2
1.722E-1
8.922E-1
 2 198
35 3891 UP Lycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.349E-4 2.242E-2
1.722E-1
8.922E-1
 2 198
36 6123 DN Meprylcaine hydrochloride [956-03-6]; Down 200; 14.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 7.423E-4 2.242E-2
1.722E-1
9.012E-1
 2 199
37 5806 UP Suxibuzone [27470-51-5]; Up 200; 9.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.423E-4 2.242E-2
1.722E-1
9.012E-1
 2 199
38 3898 UP Methimazole [60-56-0]; Up 200; 35uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.423E-4 2.242E-2
1.722E-1
9.012E-1
 2 199
39 4077 DN Diflorasone Diacetate [33564-31-7]; Down 200; 8uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.498E-4 2.242E-2
1.722E-1
9.102E-1
 2 200
40 CID000004101 methenamine silver Stitch 7.572E-4 2.242E-2
1.722E-1
9.193E-1
 2 201
41 CID000000573 ss,ss-carotene Stitch 7.572E-4 2.242E-2
1.722E-1
9.193E-1
 2 201
42 CID000003496 glyphosate Stitch 8.656E-4 2.471E-2
1.898E-1
1.000E0
 2 215
43 CID009793819 Hawleyite Stitch 8.754E-4 2.471E-2
1.898E-1
1.000E0
 1 4
44 CID006540261 EI-N Stitch 1.041E-3 2.711E-2
2.082E-1
1.000E0
 2 236
45 CID000150879 Cys-tyr Stitch 1.094E-3 2.711E-2
2.082E-1
1.000E0
 1 5
46 CID000095116 3,3'-dithiodipropionic acid Stitch 1.094E-3 2.711E-2
2.082E-1
1.000E0
 1 5
47 CID000140487 trichlorosilane Stitch 1.094E-3 2.711E-2
2.082E-1
1.000E0
 1 5
48 ctd:D014047 Tolnaftate CTD 1.094E-3 2.711E-2
2.082E-1
1.000E0
 1 5
49 ctd:C018986 ipriflavone CTD 1.094E-3 2.711E-2
2.082E-1
1.000E0
 1 5
50 CID005282155 kaempferol 3-O-sophoroside Stitch 1.313E-3 3.188E-2
2.448E-1
1.000E0
 1 6
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 321 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0751617 Semilobar Holoprosencephaly DisGeNET Curated 6.921E-6 1.111E-3 7.054E-3 2.222E-3 2 14
2 C0431363 Alobar Holoprosencephaly DisGeNET Curated 6.921E-6 1.111E-3 7.054E-3 2.222E-3 2 14
3 C0431362 Lobar Holoprosencephaly DisGeNET Curated 1.596E-5 1.542E-3 9.795E-3 5.122E-3 2 21
4 C0424711 Orbital separation diminished DisGeNET Curated 1.922E-5 1.542E-3 9.795E-3 6.170E-3 2 23
5 C0079541 Holoprosencephaly DisGeNET Curated 9.653E-5 3.962E-3 2.516E-2 3.098E-2 2 51
6 C0037221 Situs Inversus DisGeNET Curated 1.572E-4 3.962E-3 2.516E-2
5.046E-2
 2 65
7 C0879615 Stromal Neoplasm DisGeNET BeFree 3.085E-4 3.962E-3 2.516E-2
9.902E-2
 2 91
8 C3280215 HOLOPROSENCEPHALY 11 DisGeNET Curated 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
9 C4023728 1-5 finger syndactyly DisGeNET Curated 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
10 C0687082 Proboscis DisGeNET Curated 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
11 OMIN:611638 MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 5; MCOPCB5 OMIM 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
12 OMIN:142945 HOLOPROSENCEPHALY 3; HPE3 OMIM 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
13 C0013568 Ecthyma DisGeNET BeFree 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
14 cv:C1968843 Microphthalmia, isolated, with coloboma 5 Clinical Variations 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
15 C4274307 Hypoplastic tibia and postaxial polydactyly syndrome DisGeNET BeFree 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
16 C1840529 HOLOPROSENCEPHALY 3 DisGeNET Curated 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
17 cv:C1840529 Holoprosencephaly 3 Clinical Variations 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
18 C4082761 Abnormality of limb bone morphology DisGeNET BeFree 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
19 C3276742 Fibular duplication DisGeNET Curated 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
20 C0795803 Chromosome 2, trisomy 2p DisGeNET BeFree 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
21 C1840238 Midnasal stenosis DisGeNET Curated 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
22 cv:C3280215 Holoprosencephaly 11 Clinical Variations 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
23 OMIN:147250 SOLITARY MEDIAN MAXILLARY CENTRAL INCISOR; SMMCI OMIM 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
24 cv:C1840235 Single upper central incisor Clinical Variations 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
25 C1968843 MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 5 (disorder) DisGeNET Curated 3.085E-4 3.962E-3 2.516E-2
9.904E-2
 1 1
26 C1837218 Cleft palate, isolated DisGeNET BeFree 3.433E-4 4.081E-3 2.592E-2
1.102E-1
 2 96
27 C0008924 Cleft Lip DisGeNET Curated 3.433E-4 4.081E-3 2.592E-2
1.102E-1
 2 96
28 C0266981 Torus palatinus DisGeNET Curated 6.170E-4 5.212E-3 3.310E-2
1.981E-1
 1 2
29 C4024806 Irido-fundal coloboma DisGeNET Curated 6.170E-4 5.212E-3 3.310E-2
1.981E-1
 1 2
30 C0334574 Calcifying Epithelial Odontogenic Tumor DisGeNET BeFree 6.170E-4 5.212E-3 3.310E-2
1.981E-1
 1 2
31 C1861355 Syndactyly, Type IV DisGeNET Curated 6.170E-4 5.212E-3 3.310E-2
1.981E-1
 1 2
32 C1868114 POLYDACTYLY, PREAXIAL II (disorder) DisGeNET Curated 6.170E-4 5.212E-3 3.310E-2
1.981E-1
 1 2
33 C0238093 Stenosis of duodenum DisGeNET Curated 6.170E-4 5.212E-3 3.310E-2
1.981E-1
 1 2
34 C1861098 Tibia, Hypoplasia of, with Polydactyly DisGeNET Curated 6.170E-4 5.212E-3 3.310E-2
1.981E-1
 1 2
35 C0265553 Polysyndactyly DisGeNET BeFree 6.170E-4 5.212E-3 3.310E-2
1.981E-1
 1 2
36 C1840236 Prominent midpalatal ridge (torus palatinus) DisGeNET Curated 6.170E-4 5.212E-3 3.310E-2
1.981E-1
 1 2
37 C1861360 6 metacarpals DisGeNET Curated 6.170E-4 5.212E-3 3.310E-2
1.981E-1
 1 2
38 C0447996 Maxillary torus DisGeNET Curated 6.170E-4 5.212E-3 3.310E-2
1.981E-1
 1 2
39 C0266153 Ectopic gastric tissue DisGeNET BeFree 9.254E-4 7.245E-3 4.601E-2
2.971E-1
 1 3
40 cv:C0266484 Schizencephaly Clinical Variations 9.254E-4 7.245E-3 4.601E-2
2.971E-1
 1 3
41 C1335712 Medulloblastoma recurrent DisGeNET BeFree 9.254E-4 7.245E-3 4.601E-2
2.971E-1
 1 3
42 C0240547 Nose deformity DisGeNET Curated 1.234E-3 7.616E-3 4.836E-2
3.960E-1
 1 4
43 C0266484 Schizencephaly DisGeNET Curated 1.234E-3 7.616E-3 4.836E-2
3.960E-1
 1 4
44 C0278876 Medulloblastoma, Adult DisGeNET BeFree 1.234E-3 7.616E-3 4.836E-2
3.960E-1
 1 4
45 C2235909 Malformation of the nose DisGeNET Curated 1.234E-3 7.616E-3 4.836E-2
3.960E-1
 1 4
46 OMIN:120200 COLOBOMA, OCULAR OMIM 1.234E-3 7.616E-3 4.836E-2
3.960E-1
 1 4
47 C0265633 Congenital absence of tibia DisGeNET Curated 1.234E-3 7.616E-3 4.836E-2
3.960E-1
 1 4
48 C4021100 Increased fibular diameter DisGeNET Curated 1.234E-3 7.616E-3 4.836E-2
3.960E-1
 1 4
49 C1531773 Currarino triad DisGeNET Curated 1.234E-3 7.616E-3 4.836E-2
3.960E-1
 1 4
50 C0685869 Monophthalmos DisGeNET BeFree 1.234E-3 7.616E-3 4.836E-2
3.960E-1
 1 4
Show 45 more annotations