Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc268_19, positive side

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1: GO: Molecular Function [Display Chart] 18 input genes in category / 90 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005372 water transmembrane transporter activity 1.306E-18 1.175E-16 5.973E-16 1.175E-16 7 15
2 GO:0015168 glycerol transmembrane transporter activity 2.917E-16 8.752E-15 4.448E-14 2.626E-14 6 12
3 GO:0015254 glycerol channel activity 2.917E-16 8.752E-15 4.448E-14 2.626E-14 6 12
4 GO:0015250 water channel activity 9.471E-16 2.131E-14 1.083E-13 8.524E-14 6 14
5 GO:0015166 polyol transmembrane transporter activity 2.523E-15 4.541E-14 2.308E-13 2.270E-13 6 16
6 GO:0015665 alcohol transmembrane transporter activity 7.213E-14 1.082E-12 5.499E-12 6.492E-12 6 26
7 GO:0015144 carbohydrate transmembrane transporter activity 2.525E-12 3.247E-11 1.650E-10 2.273E-10 6 45
8 GO:1901618 organic hydroxy compound transmembrane transporter activity 1.888E-11 2.124E-10 1.080E-9 1.699E-9 6 62
9 GO:0022838 substrate-specific channel activity 3.078E-9 3.078E-8 1.564E-7 2.770E-7 8 438
10 GO:0015267 channel activity 5.351E-9 4.451E-8 2.262E-7 4.816E-7 8 470
11 GO:0022803 passive transmembrane transporter activity 5.441E-9 4.451E-8 2.262E-7 4.897E-7 8 471
12 GO:0015204 urea transmembrane transporter activity 2.631E-8 1.821E-7 9.258E-7 2.368E-6 3 7
13 GO:0005000 vasopressin receptor activity 2.631E-8 1.821E-7 9.258E-7 2.368E-6 3 7
14 GO:0017046 peptide hormone binding 8.807E-8 5.661E-7 2.877E-6 7.926E-6 4 45
15 GO:0008528 G protein-coupled peptide receptor activity 1.306E-7 7.836E-7 3.983E-6 1.175E-5 5 132
16 GO:0001653 peptide receptor activity 1.461E-7 8.219E-7 4.178E-6 1.315E-5 5 135
17 GO:0042277 peptide binding 1.654E-7 8.758E-7 4.451E-6 1.489E-5 6 278
18 GO:0033218 amide binding 3.083E-7 1.542E-6 7.835E-6 2.775E-5 6 309
19 GO:0042887 amide transmembrane transporter activity 8.503E-7 3.954E-6 2.010E-5 7.652E-5 3 20
20 GO:0031894 V1A vasopressin receptor binding 8.788E-7 3.954E-6 2.010E-5 7.909E-5 2 2
21 GO:0042562 hormone binding 1.062E-6 4.550E-6 2.312E-5 9.555E-5 4 83
22 GO:0031893 vasopressin receptor binding 2.635E-6 1.078E-5 5.478E-5 2.371E-4 2 3
23 GO:0015265 urea channel activity 8.773E-6 3.433E-5 1.745E-4 7.895E-4 2 5
24 GO:0015112 nitrate transmembrane transporter activity 9.646E-4 3.100E-3 1.576E-2
8.681E-2
 1 1
25 GO:0031895 V1B vasopressin receptor binding 9.646E-4 3.100E-3 1.576E-2
8.681E-2
 1 1
26 GO:0030184 nitric oxide transmembrane transporter activity 9.646E-4 3.100E-3 1.576E-2
8.681E-2
 1 1
27 GO:0001596 angiotensin type I receptor activity 9.646E-4 3.100E-3 1.576E-2
8.681E-2
 1 1
28 GO:0004990 oxytocin receptor activity 9.646E-4 3.100E-3 1.576E-2
8.681E-2
 1 1
29 GO:0005080 protein kinase C binding 1.606E-3 4.983E-3 2.533E-2
1.445E-1
 2 62
30 GO:0005185 neurohypophyseal hormone activity 1.928E-3 5.423E-3 2.756E-2
1.735E-1
 1 2
31 GO:0036505 prosaposin receptor activity 1.928E-3 5.423E-3 2.756E-2
1.735E-1
 1 2
32 GO:0035379 carbon dioxide transmembrane transporter activity 1.928E-3 5.423E-3 2.756E-2
1.735E-1
 1 2
33 GO:0001664 G protein-coupled receptor binding 2.215E-3 6.042E-3 3.071E-2
1.994E-1
 3 276
34 GO:0031711 bradykinin receptor binding 2.891E-3 7.653E-3 3.890E-2
2.602E-1
 1 3
35 GO:0004945 angiotensin type II receptor activity 4.814E-3 1.238E-2
6.292E-2
4.333E-1
 1 5
36 GO:0008238 exopeptidase activity 5.219E-3 1.305E-2
6.632E-2
4.697E-1
 2 113
37 GO:0001595 angiotensin receptor activity 5.774E-3 1.405E-2
7.139E-2
5.197E-1
 1 6
38 GO:0005179 hormone activity 6.251E-3 1.480E-2
7.524E-2
5.626E-1
 2 124
39 GO:0005223 intracellular cGMP-activated cation channel activity 6.734E-3 1.554E-2
7.898E-2
6.060E-1
 1 7
40 GO:0031748 D1 dopamine receptor binding 1.056E-2 2.376E-2
1.208E-1
9.506E-1
 1 11
41 GO:0043855 cyclic nucleotide-gated ion channel activity 1.247E-2 2.672E-2
1.358E-1
1.000E0
 1 13
42 GO:0005221 intracellular cyclic nucleotide activated cation channel activity 1.247E-2 2.672E-2
1.358E-1
1.000E0
 1 13
43 GO:0005243 gap junction channel activity 1.628E-2 3.407E-2
1.732E-1
1.000E0
 1 17
44 GO:0070008 serine-type exopeptidase activity 1.818E-2 3.718E-2
1.890E-1
1.000E0
 1 19
45 GO:0050780 dopamine receptor binding 2.102E-2 4.204E-2
2.137E-1
1.000E0
 1 22
46 GO:0005212 structural constituent of eye lens 2.196E-2 4.297E-2
2.184E-1
1.000E0
 1 23
47 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2.385E-2 4.472E-2
2.273E-1
1.000E0
 1 25
48 GO:0022829 wide pore channel activity 2.385E-2 4.472E-2
2.273E-1
1.000E0
 1 25
49 GO:0004181 metallocarboxypeptidase activity 2.574E-2 4.727E-2
2.403E-1
1.000E0
 1 27
50 GO:0008519 ammonium transmembrane transporter activity 2.762E-2 4.874E-2
2.477E-1
1.000E0
 1 29
Show 45 more annotations

2: GO: Biological Process [Display Chart] 18 input genes in category / 694 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006833 water transport 5.946E-20 4.126E-17 2.938E-16 4.126E-17 8 23
2 GO:0042044 fluid transport 7.074E-19 2.455E-16 1.748E-15 4.909E-16 8 30
3 GO:0015793 glycerol transport 5.481E-16 1.268E-13 9.029E-13 3.804E-13 6 13
4 GO:0009992 cellular water homeostasis 1.597E-15 2.771E-13 1.973E-12 1.108E-12 6 15
5 GO:0015791 polyol transport 8.638E-15 1.199E-12 8.537E-12 5.995E-12 6 19
6 GO:0006884 cell volume homeostasis 2.329E-13 2.693E-11 1.918E-10 1.616E-10 6 31
7 GO:0030104 water homeostasis 5.772E-13 5.485E-11 3.905E-10 4.006E-10 7 79
8 GO:0007588 excretion 6.322E-13 5.485E-11 3.905E-10 4.388E-10 7 80
9 GO:0019755 one-carbon compound transport 2.822E-12 2.176E-10 1.549E-9 1.958E-9 5 17
10 GO:0015850 organic hydroxy compound transport 5.344E-11 3.709E-9 2.641E-8 3.709E-8 8 262
11 GO:0003014 renal system process 1.408E-9 8.884E-8 6.326E-7 9.773E-7 6 125
12 GO:0001992 regulation of systemic arterial blood pressure by vasopressin 7.572E-9 4.379E-7 3.118E-6 5.255E-6 3 5
13 GO:0019229 regulation of vasoconstriction 1.126E-8 6.009E-7 4.279E-6 7.812E-6 5 81
14 GO:0008361 regulation of cell size 2.303E-8 1.142E-6 8.129E-6 1.598E-5 6 199
15 GO:0071918 urea transmembrane transport 2.647E-8 1.225E-6 8.721E-6 1.837E-5 3 7
16 GO:0008643 carbohydrate transport 3.085E-8 1.318E-6 9.382E-6 2.141E-5 6 209
17 GO:0003091 renal water homeostasis 3.529E-8 1.318E-6 9.382E-6 2.449E-5 4 36
18 GO:0042310 vasoconstriction 3.615E-8 1.318E-6 9.382E-6 2.509E-5 5 102
19 GO:0050886 endocrine process 3.797E-8 1.318E-6 9.382E-6 2.635E-5 5 103
20 GO:0003073 regulation of systemic arterial blood pressure 3.797E-8 1.318E-6 9.382E-6 2.635E-5 5 103
21 GO:0003097 renal water transport 4.233E-8 1.399E-6 9.961E-6 2.938E-5 3 8
22 GO:0015840 urea transport 6.346E-8 2.002E-6 1.425E-5 4.404E-5 3 9
23 GO:0045907 positive regulation of vasoconstriction 8.094E-8 2.442E-6 1.739E-5 5.617E-5 4 44
24 GO:0001990 regulation of systemic arterial blood pressure by hormone 9.718E-8 2.810E-6 2.001E-5 6.744E-5 4 46
25 GO:0009414 response to water deprivation 1.245E-7 3.456E-6 2.461E-5 8.640E-5 3 11
26 GO:0045777 positive regulation of blood pressure 1.368E-7 3.652E-6 2.600E-5 9.495E-5 4 50
27 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 2.020E-7 5.192E-6 3.697E-5 1.402E-4 4 55
28 GO:0043084 penile erection 3.425E-7 8.196E-6 5.836E-5 2.377E-4 3 15
29 GO:0042711 maternal behavior 3.425E-7 8.196E-6 5.836E-5 2.377E-4 3 15
30 GO:0060746 parental behavior 4.212E-7 9.494E-6 6.760E-5 2.923E-4 3 16
31 GO:0050891 multicellular organismal water homeostasis 4.241E-7 9.494E-6 6.760E-5 2.943E-4 4 66
32 GO:0050880 regulation of blood vessel size 5.370E-7 1.162E-5 8.271E-5 3.727E-4 5 175
33 GO:0035150 regulation of tube size 5.523E-7 1.162E-5 8.271E-5 3.833E-4 5 176
34 GO:0009415 response to water 6.131E-7 1.251E-5 8.910E-5 4.255E-4 3 18
35 GO:0008217 regulation of blood pressure 9.645E-7 1.913E-5 1.362E-4 6.694E-4 5 197
36 GO:0032535 regulation of cellular component size 9.995E-7 1.927E-5 1.372E-4 6.936E-4 6 377
37 GO:1901654 response to ketone 1.065E-6 1.993E-5 1.419E-4 7.392E-4 5 201
38 GO:0003018 vascular process in circulatory system 1.091E-6 1.993E-5 1.419E-4 7.575E-4 5 202
39 GO:0097305 response to alcohol 1.370E-6 2.439E-5 1.736E-4 9.510E-4 6 398
40 GO:0035812 renal sodium excretion 1.944E-6 3.291E-5 2.343E-4 1.349E-3 3 26
41 GO:0035813 regulation of renal sodium excretion 1.944E-6 3.291E-5 2.343E-4 1.349E-3 3 26
42 GO:0042631 cellular response to water deprivation 2.646E-6 4.371E-5 3.113E-4 1.836E-3 2 3
43 GO:0007620 copulation 2.727E-6 4.401E-5 3.134E-4 1.893E-3 3 29
44 GO:0044062 regulation of excretion 3.695E-6 5.828E-5 4.150E-4 2.564E-3 3 32
45 GO:1903524 positive regulation of blood circulation 3.814E-6 5.882E-5 4.189E-4 2.647E-3 4 114
46 GO:0007621 negative regulation of female receptivity 5.288E-6 7.490E-5 5.333E-4 3.670E-3 2 4
47 GO:0032849 positive regulation of cellular pH reduction 5.288E-6 7.490E-5 5.333E-4 3.670E-3 2 4
48 GO:0071288 cellular response to mercury ion 5.288E-6 7.490E-5 5.333E-4 3.670E-3 2 4
49 GO:0002125 maternal aggressive behavior 5.288E-6 7.490E-5 5.333E-4 3.670E-3 2 4
50 GO:0007204 positive regulation of cytosolic calcium ion concentration 5.411E-6 7.510E-5 5.348E-4 3.755E-3 5 280
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 18 input genes in category / 68 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016324 apical plasma membrane 1.311E-8 8.917E-7 4.284E-6 8.917E-7 7 335
2 GO:0016323 basolateral plasma membrane 6.754E-8 1.596E-6 7.669E-6 4.592E-6 6 244
3 GO:0045177 apical part of cell 7.043E-8 1.596E-6 7.669E-6 4.789E-6 7 428
4 GO:0009925 basal plasma membrane 7.433E-4 1.264E-2
6.071E-2
5.055E-2
 2 43
5 GO:0031303 integral component of endosome membrane 9.443E-4 1.284E-2
6.170E-2
6.421E-2
 1 1
6 GO:0045178 basal part of cell 1.640E-3 1.605E-2
7.709E-2
1.115E-1
 2 64
7 GO:0031302 intrinsic component of endosome membrane 1.888E-3 1.605E-2
7.709E-2
1.284E-1
 1 2
8 GO:0031166 integral component of vacuolar membrane 1.888E-3 1.605E-2
7.709E-2
1.284E-1
 1 2
9 GO:0031310 intrinsic component of vacuolar membrane 2.830E-3 1.750E-2
8.406E-2
1.925E-1
 1 3
10 GO:0032127 dense core granule membrane 2.830E-3 1.750E-2
8.406E-2
1.925E-1
 1 3
11 GO:0046691 intracellular canaliculus 2.830E-3 1.750E-2
8.406E-2
1.925E-1
 1 3
12 GO:0005902 microvillus 3.142E-3 1.780E-2
8.553E-2
2.136E-1
 2 89
13 GO:0020005 symbiont-containing vacuole membrane 5.653E-3 2.957E-2
1.421E-1
3.844E-1
 1 6
14 GO:0020003 symbiont-containing vacuole 6.593E-3 3.032E-2
1.456E-1
4.483E-1
 1 7
15 GO:0005911 cell-cell junction 6.688E-3 3.032E-2
1.456E-1
4.548E-1
 3 418
16 GO:0055037 recycling endosome 7.587E-3 3.225E-2
1.549E-1
5.159E-1
 2 140
17 GO:0065010 extracellular membrane-bounded organelle 8.469E-3 3.256E-2
1.564E-1
5.759E-1
 1 9
18 GO:0030430 host cell cytoplasm 9.406E-3 3.256E-2
1.564E-1
6.396E-1
 1 10
19 GO:0033655 host cell cytoplasm part 9.406E-3 3.256E-2
1.564E-1
6.396E-1
 1 10
20 GO:0030658 transport vesicle membrane 9.575E-3 3.256E-2
1.564E-1
6.511E-1
 2 158
21 GO:0043656 intracellular region of host 1.128E-2 3.485E-2
1.674E-1
7.668E-1
 1 12
22 GO:0033646 host intracellular part 1.128E-2 3.485E-2
1.674E-1
7.668E-1
 1 12
23 GO:0033643 host cell part 1.314E-2 3.886E-2
1.867E-1
8.938E-1
 1 14
24 GO:0031045 dense core granule 1.501E-2 4.238E-2
2.036E-1
1.000E0
 1 16
25 GO:0098858 actin-based cell projection 1.558E-2 4.238E-2
2.036E-1
1.000E0
 2 204
26 GO:0018995 host 1.780E-2 4.483E-2
2.154E-1
1.000E0
 1 19
27 GO:0043657 host cell 1.780E-2 4.483E-2
2.154E-1
1.000E0
 1 19
Show 22 more annotations

4: Human Phenotype [Display Chart] 8 input genes in category / 176 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000863 Central diabetes insipidus 1.654E-4 2.912E-2
1.674E-1
 2.912E-2 2 12

5: Mouse Phenotype [Display Chart] 16 input genes in category / 503 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002988 decreased urine osmolality 3.760E-12 1.891E-9 1.286E-8 1.891E-9 7 67
2 MP:0002987 abnormal urine osmolality 1.032E-11 2.595E-9 1.764E-8 5.190E-9 7 77
3 MP:0001756 abnormal urination 2.231E-9 3.741E-7 2.544E-6 1.122E-6 7 164
4 MP:0001762 polyuria 4.567E-9 5.743E-7 3.905E-6 2.297E-6 6 98
5 MP:0011941 increased fluid intake 5.823E-9 5.858E-7 3.983E-6 2.929E-6 6 102
6 MP:0011947 abnormal fluid intake 2.295E-8 1.924E-6 1.308E-5 1.154E-5 6 128
7 MP:0002593 high mean erythrocyte cell number 3.021E-8 2.171E-6 1.476E-5 1.520E-5 3 5
8 MP:0001422 abnormal drinking behavior 6.429E-8 4.042E-6 2.748E-5 3.234E-5 6 152
9 MP:0008997 increased blood osmolality 2.031E-6 1.135E-4 7.719E-4 1.022E-3 3 17
10 MP:0009643 abnormal urine homeostasis 3.126E-6 1.553E-4 1.056E-3 1.572E-3 7 472
11 MP:0008996 abnormal blood osmolality 3.396E-6 1.553E-4 1.056E-3 1.708E-3 3 20
12 MP:0011471 decreased urine creatinine level 6.007E-6 2.518E-4 1.712E-3 3.021E-3 3 24
13 MP:0011417 abnormal renal transport 6.819E-6 2.639E-4 1.794E-3 3.430E-3 3 25
14 MP:0005565 increased blood urea nitrogen level 7.697E-6 2.765E-4 1.880E-3 3.872E-3 5 192
15 MP:0011469 abnormal urine creatinine level 1.198E-5 4.018E-4 2.731E-3 6.026E-3 3 30
16 MP:0002136 abnormal kidney physiology 2.780E-5 8.740E-4 5.942E-3 1.398E-2 6 430
17 MP:0005265 abnormal blood urea nitrogen level 3.103E-5 8.836E-4 6.007E-3 1.561E-2 5 256
18 MP:0009644 uremia 3.162E-5 8.836E-4 6.007E-3 1.590E-2 5 257
19 MP:0011305 dilated kidney calyx 6.234E-5 1.650E-3 1.122E-2 3.136E-2 2 8
20 MP:0011468 abnormal urine amino acid level 7.156E-5 1.800E-3 1.224E-2 3.599E-2 3 54
21 MP:0011443 abnormal renal water transport 1.000E-4 2.287E-3 1.555E-2
5.030E-2
 2 10
22 MP:0011444 abnormal renal water homeostasis 1.000E-4 2.287E-3 1.555E-2
5.030E-2
 2 10
23 MP:0003918 decreased kidney weight 1.136E-4 2.484E-3 1.689E-2
5.714E-2
 3 63
24 MP:0013285 abnormal renal filtration 1.191E-4 2.496E-3 1.697E-2
5.989E-2
 3 64
25 MP:0004195 abnormal kidney calyx morphology 1.464E-4 2.946E-3 2.003E-2
7.365E-2
 2 12
26 MP:0011465 abnormal urine urea nitrogen level 2.323E-4 4.494E-3 3.055E-2
1.168E-1
 2 15
27 MP:0002608 increased hematocrit 2.964E-4 5.522E-3 3.754E-2
1.491E-1
 3 87
28 MP:0005128 decreased adrenocorticotropin level 3.376E-4 6.064E-3 4.123E-2
1.698E-1
 2 18
29 MP:0001429 dehydration 4.467E-4 7.498E-3
5.098E-2
2.247E-1
 3 100
30 MP:0003131 increased erythrocyte cell number 4.599E-4 7.498E-3
5.098E-2
2.313E-1
 3 101
31 MP:0004851 increased testis weight 4.621E-4 7.498E-3
5.098E-2
2.324E-1
 2 21
32 MP:0002989 small kidney 5.253E-4 8.257E-3
5.614E-2
2.642E-1
 4 256
33 MP:0005556 abnormal renal filtration rate 7.682E-4 1.171E-2
7.961E-2
3.864E-1
 2 27
34 MP:0004193 abnormal kidney papilla morphology 8.265E-4 1.223E-2
8.314E-2
4.158E-1
 2 28
35 MP:0001596 hypotension 9.495E-4 1.342E-2
9.126E-2
4.776E-1
 2 30
36 MP:0001360 abnormal social investigation 9.607E-4 1.342E-2
9.126E-2
4.832E-1
 3 130
37 MP:0004192 abnormal kidney pyramid morphology 1.014E-3 1.379E-2
9.372E-2
5.101E-1
 2 31
38 MP:0000639 abnormal adrenal gland morphology 1.072E-3 1.419E-2
9.645E-2
5.391E-1
 3 135
39 MP:0002707 abnormal kidney weight 1.215E-3 1.567E-2
1.066E-1
6.113E-1
 3 141
40 MP:0005568 increased circulating total protein level 1.293E-3 1.626E-2
1.105E-1
6.503E-1
 2 35
41 MP:0005523 decreased circulating atrial natriuretic factor 1.545E-3 1.896E-2
1.289E-1
7.772E-1
 1 1
42 MP:0003966 abnormal adrenocorticotropin level 1.772E-3 2.122E-2
1.443E-1
8.914E-1
 2 41
43 MP:0001426 polydipsia 1.859E-3 2.175E-2
1.479E-1
9.351E-1
 2 42
44 MP:0002706 abnormal kidney size 2.287E-3 2.615E-2
1.778E-1
1.000E0
 4 380
45 MP:0011844 kidney collecting duct atrophy 3.088E-3 3.452E-2
2.347E-1
1.000E0
 1 2
46 MP:0001937 abnormal sexual maturation 3.884E-3 4.085E-2
2.777E-1
1.000E0
 2 61
47 MP:0011425 abnormal kidney interstitium morphology 4.010E-3 4.085E-2
2.777E-1
1.000E0
 2 62
48 MP:0004970 kidney atrophy 4.399E-3 4.085E-2
2.777E-1
1.000E0
 2 65
49 MP:0005458 increased percent body fat/body weight 4.399E-3 4.085E-2
2.777E-1
1.000E0
 2 65
50 MP:0011741 increased urine nitrite level 4.629E-3 4.085E-2
2.777E-1
1.000E0
 1 3
Show 45 more annotations

6: Domain [Display Chart] 18 input genes in category / 73 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR022357 MIP CS InterPro 6.482E-17 4.732E-15 2.306E-14 4.732E-15 6 10
2 PF00230 MIP Pfam 9.249E-16 1.874E-14 9.137E-14 6.751E-14 6 14
3 PS00221 MIP PROSITE 9.249E-16 1.874E-14 9.137E-14 6.751E-14 6 14
4 IPR000425 MIP InterPro 1.541E-15 1.874E-14 9.137E-14 1.125E-13 6 15
5 1.20.1080.10 - Gene3D 1.541E-15 1.874E-14 9.137E-14 1.125E-13 6 15
6 IPR023271 Aquaporin-like InterPro 1.541E-15 1.874E-14 9.137E-14 1.125E-13 6 15
7 IPR001817 Vasoprsn rcpt InterPro 7.438E-9 7.756E-8 3.781E-7 5.429E-7 3 5
8 PF03253 UT Pfam 8.718E-7 5.304E-6 2.585E-5 6.364E-5 2 2
9 IPR004937 Urea transporter InterPro 8.718E-7 5.304E-6 2.585E-5 6.364E-5 2 2
10 PF08983 DUF1856 Pfam 8.718E-7 5.304E-6 2.585E-5 6.364E-5 2 2
11 IPR015076 DUF1856 InterPro 8.718E-7 5.304E-6 2.585E-5 6.364E-5 2 2
12 SM01164 DUF1856 SMART 8.718E-7 5.304E-6 2.585E-5 6.364E-5 2 2
13 IPR029020 Ammonium/urea transptr InterPro 1.826E-5 9.520E-5 4.640E-4 1.333E-3 2 7
14 1.10.3430.10 - Gene3D 1.826E-5 9.520E-5 4.640E-4 1.333E-3 2 7
15 IPR001224 Vprs V1A rcpt InterPro 9.608E-4 3.049E-3 1.486E-2
7.014E-2
 1 1
16 IPR023276 Aquaporin 5 InterPro 9.608E-4 3.049E-3 1.486E-2
7.014E-2
 1 1
17 IPR033843 CPAH InterPro 9.608E-4 3.049E-3 1.486E-2
7.014E-2
 1 1
18 IPR000628 Vprs rcpt V1B InterPro 9.608E-4 3.049E-3 1.486E-2
7.014E-2
 1 1
19 IPR023275 Aquaporin 3 InterPro 9.608E-4 3.049E-3 1.486E-2
7.014E-2
 1 1
20 2.130.10.120 - Gene3D 9.608E-4 3.049E-3 1.486E-2
7.014E-2
 1 1
21 IPR023254 Aquaporin 6 InterPro 9.608E-4 3.049E-3 1.486E-2
7.014E-2
 1 1
22 IPR023274 Aquaporin 1 InterPro 9.608E-4 3.049E-3 1.486E-2
7.014E-2
 1 1
23 IPR002062 Oxytocn rcpt InterPro 9.608E-4 3.049E-3 1.486E-2
7.014E-2
 1 1
24 PD001676 Neurhyp horm ProDom 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
25 IPR003909 GPR37 orph InterPro 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
26 IPR023302 Pept S9A N InterPro 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
27 PF00446 GnRH Pfam 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
28 IPR002470 Peptidase S9A InterPro 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
29 PF00220 Hormone 4 Pfam 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
30 IPR019792 Gonadoliberin I InterPro 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
31 PF00184 Hormone 5 Pfam 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
32 IPR022423 Neurohypophysial hormone CS InterPro 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
33 PS00473 GNRH PROSITE 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
34 SM00003 NH SMART 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
35 PS00264 NEUROHYPOPHYS HORM PROSITE 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
36 2.60.9.10 - Gene3D 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
37 IPR002012 GnRH InterPro 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
38 PF02897 Peptidase S9 N Pfam 1.921E-3 3.690E-3 1.799E-2
1.402E-1
 1 2
39 IPR001186 Brdyknn 1 rcpt InterPro 2.880E-3 5.255E-3 2.562E-2
2.102E-1
 1 3
40 IPR000190 ATII AT1 rcpt InterPro 2.880E-3 5.255E-3 2.562E-2
2.102E-1
 1 3
41 IPR002471 Pept S9 AS InterPro 3.838E-3 6.671E-3 3.252E-2
2.802E-1
 1 4
42 IPR000981 Neurhyp horm InterPro 3.838E-3 6.671E-3 3.252E-2
2.802E-1
 1 4
43 IPR000248 ATII rcpt InterPro 4.795E-3 7.956E-3 3.878E-2
3.500E-1
 1 5
44 PS00708 PRO ENDOPEP SER PROSITE 4.795E-3 7.956E-3 3.878E-2
3.500E-1
 1 5
45 IPR001277 CXCR4/ACKR2 InterPro 6.707E-3 1.088E-2
5.304E-2
4.896E-1
 1 7
46 3.30.70.340 - Gene3D 7.662E-3 1.165E-2
5.680E-2
5.593E-1
 1 8
47 PF02244 Propep M14 Pfam 7.662E-3 1.165E-2
5.680E-2
5.593E-1
 1 8
48 IPR003146 M14A act pep InterPro 7.662E-3 1.165E-2
5.680E-2
5.593E-1
 1 8
49 IPR001375 Peptidase S9 InterPro 1.052E-2 1.536E-2
7.487E-2
7.680E-1
 1 11
50 PF00326 Peptidase S9 Pfam 1.052E-2 1.536E-2
7.487E-2
7.680E-1
 1 11
Show 45 more annotations

7: Pathway [Display Chart] 16 input genes in category / 112 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269945 Passive transport by Aquaporins BioSystems: REACTOME 2.647E-15 2.965E-13 1.571E-12 2.965E-13 6 13
2 1269944 Aquaporin-mediated transport BioSystems: REACTOME 1.620E-13 8.225E-12 4.360E-11 1.814E-11 7 52
3 PW:0000419 water transport Pathway Ontology 2.203E-13 8.225E-12 4.360E-11 2.468E-11 5 9
4 1269549 Vasopressin-like receptors BioSystems: REACTOME 2.724E-11 7.628E-10 4.043E-9 3.051E-9 4 6
5 PW:0000229 G protein signaling via Galphaq family Pathway Ontology 1.807E-9 4.047E-8 2.145E-7 2.024E-7 4 14
6 PW:0000491 vasopressin signaling Pathway Ontology 4.286E-9 8.000E-8 4.240E-7 4.800E-7 4 17
7 1309124 Defective AVP causes neurohypophyseal diabetes insipidus (NDI) BioSystems: REACTOME 6.961E-9 1.114E-7 5.903E-7 7.796E-7 3 4
8 PW:0000712 vasopressin signaling pathway via receptor type 1 Pathway Ontology 1.739E-8 2.434E-7 1.290E-6 1.947E-6 3 5
9 1309123 SLC transporter disorders BioSystems: REACTOME 6.076E-8 7.562E-7 4.008E-6 6.806E-6 3 7
10 1269545 Class A/1 (Rhodopsin-like receptors) BioSystems: REACTOME 6.792E-8 7.607E-7 4.032E-6 7.607E-6 7 322
11 1269546 Peptide ligand-binding receptors BioSystems: REACTOME 7.731E-8 7.872E-7 4.172E-6 8.659E-6 6 188
12 1269578 G alpha (q) signalling events BioSystems: REACTOME 8.763E-8 8.178E-7 4.335E-6 9.814E-6 6 192
13 1269946 Vasopressin regulates renal water homeostasis via Aquaporins BioSystems: REACTOME 2.178E-7 1.877E-6 9.946E-6 2.440E-5 4 43
14 1269544 GPCR ligand binding BioSystems: REACTOME 7.145E-7 5.716E-6 3.030E-5 8.003E-5 7 455
15 SMP00153 Quinapril Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
16 SMP00152 Perindopril Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
17 SMP00150 Lisinopril Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
18 SMP00154 Ramipril Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
19 SMP00151 Moexipril Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
20 SMP00147 Cilazapril Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
21 SMP00148 Enalapril Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
22 SMP00156 Spirapril Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
23 SMP00155 Rescinnamine Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
24 SMP00157 Trandolapril Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
25 SMP00149 Fosinopril Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
26 SMP00145 Benazepril Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
27 SMP00146 Captopril Pathway SMPDB 1.017E-5 4.219E-5 2.236E-4 1.139E-3 3 34
28 1269592 Gastrin-CREB signalling pathway via PKC and MAPK BioSystems: REACTOME 1.205E-5 4.821E-5 2.555E-4 1.350E-3 6 446
29 143700 Vasopressin-regulated water reabsorption BioSystems: KEGG 2.234E-5 8.626E-5 4.572E-4 2.502E-3 3 44
30 1311074 Phospholipase D signaling pathway BioSystems: KEGG 2.960E-5 1.105E-4 5.857E-4 3.315E-3 4 146
31 83050 Calcium signaling pathway BioSystems: KEGG 7.009E-5 2.532E-4 1.342E-3 7.850E-3 4 182
32 P04395 Vasopressin synthesis PantherDB 8.459E-5 2.961E-4 1.569E-3 9.475E-3 2 11
33 SMP00134 Spironolactone Pathway SMPDB 1.198E-4 3.833E-4 2.032E-3 1.342E-2 2 13
34 PW:0000713 vasopressin signaling pathway via receptor type 2 Pathway Ontology 1.198E-4 3.833E-4 2.032E-3 1.342E-2 2 13
35 SMP00135 Eplerenone Pathway SMPDB 1.198E-4 3.833E-4 2.032E-3 1.342E-2 2 13
36 1268932 Disorders of transmembrane transporters BioSystems: REACTOME 1.249E-4 3.887E-4 2.060E-3 1.399E-2 3 78
37 SMP00133 Amiloride Pathway SMPDB 1.396E-4 4.116E-4 2.182E-3 1.564E-2 2 14
38 SMP00132 Triamterene Pathway SMPDB 1.396E-4 4.116E-4 2.182E-3 1.564E-2 2 14
39 83053 Neuroactive ligand-receptor interaction BioSystems: KEGG 3.582E-4 1.029E-3 5.452E-3 4.012E-2 4 278
40 83075 Renin-angiotensin system BioSystems: KEGG 3.856E-4 1.080E-3 5.723E-3 4.319E-2 2 23
41 96530 Vascular smooth muscle contraction BioSystems: KEGG 4.572E-4 1.249E-3 6.620E-3
5.121E-2
 3 121
42 137918 Stabilization and expansion of the E-cadherin adherens junction BioSystems: Pathway Interaction Database 1.174E-3 3.130E-3 1.659E-2
1.315E-1
 2 40
43 PW:0000530 Angiotensin III signaling through the AT1 receptor Pathway Ontology 2.569E-3 6.691E-3 3.546E-2
2.877E-1
 1 2
44 1222951 Renin secretion BioSystems: KEGG 3.072E-3 7.821E-3 4.145E-2
3.441E-1
 2 65
45 PW:0000527 Angiotensin II signaling through the AT1 receptor Pathway Ontology 3.851E-3 9.584E-3
5.080E-2
4.313E-1
 1 3
46 PW:0000494 oxytocin signaling Pathway Ontology 5.131E-3 1.223E-2
6.481E-2
5.747E-1
 1 4
47 PW:0000457 angiotensin III signaling Pathway Ontology 5.131E-3 1.223E-2
6.481E-2
5.747E-1
 1 4
48 1269907 SLC-mediated transmembrane transport BioSystems: REACTOME 5.434E-3 1.268E-2
6.720E-2
6.086E-1
 3 287
49 1427859 Cargo recognition for clathrin-mediated endocytosis BioSystems: REACTOME 6.985E-3 1.597E-2
8.463E-2
7.824E-1
 2 99
50 1269923 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds BioSystems: REACTOME 7.972E-3 1.786E-2
9.464E-2
8.928E-1
 2 106
Show 45 more annotations

8: Pubmed [Display Chart] 18 input genes in category / 3951 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12522663 Aquaporin expression in developing human teeth and selected orofacial tissues. Pubmed 1.265E-17 4.249E-14 3.764E-13 5.000E-14 5 5
2 26847765 Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. Pubmed 2.151E-17 4.249E-14 3.764E-13 8.498E-14 6 15
3 19367412 Expression patterns of the aquaporin gene family during renal development: influence of genetic variability. Pubmed 7.971E-17 1.050E-13 9.301E-13 3.150E-13 6 18
4 9757370 Aquaporin molecular biology and clinical abnormalities of the water transport channels. Pubmed 7.081E-16 6.994E-13 6.196E-12 2.798E-12 5 8
5 12031518 Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea. Pubmed 1.593E-15 7.439E-13 6.590E-12 6.293E-12 5 9
6 10788316 Expression of mRNAs of the aquaporin family in mouse oocytes and embryos. Pubmed 1.593E-15 7.439E-13 6.590E-12 6.293E-12 5 9
7 11066060 mRNAs encoding aquaporins are present during murine preimplantation development. Pubmed 1.593E-15 7.439E-13 6.590E-12 6.293E-12 5 9
8 10318966 Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia. Pubmed 3.184E-15 7.439E-13 6.590E-12 1.258E-11 5 10
9 12084581 Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
10 11001937 Functional impairment of lens aquaporin in two families with dominantly inherited cataracts. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
11 14701836 Aquaporin-1, nothing but a water channel. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
12 11076974 The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
13 9829975 Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
14 18501347 Functional characterization of a human aquaporin 0 mutation that leads to a congenital dominant lens cataract. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
15 21251984 Water permeability and characterization of aquaporin-11. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
16 18511455 Novel variants in human Aquaporin-4 reduce cellular water permeability. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
17 7530250 Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
18 1373524 Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
19 16596446 Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
20 15948717 Purification and functional characterization of aquaporin-8. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
21 10564231 Functional and molecular characterization of the human neutral solute channel aquaporin-9. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
22 11573934 Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
23 9405233 Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
24 18202181 Mechanism of selectivity in aquaporins and aquaglyceroporins. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
25 18762715 Functional characterization of human aquaporin 9 as a facilitative glycerol carrier. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
26 9806845 Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
27 1510932 Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
28 10510269 Functional characterization and localization of AQP3 in the human colon. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
29 17178220 Identification of arylsulfonamides as Aquaporin 4 inhibitors. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
30 11034202 Structural determinants of water permeation through aquaporin-1. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
31 9369468 Mercury-sensitive residues and pore site in AQP3 water channel. Pubmed 5.837E-15 7.439E-13 6.590E-12 2.306E-11 5 11
32 9268644 Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. Pubmed 3.452E-14 4.133E-12 3.661E-11 1.364E-10 4 4
33 15100356 Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B. Pubmed 3.452E-14 4.133E-12 3.661E-11 1.364E-10 4 4
34 12486173 Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. Pubmed 1.725E-13 1.894E-11 1.678E-10 6.817E-10 4 5
35 15003543 Expression of aquaporin isoforms during human and mouse tooth development. Pubmed 1.725E-13 1.894E-11 1.678E-10 6.817E-10 4 5
36 17377981 Functional expression of aquaporins in embryonic, postnatal, and adult mouse lenses. Pubmed 1.725E-13 1.894E-11 1.678E-10 6.817E-10 4 5
37 10232700 Lessons on renal physiology from transgenic mice lacking aquaporin water channels. Pubmed 5.175E-13 5.526E-11 4.895E-10 2.045E-9 4 6
38 25721378 Expression of aquaporin-1, aquaporin-3, and aquaporin-5 correlates with nodal metastasis in colon cancer. Pubmed 8.789E-11 7.388E-9 6.545E-8 3.472E-7 3 3
39 28766180 The expression of water channel proteins during human salivary gland development: a topographic study of aquaporins 1, 3 and 5. Pubmed 8.789E-11 7.388E-9 6.545E-8 3.472E-7 3 3
40 18247144 Aquaporin expression in the human intervertebral disc. Pubmed 8.789E-11 7.388E-9 6.545E-8 3.472E-7 3 3
41 15557451 Aquaporin-dependent water permeation at the mouse ocular surface: in vivo microfluorimetric measurements in cornea and conjunctiva. Pubmed 8.789E-11 7.388E-9 6.545E-8 3.472E-7 3 3
42 14514735 Aquaporin expression in normal human kidney and in renal disease. Pubmed 8.789E-11 7.388E-9 6.545E-8 3.472E-7 3 3
43 11443343 A phylogenetic framework for the aquaporin family in eukaryotes. Pubmed 8.789E-11 7.388E-9 6.545E-8 3.472E-7 3 3
44 29279852 The Expression of AQP5 and UTs in the Sweat Glands of Uremic Patients. Pubmed 8.789E-11 7.388E-9 6.545E-8 3.472E-7 3 3
45 19136711 In situ fluorescence measurement of tear film [Na+], [K+], [Cl-], and pH in mice shows marked hypertonicity in aquaporin-5 deficiency. Pubmed 8.789E-11 7.388E-9 6.545E-8 3.472E-7 3 3
46 21237499 Relationship of aquaporin 1, 3, and 5 expression in lung cancer cells to cellular differentiation, invasive growth, and metastasis potential. Pubmed 8.789E-11 7.388E-9 6.545E-8 3.472E-7 3 3
47 10337625 Cloning and characterization of murine Aqp5: evidence for a conserved aquaporin gene cluster. Pubmed 8.789E-11 7.388E-9 6.545E-8 3.472E-7 3 3
48 21178974 Vasopressin-dependent coupling between sodium transport and water flow in a mouse cortical collecting duct cell line. Pubmed 3.514E-10 2.353E-8 2.085E-7 1.389E-6 3 4
49 26261083 Expression pattern of aquaporins in patients with primary nephrotic syndrome with edema. Pubmed 3.514E-10 2.353E-8 2.085E-7 1.389E-6 3 4
50 21063116 Molecular analysis of aquaporin genes 1 to 4 in patients with Menière's disease. Pubmed 3.514E-10 2.353E-8 2.085E-7 1.389E-6 3 4
Show 45 more annotations

9: Interaction [Display Chart] 16 input genes in category / 227 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:AVP AVP interactions 8.991E-9 2.041E-6 1.225E-5 2.041E-6 4 28
2 int:AVPR1B AVPR1B interactions 4.590E-6 3.473E-4 2.085E-3 1.042E-3 2 4
3 int:AVPR1A AVPR1A interactions 4.590E-6 3.473E-4 2.085E-3 1.042E-3 2 4
4 int:OXTR OXTR interactions 7.646E-6 4.339E-4 2.605E-3 1.736E-3 2 5
5 int:OXT OXT interactions 4.192E-5 1.903E-3 1.143E-2 9.516E-3 2 11
6 int:AGT AGT interactions 2.855E-4 9.941E-3
5.969E-2
6.482E-2
 2 28
7 int:ATE1 ATE1 interactions 3.065E-4 9.941E-3
5.969E-2
6.958E-2
 2 29
8 int:GRK5 GRK5 interactions 5.000E-4 1.419E-2
8.519E-2
1.135E-1
 3 177
9 int:CREB3 CREB3 interactions 9.657E-4 2.332E-2
1.400E-1
2.192E-1
 3 222
10 int:GPRASP1 GPRASP1 interactions 1.027E-3 2.332E-2
1.400E-1
2.332E-1
 2 53
11 int:FNTB FNTB interactions 1.146E-3 2.366E-2
1.420E-1
2.602E-1
 2 56
12 int:GNRH2 GNRH2 interactions 1.807E-3 3.155E-2
1.894E-1
4.102E-1
 1 2
13 int:SLC14A2 SLC14A2 interactions 1.807E-3 3.155E-2
1.894E-1
4.102E-1
 1 2
14 int:PICK1 PICK1 interactions 2.497E-3 3.844E-2
2.308E-1
5.669E-1
 2 83
15 int:GJA8 GJA8 interactions 2.709E-3 3.844E-2
2.308E-1
6.150E-1
 1 3
16 int:SLC5A2 SLC5A2 interactions 2.709E-3 3.844E-2
2.308E-1
6.150E-1
 1 3
Show 11 more annotations

10: Cytoband [Display Chart] 18 input genes in category / 15 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12q13 12q13 6.574E-6 9.861E-5 3.272E-4 9.861E-5 3 71
2 18q11-q12 18q11-q12 5.193E-4 1.947E-3 6.462E-3 7.790E-3 1 1
3 12q14-q15 12q14-q15 5.193E-4 1.947E-3 6.462E-3 7.790E-3 1 1
4 18q12.1-q21.1 18q12.1-q21.1 5.193E-4 1.947E-3 6.462E-3 7.790E-3 1 1
5 20p13 20p13 1.272E-3 3.817E-3 1.267E-2 1.908E-2 2 102
6 6q22 6q22 4.147E-3 8.887E-3 2.949E-2
6.221E-2
 1 8
7 12q12-q13 12q12-q13 4.147E-3 8.887E-3 2.949E-2
6.221E-2
 1 8
8 8q13.2 8q13.2 5.698E-3 1.068E-2 3.545E-2
8.548E-2
 1 11
9 3p25 3p25 8.794E-3 1.466E-2 4.863E-2
1.319E-1
 1 17
10 9p13 9p13 1.188E-2 1.782E-2
5.913E-2
1.782E-1
 1 23
11 7q31 7q31 1.393E-2 1.900E-2
6.304E-2
2.090E-1
 1 27
12 7p14 7p14 1.547E-2 1.934E-2
6.416E-2
2.320E-1
 1 30
13 3q24 3q24 1.700E-2 1.962E-2
6.510E-2
2.551E-1
 1 33
14 1q32 1q32 2.515E-2 2.695E-2
8.941E-2
3.772E-1
 1 49
Show 9 more annotations

11: Transcription Factor Binding Site [Display Chart] 15 input genes in category / 76 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 17 input genes in category / 9 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 305 Aquaporins genenames.org 7.353E-16 6.618E-15 1.872E-14 6.618E-15 6 14
2 259 Arginine vasopressin and oxytocin receptors genenames.org 2.709E-9 1.219E-8 3.448E-8 2.438E-8 3 4
3 454 Blood group antigens genenames.org 5.162E-6 1.549E-5 4.381E-5 4.646E-5 3 37
4 221 X-linked mental retardation|Angiotensin receptors genenames.org 1.868E-3 4.203E-3 1.189E-2 1.681E-2 1 2
5 522 LIM class homeoboxes genenames.org 1.116E-2 2.009E-2
5.682E-2
1.004E-1
 1 12
6 1321 Carboxypeptidases genenames.org 1.945E-2 2.598E-2
7.349E-2
1.751E-1
 1 21
7 542 Endogenous ligands genenames.org 2.020E-2 2.598E-2
7.349E-2
1.818E-1
 2 237
Show 2 more annotations

13: Coexpression [Display Chart] 18 input genes in category / 1175 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20460173-ImmPortCytokineReceptors Human Immune Kong10 308genes ImmPort CytokineReceptors GeneSigDB 7.633E-5 4.561E-2
3.488E-1
8.969E-2
 4 303
2 19303107-Table2 Mouse Bladder Price09 20genes GeneSigDB 9.699E-5 4.561E-2
3.488E-1
1.140E-1
 2 19
3 M1676 Genes whose expression negatively correlated with that of SMARCA2 [GeneID=6595] in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.422E-4 4.561E-2
3.488E-1
1.671E-1
 4 356
4 M2005 Genes with intermediate-CpG-density promoters (ICP) bearing bivalent histone H3 methylation mark (H3K4me3 and H3K27me3) in embryonic stem cells (ES). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.553E-4 4.561E-2
3.488E-1
1.825E-1
 3 137
5 M4872 Genes up-regulated in mature plasma cells compared with plasmablastic B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.159E-4 4.995E-2
3.819E-1
2.537E-1
 4 397
6 M1351 Genes down-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 48 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.876E-4 4.995E-2
3.819E-1
3.379E-1
 4 428
7 18223198-Table3 Human Brain Chen-Plotkin08 40genes FTLD-U GeneSigDB 2.975E-4 4.995E-2
3.819E-1
3.496E-1
 2 33
Show 2 more annotations

14: Coexpression Atlas [Display Chart] 18 input genes in category / 1287 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingLowerUrinaryTract P1 bladder 500 J DevelopingLowerUrinaryTract P1 bladder J emap-30374 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.255E-5 5.772E-3 4.466E-2 1.615E-2 5 390
2 gudmap developingLowerUrinaryTract P1 ureter 500 DevelopingLowerUrinaryTract P1 ureter emap-30363 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.286E-5 5.772E-3 4.466E-2 1.656E-2 5 392
3 gudmap kidney adult CortVasc Tie2 k2 100 kidney adult CortVasc Tie2 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.345E-5 5.772E-3 4.466E-2 1.731E-2 2 7
4 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k5 1000 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.114E-5 1.646E-2
1.273E-1
6.582E-2
 3 89
5 gudmap developingLowerUrinaryTract P1 bladder J 500 k3 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.241E-5 1.864E-2
1.442E-1
9.319E-2
 3 100
6 gudmap developingLowerUrinaryTract adult ureter 200 k4 DevelopingLowerUrinaryTract adult ureter emap-29479 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.210E-4 1.970E-2
1.524E-1
1.557E-1
 2 20
7 gudmap developingLowerUrinaryTract P1 bladder B 1000 k3 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.339E-4 1.970E-2
1.524E-1
1.723E-1
 3 123
8 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 200 k1 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.608E-4 1.970E-2
1.524E-1
2.070E-1
 2 23
9 gudmap kidney adult CortVasc Tie2 k2 200 kidney adult CortVasc Tie2 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.754E-4 1.970E-2
1.524E-1
2.257E-1
 2 24
10 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 200 k2 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.905E-4 1.970E-2
1.524E-1
2.452E-1
 2 25
11 gudmap developingLowerUrinaryTract P1 ureter 200 k1 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.227E-4 1.970E-2
1.524E-1
2.866E-1
 2 27
12 gudmap developingLowerUrinaryTract adult bladder 500 DevelopingLowerUrinaryTract adult bladder emap-29457 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.257E-4 1.970E-2
1.524E-1
2.905E-1
 4 379
13 gudmap developingLowerUrinaryTract P1 bladder 500 B DevelopingLowerUrinaryTract P1 bladder B emap-30374 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.396E-4 1.970E-2
1.524E-1
3.084E-1
 4 385
14 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 200 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.501E-4 1.970E-2
1.524E-1
3.219E-1
 3 152
15 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 100 k2 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.573E-4 1.970E-2
1.524E-1
3.312E-1
 2 29
16 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 1000 k1 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.751E-4 1.970E-2
1.524E-1
3.541E-1
 3 157
17 gudmap developingLowerUrinaryTract P1 ureter 200 DevelopingLowerUrinaryTract P1 ureter emap-30363 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.751E-4 1.970E-2
1.524E-1
3.541E-1
 3 157
18 gudmap developingLowerUrinaryTract P1 bladder 200 B DevelopingLowerUrinaryTract P1 bladder B emap-30374 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.908E-4 1.970E-2
1.524E-1
3.743E-1
 3 160
19 gudmap developingLowerUrinaryTract adult bladder 200 DevelopingLowerUrinaryTract adult bladder emap-29457 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.908E-4 1.970E-2
1.524E-1
3.743E-1
 3 160
20 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 500 k3 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.139E-4 2.020E-2
1.563E-1
4.040E-1
 2 32
21 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 500 k1 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.979E-4 2.439E-2
1.887E-1
5.121E-1
 2 36
22 gudmap developingLowerUrinaryTract P1 bladder B 200 k3 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.436E-4 2.595E-2
2.008E-1
5.709E-1
 2 38
23 gudmap kidney adult RenMedVasc Tie2 k4 100 kidney adult RenMedVasc Tie2 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 4.917E-4 2.751E-2
2.129E-1
6.328E-1
 2 40
24 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 k1 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.684E-4 2.887E-2
2.234E-1
7.315E-1
 2 43
25 PCBC ratio EB-blastocyst vs EB-cbCD34 500 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 500 PCBC 5.794E-4 2.887E-2
2.234E-1
7.457E-1
 4 486
26 gudmap developingLowerUrinaryTract adult ureter 500 k4 DevelopingLowerUrinaryTract adult ureter emap-29479 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.952E-4 2.887E-2
2.234E-1
7.660E-1
 2 44
27 Arv EB-LF 500 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 500 PCBC 6.399E-4 2.887E-2
2.234E-1
8.235E-1
 4 499
28 gudmap developingLowerUrinaryTract adult bladder 200 k2 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 6.505E-4 2.887E-2
2.234E-1
8.373E-1
 2 46
29 gudmap developingLowerUrinaryTract P1 ureter 200 k3 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 6.505E-4 2.887E-2
2.234E-1
8.373E-1
 2 46
30 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 1000 k4 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.791E-4 2.913E-2
2.254E-1
8.740E-1
 2 47
31 gudmap developingLowerUrinaryTract P1 bladder J 200 k1 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 7.083E-4 2.941E-2
2.275E-1
9.116E-1
 2 48
32 gudmap developingLowerUrinaryTract adult bladder 200 k1 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 7.685E-4 3.091E-2
2.391E-1
9.890E-1
 2 50
33 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 1000 k1 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.994E-4 3.118E-2
2.412E-1
1.000E0
 2 51
34 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 1000 k3 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 8.276E-4 3.133E-2
2.424E-1
1.000E0
 3 229
35 gudmap developingLowerUrinaryTract adult bladder 500 k1 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.105E-3 4.063E-2
3.144E-1
1.000E0
 2 60
36 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 1000 k2 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.234E-3 4.412E-2
3.414E-1
1.000E0
 3 263
Show 31 more annotations

15: Computational [Display Chart] 16 input genes in category / 111 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M10181 MODULE 416 Genes in the cancer module 416. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.773E-6 6.164E-4 3.261E-3 6.408E-4 3 23
2 M18076 MODULE 367 Genes in the cancer module 367. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.184E-5 6.164E-4 3.261E-3 1.315E-3 3 29
3 M6672 MODULE 146 Genes in the cancer module 146. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.666E-5 6.164E-4 3.261E-3 1.849E-3 4 102
4 M491 MODULE 288 Genes in the cancer module 288. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.499E-5 6.934E-4 3.669E-3 2.774E-3 3 37
5 M2127 GCM FANCC Neighborhood of FANCC MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.164E-4 1.868E-2
9.885E-2
1.017E-1
 3 124
6 M3544 MODULE 134 Genes in the cancer module 134. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.010E-3 1.868E-2
9.885E-2
1.121E-1
 2 30
Show 1 more annotation

16: MicroRNA [Display Chart] 18 input genes in category / 257 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-122*:mirSVR lowEffct hsa-miR-122*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.430E-4 3.676E-2
2.253E-1
 3.676E-2 3 414

17: Drug [Display Chart] 18 input genes in category / 4977 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID011979316 vasopressin Stitch 5.239E-27 2.608E-23 2.370E-22 2.608E-23 16 388
2 CID000027991 DDAVP Stitch 6.192E-24 1.541E-20 1.401E-19 3.082E-20 12 123
3 CID003033874 naphthalene-diisocyanate Stitch 4.353E-22 7.222E-19 6.565E-18 2.167E-18 10 62
4 CID000119369 OPC-31260 Stitch 1.685E-21 2.096E-18 1.906E-17 8.386E-18 9 38
5 CID000011136 PCMBS Stitch 3.033E-17 3.019E-14 2.744E-13 1.509E-13 9 105
6 CID005287663 AC1NRA2F Stitch 4.082E-16 3.386E-13 3.078E-12 2.031E-12 7 36
7 CID000096799 L-Ala-L-Val Stitch 9.100E-16 6.470E-13 5.882E-12 4.529E-12 7 40
8 CID000007099 proflavine Stitch 1.486E-15 9.242E-13 8.401E-12 7.394E-12 8 88
9 CID000024182 HgCl Stitch 4.177E-15 2.310E-12 2.100E-11 2.079E-11 7 49
10 CID000002720 thiazide Stitch 5.916E-15 2.944E-12 2.676E-11 2.944E-11 8 104
11 CID000195374 Hydrin 1 Stitch 2.081E-14 8.630E-12 7.845E-11 1.036E-10 5 9
12 CID003083001 AC1MIZWH Stitch 2.081E-14 8.630E-12 7.845E-11 1.036E-10 5 9
13 CID006327644 pyroantimonate Stitch 3.513E-14 1.345E-11 1.223E-10 1.749E-10 6 28
14 CID000004788 phloretin Stitch 3.931E-14 1.398E-11 1.270E-10 1.957E-10 8 131
15 CID000447364 3-nitro-4-hydroxyphenylacetic acid Stitch 1.828E-12 5.595E-10 5.086E-9 9.097E-9 7 113
16 CID000158348 SR121463 Stitch 1.911E-12 5.595E-10 5.086E-9 9.512E-9 5 19
17 CID000114904 OPC-21268 Stitch 1.911E-12 5.595E-10 5.086E-9 9.512E-9 5 19
18 CID000008998 meso-erythritol Stitch 2.381E-12 6.582E-10 5.983E-9 1.185E-8 6 54
19 CID003083288 L-366,509 Stitch 4.044E-12 9.374E-10 8.521E-9 2.013E-8 4 6
20 CID005008461 Hydrin 2 Stitch 4.044E-12 9.374E-10 8.521E-9 2.013E-8 4 6
21 CID006918320 L-371,257 Stitch 4.044E-12 9.374E-10 8.521E-9 2.013E-8 4 6
22 CID000024774 Vasotocin Stitch 4.144E-12 9.374E-10 8.521E-9 2.062E-8 6 59
23 CID000151171 conivaptan Stitch 8.707E-12 1.884E-9 1.713E-8 4.334E-8 5 25
24 CID000171113 Vdavp Stitch 9.432E-12 1.956E-9 1.778E-8 4.694E-8 4 7
25 CID000024085 HgCl2 Stitch 1.100E-11 2.191E-9 1.991E-8 5.476E-8 8 263
26 CID000123960 4-Ser-8-ile-oxytocin Stitch 1.322E-11 2.530E-9 2.300E-8 6.579E-8 5 27
27 CID000123799 Mesotocin Stitch 1.943E-11 3.581E-9 3.255E-8 9.668E-8 5 29
28 CID000105077 Mcppa-avp Stitch 2.330E-11 4.142E-9 3.765E-8 1.160E-7 5 30
29 ctd:D013890 Thiourea CTD 2.777E-11 4.765E-9 4.332E-8 1.382E-7 5 31
30 CID000216237 tolvaptan Stitch 3.875E-11 6.429E-9 5.843E-8 1.929E-7 5 33
31 CID000410009 AC1L8Y60 Stitch 5.272E-11 8.464E-9 7.694E-8 2.624E-7 6 89
32 CID000119517 Dpmetyravp Stitch 8.876E-11 1.380E-8 1.255E-7 4.417E-7 4 11
33 CID000170612 Asp-pro Stitch 1.367E-10 2.062E-8 1.875E-7 6.805E-7 6 104
34 CID000006026 kinin 9 Stitch 1.435E-10 2.101E-8 1.910E-7 7.144E-7 8 363
35 CID000002611 AC1L1E2E Stitch 1.564E-10 2.224E-8 2.022E-7 7.785E-7 5 43
36 CID000172997 lixivaptan Stitch 1.921E-10 2.656E-8 2.414E-7 9.562E-7 4 13
37 CID000000827 D-arabinitol Stitch 2.392E-10 3.218E-8 2.925E-7 1.191E-6 6 114
38 CID000005772 Lypressin Stitch 2.488E-10 3.258E-8 2.962E-7 1.238E-6 5 47
39 CID000005771 Utedrin Stitch 2.688E-10 3.345E-8 3.041E-7 1.338E-6 4 14
40 CID003081047 Ovta Stitch 2.688E-10 3.345E-8 3.041E-7 1.338E-6 4 14
41 CID000005839 aldosterone Stitch 2.918E-10 3.543E-8 3.220E-7 1.452E-6 8 397
42 CID000003639 hydrochlorothiazide Stitch 3.268E-10 3.873E-8 3.520E-7 1.626E-6 6 120
43 CID000060706 Merrem Stitch 3.431E-10 3.972E-8 3.610E-7 1.708E-6 5 50
44 CID003083145 Mtpia-oxytocin Stitch 4.109E-10 4.648E-8 4.225E-7 2.045E-6 3 3
45 CID000002637 AC1L1E4K Stitch 6.169E-10 6.759E-8 6.144E-7 3.070E-6 5 56
46 CID000004377 N-methyl-DL-alanine Stitch 6.383E-10 6.759E-8 6.144E-7 3.177E-6 4 17
47 CID000068613 atosiban Stitch 6.383E-10 6.759E-8 6.144E-7 3.177E-6 4 17
48 CID013293130 CTK3D1047 Stitch 7.393E-10 7.665E-8 6.968E-7 3.679E-6 5 58
49 CID000003001 NSC9567 Stitch 8.684E-10 8.820E-8 8.017E-7 4.322E-6 6 141
50 CID000060943 SR 49059 Stitch 1.038E-9 1.017E-7 9.244E-7 5.168E-6 4 19
Show 45 more annotations

18: Disease [Display Chart] 18 input genes in category / 614 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0025281 Meniere Disease DisGeNET BeFree 2.868E-8 7.690E-6 5.382E-5 1.761E-5 4 30
2 C0032617 Polyuria DisGeNET Curated 3.290E-8 7.690E-6 5.382E-5 2.020E-5 4 31
3 C0162283 Nephrogenic Diabetes Insipidus DisGeNET Curated 3.758E-8 7.690E-6 5.382E-5 2.307E-5 4 32
4 C1563705 Nephrogenic Diabetes Insipidus, Type I DisGeNET Curated 9.626E-8 1.478E-5 1.034E-4 5.910E-5 3 9
5 C1845202 Nephrogenic Syndrome of Inappropriate Antidiuresis DisGeNET Curated 6.983E-6 7.146E-4 5.001E-3 4.287E-3 2 4
6 C0312420 Hypersexuality state DisGeNET Curated 6.983E-6 7.146E-4 5.001E-3 4.287E-3 2 4
7 C0677501 Congenital Nephrogenic Diabetes Insipidus DisGeNET BeFree 1.163E-5 1.020E-3 7.139E-3 7.141E-3 2 5
8 C0038443 Stress, Psychological DisGeNET BeFree 3.978E-5 3.053E-3 2.137E-2 2.442E-2 3 61
9 C0003469 Anxiety Disorders DisGeNET Curated 4.716E-5 3.203E-3 2.241E-2 2.896E-2 5 382
10 C0855228 Eating disorder symptom DisGeNET BeFree 5.216E-5 3.203E-3 2.241E-2 3.203E-2 2 10
11 C0023896 Alcoholic Liver Diseases DisGeNET Curated 1.000E-4 5.583E-3 3.907E-2
6.141E-2
 3 83
12 C0020488 Hypernatremia DisGeNET Curated 1.764E-4 9.027E-3
6.317E-2
1.083E-1
 2 18
13 C0011848 Diabetes Insipidus DisGeNET Curated 2.657E-4 1.220E-2
8.535E-2
1.631E-1
 2 22
14 C0085602 Polydipsia DisGeNET Curated 3.443E-4 1.220E-2
8.535E-2
2.114E-1
 2 25
15 C0154409 Recurrent major depressive episodes DisGeNET Curated 3.443E-4 1.220E-2
8.535E-2
2.114E-1
 2 25
16 C0521607 Peritoneal Fibrosis DisGeNET Curated 4.024E-4 1.220E-2
8.535E-2
2.470E-1
 2 27
17 C0003431 Antisocial Personality Disorder DisGeNET Curated 4.977E-4 1.220E-2
8.535E-2
3.056E-1
 2 30
18 C0020635 Hypopituitarism DisGeNET Curated 6.029E-4 1.220E-2
8.535E-2
3.702E-1
 2 33
19 C0687720 Central Diabetes Insipidus DisGeNET Curated 6.401E-4 1.220E-2
8.535E-2
3.930E-1
 2 34
20 C0009806 Constipation DisGeNET Curated 7.693E-4 1.220E-2
8.535E-2
4.723E-1
 3 166
21 C0020625 Hyponatremia DisGeNET Curated 8.000E-4 1.220E-2
8.535E-2
4.912E-1
 2 38
22 C0027873 Neuromyelitis Optica DisGeNET Curated 8.865E-4 1.220E-2
8.535E-2
5.443E-1
 2 40
23 C0007121 Bronchogenic Carcinoma DisGeNET BeFree 1.024E-3 1.220E-2
8.535E-2
6.289E-1
 2 43
24 C0010606 Adenoid Cystic Carcinoma DisGeNET Curated 1.069E-3 1.220E-2
8.535E-2
6.566E-1
 3 186
25 cv:C1857330 Pituitary hormone deficiency, combined 3 Clinical Variations 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
26 C0036974 Shock DisGeNET Curated 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
27 cv:C0022645 BLOOD GROUP--KIDD SYSTEM Clinical Variations 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
28 C1838359 Diffuse palmoplantar keratoderma, Bothnian type DisGeNET Curated 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
29 cv:C1843889 GIL BLOOD GROUP Clinical Variations 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
30 C1843889 GIL BLOOD GROUP DisGeNET BeFree 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
31 cv:CN176767 Cataract 15, multiple types Clinical Variations 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
32 C0021141 Inappropriate ADH Syndrome DisGeNET Curated 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
33 C3280734 FEBRILE SEIZURES, FAMILIAL, 11 DisGeNET Curated 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
34 C0023240 Legionellosis DisGeNET BeFree 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
35 C1563706 Nephrogenic Diabetes Insipidus, Type II DisGeNET Curated 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
36 cv:C1563706 Nephrogenic diabetes insipidus, autosomal Clinical Variations 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
37 OMIN:125800 DIABETES INSIPIDUS, NEPHROGENIC, AUTOSOMAL OMIM 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
38 cv:C3280730 Epilepsy, familial temporal lobe, 5 Clinical Variations 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
39 C0342394 Familial central diabetes insipidus DisGeNET BeFree 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
40 cv:C1292295 Colton Blood group system Clinical Variations 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
41 cv:C0687720 Neurohypophyseal diabetes insipidus Clinical Variations 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
42 OMIN:607457 GIL BLOOD GROUP OMIM 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
43 cv:C3280734 Febrile seizures, familial, 11 Clinical Variations 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
44 OMIN:111000 BLOOD GROUP--KIDD SYSTEM; JK OMIM 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
45 C0395005 Psychogenic polydipsia DisGeNET BeFree 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
46 C0233475 Euthymic mood DisGeNET BeFree 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
47 OMIN:110450 BLOOD GROUP--COLTON; CO OMIM 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
48 C0007780 Cerebral Embolism DisGeNET BeFree 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
49 C3280730 EPILEPSY, FAMILIAL TEMPORAL LOBE, 5 DisGeNET Curated 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
50 C3809001 CATARACT 15, MULTIPLE TYPES DisGeNET Curated 1.111E-3 1.220E-2
8.535E-2
6.820E-1
 1 1
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