Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc263_10, positive side

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1: GO: Molecular Function [Display Chart] 10 input genes in category / 25 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0050786 RAGE receptor binding 1.057E-14 2.643E-13 1.009E-12 2.643E-13 5 12
2 GO:0044548 S100 protein binding 3.160E-8 3.123E-7 1.192E-6 7.901E-7 3 13
3 GO:0048306 calcium-dependent protein binding 3.748E-8 3.123E-7 1.192E-6 9.369E-7 4 70
4 GO:0035662 Toll-like receptor 4 binding 2.142E-3 1.337E-2
5.102E-2
5.355E-2
 1 4
5 GO:0050544 arachidonic acid binding 3.746E-3 1.337E-2
5.102E-2
9.364E-2
 1 7
6 GO:0050543 icosatetraenoic acid binding 4.280E-3 1.337E-2
5.102E-2
1.070E-1
 1 8
7 GO:1901567 fatty acid derivative binding 4.814E-3 1.337E-2
5.102E-2
1.203E-1
 1 9
8 GO:0050542 icosanoid binding 4.814E-3 1.337E-2
5.102E-2
1.203E-1
 1 9
9 GO:0035325 Toll-like receptor binding 4.814E-3 1.337E-2
5.102E-2
1.203E-1
 1 9
10 GO:0005523 tropomyosin binding 7.479E-3 1.700E-2
6.486E-2
1.870E-1
 1 14
11 GO:0048156 tau protein binding 7.479E-3 1.700E-2
6.486E-2
1.870E-1
 1 14
12 GO:0036041 long-chain fatty acid binding 9.606E-3 2.001E-2
7.637E-2
2.402E-1
 1 18
13 GO:0017134 fibroblast growth factor binding 1.438E-2 2.765E-2
1.055E-1
3.595E-1
 1 27
14 GO:0005504 fatty acid binding 2.491E-2 4.448E-2
1.697E-1
6.227E-1
 1 47
15 GO:0043621 protein self-association 2.961E-2 4.936E-2
1.883E-1
7.404E-1
 1 56
16 GO:0005507 copper ion binding 3.170E-2 4.953E-2
1.890E-1
7.925E-1
 1 60
Show 11 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 280 annotations before applied cutoff / 18623 genes in category

No results to display

3: GO: Cellular Component [Display Chart] 10 input genes in category / 22 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001726 ruffle 7.849E-5 1.727E-3 6.373E-3 1.727E-3 3 169
2 GO:0031252 cell leading edge 9.097E-4 1.001E-2 3.693E-2 2.001E-2 3 389
3 GO:0036457 keratohyalin granule 1.573E-3 1.154E-2 4.258E-2 3.461E-2 1 3
4 GO:0019897 extrinsic component of plasma membrane 2.726E-3 1.499E-2
5.534E-2
5.997E-2
 2 152
5 GO:0019898 extrinsic component of membrane 8.829E-3 3.773E-2
1.392E-1
1.942E-1
 2 278
6 GO:0031528 microvillus membrane 1.097E-2 3.773E-2
1.392E-1
2.412E-1
 1 21
7 GO:0042629 mast cell granule 1.200E-2 3.773E-2
1.392E-1
2.641E-1
 1 23
Show 2 more annotations

4: Human Phenotype [Display Chart] 1 input genes in category / 13 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000976 Eczematoid dermatitis 2.337E-3 3.038E-2
9.661E-2
 3.038E-2 1 11

5: Mouse Phenotype [Display Chart] 4 input genes in category / 45 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003177 allodynia 1.017E-5 4.576E-4 2.011E-3 4.576E-4 2 14
2 MP:0003469 decreased single cell response intensity 7.725E-4 1.159E-2
5.092E-2
 3.476E-2 1 2
3 MP:0003467 abnormal single cell response intensity 7.725E-4 1.159E-2
5.092E-2
 3.476E-2 1 2
4 MP:0001970 abnormal pain threshold 3.400E-3 3.825E-2
1.681E-1
1.530E-1
 2 251
5 MP:0001968 abnormal touch/ nociception 4.989E-3 4.490E-2
1.973E-1
2.245E-1
 2 305

6: Domain [Display Chart] 10 input genes in category / 22 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF01023 S 100 Pfam 5.760E-30 3.942E-29 1.455E-28 1.267E-28 10 27
2 PS00303 S100 CABP PROSITE 5.760E-30 3.942E-29 1.455E-28 1.267E-28 10 27
3 IPR001751 S100/CaBP-9k CS InterPro 8.960E-30 3.942E-29 1.455E-28 1.971E-28 10 28
4 IPR013787 S100 Ca-bd sub InterPro 8.960E-30 3.942E-29 1.455E-28 1.971E-28 10 28
5 SM01394 S 100 SMART 8.960E-30 3.942E-29 1.455E-28 1.971E-28 10 28
6 IPR002048 EF hand dom InterPro 6.982E-20 2.560E-19 9.449E-19 1.536E-18 10 232
7 1.10.238.10 - Gene3D 2.318E-19 7.285E-19 2.689E-18 5.100E-18 10 261
8 IPR011992 EF-hand-dom pair InterPro 6.088E-19 1.674E-18 6.179E-18 1.339E-17 10 287
9 PS00018 EF HAND 1 PROSITE 1.786E-17 4.365E-17 1.611E-16 3.929E-16 9 204
10 PS50222 EF HAND 2 PROSITE 5.575E-17 1.227E-16 4.527E-16 1.227E-15 9 231
11 PF00036 EF-hand 1 Pfam 6.919E-16 1.384E-15 5.108E-15 1.522E-14 8 152
12 IPR018247 EF Hand 1 Ca BS InterPro 6.446E-13 1.182E-12 4.362E-12 1.418E-11 7 175
13 SM00054 EFh SMART 9.751E-9 1.650E-8 6.091E-8 2.145E-7 5 158
14 IPR028477 S100A7 InterPro 2.564E-7 4.030E-7 1.487E-6 5.641E-6 2 2
15 IPR028476 S100-A10 InterPro 5.338E-4 5.592E-4 2.064E-3 1.174E-2 1 1
16 PF03516 Filaggrin Pfam 5.338E-4 5.592E-4 2.064E-3 1.174E-2 1 1
17 IPR028487 S100A13 InterPro 5.338E-4 5.592E-4 2.064E-3 1.174E-2 1 1
18 IPR028481 S100-B InterPro 5.338E-4 5.592E-4 2.064E-3 1.174E-2 1 1
19 IPR028482 S100A11 InterPro 5.338E-4 5.592E-4 2.064E-3 1.174E-2 1 1
20 IPR028475 S100-A9 InterPro 5.338E-4 5.592E-4 2.064E-3 1.174E-2 1 1
21 IPR028494 S100P InterPro 5.338E-4 5.592E-4 2.064E-3 1.174E-2 1 1
22 IPR003303 Filaggrin InterPro 1.067E-3 1.067E-3 3.939E-3 2.348E-2 1 2
Show 17 more annotations

7: Pathway [Display Chart] 10 input genes in category / 37 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5883 Genes encoding secreted soluble factors MSigDB C2 BIOCARTA (v6.0) 2.281E-16 8.440E-15 3.546E-14 8.440E-15 10 344
2 1457778 Metal sequestration by antimicrobial proteins BioSystems: REACTOME 7.454E-9 1.379E-7 5.794E-7 2.758E-7 3 6
3 1457777 Antimicrobial peptides BioSystems: REACTOME 6.701E-5 8.264E-4 3.472E-3 2.479E-3 3 105
4 1457780 Neutrophil degranulation BioSystems: REACTOME 4.183E-4 3.870E-3 1.626E-2 1.548E-2 4 492
5 1474301 IL-17 signaling pathway BioSystems: KEGG 2.389E-3 1.768E-2
7.428E-2
8.840E-2
 2 93
6 1269204 Toll-Like Receptors Cascades BioSystems: REACTOME 6.329E-3 3.903E-2
1.640E-1
2.342E-1
 2 153
7 1269372 Dissolution of Fibrin Clot BioSystems: REACTOME 1.040E-2 4.274E-2
1.796E-1
3.847E-1
 1 13
8 1269258 Advanced glycosylation endproduct receptor signaling BioSystems: REACTOME 1.040E-2 4.274E-2
1.796E-1
3.847E-1
 1 13
9 1269276 DEx/H-box helicases activate type I IFN and inflammatory cytokines production BioSystems: REACTOME 1.040E-2 4.274E-2
1.796E-1
3.847E-1
 1 13
10 1427857 Regulation of TLR by endogenous ligand BioSystems: REACTOME 1.278E-2 4.729E-2
1.987E-1
4.729E-1
 1 16
Show 5 more annotations

8: Pubmed [Display Chart] 10 input genes in category / 2059 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7759097 Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Pubmed 5.159E-27 1.062E-23 8.719E-23 1.062E-23 8 16
2 8701470 The S100 family of EF-hand calcium-binding proteins: functions and pathology. Pubmed 4.500E-20 4.633E-17 3.803E-16 9.266E-17 6 12
3 16938360 An update of the S100 nomenclature. Pubmed 2.437E-19 1.673E-16 1.373E-15 5.018E-16 6 15
4 10395934 Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Pubmed 9.374E-17 4.825E-14 3.960E-13 1.930E-13 5 10
5 8341667 Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. Pubmed 1.718E-16 7.077E-14 5.808E-13 3.538E-13 5 11
6 15336958 S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Pubmed 4.786E-16 1.642E-13 1.348E-12 9.854E-13 5 13
7 19601998 Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. Pubmed 7.561E-15 2.224E-12 1.825E-11 1.557E-11 5 21
8 9920416 Clustered organization of S100 genes in human and mouse. Pubmed 2.983E-13 7.678E-11 6.301E-10 6.142E-10 4 9
9 27068509 Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Pubmed 5.834E-13 1.335E-10 1.095E-9 1.201E-9 6 146
10 15203200 Probing the S100 protein family through genomic and functional analysis. Pubmed 1.171E-12 2.412E-10 1.980E-9 2.412E-9 4 12
11 21663912 Association of increased S100B, S100A6 and S100P in serum levels with acute coronary syndrome and also with the severity of myocardial infarction in cardiac tissue of rat models with ischemia-reperfusion injury. Pubmed 1.292E-11 2.419E-9 1.986E-8 2.661E-8 3 3
12 11258932 S100A7, S100A10, and S100A11 are transglutaminase substrates. Pubmed 5.169E-11 7.602E-9 6.240E-8 1.064E-7 3 4
13 12704215 S100 protein subcellular localization during epidermal differentiation and psoriasis. Pubmed 5.169E-11 7.602E-9 6.240E-8 1.064E-7 3 4
14 10913138 S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. Pubmed 5.169E-11 7.602E-9 6.240E-8 1.064E-7 3 4
15 12526882 Expression of members of the S100 Ca2+-binding protein family in guinea-pig smooth muscle. Pubmed 1.292E-10 1.565E-8 1.284E-7 2.660E-7 3 5
16 12746458 Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. Pubmed 1.292E-10 1.565E-8 1.284E-7 2.660E-7 3 5
17 2149559 Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3. Pubmed 1.292E-10 1.565E-8 1.284E-7 2.660E-7 3 5
18 12042313 CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. Pubmed 2.584E-10 2.800E-8 2.298E-7 5.320E-7 3 6
19 12118070 S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells. Pubmed 2.584E-10 2.800E-8 2.298E-7 5.320E-7 3 6
20 28765046 Identification and characterization of a centrosomal protein, FOR20 as a novel S100A6 target. Pubmed 1.085E-9 1.117E-7 9.166E-7 2.234E-6 3 9
21 15740587 Expression patterns of S100A7 (psoriasin) and S100A9 (calgranulin-B) in keratinocyte differentiation. Pubmed 6.170E-8 5.293E-6 4.344E-5 1.270E-4 2 2
22 21938494 S100-A10, thioredoxin, and S100-A6 as biomarkers of papillary thyroid carcinoma with lymph node metastasis identified by MALDI imaging. Pubmed 6.170E-8 5.293E-6 4.344E-5 1.270E-4 2 2
23 19048101 Colon-derived liver metastasis, colorectal carcinoma, and hepatocellular carcinoma can be discriminated by the Ca(2+)-binding proteins S100A6 and S100A11. Pubmed 6.170E-8 5.293E-6 4.344E-5 1.270E-4 2 2
24 20226301 Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis. Pubmed 6.170E-8 5.293E-6 4.344E-5 1.270E-4 2 2
25 1286667 Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. Pubmed 1.823E-7 1.314E-5 1.078E-4 3.754E-4 3 45
26 10610721 Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. Pubmed 1.851E-7 1.314E-5 1.078E-4 3.811E-4 2 3
27 9925766 Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma. Pubmed 1.851E-7 1.314E-5 1.078E-4 3.811E-4 2 3
28 17726019 S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains. Pubmed 1.851E-7 1.314E-5 1.078E-4 3.811E-4 2 3
29 8985590 Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. Pubmed 1.851E-7 1.314E-5 1.078E-4 3.811E-4 2 3
30 8645219 Isolation of the murine S100 protein MRP14 (14 kDa migration-inhibitory-factor-related protein) from activated spleen cells: characterization of post-translational modifications and zinc binding. Pubmed 3.701E-7 2.241E-5 1.840E-4 7.620E-4 2 4
31 23378728 S100 A and B expression in normal and inflamed human limbus. Pubmed 3.701E-7 2.241E-5 1.840E-4 7.620E-4 2 4
32 12923069 Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family. Pubmed 3.701E-7 2.241E-5 1.840E-4 7.620E-4 2 4
33 18606705 Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. Pubmed 3.701E-7 2.241E-5 1.840E-4 7.620E-4 2 4
34 7511035 Neuro-glial neurotrophic interaction in the S-100 beta retarded mutant mouse (Polydactyly Nagoya). I. Immunocytochemical and neurochemical studies. Pubmed 3.701E-7 2.241E-5 1.840E-4 7.620E-4 2 4
35 15033494 S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells. Pubmed 6.167E-7 3.175E-5 2.606E-4 1.270E-3 2 5
36 12664160 Genomic and phylogenetic analysis of the S100A7 (Psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21. Pubmed 6.167E-7 3.175E-5 2.606E-4 1.270E-3 2 5
37 17625598 S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4. Pubmed 6.167E-7 3.175E-5 2.606E-4 1.270E-3 2 5
38 1940442 Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin. Pubmed 6.167E-7 3.175E-5 2.606E-4 1.270E-3 2 5
39 19297317 Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers. Pubmed 6.167E-7 3.175E-5 2.606E-4 1.270E-3 2 5
40 10399917 RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Pubmed 6.167E-7 3.175E-5 2.606E-4 1.270E-3 2 5
41 18385759 Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation. Pubmed 9.250E-7 4.535E-5 3.722E-4 1.905E-3 2 6
42 18588753 Epithelial genes in chronic rhinosinusitis with and without nasal polyps. Pubmed 9.250E-7 4.535E-5 3.722E-4 1.905E-3 2 6
43 20591429 S100 proteins interact with the N-terminal domain of MDM2. Pubmed 1.295E-6 6.200E-5 5.089E-4 2.666E-3 2 7
44 23344957 Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein). Pubmed 2.219E-6 1.038E-4 8.523E-4 4.569E-3 2 9
45 27707970 A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles. Pubmed 4.067E-6 1.861E-4 1.527E-3 8.373E-3 2 12
46 28675934 Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. Pubmed 5.089E-6 2.278E-4 1.870E-3 1.048E-2 3 135
47 21805676 Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection. Pubmed 8.374E-6 3.668E-4 3.011E-3 1.724E-2 2 17
48 17110338 Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Pubmed 1.440E-5 5.581E-4 4.580E-3 2.964E-2 3 191
49 16799092 Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA). Pubmed 1.556E-5 5.581E-4 4.580E-3 3.205E-2 2 23
50 28344315 Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Pubmed 1.157E-4 5.581E-4 4.580E-3
2.382E-1
 2 62
Show 45 more annotations

9: Interaction [Display Chart] 10 input genes in category / 306 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:S100B S100B interactions 1.074E-8 3.288E-6 2.072E-5 3.288E-6 4 49
2 int:FOPNL FOPNL interactions 1.717E-7 2.203E-5 1.388E-4 5.254E-5 3 21
3 int:SUSD3 SUSD3 interactions 2.285E-7 2.203E-5 1.388E-4 6.992E-5 3 23
4 int:TBC1D22B TBC1D22B interactions 2.879E-7 2.203E-5 1.388E-4 8.811E-5 4 110
5 int:ZIC1 ZIC1 interactions 1.945E-6 1.191E-4 7.503E-4 5.953E-4 3 46
6 int:S100A4 S100A4 interactions 6.381E-6 3.254E-4 2.051E-3 1.952E-3 3 68
7 int:CACYBP CACYBP interactions 1.082E-5 4.730E-4 2.981E-3 3.311E-3 3 81
8 int:SUGT1 SUGT1 interactions 2.640E-5 1.010E-3 6.365E-3 8.080E-3 3 109
9 int:AGER AGER interactions 3.004E-5 1.021E-3 6.436E-3 9.191E-3 2 15
10 int:IGBP1 IGBP1 interactions 4.073E-5 1.246E-3 7.856E-3 1.246E-2 3 126
11 int:S100A2 S100A2 interactions 4.886E-5 1.359E-3 8.566E-3 1.495E-2 2 19
12 int:KIR3DS1 KIR3DS1 interactions 8.556E-5 2.181E-3 1.375E-2 2.618E-2 2 25
13 int:S100A11 S100A11 interactions 9.266E-5 2.181E-3 1.375E-2 2.836E-2 2 26
14 int:S100P S100P interactions 1.000E-4 2.187E-3 1.378E-2 3.061E-2 2 27
15 int:METTL23 METTL23 interactions 1.077E-4 2.197E-3 1.385E-2 3.296E-2 2 28
16 int:S100A1 S100A1 interactions 1.157E-4 2.212E-3 1.394E-2 3.539E-2 2 29
17 int:S100A6 S100A6 interactions 1.791E-4 3.224E-3 2.032E-2
5.480E-2
 2 36
18 int:PLA2G4A PLA2G4A interactions 2.933E-4 4.987E-3 3.143E-2
8.976E-2
 2 46
19 int:SINHCAF SINHCAF interactions 4.508E-4 7.261E-3 4.576E-2
1.380E-1
 2 57
20 int:PAK5 PAK5 interactions 7.388E-4 1.106E-2
6.971E-2
2.261E-1
 2 73
21 int:E2F6 E2F6 interactions 7.591E-4 1.106E-2
6.971E-2
2.323E-1
 2 74
22 int:PI4KA PI4KA interactions 9.999E-4 1.391E-2
8.766E-2
3.060E-1
 2 85
23 int:S100Z S100Z interactions 1.129E-3 1.492E-2
9.402E-2
3.456E-1
 1 2
24 int:AIRE AIRE interactions 1.170E-3 1.492E-2
9.402E-2
3.580E-1
 2 92
25 int:HDLBP HDLBP interactions 1.247E-3 1.526E-2
9.619E-2
3.815E-1
 2 95
26 int:CDK15 CDK15 interactions 1.492E-3 1.756E-2
1.106E-1
4.564E-1
 2 104
27 int:PLA2G4C PLA2G4C interactions 1.694E-3 1.920E-2
1.210E-1
5.183E-1
 1 3
28 int:DDX19B DDX19B interactions 1.851E-3 1.986E-2
1.252E-1
5.664E-1
 2 116
29 int:AHNAK AHNAK interactions 1.882E-3 1.986E-2
1.252E-1
5.760E-1
 2 117
30 int:PPP2R2A PPP2R2A interactions 2.145E-3 2.159E-2
1.361E-1
6.563E-1
 2 125
31 int:ADTRP ADTRP interactions 2.258E-3 2.159E-2
1.361E-1
6.909E-1
 1 4
32 int:CHCHD7 CHCHD7 interactions 2.258E-3 2.159E-2
1.361E-1
6.909E-1
 1 4
33 int:ELMOD3 ELMOD3 interactions 2.822E-3 2.616E-2
1.649E-1
8.634E-1
 1 5
34 int:CD2BP2 CD2BP2 interactions 2.911E-3 2.620E-2
1.651E-1
8.907E-1
 2 146
35 int:ANXA2 ANXA2 interactions 3.110E-3 2.719E-2
1.713E-1
9.515E-1
 2 151
36 int:PCSK6 PCSK6 interactions 3.385E-3 2.726E-2
1.718E-1
1.000E0
 1 6
37 int:MANBAL MANBAL interactions 3.385E-3 2.726E-2
1.718E-1
1.000E0
 1 6
38 int:CT45A5 CT45A5 interactions 3.385E-3 2.726E-2
1.718E-1
1.000E0
 1 6
39 int:LRRC45 LRRC45 interactions 3.948E-3 3.098E-2
1.952E-1
1.000E0
 1 7
40 int:RASGEF1C RASGEF1C interactions 4.511E-3 3.210E-2
2.023E-1
1.000E0
 1 8
41 int:S100A7A S100A7A interactions 4.511E-3 3.210E-2
2.023E-1
1.000E0
 1 8
42 int:MLLT11 MLLT11 interactions 4.511E-3 3.210E-2
2.023E-1
1.000E0
 1 8
43 int:GUCY2D GUCY2D interactions 4.511E-3 3.210E-2
2.023E-1
1.000E0
 1 8
44 int:HEBP1 HEBP1 interactions 5.636E-3 3.832E-2
2.415E-1
1.000E0
 1 10
45 int:TMEM159 TMEM159 interactions 5.636E-3 3.832E-2
2.415E-1
1.000E0
 1 10
46 int:HOXD10 HOXD10 interactions 6.198E-3 3.951E-2
2.490E-1
1.000E0
 1 11
47 int:PDYN PDYN interactions 6.198E-3 3.951E-2
2.490E-1
1.000E0
 1 11
48 int:KCNK3 KCNK3 interactions 6.198E-3 3.951E-2
2.490E-1
1.000E0
 1 11
49 int:KCNIP2 KCNIP2 interactions 6.760E-3 4.051E-2
2.553E-1
1.000E0
 1 12
50 int:IL1A IL1A interactions 6.760E-3 4.051E-2
2.553E-1
1.000E0
 1 12
Show 45 more annotations

10: Cytoband [Display Chart] 10 input genes in category / 4 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1q21 1q21 6.592E-14 2.637E-13 5.494E-13 2.637E-13 6 93
2 1q21.3 1q21.3 5.080E-4 1.016E-3 2.117E-3 2.032E-3 2 118
3 4p16 4p16 4.894E-3 6.526E-3 1.360E-2 1.958E-2 1 17
4 21q22.3 21q22.3 3.883E-2 3.883E-2
8.091E-2
1.553E-1
 1 137

11: Transcription Factor Binding Site [Display Chart] 2 input genes in category / 19 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$ETS2 B V$ETS2 B 5.048E-4 9.591E-3 3.403E-2 9.591E-3 2 220
2 V$TAXCREB 02 V$TAXCREB 02 4.499E-3 4.274E-2
1.516E-1
8.548E-2
 1 22

12: Gene Family [Display Chart] 10 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 459 S100 calcium binding proteins|EF-hand domain containing genenames.org 4.889E-27 1.467E-26 2.689E-26 1.467E-26 9 21
2 863 EF-hand domain containing genenames.org 1.709E-14 2.564E-14 4.701E-14 5.128E-14 8 219
3 1350 S100 calcium binding proteins|S100 fused type protein family genenames.org 3.842E-3 3.842E-3 7.043E-3 1.153E-2 1 7

13: Coexpression [Display Chart] 10 input genes in category / 1381 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20460173-ImmPortAntimicrobials Human Immune Kong10 544genes ImmPort Antimicrobials GeneSigDB 5.261E-15 7.266E-12 5.673E-11 7.266E-12 9 469
2 17823248-Table2 Mouse Breast VanHouten07 49genes GeneSigDB 5.535E-12 3.822E-9 2.984E-8 7.643E-9 5 45
3 M7010 Genes down-regulated in IKZF1 [GeneID=10320] knockout: lymphoid-primed multipotent progenitors versus megakaryo-erythrocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 6.049E-9 2.785E-6 2.174E-5 8.354E-6 5 177
4 17178894-Table1 Human Breast Fan06 104genes GeneSigDB 7.620E-8 2.631E-5 2.054E-4 1.052E-4 4 103
5 M2118 Genes down-regulated in pleura relapse of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.691E-7 4.480E-5 3.498E-4 2.336E-4 3 27
6 16434974-Table1 Human StemCell Enk06 139genes GeneSigDB 1.947E-7 4.480E-5 3.498E-4 2.688E-4 4 130
7 M1484 Genes up-regulated in pancreatic cells from mice with double knockout of E2F1 [GeneID=1869] and E2F2 [GeneID=1870] compared to wild type. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.551E-7 7.006E-5 5.470E-4 4.904E-4 4 151
8 M2925 Genes down-regulated in skin: wildtype (BALB/c) versus IFNAR1 [GeneID=3454] knockout. MSigDB C7: Immunologic Signatures (v6.0) 6.557E-7 9.429E-5 7.363E-4 9.055E-4 4 176
9 M3401 Genes down-regulated in comparison of control microglia cells versus those 1 h after stimulation with IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 1.071E-6 9.429E-5 7.363E-4 1.479E-3 4 199
10 M6209 Genes up-regulated in polymorphonuclear leukocytes (1.5h): control versus infection by A. phagocytophilum. MSigDB C7: Immunologic Signatures (v6.0) 1.071E-6 9.429E-5 7.363E-4 1.479E-3 4 199
11 M4482 Genes down-regulated in comparison of naive B cells versus unstimulated neutrophils. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 9.429E-5 7.363E-4 1.509E-3 4 200
12 M3022 Genes down-regulated in comparison of naive versus effector CD8 T cells at contraction (day 15 after LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 9.429E-5 7.363E-4 1.509E-3 4 200
13 M5832 Genes down-regulated in comparison of naive CD8 T cells versus memory CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 9.429E-5 7.363E-4 1.509E-3 4 200
14 M3017 Genes down-regulated in comparison of naive versus memory CD8 T cells (day 40+ after LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 9.429E-5 7.363E-4 1.509E-3 4 200
15 M5820 Genes down-regulated in comparison of naive CD8 T cells versus effector CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 9.429E-5 7.363E-4 1.509E-3 4 200
16 M3013 Genes down-regulated in comparison of naive versus effector CD8 T cells at the peak expansion phase (day8 after LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 9.429E-5 7.363E-4 1.509E-3 4 200
17 17409405-Table1a Human Breast Huper07 66genes BasalCells GeneSigDB 1.347E-6 1.094E-4 8.539E-4 1.860E-3 3 53
18 M13422 Genes up-regulated in basal mammary epithelial cells compared to the luminal ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.425E-6 1.094E-4 8.539E-4 1.969E-3 3 54
19 M10702 Genes down-regulated in metastases from malignant melanoma compared to the primary tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.009E-6 2.187E-4 1.708E-3 4.156E-3 4 258
20 M1914 Genes up-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.983E-6 3.441E-4 2.687E-3 6.882E-3 4 293
21 M2086 Genes up-regulated in ITNK cells (T-lymphocyte progenitors (DN3 cells) reprogrammed to natural killer (NK) cells by ablation of BCL11B [GeneID=64919] gene), compared to the parental DN3 cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.994E-6 3.942E-4 3.078E-3 8.278E-3 4 307
22 M863 Myb-regulated genes in MCF7 (breast cancer) and lung epithelial cell lines overexpressing MYBL2, MYBL1 or MYB [GeneID=4605;4603;4602]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.889E-6 4.325E-4 3.377E-3 9.514E-3 4 318
23 M11884 Genes up-regulated at the peak of an antigen response of naive CD8+ [GeneID=925;926] T-cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.614E-6 5.772E-4 4.507E-3 1.328E-2 4 346
24 M1617 Genes down-regulated in aorta biopsies from mice treated with rosiglitazone [PubChem=77999]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.096E-5 6.305E-4 4.923E-3 1.513E-2 3 106
25 M1917 Genes up-regulated in neural stem cells (NSC) at both 36 h and 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.159E-5 6.402E-4 4.999E-3 1.601E-2 3 108
26 20421987-TableS4 Human Lung Hou10 518genes GeneSigDB 1.391E-5 7.388E-4 5.769E-3 1.921E-2 4 380
27 19755675-TableS6 Human Leukemia Li09 419genes GeneSigDB 1.875E-5 9.592E-4 7.489E-3 2.590E-2 4 410
28 M19618 Hepatic graft versus host disease (GVHD), day 35: genes up-regulated in allogeneic vs syngeneic bone marrow transplant. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.068E-5 1.020E-3 7.963E-3 2.855E-2 3 131
29 M3903 Genes changed in LSK cells (bone marrow) as a function of a QTL for the size of hematopoietic stem cell (HSC) population: comparison of reciprocal congenic strains D.B. Chr3 (DB), B.D. Chr3 (BD) and the parental strains B6 and D2. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.279E-5 1.085E-3 8.473E-3 3.147E-2 2 17
30 M9107 Genes up-regulated in CD4 T conv: control versus over-expression of GATA1 and FOXP3 [GeneID=2623;50943]. MSigDB C7: Immunologic Signatures (v6.0) 2.364E-5 1.088E-3 8.498E-3 3.265E-2 3 137
31 M3645 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.541E-5 1.132E-3 8.839E-3 3.509E-2 4 443
32 18438415-SuppData Human Breast Finak08 164genes GeneSigDB 2.801E-5 1.209E-3 9.440E-3 3.869E-2 3 145
33 M8912 Genes down-regulated in dendritic cells: unstimulated versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 3.162E-5 1.292E-3 1.009E-2 4.367E-2 3 151
34 20686847-Table2 Human Stomach Li10 22genes GeneSigDB 3.181E-5 1.292E-3 1.009E-2 4.393E-2 2 20
35 M5644 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMC from patients with acute S. aureus infection. MSigDB C7: Immunologic Signatures (v6.0) 4.270E-5 1.653E-3 1.291E-2
5.897E-2
 3 167
36 M6750 Genes down-regulated in nasopharyngeal carcinoma (NPC) positive for LMP1 [GeneID=9260], a latent gene of Epstein-Barr virus (EBV). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.826E-5 1.653E-3 1.291E-2
6.664E-2
 3 174
37 M7008 Genes up-regulated in megakaryo-erythrocyte progenitors versus granulo-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 5.163E-5 1.653E-3 1.291E-2
7.131E-2
 3 178
38 M2943 Genes up-regulated in gamma delta intraepithelial lymphocytes from colon: control versus colitis induced by dextran sulfate sodium (DSS). MSigDB C7: Immunologic Signatures (v6.0) 5.163E-5 1.653E-3 1.291E-2
7.131E-2
 3 178
39 M5002 Cluster G24: genes induced in NHEK (normal keratinocyte) but not in SCC12B2 cells (squamous cell carcinoma) by UV-B radiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.317E-5 1.653E-3 1.291E-2
8.724E-2
 2 28
40 M9032 Down-regulated in MCF7 cells (breast cancer) by TLX1 (HOX11) [GeneID=3195]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.568E-5 1.653E-3 1.291E-2
9.071E-2
 3 193
41 15930339-Table3 Human Bladder Blaveri05 30genes SCCvsTCC GeneSigDB 6.784E-5 1.653E-3 1.291E-2
9.368E-2
 2 29
42 M9530 Genes down-regulated in skin: wildtype versus IL1R1 [GeneID=3554] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.194E-5 1.653E-3 1.291E-2
9.934E-2
 3 199
43 M5836 Genes up-regulated in comparison of effector CD8 T cells versus memory CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 7.194E-5 1.653E-3 1.291E-2
9.934E-2
 3 199
44 16880536-table1 Human StemCell Kasper06 30genes GeneSigDB 7.267E-5 1.653E-3 1.291E-2
1.004E-1
 2 30
45 M8522 Genes up-regulated CD8 T cells: mock transduced versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 1.653E-3 1.291E-2
1.008E-1
 3 200
46 M4945 Genes up-regulated in comparison of monocytes versus plasmacytoid dendritic cells (pDC). MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 1.653E-3 1.291E-2
1.008E-1
 3 200
47 M3039 Genes down-regulated in comparison of naive CD8 T cells versus memory CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 1.653E-3 1.291E-2
1.008E-1
 3 200
48 M8367 Genes down-regulated in T reg from: peripheral blood versus cord blood. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 1.653E-3 1.291E-2
1.008E-1
 3 200
49 M6573 Genes up-regulated in dendritic cells: bone marrow-derived versus follicular. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 1.653E-3 1.291E-2
1.008E-1
 3 200
50 M5676 Genes down-regulated in comparison of TconvThy versus TregThy (see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 1.653E-3 1.291E-2
1.008E-1
 3 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 10 input genes in category / 1802 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T U/Kidney Tumour RCC T U/Kidney Tumour RCC T24 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T U/Kidney Tumour RCC T U/Kidney Tumour RCC T24 Adult, Development, and Cancer types 1.384E-9 2.493E-6 2.013E-5 2.493E-6 3 6
2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Normal-Pelvis Wilms Fetus other Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Normal-Pelvis Wilms Fetus other Adult, Development, and Cancer types 5.062E-9 3.284E-6 2.651E-5 9.121E-6 4 50
3 JC iEC 2500 K4 JC iEC top-relative-expression-ranked 2500 k-means-cluster#4 PCBC 5.467E-9 3.284E-6 2.651E-5 9.851E-6 6 382
4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-G/Kidney Normal-Pelvis Wilms EN-G Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-G/Kidney Normal-Pelvis Wilms EN-G Adult, Development, and Cancer types 4.416E-8 1.669E-5 1.347E-4 7.958E-5 4 85
5 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour Wilms U U/Kidney Tumour Wilms U24 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour Wilms U U/Kidney Tumour Wilms U24 Adult, Development, and Cancer types 4.631E-8 1.669E-5 1.347E-4 8.344E-5 4 86
6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney CD8 T cell/Kidney Normal-Pelvis Wilms CD8 T cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney CD8 T cell/Kidney Normal-Pelvis Wilms CD8 T cell Adult, Development, and Cancer types 5.629E-8 1.691E-5 1.365E-4 1.014E-4 3 18
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour Wilms PT-U/Kidney Tumour Wilms PT24 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour Wilms PT-U/Kidney Tumour Wilms PT24 Adult, Development, and Cancer types 9.987E-8 2.571E-5 2.076E-4 1.800E-4 4 104
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Normal-Cortex Wilms Endothelium/Kidney Normal-Cortex Wilms N7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Normal-Cortex Wilms Endothelium/Kidney Normal-Cortex Wilms N7 Adult, Development, and Cancer types 1.584E-7 3.568E-5 2.881E-4 2.854E-4 3 25
9 10X Human 8K PBMC Myeloid Subtype Myeloid-LST1 CST3 AIF1 A Top 200 Genes 10X Human 8K PBMC Myeloid Subtype Myeloid-LST1 CST3 AIF1 A Top 200 Genes 2.833E-7 4.965E-5 4.009E-4 5.104E-4 5 361
10 10X Human 8K PBMC Myeloid Subtype Myeloid-MNDA, CSTA, RP11-1143G9.4 Top 200 Genes 10X Human 8K PBMC Myeloid Subtype Myeloid-MNDA, CSTA, RP11-1143G9.4 Top 200 Genes 2.872E-7 4.965E-5 4.009E-4 5.175E-4 5 362
11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter F-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter F-U Adult, Development, and Cancer types 5.335E-7 4.965E-5 4.009E-4 9.614E-4 3 37
12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP1-like/Kidney Normal-Medulla post-natal kidney MNP1-like Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP1-like/Kidney Normal-Medulla post-natal kidney MNP1-like Adult, Development, and Cancer types 6.272E-7 4.965E-5 4.009E-4 1.130E-3 3 39
13 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Tumour RCC Nephron epithelium/Kidney Tumour RCC N11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Tumour RCC Nephron epithelium/Kidney Tumour RCC N11 Adult, Development, and Cancer types 7.873E-7 4.965E-5 4.009E-4 1.419E-3 3 42
14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour RCC NK cell/Kidney Tumour RCC NK4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour RCC NK cell/Kidney Tumour RCC NK4 Adult, Development, and Cancer types 8.258E-7 4.965E-5 4.009E-4 1.488E-3 4 176
15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Tumour RCC Th cell/Kidney Tumour RCC IN4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Tumour RCC Th cell/Kidney Tumour RCC IN4 Adult, Development, and Cancer types 8.258E-7 4.965E-5 4.009E-4 1.488E-3 4 176
16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Tumour RCC Renal cell carcinoma/Kidney Tumour RCC T4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Tumour RCC Renal cell carcinoma/Kidney Tumour RCC T4 Adult, Development, and Cancer types 8.258E-7 4.965E-5 4.009E-4 1.488E-3 4 176
17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Tumour RCC Endothelium/Kidney Tumour RCC N4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Tumour RCC Endothelium/Kidney Tumour RCC N4 Adult, Development, and Cancer types 8.258E-7 4.965E-5 4.009E-4 1.488E-3 4 176
18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour RCC PT-U/Kidney Tumour RCC PT4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour RCC PT-U/Kidney Tumour RCC PT4 Adult, Development, and Cancer types 8.447E-7 4.965E-5 4.009E-4 1.522E-3 4 177
19 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Tumour RCC Nephrogenesis/Kidney Tumour RCC F4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Tumour RCC Nephrogenesis/Kidney Tumour RCC F4 Adult, Development, and Cancer types 8.447E-7 4.965E-5 4.009E-4 1.522E-3 4 177
20 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour RCC R U/Kidney Tumour RCC R4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour RCC R U/Kidney Tumour RCC R4 Adult, Development, and Cancer types 8.639E-7 4.965E-5 4.009E-4 1.557E-3 4 178
21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Tumour RCC EN-A/Kidney Tumour RCC EN4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Tumour RCC EN-A/Kidney Tumour RCC EN4 Adult, Development, and Cancer types 8.639E-7 4.965E-5 4.009E-4 1.557E-3 4 178
22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Cortex Wilms NK cell/Kidney Normal-Cortex Wilms NK16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Cortex Wilms NK cell/Kidney Normal-Cortex Wilms NK16 Adult, Development, and Cancer types 9.034E-7 4.965E-5 4.009E-4 1.628E-3 4 180
23 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Proliferating NK cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Proliferating NK cell Adult, Development, and Cancer types 9.034E-7 4.965E-5 4.009E-4 1.628E-3 4 180
24 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP1/Kidney Normal-Pelvis Wilms MNP1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP1/Kidney Normal-Pelvis Wilms MNP1 Adult, Development, and Cancer types 9.650E-7 4.965E-5 4.009E-4 1.739E-3 4 183
25 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter PT-U/Ureter Normal RCC PT-U/Ureter Normal RCC PT8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter PT-U/Ureter Normal RCC PT-U/Ureter Normal RCC PT8 Adult, Development, and Cancer types 1.030E-6 4.965E-5 4.009E-4 1.856E-3 4 186
26 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney F-U/Kidney Tumour Wilms F-U/Kidney Tumour Wilms F14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney F-U/Kidney Tumour Wilms F-U/Kidney Tumour Wilms F14 Adult, Development, and Cancer types 1.052E-6 4.965E-5 4.009E-4 1.896E-3 4 187
27 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T regulatory/Kidney Normal-Pelvis Wilms T regulatory Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T regulatory/Kidney Normal-Pelvis Wilms T regulatory Adult, Development, and Cancer types 1.075E-6 4.965E-5 4.009E-4 1.937E-3 4 188
28 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Cortex Wilms Nephron epithelium/Kidney Normal-Cortex Wilms N16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Cortex Wilms Nephron epithelium/Kidney Normal-Cortex Wilms N16 Adult, Development, and Cancer types 1.075E-6 4.965E-5 4.009E-4 1.937E-3 4 188
29 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter EN-A/Ureter Normal RCC EN-A/Ureter Normal RCC EN7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter EN-A/Ureter Normal RCC EN-A/Ureter Normal RCC EN7 Adult, Development, and Cancer types 1.098E-6 4.965E-5 4.009E-4 1.978E-3 4 189
30 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Plasma cell/Kidney Normal-Pelvis Wilms Plasma cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Plasma cell/Kidney Normal-Pelvis Wilms Plasma cell Adult, Development, and Cancer types 1.121E-6 4.965E-5 4.009E-4 2.020E-3 4 190
31 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell 1/Kidney Normal-Cortex post-natal kidney NK cell 1/Kidney Normal-Cortex post-natal kidney IT13 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell 1/Kidney Normal-Cortex post-natal kidney NK cell 1/Kidney Normal-Cortex post-natal kidney IT13 Adult, Development, and Cancer types 1.133E-6 4.965E-5 4.009E-4 2.041E-3 2 4
32 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Tumour PapRCC EN-B/Kidney Tumour PapRCC EN9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Tumour PapRCC EN-B/Kidney Tumour PapRCC EN9 Adult, Development, and Cancer types 1.145E-6 4.965E-5 4.009E-4 2.063E-3 4 191
33 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Overall Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Overall Top 200 Genes 1.145E-6 4.965E-5 4.009E-4 2.063E-3 4 191
34 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-E/Kidney Normal-Pelvis Wilms EN-E/Kidney Normal-Pelvis Wilms EN20 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-E/Kidney Normal-Pelvis Wilms EN-E/Kidney Normal-Pelvis Wilms EN20 Adult, Development, and Cancer types 1.145E-6 4.965E-5 4.009E-4 2.063E-3 4 191
35 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Mesangium (MG) Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Mesangium (MG) Fetal, Development 1.145E-6 4.965E-5 4.009E-4 2.063E-3 4 191
36 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour Wilms PT-U/Kidney Tumour Wilms PT14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour Wilms PT-U/Kidney Tumour Wilms PT14 Adult, Development, and Cancer types 1.193E-6 4.965E-5 4.009E-4 2.150E-3 4 193
37 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour VHL RCC NK cell/Kidney Tumour VHL RCC NK4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour VHL RCC NK cell/Kidney Tumour VHL RCC NK4 Adult, Development, and Cancer types 1.193E-6 4.965E-5 4.009E-4 2.150E-3 4 193
38 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour Wilms U U/Kidney Tumour Wilms U14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour Wilms U U/Kidney Tumour Wilms U14 Adult, Development, and Cancer types 1.193E-6 4.965E-5 4.009E-4 2.150E-3 4 193
39 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/early fetal/IMM m Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/early fetal/IMM m Fetal, Development 1.193E-6 4.965E-5 4.009E-4 2.150E-3 4 193
40 10X Human 8K PBMC Dendritic cells (S100A9, S100A8, LYZ) Top 200 10X Human 8K PBMC Dendritic cells (S100A9, S100A8, LYZ) Top 200 1.218E-6 4.965E-5 4.009E-4 2.195E-3 4 194
41 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex post-natal kidney R U/Kidney Normal-Cortex post-natal kidney R11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex post-natal kidney R U/Kidney Normal-Cortex post-natal kidney R11 Adult, Development, and Cancer types 1.218E-6 4.965E-5 4.009E-4 2.195E-3 4 194
42 10X Human 8K PBMC Dendritic cells (S100A9, S100A8, LYZ) Overall Top 200 Genes 10X Human 8K PBMC Dendritic cells (S100A9, S100A8, LYZ) Overall Top 200 Genes 1.218E-6 4.965E-5 4.009E-4 2.195E-3 4 194
43 10X Human 8K PBMC Myeloid Overall Top 200 Genes 10X Human 8K PBMC Myeloid Overall Top 200 Genes 1.243E-6 4.965E-5 4.009E-4 2.241E-3 4 195
44 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Normal-Cortex Wilms Ureter epithelium/Kidney Normal-Cortex Wilms N19 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Normal-Cortex Wilms Ureter epithelium/Kidney Normal-Cortex Wilms N19 Adult, Development, and Cancer types 1.243E-6 4.965E-5 4.009E-4 2.241E-3 4 195
45 10X Human 8K PBMC Dendritic cells Overall Top 200 Genes 10X Human 8K PBMC Dendritic cells Overall Top 200 Genes 1.269E-6 4.965E-5 4.009E-4 2.287E-3 4 196
46 10X Human 8K PBMC Dendritic cells Top 200 10X Human 8K PBMC Dendritic cells Top 200 1.269E-6 4.965E-5 4.009E-4 2.287E-3 4 196
47 10X Human 8K PBMC Dendritic cells (FCER1A, HLA-DPA1, HLA-DRB5) Overall Top 200 Genes 10X Human 8K PBMC Dendritic cells (FCER1A, HLA-DPA1, HLA-DRB5) Overall Top 200 Genes 1.295E-6 4.965E-5 4.009E-4 2.334E-3 4 197
48 Immune cells (IMM)/Immune cells (IMM) k Immune cells (IMM)/Immune cells (IMM) k 1.348E-6 5.061E-5 4.087E-4 2.430E-3 4 199
49 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal VHL RCC Nephrogenesis/Kidney Normal VHL RCC F7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal VHL RCC Nephrogenesis/Kidney Normal VHL RCC F7 Adult, Development, and Cancer types 1.512E-6 5.449E-5 4.400E-4 2.725E-3 3 52
50 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney Tumour PapRCC EN-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney Tumour PapRCC EN-U Adult, Development, and Cancer types 1.512E-6 5.449E-5 4.400E-4 2.725E-3 3 52
Show 45 more annotations

15: Computational [Display Chart] 8 input genes in category / 51 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M4515 MODULE 324 Metal / Ca ion binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.325E-10 6.756E-9 3.053E-8 6.756E-9 6 133
2 M7639 MODULE 411 Genes in the cancer module 411. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.703E-3 3.189E-2
1.441E-1
8.685E-2
 2 80
3 M5912 MODULE 341 Genes in the cancer module 341. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.876E-3 3.189E-2
1.441E-1
9.566E-2
 2 84
4 M15336 MODULE 6 Trachea genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.387E-3 3.897E-2
1.761E-1
1.727E-1
 3 416
5 M7383 MODULE 5 Lung genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.821E-3 3.897E-2
1.761E-1
1.949E-1
 3 434
6 M16071 MODULE 38 Placenta genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.618E-3 3.925E-2
1.774E-1
2.355E-1
 3 464
7 M10197 MODULE 92 Secreted signaling molecules. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.780E-3 4.211E-2
1.903E-1
2.948E-1
 2 149
Show 2 more annotations

16: MicroRNA [Display Chart] 10 input genes in category / 64 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-590-5p:PITA hsa-miR-590-5p:PITA TOP PITA 5.741E-4 1.865E-2
8.848E-2
 3.674E-2 2 261
2 hsa-miR-21:PITA hsa-miR-21:PITA TOP PITA 5.828E-4 1.865E-2
8.848E-2
 3.730E-2 2 263
3 hsa-miR-1204:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.522E-3 3.246E-2
1.540E-1
9.739E-2
 1 11
4 hsa-miR-132-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.041E-3 4.244E-2
2.013E-1
1.946E-1
 1 22
5 hsa-miR-556-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.450E-3 4.244E-2
2.013E-1
4.768E-1
 1 54
6 hsa-miR-5004-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.450E-3 4.244E-2
2.013E-1
4.768E-1
 1 54
7 hsa-miR-6797-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.000E-3 4.244E-2
2.013E-1
5.120E-1
 1 58
8 hsa-miR-6076:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.138E-3 4.244E-2
2.013E-1
5.208E-1
 1 59
9 hsa-miR-4679:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.511E-3 4.244E-2
2.013E-1
6.087E-1
 1 69
10 hsa-miR-876-3p:Functional MTI Functional MTI miRTarbase 9.648E-3 4.244E-2
2.013E-1
6.175E-1
 1 70
11 hsa-miR-876-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.923E-3 4.244E-2
2.013E-1
6.351E-1
 1 72
12 hsa-miR-3167:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.006E-2 4.244E-2
2.013E-1
6.438E-1
 1 73
13 hsa-miR-296-5p:Functional MTI Functional MTI miRTarbase 1.020E-2 4.244E-2
2.013E-1
6.526E-1
 1 74
14 hsa-miR-648:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.020E-2 4.244E-2
2.013E-1
6.526E-1
 1 74
15 hsa-miR-1290:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.033E-2 4.244E-2
2.013E-1
6.614E-1
 1 75
16 hsa-miR-6516-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.170E-2 4.244E-2
2.013E-1
7.491E-1
 1 85
17 hsa-miR-3934-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.280E-2 4.244E-2
2.013E-1
8.192E-1
 1 93
18 hsa-miR-3591-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.348E-2 4.244E-2
2.013E-1
8.630E-1
 1 98
19 AGGAAGC,MIR-516-3P:MSigDB AGGAAGC,MIR-516-3P:MSigDB MSigDB 1.458E-2 4.244E-2
2.013E-1
9.330E-1
 1 106
20 hsa-miR-921:PITA hsa-miR-921:PITA TOP PITA 1.512E-2 4.244E-2
2.013E-1
9.679E-1
 1 110
21 hsa-miR-4307:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.567E-2 4.244E-2
2.013E-1
1.000E0
 1 114
22 hsa-miR-130a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.799E-2 4.244E-2
2.013E-1
1.000E0
 1 131
23 hsa-miR-23c:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.812E-2 4.244E-2
2.013E-1
1.000E0
 1 132
24 hsa-miR-1322:PITA hsa-miR-1322:PITA TOP PITA 1.853E-2 4.244E-2
2.013E-1
1.000E0
 1 135
25 hsa-miR-7150:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.867E-2 4.244E-2
2.013E-1
1.000E0
 1 136
26 hsa-miR-216b-5p:Functional MTI Functional MTI miRTarbase 1.880E-2 4.244E-2
2.013E-1
1.000E0
 1 137
27 hsa-miR-525-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.894E-2 4.244E-2
2.013E-1
1.000E0
 1 138
28 hsa-miR-520a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.935E-2 4.244E-2
2.013E-1
1.000E0
 1 141
29 hsa-miR-3180-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.962E-2 4.244E-2
2.013E-1
1.000E0
 1 143
30 hsa-miR-141-3p:Functional MTI Functional MTI miRTarbase 1.989E-2 4.244E-2
2.013E-1
1.000E0
 1 145
31 hsa-miR-7854-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.098E-2 4.331E-2
2.055E-1
1.000E0
 1 153
32 hsa-miR-4736:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.342E-2 4.621E-2
2.192E-1
1.000E0
 1 171
33 hsa-miR-3665:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.383E-2 4.621E-2
2.192E-1
1.000E0
 1 174
Show 28 more annotations

17: Drug [Display Chart] 10 input genes in category / 1259 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000002161 amlexanox Stitch 2.347E-18 2.955E-15 2.280E-14 2.955E-15 7 38
2 ctd:C045621 miglitol CTD 3.885E-12 2.445E-9 1.887E-8 4.891E-9 4 10
3 CID000000011 1,2-dichloroethane Stitch 3.421E-10 1.436E-7 1.108E-6 4.307E-7 5 99
4 CID000000838 L-adrenaline Stitch 1.054E-8 3.316E-6 2.558E-5 1.326E-5 6 446
5 DB00768 Olopatadine Drug Bank 1.724E-6 4.341E-4 3.349E-3 2.170E-3 2 5
6 CID000065254 AC1L22WP Stitch 2.725E-6 5.719E-4 4.413E-3 3.431E-3 3 66
7 CID000024524 Fluor Stitch 4.013E-6 7.218E-4 5.570E-3 5.053E-3 3 75
8 ctd:C002202 4-oxoretinoic acid CTD 1.454E-5 2.288E-3 1.766E-2 1.831E-2 3 115
9 CID000028127 PRODAN Stitch 1.806E-5 2.521E-3 1.945E-2 2.274E-2 2 15
10 CID000004871 pomiferin Stitch 2.063E-5 2.521E-3 1.945E-2 2.598E-2 2 16
11 CID000020382 tetradotoxin Stitch 2.335E-5 2.521E-3 1.945E-2 2.939E-2 4 428
12 ctd:C043211 carvedilol CTD 2.403E-5 2.521E-3 1.945E-2 3.026E-2 3 136
13 ctd:C025340 manganese chloride CTD 3.045E-5 2.949E-3 2.275E-2 3.833E-2 4 458
14 ctd:C009007 potassium persulfate CTD 3.967E-5 3.567E-3 2.752E-2 4.994E-2 2 22
15 ctd:C423844 BL 11282 CTD 4.737E-5 3.812E-3 2.942E-2
5.964E-2
 2 24
16 CID000432945 NSC319518 Stitch 5.148E-5 3.812E-3 2.942E-2
6.481E-2
 2 25
17 CID006483663 CA-11 Stitch 5.148E-5 3.812E-3 2.942E-2
6.481E-2
 2 25
18 CID004635108 AC1NE1MQ Stitch 9.606E-5 6.719E-3
5.184E-2
1.209E-1
 2 34
19 ctd:D006108 Graphite CTD 1.203E-4 7.969E-3
6.149E-2
1.514E-1
 2 38
20 CID000027686 cromoglicate Stitch 1.402E-4 8.824E-3
6.809E-2
1.765E-1
 2 41
21 ctd:C044387 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine CTD 2.299E-4 1.378E-2
1.063E-1
2.894E-1
 3 291
22 ctd:C103303 alitretinoin CTD 2.589E-4 1.426E-2
1.100E-1
3.259E-1
 3 303
23 CID000104901 acrylodan Stitch 2.623E-4 1.426E-2
1.100E-1
3.303E-1
 2 56
24 ctd:C030299 phenylhydrazine CTD 2.718E-4 1.426E-2
1.100E-1
3.422E-1
 2 57
25 ctd:D010615 Phenacetin CTD 3.757E-4 1.575E-2
1.215E-1
4.730E-1
 2 67
26 ctd:C013099 mancozeb CTD 4.101E-4 1.575E-2
1.215E-1
5.163E-1
 2 70
27 CID000099338 2-methoxy-1,3-butadiene Stitch 4.378E-4 1.575E-2
1.215E-1
5.512E-1
 1 1
28 CID000011226 phenoperidine Stitch 4.378E-4 1.575E-2
1.215E-1
5.512E-1
 1 1
29 DB06941 (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide Drug Bank 4.378E-4 1.575E-2
1.215E-1
5.512E-1
 1 1
30 CID000413105 pHS23 Stitch 4.378E-4 1.575E-2
1.215E-1
5.512E-1
 1 1
31 CID000019169 2,3-dimethoxy-1,3-butadiene Stitch 4.378E-4 1.575E-2
1.215E-1
5.512E-1
 1 1
32 CID003036079 UK-88,947 Stitch 4.378E-4 1.575E-2
1.215E-1
5.512E-1
 1 1
33 CID000085695 1-deoxy-1-nitro-D-mannitol Stitch 4.378E-4 1.575E-2
1.215E-1
5.512E-1
 1 1
34 ctd:C507130 2-(8-quinolinoxy)propionic acid CTD 4.378E-4 1.575E-2
1.215E-1
5.512E-1
 1 1
35 DB07004 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide Drug Bank 4.378E-4 1.575E-2
1.215E-1
5.512E-1
 1 1
36 ctd:C059765 amphotericin B, deoxycholate drug combination CTD 5.422E-4 1.896E-2
1.463E-1
6.826E-1
 3 390
37 ctd:D002122 Calcium Chloride CTD 5.623E-4 1.913E-2
1.476E-1
7.080E-1
 2 82
38 CID000003673 pimeprofen Stitch 5.900E-4 1.955E-2
1.508E-1
7.428E-1
 2 84
39 ctd:D010476 Perfume CTD 6.620E-4 2.137E-2
1.649E-1
8.334E-1
 2 89
40 ctd:C095105 bexarotene CTD 7.805E-4 2.296E-2
1.772E-1
9.827E-1
 3 442
41 CID006327536 methylidenesilicon Stitch 8.346E-4 2.296E-2
1.772E-1
1.000E0
 2 100
42 ctd:C575690 mono-isobutyl phthalate CTD 8.754E-4 2.296E-2
1.772E-1
1.000E0
 1 2
43 ctd:C480180 beta-1,3-D-glucan CTD 8.754E-4 2.296E-2
1.772E-1
1.000E0
 1 2
44 CID000190915 2-thiokojibiose Stitch 8.754E-4 2.296E-2
1.772E-1
1.000E0
 1 2
45 CID000072431 AC1L2I2D Stitch 8.754E-4 2.296E-2
1.772E-1
1.000E0
 1 2
46 DB01003 Cromoglicic acid Drug Bank 8.754E-4 2.296E-2
1.772E-1
1.000E0
 1 2
47 ctd:C043077 ipsapirone CTD 8.754E-4 2.296E-2
1.772E-1
1.000E0
 1 2
48 ctd:C051450 2-ethyl-5-carboxypentyl phthalate CTD 8.754E-4 2.296E-2
1.772E-1
1.000E0
 1 2
49 CID000002144 EG 2 Stitch 9.370E-4 2.408E-2
1.858E-1
1.000E0
 2 106
50 ctd:C010974 glyphosate CTD 9.854E-4 2.481E-2
1.915E-1
1.000E0
 3 479
Show 45 more annotations

18: Disease [Display Chart] 10 input genes in category / 399 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1832097 EPIDERMAL DIFFERENTIATION COMPLEX DisGeNET BeFree 9.203E-15 3.672E-12 2.412E-11 3.672E-12 6 33
2 C0751895 Vasospasm, Intracranial DisGeNET Curated 3.424E-6 6.831E-4 4.486E-3 1.366E-3 2 5
3 C0011615 Dermatitis, Atopic DisGeNET Curated 7.586E-5 6.460E-3 4.242E-2 3.027E-2 4 411
4 C0011334 Dental caries DisGeNET Curated 8.208E-5 6.460E-3 4.242E-2 3.275E-2 3 146
5 C3875321 Inflammatory dermatosis DisGeNET BeFree 8.719E-5 6.460E-3 4.242E-2 3.479E-2 3 149
6 C0013595 Eczema DisGeNET Curated 9.714E-5 6.460E-3 4.242E-2 3.876E-2 4 438
7 C0011603 Dermatitis DisGeNET Curated 1.358E-4 7.317E-3 4.806E-2
5.418E-2
 3 173
8 C0238463 Papillary thyroid carcinoma DisGeNET Curated 1.524E-4 7.317E-3 4.806E-2
6.080E-2
 4 492
9 C1402294 Primary Lesion DisGeNET BeFree 1.791E-4 7.317E-3 4.806E-2
7.147E-2
 2 33
10 C0023652 Lichen Sclerosus et Atrophicus DisGeNET BeFree 1.903E-4 7.317E-3 4.806E-2
7.592E-2
 2 34
11 C0206728 Plexiform Neurofibroma DisGeNET Curated 2.017E-4 7.317E-3 4.806E-2
8.049E-2
 2 35
12 C0221228 Comedone DisGeNET BeFree 2.257E-4 7.503E-3 4.928E-2
9.004E-2
 2 37
13 C0280220 stage, ovarian epithelial cancer DisGeNET BeFree 2.509E-4 7.701E-3
5.057E-2
1.001E-1
 2 39
14 C1336527 Carcinoma of urinary bladder, superficial DisGeNET BeFree 2.912E-4 7.943E-3
5.216E-2
1.162E-1
 2 42
15 C0042214 Vaccinia DisGeNET BeFree 2.988E-4 7.943E-3
5.216E-2
1.192E-1
 3 226
16 C2936349 Plaque, Amyloid DisGeNET Curated 3.351E-4 7.943E-3
5.216E-2
1.337E-1
 3 235
17 C0007124 Noninfiltrating Intraductal Carcinoma DisGeNET Curated 5.597E-4 7.943E-3
5.216E-2
2.233E-1
 3 280
18 C0342759 Primary lactose intolerance DisGeNET BeFree 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
19 C1304136 Onset of psoriasis in childhood (1-10 years) DisGeNET BeFree 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
20 C0018944 Hematoma DisGeNET Curated 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
21 OMIN:146700 ICHTHYOSIS VULGARIS OMIM 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
22 C1276070 Infantile atopic dermatitis DisGeNET BeFree 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
23 C1304345 Occupational irritant contact dermatitis DisGeNET BeFree 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
24 cv:C1853965 Dermatitis, atopic, 2 Clinical Variations 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
25 C0262974 Subacute dermatitis DisGeNET BeFree 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
26 OMIN:605803 DERMATITIS, ATOPIC, 2; ATOD2 OMIM 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
27 C2316159 Oral allergy syndrome DisGeNET BeFree 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
28 C1266100 Carcinoma showing thymus-like element DisGeNET BeFree 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
29 C1853965 Dermatitis, Atopic, 2 DisGeNET Curated 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
30 C1276092 Chronic hand eczema DisGeNET BeFree 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
31 cv:C0079584 Ichthyosis vulgaris Clinical Variations 6.171E-4 7.943E-3
5.216E-2
2.462E-1
 1 1
32 C0333463 Senile Plaques DisGeNET BeFree 7.601E-4 9.477E-3
6.224E-2
3.033E-1
 3 311
33 C0341106 Eosinophilic esophagitis DisGeNET Curated 8.326E-4 1.007E-2
6.611E-2
3.322E-1
 2 71
34 C0263224 Flexural atopic dermatitis DisGeNET BeFree 1.234E-3 1.231E-2
8.083E-2
4.923E-1
 1 2
35 C0475811 Disorder of keratinization DisGeNET BeFree 1.234E-3 1.231E-2
8.083E-2
4.923E-1
 1 2
36 C0474892 Inherited disorder of keratinization DisGeNET BeFree 1.234E-3 1.231E-2
8.083E-2
4.923E-1
 1 2
37 C1275684 Meibomian gland dysfunction DisGeNET BeFree 1.234E-3 1.231E-2
8.083E-2
4.923E-1
 1 2
38 C1860229 Hyperzincemia and Hypercalprotectinemia DisGeNET BeFree 1.234E-3 1.231E-2
8.083E-2
4.923E-1
 1 2
39 C0344183 Exercise anaphylaxis DisGeNET BeFree 1.234E-3 1.231E-2
8.083E-2
4.923E-1
 1 2
40 C0236964 Attention Deficit and Disruptive Behavior Disorders DisGeNET Curated 1.234E-3 1.231E-2
8.083E-2
4.923E-1
 1 2
41 C0025286 Meningioma DisGeNET Curated 1.678E-3 1.448E-2
9.507E-2
6.696E-1
 3 409
42 C1704272 Benign Prostatic Hyperplasia DisGeNET BeFree 1.738E-3 1.448E-2
9.507E-2
6.934E-1
 3 414
43 C0334474 Spindle cell lipoma DisGeNET BeFree 1.850E-3 1.448E-2
9.507E-2
7.383E-1
 1 3
44 C1275114 Epidermolysis Bullosa Pruriginosa DisGeNET Curated 1.850E-3 1.448E-2
9.507E-2
7.383E-1
 1 3
45 C1882972 Salivary Gland Low Grade Cribriform Cystadenocarcinoma DisGeNET BeFree 1.850E-3 1.448E-2
9.507E-2
7.383E-1
 1 3
46 C0278984 Non-small cell lung cancer stage IIIB DisGeNET BeFree 1.850E-3 1.448E-2
9.507E-2
7.383E-1
 1 3
47 C0344462 Chronic lymphoproliferative disease NOS DisGeNET BeFree 1.850E-3 1.448E-2
9.507E-2
7.383E-1
 1 3
48 C1266175 Parachordoma DisGeNET BeFree 1.850E-3 1.448E-2
9.507E-2
7.383E-1
 1 3
49 C1864445 Histiocytosis with joint contractures and sensorineural deafness DisGeNET Curated 1.850E-3 1.448E-2
9.507E-2
7.383E-1
 1 3
50 C0678306 alcohol sensitivity DisGeNET Curated 1.850E-3 1.448E-2
9.507E-2
7.383E-1
 1 3
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