|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
21805237
|
The proprotein convertases, 20 years later.
|
Pubmed
|
1.323E-29
|
4.825E-27
|
3.901E-26
|
2.412E-26
|
8
|
9
|
2
|
21805236
|
The prohormone theory and the proprotein convertases: it is all about serendipity.
|
Pubmed
|
1.323E-29
|
4.825E-27
|
3.901E-26
|
2.412E-26
|
8
|
9
|
3
|
23775089
|
The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.
|
Pubmed
|
1.323E-29
|
4.825E-27
|
3.901E-26
|
2.412E-26
|
8
|
9
|
4
|
18343183
|
The activation and physiological functions of the proprotein convertases.
|
Pubmed
|
1.323E-29
|
4.825E-27
|
3.901E-26
|
2.412E-26
|
8
|
9
|
5
|
22679642
|
The biology and therapeutic targeting of the proprotein convertases.
|
Pubmed
|
1.323E-29
|
4.825E-27
|
3.901E-26
|
2.412E-26
|
8
|
9
|
6
|
16163737
|
Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.
|
Pubmed
|
6.616E-29
|
2.010E-26
|
1.625E-25
|
1.206E-25
|
8
|
10
|
7
|
10409610
|
Proteolytic processing in the secretory pathway.
|
Pubmed
|
1.404E-26
|
3.199E-24
|
2.587E-23
|
2.559E-23
|
7
|
7
|
8
|
7819324
|
The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.
|
Pubmed
|
1.404E-26
|
3.199E-24
|
2.587E-23
|
2.559E-23
|
7
|
7
|
9
|
9885250
|
Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.
|
Pubmed
|
1.123E-25
|
2.275E-23
|
1.839E-22
|
2.047E-22
|
7
|
8
|
10
|
8940009
|
Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.
|
Pubmed
|
1.072E-22
|
1.954E-20
|
1.580E-19
|
1.954E-19
|
6
|
6
|
11
|
10037747
|
Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.
|
Pubmed
|
7.504E-22
|
1.244E-19
|
1.006E-18
|
1.368E-18
|
6
|
7
|
12
|
8698813
|
SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.
|
Pubmed
|
9.003E-21
|
1.368E-18
|
1.106E-17
|
1.641E-17
|
6
|
9
|
13
|
20876279
|
Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.
|
Pubmed
|
5.361E-19
|
7.517E-17
|
6.078E-16
|
9.772E-16
|
6
|
15
|
14
|
9242664
|
Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.
|
Pubmed
|
6.824E-19
|
8.293E-17
|
6.706E-16
|
1.244E-15
|
5
|
5
|
15
|
1429684
|
The new enzymology of precursor processing endoproteases.
|
Pubmed
|
6.824E-19
|
8.293E-17
|
6.706E-16
|
1.244E-15
|
5
|
5
|
16
|
9291583
|
Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation.
|
Pubmed
|
4.094E-18
|
4.664E-16
|
3.771E-15
|
7.463E-15
|
5
|
6
|
17
|
9521771
|
Retroviral envelope glycoprotein processing: structural investigation of the cleavage site.
|
Pubmed
|
3.723E-15
|
3.393E-13
|
2.744E-12
|
6.786E-12
|
4
|
4
|
18
|
10900462
|
The proprotein convertases furin and PACE4 play a significant role in tumor progression.
|
Pubmed
|
3.723E-15
|
3.393E-13
|
2.744E-12
|
6.786E-12
|
4
|
4
|
19
|
10701998
|
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.
|
Pubmed
|
3.723E-15
|
3.393E-13
|
2.744E-12
|
6.786E-12
|
4
|
4
|
20
|
18664504
|
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
|
Pubmed
|
3.723E-15
|
3.393E-13
|
2.744E-12
|
6.786E-12
|
4
|
4
|
21
|
11380615
|
Proprotein convertase expression and localization in epidermis: evidence for multiple roles and substrates.
|
Pubmed
|
1.861E-14
|
1.616E-12
|
1.306E-11
|
3.393E-11
|
4
|
5
|
22
|
7782070
|
Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.
|
Pubmed
|
2.604E-13
|
2.158E-11
|
1.745E-10
|
4.748E-10
|
4
|
8
|
23
|
11063880
|
Maturation of HIV envelope glycoprotein precursors by cellular endoproteases.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
24
|
17645548
|
PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
25
|
8995623
|
The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
26
|
1765368
|
Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region).
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
27
|
18096669
|
The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
28
|
22396549
|
Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
29
|
8262946
|
Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
30
|
18706454
|
Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
31
|
10050053
|
Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
32
|
12358783
|
Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
33
|
19339735
|
Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
34
|
18554181
|
Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
35
|
8670066
|
Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
36
|
21147780
|
In vivo evidence that furin from hepatocytes inactivates PCSK9.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
37
|
16912035
|
The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
38
|
11723118
|
Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains.
|
Pubmed
|
1.777E-11
|
8.526E-10
|
6.894E-9
|
3.240E-8
|
3
|
3
|
39
|
12787574
|
Neurotrophin secretion: current facts and future prospects.
|
Pubmed
|
7.107E-11
|
2.879E-9
|
2.328E-8
|
1.296E-7
|
3
|
4
|
40
|
8615794
|
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.
|
Pubmed
|
7.107E-11
|
2.879E-9
|
2.328E-8
|
1.296E-7
|
3
|
4
|
41
|
24101515
|
Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.
|
Pubmed
|
7.107E-11
|
2.879E-9
|
2.328E-8
|
1.296E-7
|
3
|
4
|
42
|
16829522
|
CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces.
|
Pubmed
|
7.107E-11
|
2.879E-9
|
2.328E-8
|
1.296E-7
|
3
|
4
|
43
|
18245819
|
Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.
|
Pubmed
|
7.107E-11
|
2.879E-9
|
2.328E-8
|
1.296E-7
|
3
|
4
|
44
|
23686857
|
Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
|
Pubmed
|
7.107E-11
|
2.879E-9
|
2.328E-8
|
1.296E-7
|
3
|
4
|
45
|
17050541
|
On the processing of proghrelin to ghrelin.
|
Pubmed
|
7.107E-11
|
2.879E-9
|
2.328E-8
|
1.296E-7
|
3
|
4
|
46
|
23918928
|
Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.
|
Pubmed
|
9.944E-10
|
3.941E-8
|
3.186E-7
|
1.813E-6
|
3
|
8
|
47
|
26416966
|
PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.
|
Pubmed
|
1.491E-9
|
5.785E-8
|
4.677E-7
|
2.719E-6
|
3
|
9
|
48
|
15606899
|
Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.
|
Pubmed
|
3.904E-9
|
1.453E-7
|
1.174E-6
|
7.117E-6
|
3
|
12
|
49
|
1354647
|
Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.
|
Pubmed
|
3.904E-9
|
1.453E-7
|
1.174E-6
|
7.117E-6
|
3
|
12
|
50
|
21518694
|
PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke.
|
Pubmed
|
9.932E-9
|
3.621E-7
|
2.928E-6
|
1.811E-5
|
3
|
16
|