Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc260_9, positive side

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1: GO: Molecular Function [Display Chart] 9 input genes in category / 71 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042288 MHC class I protein binding 1.027E-7 3.833E-6 1.858E-5 7.293E-6 3 21
2 GO:0051082 unfolded protein binding 1.080E-7 3.833E-6 1.858E-5 7.666E-6 4 103
3 GO:0042287 MHC protein binding 3.463E-7 8.196E-6 3.973E-5 2.459E-5 3 31
4 GO:0044183 protein binding involved in protein folding 2.164E-5 3.841E-4 1.862E-3 1.536E-3 2 15
5 GO:0042605 peptide antigen binding 1.018E-4 1.445E-3 7.006E-3 7.227E-3 2 32
6 GO:0043531 ADP binding 1.679E-4 1.987E-3 9.630E-3 1.192E-2 2 41
7 GO:0031625 ubiquitin protein ligase binding 2.437E-4 2.028E-3 9.830E-3 1.730E-2 3 273
8 GO:0044389 ubiquitin-like protein ligase binding 2.544E-4 2.028E-3 9.830E-3 1.806E-2 3 277
9 GO:0042277 peptide binding 2.571E-4 2.028E-3 9.830E-3 1.825E-2 3 278
10 GO:0033218 amide binding 3.508E-4 2.490E-3 1.207E-2 2.490E-2 3 309
11 GO:0051087 chaperone binding 6.731E-4 4.344E-3 2.106E-2 4.779E-2 2 82
12 GO:0046980 tapasin binding 9.644E-4 5.267E-3 2.553E-2
6.847E-2
 1 2
13 GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity 9.644E-4 5.267E-3 2.553E-2
6.847E-2
 1 2
14 GO:0003823 antigen binding 1.433E-3 7.204E-3 3.492E-2
1.018E-1
 2 120
15 GO:0023029 MHC class Ib protein binding 1.928E-3 7.204E-3 3.492E-2
1.369E-1
 1 4
16 GO:0015440 peptide-transporting ATPase activity 1.928E-3 7.204E-3 3.492E-2
1.369E-1
 1 4
17 GO:0046978 TAP1 binding 1.928E-3 7.204E-3 3.492E-2
1.369E-1
 1 4
18 GO:0071987 WD40-repeat domain binding 1.928E-3 7.204E-3 3.492E-2
1.369E-1
 1 4
19 GO:0046979 TAP2 binding 1.928E-3 7.204E-3 3.492E-2
1.369E-1
 1 4
20 GO:0046977 TAP binding 3.372E-3 1.140E-2
5.525E-2
2.394E-1
 1 7
21 GO:0016443 bidentate ribonuclease III activity 3.372E-3 1.140E-2
5.525E-2
2.394E-1
 1 7
22 GO:0001849 complement component C1q binding 3.853E-3 1.243E-2
6.026E-2
2.735E-1
 1 8
23 GO:0046703 natural killer cell lectin-like receptor binding 4.814E-3 1.314E-2
6.371E-2
3.418E-1
 1 10
24 GO:0032296 double-stranded RNA-specific ribonuclease activity 4.814E-3 1.314E-2
6.371E-2
3.418E-1
 1 10
25 GO:1904680 peptide transmembrane transporter activity 4.814E-3 1.314E-2
6.371E-2
3.418E-1
 1 10
26 GO:0004525 ribonuclease III activity 4.814E-3 1.314E-2
6.371E-2
3.418E-1
 1 10
27 GO:0030881 beta-2-microglobulin binding 5.294E-3 1.392E-2
6.747E-2
3.759E-1
 1 11
28 GO:1990381 ubiquitin-specific protease binding 5.774E-3 1.464E-2
7.096E-2
4.099E-1
 1 12
29 GO:0051787 misfolded protein binding 6.254E-3 1.531E-2
7.421E-2
4.440E-1
 1 13
30 GO:0001846 opsonin binding 6.733E-3 1.594E-2
7.724E-2
4.781E-1
 1 14
31 GO:0034185 apolipoprotein binding 7.692E-3 1.762E-2
8.539E-2
5.461E-1
 1 16
32 GO:0030246 carbohydrate binding 8.008E-3 1.777E-2
8.612E-2
5.686E-1
 2 289
33 GO:0042887 amide transmembrane transporter activity 9.607E-3 2.067E-2
1.002E-1
6.821E-1
 1 20
34 GO:0001848 complement binding 1.008E-2 2.106E-2
1.021E-1
7.160E-1
 1 21
35 GO:0035255 ionotropic glutamate receptor binding 1.247E-2 2.530E-2
1.226E-1
8.855E-1
 1 26
36 GO:0030544 Hsp70 protein binding 1.628E-2 3.211E-2
1.556E-1
1.000E0
 1 34
37 GO:0051879 Hsp90 protein binding 1.723E-2 3.307E-2
1.603E-1
1.000E0
 1 36
38 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters 1.771E-2 3.309E-2
1.604E-1
1.000E0
 1 37
39 GO:0016887 ATPase activity 1.836E-2 3.342E-2
1.620E-1
1.000E0
 2 446
40 GO:0050681 androgen receptor binding 1.961E-2 3.480E-2
1.687E-1
1.000E0
 1 41
41 GO:0035254 glutamate receptor binding 2.197E-2 3.794E-2
1.839E-1
1.000E0
 1 46
42 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.245E-2 3.794E-2
1.839E-1
1.000E0
 1 47
43 GO:0043022 ribosome binding 2.575E-2 4.252E-2
2.061E-1
1.000E0
 1 54
44 GO:0004521 endoribonuclease activity 2.716E-2 4.383E-2
2.124E-1
1.000E0
 1 57
Show 39 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 508 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0034975 protein folding in endoplasmic reticulum 1.285E-8 6.529E-6 4.446E-5 6.529E-6 3 11
2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 7.522E-8 1.911E-5 1.301E-4 3.821E-5 4 94
3 GO:0030968 endoplasmic reticulum unfolded protein response 2.780E-7 3.870E-5 2.635E-4 1.412E-4 4 130
4 GO:0034620 cellular response to unfolded protein 3.047E-7 3.870E-5 2.635E-4 1.548E-4 4 133
5 GO:0035967 cellular response to topologically incorrect protein 3.852E-7 3.914E-5 2.665E-4 1.957E-4 4 141
6 GO:0006986 response to unfolded protein 8.944E-7 7.255E-5 4.940E-4 4.543E-4 4 174
7 GO:0035966 response to topologically incorrect protein 1.118E-6 7.255E-5 4.940E-4 5.680E-4 4 184
8 GO:0048002 antigen processing and presentation of peptide antigen 1.143E-6 7.255E-5 4.940E-4 5.804E-4 4 185
9 GO:0051708 intracellular protein transport in other organism involved in symbiotic interaction 2.075E-6 9.581E-5 6.523E-4 1.054E-3 2 5
10 GO:0019060 intracellular transport of viral protein in host cell 2.075E-6 9.581E-5 6.523E-4 1.054E-3 2 5
11 GO:0030581 symbiont intracellular protein transport in host 2.075E-6 9.581E-5 6.523E-4 1.054E-3 2 5
12 GO:0019882 antigen processing and presentation 2.816E-6 1.178E-4 8.019E-4 1.430E-3 4 232
13 GO:0006457 protein folding 3.014E-6 1.178E-4 8.019E-4 1.531E-3 4 236
14 GO:0042270 protection from natural killer cell mediated cytotoxicity 4.354E-6 1.383E-4 9.413E-4 2.212E-3 2 7
15 GO:0002488 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway 4.354E-6 1.383E-4 9.413E-4 2.212E-3 2 7
16 GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent 4.354E-6 1.383E-4 9.413E-4 2.212E-3 2 7
17 GO:0034976 response to endoplasmic reticulum stress 4.775E-6 1.427E-4 9.715E-4 2.426E-3 4 265
18 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib 5.804E-6 1.638E-4 1.115E-3 2.949E-3 2 8
19 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib 7.461E-6 1.995E-4 1.358E-3 3.790E-3 2 9
20 GO:0036500 ATF6-mediated unfolded protein response 9.324E-6 2.368E-4 1.612E-3 4.737E-3 2 10
21 GO:0046719 regulation by virus of viral protein levels in host cell 1.139E-5 2.756E-4 1.876E-3 5.788E-3 2 11
22 GO:0032075 positive regulation of nuclease activity 2.173E-5 5.017E-4 3.416E-3 1.104E-2 2 15
23 GO:0002475 antigen processing and presentation via MHC class Ib 2.483E-5 5.255E-4 3.578E-3 1.261E-2 2 16
24 GO:0002483 antigen processing and presentation of endogenous peptide antigen 2.483E-5 5.255E-4 3.578E-3 1.261E-2 2 16
25 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 2.813E-5 5.716E-4 3.892E-3 1.429E-2 2 17
26 GO:0002716 negative regulation of natural killer cell mediated immunity 3.164E-5 6.182E-4 4.209E-3 1.607E-2 2 18
27 GO:0019883 antigen processing and presentation of endogenous antigen 3.535E-5 6.651E-4 4.529E-3 1.796E-2 2 19
28 GO:0001911 negative regulation of leukocyte mediated cytotoxicity 4.339E-5 7.873E-4 5.360E-3 2.204E-2 2 21
29 GO:0032069 regulation of nuclease activity 5.225E-5 9.153E-4 6.232E-3 2.654E-2 2 23
30 GO:0002478 antigen processing and presentation of exogenous peptide antigen 5.617E-5 9.338E-4 6.358E-3 2.853E-2 3 166
31 GO:0031342 negative regulation of cell killing 5.699E-5 9.338E-4 6.358E-3 2.895E-2 2 24
32 GO:0019884 antigen processing and presentation of exogenous antigen 6.352E-5 1.008E-3 6.865E-3 3.227E-2 3 173
33 GO:1900101 regulation of endoplasmic reticulum unfolded protein response 7.797E-5 1.200E-3 8.172E-3 3.961E-2 2 28
34 GO:0031647 regulation of protein stability 1.615E-4 2.414E-3 1.643E-2
8.206E-2
 3 237
35 GO:0042269 regulation of natural killer cell mediated cytotoxicity 1.770E-4 2.531E-3 1.724E-2
8.990E-2
 2 42
36 GO:0006984 ER-nucleus signaling pathway 1.856E-4 2.531E-3 1.724E-2
9.426E-2
 2 43
37 GO:0002715 regulation of natural killer cell mediated immunity 1.856E-4 2.531E-3 1.724E-2
9.426E-2
 2 43
38 GO:0002707 negative regulation of lymphocyte mediated immunity 1.943E-4 2.531E-3 1.724E-2
9.873E-2
 2 44
39 GO:1901998 toxin transport 1.943E-4 2.531E-3 1.724E-2
9.873E-2
 2 44
40 GO:0045824 negative regulation of innate immune response 2.125E-4 2.699E-3 1.838E-2
1.080E-1
 2 46
41 GO:0061077 chaperone-mediated protein folding 2.719E-4 3.368E-3 2.294E-2
1.381E-1
 2 52
42 GO:0002704 negative regulation of leukocyte mediated immunity 3.042E-4 3.680E-3 2.505E-2
1.546E-1
 2 55
43 GO:0042267 natural killer cell mediated cytotoxicity 4.382E-4 4.519E-3 3.077E-2
2.226E-1
 2 66
44 GO:1902583 multi-organism intracellular transport 4.516E-4 4.519E-3 3.077E-2
2.294E-1
 2 67
45 GO:0036498 IRE1-mediated unfolded protein response 4.516E-4 4.519E-3 3.077E-2
2.294E-1
 2 67
46 GO:0001910 regulation of leukocyte mediated cytotoxicity 4.516E-4 4.519E-3 3.077E-2
2.294E-1
 2 67
47 GO:0075733 intracellular transport of virus 4.516E-4 4.519E-3 3.077E-2
2.294E-1
 2 67
48 GO:0002228 natural killer cell mediated immunity 4.789E-4 4.519E-3 3.077E-2
2.433E-1
 2 69
49 GO:0002397 MHC class I protein complex assembly 4.833E-4 4.519E-3 3.077E-2
2.455E-1
 1 1
50 GO:0060904 regulation of protein folding in endoplasmic reticulum 4.833E-4 4.519E-3 3.077E-2
2.455E-1
 1 1
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 85 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030176 integral component of endoplasmic reticulum membrane 3.020E-14 1.658E-12 8.332E-12 2.567E-12 7 137
2 GO:0031227 intrinsic component of endoplasmic reticulum membrane 3.901E-14 1.658E-12 8.332E-12 3.316E-12 7 142
3 GO:0031301 integral component of organelle membrane 5.185E-12 1.469E-10 7.383E-10 4.407E-10 7 283
4 GO:0031300 intrinsic component of organelle membrane 7.115E-12 1.512E-10 7.598E-10 6.048E-10 7 296
5 GO:0098553 lumenal side of endoplasmic reticulum membrane 2.643E-7 3.745E-6 1.882E-5 2.247E-5 3 29
6 GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane 2.643E-7 3.745E-6 1.882E-5 2.247E-5 3 29
7 GO:0098576 lumenal side of membrane 3.943E-7 4.788E-6 2.406E-5 3.352E-5 3 33
8 GO:0005790 smooth endoplasmic reticulum 6.596E-7 7.008E-6 3.522E-5 5.606E-5 3 39
9 GO:0042824 MHC class I peptide loading complex 1.980E-6 1.870E-5 9.400E-5 1.683E-4 2 5
10 GO:0018995 host 3.375E-5 2.608E-4 1.311E-3 2.869E-3 2 19
11 GO:0043657 host cell 3.375E-5 2.608E-4 1.311E-3 2.869E-3 2 19
12 GO:0044217 other organism part 5.440E-5 3.303E-4 1.660E-3 4.624E-3 2 24
13 GO:0044216 other organism cell 5.440E-5 3.303E-4 1.660E-3 4.624E-3 2 24
14 GO:0044215 other organism 5.440E-5 3.303E-4 1.660E-3 4.624E-3 2 24
15 GO:0005788 endoplasmic reticulum lumen 1.010E-4 5.726E-4 2.878E-3 8.589E-3 3 207
16 GO:1990332 Ire1 complex 4.722E-4 2.508E-3 1.261E-2 4.013E-2 1 1
17 GO:1990630 IRE1-RACK1-PP2A complex 9.441E-4 4.224E-3 2.123E-2
8.025E-2
 1 2
18 GO:0036502 Derlin-1-VIMP complex 9.441E-4 4.224E-3 2.123E-2
8.025E-2
 1 2
19 GO:0032398 MHC class Ib protein complex 9.441E-4 4.224E-3 2.123E-2
8.025E-2
 1 2
20 GO:0042470 melanosome 1.055E-3 4.271E-3 2.146E-2
8.968E-2
 2 105
21 GO:0048770 pigment granule 1.055E-3 4.271E-3 2.146E-2
8.968E-2
 2 105
22 GO:0001669 acrosomal vesicle 1.220E-3 4.715E-3 2.370E-2
1.037E-1
 2 113
23 GO:1990597 AIP1-IRE1 complex 1.416E-3 5.233E-3 2.630E-2
1.204E-1
 1 3
24 GO:0042825 TAP complex 1.887E-3 6.417E-3 3.225E-2
1.604E-1
 1 4
25 GO:1990604 IRE1-TRAF2-ASK1 complex 1.887E-3 6.417E-3 3.225E-2
1.604E-1
 1 4
26 GO:0097223 sperm part 3.191E-3 1.039E-2
5.223E-2
2.712E-1
 2 184
27 GO:0044233 Mitochondria-associated ER Membrane 3.301E-3 1.039E-2
5.223E-2
2.806E-1
 1 7
28 GO:0033018 sarcoplasmic reticulum lumen 3.772E-3 1.123E-2
5.643E-2
3.206E-1
 1 8
29 GO:0043209 myelin sheath 3.831E-3 1.123E-2
5.643E-2
3.256E-1
 2 202
30 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex 4.242E-3 1.163E-2
5.846E-2
3.606E-1
 1 9
31 GO:0005832 chaperonin-containing T-complex 4.242E-3 1.163E-2
5.846E-2
3.606E-1
 1 9
32 GO:0036513 Derlin-1 retrotranslocation complex 5.183E-3 1.259E-2
6.326E-2
4.406E-1
 1 11
33 GO:0044232 organelle membrane contact site 5.183E-3 1.259E-2
6.326E-2
4.406E-1
 1 11
34 GO:0042612 MHC class I protein complex 5.183E-3 1.259E-2
6.326E-2
4.406E-1
 1 11
35 GO:0002199 zona pellucida receptor complex 5.183E-3 1.259E-2
6.326E-2
4.406E-1
 1 11
36 GO:0034663 endoplasmic reticulum chaperone complex 5.653E-3 1.335E-2
6.708E-2
4.805E-1
 1 12
37 GO:0030139 endocytic vesicle 6.500E-3 1.493E-2
7.504E-2
5.525E-1
 2 265
38 GO:0031965 nuclear membrane 7.739E-3 1.731E-2
8.700E-2
6.578E-1
 2 290
39 GO:0071682 endocytic vesicle lumen 8.000E-3 1.744E-2
8.763E-2
6.800E-1
 1 17
40 GO:0005769 early endosome 9.022E-3 1.917E-2
9.635E-2
7.668E-1
 2 314
41 GO:1902555 endoribonuclease complex 9.874E-3 1.998E-2
1.004E-1
8.393E-1
 1 21
42 GO:0032839 dendrite cytoplasm 9.874E-3 1.998E-2
1.004E-1
8.393E-1
 1 21
43 GO:0042611 MHC protein complex 1.268E-2 2.506E-2
1.260E-1
1.000E0
 1 27
44 GO:0005925 focal adhesion 1.387E-2 2.631E-2
1.322E-1
1.000E0
 2 393
45 GO:0005924 cell-substrate adherens junction 1.421E-2 2.631E-2
1.322E-1
1.000E0
 2 398
46 GO:0030141 secretory granule 1.434E-2 2.631E-2
1.322E-1
1.000E0
 2 400
47 GO:0030055 cell-substrate junction 1.455E-2 2.631E-2
1.322E-1
1.000E0
 2 403
48 GO:0008180 COP9 signalosome 1.594E-2 2.823E-2
1.419E-1
1.000E0
 1 34
49 GO:0005635 nuclear envelope 1.824E-2 3.164E-2
1.590E-1
1.000E0
 2 454
50 GO:0005912 adherens junction 2.058E-2 3.499E-2
1.758E-1
1.000E0
 2 484
Show 45 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 157 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 8 input genes in category / 315 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 9 input genes in category / 85 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00805 CALRETICULIN REPEAT PROSITE 6.153E-7 1.494E-5 7.508E-5 5.230E-5 2 3
2 2.10.250.10 - Gene3D 6.153E-7 1.494E-5 7.508E-5 5.230E-5 2 3
3 IPR001580 Calret/calnex InterPro 1.230E-6 1.494E-5 7.508E-5 1.046E-4 2 4
4 PS00803 CALRETICULIN 1 PROSITE 1.230E-6 1.494E-5 7.508E-5 1.046E-4 2 4
5 IPR018124 Calret/calnex CS InterPro 1.230E-6 1.494E-5 7.508E-5 1.046E-4 2 4
6 PS00804 CALRETICULIN 2 PROSITE 1.230E-6 1.494E-5 7.508E-5 1.046E-4 2 4
7 PF00262 Calreticulin Pfam 1.230E-6 1.494E-5 7.508E-5 1.046E-4 2 4
8 IPR009033 Calreticulin/calnexin P dom InterPro 2.050E-6 2.178E-5 1.095E-4 1.742E-4 2 5
9 PS00014 ER TARGET PROSITE 2.193E-4 2.071E-3 1.041E-2 1.864E-2 2 47
10 IPR013969 Oligosacch biosynth Alg14 InterPro 4.804E-4 3.712E-3 1.866E-2 4.083E-2 1 1
11 PF08660 Alg14 Pfam 4.804E-4 3.712E-3 1.866E-2 4.083E-2 1 1
12 2.60.120.200 - Gene3D 8.950E-4 4.803E-3 2.414E-2
7.607E-2
 2 95
13 IPR013306 Tap1/ABCB2 InterPro 9.606E-4 4.803E-3 2.414E-2
8.165E-2
 1 2
14 IPR013305 ABC Tap-like InterPro 9.606E-4 4.803E-3 2.414E-2
8.165E-2
 1 2
15 IPR009169 Calreticulin InterPro 9.606E-4 4.803E-3 2.414E-2
8.165E-2
 1 2
16 IPR005293 Tap2/ABCB3 InterPro 9.606E-4 4.803E-3 2.414E-2
8.165E-2
 1 2
17 IPR012722 Chap CCT zeta InterPro 9.606E-4 4.803E-3 2.414E-2
8.165E-2
 1 2
18 PS51392 KEN PROSITE 1.441E-3 5.566E-3 2.797E-2
1.224E-1
 1 3
19 PF06479 Ribonuc 2-5A Pfam 1.441E-3 5.566E-3 2.797E-2
1.224E-1
 1 3
20 PF01011 PQQ Pfam 1.441E-3 5.566E-3 2.797E-2
1.224E-1
 1 3
21 IPR010513 KEN dom InterPro 1.441E-3 5.566E-3 2.797E-2
1.224E-1
 1 3
22 IPR007599 DER1 InterPro 1.441E-3 5.566E-3 2.797E-2
1.224E-1
 1 3
23 SM00580 PUG SMART 2.400E-3 7.895E-3 3.968E-2
2.040E-1
 1 5
24 IPR018391 PQQ beta propeller repeat InterPro 2.879E-3 7.895E-3 3.968E-2
2.447E-1
 1 6
25 2.140.10.10 - Gene3D 2.879E-3 7.895E-3 3.968E-2
2.447E-1
 1 6
26 IPR002372 PQQ repeat InterPro 2.879E-3 7.895E-3 3.968E-2
2.447E-1
 1 6
27 IPR027295 Quinoprotein ADH-like fam InterPro 2.879E-3 7.895E-3 3.968E-2
2.447E-1
 1 6
28 SM00564 PQQ SMART 2.879E-3 7.895E-3 3.968E-2
2.447E-1
 1 6
29 PF06623 MHC I C Pfam 2.879E-3 7.895E-3 3.968E-2
2.447E-1
 1 6
30 IPR018997 PUB domain InterPro 2.879E-3 7.895E-3 3.968E-2
2.447E-1
 1 6
31 IPR010579 MHC I a C InterPro 2.879E-3 7.895E-3 3.968E-2
2.447E-1
 1 6
32 IPR002194 Chaperonin TCP-1 CS InterPro 4.316E-3 1.072E-2
5.390E-2
3.669E-1
 1 9
33 IPR001844 Chaprnin Cpn60 InterPro 4.316E-3 1.072E-2
5.390E-2
3.669E-1
 1 9
34 IPR013320 ConA-like dom InterPro 4.639E-3 1.072E-2
5.390E-2
3.943E-1
 2 219
35 IPR017998 Chaperone TCP-1 InterPro 4.795E-3 1.072E-2
5.390E-2
4.075E-1
 1 10
36 PS00751 TCP1 2 PROSITE 4.795E-3 1.072E-2
5.390E-2
4.075E-1
 1 10
37 PS00995 TCP1 3 PROSITE 4.795E-3 1.072E-2
5.390E-2
4.075E-1
 1 10
38 PS00750 TCP1 1 PROSITE 4.795E-3 1.072E-2
5.390E-2
4.075E-1
 1 10
39 3.30.260.10 - Gene3D 5.273E-3 1.121E-2
5.631E-2
4.482E-1
 1 11
40 IPR027410 TCP-1-like intermed InterPro 5.273E-3 1.121E-2
5.631E-2
4.482E-1
 1 11
41 2.60.34.10 - Gene3D 5.751E-3 1.164E-2
5.850E-2
4.888E-1
 1 12
42 IPR029047 HSP70 peptide-bd InterPro 5.751E-3 1.164E-2
5.850E-2
4.888E-1
 1 12
43 1.20.1270.10 - Gene3D 6.229E-3 1.177E-2
5.913E-2
5.295E-1
 1 13
44 IPR029048 HSP70 C InterPro 6.229E-3 1.177E-2
5.913E-2
5.295E-1
 1 13
45 IPR018181 Heat shock 70 CS InterPro 6.229E-3 1.177E-2
5.913E-2
5.295E-1
 1 13
46 IPR027413 GROEL-like equatorial InterPro 6.707E-3 1.197E-2
6.018E-2
5.701E-1
 1 14
47 1.10.560.10 - Gene3D 6.707E-3 1.197E-2
6.018E-2
5.701E-1
 1 14
48 PF00118 Cpn60 TCP1 Pfam 7.184E-3 1.197E-2
6.018E-2
6.107E-1
 1 15
49 3.50.7.10 - Gene3D 7.184E-3 1.197E-2
6.018E-2
6.107E-1
 1 15
50 IPR027409 GroEL-like apical dom InterPro 7.184E-3 1.197E-2
6.018E-2
6.107E-1
 1 15
Show 45 more annotations

7: Pathway [Display Chart] 9 input genes in category / 80 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269194 Antigen Presentation: Folding, assembly and peptide loading of class I MHC BioSystems: REACTOME 2.673E-12 2.139E-10 1.062E-9 2.139E-10 5 25
2 83074 Antigen processing and presentation BioSystems: KEGG 9.804E-10 3.922E-8 1.947E-7 7.843E-8 5 77
3 167325 Protein processing in endoplasmic reticulum BioSystems: KEGG 4.788E-8 1.277E-6 6.340E-6 3.831E-6 5 166
4 1269124 Virus Assembly and Release BioSystems: REACTOME 4.645E-7 7.433E-6 3.691E-5 3.716E-5 2 2
5 1269125 Assembly of Viral Components at the Budding Site BioSystems: REACTOME 4.645E-7 7.433E-6 3.691E-5 3.716E-5 2 2
6 1268722 N-glycan trimming in the ER and Calnexin/Calreticulin cycle BioSystems: REACTOME 1.843E-6 2.457E-5 1.220E-4 1.474E-4 3 36
7 153910 Phagosome BioSystems: KEGG 2.703E-6 2.790E-5 1.385E-4 2.163E-4 4 154
8 1269192 Class I MHC mediated antigen processing & presentation BioSystems: REACTOME 2.790E-6 2.790E-5 1.385E-4 2.232E-4 5 376
9 1268758 ATF6 (ATF6-alpha) activates chaperone genes BioSystems: REACTOME 2.546E-5 2.149E-4 1.067E-3 2.037E-3 2 11
10 1269197 ER-Phagosome pathway BioSystems: REACTOME 2.686E-5 2.149E-4 1.067E-3 2.149E-3 3 87
11 1268714 Asparagine N-linked glycosylation BioSystems: REACTOME 3.094E-5 2.187E-4 1.086E-3 2.476E-3 4 285
12 1268756 Unfolded Protein Response (UPR) BioSystems: REACTOME 3.281E-5 2.187E-4 1.086E-3 2.625E-3 3 93
13 1268757 ATF6 (ATF6-alpha) activates chaperones BioSystems: REACTOME 3.609E-5 2.221E-4 1.103E-3 2.887E-3 2 13
14 1269195 Antigen processing-Cross presentation BioSystems: REACTOME 4.456E-5 2.546E-4 1.264E-3 3.564E-3 3 103
15 1268723 Calnexin/calreticulin cycle BioSystems: REACTOME 1.615E-4 8.615E-4 4.278E-3 1.292E-2 2 27
16 373901 HTLV-I infection BioSystems: KEGG 6.585E-4 3.293E-3 1.635E-2
5.268E-2
 3 256
17 1268759 IRE1alpha activates chaperones BioSystems: REACTOME 7.780E-4 3.661E-3 1.818E-2
6.224E-2
 2 59
18 835410 Thyroid hormone synthesis BioSystems: KEGG 1.221E-3 5.428E-3 2.695E-2
9.770E-2
 2 74
19 1269901 Scavenging by Class F Receptors BioSystems: REACTOME 4.330E-3 1.823E-2
9.054E-2
3.464E-1
 1 6
20 1269109 Influenza Life Cycle BioSystems: REACTOME 4.721E-3 1.888E-2
9.377E-2
3.777E-1
 2 147
21 1269108 Influenza Infection BioSystems: REACTOME 5.434E-3 2.070E-2
1.028E-1
4.347E-1
 2 158
22 1268698 Folding of actin by CCT/TriC BioSystems: REACTOME 7.208E-3 2.568E-2
1.275E-1
5.766E-1
 1 10
23 377873 Herpes simplex infection BioSystems: KEGG 7.382E-3 2.568E-2
1.275E-1
5.905E-1
 2 185
24 1269198 Endosomal/Vacuolar pathway BioSystems: REACTOME 8.644E-3 2.881E-2
1.431E-1
6.915E-1
 1 12
25 413361 N-glycan precursor biosynthesis BioSystems: KEGG 1.008E-2 3.225E-2
1.601E-1
8.063E-1
 1 14
26 1269899 Scavenging by Class A Receptors BioSystems: REACTOME 1.508E-2 4.641E-2
2.305E-1
1.000E0
 1 21
27 83041 Protein export BioSystems: KEGG 1.651E-2 4.892E-2
2.429E-1
1.000E0
 1 23
Show 22 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 2873 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 22013210 The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Pubmed 3.155E-14 9.064E-11 7.741E-10 9.064E-11 5 31
2 9545232 ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly. Pubmed 2.983E-13 4.285E-10 3.660E-9 8.570E-10 4 10
3 17090218 Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. Pubmed 1.421E-12 1.361E-9 1.162E-8 4.083E-9 4 14
4 11765911 The measles virus (MV) glycoproteins interact with cellular chaperones in the endoplasmic reticulum and MV infection upregulates chaperone expression. Pubmed 9.047E-12 6.498E-9 5.550E-8 2.599E-8 3 3
5 15677452 Soluble tyrosinase is an endoplasmic reticulum (ER)-associated degradation substrate retained in the ER by calreticulin and BiP/GRP78 and not calnexin. Pubmed 3.618E-11 1.485E-8 1.268E-7 1.040E-7 3 4
6 12383251 Association of the thyrotropin receptor with calnexin, calreticulin and BiP. Efects on the maturation of the receptor. Pubmed 3.618E-11 1.485E-8 1.268E-7 1.040E-7 3 4
7 20520781 Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling. Pubmed 3.618E-11 1.485E-8 1.268E-7 1.040E-7 3 4
8 11823531 Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading. Pubmed 3.165E-10 1.137E-7 9.707E-7 9.093E-7 3 7
9 16847323 GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Pubmed 5.063E-10 1.616E-7 1.380E-6 1.455E-6 3 8
10 17913437 Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouse. Pubmed 7.594E-10 2.182E-7 1.863E-6 2.182E-6 3 9
11 22961085 c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy. Pubmed 1.085E-9 2.833E-7 2.420E-6 3.117E-6 3 10
12 19139267 Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. Pubmed 1.598E-8 3.533E-6 3.017E-5 4.592E-5 3 23
13 25009997 Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity. Pubmed 1.598E-8 3.533E-6 3.017E-5 4.592E-5 3 23
14 28474670 Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy. Pubmed 1.827E-8 3.748E-6 3.201E-5 5.248E-5 3 24
15 27462432 A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Pubmed 3.071E-8 5.065E-6 4.326E-5 8.824E-5 4 153
16 19136429 Hepatic lipase maturation: a partial proteome of interacting factors. Pubmed 3.661E-8 5.065E-6 4.326E-5 1.052E-4 3 30
17 17215244 Purification and identification of G protein-coupled receptor protein complexes under native conditions. Pubmed 4.053E-8 5.065E-6 4.326E-5 1.165E-4 3 31
18 27375898 HIV-host interactome revealed directly from infected cells. Pubmed 4.917E-8 5.065E-6 4.326E-5 1.413E-4 4 172
19 16467570 Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum. Pubmed 4.936E-8 5.065E-6 4.326E-5 1.418E-4 2 2
20 14732231 Differential downregulation of endoplasmic reticulum-residing chaperones calnexin and calreticulin in human metastatic melanoma. Pubmed 4.936E-8 5.065E-6 4.326E-5 1.418E-4 2 2
21 27566407 Proteomic analysis reveals aberrant expression of CALR and HSPA5 in thyroid tissues of Graves' disease. Pubmed 4.936E-8 5.065E-6 4.326E-5 1.418E-4 2 2
22 23575540 [The effect on BiP regulation of IRE1a promoter transcription activity and protein expression]. Pubmed 4.936E-8 5.065E-6 4.326E-5 1.418E-4 2 2
23 12727205 Compromised calnexin function in calreticulin-deficient cells. Pubmed 4.936E-8 5.065E-6 4.326E-5 1.418E-4 2 2
24 8550632 Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexin. Pubmed 4.936E-8 5.065E-6 4.326E-5 1.418E-4 2 2
25 26388295 Calreticulin is required for development of the cumulus oocyte complex and female fertility. Pubmed 4.936E-8 5.065E-6 4.326E-5 1.418E-4 2 2
26 14731400 Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control. Pubmed 4.936E-8 5.065E-6 4.326E-5 1.418E-4 2 2
27 12637535 Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha. Pubmed 4.936E-8 5.065E-6 4.326E-5 1.418E-4 2 2
28 23816533 IRE1α dissociates with BiP and inhibits ER stress-mediated apoptosis in cartilage development. Pubmed 4.936E-8 5.065E-6 4.326E-5 1.418E-4 2 2
29 26816051 The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. Pubmed 8.233E-8 8.157E-6 6.966E-5 2.365E-4 3 39
30 27751915 Defining the Na(+)/H(+) exchanger NHE1 interactome in triple-negative breast cancer cells. Pubmed 1.366E-7 8.681E-6 7.414E-5 3.926E-4 3 46
31 29198525 A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
32 25692299 Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
33 17202325 The varicellovirus-encoded TAP inhibitor UL49.5 regulates the presentation of CTL epitopes by Qa-1b1. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
34 27283502 Endoplasmic reticulum stress in mouse decidua during early pregnancy. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
35 15383281 A polypeptide binding conformation of calreticulin is induced by heat shock, calcium depletion, or by deletion of the C-terminal acidic region. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
36 28618969 Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
37 11795871 Chaperone interactions of the metalloproteinase meprin A in the secretory or proteasomal-degradative pathway. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
38 10461883 Calnexin and the immunoglobulin binding protein (BiP) coimmunoprecipitate with AMPA receptors. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
39 11751874 The prosequence of human lactase-phlorizin hydrolase modulates the folding of the mature enzyme. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
40 12052826 Localization of the lectin, ERp57 binding, and polypeptide binding sites of calnexin and calreticulin. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
41 8662691 The glut 1 glucose transporter interacts with calnexin and calreticulin. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
42 9312001 Promotion of transferrin folding by cyclic interactions with calnexin and calreticulin. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
43 24810055 Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
44 15236594 ER-60 domains responsible for interaction with calnexin and calreticulin. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
45 22242185 Trafficking-deficient G572R-hERG and E637K-hERG activate stress and clearance pathways in endoplasmic reticulum. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
46 10364189 Molecular chaperones stimulate the functional expression of the cocaine-sensitive serotonin transporter. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
47 19054761 Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
48 22446326 Binding of human BiP to the ER stress transducers IRE1 and PERK requires ATP. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
49 17728248 Endoplasmic reticulum chaperones stabilize nicotinic receptor subunits and regulate receptor assembly. Pubmed 1.481E-7 8.681E-6 7.414E-5 4.254E-4 2 3
50 26641092 The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells. Pubmed 1.838E-7 1.056E-5 9.021E-5 5.282E-4 4 239
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 1055 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:HLA-A HLA-A interactions 4.956E-10 5.229E-7 3.942E-6 5.229E-7 5 95
2 int:APOB APOB interactions 2.189E-8 1.155E-5 8.705E-5 2.309E-5 4 66
3 int:HLA-B HLA-B interactions 6.420E-8 1.813E-5 1.367E-4 6.773E-5 4 86
4 int:F8 F8 interactions 8.768E-8 1.813E-5 1.367E-4 9.251E-5 3 19
5 int:CANX CANX interactions 9.710E-8 1.813E-5 1.367E-4 1.024E-4 5 271
6 int:PDIA2 PDIA2 interactions 1.031E-7 1.813E-5 1.367E-4 1.088E-4 3 20
7 int:TCTN3 TCTN3 interactions 2.187E-7 3.296E-5 2.485E-4 2.307E-4 5 319
8 int:GANAB GANAB interactions 2.548E-7 3.360E-5 2.533E-4 2.688E-4 4 121
9 int:ACP5 ACP5 interactions 3.298E-7 3.866E-5 2.915E-4 3.479E-4 3 29
10 int:ERN1 ERN1 interactions 4.473E-7 4.719E-5 3.558E-4 4.719E-4 3 32
11 int:WNT7A WNT7A interactions 5.394E-7 5.174E-5 3.900E-4 5.691E-4 3 34
12 int:CALR CALR interactions 6.366E-7 5.221E-5 3.936E-4 6.716E-4 4 152
13 int:LIPC LIPC interactions 6.433E-7 5.221E-5 3.936E-4 6.787E-4 3 36
14 int:PDIA3 PDIA3 interactions 8.014E-7 6.039E-5 4.553E-4 8.455E-4 4 161
15 int:TSHR TSHR interactions 1.110E-6 7.806E-5 5.885E-4 1.171E-3 3 43
16 int:TAP1 TAP1 interactions 1.191E-6 7.852E-5 5.920E-4 1.256E-3 3 44
17 int:LCT LCT interactions 1.378E-6 8.268E-5 6.233E-4 1.454E-3 2 4
18 int:B2M B2M interactions 1.457E-6 8.268E-5 6.233E-4 1.537E-3 3 47
19 int:HSP90B1 HSP90B1 interactions 1.489E-6 8.268E-5 6.233E-4 1.571E-3 4 188
20 int:RPN1 RPN1 interactions 1.723E-6 9.087E-5 6.851E-4 1.817E-3 4 195
21 int:SERPINA1 SERPINA1 interactions 2.765E-6 1.389E-4 1.047E-3 2.917E-3 3 58
22 int:SEL1L SEL1L interactions 3.385E-6 1.579E-4 1.191E-3 3.571E-3 3 62
23 int:DPEP3 DPEP3 interactions 3.443E-6 1.579E-4 1.191E-3 3.632E-3 2 6
24 int:EDEM3 EDEM3 interactions 3.907E-6 1.717E-4 1.295E-3 4.121E-3 3 65
25 int:PRKCSH PRKCSH interactions 4.681E-6 1.975E-4 1.489E-3 4.939E-3 3 69
26 int:CD1D CD1D interactions 6.423E-6 2.526E-4 1.904E-3 6.776E-3 2 8
27 int:CDC73 CDC73 interactions 6.465E-6 2.526E-4 1.904E-3 6.820E-3 4 272
28 int:TCTN2 TCTN2 interactions 6.948E-6 2.618E-4 1.974E-3 7.330E-3 4 277
29 int:SUMO4 SUMO4 interactions 7.320E-6 2.663E-4 2.008E-3 7.723E-3 3 80
30 int:HLA-C HLA-C interactions 9.104E-6 3.202E-4 2.414E-3 9.605E-3 3 86
31 int:TG TG interactions 1.032E-5 3.442E-4 2.595E-3 1.088E-2 2 10
32 int:PTPRN PTPRN interactions 1.044E-5 3.442E-4 2.595E-3 1.101E-2 3 90
33 int:ST3GAL2 ST3GAL2 interactions 1.261E-5 4.030E-4 3.038E-3 1.330E-2 2 11
34 int:INHA INHA interactions 1.512E-5 4.693E-4 3.538E-3 1.596E-2 2 12
35 int:SYVN1 SYVN1 interactions 1.566E-5 4.722E-4 3.560E-3 1.653E-2 3 103
36 int:RCN1 RCN1 interactions 1.707E-5 5.004E-4 3.772E-3 1.801E-2 3 106
37 int:FUCA2 FUCA2 interactions 1.787E-5 5.095E-4 3.841E-3 1.885E-2 2 13
38 int:ERLIN2 ERLIN2 interactions 1.961E-5 5.363E-4 4.043E-3 2.069E-2 3 111
39 int:FAM187B FAM187B interactions 2.084E-5 5.363E-4 4.043E-3 2.199E-2 2 14
40 int:SLC6A4 SLC6A4 interactions 2.084E-5 5.363E-4 4.043E-3 2.199E-2 2 14
41 int:ETFBKMT ETFBKMT interactions 2.084E-5 5.363E-4 4.043E-3 2.199E-2 2 14
42 int:CPA5 CPA5 interactions 2.404E-5 6.039E-4 4.553E-3 2.536E-2 2 15
43 int:CD3D CD3D interactions 2.747E-5 6.682E-4 5.038E-3 2.898E-2 2 16
44 int:U2AF2 U2AF2 interactions 2.787E-5 6.682E-4 5.038E-3 2.940E-2 4 394
45 int:TCTN1 TCTN1 interactions 2.866E-5 6.720E-4 5.066E-3 3.024E-2 3 126
46 int:DERL1 DERL1 interactions 2.935E-5 6.731E-4 5.074E-3 3.096E-2 3 127
47 int:AMFR AMFR interactions 3.147E-5 7.064E-4 5.326E-3 3.320E-2 3 130
48 int:TAPBP TAPBP interactions 3.500E-5 7.537E-4 5.682E-3 3.693E-2 2 18
49 int:HLA-G HLA-G interactions 3.500E-5 7.537E-4 5.682E-3 3.693E-2 2 18
50 int:LRP1 LRP1 interactions 3.762E-5 7.935E-4 5.982E-3 3.969E-2 3 138
Show 45 more annotations

10: Cytoband [Display Chart] 9 input genes in category / 8 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6p21.3 6p21.3 1.905E-3 1.123E-2 3.052E-2 1.524E-2 2 257
2 19p13.3-p13.2 19p13.3-p13.2 3.630E-3 1.123E-2 3.052E-2 2.904E-2 1 14
3 1p21.3 1p21.3 5.957E-3 1.123E-2 3.052E-2 4.766E-2 1 23
4 5q35 5q35 6.215E-3 1.123E-2 3.052E-2 4.972E-2 1 24
5 17q24.2 17q24.2 8.022E-3 1.123E-2 3.052E-2
6.417E-2
 1 31
6 9q33.3 9q33.3 9.568E-3 1.123E-2 3.052E-2
7.654E-2
 1 37
7 8q24.13 8q24.13 9.825E-3 1.123E-2 3.052E-2
7.860E-2
 1 38
8 7p11.2 7p11.2 1.803E-2 1.803E-2 4.901E-2
1.443E-1
 1 70
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 52 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 6 input genes in category / 7 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 449 UDP-N-acetylglucosaminyltransferase subunits|OTU domain containing|Tudor domain containing genenames.org 6.595E-4 4.616E-3 1.197E-2 4.616E-3 1 2
2 806 ATP binding cassette subfamily B genenames.org 3.623E-3 7.832E-3 2.031E-2 2.536E-2 1 11
3 926 Rhomboid family genenames.org 4.609E-3 7.832E-3 2.031E-2 3.226E-2 1 14
4 587 Chaperonins genenames.org 4.937E-3 7.832E-3 2.031E-2 3.456E-2 1 15
5 583 Heat shock 70kDa proteins genenames.org 5.594E-3 7.832E-3 2.031E-2 3.916E-2 1 17
6 591 Histocompatibility complex|C1-set domain containing genenames.org 1.377E-2 1.442E-2 3.740E-2
9.641E-2
 1 42
7 588 Histocompatibility complex|C1-set domain containing genenames.org 1.442E-2 1.442E-2 3.740E-2
1.010E-1
 1 44
Show 2 more annotations

13: Coexpression [Display Chart] 9 input genes in category / 1287 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20460173-ImmPortAntigenProcessingandPresentation Human Immune Kong10 148genes ImmPort AntigenProcessingandPresentation GeneSigDB 8.675E-10 1.116E-6 8.639E-6 1.116E-6 5 138
2 17191107-Table1 Human Lung not cancer Gambardella06 38genes GeneSigDB 2.421E-7 1.558E-4 1.205E-3 3.115E-4 3 34
3 M7950 Genes down-regulated in bone marrow-derived macrophages with STAT6 [GeneID=6778] knockout treated with rosiglitazone [PubChem=77999]: control versus IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 6.469E-7 1.913E-4 1.480E-3 8.325E-4 4 199
4 M5924 Genes up-regulated through activation of mTORC1 complex. MSigDB H: Hallmark Gene Sets (v6.0) 6.599E-7 1.913E-4 1.480E-3 8.493E-4 4 200
5 M8341 Antigen processing and presentation genes down-regulated in JY cells (B lymphocytes) treated with trichostatin A (TSA) [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.431E-7 1.913E-4 1.480E-3 9.564E-4 3 49
6 M4517 Genes up-regulated in multiple myeloma (MM) compared to normal plasma cells from the patient's identical twin. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.420E-6 7.336E-4 5.676E-3 4.401E-3 3 81
7 12969976-Table1 Human Myeloma Munshi04 93genes GeneSigDB 4.860E-6 8.460E-4 6.546E-3 6.255E-3 3 91
8 M13936 Genes down-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.259E-6 8.460E-4 6.546E-3 6.768E-3 4 337
9 M5922 Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum. MSigDB H: Hallmark Gene Sets (v6.0) 9.327E-6 1.334E-3 1.032E-2 1.200E-2 3 113
10 M5792 Genes with increased copy number that correlates with increased expression across six different lung adenocarcinoma cell lines. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.635E-5 3.678E-3 2.846E-2 4.678E-2 3 178
11 M12104 Genes down-regulated in BJAB cells (B-lymphoma) after leucine [PubChem=857] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.211E-5 3.678E-3 2.846E-2
5.419E-2
 3 187
12 M8960 Genes down-regulated in lymph node from aged PPARG [GeneID=5468] knockout mice: T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 5.068E-5 3.678E-3 2.846E-2
6.522E-2
 3 199
13 M9023 Genes up-regulated in CD69- KRLG1- [GeneID=969;10219] T reg: SELL high [GeneID=6402] versus SELL low [GeneID=6402]. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 3.678E-3 2.846E-2
6.620E-2
 3 200
14 M8982 Genes down-regulated in CD4 [GeneID=920] T cells over-expressing FOXP3 [GeneID=50943] and PPARg1 form of PPARG [GeneID=5468]: untreated versus pioglitazone [PubChem=4829]. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 3.678E-3 2.846E-2
6.620E-2
 3 200
15 M4666 Genes up-regulated in comparison of untreated CD8 T cells versus CD8 T cells treated with leukocyte costimulatory blockade antibodies. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 3.678E-3 2.846E-2
6.620E-2
 3 200
16 M4349 Genes up-regulated in comparison of lung tissue from wild type mice versus that from TLR4 [GeneID=7099] deficient animals. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 3.678E-3 2.846E-2
6.620E-2
 3 200
17 M9020 Genes down-regulated in lymphoid primed multipotent progenitors: wildtype versus LYL1 [GeneID=4066] knockout. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 3.678E-3 2.846E-2
6.620E-2
 3 200
18 M3095 Genes down-regulated in comparison of healthy B cells versus systemic lupus erythematosus B cells. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 3.678E-3 2.846E-2
6.620E-2
 3 200
19 M17363 Immune response genes up-regulated in zenograft tumors formed by SNU-601 cells (gastric cancer) made to express LRRC3B [GeneID=116135]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.818E-5 3.744E-3 2.897E-2
7.488E-2
 2 30
20 18757430-SuppTable3 Human StemCell Kim08 30genes GeneSigDB 5.818E-5 3.744E-3 2.897E-2
7.488E-2
 2 30
21 M19666 Genes down-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.290E-5 3.855E-3 2.983E-2
8.096E-2
 3 214
22 M10292 Genes up-regulated in MCF7-ADR cell line (breast cancer) resistant to docetaxel [PubChem=148124]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.497E-5 4.386E-3 3.394E-2
9.649E-2
 2 34
23 17935676-Table5 Human Lung Fu07 36genes GeneSigDB 8.416E-5 4.709E-3 3.644E-2
1.083E-1
 2 36
24 M8323 Up-regulated in GHOST(3)CXCR4 cells (osteosarcoma) upon ectopic expression of ILF3 [GeneID=3609]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.387E-5 5.034E-3 3.895E-2
1.208E-1
 2 38
25 17409444-Table1 Human Pancreas Cui07 63genes GeneSigDB 1.441E-4 7.418E-3
5.739E-2
1.854E-1
 2 47
26 M8349 Genes down-regulated in chondrosarcoma and ovarian carcinoma cell lines which developed resistance to trabectedin [PubChem=3199]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.567E-4 7.756E-3
6.001E-2
2.017E-1
 2 49
27 15026349-Table3a Human Lung Carson04 56genes GeneSigDB 1.698E-4 8.094E-3
6.263E-2
2.185E-1
 2 51
28 M13763 Genes up-regulated in primary hepatocytes and Hep3B (hepatocyte) cells in response to IFNA [GeneID=3439]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.766E-4 8.116E-3
6.280E-2
2.272E-1
 2 52
29 M9780 Representative genes up-regulated in MiaPaCa2 cells (pancreatic cancer) under glucose-deprived conditions. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.353E-4 1.044E-2
8.080E-2
3.028E-1
 2 60
30 M7488 Antigen processing and presentation genes up-regulated in JY cells (B lymphocytes) treated with TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.678E-4 1.149E-2
8.889E-2
3.446E-1
 2 64
31 15661559-Table3 Human Ovarian Marchini05 70genes GeneSigDB 3.023E-4 1.252E-2
9.688E-2
3.891E-1
 2 68
32 M8365 Genes commonly up-regulated in undifferentiated cancer relative to well-differentiated cancer, based on the meta-analysis of the OncoMine gene expression database. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.113E-4 1.252E-2
9.688E-2
4.007E-1
 2 69
33 M15615 Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon gamma for 6 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.296E-4 1.286E-2
9.947E-2
4.242E-1
 2 71
34 M3652 Genes up-regulated in HT1080 cells (fibrosarcoma) by treatment with interferon alpha for 6 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.581E-4 1.355E-2
1.049E-1
4.608E-1
 2 74
35 M15368 Top 100 probe sets for pediatric acute myeloid leukemia (AML) subtype t(15;17): has PML RARA fusion [GeneID=5371;5914]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.876E-4 1.422E-2
1.100E-1
4.989E-1
 2 77
36 M4552 Genes up-regulated in plasma cells compared with B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.978E-4 1.422E-2
1.100E-1
5.119E-1
 2 78
37 M4665 Genes down-regulated in glomeruli of kidneys from patients with diabetic nephropathy (type 2 diabetes mellitus). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.062E-4 1.761E-2
1.362E-1
6.514E-1
 3 434
38 M15565 Up-regulated at 24 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v6.0) 5.649E-4 1.913E-2
1.480E-1
7.271E-1
 2 93
39 12631704-table1 Human StemCell Qi03 534genes GeneSigDB 6.668E-4 1.936E-2
1.498E-1
8.581E-1
 3 477
40 M13453 Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon beta for 6 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.790E-4 1.936E-2
1.498E-1
8.739E-1
 2 102
41 M5389 Genes whose expression increases with age in normal kidney. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.041E-4 1.936E-2
1.498E-1
9.061E-1
 3 486
42 M19016 Genes down-regulated in erythroid progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [GeneID=6223]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.211E-4 1.936E-2
1.498E-1
9.280E-1
 3 490
43 M19630 Up-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v6.0) 9.378E-4 1.936E-2
1.498E-1
1.000E0
 2 120
44 M18550 Up-regulated genes in MDA-MB-435 cells (breast cancer) undergoing G2/M arrest after treatment with 2-methoxyestradiol (2ME2)[PubChem=1573]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.848E-4 1.936E-2
1.498E-1
1.000E0
 2 123
45 M12272 Genes up-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668], a DNA hypomethylating agent similar to azacitidine [PubChem=9444]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.033E-3 1.936E-2
1.498E-1
1.000E0
 2 126
46 M1447 Genes defining proliferation and self renewal potential of the bipotential myeloid cell line FDB. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.082E-3 1.936E-2
1.498E-1
1.000E0
 2 129
47 12782583-Table3 Human Colon Daoud03 167genes GeneSigDB 1.291E-3 1.936E-2
1.498E-1
1.000E0
 2 141
48 16081686-SuppTable2 Human Lymphoma Tome05 357genes GeneSigDB 1.556E-3 1.936E-2
1.498E-1
1.000E0
 2 155
49 M5657 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with acute influenza infection versus PBMC from patients with acute S. pneumoniae infection. MSigDB C7: Immunologic Signatures (v6.0) 1.846E-3 1.936E-2
1.498E-1
1.000E0
 2 169
50 M8467 Genes up-regulated in peripheral blood mononuclear cells (PBMC) from sickle cell disease patients compared to those from healthy subjects. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.113E-3 1.936E-2
1.498E-1
1.000E0
 2 181
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 9 input genes in category / 832 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney NephrogenicRest Wilms U U/Kidney NephrogenicRest Wilms U20 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney NephrogenicRest Wilms U U/Kidney NephrogenicRest Wilms U20 Adult, Development, and Cancer types 7.360E-7 6.124E-4 4.471E-3 6.124E-4 4 194
2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal fetal kidney Normal cell/Kidney Normal fetal kidney T8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal fetal kidney Normal cell/Kidney Normal fetal kidney T8 Adult, Development, and Cancer types 1.263E-5 3.739E-3 2.730E-2 1.051E-2 3 118
3 Sample Type by Project: Shred 1/TCGA-Uvea/Uveal Melanoma/Epithelioid Cell/2/2 Sample Type by Project: Shred 1/TCGA-Uvea/Uveal Melanoma/Epithelioid Cell/2/2 TCGA-Uvea 3.202E-5 3.739E-3 2.730E-2 2.664E-2 3 161
4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP PapRCC/Kidney Tumour RCC MNP PapRCC Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP PapRCC/Kidney Tumour RCC MNP PapRCC Adult, Development, and Cancer types 3.766E-5 3.739E-3 2.730E-2 3.133E-2 3 170
5 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Thymus/leukocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Thymus/leukocyte Tabula Muris Consortium 4.511E-5 3.739E-3 2.730E-2 3.753E-2 2 25
6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney F7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney F7 Adult, Development, and Cancer types 4.846E-5 3.739E-3 2.730E-2 4.032E-2 3 185
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell/Kidney Normal fetal kidney NK8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell/Kidney Normal fetal kidney NK8 Adult, Development, and Cancer types 5.412E-5 3.739E-3 2.730E-2 4.503E-2 3 192
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Normal fetal kidney MNP2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Normal fetal kidney MNP2 Adult, Development, and Cancer types 5.496E-5 3.739E-3 2.730E-2 4.573E-2 3 193
9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IN-U/Ureter Normal RCC IN-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IN-U/Ureter Normal RCC IN-U Adult, Development, and Cancer types 5.582E-5 3.739E-3 2.730E-2 4.644E-2 3 194
10 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/granulocyte monocyte progenitor cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/granulocyte monocyte progenitor cell Tabula Muris Consortium 5.582E-5 3.739E-3 2.730E-2 4.644E-2 3 194
11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Tumour VHL RCC MNP2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Tumour VHL RCC MNP2 Adult, Development, and Cancer types 5.668E-5 3.739E-3 2.730E-2 4.715E-2 3 195
12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U/Kidney Normal fetal kidney U-U/Kidney Normal fetal kidney U8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U/Kidney Normal fetal kidney U-U/Kidney Normal fetal kidney U8 Adult, Development, and Cancer types 5.668E-5 3.739E-3 2.730E-2 4.715E-2 3 195
13 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC1/Kidney Normal fetal kidney MNP RCC1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC1/Kidney Normal fetal kidney MNP RCC1 Adult, Development, and Cancer types 5.842E-5 3.739E-3 2.730E-2 4.861E-2 3 197
14 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype CD34+ Eo/B/Mast Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype CD34+ Eo/B/Mast Top 200 Genes 2.688E-4 1.552E-2
1.134E-1
2.236E-1
 3 330
15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IF-U/Ureter Normal Wilms IF-U/Ureter Normal Wilms IF21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IF-U/Ureter Normal Wilms IF-U/Ureter Normal Wilms IF21 Adult, Development, and Cancer types 2.821E-4 1.552E-2
1.134E-1
2.347E-1
 2 62
16 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype CD34+ Gran Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype CD34+ Gran Top 200 Genes 2.986E-4 1.552E-2
1.134E-1
2.484E-1
 3 342
17 10X Human 8K PBMC CD8 T cell Subtype CD8 T cell-GZMK CCL5 NKG7 Top 200 Genes 10X Human 8K PBMC CD8 T cell Subtype CD8 T cell-GZMK CCL5 NKG7 Top 200 Genes 3.359E-4 1.565E-2
1.143E-1
2.794E-1
 3 356
18 10X Human 8K PBMC T cell Subtype T cell-GZMK CCL5 NKG7 Top 200 Genes 10X Human 8K PBMC T cell Subtype T cell-GZMK CCL5 NKG7 Top 200 Genes 3.387E-4 1.565E-2
1.143E-1
2.818E-1
 3 357
19 10X Human 8K PBMC NK cells (GZMB, SPON2, GNLY) Subtype NK cells (GZMB, SPON2, GNLY)-NK cells subclass-0 (FGFBP2, GZMB, SPON2) Top 200 Genes 10X Human 8K PBMC NK cells (GZMB, SPON2, GNLY) Subtype NK cells (GZMB, SPON2, GNLY)-NK cells subclass-0 (FGFBP2, GZMB, SPON2) Top 200 Genes 4.225E-4 1.785E-2
1.303E-1
3.516E-1
 3 385
20 10X Human 68K PBMC CD4+/CD45RA+/CD25- Naive T Subtype CD4+/CD45RA+/CD25- Naive T-CD4+/CD45RA+/CD25- Naive T c6 Top 200 Genes 10X Human 68K PBMC CD4+/CD45RA+/CD25- Naive T Subtype CD4+/CD45RA+/CD25- Naive T-CD4+/CD45RA+/CD25- Naive T c6 Top 200 Genes 4.290E-4 1.785E-2
1.303E-1
3.569E-1
 3 387
21 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.2 Intermediate.2 Overall Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.2 Intermediate.2 Overall Top 100 Genes 6.614E-4 2.620E-2
1.913E-1
5.503E-1
 2 95
22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney B cell/Kidney Tumour Wilms B cell/Kidney Tumour Wilms IN13 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney B cell/Kidney Tumour Wilms B cell/Kidney Tumour Wilms IN13 Adult, Development, and Cancer types 9.502E-4 2.649E-2
1.934E-1
7.906E-1
 2 114
23 Sample Type by Project: Shred 1/TCGA-Kidney/Renal Cell Carcinoma/Kidney Chromophobe/7/2 Sample Type by Project: Shred 1/TCGA-Kidney/Renal Cell Carcinoma/Kidney Chromophobe/7/2 TCGA-Kidney 1.069E-3 2.649E-2
1.934E-1
8.898E-1
 2 121
24 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Normal PapRCC Th cell/Kidney Normal PapRCC IN4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Normal PapRCC Th cell/Kidney Normal PapRCC IN4 Adult, Development, and Cancer types 1.105E-3 2.649E-2
1.934E-1
9.192E-1
 2 123
25 gudmap kidney adult CortVasc Tie2 k4 1000 kidney adult CortVasc Tie2 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.387E-3 2.649E-2
1.934E-1
1.000E0
 2 138
26 gudmap kidney adult Mesangium Meis k3 500 kidney adult Mesangium Meis k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.407E-3 2.649E-2
1.934E-1
1.000E0
 2 139
27 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.2 Intermediate.2 Subtype int.2.5 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.2 Intermediate.2 Subtype int.2.5 Top 100 Genes 1.448E-3 2.649E-2
1.934E-1
1.000E0
 2 141
28 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Tumour Wilms Nephrogenesis/Kidney Tumour Wilms F4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Tumour Wilms Nephrogenesis/Kidney Tumour Wilms F4 Adult, Development, and Cancer types 1.530E-3 2.649E-2
1.934E-1
1.000E0
 2 145
29 gudmap developingLowerUrinaryTract adult ureter 1000 k1 DevelopingLowerUrinaryTract adult ureter emap-29479 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.615E-3 2.649E-2
1.934E-1
1.000E0
 2 149
30 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R-U/Kidney Normal fetal kidney R-U/Kidney Normal fetal kidney R8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R-U/Kidney Normal fetal kidney R-U/Kidney Normal fetal kidney R8 Adult, Development, and Cancer types 1.723E-3 2.649E-2
1.934E-1
1.000E0
 2 154
31 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.2 Intermediate.2 Subtype int.2.4 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.2 Intermediate.2 Subtype int.2.4 Top 100 Genes 1.904E-3 2.649E-2
1.934E-1
1.000E0
 2 162
32 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U/Kidney Normal fetal kidney U-U/Kidney Normal fetal kidney U6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U/Kidney Normal fetal kidney U-U/Kidney Normal fetal kidney U6 Adult, Development, and Cancer types 1.904E-3 2.649E-2
1.934E-1
1.000E0
 2 162
33 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.2 Intermediate.2 Subtype int.2.2 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.2 Intermediate.2 Subtype int.2.2 Top 100 Genes 1.998E-3 2.649E-2
1.934E-1
1.000E0
 2 166
34 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell Adult, Development, and Cancer types 1.998E-3 2.649E-2
1.934E-1
1.000E0
 2 166
35 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Rectal Adenocarcinoma/3/0 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Rectal Adenocarcinoma/3/0 TCGA-Colorectal 2.022E-3 2.649E-2
1.934E-1
1.000E0
 2 167
36 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-D/Kidney Tumour VHL RCC EN-D Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-D/Kidney Tumour VHL RCC EN-D Adult, Development, and Cancer types 2.060E-3 2.649E-2
1.934E-1
1.000E0
 1 5
37 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney CD8 T cell/Kidney Normal Wilms CD8 T cell/Kidney Normal Wilms IN10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney CD8 T cell/Kidney Normal Wilms CD8 T cell/Kidney Normal Wilms IN10 Adult, Development, and Cancer types 2.060E-3 2.649E-2
1.934E-1
1.000E0
 1 5
38 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/mature natural killer cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/mature natural killer cell Tabula Muris Consortium 2.094E-3 2.649E-2
1.934E-1
1.000E0
 2 170
39 Kidney10XCellRanger Six2TGC TSC1 P0 RV RV Overall Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 RV RV Overall Top 200 Genes 2.118E-3 2.649E-2
1.934E-1
1.000E0
 2 171
40 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Seminoma- NOS/2/1 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Seminoma- NOS/2/1 TCGA-Testes 2.192E-3 2.649E-2
1.934E-1
1.000E0
 2 174
41 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney F-U/Kidney Tumour Wilms F-U/Kidney Tumour Wilms F15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney F-U/Kidney Tumour Wilms F-U/Kidney Tumour Wilms F15 Adult, Development, and Cancer types 2.192E-3 2.649E-2
1.934E-1
1.000E0
 2 174
42 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.2 Intermediate.2 Subtype int.2.3 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.2 Intermediate.2 Subtype int.2.3 Top 100 Genes 2.192E-3 2.649E-2
1.934E-1
1.000E0
 2 174
43 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Tumour RCC Renal cell carcinoma/Kidney Tumour RCC T4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Tumour RCC Renal cell carcinoma/Kidney Tumour RCC T4 Adult, Development, and Cancer types 2.242E-3 2.649E-2
1.934E-1
1.000E0
 2 176
44 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Tumour RCC Th cell/Kidney Tumour RCC IN4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Tumour RCC Th cell/Kidney Tumour RCC IN4 Adult, Development, and Cancer types 2.242E-3 2.649E-2
1.934E-1
1.000E0
 2 176
45 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2-like/Kidney Tumour VHL RCC MNP2-like Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2-like/Kidney Tumour VHL RCC MNP2-like Adult, Development, and Cancer types 2.369E-3 2.649E-2
1.934E-1
1.000E0
 2 181
46 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell/Kidney Normal fetal kidney NK6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell/Kidney Normal fetal kidney NK6 Adult, Development, and Cancer types 2.395E-3 2.649E-2
1.934E-1
1.000E0
 2 182
47 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Normal-Medulla Wilms Fetus other/Kidney Normal-Medulla Wilms F9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Normal-Medulla Wilms Fetus other/Kidney Normal-Medulla Wilms F9 Adult, Development, and Cancer types 2.472E-3 2.649E-2
1.934E-1
1.000E0
 1 6
48 Kidney10XCellRanger Six2TGC E14 Endo Endo Overall Top 200 Genes Kidney10XCellRanger Six2TGC E14 Endo Endo Overall Top 200 Genes 2.473E-3 2.649E-2
1.934E-1
1.000E0
 2 185
49 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Tumour Wilms Fetus other/Kidney Tumour Wilms F9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Tumour Wilms Fetus other/Kidney Tumour Wilms F9 Adult, Development, and Cancer types 2.473E-3 2.649E-2
1.934E-1
1.000E0
 2 185
50 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour Wilms NK cell/Kidney Tumour Wilms NK9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour Wilms NK cell/Kidney Tumour Wilms NK9 Adult, Development, and Cancer types 2.499E-3 2.649E-2
1.934E-1
1.000E0
 2 186
Show 45 more annotations

15: Computational [Display Chart] 6 input genes in category / 89 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M4563 MODULE 355 Protein folding. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.313E-7 3.433E-5 1.741E-4 3.838E-5 3 29
2 M4634 MODULE 299 Genes in the cancer module 299. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.714E-7 3.433E-5 1.741E-4 6.866E-5 3 35
3 M9268 GNF2 INPP5D Neighborhood of INPP5D MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.660E-4 7.078E-3 3.590E-2 2.368E-2 2 43
4 M5267 GNF2 HLA-C Neighborhood of HLA-C MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.181E-4 7.078E-3 3.590E-2 2.831E-2 2 47
5 M17909 GNF2 CD53 Neighborhood of CD53 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.850E-4 8.633E-3 4.378E-2 4.317E-2 2 58
6 M19908 MORF NME2 Neighborhood of NME2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.369E-3 4.998E-2
2.535E-1
2.999E-1
 2 154
Show 1 more annotation

16: MicroRNA [Display Chart] 9 input genes in category / 487 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1253:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.607E-6 7.828E-4 5.297E-3 7.828E-4 3 195
2 hsa-miR-18a-5p:Functional MTI Functional MTI miRTarbase 3.898E-6 9.492E-4 6.423E-3 1.898E-3 3 262
3 hsa-miR-7161-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.754E-5 2.847E-3 1.926E-2 8.540E-3 2 51
4 hsa-miR-6126:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.317E-5 3.913E-3 2.648E-2 1.616E-2 2 70
5 hsa-miR-4493:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.017E-5 3.913E-3 2.648E-2 1.956E-2 2 77
6 hsa-miR-875-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.065E-5 6.070E-3 4.107E-2 3.928E-2 2 109
7 hsa-miR-668-3p:TargetScan hsa-miR-668-3p TargetScan 1.061E-4 6.070E-3 4.107E-2
5.166E-2
 2 125
8 hsa-miR-605-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.219E-4 6.070E-3 4.107E-2
5.936E-2
 2 134
9 hsa-miR-6879-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.312E-4 6.070E-3 4.107E-2
6.387E-2
 2 139
10 hsa-miR-6891-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.312E-4 6.070E-3 4.107E-2
6.387E-2
 2 139
11 hsa-miR-6773-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.427E-4 6.070E-3 4.107E-2
6.950E-2
 2 145
12 hsa-miR-4468:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.568E-4 6.070E-3 4.107E-2
7.636E-2
 2 152
13 hsa-miR-5582-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.781E-4 6.070E-3 4.107E-2
8.672E-2
 2 162
14 hsa-miR-5197-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.803E-4 6.070E-3 4.107E-2
8.779E-2
 2 163
15 hsa-miR-199a-5p:Non-Functional MTI Non-Functional MTI miRTarbase 1.870E-4 6.070E-3 4.107E-2
9.105E-2
 2 166
16 hsa-miR-6722-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.222E-4 6.505E-3 4.402E-2
1.082E-1
 2 181
17 hsa-miR-1909-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.271E-4 6.505E-3 4.402E-2
1.106E-1
 2 183
18 hsa-miR-4534:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.847E-4 7.369E-3 4.986E-2
1.387E-1
 2 205
19 hsa-miR-500b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.875E-4 7.369E-3 4.986E-2
1.400E-1
 2 206
20 hsa-miR-216a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.027E-4 9.338E-3
6.319E-2
1.961E-1
 2 244
21 hsa-miR-3681-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.027E-4 9.338E-3
6.319E-2
1.961E-1
 2 244
22 hsa-miR-6878-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.226E-4 9.355E-3
6.330E-2
2.058E-1
 2 250
23 hsa-miR-93-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.888E-4 1.011E-2
6.841E-2
2.380E-1
 2 269
24 hsa-miR-6716-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.982E-4 1.011E-2
6.841E-2
2.426E-1
 1 4
25 hsa-miR-4779:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.559E-4 1.083E-2
7.327E-2
2.707E-1
 2 287
26 hsa-miR-557:PITA hsa-miR-557:PITA TOP PITA 6.231E-4 1.084E-2
7.334E-2
3.035E-1
 2 304
27 hsa-miR-507:PITA hsa-miR-507:PITA TOP PITA 6.231E-4 1.084E-2
7.334E-2
3.035E-1
 2 304
28 hsa-miR-342-3p:Functional MTI Functional MTI miRTarbase 6.231E-4 1.084E-2
7.334E-2
3.035E-1
 2 304
29 hsa-miR-139-5p:TargetScan hsa-miR-139-5p TargetScan 6.686E-4 1.123E-2
7.598E-2
3.256E-1
 2 315
30 hsa-miR-212-5p:TargetScan hsa-miR-212-5p TargetScan 7.157E-4 1.162E-2
7.862E-2
3.486E-1
 2 326
31 hsa-miR-1288:mirSVR highEffct hsa-miR-1288:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.870E-4 1.216E-2
8.227E-2
3.833E-1
 2 342
32 hsa-miR-30e-5p:Functional MTI Functional MTI miRTarbase 8.100E-4 1.216E-2
8.227E-2
3.945E-1
 2 347
33 hsa-miR-765:Functional MTI Functional MTI miRTarbase 8.239E-4 1.216E-2
8.227E-2
4.012E-1
 2 350
34 hsa-miR-4695-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.197E-4 1.256E-2
8.497E-2
4.479E-1
 2 370
35 hsa-miR-6825-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.796E-4 1.256E-2
8.497E-2
4.771E-1
 2 382
36 hsa-miR-143-5p:Functional MTI Functional MTI miRTarbase 1.015E-3 1.256E-2
8.497E-2
4.945E-1
 2 389
37 hsa-miR-504-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.026E-3 1.256E-2
8.497E-2
4.996E-1
 2 391
38 hsa-miR-3135b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.041E-3 1.256E-2
8.497E-2
5.072E-1
 2 394
39 hsa-miR-3652:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.057E-3 1.256E-2
8.497E-2
5.148E-1
 2 397
40 hsa-miR-149-5p:Functional MTI Functional MTI miRTarbase 1.057E-3 1.256E-2
8.497E-2
5.148E-1
 2 397
41 hsa-miR-4430:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.057E-3 1.256E-2
8.497E-2
5.148E-1
 2 397
42 hsa-miR-3612:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.204E-3 1.383E-2
9.356E-2
5.863E-1
 2 424
43 hsa-miR-650:Functional MTI Functional MTI miRTarbase 1.221E-3 1.383E-2
9.356E-2
5.945E-1
 2 427
44 hsa-miR-939-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.289E-3 1.427E-2
9.656E-2
6.280E-1
 2 439
45 hsa-miR-2909:mirSVR highEffct hsa-miR-2909:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.319E-3 1.427E-2
9.656E-2
6.422E-1
 2 444
46 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 1.557E-3 1.580E-2
1.069E-1
7.582E-1
 2 483
47 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 1.557E-3 1.580E-2
1.069E-1
7.582E-1
 2 483
48 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 1.557E-3 1.580E-2
1.069E-1
7.582E-1
 2 483
49 hsa-miR-95-3p:Functional MTI Functional MTI miRTarbase 1.619E-3 1.598E-2
1.081E-1
7.882E-1
 1 13
50 hsa-miR-5698:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.640E-3 1.598E-2
1.081E-1
7.989E-1
 2 496
Show 45 more annotations

17: Drug [Display Chart] 9 input genes in category / 2002 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C007420 dihydroxyaluminum aminoacetate CTD 8.455E-10 1.693E-6 1.385E-5 1.693E-6 3 6
2 DB00025 Antihemophilic Factor Drug Bank 6.969E-9 6.976E-6 5.706E-5 1.395E-5 3 11
3 CID000448381 2hqu Stitch 1.727E-8 1.153E-5 9.428E-5 3.458E-5 5 247
4 CID005282055 C12063 Stitch 2.704E-7 1.353E-4 1.107E-3 5.414E-4 5 429
5 ctd:C026105 butylidenephthalide CTD 1.360E-6 4.522E-4 3.699E-3 2.723E-3 3 59
6 CID000123910 Kdel Sequence Stitch 1.581E-6 4.522E-4 3.699E-3 3.166E-3 3 62
7 CID000121907 EGTA-AM Stitch 1.581E-6 4.522E-4 3.699E-3 3.166E-3 3 62
8 ctd:C066185 tingenin B CTD 2.069E-6 5.176E-4 4.234E-3 4.141E-3 2 6
9 CID000006862 naphthalene acetic acid Stitch 3.171E-6 7.053E-4 5.769E-3 6.348E-3 3 78
10 ctd:C059873 sulfamethoxazole hydroxylamine CTD 4.961E-6 8.132E-4 6.652E-3 9.933E-3 2 9
11 ctd:C442478 N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide CTD 4.961E-6 8.132E-4 6.652E-3 9.933E-3 2 9
12 ctd:D011193 Potassium Iodide CTD 4.961E-6 8.132E-4 6.652E-3 9.933E-3 2 9
13 CID000003829 AC1L1GT5 Stitch 5.750E-6 8.132E-4 6.652E-3 1.151E-2 3 95
14 CID000002070 AC1L1CUL Stitch 6.200E-6 8.132E-4 6.652E-3 1.241E-2 2 10
15 ctd:D006143 Guanabenz CTD 6.200E-6 8.132E-4 6.652E-3 1.241E-2 2 10
16 CID000000897 H S Q Stitch 6.499E-6 8.132E-4 6.652E-3 1.301E-2 4 351
17 DB00031 Tenecteplase Drug Bank 7.577E-6 8.923E-4 7.298E-3 1.517E-2 2 11
18 ctd:D003603 Cytotoxins CTD 1.074E-5 1.195E-3 9.771E-3 2.150E-2 2 13
19 ctd:C004762 2,4-dichlorophenol CTD 1.253E-5 1.320E-3 1.080E-2 2.508E-2 2 14
20 CID000105082 AC1L2Y08 Stitch 1.475E-5 1.476E-3 1.208E-2 2.953E-2 4 432
21 CID000448904 sq A Stitch 1.871E-5 1.703E-3 1.393E-2 3.746E-2 2 17
22 ctd:C559087 SR 1078 CTD 1.871E-5 1.703E-3 1.393E-2 3.746E-2 2 17
23 ctd:C041711 St. Thomas' Hospital cardioplegic solution CTD 1.964E-5 1.707E-3 1.397E-2 3.931E-2 3 143
24 CID000002592 NSC625381 Stitch 2.047E-5 1.707E-3 1.397E-2 4.098E-2 3 145
25 ctd:C007262 deoxynivalenol CTD 2.287E-5 1.744E-3 1.426E-2 4.579E-2 4 483
26 ctd:C075773 4-phenylbutyric acid CTD 2.311E-5 1.744E-3 1.426E-2 4.626E-2 3 151
27 ctd:C043247 3-acetyldeoxynivalenol CTD 2.352E-5 1.744E-3 1.426E-2 4.708E-2 2 19
28 ctd:C012906 dihydrocapsaicin CTD 2.613E-5 1.868E-3 1.528E-2
5.230E-2
 2 20
29 ctd:D007460 Iodoacetamide CTD 2.887E-5 1.938E-3 1.585E-2
5.780E-2
 2 21
30 ctd:D016627 Oxidopamine CTD 2.904E-5 1.938E-3 1.585E-2
5.814E-2
 3 163
31 ctd:C555916 MitoTEMPO CTD 3.175E-5 1.986E-3 1.625E-2
6.357E-2
 2 22
32 CID000114821 SMX-HA Stitch 3.175E-5 1.986E-3 1.625E-2
6.357E-2
 2 22
33 CID000501390 N-nonyl-deoxygalactonojirimycin Stitch 3.477E-5 2.109E-3 1.725E-2
6.961E-2
 2 23
34 ctd:D044945 Proanthocyanidins CTD 3.792E-5 2.233E-3 1.826E-2
7.592E-2
 2 24
35 ctd:C006972 chloroacetic acid CTD 4.121E-5 2.292E-3 1.874E-2
8.250E-2
 2 25
36 ctd:C121465 6-methyl-2-(phenylethynyl)pyridine CTD 4.121E-5 2.292E-3 1.874E-2
8.250E-2
 2 25
37 ctd:C000499 ferric oxide CTD 4.806E-5 2.509E-3 2.053E-2
9.622E-2
 3 193
38 ctd:D011718 Pyrazinamide CTD 4.820E-5 2.509E-3 2.053E-2
9.649E-2
 2 27
39 ctd:D006710 Homocysteine CTD 4.956E-5 2.509E-3 2.053E-2
9.922E-2
 3 195
40 ctd:C587734 2,3,5-trichloro-6-phenyl-(1,4)benzoquinone CTD 5.189E-5 2.509E-3 2.053E-2
1.039E-1
 2 28
41 ctd:C077793 candesartan cilexetil CTD 5.189E-5 2.509E-3 2.053E-2
1.039E-1
 2 28
42 1954 UP Danazol [17230-88-5]; Up 200; 11.8uM; PC3; HG-U133A Broad Institute CMAP Up 5.265E-5 2.509E-3 2.053E-2
1.054E-1
 3 199
43 CID000439275 AC1L970Z Stitch 5.573E-5 2.594E-3 2.122E-2
1.116E-1
 2 29
44 CID000040600 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid Stitch 5.835E-5 2.655E-3 2.172E-2
1.168E-1
 3 206
45 ctd:D010168 Palmitates CTD 5.969E-5 2.656E-3 2.172E-2
1.195E-1
 2 30
46 CID000123237 CF3CO Stitch 6.380E-5 2.777E-3 2.271E-2
1.277E-1
 2 31
47 ctd:D002193 Cantharidin CTD 6.804E-5 2.898E-3 2.370E-2
1.362E-1
 2 32
48 ctd:C031280 pyrazole CTD 7.385E-5 3.080E-3 2.519E-2
1.479E-1
 3 223
49 ctd:C027235 gallium nitrate CTD 7.692E-5 3.143E-3 2.571E-2
1.540E-1
 2 34
50 ctd:D020126 Brefeldin A CTD 8.157E-5 3.266E-3 2.671E-2
1.633E-1
 2 35
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 338 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0268494 Oculocutaneous albinism type 1 DisGeNET Curated 4.141E-9 1.400E-6 8.961E-6 1.400E-6 3 7
2 C0278883 Metastatic melanoma DisGeNET BeFree 2.949E-5 4.983E-3 3.190E-2 9.966E-3 4 366
3 C0151744 Myocardial Ischemia DisGeNET Curated 5.102E-5 5.748E-3 3.680E-2 1.725E-2 4 421
4 C0151517 Complete atrioventricular block DisGeNET Curated 8.938E-5 7.553E-3 4.835E-2 3.021E-2 3 169
5 C0041341 Tuberous Sclerosis DisGeNET Curated 1.451E-4 9.636E-3
6.169E-2
 4.905E-2 3 199
6 C0270549 Generalized Anxiety Disorder DisGeNET BeFree 1.711E-4 9.636E-3
6.169E-2
5.782E-2
 2 36
7 C0001916 Albinism DisGeNET Curated 2.447E-4 1.034E-2
6.618E-2
8.271E-2
 2 43
8 C0014057 Japanese Encephalitis DisGeNET BeFree 2.447E-4 1.034E-2
6.618E-2
8.271E-2
 2 43
9 C4015596 MYASTHENIC SYNDROME, CONGENITAL, 15 DisGeNET Curated 5.554E-4 1.564E-2
1.001E-1
1.877E-1
 1 1
10 C0345916 Neoplasm of ampulla of Vater DisGeNET BeFree 5.554E-4 1.564E-2
1.001E-1
1.877E-1
 1 1
11 cv:CN226294 Myasthenic syndrome, congenital, without tubular aggregates Clinical Variations 5.554E-4 1.564E-2
1.001E-1
1.877E-1
 1 1
12 C0001432 Adenoma, Chromophobe DisGeNET BeFree 5.554E-4 1.564E-2
1.001E-1
1.877E-1
 1 1
13 C1096184 West Nile viral infection DisGeNET BeFree 8.684E-4 2.085E-2
1.335E-1
2.935E-1
 2 81
14 C0006413 Burkitt Lymphoma DisGeNET Curated 1.043E-3 2.085E-2
1.335E-1
3.525E-1
 3 390
15 C0026987 Myelofibrosis DisGeNET Curated 1.071E-3 2.085E-2
1.335E-1
3.619E-1
 2 90
16 C3884338 Isolated Congenital Heart Block DisGeNET BeFree 1.110E-3 2.085E-2
1.335E-1
3.753E-1
 1 2
17 C0238034 Intraductal papilloma of breast DisGeNET BeFree 1.110E-3 2.085E-2
1.335E-1
3.753E-1
 1 2
18 C0863194 Resectable Hepatocellular Carcinoma DisGeNET BeFree 1.110E-3 2.085E-2
1.335E-1
3.753E-1
 1 2
19 C0009691 Congenital cataract DisGeNET Curated 1.268E-3 2.255E-2
1.444E-1
4.285E-1
 2 98
20 OMIN:604571 BARE LYMPHOCYTE SYNDROME, TYPE I OMIM 1.665E-3 2.559E-2
1.638E-1
5.629E-1
 1 3
21 cv:C1858266 Bare lymphocyte syndrome type 1 Clinical Variations 1.665E-3 2.559E-2
1.638E-1
5.629E-1
 1 3
22 cv:C0040028 Essential thrombocythemia Clinical Variations 1.665E-3 2.559E-2
1.638E-1
5.629E-1
 1 3
23 20090713:International Schizophrenia Consortium Schizophrenia GWAS 2.220E-3 2.616E-2
1.675E-1
7.503E-1
 1 4
24 OMIN:254450 MYELOFIBROSIS OMIM 2.220E-3 2.616E-2
1.675E-1
7.503E-1
 1 4
25 cv:C0001815 Myelofibrosis Clinical Variations 2.220E-3 2.616E-2
1.675E-1
7.503E-1
 1 4
26 C1858680 Familial encephalopathy with neuroserpin inclusion bodies DisGeNET Curated 2.220E-3 2.616E-2
1.675E-1
7.503E-1
 1 4
27 20090207:Zhang Psoriasis GWAS 2.220E-3 2.616E-2
1.675E-1
7.503E-1
 1 4
28 C0451695 Major histocompatibility complex class I deficiency DisGeNET Curated 2.220E-3 2.616E-2
1.675E-1
7.503E-1
 1 4
29 C0040028 Thrombocythemia, Essential DisGeNET Curated 2.528E-3 2.616E-2
1.675E-1
8.545E-1
 2 139
30 C0018939 Hematological Disease DisGeNET Curated 2.564E-3 2.616E-2
1.675E-1
8.666E-1
 2 140
31 C3266123 Serrated polyp DisGeNET BeFree 2.774E-3 2.616E-2
1.675E-1
9.377E-1
 1 5
32 OMIN:187950 THROMBOCYTHEMIA, ESSENTIAL OMIM 2.774E-3 2.616E-2
1.675E-1
9.377E-1
 1 5
33 C0023009 Speech and language disorder DisGeNET BeFree 2.774E-3 2.616E-2
1.675E-1
9.377E-1
 1 5
34 C0342336 Insulin resistance - type A DisGeNET Curated 2.774E-3 2.616E-2
1.675E-1
9.377E-1
 1 5
35 C0457506 Reactive thrombocytosis DisGeNET BeFree 2.774E-3 2.616E-2
1.675E-1
9.377E-1
 1 5
36 C1847835 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) DisGeNET Curated 3.211E-3 2.616E-2
1.675E-1
1.000E0
 2 157
37 C0268113 Familial juvenile gout DisGeNET Curated 3.328E-3 2.616E-2
1.675E-1
1.000E0
 1 6
38 C0036285 Scarlet Fever DisGeNET BeFree 3.328E-3 2.616E-2
1.675E-1
1.000E0
 1 6
39 C0277524 Infectious colitis DisGeNET BeFree 3.328E-3 2.616E-2
1.675E-1
1.000E0
 1 6
40 C0268353 Cutis laxa, x-linked DisGeNET Curated 3.328E-3 2.616E-2
1.675E-1
1.000E0
 1 6
41 C4025187 Increased megakaryocyte count DisGeNET Curated 3.328E-3 2.616E-2
1.675E-1
1.000E0
 1 6
42 C0029427 Synovial osteochondromatosis DisGeNET BeFree 3.328E-3 2.616E-2
1.675E-1
1.000E0
 1 6
43 C0008476 Chondromatosis, Synovial DisGeNET BeFree 3.328E-3 2.616E-2
1.675E-1
1.000E0
 1 6
44 C0001815 Primary Myelofibrosis DisGeNET Curated 3.456E-3 2.655E-2
1.700E-1
1.000E0
 2 163
45 C0042900 Vitiligo DisGeNET Curated 3.839E-3 2.676E-2
1.713E-1
1.000E0
 2 172
46 C0221347 Acrocyanosis DisGeNET Curated 3.882E-3 2.676E-2
1.713E-1
1.000E0
 1 7
47 C0860026 Leishmania mexicana disease DisGeNET BeFree 3.882E-3 2.676E-2
1.713E-1
1.000E0
 1 7
48 C0264757 Rheumatic disease of heart valve DisGeNET BeFree 3.882E-3 2.676E-2
1.713E-1
1.000E0
 1 7
49 20090710:Stefansson Schizophrenia GWAS 3.882E-3 2.676E-2
1.713E-1
1.000E0
 1 7
50 C0019189 Hepatitis, Chronic DisGeNET Curated 4.061E-3 2.676E-2
1.713E-1
1.000E0
 2 177
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