Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc274_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 60 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008301 DNA binding, bending 1.051E-8 6.308E-7 2.952E-6 6.308E-7 3 20
2 GO:0097100 supercoiled DNA binding 1.071E-3 1.449E-2
6.783E-2
6.428E-2
 1 4
3 GO:0010858 calcium-dependent protein kinase regulator activity 1.071E-3 1.449E-2
6.783E-2
6.428E-2
 1 4
4 GO:0030284 estrogen receptor activity 1.339E-3 1.449E-2
6.783E-2
8.035E-2
 1 5
5 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 1.867E-3 1.449E-2
6.783E-2
1.120E-1
 2 259
6 GO:0000405 bubble DNA binding 1.874E-3 1.449E-2
6.783E-2
1.125E-1
 1 7
7 GO:0019958 C-X-C chemokine binding 1.874E-3 1.449E-2
6.783E-2
1.125E-1
 1 7
8 GO:0050786 RAGE receptor binding 3.211E-3 1.449E-2
6.783E-2
1.927E-1
 1 12
9 GO:0045295 gamma-catenin binding 3.479E-3 1.449E-2
6.783E-2
2.087E-1
 1 13
10 GO:0070016 armadillo repeat domain binding 3.479E-3 1.449E-2
6.783E-2
2.087E-1
 1 13
11 GO:0070182 DNA polymerase binding 3.479E-3 1.449E-2
6.783E-2
2.087E-1
 1 13
12 GO:0001223 transcription coactivator binding 3.479E-3 1.449E-2
6.783E-2
2.087E-1
 1 13
13 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 3.513E-3 1.449E-2
6.783E-2
2.108E-1
 2 357
14 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 3.669E-3 1.449E-2
6.783E-2
2.201E-1
 2 365
15 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 3.950E-3 1.449E-2
6.783E-2
2.370E-1
 2 379
16 GO:0000400 four-way junction DNA binding 4.280E-3 1.449E-2
6.783E-2
2.568E-1
 1 16
17 GO:0070742 C2H2 zinc finger domain binding 4.280E-3 1.449E-2
6.783E-2
2.568E-1
 1 16
18 GO:0000987 proximal promoter sequence-specific DNA binding 4.348E-3 1.449E-2
6.783E-2
2.609E-1
 2 398
19 GO:0019956 chemokine binding 5.615E-3 1.773E-2
8.298E-2
3.369E-1
 1 21
20 GO:0001530 lipopolysaccharide binding 6.148E-3 1.822E-2
8.527E-2
3.689E-1
 1 23
21 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 6.681E-3 1.822E-2
8.527E-2
4.009E-1
 1 25
22 GO:0000217 DNA secondary structure binding 6.681E-3 1.822E-2
8.527E-2
4.009E-1
 1 25
23 GO:0042056 chemoattractant activity 7.747E-3 2.003E-2
9.375E-2
4.648E-1
 1 29
24 GO:0001221 transcription cofactor binding 8.013E-3 2.003E-2
9.375E-2
4.808E-1
 1 30
25 GO:0001786 phosphatidylserine binding 8.812E-3 2.115E-2
9.897E-2
5.287E-1
 1 33
26 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1.227E-2 2.785E-2
1.303E-1
7.360E-1
 1 46
27 GO:0030331 estrogen receptor binding 1.253E-2 2.785E-2
1.303E-1
7.519E-1
 1 47
28 GO:0004869 cysteine-type endopeptidase inhibitor activity 1.545E-2 3.195E-2
1.495E-1
9.267E-1
 1 58
29 GO:0003707 steroid hormone receptor activity 1.571E-2 3.195E-2
1.495E-1
9.426E-1
 1 59
30 GO:0070491 repressing transcription factor binding 1.597E-2 3.195E-2
1.495E-1
9.585E-1
 1 60
31 GO:0003684 damaged DNA binding 1.730E-2 3.348E-2
1.567E-1
1.000E0
 1 65
32 GO:0003725 double-stranded RNA binding 1.809E-2 3.392E-2
1.587E-1
1.000E0
 1 68
33 GO:0072341 modified amino acid binding 1.967E-2 3.577E-2
1.674E-1
1.000E0
 1 74
34 GO:0030295 protein kinase activator activity 2.073E-2 3.658E-2
1.712E-1
1.000E0
 1 78
35 GO:0003727 single-stranded RNA binding 2.152E-2 3.689E-2
1.726E-1
1.000E0
 1 81
36 GO:0019209 kinase activator activity 2.283E-2 3.730E-2
1.746E-1
1.000E0
 1 86
37 GO:0008013 beta-catenin binding 2.362E-2 3.730E-2
1.746E-1
1.000E0
 1 89
38 GO:0035258 steroid hormone receptor binding 2.362E-2 3.730E-2
1.746E-1
1.000E0
 1 89
39 GO:0019955 cytokine binding 2.730E-2 3.919E-2
1.834E-1
1.000E0
 1 103
40 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 2.756E-2 3.919E-2
1.834E-1
1.000E0
 1 104
41 GO:0003697 single-stranded DNA binding 2.756E-2 3.919E-2
1.834E-1
1.000E0
 1 104
42 GO:0035326 enhancer binding 2.808E-2 3.919E-2
1.834E-1
1.000E0
 1 106
43 GO:0031072 heat shock protein binding 2.808E-2 3.919E-2
1.834E-1
1.000E0
 1 106
44 GO:0042826 histone deacetylase binding 3.018E-2 4.115E-2
1.926E-1
1.000E0
 1 114
45 GO:0016597 amino acid binding 3.279E-2 4.372E-2
2.046E-1
1.000E0
 1 124
Show 40 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 617 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0033151 V(D)J recombination 8.808E-6 3.729E-3 2.611E-2 5.435E-3 2 18
2 GO:0045063 T-helper 1 cell differentiation 1.209E-5 3.729E-3 2.611E-2 7.457E-3 2 21
3 GO:0006260 DNA replication 6.184E-5 5.690E-3 3.985E-2 3.816E-2 3 346
4 GO:0042088 T-helper 1 type immune response 6.473E-5 5.690E-3 3.985E-2 3.994E-2 2 48
5 GO:0042093 T-helper cell differentiation 7.028E-5 5.690E-3 3.985E-2 4.336E-2 2 50
6 GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 7.606E-5 5.690E-3 3.985E-2 4.693E-2 2 52
7 GO:0002293 alpha-beta T cell differentiation involved in immune response 7.904E-5 5.690E-3 3.985E-2 4.876E-2 2 53
8 GO:0002287 alpha-beta T cell activation involved in immune response 8.207E-5 5.690E-3 3.985E-2
5.064E-2
 2 54
9 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 1.014E-4 5.690E-3 3.985E-2
6.259E-2
 2 60
10 GO:0002292 T cell differentiation involved in immune response 1.014E-4 5.690E-3 3.985E-2
6.259E-2
 2 60
11 GO:0016444 somatic cell DNA recombination 1.014E-4 5.690E-3 3.985E-2
6.259E-2
 2 60
12 GO:0043367 CD4-positive, alpha-beta T cell differentiation 1.229E-4 6.317E-3 4.424E-2
7.580E-2
 2 66
13 GO:0002200 somatic diversification of immune receptors 1.343E-4 6.375E-3 4.465E-2
8.288E-2
 2 69
14 GO:0002040 sprouting angiogenesis 1.546E-4 6.707E-3 4.697E-2
9.537E-2
 2 74
15 GO:0035710 CD4-positive, alpha-beta T cell activation 1.631E-4 6.707E-3 4.697E-2
1.006E-1
 2 76
16 GO:0045639 positive regulation of myeloid cell differentiation 2.237E-4 7.530E-3
5.273E-2
1.380E-1
 2 89
17 GO:0046632 alpha-beta T cell differentiation 2.603E-4 7.530E-3
5.273E-2
1.606E-1
 2 96
18 GO:0006368 transcription elongation from RNA polymerase II promoter 2.658E-4 7.530E-3
5.273E-2
1.640E-1
 2 97
19 GO:0002286 T cell activation involved in immune response 2.658E-4 7.530E-3
5.273E-2
1.640E-1
 2 97
20 GO:2000426 negative regulation of apoptotic cell clearance 2.685E-4 7.530E-3
5.273E-2
1.657E-1
 1 1
21 GO:0002270 plasmacytoid dendritic cell activation 2.685E-4 7.530E-3
5.273E-2
1.657E-1
 1 1
22 GO:0032072 regulation of restriction endodeoxyribonuclease activity 2.685E-4 7.530E-3
5.273E-2
1.657E-1
 1 1
23 GO:0051101 regulation of DNA binding 3.356E-4 9.002E-3
6.304E-2
2.070E-1
 2 109
24 GO:0006354 DNA-templated transcription, elongation 4.411E-4 1.104E-2
7.733E-2
2.721E-1
 2 125
25 GO:0046631 alpha-beta T cell activation 5.218E-4 1.104E-2
7.733E-2
3.220E-1
 2 136
26 GO:0002840 regulation of T cell mediated immune response to tumor cell 5.369E-4 1.104E-2
7.733E-2
3.313E-1
 1 2
27 GO:0032425 positive regulation of mismatch repair 5.369E-4 1.104E-2
7.733E-2
3.313E-1
 1 2
28 GO:0002424 T cell mediated immune response to tumor cell 5.369E-4 1.104E-2
7.733E-2
3.313E-1
 1 2
29 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly 5.369E-4 1.104E-2
7.733E-2
3.313E-1
 1 2
30 GO:0097350 neutrophil clearance 5.369E-4 1.104E-2
7.733E-2
3.313E-1
 1 2
31 GO:1902107 positive regulation of leukocyte differentiation 6.858E-4 1.155E-2
8.092E-2
4.231E-1
 2 156
32 GO:0022408 negative regulation of cell-cell adhesion 6.945E-4 1.155E-2
8.092E-2
4.285E-1
 2 157
33 GO:0002285 lymphocyte activation involved in immune response 7.667E-4 1.155E-2
8.092E-2
4.731E-1
 2 165
34 GO:1901796 regulation of signal transduction by p53 class mediator 7.853E-4 1.155E-2
8.092E-2
4.845E-1
 2 167
35 GO:0071898 regulation of estrogen receptor binding 8.053E-4 1.155E-2
8.092E-2
4.969E-1
 1 3
36 GO:0071895 odontoblast differentiation 8.053E-4 1.155E-2
8.092E-2
4.969E-1
 1 3
37 GO:2000819 regulation of nucleotide-excision repair 8.053E-4 1.155E-2
8.092E-2
4.969E-1
 1 3
38 GO:0061153 trachea gland development 8.053E-4 1.155E-2
8.092E-2
4.969E-1
 1 3
39 GO:0032423 regulation of mismatch repair 8.053E-4 1.155E-2
8.092E-2
4.969E-1
 1 3
40 GO:0061152 trachea submucosa development 8.053E-4 1.155E-2
8.092E-2
4.969E-1
 1 3
41 GO:0045819 positive regulation of glycogen catabolic process 8.053E-4 1.155E-2
8.092E-2
4.969E-1
 1 3
42 GO:0035711 T-helper 1 cell activation 8.053E-4 1.155E-2
8.092E-2
4.969E-1
 1 3
43 GO:0071899 negative regulation of estrogen receptor binding 8.053E-4 1.155E-2
8.092E-2
4.969E-1
 1 3
44 GO:0006333 chromatin assembly or disassembly 9.936E-4 1.325E-2
9.278E-2
6.131E-1
 2 188
45 GO:1903708 positive regulation of hemopoiesis 1.025E-3 1.325E-2
9.278E-2
6.326E-1
 2 191
46 GO:0051106 positive regulation of DNA ligation 1.074E-3 1.325E-2
9.278E-2
6.624E-1
 1 4
47 GO:0034137 positive regulation of toll-like receptor 2 signaling pathway 1.074E-3 1.325E-2
9.278E-2
6.624E-1
 1 4
48 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway 1.074E-3 1.325E-2
9.278E-2
6.624E-1
 1 4
49 GO:0021943 formation of radial glial scaffolds 1.074E-3 1.325E-2
9.278E-2
6.624E-1
 1 4
50 GO:0006391 transcription initiation from mitochondrial promoter 1.074E-3 1.325E-2
9.278E-2
6.624E-1
 1 4
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 12 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1990907 beta-catenin-TCF complex 7.868E-4 9.441E-3 2.930E-2 9.441E-3 1 3
2 GO:0005667 transcription factor complex 3.577E-3 2.146E-2
6.660E-2
 4.292E-2 2 368
3 GO:0042645 mitochondrial nucleoid 1.201E-2 3.759E-2
1.166E-1
1.441E-1
 1 46
4 GO:0009295 nucleoid 1.253E-2 3.759E-2
1.166E-1
1.504E-1
 1 48
5 GO:0017053 transcriptional repressor complex 2.055E-2 4.714E-2
1.463E-1
2.466E-1
 1 79
6 GO:0090575 RNA polymerase II transcription factor complex 2.724E-2 4.714E-2
1.463E-1
3.269E-1
 1 105
7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 2.750E-2 4.714E-2
1.463E-1
3.300E-1
 1 106
Show 2 more annotations

4: Human Phenotype [Display Chart] 1 input genes in category / 29 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 3 input genes in category / 246 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000379 decreased hair follicle number 1.630E-4 2.376E-2
1.445E-1
 4.009E-2 2 77
2 MP:0011602 increased glutathione peroxidase activity 2.897E-4 2.376E-2
1.445E-1
7.127E-2
 1 1
3 MP:0000908 absent mesencephalic trigeminal nucleus 2.897E-4 2.376E-2
1.445E-1
7.127E-2
 1 1
4 MP:0011156 abnormal hypodermis fat layer morphology 5.320E-4 2.543E-2
1.547E-1
1.309E-1
 2 139
5 MP:0003705 abnormal hypodermis morphology 6.699E-4 2.543E-2
1.547E-1
1.648E-1
 2 156
6 MP:0000862 absent barrels in primary somatosensory cortex 8.690E-4 2.543E-2
1.547E-1
2.138E-1
 1 3
7 MP:0012582 increased peroxidase activity 8.690E-4 2.543E-2
1.547E-1
2.138E-1
 1 3
8 MP:0011601 abnormal glutathione peroxidase activity 1.159E-3 2.543E-2
1.547E-1
2.850E-1
 1 4
9 MP:0006302 abnormal ectomesenchyme morphology 1.159E-3 2.543E-2
1.547E-1
2.850E-1
 1 4
10 MP:0013400 abnormal endometrial gland development 1.448E-3 2.543E-2
1.547E-1
3.562E-1
 1 5
11 MP:0000377 abnormal hair follicle morphology 1.580E-3 2.543E-2
1.547E-1
3.888E-1
 2 240
12 MP:0001688 abnormal somite development 1.620E-3 2.543E-2
1.547E-1
3.985E-1
 2 243
13 MP:0001781 abnormal white adipose tissue amount 1.647E-3 2.543E-2
1.547E-1
4.050E-1
 2 245
14 MP:0013166 small forelimb buds 1.737E-3 2.543E-2
1.547E-1
4.274E-1
 1 6
15 MP:0013785 abnormal mammary gland bud morphology 1.737E-3 2.543E-2
1.547E-1
4.274E-1
 1 6
16 MP:0000094 absent alveolar process 1.737E-3 2.543E-2
1.547E-1
4.274E-1
 1 6
17 MP:0001677 absent apical ectodermal ridge 2.027E-3 2.543E-2
1.547E-1
4.986E-1
 1 7
18 MP:0013714 abnormal mammary gland number 2.027E-3 2.543E-2
1.547E-1
4.986E-1
 1 7
19 MP:0000629 absent mammary gland 2.027E-3 2.543E-2
1.547E-1
4.986E-1
 1 7
20 MP:0000809 absent hippocampus 2.316E-3 2.543E-2
1.547E-1
5.698E-1
 1 8
21 MP:0012579 abnormal peroxidase activity 2.316E-3 2.543E-2
1.547E-1
5.698E-1
 1 8
22 MP:0003931 absent molars 2.316E-3 2.543E-2
1.547E-1
5.698E-1
 1 8
23 MP:0030572 abnormal pilosebaceous unit morphology 2.429E-3 2.543E-2
1.547E-1
5.976E-1
 2 298
24 MP:0000906 abnormal trigeminal V mesencephalic nucleus morphology 2.605E-3 2.543E-2
1.547E-1
6.409E-1
 1 9
25 MP:0002073 abnormal hair growth 2.729E-3 2.543E-2
1.547E-1
6.713E-1
 2 316
26 MP:0002970 abnormal white adipose tissue morphology 2.746E-3 2.543E-2
1.547E-1
6.755E-1
 2 317
27 MP:0004790 absent upper incisors 2.895E-3 2.543E-2
1.547E-1
7.121E-1
 1 10
28 MP:0009097 absent endometrial glands 2.895E-3 2.543E-2
1.547E-1
7.121E-1
 1 10
29 MP:0000118 arrest of tooth development 3.184E-3 2.571E-2
1.564E-1
7.832E-1
 1 11
30 MP:0009174 absent pancreatic beta cells 3.184E-3 2.571E-2
1.564E-1
7.832E-1
 1 11
31 MP:0004135 abnormal mammary gland embryonic development 3.473E-3 2.571E-2
1.564E-1
8.543E-1
 1 12
32 MP:0004791 absent lower incisors 3.473E-3 2.571E-2
1.564E-1
8.543E-1
 1 12
33 MP:0000648 absent sebaceous gland 3.473E-3 2.571E-2
1.564E-1
8.543E-1
 1 12
34 MP:0013164 abnormal forelimb bud morphology 3.762E-3 2.571E-2
1.564E-1
9.254E-1
 1 13
35 MP:0000448 pointed snout 3.762E-3 2.571E-2
1.564E-1
9.254E-1
 1 13
36 MP:0000394 absent hair follicle melanin granules 3.762E-3 2.571E-2
1.564E-1
9.254E-1
 1 13
37 MP:0000814 absent dentate gyrus 4.340E-3 2.749E-2
1.673E-1
1.000E0
 1 15
38 MP:0008859 abnormal hair cycle catagen phase 4.340E-3 2.749E-2
1.673E-1
1.000E0
 1 15
39 MP:0008051 abnormal memory T cell physiology 4.629E-3 2.749E-2
1.673E-1
1.000E0
 1 16
40 MP:0011636 disorganized mitochondrial cristae 4.629E-3 2.749E-2
1.673E-1
1.000E0
 1 16
41 MP:0006400 decreased molar number 4.629E-3 2.749E-2
1.673E-1
1.000E0
 1 16
42 MP:0030610 absent teeth 4.918E-3 2.749E-2
1.673E-1
1.000E0
 1 17
43 MP:0003989 abnormal barrel cortex morphology 4.918E-3 2.749E-2
1.673E-1
1.000E0
 1 17
44 MP:0004191 neuronal intranuclear inclusions 4.918E-3 2.749E-2
1.673E-1
1.000E0
 1 17
45 MP:0000860 abnormal primary somatosensory cortex morphology 5.495E-3 2.846E-2
1.731E-1
1.000E0
 1 19
46 MP:0004575 small limb buds 5.784E-3 2.846E-2
1.731E-1
1.000E0
 1 20
47 MP:0009004 progressive hair loss 5.784E-3 2.846E-2
1.731E-1
1.000E0
 1 20
48 MP:0008843 absent subcutaneous adipose tissue 5.784E-3 2.846E-2
1.731E-1
1.000E0
 1 20
49 MP:0004143 muscle hypertonia 5.784E-3 2.846E-2
1.731E-1
1.000E0
 1 20
50 MP:0000936 small embryonic telencephalon 5.784E-3 2.846E-2
1.731E-1
1.000E0
 1 20
Show 45 more annotations

6: Domain [Display Chart] 5 input genes in category / 36 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00505 HMG box Pfam 2.847E-10 2.984E-9 1.246E-8 1.025E-8 4 53
2 SM00398 HMG SMART 3.075E-10 2.984E-9 1.246E-8 1.107E-8 4 54
3 PS50118 HMG BOX 2 PROSITE 3.075E-10 2.984E-9 1.246E-8 1.107E-8 4 54
4 1.10.30.10 - Gene3D 3.316E-10 2.984E-9 1.246E-8 1.194E-8 4 55
5 IPR009071 HMG box dom InterPro 6.579E-10 4.737E-9 1.978E-8 2.369E-8 4 65
6 PF08512 Rtt106 Pfam 5.698E-8 2.564E-7 1.070E-6 2.051E-6 2 2
7 SM01287 Rtt106 SMART 5.698E-8 2.564E-7 1.070E-6 2.051E-6 2 2
8 IPR013719 DUF1747 InterPro 5.698E-8 2.564E-7 1.070E-6 2.051E-6 2 2
9 PF09011 HMG box 2 Pfam 2.050E-6 8.199E-6 3.423E-5 7.379E-5 2 9
10 PF03531 SSrecog Pfam 2.669E-4 5.057E-4 2.111E-3 9.608E-3 1 1
11 PF14826 FACT-Spt16 Nlob Pfam 2.669E-4 5.057E-4 2.111E-3 9.608E-3 1 1
12 IPR033825 SPT16 InterPro 2.669E-4 5.057E-4 2.111E-3 9.608E-3 1 1
13 IPR024954 SSRP1 dom InterPro 2.669E-4 5.057E-4 2.111E-3 9.608E-3 1 1
14 SM01285 FACT-Spt16 Nlob SMART 2.669E-4 5.057E-4 2.111E-3 9.608E-3 1 1
15 IPR000969 SSrcognition InterPro 2.669E-4 5.057E-4 2.111E-3 9.608E-3 1 1
16 IPR013953 FACT Spt16p InterPro 2.669E-4 5.057E-4 2.111E-3 9.608E-3 1 1
17 PF08644 SPT16 Pfam 2.669E-4 5.057E-4 2.111E-3 9.608E-3 1 1
18 IPR029148 FACT-Spt16 Nlobe InterPro 2.669E-4 5.057E-4 2.111E-3 9.608E-3 1 1
19 SM01286 SPT16 SMART 2.669E-4 5.057E-4 2.111E-3 9.608E-3 1 1
20 IPR017967 HMG boxA CS InterPro 8.005E-4 1.441E-3 6.015E-3 2.882E-2 1 3
21 IPR013558 CTNNB1-bd N InterPro 1.067E-3 1.670E-3 6.973E-3 3.842E-2 1 4
22 IPR024940 TCF/LEF InterPro 1.067E-3 1.670E-3 6.973E-3 3.842E-2 1 4
23 PF08347 CTNNB1 binding Pfam 1.067E-3 1.670E-3 6.973E-3 3.842E-2 1 4
24 IPR029149 Creatin/AminoP/Spt16 NTD InterPro 1.334E-3 1.921E-3 8.018E-3 4.802E-2 1 5
25 3.40.350.10 - Gene3D 1.334E-3 1.921E-3 8.018E-3 4.802E-2 1 5
26 3.30.70.240 - Gene3D 1.867E-3 2.489E-3 1.039E-2
6.721E-2
 1 7
27 IPR000640 EFG V InterPro 1.867E-3 2.489E-3 1.039E-2
6.721E-2
 1 7
28 3.90.230.10 - Gene3D 2.400E-3 2.880E-3 1.202E-2
8.640E-2
 1 9
29 PF00557 Peptidase M24 Pfam 2.400E-3 2.880E-3 1.202E-2
8.640E-2
 1 9
30 IPR000994 Pept M24 InterPro 2.400E-3 2.880E-3 1.202E-2
8.640E-2
 1 9
31 PS00353 HMG BOX 1 PROSITE 2.666E-3 3.096E-3 1.293E-2
9.598E-2
 1 10
32 4.10.900.10 - Gene3D 7.716E-3 8.418E-3 3.514E-2
2.778E-1
 1 29
33 IPR027397 Catenin binding dom InterPro 7.716E-3 8.418E-3 3.514E-2
2.778E-1
 1 29
Show 28 more annotations

7: Pathway [Display Chart] 5 input genes in category / 99 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269082 Tat-mediated HIV elongation arrest and recovery BioSystems: REACTOME 1.000E-4 2.266E-3 1.173E-2 9.904E-3 2 40
2 1269083 Pausing and recovery of Tat-mediated HIV elongation BioSystems: REACTOME 1.000E-4 2.266E-3 1.173E-2 9.904E-3 2 40
3 1269079 HIV elongation arrest and recovery BioSystems: REACTOME 1.104E-4 2.266E-3 1.173E-2 1.093E-2 2 42
4 1269081 Pausing and recovery of HIV elongation BioSystems: REACTOME 1.104E-4 2.266E-3 1.173E-2 1.093E-2 2 42
5 1269076 Tat-mediated elongation of the HIV-1 transcript BioSystems: REACTOME 1.697E-4 2.266E-3 1.173E-2 1.680E-2 2 52
6 1269074 HIV Transcription Elongation BioSystems: REACTOME 1.697E-4 2.266E-3 1.173E-2 1.680E-2 2 52
7 1269077 Formation of HIV-1 elongation complex containing HIV-1 Tat BioSystems: REACTOME 1.697E-4 2.266E-3 1.173E-2 1.680E-2 2 52
8 1269080 Formation of HIV elongation complex in the absence of HIV Tat BioSystems: REACTOME 1.831E-4 2.266E-3 1.173E-2 1.813E-2 2 54
9 1269682 RNA Polymerase II Transcription Elongation BioSystems: REACTOME 2.823E-4 2.795E-3 1.447E-2 2.795E-2 2 67
10 1269684 Formation of RNA Pol II elongation complex BioSystems: REACTOME 2.823E-4 2.795E-3 1.447E-2 2.795E-2 2 67
11 1383075 TP53 Regulates Transcription of DNA Repair Genes BioSystems: REACTOME 3.261E-4 2.935E-3 1.520E-2 3.229E-2 2 72
12 1269070 Transcription of the HIV genome BioSystems: REACTOME 3.927E-4 3.240E-3 1.677E-2 3.888E-2 2 79
13 1269676 RNA Polymerase II Pre-transcription Events BioSystems: REACTOME 5.095E-4 3.847E-3 1.992E-2
5.044E-2
 2 90
14 1383080 Regulation of TP53 Activity through Phosphorylation BioSystems: REACTOME 5.440E-4 3.847E-3 1.992E-2
5.386E-2
 2 93
15 1269673 Mitochondrial transcription initiation BioSystems: REACTOME 1.204E-3 7.706E-3 3.990E-2
1.192E-1
 1 3
16 1269069 Late Phase of HIV Life Cycle BioSystems: REACTOME 1.245E-3 7.706E-3 3.990E-2
1.233E-1
 2 141
17 1269058 HIV Life Cycle BioSystems: REACTOME 1.483E-3 8.118E-3 4.203E-2
1.469E-1
 2 154
18 1269672 Transcription from mitochondrial promoters BioSystems: REACTOME 1.606E-3 8.118E-3 4.203E-2
1.590E-1
 1 4
19 1269675 RNA Polymerase II Transcription BioSystems: REACTOME 1.640E-3 8.118E-3 4.203E-2
1.624E-1
 2 162
20 1383076 Regulation of TP53 Activity BioSystems: REACTOME 1.640E-3 8.118E-3 4.203E-2
1.624E-1
 2 162
21 1269603 Binding of TCF/LEF:CTNNB1 to target gene promoters BioSystems: REACTOME 2.809E-3 1.324E-2
6.855E-2
2.780E-1
 1 7
22 1269057 HIV Infection BioSystems: REACTOME 3.561E-3 1.603E-2
8.297E-2
3.526E-1
 2 240
23 M7239 Apoptotic DNA fragmentation and tissue homeostasis MSigDB C2 BIOCARTA (v6.0) 4.010E-3 1.726E-2
8.937E-2
3.970E-1
 1 10
24 1269598 Repression of WNT target genes BioSystems: REACTOME 4.811E-3 1.842E-2
9.539E-2
4.763E-1
 1 12
25 1269276 DEx/H-box helicases activate type I IFN and inflammatory cytokines production BioSystems: REACTOME 5.211E-3 1.842E-2
9.539E-2
5.159E-1
 1 13
26 1270293 Activation of DNA fragmentation factor BioSystems: REACTOME 5.211E-3 1.842E-2
9.539E-2
5.159E-1
 1 13
27 1269258 Advanced glycosylation endproduct receptor signaling BioSystems: REACTOME 5.211E-3 1.842E-2
9.539E-2
5.159E-1
 1 13
28 1270292 Apoptosis induced DNA fragmentation BioSystems: REACTOME 5.211E-3 1.842E-2
9.539E-2
5.159E-1
 1 13
29 M8516 Multi-step Regulation of Transcription by Pitx2 MSigDB C2 BIOCARTA (v6.0) 6.011E-3 2.052E-2
1.062E-1
5.950E-1
 1 15
30 1427857 Regulation of TLR by endogenous ligand BioSystems: REACTOME 6.410E-3 2.115E-2
1.095E-1
6.346E-1
 1 16
31 1269271 RIP-mediated NFkB activation via ZBP1 BioSystems: REACTOME 8.407E-3 2.622E-2
1.357E-1
8.323E-1
 1 21
32 1269654 Transcriptional Regulation by TP53 BioSystems: REACTOME 8.475E-3 2.622E-2
1.357E-1
8.390E-1
 2 374
33 1269056 Infectious disease BioSystems: REACTOME 9.330E-3 2.783E-2
1.441E-1
9.237E-1
 2 393
34 1269269 ZBP1(DAI) mediated induction of type I IFNs BioSystems: REACTOME 1.000E-2 2.783E-2
1.441E-1
9.902E-1
 1 25
35 1269263 TRAF6 mediated NF-kB activation BioSystems: REACTOME 1.000E-2 2.783E-2
1.441E-1
9.902E-1
 1 25
36 PW:0000662 mismatch repair pathway Pathway Ontology 1.040E-2 2.783E-2
1.441E-1
1.000E0
 1 26
37 M16517 WNT Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.040E-2 2.783E-2
1.441E-1
1.000E0
 1 26
38 M11106 Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages MSigDB C2 BIOCARTA (v6.0) 1.080E-2 2.813E-2
1.457E-1
1.000E0
 1 27
39 83112 Thyroid cancer BioSystems: KEGG 1.159E-2 2.870E-2
1.486E-1
1.000E0
 1 29
40 1269210 TAK1 activates NFkB by phosphorylation and activation of IKKs complex BioSystems: REACTOME 1.159E-2 2.870E-2
1.486E-1
1.000E0
 1 29
41 83043 Base excision repair BioSystems: KEGG 1.319E-2 3.184E-2
1.648E-1
1.000E0
 1 33
42 1269604 Deactivation of the beta-catenin transactivating complex BioSystems: REACTOME 1.715E-2 4.043E-2
2.093E-1
1.000E0
 1 43
43 1268841 Transcriptional activation of mitochondrial biogenesis BioSystems: REACTOME 1.794E-2 4.127E-2
2.137E-1
1.000E0
 1 45
44 PW:0000201 canonical Wnt signaling Pathway Ontology 1.834E-2 4.127E-2
2.137E-1
1.000E0
 1 46
45 137945 amb2 Integrin signaling BioSystems: Pathway Interaction Database 1.913E-2 4.209E-2
2.179E-1
1.000E0
 1 48
46 83109 Endometrial cancer BioSystems: KEGG 1.992E-2 4.288E-2
2.220E-1
1.000E0
 1 50
47 1270287 Apoptotic execution phase BioSystems: REACTOME 2.111E-2 4.336E-2
2.245E-1
1.000E0
 1 53
48 1268839 Mitochondrial biogenesis BioSystems: REACTOME 2.150E-2 4.336E-2
2.245E-1
1.000E0
 1 54
49 83113 Basal cell carcinoma BioSystems: KEGG 2.190E-2 4.336E-2
2.245E-1
1.000E0
 1 55
50 83117 Acute myeloid leukemia BioSystems: KEGG 2.190E-2 4.336E-2
2.245E-1
1.000E0
 1 55
Show 45 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 1986 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17403666 Isolation and characterization of proteins associated with histone H3 tails in vivo. Pubmed 4.368E-9 4.538E-6 3.708E-5 8.675E-6 3 30
2 23839038 Complex mutual regulation of facilitates chromatin transcription (FACT) subunits on both mRNA and protein levels in human cells. Pubmed 1.371E-8 4.538E-6 3.708E-5 2.723E-5 2 2
3 26378236 FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency. Pubmed 1.371E-8 4.538E-6 3.708E-5 2.723E-5 2 2
4 9489704 FACT, a factor that facilitates transcript elongation through nucleosomes. Pubmed 1.371E-8 4.538E-6 3.708E-5 2.723E-5 2 2
5 17209051 Human SSRP1 has Spt16-dependent and -independent roles in gene transcription. Pubmed 1.371E-8 4.538E-6 3.708E-5 2.723E-5 2 2
6 12934006 FACT facilitates transcription-dependent nucleosome alteration. Pubmed 1.371E-8 4.538E-6 3.708E-5 2.723E-5 2 2
7 14660563 Nek9, a novel FACT-associated protein, modulates interphase progression. Pubmed 4.113E-8 8.169E-6 6.675E-5 8.169E-5 2 3
8 16682447 Modulation of nucleosome-binding activity of FACT by poly(ADP-ribosyl)ation. Pubmed 4.113E-8 8.169E-6 6.675E-5 8.169E-5 2 3
9 26842758 Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability. Pubmed 4.113E-8 8.169E-6 6.675E-5 8.169E-5 2 3
10 10421373 The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. Pubmed 4.113E-8 8.169E-6 6.675E-5 8.169E-5 2 3
11 9836642 Requirement of RSF and FACT for transcription of chromatin templates in vitro. Pubmed 8.226E-8 1.361E-5 1.112E-4 1.634E-4 2 4
12 24357716 Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20. Pubmed 8.226E-8 1.361E-5 1.112E-4 1.634E-4 2 4
13 10912001 FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. Pubmed 1.371E-7 1.945E-5 1.589E-4 2.723E-4 2 5
14 18036521 Modulation of SRF-dependent gene expression by association of SPT16 with MKL1. Pubmed 1.371E-7 1.945E-5 1.589E-4 2.723E-4 2 5
15 12393879 p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. Pubmed 2.879E-7 3.573E-5 2.920E-4 5.717E-4 2 7
16 11239457 A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Pubmed 2.879E-7 3.573E-5 2.920E-4 5.717E-4 2 7
17 20599239 Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription. Pubmed 3.838E-7 4.484E-5 3.664E-4 7.622E-4 2 8
18 21055985 A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Pubmed 6.167E-7 6.447E-5 5.268E-4 1.225E-3 2 10
19 16902406 Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication. Pubmed 6.167E-7 6.447E-5 5.268E-4 1.225E-3 2 10
20 18406329 FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Pubmed 7.538E-7 7.485E-5 6.116E-4 1.497E-3 2 11
21 21679440 Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin. Pubmed 9.045E-7 8.491E-5 6.938E-4 1.796E-3 2 12
22 27637333 Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells. Pubmed 9.886E-7 8.491E-5 6.938E-4 1.963E-3 3 178
23 27647897 BMI1-UBR5 axis regulates transcriptional repression at damaged chromatin. Pubmed 1.069E-6 8.491E-5 6.938E-4 2.123E-3 2 13
24 19214185 FACT facilitates chromatin transcription by RNA polymerases I and III. Pubmed 1.069E-6 8.491E-5 6.938E-4 2.123E-3 2 13
25 19836239 UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA. Pubmed 1.069E-6 8.491E-5 6.938E-4 2.123E-3 2 13
26 15616580 Histone modifications defining active genes persist after transcriptional and mitotic inactivation. Pubmed 1.247E-6 9.525E-5 7.783E-4 2.476E-3 2 14
27 20603019 TIF1gamma controls erythroid cell fate by regulating transcription elongation. Pubmed 2.096E-6 1.542E-4 1.260E-3 4.163E-3 2 18
28 23329831 Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. Pubmed 2.343E-6 1.604E-4 1.311E-3 4.652E-3 2 19
29 16522924 The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca(2+)/calmodulin in the ionizing radiation-induced cell cycle arrest. Pubmed 2.343E-6 1.604E-4 1.311E-3 4.652E-3 2 19
30 20932939 Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Pubmed 2.520E-6 1.668E-4 1.363E-3 5.005E-3 3 243
31 28077445 Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation. Pubmed 2.778E-6 1.779E-4 1.454E-3 5.516E-3 3 251
32 21113133 RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells. Pubmed 2.876E-6 1.785E-4 1.459E-3 5.713E-3 2 21
33 16713563 Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Pubmed 3.164E-6 1.904E-4 1.556E-3 6.284E-3 2 22
34 15385968 Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. Pubmed 4.108E-6 2.400E-4 1.961E-3 8.159E-3 2 25
35 25817432 Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. Pubmed 6.366E-6 3.304E-4 2.700E-3 1.264E-2 2 31
36 12676794 The RNA polymerase II elongation complex. Pubmed 7.228E-6 3.304E-4 2.700E-3 1.435E-2 2 33
37 29089422 A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation. Pubmed 8.623E-6 3.304E-4 2.700E-3 1.712E-2 2 36
38 16622419 The human CENP-A centromeric nucleosome-associated complex. Pubmed 8.623E-6 3.304E-4 2.700E-3 1.712E-2 2 36
39 23182705 Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity. Pubmed 1.813E-5 3.304E-4 2.700E-3 3.601E-2 2 52
40 14559993 Regulation of alternative splicing by SRrp86 and its interacting proteins. Pubmed 2.182E-5 3.304E-4 2.700E-3 4.333E-2 2 57
41 20362542 An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pubmed 5.589E-5 3.304E-4 2.700E-3
1.110E-1
 2 91
42 19394292 Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. Pubmed 7.589E-5 3.304E-4 2.700E-3
1.507E-1
 2 106
43 21549307 Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Pubmed 9.091E-5 3.304E-4 2.700E-3
1.805E-1
 2 116
44 21589869 RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Pubmed 1.160E-4 3.304E-4 2.700E-3
2.303E-1
 2 131
45 26350087 Effects of HMGB1 on proliferation and apoptosis of human brain glioma CD133 cells. Pubmed 1.309E-4 3.304E-4 2.700E-3
2.600E-1
 1 1
46 25602579 Preliminary study of high mobility group box chromosomal protein 1(HMGB1) in ankylosing spondylitis patients. Pubmed 1.309E-4 3.304E-4 2.700E-3
2.600E-1
 1 1
47 18277058 Elevation of high-mobility group box 1 concentration in asphyxiated neonates. Pubmed 1.309E-4 3.304E-4 2.700E-3
2.600E-1
 1 1
48 22884669 Elevated serum levels of high mobility group box 1 (HMGB1) protein in dengue-infected patients are associated with disease symptoms and secondary infection. Pubmed 1.309E-4 3.304E-4 2.700E-3
2.600E-1
 1 1
49 23148224 High mobility group Box 1 inhibits human pulmonary artery endothelial cell migration via a Toll-like receptor 4- and interferon response factor 3-dependent mechanism(s). Pubmed 1.309E-4 3.304E-4 2.700E-3
2.600E-1
 1 1
50 16120831 An internal ribosome entry site mediates translation of lymphoid enhancer factor-1. Pubmed 1.309E-4 3.304E-4 2.700E-3
2.600E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 367 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:HMGB2 HMGB2 interactions 3.856E-10 1.415E-7 9.177E-7 1.415E-7 4 54
2 int:WDR76 WDR76 interactions 2.825E-7 5.184E-5 3.361E-4 1.037E-4 3 55
3 int:XPC XPC interactions 6.970E-7 8.526E-5 5.528E-4 2.558E-4 3 74
4 int:HMGB1 HMGB1 interactions 3.401E-6 3.121E-4 2.024E-3 1.248E-3 3 125
5 int:SSRP1 SSRP1 interactions 5.656E-6 4.093E-4 2.654E-3 2.076E-3 3 148
6 int:RPA4 RPA4 interactions 6.691E-6 4.093E-4 2.654E-3 2.456E-3 2 15
7 int:SUPT16H SUPT16H interactions 8.279E-6 4.148E-4 2.689E-3 3.038E-3 3 168
8 int:H3F3A H3F3A interactions 9.041E-6 4.148E-4 2.689E-3 3.318E-3 3 173
9 int:NFATC2 NFATC2 interactions 1.198E-5 4.885E-4 3.167E-3 4.396E-3 3 190
10 int:SUMO2 SUMO2 interactions 1.711E-5 5.374E-4 3.484E-3 6.280E-3 3 214
11 int:SPIN2B SPIN2B interactions 1.757E-5 5.374E-4 3.484E-3 6.448E-3 2 24
12 int:TLE2 TLE2 interactions 1.757E-5 5.374E-4 3.484E-3 6.448E-3 2 24
13 int:NAA40 NAA40 interactions 1.910E-5 5.391E-4 3.496E-3 7.008E-3 2 25
14 int:MMS22L MMS22L interactions 2.234E-5 5.856E-4 3.797E-3 8.198E-3 2 27
15 int:MRTFA MRTFA interactions 2.405E-5 5.885E-4 3.816E-3 8.828E-3 2 28
16 int:HMGB3 HMGB3 interactions 2.767E-5 6.348E-4 4.116E-3 1.016E-2 2 30
17 int:PYHIN1 PYHIN1 interactions 3.317E-5 6.846E-4 4.439E-3 1.218E-2 3 267
18 int:MACROD1 MACROD1 interactions 3.358E-5 6.846E-4 4.439E-3 1.232E-2 2 33
19 int:TONSL TONSL interactions 4.005E-5 7.119E-4 4.616E-3 1.470E-2 2 36
20 int:APLF APLF interactions 4.005E-5 7.119E-4 4.616E-3 1.470E-2 2 36
21 int:PARP1 PARP1 interactions 4.074E-5 7.119E-4 4.616E-3 1.495E-2 3 286
22 int:NEK9 NEK9 interactions 4.709E-5 7.856E-4 5.094E-3 1.728E-2 2 39
23 int:POLB POLB interactions 5.470E-5 8.728E-4 5.659E-3 2.008E-2 2 42
24 int:SPIN1 SPIN1 interactions 6.864E-5 1.008E-3 6.533E-3 2.519E-2 2 47
25 int:POLL POLL interactions 6.864E-5 1.008E-3 6.533E-3 2.519E-2 2 47
26 int:HES1 HES1 interactions 9.079E-5 1.282E-3 8.310E-3 3.332E-2 2 54
27 int:PHIP PHIP interactions 1.012E-4 1.327E-3 8.602E-3 3.715E-2 2 57
28 int:RNF146 RNF146 interactions 1.012E-4 1.327E-3 8.602E-3 3.715E-2 2 57
29 int:HNF1A HNF1A interactions 1.048E-4 1.327E-3 8.602E-3 3.847E-2 2 58
30 int:RTF1 RTF1 interactions 1.199E-4 1.466E-3 9.508E-3 4.399E-2 2 62
31 int:PAF1 PAF1 interactions 1.401E-4 1.605E-3 1.041E-2
5.141E-2
 2 67
32 int:PNKP PNKP interactions 1.401E-4 1.605E-3 1.041E-2
5.141E-2
 2 67
33 int:FMNL1 FMNL1 interactions 1.443E-4 1.605E-3 1.041E-2
5.296E-2
 2 68
34 int:CHD1L CHD1L interactions 1.529E-4 1.651E-3 1.070E-2
5.613E-2
 2 70
35 int:FYTTD1 FYTTD1 interactions 1.710E-4 1.793E-3 1.162E-2
6.275E-2
 2 74
36 int:ATRX ATRX interactions 1.852E-4 1.888E-3 1.224E-2
6.795E-2
 2 77
37 int:CEP164 CEP164 interactions 2.257E-4 2.170E-3 1.407E-2
8.284E-2
 2 85
38 int:TRIM33 TRIM33 interactions 2.311E-4 2.170E-3 1.407E-2
8.480E-2
 2 86
39 int:SREK1 SREK1 interactions 2.365E-4 2.170E-3 1.407E-2
8.678E-2
 2 87
40 int:AGTRAP AGTRAP interactions 2.365E-4 2.170E-3 1.407E-2
8.678E-2
 2 87
41 int:CENPA CENPA interactions 2.587E-4 2.316E-3 1.502E-2
9.495E-2
 2 91
42 int:POLR1A POLR1A interactions 2.879E-4 2.516E-3 1.631E-2
1.057E-1
 2 96
43 int:HIST1H2BA HIST1H2BA interactions 3.001E-4 2.561E-3 1.661E-2
1.101E-1
 2 98
44 int:H2AFY2 H2AFY2 interactions 3.379E-4 2.809E-3 1.821E-2
1.240E-1
 2 104
45 int:S100A9 S100A9 interactions 3.444E-4 2.809E-3 1.821E-2
1.264E-1
 2 105
46 int:TLE1 TLE1 interactions 4.275E-4 3.338E-3 2.164E-2
1.569E-1
 2 117
47 int:CTR9 CTR9 interactions 4.275E-4 3.338E-3 2.164E-2
1.569E-1
 2 117
48 int:CDC14B CDC14B interactions 4.422E-4 3.381E-3 2.192E-2
1.623E-1
 2 119
49 int:CNTROB CNTROB interactions 4.723E-4 3.538E-3 2.294E-2
1.733E-1
 2 123
50 int:SAP18 SAP18 interactions 4.878E-4 3.580E-3 2.321E-2
1.790E-1
 2 125
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 4q23-q25 4q23-q25 2.885E-4 1.442E-3 3.294E-3 1.442E-3 1 2
2 10q21 10q21 2.450E-3 4.322E-3 9.868E-3 1.225E-2 1 17
3 11q12 11q12 3.026E-3 4.322E-3 9.868E-3 1.513E-2 1 21
4 13q12 13q12 3.458E-3 4.322E-3 9.868E-3 1.729E-2 1 24
5 14q11.2 14q11.2 2.683E-2 2.683E-2
6.126E-2
1.341E-1
 1 188

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 78 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 1 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 511 Canonical high mobility group genenames.org 6.046E-4 6.046E-4 6.046E-4 6.046E-4 1 11

13: Coexpression [Display Chart] 5 input genes in category / 685 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M7580 Genes down-regulated in CD11b Spleen from BALBc mouse versus CD11b Tumor from BALBc mouse. MSigDB C7: Immunologic Signatures (v6.0) 6.004E-6 3.272E-3 2.326E-2 4.112E-3 3 197
2 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.555E-6 3.272E-3 2.326E-2 6.545E-3 3 230
3 M6509 Genes in a cCDNA library from hematopoietic stem cells (HSC) after subtraction of lineage-specific markers. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.522E-5 6.567E-3 4.667E-2 2.412E-2 2 44
4 15260889-TableS2a Human Breast Dairkee04 479genes GeneSigDB 3.835E-5 6.567E-3 4.667E-2 2.627E-2 3 366
5 16357169-SuppTable4 Human Prostate Floryk05 68genes GeneSigDB 6.146E-5 8.420E-3
5.985E-2
 4.210E-2 2 58
6 18535662-TableS2b Mouse Lymphoma Wu08 1016genes GeneSigDB 7.579E-5 8.653E-3
6.150E-2
5.192E-2
 3 460
7 20067540-Table3 Human UmbilicalCordBloodCells Miyagawa09 145genes GeneSigDB 3.592E-4 2.298E-2
1.634E-1
2.461E-1
 2 140
8 M6685 Genes down-regulated in ndothelial cells: untreated versus interferon alpha. MSigDB C7: Immunologic Signatures (v6.0) 4.865E-4 2.298E-2
1.634E-1
3.332E-1
 2 163
9 16239301-SuppTable2a Human Breast Harvell 194genes GeneSigDB 5.732E-4 2.298E-2
1.634E-1
3.926E-1
 2 177
10 15208663-SuppTable1a Human Colon Kim04 285genes GeneSigDB 6.950E-4 2.298E-2
1.634E-1
4.761E-1
 2 195
11 M3166 Genes up-regulated in comparison of germinal center B cells versus plasma cells. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.298E-2
1.634E-1
4.957E-1
 2 199
12 M7056 Genes up-regulated in hematopoietic stem cells versus pro-B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.298E-2
1.634E-1
5.006E-1
 2 200
13 M7900 Genes down-regulated in monocytes (12h) versus macrophages (12h) treated with IL4 [GeneID=3565] and rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.298E-2
1.634E-1
5.006E-1
 2 200
14 M5181 Genes up-regulated in comparison of dendritic cells exposed to L. major versus macrophages exposed to L. major. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.298E-2
1.634E-1
5.006E-1
 2 200
15 M9033 Genes up-regulated in macrophages with knockout of HDAC3 [GeneID=8841]: untreated versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.298E-2
1.634E-1
5.006E-1
 2 200
16 M7884 Genes down-regulated in B cells: light zone versus naïve. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.298E-2
1.634E-1
5.006E-1
 2 200
17 M7408 Genes down-regulated in neuron cell line infected with western equine encephalitis virus: immature versus mature cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.298E-2
1.634E-1
5.006E-1
 2 200
18 M7908 Genes up-regulated in wildtype bone marrow-derived macrophages: control versus IL4 [GeneID=3565] and rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.298E-2
1.634E-1
5.006E-1
 2 200
19 M4664 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells versus CD4 [GeneID=920] T cells treated with leukocyte costimulatory blockade antibodies. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.298E-2
1.634E-1
5.006E-1
 2 200
20 M4497 Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus unstimulated neutrophils. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.298E-2
1.634E-1
5.006E-1
 2 200
21 M4601 Genes up-regulated in comparison of CD25+ T cells treated with IL4 [GeneID=3565] versus CD25- T cells treated with IL4 [GeneID=3565] at day 5. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.298E-2
1.634E-1
5.006E-1
 2 200
22 M9695 Genes up-regulated in DLBCL (diffuse large B-cell lymphoma) cell lines sensitive to stimulation of CD40 [GeneID=958] relative to the resistant ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.381E-4 2.298E-2
1.634E-1
5.056E-1
 2 201
23 M18938 Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of both HDAC1 and HDAC2 [GeneID=3065;3066] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.032E-3 3.071E-2
2.182E-1
7.072E-1
 2 238
24 M2128 Genes up-regulated in growing IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.076E-3 3.071E-2
2.182E-1
7.370E-1
 2 243
25 M16740 Up-regulated genes in both rectal and colon carcinoma compared to normal mucosa samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.475E-3 3.983E-2
2.831E-1
1.000E0
 2 285
26 19138562-Table5 Human Leukemia DenBoer09 10genes GeneSigDB 1.512E-3 3.983E-2
2.831E-1
1.000E0
 1 7
27 M1791 Epithelial and mesenchymal markers down-regulated in MEF cells (embryonic fibroblasts) after knockout of PRKAR1A [GeneID=5573]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.728E-3 4.383E-2
3.115E-1
1.000E0
 1 8
28 16397240-Table1d Human Colon Grade06 12genes WntSignaling GeneSigDB 1.944E-3 4.629E-2
3.290E-1
1.000E0
 1 9
29 17150101-TableS1l Human Breast Troester06 436genes-up-DOX-ZR75-1 GeneSigDB 1.960E-3 4.629E-2
3.290E-1
1.000E0
 2 329
30 M17096 Genes exclusively up-regulated in B lymphocytes from WM (Waldenstroem's macroglobulinemia) but with a similar expression profile in MM (macroglobulinemia) and normal cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.806E-3 4.826E-2
3.430E-1
1.000E0
 1 13
31 18922970-Table1a Human Breast Moon08 20genes C1 GeneSigDB 2.806E-3 4.826E-2
3.430E-1
1.000E0
 1 13
32 20201062-Table2 Mouse EmbryonicStemCell Maruotti10 25genes GeneSigDB 3.022E-3 4.826E-2
3.430E-1
1.000E0
 1 14
33 M9516 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.215E-3 4.826E-2
3.430E-1
1.000E0
 2 423
34 17273163-Supp1b Human Skin Micke07 16genes GeneSigDB 3.238E-3 4.826E-2
3.430E-1
1.000E0
 1 15
35 M12027 Genes up-regulated in HCT8/S11 cells (colon cancer) engineered to stably express NTN1 [GeneID=1630] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.669E-3 4.826E-2
3.430E-1
1.000E0
 1 17
36 M14973 Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC1 [GeneID=3065] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.742E-3 4.826E-2
3.430E-1
1.000E0
 2 457
37 M1412 Genes up-regulated in long term hematopoietic stem cells (LT-HSC) compared to multipotent progenitor (MPP) cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.100E-3 4.826E-2
3.430E-1
1.000E0
 1 19
38 M2562 Genes distinguishing vincristine [PubChem=5978] resistant and sensitive ALL (B- and T-lineage ALL); here - genes down-regulated in the drug resistant samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.100E-3 4.826E-2
3.430E-1
1.000E0
 1 19
39 18535662-TableS1b Mouse Lymphoma Wu08 1114genes GeneSigDB 4.377E-3 4.826E-2
3.430E-1
1.000E0
 2 495
40 M5754 Genes down-regulated more than two-fold in lymphoblastoid cell lines from European population compared to those from Asian population. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.530E-3 4.826E-2
3.430E-1
1.000E0
 1 21
41 M1588 Cluster 4: genes down-regulated in SW260 cells (colon cancer) by sodium butyrate and sulindac [PubChem=5222465;5352]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.530E-3 4.826E-2
3.430E-1
1.000E0
 1 21
42 M2082 Genes whose expression in primary ER(+) [GeneID=2099] breast cancer tumors positively correlates with developing distant metastases. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.746E-3 4.826E-2
3.430E-1
1.000E0
 1 22
43 17700529-Table2 Human Breast Williams08 35genes ERInduction GeneSigDB 5.176E-3 4.826E-2
3.430E-1
1.000E0
 1 24
44 M1627 Genes down-regulated in MEF cells (embryonic fibroblast) upon Cre-lox knockout of DNMT1 [GeneID=1786]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.391E-3 4.826E-2
3.430E-1
1.000E0
 1 25
45 16760442-SuppTable5-1 Human Lymphoma Hummel06 50genes GeneSigDB 6.467E-3 4.826E-2
3.430E-1
1.000E0
 1 30
46 15548776-Figure3a Human Lymphoma Sandeep04 43genes GeneSigDB 6.682E-3 4.826E-2
3.430E-1
1.000E0
 1 31
47 M1595 Up-regulated genes in non-neoplastic mucosa samples from colon cancer patients who developed recurrence of the disease. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.897E-3 4.826E-2
3.430E-1
1.000E0
 1 32
48 15886297-Table1 Human Endometrial Takai05 36genes GeneSigDB 7.112E-3 4.826E-2
3.430E-1
1.000E0
 1 33
49 17880687-TableS6 Human Embryo Heim07 40genes PValueRank GeneSigDB 7.327E-3 4.826E-2
3.430E-1
1.000E0
 1 34
50 M6438 Genes down-regulated in hepatocellular carcinoma (HCC) cell lines resistant to IFNA2 [GeneID=3440]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.327E-3 4.826E-2
3.430E-1
1.000E0
 1 34
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 815 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ Lymphoid UNK Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ Lymphoid UNK Top 200 Genes 1.495E-5 1.218E-2
8.869E-2
 1.218E-2 3 252
2 10X Human 68K PBMC CD4+/CD25 T Reg Subtype CD4+/CD25 T Reg-CD4+/CD25 T Reg c1 Top 200 Genes 10X Human 68K PBMC CD4+/CD25 T Reg Subtype CD4+/CD25 T Reg-CD4+/CD25 T Reg c1 Top 200 Genes 5.302E-5 2.135E-2
1.555E-1
 4.321E-2 3 385
3 Facebase RNAseq e8.5 Floor Plate 2500 K1 FacebaseRNAseq e8.5 Floor Plate top-relative-expression-ranked 2500 k-means-cluster#1 FaceBase_RNAseq 9.543E-5 2.135E-2
1.555E-1
7.777E-2
 3 469
4 Human Cell Atlas Human Cell Atlas Immune Immune Top 200 Human Cell Atlas Human Cell Atlas Immune Immune Top 200 1.048E-4 2.135E-2
1.555E-1
8.541E-2
 3 484
5 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal VHL RCC Nephrogenesis/Kidney Normal VHL RCC F4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal VHL RCC Nephrogenesis/Kidney Normal VHL RCC F4 Adult, Development, and Cancer types 2.291E-4 3.734E-2
2.718E-1
1.867E-1
 1 1

15: Computational [Display Chart] 5 input genes in category / 47 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13406 GNF2 RFC3 Neighborhood of RFC3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.615E-4 3.985E-3 1.769E-2 7.593E-3 2 41
2 M18640 GNF2 MLH1 Neighborhood of MLH1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.696E-4 3.985E-3 1.769E-2 7.971E-3 2 42
3 M5444 GNF2 RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.474E-4 5.442E-3 2.415E-2 1.633E-2 2 60
4 M12856 GNF2 SMC4L1 Neighborhood of SMC4L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.809E-4 7.673E-3 3.405E-2 3.200E-2 2 84
5 M8078 GNF2 APEX1 Neighborhood of APEX1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.163E-4 7.673E-3 3.405E-2 3.837E-2 2 92
6 M4092 MODULE 197 Genes in the cancer module 197. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.887E-3 2.262E-2
1.004E-1
1.357E-1
 2 174
7 M18997 MORF XRCC5 Neighborhood of XRCC5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.167E-3 3.112E-2
1.381E-1
2.428E-1
 2 234
8 M4550 MODULE 252 TFs and nuclear. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.297E-3 3.112E-2
1.381E-1
2.490E-1
 2 237
9 M17658 MODULE 198 Genes in the cancer module 198. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.551E-3 4.466E-2
1.982E-1
4.019E-1
 2 303
10 M5502 MODULE 371 Genes in the cancer module 371. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.289E-2 4.746E-2
2.106E-1
6.057E-1
 1 26
11 M6308 GNF2 RPA1 Neighborhood of RPA1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.387E-2 4.746E-2
2.106E-1
6.521E-1
 1 28
12 M15268 MODULE 281 Phosphatase regulators. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.387E-2 4.746E-2
2.106E-1
6.521E-1
 1 28
13 M10242 GNF2 MSH2 Neighborhood of MSH2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.387E-2 4.746E-2
2.106E-1
6.521E-1
 1 28
14 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.414E-2 4.746E-2
2.106E-1
6.644E-1
 2 393
Show 9 more annotations

16: MicroRNA [Display Chart] 5 input genes in category / 393 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-4424:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.073E-8 4.217E-6 2.763E-5 4.217E-6 3 75
2 hsa-miR-1178-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.501E-6 8.844E-4 5.795E-3 1.769E-3 2 49
3 hsa-miR-499a-5p:Functional MTI Functional MTI miRTarbase 7.713E-6 1.010E-3 6.620E-3 3.031E-3 2 64
4 hsa-miR-6128:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.817E-5 1.785E-3 1.170E-2 7.140E-3 2 98
5 hsa-miR-6798-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.727E-5 2.026E-3 1.328E-2 1.072E-2 2 120
6 hsa-miR-556-5p:PITA hsa-miR-556-5p:PITA TOP PITA 3.252E-5 2.026E-3 1.328E-2 1.278E-2 2 131
7 hsa-miR-494-3p:Functional MTI Functional MTI miRTarbase 3.609E-5 2.026E-3 1.328E-2 1.418E-2 2 138
8 hsa-miR-200a-3p:Functional MTI Functional MTI miRTarbase 4.265E-5 2.093E-3 1.371E-2 1.676E-2 2 150
9 hsa-miR-212-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.793E-5 2.093E-3 1.371E-2 1.884E-2 2 159
10 TTTGCAG,MIR-518A-2:MSigDB TTTGCAG,MIR-518A-2:MSigDB MSigDB 7.359E-5 2.892E-3 1.895E-2 2.892E-2 2 197
11 hsa-miR-501-5p:PITA hsa-miR-501-5p:PITA TOP PITA 2.188E-4 7.592E-3 4.974E-2
8.599E-2
 2 340
12 hsa-miR-18a-3p:Functional MTI Functional MTI miRTarbase 2.318E-4 7.592E-3 4.974E-2
9.110E-2
 2 350
13 hsa-miR-181c*:mirSVR lowEffct hsa-miR-181c*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 4.402E-4 1.331E-2
8.719E-2
1.730E-1
 2 483
14 AGCGCAG,MIR-191:MSigDB AGCGCAG,MIR-191:MSigDB MSigDB 8.303E-4 2.331E-2
1.527E-1
3.263E-1
 1 12
15 hsa-miR-4798-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.686E-4 2.500E-2
1.638E-1
3.807E-1
 1 14
16 hsa-miR-3912-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.038E-3 2.500E-2
1.638E-1
4.079E-1
 1 15
17 hsa-miR-639:PITA hsa-miR-639:PITA TOP PITA 1.660E-3 2.500E-2
1.638E-1
6.524E-1
 1 24
18 hsa-miR-191-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.729E-3 2.500E-2
1.638E-1
6.796E-1
 1 25
19 hsa-miR-6763-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.937E-3 2.500E-2
1.638E-1
7.610E-1
 1 28
20 hsa-miR-3200-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.351E-3 2.500E-2
1.638E-1
9.240E-1
 1 34
21 hsa-miR-374c-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.489E-3 2.500E-2
1.638E-1
9.783E-1
 1 36
22 hsa-miR-509-3p:Functional MTI Functional MTI miRTarbase 2.835E-3 2.500E-2
1.638E-1
1.000E0
 1 41
23 hsa-miR-6892-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.904E-3 2.500E-2
1.638E-1
1.000E0
 1 42
24 hsa-miR-6767-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.111E-3 2.500E-2
1.638E-1
1.000E0
 1 45
25 hsa-miR-4727-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.111E-3 2.500E-2
1.638E-1
1.000E0
 1 45
26 hsa-miR-4460:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.249E-3 2.500E-2
1.638E-1
1.000E0
 1 47
27 hsa-miR-3670:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.318E-3 2.500E-2
1.638E-1
1.000E0
 1 48
28 hsa-miR-208b-3p:Functional MTI Functional MTI miRTarbase 3.387E-3 2.500E-2
1.638E-1
1.000E0
 1 49
29 hsa-miR-376a-2-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.387E-3 2.500E-2
1.638E-1
1.000E0
 1 49
30 hsa-miR-4633-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.456E-3 2.500E-2
1.638E-1
1.000E0
 1 50
31 hsa-miR-6500-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.456E-3 2.500E-2
1.638E-1
1.000E0
 1 50
32 hsa-miR-6874-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.456E-3 2.500E-2
1.638E-1
1.000E0
 1 50
33 hsa-miR-3677-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.732E-3 2.500E-2
1.638E-1
1.000E0
 1 54
34 hsa-miR-208a-3p:Functional MTI Functional MTI miRTarbase 3.732E-3 2.500E-2
1.638E-1
1.000E0
 1 54
35 GTAAGAT,MIR-200A:MSigDB GTAAGAT,MIR-200A:MSigDB MSigDB 3.732E-3 2.500E-2
1.638E-1
1.000E0
 1 54
36 hsa-miR-891b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.939E-3 2.500E-2
1.638E-1
1.000E0
 1 57
37 hsa-miR-4509:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.939E-3 2.500E-2
1.638E-1
1.000E0
 1 57
38 hsa-miR-500b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.008E-3 2.500E-2
1.638E-1
1.000E0
 1 58
39 hsa-miR-647:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.008E-3 2.500E-2
1.638E-1
1.000E0
 1 58
40 hsa-miR-34c-3p:Functional MTI Functional MTI miRTarbase 4.008E-3 2.500E-2
1.638E-1
1.000E0
 1 58
41 hsa-miR-1179:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.077E-3 2.500E-2
1.638E-1
1.000E0
 1 59
42 hsa-miR-362-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.353E-3 2.500E-2
1.638E-1
1.000E0
 1 63
43 hsa-miR-3690:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.353E-3 2.500E-2
1.638E-1
1.000E0
 1 63
44 GCAAGGA,MIR-502:MSigDB GCAAGGA,MIR-502:MSigDB MSigDB 4.422E-3 2.500E-2
1.638E-1
1.000E0
 1 64
45 hsa-miR-3127-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.422E-3 2.500E-2
1.638E-1
1.000E0
 1 64
46 hsa-miR-3152-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-3 2.500E-2
1.638E-1
1.000E0
 1 66
47 hsa-miR-4275:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-3 2.500E-2
1.638E-1
1.000E0
 1 66
48 hsa-miR-101-5p:Functional MTI Functional MTI miRTarbase 4.698E-3 2.500E-2
1.638E-1
1.000E0
 1 68
49 hsa-miR-2861:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.698E-3 2.500E-2
1.638E-1
1.000E0
 1 68
50 hsa-miR-4679:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.767E-3 2.500E-2
1.638E-1
1.000E0
 1 69
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 840 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000161113 d(GpG Stitch 2.307E-11 1.938E-8 1.417E-7 1.938E-8 4 35
2 CID003496889 Amphoterin Stitch 6.536E-9 1.873E-6 1.369E-5 5.490E-6 4 139
3 CID000083911 AC1L36FJ Stitch 6.690E-9 1.873E-6 1.369E-5 5.619E-6 3 21
4 CID000068037 6-azauracil Stitch 2.990E-7 6.278E-5 4.590E-4 2.511E-4 3 72
5 CID000041322 anti-BaPDE Stitch 1.046E-5 1.757E-3 1.284E-2 8.783E-3 3 234
6 CID000447956 2c5o Stitch 1.867E-5 2.614E-3 1.911E-2 1.569E-2 3 284
7 ctd:D001786 Blood Glucose CTD 7.687E-5 9.224E-3
6.744E-2
6.457E-2
 2 64
8 CID011497471 R A J Stitch 1.029E-4 1.080E-2
7.899E-2
8.643E-2
 2 74
9 CID000003115 Stallimycin Stitch 1.203E-4 1.123E-2
8.210E-2
1.011E-1
 2 80
10 CID000003017 diazinon Stitch 1.807E-4 1.518E-2
1.110E-1
1.518E-1
 2 98
11 CID000050261 AC1L18R8 Stitch 2.074E-4 1.584E-2
1.158E-1
1.742E-1
 2 105
12 ctd:C027561 butylbenzyl phthalate CTD 2.360E-4 1.652E-2
1.208E-1
1.983E-1
 2 112
13 CID000098527 Nexus Stitch 4.342E-4 2.206E-2
1.613E-1
3.647E-1
 2 152
14 CID002760820 trimethyl(pentafluoroethyl)silane Stitch 4.378E-4 2.206E-2
1.613E-1
3.677E-1
 1 2
15 CID000196575 D-HMG Stitch 4.378E-4 2.206E-2
1.613E-1
3.677E-1
 1 2
16 ctd:C007095 cobaltiprotoporphyrin CTD 4.991E-4 2.206E-2
1.613E-1
4.192E-1
 2 163
17 CID000000750 glycine Stitch 5.363E-4 2.206E-2
1.613E-1
4.505E-1
 2 169
18 ctd:D002084 Butylated Hydroxytoluene CTD 6.013E-4 2.206E-2
1.613E-1
5.051E-1
 2 179
19 CID000023939 platinum Stitch 6.284E-4 2.206E-2
1.613E-1
5.278E-1
 2 183
20 CID000000945 nitroxyl Stitch 6.421E-4 2.206E-2
1.613E-1
5.394E-1
 2 185
21 ctd:C425776 tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone CTD 6.566E-4 2.206E-2
1.613E-1
5.515E-1
 1 3
22 CID000037829 dichlormid Stitch 6.566E-4 2.206E-2
1.613E-1
5.515E-1
 1 3
23 CID004484391 forsythoside A Stitch 6.566E-4 2.206E-2
1.613E-1
5.515E-1
 1 3
24 ctd:C583240 emodin-6-O-glucoside CTD 6.566E-4 2.206E-2
1.613E-1
5.515E-1
 1 3
25 ctd:C440499 lipopolysaccharide, Escherichia coli O111 B4 CTD 6.842E-4 2.206E-2
1.613E-1
5.747E-1
 2 191
26 1567 DN Methylprednisolone, 6-alpha [83-43-2]; Down 200; 10.6uM; HL60; HG-U133A Broad Institute CMAP Down 7.203E-4 2.206E-2
1.613E-1
6.050E-1
 2 196
27 4540 UP Tolbutamide [64-77-7]; Up 200; 14.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.276E-4 2.206E-2
1.613E-1
6.112E-1
 2 197
28 CID000083746 samarium iodide Stitch 8.754E-4 2.206E-2
1.613E-1
7.353E-1
 1 4
29 CID000448087 Ti 3 Stitch 8.754E-4 2.206E-2
1.613E-1
7.353E-1
 1 4
30 CID000101712 phillyrin Stitch 8.754E-4 2.206E-2
1.613E-1
7.353E-1
 1 4
31 CID000096621 IaraU Stitch 8.754E-4 2.206E-2
1.613E-1
7.353E-1
 1 4
32 CID000137994 tempol Stitch 9.142E-4 2.206E-2
1.613E-1
7.680E-1
 2 221
33 CID000000193 S-adenosyl-D-homocysteine Stitch 9.225E-4 2.206E-2
1.613E-1
7.749E-1
 2 222
34 CID000000593 NSC20261 Stitch 9.390E-4 2.206E-2
1.613E-1
7.888E-1
 2 224
35 CID000005486 AC1L1KGC Stitch 9.474E-4 2.206E-2
1.613E-1
7.958E-1
 2 225
36 CID000014403 NSC529592 Stitch 1.024E-3 2.206E-2
1.613E-1
8.602E-1
 2 234
37 ctd:C097256 semapimod CTD 1.094E-3 2.206E-2
1.613E-1
9.191E-1
 1 5
38 ctd:D012263 Ribonucleosides CTD 1.094E-3 2.206E-2
1.613E-1
9.191E-1
 1 5
39 ctd:C575430 FH535 CTD 1.094E-3 2.206E-2
1.613E-1
9.191E-1
 1 5
40 ctd:C083174 erionite CTD 1.094E-3 2.206E-2
1.613E-1
9.191E-1
 1 5
41 ctd:D008550 Melatonin CTD 1.131E-3 2.206E-2
1.613E-1
9.499E-1
 2 246
42 ctd:C005460 uranyl acetate CTD 1.243E-3 2.206E-2
1.613E-1
1.000E0
 2 258
43 CID000014819 lead sulfide Stitch 1.262E-3 2.206E-2
1.613E-1
1.000E0
 2 260
44 ctd:D000171 Acrolein CTD 1.262E-3 2.206E-2
1.613E-1
1.000E0
 2 260
45 CID000340930 NSC372203 Stitch 1.313E-3 2.206E-2
1.613E-1
1.000E0
 1 6
46 CID000016584 pentachloropyridine Stitch 1.313E-3 2.206E-2
1.613E-1
1.000E0
 1 6
47 ctd:C064309 kaempferol 3-O-sophoroside CTD 1.313E-3 2.206E-2
1.613E-1
1.000E0
 1 6
48 CID000012694 dichloroacetamide Stitch 1.313E-3 2.206E-2
1.613E-1
1.000E0
 1 6
49 CID000130202 2-FFI Stitch 1.313E-3 2.206E-2
1.613E-1
1.000E0
 1 6
50 ctd:C403944 cynandione A CTD 1.313E-3 2.206E-2
1.613E-1
1.000E0
 1 6
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 250 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0024137 Lupus Erythematosus, Cutaneous DisGeNET BeFree 1.142E-6 2.855E-4 1.742E-3 2.855E-4 2 6
2 C0008373 Cholesteatoma DisGeNET Curated 4.184E-6 4.184E-4 2.552E-3 1.046E-3 2 11
3 C0265797 Congenital emphysema DisGeNET BeFree 5.021E-6 4.184E-4 2.552E-3 1.255E-3 2 12
4 C1858991 Childhood Ataxia with Central Nervous System Hypomyelinization DisGeNET Curated 2.096E-5 1.139E-3 6.950E-3 5.241E-3 2 24
5 C3850141 Acute-On-Chronic Liver Failure DisGeNET BeFree 2.278E-5 1.139E-3 6.950E-3 5.696E-3 2 25
6 C0856742 post mi DisGeNET BeFree 7.840E-5 3.051E-3 1.861E-2 1.960E-2 2 46
7 C0086981 Sicca Syndrome DisGeNET BeFree 8.543E-5 3.051E-3 1.861E-2 2.136E-2 2 48
8 C0036690 Septicemia DisGeNET Curated 2.040E-4 6.376E-3 3.890E-2
5.101E-2
 3 450
9 C0243026 Sepsis DisGeNET Curated 2.755E-4 7.323E-3 4.467E-2
6.887E-2
 3 498
10 C0264939 Systemic Vasculitis DisGeNET Curated 3.085E-4 7.323E-3 4.467E-2
7.714E-2
 1 1
11 C0920646 Renal ischaemia DisGeNET BeFree 3.222E-4 7.323E-3 4.467E-2
8.055E-2
 2 93
12 C0729527 Bacterial oral infection DisGeNET BeFree 6.170E-4 1.028E-2
6.274E-2
1.543E-1
 1 2
13 C1367536 Nasopharyngeal Angiofibroma DisGeNET BeFree 6.170E-4 1.028E-2
6.274E-2
1.543E-1
 1 2
14 C4054590 Lupus Flare DisGeNET BeFree 6.170E-4 1.028E-2
6.274E-2
1.543E-1
 1 2
15 C0008439 Chondritis DisGeNET BeFree 6.170E-4 1.028E-2
6.274E-2
1.543E-1
 1 2
16 C0947751 Vascular inflammations DisGeNET BeFree 7.599E-4 1.187E-2
7.244E-2
1.900E-1
 2 143
17 C0279671 Cervical Squamous Cell Carcinoma DisGeNET BeFree 8.806E-4 1.218E-2
7.428E-2
2.201E-1
 2 154
18 C3890429 Liquid Tumor DisGeNET BeFree 9.254E-4 1.218E-2
7.428E-2
2.314E-1
 1 3
19 C0036503 Sebaceous Gland Neoplasms DisGeNET Curated 9.254E-4 1.218E-2
7.428E-2
2.314E-1
 1 3
20 C0279625 adult acute promyelocytic leukemia (M3) DisGeNET BeFree 1.234E-3 1.402E-2
8.553E-2
3.084E-1
 1 4
21 C1518004 Low Grade B-Cell Non-Hodgkin's Lymphoma DisGeNET BeFree 1.234E-3 1.402E-2
8.553E-2
3.084E-1
 1 4
22 C1334243 Intracranial Melanoma DisGeNET BeFree 1.234E-3 1.402E-2
8.553E-2
3.084E-1
 1 4
23 C1327920 childhood chronic myelogenous leukemia DisGeNET BeFree 1.850E-3 1.851E-2
1.129E-1
4.625E-1
 1 6
24 C1621719 Lymphoepithelioid lymphoma (clinical) DisGeNET BeFree 1.850E-3 1.851E-2
1.129E-1
4.625E-1
 1 6
25 C1527336 Sjogren's Syndrome DisGeNET Curated 1.851E-3 1.851E-2
1.129E-1
4.627E-1
 2 224
26 C0026766 Multiple Organ Failure DisGeNET Curated 2.158E-3 2.075E-2
1.266E-1
5.396E-1
 1 7
27 C0019159 Hepatitis A DisGeNET BeFree 2.465E-3 2.126E-2
1.297E-1
6.162E-1
 2 259
28 C1959583 Myocardial Failure DisGeNET BeFree 2.466E-3 2.126E-2
1.297E-1
6.166E-1
 1 8
29 C1850383 Neuropathy, Painful DisGeNET Curated 2.466E-3 2.126E-2
1.297E-1
6.166E-1
 1 8
30 C1709527 B Acute Lymphoblastic Leukemia with t(9;22)(q34;q11.2); BCR-ABL1 DisGeNET BeFree 2.774E-3 2.167E-2
1.322E-1
6.935E-1
 1 9
31 C0206711 Pilomatrixoma DisGeNET Curated 2.774E-3 2.167E-2
1.322E-1
6.935E-1
 1 9
32 C2267231 Chronic idiopathic neutropenia DisGeNET BeFree 2.774E-3 2.167E-2
1.322E-1
6.935E-1
 1 9
33 C0265286 Dyggve-Melchior-Clausen syndrome DisGeNET Curated 3.082E-3 2.230E-2
1.361E-1
7.705E-1
 1 10
34 C0409974 Lupus Erythematosus DisGeNET BeFree 3.206E-3 2.230E-2
1.361E-1
8.016E-1
 2 296
35 C1368683 Epithelioma DisGeNET BeFree 3.249E-3 2.230E-2
1.361E-1
8.123E-1
 2 298
36 C3854181 Nevus sebaceous DisGeNET Curated 3.390E-3 2.230E-2
1.361E-1
8.475E-1
 1 11
37 C0555278 Cerebral metastasis DisGeNET BeFree 3.390E-3 2.230E-2
1.361E-1
8.475E-1
 1 11
38 C0027613 Neonatal hepatitis DisGeNET Curated 3.390E-3 2.230E-2
1.361E-1
8.475E-1
 1 11
39 C0004763 Barrett Esophagus DisGeNET Curated 3.578E-3 2.255E-2
1.375E-1
8.946E-1
 2 313
40 C0400966 Non-alcoholic Fatty Liver Disease DisGeNET Curated 3.669E-3 2.255E-2
1.375E-1
9.172E-1
 2 317
41 C2931673 Ceroid lipofuscinosis, neuronal 1, infantile DisGeNET Curated 3.698E-3 2.255E-2
1.375E-1
9.244E-1
 1 12
42 C0034103 Pulpitis DisGeNET BeFree 4.005E-3 2.384E-2
1.454E-1
1.000E0
 1 13
43 C1561643 Chronic Kidney Diseases DisGeNET Curated 4.209E-3 2.396E-2
1.462E-1
1.000E0
 2 340
44 C0029191 Orchitis DisGeNET Curated 4.313E-3 2.396E-2
1.462E-1
1.000E0
 1 14
45 C3532239 Mitochondrial cardiomyopathy DisGeNET BeFree 4.313E-3 2.396E-2
1.462E-1
1.000E0
 1 14
46 C0005398 Cholestasis, Extrahepatic DisGeNET BeFree 4.620E-3 2.511E-2
1.532E-1
1.000E0
 1 15
47 C0178238 Intestinal infectious disease (disorder) DisGeNET BeFree 4.928E-3 2.566E-2
1.566E-1
1.000E0
 1 16
48 C1739363 Prostatic Hypertrophy DisGeNET BeFree 4.928E-3 2.566E-2
1.566E-1
1.000E0
 1 16
49 C0015695 Fatty Liver DisGeNET Curated 5.233E-3 2.566E-2
1.566E-1
1.000E0
 2 380
50 C0597984 Biliary stricture DisGeNET BeFree 5.235E-3 2.566E-2
1.566E-1
1.000E0
 1 17
Show 45 more annotations