Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc277_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 69 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004598 peptidylamidoglycolate lyase activity 3.751E-4 1.294E-2
6.236E-2
 2.588E-2 1 1
2 GO:0004504 peptidylglycine monooxygenase activity 3.751E-4 1.294E-2
6.236E-2
 2.588E-2 1 1
3 GO:0016842 amidine-lyase activity 1.125E-3 2.587E-2
1.247E-1
7.762E-2
 1 3
4 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen 1.874E-3 2.930E-2
1.412E-1
1.293E-1
 1 5
5 GO:0030492 hemoglobin binding 2.998E-3 2.930E-2
1.412E-1
2.068E-1
 1 8
6 GO:0031406 carboxylic acid binding 3.315E-3 2.930E-2
1.412E-1
2.287E-1
 2 240
7 GO:0016840 carbon-nitrogen lyase activity 3.372E-3 2.930E-2
1.412E-1
2.326E-1
 1 9
8 GO:0043177 organic acid binding 3.397E-3 2.930E-2
1.412E-1
2.344E-1
 2 243
9 GO:0070300 phosphatidic acid binding 4.867E-3 3.358E-2
1.618E-1
3.358E-1
 1 13
10 GO:0010314 phosphatidylinositol-5-phosphate binding 4.867E-3 3.358E-2
1.618E-1
3.358E-1
 1 13
11 GO:0015278 calcium-release channel activity 5.987E-3 3.443E-2
1.659E-1
4.131E-1
 1 16
12 GO:0099604 ligand-gated calcium channel activity 5.987E-3 3.443E-2
1.659E-1
4.131E-1
 1 16
13 GO:0030275 LRR domain binding 7.479E-3 3.547E-2
1.709E-1
5.161E-1
 1 20
14 GO:0031418 L-ascorbic acid binding 7.852E-3 3.547E-2
1.709E-1
5.418E-1
 1 21
15 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 8.225E-3 3.547E-2
1.709E-1
5.675E-1
 1 22
16 GO:0070273 phosphatidylinositol-4-phosphate binding 8.225E-3 3.547E-2
1.709E-1
5.675E-1
 1 22
17 GO:0005217 intracellular ligand-gated ion channel activity 1.120E-2 4.472E-2
2.155E-1
7.729E-1
 1 30
18 GO:0032266 phosphatidylinositol-3-phosphate binding 1.194E-2 4.472E-2
2.155E-1
8.241E-1
 1 32
19 GO:0001786 phosphatidylserine binding 1.232E-2 4.472E-2
2.155E-1
8.498E-1
 1 33
Show 14 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 271 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0050850 positive regulation of calcium-mediated signaling 1.244E-4 1.697E-2
1.049E-1
 3.370E-2 2 46
2 GO:0055024 regulation of cardiac muscle tissue development 2.491E-4 1.697E-2
1.049E-1
6.750E-2
 2 65
3 GO:0007517 muscle organ development 3.348E-4 1.697E-2
1.049E-1
9.074E-2
 3 405
4 GO:0018032 protein amidation 3.759E-4 1.697E-2
1.049E-1
1.019E-1
 1 1
5 GO:0050848 regulation of calcium-mediated signaling 4.260E-4 1.697E-2
1.049E-1
1.154E-1
 2 85
6 GO:0006581 acetylcholine catabolic process 7.516E-4 1.697E-2
1.049E-1
2.037E-1
 1 2
7 GO:2000296 negative regulation of hydrogen peroxide catabolic process 7.516E-4 1.697E-2
1.049E-1
2.037E-1
 1 2
8 GO:0001507 acetylcholine catabolic process in synaptic cleft 7.516E-4 1.697E-2
1.049E-1
2.037E-1
 1 2
9 GO:0001928 regulation of exocyst assembly 7.516E-4 1.697E-2
1.049E-1
2.037E-1
 1 2
10 GO:0021893 cerebral cortex GABAergic interneuron fate commitment 7.516E-4 1.697E-2
1.049E-1
2.037E-1
 1 2
11 GO:0001519 peptide amidation 7.516E-4 1.697E-2
1.049E-1
2.037E-1
 1 2
12 GO:0016202 regulation of striated muscle tissue development 9.181E-4 1.697E-2
1.049E-1
2.488E-1
 2 125
13 GO:0048634 regulation of muscle organ development 9.475E-4 1.697E-2
1.049E-1
2.568E-1
 2 127
14 GO:1901861 regulation of muscle tissue development 9.624E-4 1.697E-2
1.049E-1
2.608E-1
 2 128
15 GO:0042476 odontogenesis 9.774E-4 1.697E-2
1.049E-1
2.649E-1
 2 129
16 GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment 1.127E-3 1.697E-2
1.049E-1
3.055E-1
 1 3
17 GO:2000295 regulation of hydrogen peroxide catabolic process 1.127E-3 1.697E-2
1.049E-1
3.055E-1
 1 3
18 GO:0031179 peptide modification 1.127E-3 1.697E-2
1.049E-1
3.055E-1
 1 3
19 GO:0001927 exocyst assembly 1.503E-3 2.005E-2
1.239E-1
4.073E-1
 1 4
20 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain 1.503E-3 2.005E-2
1.239E-1
4.073E-1
 1 4
21 GO:0019722 calcium-mediated signaling 1.553E-3 2.005E-2
1.239E-1
4.210E-1
 2 163
22 GO:0007219 Notch signaling pathway 1.828E-3 2.213E-2
1.368E-1
4.954E-1
 2 177
23 GO:0008582 regulation of synaptic growth at neuromuscular junction 1.878E-3 2.213E-2
1.368E-1
5.090E-1
 1 5
24 GO:0051124 synaptic growth at neuromuscular junction 2.629E-3 2.595E-2
1.604E-1
7.124E-1
 1 7
25 GO:1900619 acetate ester metabolic process 2.629E-3 2.595E-2
1.604E-1
7.124E-1
 1 7
26 GO:0008291 acetylcholine metabolic process 2.629E-3 2.595E-2
1.604E-1
7.124E-1
 1 7
27 GO:0010727 negative regulation of hydrogen peroxide metabolic process 2.629E-3 2.595E-2
1.604E-1
7.124E-1
 1 7
28 GO:0048738 cardiac muscle tissue development 2.682E-3 2.595E-2
1.604E-1
7.267E-1
 2 215
29 GO:1904396 regulation of neuromuscular junction development 3.004E-3 2.807E-2
1.735E-1
8.140E-1
 1 8
30 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity 3.379E-3 3.052E-2
1.886E-1
9.156E-1
 1 9
31 GO:0042135 neurotransmitter catabolic process 3.753E-3 3.223E-2
1.992E-1
1.000E0
 1 10
32 GO:0019932 second-messenger-mediated signaling 3.806E-3 3.223E-2
1.992E-1
1.000E0
 2 257
33 GO:0050803 regulation of synapse structure or activity 4.252E-3 3.486E-2
2.155E-1
1.000E0
 2 272
34 GO:0071340 skeletal muscle acetylcholine-gated channel clustering 4.503E-3 3.486E-2
2.155E-1
1.000E0
 1 12
35 GO:0021892 cerebral cortex GABAergic interneuron differentiation 4.503E-3 3.486E-2
2.155E-1
1.000E0
 1 12
36 GO:0021877 forebrain neuron fate commitment 5.251E-3 3.745E-2
2.315E-1
1.000E0
 1 14
37 GO:0048715 negative regulation of oligodendrocyte differentiation 5.251E-3 3.745E-2
2.315E-1
1.000E0
 1 14
38 GO:0009404 toxin metabolic process 5.251E-3 3.745E-2
2.315E-1
1.000E0
 1 14
39 GO:0097154 GABAergic neuron differentiation 5.625E-3 3.909E-2
2.416E-1
1.000E0
 1 15
40 GO:0021794 thalamus development 6.000E-3 3.966E-2
2.451E-1
1.000E0
 1 16
41 GO:0010310 regulation of hydrogen peroxide metabolic process 6.000E-3 3.966E-2
2.451E-1
1.000E0
 1 16
42 GO:0060218 hematopoietic stem cell differentiation 6.373E-3 4.112E-2
2.542E-1
1.000E0
 1 17
43 GO:0048638 regulation of developmental growth 6.681E-3 4.211E-2
2.603E-1
1.000E0
 2 343
44 GO:0060850 regulation of transcription involved in cell fate commitment 7.495E-3 4.515E-2
2.791E-1
1.000E0
 1 20
45 GO:0010038 response to metal ion 7.497E-3 4.515E-2
2.791E-1
1.000E0
 2 364
46 GO:0060045 positive regulation of cardiac muscle cell proliferation 7.868E-3 4.537E-2
2.804E-1
1.000E0
 1 21
47 GO:0010288 response to lead ion 7.868E-3 4.537E-2
2.804E-1
1.000E0
 1 21
48 GO:1901032 negative regulation of response to reactive oxygen species 8.615E-3 4.764E-2
2.945E-1
1.000E0
 1 23
49 GO:0021895 cerebral cortex neuron differentiation 8.615E-3 4.764E-2
2.945E-1
1.000E0
 1 23
50 GO:0014706 striated muscle tissue development 8.868E-3 4.776E-2
2.952E-1
1.000E0
 2 397
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 35 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031838 haptoglobin-hemoglobin complex 1.468E-3 3.209E-2
1.331E-1
5.139E-2
 1 4
2 GO:0030314 junctional membrane complex 2.935E-3 3.209E-2
1.331E-1
1.027E-1
 1 8
3 GO:0043083 synaptic cleft 3.667E-3 3.209E-2
1.331E-1
1.284E-1
 1 10
4 GO:0014701 junctional sarcoplasmic reticulum membrane 3.667E-3 3.209E-2
1.331E-1
1.284E-1
 1 10
5 GO:0071682 endocytic vesicle lumen 6.227E-3 4.359E-2
1.808E-1
2.180E-1
 1 17

4: Human Phenotype [Display Chart] 3 input genes in category / 113 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 6 input genes in category / 243 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 7 input genes in category / 85 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR030485 CHD2 InterPro 3.736E-4 4.762E-3 2.393E-2 3.176E-2 1 1
2 IPR000720 PHM/PAL InterPro 3.736E-4 4.762E-3 2.393E-2 3.176E-2 1 1
3 IPR033019 Ncam1 InterPro 3.736E-4 4.762E-3 2.393E-2 3.176E-2 1 1
4 IPR014783 Cu2 ascorb mOase CS-2 InterPro 7.471E-4 4.762E-3 2.393E-2
6.351E-2
 1 2
5 IPR008292 Haptoglobin InterPro 7.471E-4 4.762E-3 2.393E-2
6.351E-2
 1 2
6 PF01082 Cu2 monooxygen Pfam 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
7 IPR000323 Cu2 ascorb mOase N InterPro 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
8 PS00084 CU2 MONOOXYGENASE 1 PROSITE 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
9 SM01176 DUF4208 SMART 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
10 2.60.120.230 - Gene3D 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
11 PS00085 CU2 MONOOXYGENASE 2 PROSITE 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
12 IPR025260 DUF4208 InterPro 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
13 IPR011936 Myxo disulph rpt InterPro 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
14 IPR014784 Cu2 ascorb mOase-like C InterPro 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
15 2.60.120.310 - Gene3D 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
16 PF13907 DUF4208 Pfam 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
17 IPR008977 PHM/PNGase F dom InterPro 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
18 IPR024548 Cu2 monoox C InterPro 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
19 IPR020611 Cu2 ascorb mOase CS-1 InterPro 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
20 PF03712 Cu2 monoox C Pfam 1.121E-3 4.762E-3 2.393E-2
9.525E-2
 1 3
21 IPR009138 Neural cell adh InterPro 1.494E-3 5.772E-3 2.901E-2
1.270E-1
 1 4
22 IPR017191 Junctophilin InterPro 1.494E-3 5.772E-3 2.901E-2
1.270E-1
 1 4
23 IPR013017 NHL repeat subgr InterPro 3.358E-3 1.241E-2
6.238E-2
2.855E-1
 1 9
24 IPR001258 NHL repeat InterPro 3.731E-3 1.269E-2
6.375E-2
3.171E-1
 1 10
25 PF01436 NHL Pfam 3.731E-3 1.269E-2
6.375E-2
3.171E-1
 1 10
26 PS51125 NHL PROSITE 4.848E-3 1.585E-2
7.965E-2
4.121E-1
 1 13
27 SM00698 MORN SMART 5.220E-3 1.639E-2
8.237E-2
4.437E-1
 1 14
28 PF02493 MORN Pfam 5.592E-3 1.639E-2
8.237E-2
4.753E-1
 1 15
29 IPR003409 MORN InterPro 5.592E-3 1.639E-2
8.237E-2
4.753E-1
 1 15
30 IPR023779 Chromodomain CS InterPro 6.707E-3 1.900E-2
9.551E-2
5.701E-1
 1 18
31 IPR023780 Chromo domain InterPro 8.934E-3 2.450E-2
1.231E-1
7.594E-1
 1 24
32 PF00385 Chromo Pfam 9.676E-3 2.570E-2
1.292E-1
8.224E-1
 1 26
33 PS50013 CHROMO 2 PROSITE 1.042E-2 2.604E-2
1.309E-1
8.854E-1
 1 28
34 PS00598 CHROMO 1 PROSITE 1.042E-2 2.604E-2
1.309E-1
8.854E-1
 1 28
35 IPR016197 Chromodomain-like InterPro 1.190E-2 2.674E-2
1.344E-1
1.000E0
 1 32
36 IPR000330 SNF2 N InterPro 1.190E-2 2.674E-2
1.344E-1
1.000E0
 1 32
37 PF00176 SNF2 N Pfam 1.190E-2 2.674E-2
1.344E-1
1.000E0
 1 32
38 SM00298 CHROMO SMART 1.227E-2 2.674E-2
1.344E-1
1.000E0
 1 33
39 IPR000953 Chromo/shadow dom InterPro 1.227E-2 2.674E-2
1.344E-1
1.000E0
 1 33
40 IPR002464 DNA/RNA helicase DEAH CS InterPro 1.301E-2 2.764E-2
1.389E-1
1.000E0
 1 35
41 PS00690 DEAH ATP HELICASE PROSITE 1.411E-2 2.926E-2
1.471E-1
1.000E0
 1 38
42 2.120.10.30 - Gene3D 1.448E-2 2.931E-2
1.473E-1
1.000E0
 1 39
43 IPR011042 6-blade b-propeller TolB-like InterPro 1.706E-2 3.373E-2
1.695E-1
1.000E0
 1 46
44 PF00084 Sushi Pfam 1.927E-2 3.723E-2
1.871E-1
1.000E0
 1 52
45 SM00032 CCP SMART 2.001E-2 3.779E-2
1.899E-1
1.000E0
 1 54
46 PS50923 SUSHI PROSITE 2.074E-2 3.817E-2
1.918E-1
1.000E0
 1 56
47 IPR000436 Sushi SCR CCP dom InterPro 2.111E-2 3.817E-2
1.918E-1
1.000E0
 1 57
48 IPR000047 HTH motif InterPro 2.550E-2 4.516E-2
2.270E-1
1.000E0
 1 69
Show 43 more annotations

7: Pathway [Display Chart] 5 input genes in category / 58 annotations before applied cutoff / 12450 genes in category

No results to display

8: Pubmed [Display Chart] 7 input genes in category / 1661 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16540508 Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously. Pubmed 1.899E-6 4.734E-4 3.784E-3 3.154E-3 2 12
2 12533617 DLX5 regulates development of peripheral and central components of the olfactory system. Pubmed 3.911E-6 4.734E-4 3.784E-3 6.496E-3 2 17
3 22906231 Neurog1 and Neurog2 coordinately regulate development of the olfactory system. Pubmed 1.708E-5 4.734E-4 3.784E-3 2.837E-2 2 35
4 15745951 Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. Pubmed 1.809E-5 4.734E-4 3.784E-3 3.004E-2 2 36
5 20351714 Poor replication of candidate genes for major depressive disorder using genome-wide association data. Pubmed 3.655E-5 4.734E-4 3.784E-3
6.072E-2
 2 51
6 29513653 Developmental diversification of cortical inhibitory interneurons. Pubmed 9.729E-5 4.734E-4 3.784E-3
1.616E-1
 2 83
7 26499173 NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
8 19277847 Glutamate at position 227 of junctophilin-2 is involved in binding to TRPC3. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
9 17005911 Not all secretory granules are created equal: Partitioning of soluble content proteins. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
10 19743954 The prognostic utility of haptoglobin genotypes in squamous cell carcinoma of the head and neck. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
11 7917293 N-CAM mutation inhibits tangential neuronal migration and is phenocopied by enzymatic removal of polysialic acid. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
12 23223086 Haptoglobin polymorphism affects nitric oxide bioavailability in preeclampsia. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
13 25783594 CHD2 variants are a risk factor for photosensitivity in epilepsy. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
14 11399310 Genetic deletions of NCAM and PSA impair circadian function in the mouse. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
15 7873888 Localization of the peptidylglycine alpha-amidating monooxygenase gene (Pam) introduces a region of homology between human chromosome 5q and mouse chromosome 1. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
16 19801537 Haptoglobin expression in endometrioid adenocarcinoma of the uterus. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
17 18213713 Neural cell adhesion molecule (NCAM) isoform expression is associated with neuroblastoma differentiation status. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
18 21515372 Transgenic mice overexpressing the extracellular domain of NCAM are impaired in working memory and cortical plasticity. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
19 8954715 Neuronal pathfinding and recognition: roles of cell adhesion molecules. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
20 11564959 Association between Cys282Tyr missense mutation and haptoglobin phenotype polymorphism in patients with chronic hepatitis C. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
21 16181411 Modulation of the homophilic interaction between the first and second Ig modules of neural cell adhesion molecule by heparin. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
22 19142019 A mutation in the mouse Chd2 chromatin remodeling enzyme results in a complex renal phenotype. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
23 23504516 Age-related cognitive impairments in mice with a conditional ablation of the neural cell adhesion molecule. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
24 10964958 Structural and functional alterations of neuromuscular junctions in NCAM-deficient mice. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
25 21708824 Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
26 15196800 Neural cell adhesion molecule (NCAM) null mice do not show a deficit in odour discrimination learning. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
27 20943062 Serum proteome of patients with systemic sclerosis: molecular analysis of expression and prevalence of haptoglobin alpha chain isoforms. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
28 17337466 Neural cell adhesion molecule expression on renal interstitial cells. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
29 8075973 Complementary DNA sequence encoding the major neural cell adhesion molecule isoform in a human small cell lung cancer cell line. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
30 11820619 Significance of cell adhesion molecules, CD56/NCAM in particular, in human tumor growth and spreading. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
31 12792358 Iron, haptoglobin phenotype, and HIV-1 viral load: a cross-sectional study among pregnant Zimbabwean women. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
32 20187302 Developmental tumourigenesis: NCAM as a putative marker for the malignant renal stem/progenitor cell population. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
33 3519135 Expression of cloned human haptoglobin and alpha 1-antitrypsin complementary DNAs in Saccharomyces cerevisiae. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
34 19210891 Haptoglobin phenotypes in systemic sclerosis. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
35 9352226 Biological functions of haptoglobin--new pieces to an old puzzle. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
36 23457771 Increased plasma zonulin in patients with sepsis. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
37 11876771 Regulation of acetylcholine release by muscarinic receptors at the mouse neuromuscular junction depends on the activity of acetylcholinesterase. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
38 1676488 A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
39 17962599 Haptoglobin 2-2 genotype determines chronic vasospasm after experimental subarachnoid hemorrhage. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
40 2887295 Human muscle neural cell adhesion molecule (N-CAM): identification of a muscle-specific sequence in the extracellular domain. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
41 3684567 Analysis of cDNA clones that code for the transmembrane forms of the mouse neural cell adhesion molecule (NCAM) and are generated by alternative RNA splicing. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
42 26097548 Role of cd56 and e-cadherin expression in the differential diagnosis of papillary thyroid carcinoma and suspected follicular-patterned lesions of the thyroid: the prognostic importance of e-cadherin. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
43 12699694 Expression and characterization of human bifunctional peptidylglycine alpha-amidating monooxygenase. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
44 15866595 Haptoglobin beta chain isoforms in the plasma and peritoneal fluid of women with endometriosis. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
45 25769453 Changed expression and function of P-gp in peripheral blood CD56 + cells predicting chemoresistance in non-Hodgkin lymphoma patients. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
46 27157273 Dysregulation of regulatory CD56(bright) NK cells/T cells interactions in multiple sclerosis. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
47 15246157 A Wilms tumor cell line, HFWT, can greatly stimulate proliferation of CD56+ human natural killer cells and their novel precursors in blood mononuclear cells. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
48 19137022 Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
49 30050033 Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
50 24613938 Genetic factors associated with serum haptoglobin level in a Japanese population. Pubmed 1.833E-4 4.734E-4 3.784E-3
3.044E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 147 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ST8SIA2 ST8SIA2 interactions 1.186E-3 3.505E-2
1.953E-1
1.743E-1
 1 3
2 int:JPH2 JPH2 interactions 1.581E-3 3.505E-2
1.953E-1
2.324E-1
 1 4
3 int:C1RL C1RL interactions 1.976E-3 3.505E-2
1.953E-1
2.904E-1
 1 5
4 int:UHMK1 UHMK1 interactions 1.976E-3 3.505E-2
1.953E-1
2.904E-1
 1 5
5 int:CD163 CD163 interactions 2.370E-3 3.505E-2
1.953E-1
3.485E-1
 1 6
6 int:TEX15 TEX15 interactions 2.370E-3 3.505E-2
1.953E-1
3.485E-1
 1 6
7 int:SIGLEC9 SIGLEC9 interactions 2.370E-3 3.505E-2
1.953E-1
3.485E-1
 1 6
8 int:GFRA1 GFRA1 interactions 3.160E-3 3.505E-2
1.953E-1
4.645E-1
 1 8
9 int:ACHE ACHE interactions 3.554E-3 3.505E-2
1.953E-1
5.224E-1
 1 9
10 int:SERPINA6 SERPINA6 interactions 3.948E-3 3.505E-2
1.953E-1
5.804E-1
 1 10
11 int:MIXL1 MIXL1 interactions 4.342E-3 3.505E-2
1.953E-1
6.383E-1
 1 11
12 int:SP7 SP7 interactions 4.342E-3 3.505E-2
1.953E-1
6.383E-1
 1 11
13 int:ISG20 ISG20 interactions 4.342E-3 3.505E-2
1.953E-1
6.383E-1
 1 11
14 int:TEKT1 TEKT1 interactions 4.342E-3 3.505E-2
1.953E-1
6.383E-1
 1 11
15 int:DLX1 DLX1 interactions 4.736E-3 3.505E-2
1.953E-1
6.962E-1
 1 12
16 int:REEP1 REEP1 interactions 4.736E-3 3.505E-2
1.953E-1
6.962E-1
 1 12
17 int:CDX4 CDX4 interactions 4.736E-3 3.505E-2
1.953E-1
6.962E-1
 1 12
18 int:BARX1 BARX1 interactions 4.736E-3 3.505E-2
1.953E-1
6.962E-1
 1 12
19 int:ST8SIA3 ST8SIA3 interactions 5.130E-3 3.505E-2
1.953E-1
7.541E-1
 1 13
20 int:NCAN NCAN interactions 5.130E-3 3.505E-2
1.953E-1
7.541E-1
 1 13
21 int:P3H2 P3H2 interactions 5.130E-3 3.505E-2
1.953E-1
7.541E-1
 1 13
22 int:OPCML OPCML interactions 5.917E-3 3.505E-2
1.953E-1
8.698E-1
 1 15
23 int:MUSK MUSK interactions 5.917E-3 3.505E-2
1.953E-1
8.698E-1
 1 15
24 int:GDNF GDNF interactions 6.704E-3 3.505E-2
1.953E-1
9.855E-1
 1 17
25 int:DLX2 DLX2 interactions 7.097E-3 3.505E-2
1.953E-1
1.000E0
 1 18
26 int:ATP7B ATP7B interactions 7.097E-3 3.505E-2
1.953E-1
1.000E0
 1 18
27 int:COLQ COLQ interactions 7.490E-3 3.505E-2
1.953E-1
1.000E0
 1 19
28 int:HOXB13 HOXB13 interactions 7.883E-3 3.505E-2
1.953E-1
1.000E0
 1 20
29 int:BDNF BDNF interactions 7.883E-3 3.505E-2
1.953E-1
1.000E0
 1 20
30 int:CHD2 CHD2 interactions 7.883E-3 3.505E-2
1.953E-1
1.000E0
 1 20
31 int:P3H3 P3H3 interactions 8.276E-3 3.505E-2
1.953E-1
1.000E0
 1 21
32 int:PAM PAM interactions 8.668E-3 3.505E-2
1.953E-1
1.000E0
 1 22
33 int:LAMC3 LAMC3 interactions 8.668E-3 3.505E-2
1.953E-1
1.000E0
 1 22
34 int:SLC30A4 SLC30A4 interactions 9.061E-3 3.505E-2
1.953E-1
1.000E0
 1 23
35 int:CD22 CD22 interactions 9.061E-3 3.505E-2
1.953E-1
1.000E0
 1 23
36 int:ITGAM ITGAM interactions 9.061E-3 3.505E-2
1.953E-1
1.000E0
 1 23
37 int:TBX21 TBX21 interactions 9.061E-3 3.505E-2
1.953E-1
1.000E0
 1 23
38 int:P3H4 P3H4 interactions 9.061E-3 3.505E-2
1.953E-1
1.000E0
 1 23
39 int:ART3 ART3 interactions 9.845E-3 3.618E-2
2.016E-1
1.000E0
 1 25
40 int:DPEP2 DPEP2 interactions 9.845E-3 3.618E-2
2.016E-1
1.000E0
 1 25
41 int:SPTB SPTB interactions 1.102E-2 3.902E-2
2.174E-1
1.000E0
 1 28
42 int:BCHE BCHE interactions 1.141E-2 3.902E-2
2.174E-1
1.000E0
 1 29
43 int:GDPD1 GDPD1 interactions 1.141E-2 3.902E-2
2.174E-1
1.000E0
 1 29
44 int:B3GNT2 B3GNT2 interactions 1.220E-2 4.065E-2
2.265E-1
1.000E0
 1 31
45 int:TRIM68 TRIM68 interactions 1.376E-2 4.065E-2
2.265E-1
1.000E0
 1 35
46 int:HP HP interactions 1.376E-2 4.065E-2
2.265E-1
1.000E0
 1 35
47 int:ADAMTS4 ADAMTS4 interactions 1.415E-2 4.065E-2
2.265E-1
1.000E0
 1 36
48 int:BRF2 BRF2 interactions 1.415E-2 4.065E-2
2.265E-1
1.000E0
 1 36
49 int:CYP2S1 CYP2S1 interactions 1.493E-2 4.065E-2
2.265E-1
1.000E0
 1 38
50 int:ICE2 ICE2 interactions 1.493E-2 4.065E-2
2.265E-1
1.000E0
 1 38
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5q14-q21 5q14-q21 2.020E-4 1.414E-3 3.666E-3 1.414E-3 1 1
2 2q32 2q32 2.824E-3 6.000E-3 1.556E-2 1.977E-2 1 14
3 15q26 15q26 3.227E-3 6.000E-3 1.556E-2 2.259E-2 1 16
4 3p25 3p25 3.429E-3 6.000E-3 1.556E-2 2.400E-2 1 17
5 16q22.2 16q22.2 4.636E-3 6.491E-3 1.683E-2 3.245E-2 1 23
6 11q23.1 11q23.1 7.650E-3 8.925E-3 2.314E-2
5.355E-2
 1 38
7 20q13.12 20q13.12 1.405E-2 1.405E-2 3.644E-2
9.837E-2
 1 70
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 199 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$GR Q6 V$GR Q6 7.863E-6 1.565E-3 9.190E-3 1.565E-3 4 217
2 V$POU6F1 01 V$POU6F1 01 2.544E-4 1.385E-2
8.134E-2
5.063E-2
 3 194
3 V$TCF4 Q5 V$TCF4 Q5 2.784E-4 1.385E-2
8.134E-2
5.540E-2
 3 200
4 V$OCT1 04 V$OCT1 04 2.784E-4 1.385E-2
8.134E-2
5.540E-2
 3 200

12: Gene Family [Display Chart] 4 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1167 INO80 complex |DNA helicases genenames.org 3.733E-3 2.240E-2
5.487E-2
 2.240E-2 1 17
2 1179 Apolipoproteins|Sushi domain containing genenames.org 1.247E-2 2.930E-2
7.179E-2
7.484E-2
 1 57
3 519 NKL subclass homeoboxes and pseudogenes genenames.org 1.465E-2 2.930E-2
7.179E-2
8.790E-2
 1 67
4 555 Receptor Tyrosine Kinases|Fibronectin type III domain containing|V-set domain containing|Immunoglobulin like domain containing genenames.org 3.472E-2 4.192E-2
1.027E-1
2.083E-1
 1 160
5 593 Fibronectin type III domain containing|I-set domain containing|Immunoglobulin like domain containing genenames.org 3.493E-2 4.192E-2
1.027E-1
2.096E-1
 1 161

13: Coexpression [Display Chart] 7 input genes in category / 747 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2310 Genes down-regulated by MYC [GeneID=4609], according to the MYC Target Gene Database. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.378E-5 2.160E-2
1.554E-1
 3.270E-2 3 253
2 M8155 Genes down-regulated during pubertal mammary gland development between weeks 3 and 4. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.783E-5 2.160E-2
1.554E-1
 4.320E-2 2 39
3 M4872 Genes up-regulated in mature plasma cells compared with plasmablastic B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.667E-4 4.151E-2
2.986E-1
1.245E-1
 3 397
4 15845616-SuppTable3 Mouse Uterine Jeong05 634genes GeneSigDB 2.955E-4 4.198E-2
3.020E-1
2.207E-1
 3 482
5 M2747 Genes down-regulated in MCF10A cells (breast cancer) upon knockdown of BRCA1 [Gene ID=672] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 7.590E-4 4.198E-2
3.020E-1
5.670E-1
 2 141
6 20502458-TableS6b Human Sarcoma Missiaglia10 212genes GeneSigDB 8.024E-4 4.198E-2
3.020E-1
5.994E-1
 2 145
7 M8992 Genes down-regulated in CD4 [GeneID=920] T cells treated with rosiglitazone [PubChem=77999] and over-expressing: FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943] and PPARg2 isoform of PPARG [GeneID=5468]. MSigDB C7: Immunologic Signatures (v6.0) 9.635E-4 4.198E-2
3.020E-1
7.197E-1
 2 159
8 M5194 Genes down-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to L. major. MSigDB C7: Immunologic Signatures (v6.0) 1.473E-3 4.198E-2
3.020E-1
1.000E0
 2 197
9 M7562 Genes up-regulated in CD11b+ cells from BALB/c mice: spleen versus bone marrow. MSigDB C7: Immunologic Signatures (v6.0) 1.488E-3 4.198E-2
3.020E-1
1.000E0
 2 198
10 M5564 Genes up-regulated in comparison of basophils versus Th1 cells. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 4.198E-2
3.020E-1
1.000E0
 2 199
11 M5548 Genes down-regulated in comparison of B cells versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 4.198E-2
3.020E-1
1.000E0
 2 199
12 M8408 Genes down-regulated in dendritic cells: CD8+ spleen versus brain. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 4.198E-2
3.020E-1
1.000E0
 2 199
13 M3587 Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
14 M5480 Genes down-regulated in comparison of dendritic cells (DC) versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
15 M9689 Genes up-regulated in CD4 [GeneID=920] T helper cells Th0: 10h versus 30h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
16 M5774 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMCs from patients with type 1 diabetes at the time of diagnosis. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
17 M6459 Genes up-regulated in T cells: CD4 [GeneID=920] versus CD8A CD8B [GeneID=925;926]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
18 M6263 Genes down-regulated in CD8 T cells: healthy versus CLL (chronic lymphocytic leukemia). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
19 M6462 Genes up-regulated in CD4 [GeneID=920] T cells versus B2 B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
20 M5806 Genes down-regulated in comparison of untreated macrophages at 4 h versus those treated with LPS (TLR4 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
21 M3227 Genes down-regulated in regulatory T cell (Treg) treated with retinoic acid (tretinoin) [PubChem=444795] versus conventional T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
22 M3593 Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 24 h after stimulation with antigen-B7-1. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
23 M4899 Genes down-regulated in comparison of primary splenic B cells from wild type mice versus those from BTK [GeneID=695] knockout mice. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
24 M9392 Genes up-regulated in day 7 plasma cells versus day 40 germinal center B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
25 M8698 Genes up-regulated in bone marrow-derived macrophages: heterozygous versus homozygous knockout of MLL4 [GeneID=9757]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
26 M4037 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
27 M3111 Genes up-regulated in comparison of effector memory T cells versus central memory T cells from peripheral blood mononuclear cells (PBMC). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 4.198E-2
3.020E-1
1.000E0
 2 200
28 17390049-Table2 Human Colon Bandres07 8genes GeneSigDB 1.814E-3 4.840E-2
3.482E-1
1.000E0
 1 6
Show 23 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 987 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 5 input genes in category / 66 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 7 input genes in category / 245 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-483-3p.1:TargetScan hsa-miR-483-3p.1 TargetScan 3.887E-5 9.522E-3
5.790E-2
 9.522E-3 2 99
2 hsa-miR-595:PITA hsa-miR-595:PITA TOP PITA 1.867E-4 1.069E-2
6.500E-2
 4.575E-2 2 217
3 hsa-miR-329-3p:TargetScan hsa-miR-329-3p TargetScan 2.657E-4 1.069E-2
6.500E-2
6.510E-2
 2 259
4 hsa-miR-362-3p:TargetScan hsa-miR-362-3p TargetScan 2.657E-4 1.069E-2
6.500E-2
6.510E-2
 2 259
5 hsa-miR-150-5p:TargetScan hsa-miR-150-5p TargetScan 2.802E-4 1.069E-2
6.500E-2
6.865E-2
 2 266
6 hsa-miR-376c:PITA hsa-miR-376c:PITA TOP PITA 3.513E-4 1.069E-2
6.500E-2
8.607E-2
 2 298
7 hsa-miR-1324:PITA hsa-miR-1324:PITA TOP PITA 4.251E-4 1.069E-2
6.500E-2
1.042E-1
 2 328
8 hsa-miR-421:TargetScan hsa-miR-421 TargetScan 4.355E-4 1.069E-2
6.500E-2
1.067E-1
 2 332
9 hsa-miR-361-3p:mirSVR highEffct hsa-miR-361-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.728E-4 1.069E-2
6.500E-2
1.158E-1
 2 346
10 hsa-miR-212-3p:TargetScan hsa-miR-212-3p TargetScan 5.087E-4 1.069E-2
6.500E-2
1.246E-1
 2 359
11 hsa-miR-132-3p:TargetScan hsa-miR-132-3p TargetScan 5.087E-4 1.069E-2
6.500E-2
1.246E-1
 2 359
12 hsa-miR-183-5p.1:TargetScan hsa-miR-183-5p.1 TargetScan 5.344E-4 1.069E-2
6.500E-2
1.309E-1
 2 368
13 AATGTGA,MIR-23B:MSigDB AATGTGA,MIR-23B:MSigDB MSigDB 6.181E-4 1.069E-2
6.500E-2
1.514E-1
 2 396
14 AATGTGA,MIR-23A:MSigDB AATGTGA,MIR-23A:MSigDB MSigDB 6.181E-4 1.069E-2
6.500E-2
1.514E-1
 2 396
15 hsa-miR-142-3p.2:TargetScan hsa-miR-142-3p.2 TargetScan 7.244E-4 1.069E-2
6.500E-2
1.775E-1
 2 429
16 hsa-miR-184:mirSVR lowEffct hsa-miR-184:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 7.651E-4 1.069E-2
6.500E-2
1.875E-1
 2 441
17 hsa-miR-1914:mirSVR highEffct hsa-miR-1914:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.929E-4 1.069E-2
6.500E-2
1.943E-1
 2 449
18 hsa-miR-1306:mirSVR lowEffct hsa-miR-1306:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.426E-4 1.069E-2
6.500E-2
2.064E-1
 2 463
19 hsa-miR-1289:mirSVR highEffct hsa-miR-1289:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.680E-4 1.069E-2
6.500E-2
2.127E-1
 2 470
20 hsa-miR-140-3p.1:TargetScan hsa-miR-140-3p.1 TargetScan 9.050E-4 1.069E-2
6.500E-2
2.217E-1
 2 480
21 hsa-miR-181c*:mirSVR lowEffct hsa-miR-181c*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.162E-4 1.069E-2
6.500E-2
2.245E-1
 2 483
22 hsa-miR-450a-5p:Functional MTI Functional MTI miRTarbase 1.646E-3 1.754E-2
1.066E-1
4.033E-1
 1 17
23 hsa-miR-572:PITA hsa-miR-572:PITA TOP PITA 1.646E-3 1.754E-2
1.066E-1
4.033E-1
 1 17
24 hsa-miR-1292:PITA hsa-miR-1292:PITA TOP PITA 1.743E-3 1.779E-2
1.082E-1
4.270E-1
 1 18
25 GTCAACC,MIR-380-5P:MSigDB GTCAACC,MIR-380-5P:MSigDB MSigDB 2.033E-3 1.993E-2
1.212E-1
4.981E-1
 1 21
26 hsa-miR-210:PITA hsa-miR-210:PITA TOP PITA 3.097E-3 2.918E-2
1.774E-1
7.587E-1
 1 32
27 hsa-miR-1298:PITA hsa-miR-1298:PITA TOP PITA 3.290E-3 2.985E-2
1.815E-1
8.061E-1
 1 34
28 CTCTATG,MIR-368:MSigDB CTCTATG,MIR-368:MSigDB MSigDB 3.676E-3 3.217E-2
1.956E-1
9.007E-1
 1 38
29 hsa-miR-1295:mirSVR highEffct hsa-miR-1295:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.221E-3 4.334E-2
2.636E-1
1.000E0
 1 54
30 hsa-miR-4771:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.510E-3 4.334E-2
2.636E-1
1.000E0
 1 57
31 hsa-miR-488-5p:Functional MTI Functional MTI miRTarbase 5.703E-3 4.334E-2
2.636E-1
1.000E0
 1 59
32 CTAGGAA,MIR-384:MSigDB CTAGGAA,MIR-384:MSigDB MSigDB 5.800E-3 4.334E-2
2.636E-1
1.000E0
 1 60
33 hsa-miR-615-5p:PITA hsa-miR-615-5p:PITA TOP PITA 6.378E-3 4.334E-2
2.636E-1
1.000E0
 1 66
34 hsa-miR-6730-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.571E-3 4.334E-2
2.636E-1
1.000E0
 1 68
35 hsa-miR-1273h-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.667E-3 4.334E-2
2.636E-1
1.000E0
 1 69
36 ACAACTT,MIR-382:MSigDB ACAACTT,MIR-382:MSigDB MSigDB 6.667E-3 4.334E-2
2.636E-1
1.000E0
 1 69
37 hsa-miR-1539:mirSVR highEffct hsa-miR-1539:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.763E-3 4.334E-2
2.636E-1
1.000E0
 1 70
38 hsa-miR-1247:mirSVR highEffct hsa-miR-1247:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.052E-3 4.334E-2
2.636E-1
1.000E0
 1 73
39 hsa-miR-611:mirSVR highEffct hsa-miR-611:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.630E-3 4.334E-2
2.636E-1
1.000E0
 1 79
40 hsa-miR-369-5p:mirSVR highEffct hsa-miR-369-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.823E-3 4.334E-2
2.636E-1
1.000E0
 1 81
41 hsa-miR-3166:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.111E-3 4.334E-2
2.636E-1
1.000E0
 1 84
42 hsa-miR-572:mirSVR highEffct hsa-miR-572:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.400E-3 4.334E-2
2.636E-1
1.000E0
 1 87
43 hsa-miR-1181:mirSVR lowEffct hsa-miR-1181:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.881E-3 4.334E-2
2.636E-1
1.000E0
 1 92
44 hsa-miR-3131:mirSVR highEffct hsa-miR-3131:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.650E-3 4.334E-2
2.636E-1
1.000E0
 1 100
45 hsa-miR-1205:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.746E-3 4.334E-2
2.636E-1
1.000E0
 1 101
46 hsa-miR-1471:mirSVR lowEffct hsa-miR-1471:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.746E-3 4.334E-2
2.636E-1
1.000E0
 1 101
47 hsa-miR-3158-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.842E-3 4.334E-2
2.636E-1
1.000E0
 1 102
48 GGTGTGT,MIR-329:MSigDB GGTGTGT,MIR-329:MSigDB MSigDB 9.938E-3 4.334E-2
2.636E-1
1.000E0
 1 103
49 hsa-miR-122:PITA hsa-miR-122:PITA TOP PITA 1.013E-2 4.334E-2
2.636E-1
1.000E0
 1 105
50 hsa-miR-574-5p:PITA hsa-miR-574-5p:PITA TOP PITA 1.023E-2 4.334E-2
2.636E-1
1.000E0
 1 106
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 1368 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000448889 AC1L9MGN Stitch 4.232E-5 2.619E-2
2.042E-1
5.789E-2
 2 33
2 CID005311023 BIBP3226 Stitch 7.569E-5 2.619E-2
2.042E-1
1.036E-1
 2 44
3 CID000447618 1 Ni Stitch 2.330E-4 2.619E-2
2.042E-1
3.187E-1
 2 77
4 CID003342293 AC1MOE8Y Stitch 2.391E-4 2.619E-2
2.042E-1
3.271E-1
 2 78
5 CID000021321 Benzadox Stitch 3.065E-4 2.619E-2
2.042E-1
4.192E-1
 1 1
6 CID000101928 o160 Stitch 3.065E-4 2.619E-2
2.042E-1
4.192E-1
 1 1
7 ctd:C034163 gallium chloride CTD 3.065E-4 2.619E-2
2.042E-1
4.192E-1
 1 1
8 DB04150 Threonine Derivative Drug Bank 3.065E-4 2.619E-2
2.042E-1
4.192E-1
 1 1
9 ctd:C025302 ferric nitrate CTD 3.065E-4 2.619E-2
2.042E-1
4.192E-1
 1 1
10 ctd:C066029 alpha-hydroxybenzoylglycine CTD 3.065E-4 2.619E-2
2.042E-1
4.192E-1
 1 1
11 ctd:C071927 perlecan CTD 3.065E-4 2.619E-2
2.042E-1
4.192E-1
 1 1
12 DB02598 N-Alpha-Acetyl-3,5-Diiodotyrosylglycine Drug Bank 3.065E-4 2.619E-2
2.042E-1
4.192E-1
 1 1
13 ctd:C031835 potassium ferrocyanide CTD 3.065E-4 2.619E-2
2.042E-1
4.192E-1
 1 1
14 CID000447701 IYG Stitch 6.129E-4 2.619E-2
2.042E-1
8.384E-1
 1 2
15 CID010888709 tris[2-(methylamino)ethyl]amine Stitch 6.129E-4 2.619E-2
2.042E-1
8.384E-1
 1 2
16 CID000150783 2-isocyanopropane Stitch 6.129E-4 2.619E-2
2.042E-1
8.384E-1
 1 2
17 CID000016821 gamma-dodecalactone Stitch 6.129E-4 2.619E-2
2.042E-1
8.384E-1
 1 2
18 CID000063031 Prothanon Stitch 6.129E-4 2.619E-2
2.042E-1
8.384E-1
 1 2
19 CID000014773 barium peroxide Stitch 6.129E-4 2.619E-2
2.042E-1
8.384E-1
 1 2
20 CID000042631 cysteine hydrazide Stitch 6.129E-4 2.619E-2
2.042E-1
8.384E-1
 1 2
21 ctd:C084615 alclofenac CTD 9.192E-4 2.619E-2
2.042E-1
1.000E0
 1 3
22 CID000151743 NSC 250427 Stitch 9.192E-4 2.619E-2
2.042E-1
1.000E0
 1 3
23 CID000007021 AC1L1NTP Stitch 9.192E-4 2.619E-2
2.042E-1
1.000E0
 1 3
24 CID000667473 AC1LDI5R Stitch 9.192E-4 2.619E-2
2.042E-1
1.000E0
 1 3
25 ctd:D013774 Tetranitromethane CTD 9.192E-4 2.619E-2
2.042E-1
1.000E0
 1 3
26 CID000052795 NSC-61590 Stitch 9.192E-4 2.619E-2
2.042E-1
1.000E0
 1 3
27 CID005474491 Direct Brown 2 Stitch 9.192E-4 2.619E-2
2.042E-1
1.000E0
 1 3
28 CID000072877 gentisamide Stitch 9.192E-4 2.619E-2
2.042E-1
1.000E0
 1 3
29 CID000009883 HFPO Stitch 9.192E-4 2.619E-2
2.042E-1
1.000E0
 1 3
30 CID000161488 gentisuric acid Stitch 9.192E-4 2.619E-2
2.042E-1
1.000E0
 1 3
31 CID000443039 isoimide Stitch 9.192E-4 2.619E-2
2.042E-1
1.000E0
 1 3
32 CID003908947 AC1MZZID Stitch 9.192E-4 2.619E-2
2.042E-1
1.000E0
 1 3
33 ctd:D002185 Cannabidiol CTD 1.026E-3 2.619E-2
2.042E-1
1.000E0
 2 162
34 CID000007898 2-cyanoacetamide Stitch 1.026E-3 2.619E-2
2.042E-1
1.000E0
 2 162
35 CID000000760 glyoxylate Stitch 1.209E-3 2.619E-2
2.042E-1
1.000E0
 2 176
36 CID000098799 Sw 2 Stitch 1.225E-3 2.619E-2
2.042E-1
1.000E0
 1 4
37 CID000344857 NSC401987 Stitch 1.225E-3 2.619E-2
2.042E-1
1.000E0
 1 4
38 CID000445613 AC1L9IAC Stitch 1.225E-3 2.619E-2
2.042E-1
1.000E0
 1 4
39 CID000061330 dichlorosilylene Stitch 1.225E-3 2.619E-2
2.042E-1
1.000E0
 1 4
40 CID003025913 4-hydroxy-1-phenyl-1-octanone Stitch 1.225E-3 2.619E-2
2.042E-1
1.000E0
 1 4
41 CID014017685 3beta,5beta-ketotriol Stitch 1.225E-3 2.619E-2
2.042E-1
1.000E0
 1 4
42 CID003082501 AC1MIYYS Stitch 1.225E-3 2.619E-2
2.042E-1
1.000E0
 1 4
43 CID003067906 DL-10 Stitch 1.225E-3 2.619E-2
2.042E-1
1.000E0
 1 4
44 CID000151229 aminohydroxyacetic acid Stitch 1.225E-3 2.619E-2
2.042E-1
1.000E0
 1 4
45 2474 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.363E-3 2.619E-2
2.042E-1
1.000E0
 2 187
46 2137 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.421E-3 2.619E-2
2.042E-1
1.000E0
 2 191
47 3114 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.436E-3 2.619E-2
2.042E-1
1.000E0
 2 192
48 201 UP 15d-PGJ2; Up 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Up 1.451E-3 2.619E-2
2.042E-1
1.000E0
 2 193
49 2477 DN Etifenin [63245-28-3]; Down 200; 12.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.465E-3 2.619E-2
2.042E-1
1.000E0
 2 194
50 3078 UP Urapidil hydrochloride [64887-14-5]; Up 200; 9.4uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.480E-3 2.619E-2
2.042E-1
1.000E0
 2 195
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 413 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0036202 Sarcoidosis DisGeNET Curated 6.726E-5 1.250E-2
8.251E-2
 2.778E-2 3 205
2 C2919945 Cavernous Hemangioma of Brain DisGeNET Curated 2.264E-4 1.250E-2
8.251E-2
9.352E-2
 2 54
3 C1384514 Conn Syndrome DisGeNET BeFree 2.524E-4 1.250E-2
8.251E-2
1.042E-1
 2 57
4 C0519037 Lymphoma of colon DisGeNET BeFree 4.320E-4 1.250E-2
8.251E-2
1.784E-1
 1 1
5 C3809278 EPILEPTIC ENCEPHALOPATHY, CHILDHOOD-ONSET DisGeNET Curated 4.320E-4 1.250E-2
8.251E-2
1.784E-1
 1 1
6 cv:CN178848 Epileptic encephalopathy, childhood-onset Clinical Variations 4.320E-4 1.250E-2
8.251E-2
1.784E-1
 1 1
7 OMIN:603034 ENDPLATE ACETYLCHOLINESTERASE DEFICIENCY; EAD OMIM 4.320E-4 1.250E-2
8.251E-2
1.784E-1
 1 1
8 C0679360 Foodborne Disease DisGeNET Curated 4.320E-4 1.250E-2
8.251E-2
1.784E-1
 1 1
9 C3151264 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 17 DisGeNET Curated 4.320E-4 1.250E-2
8.251E-2
1.784E-1
 1 1
10 C0241831 Cerebral salt-wasting syndrome DisGeNET BeFree 4.320E-4 1.250E-2
8.251E-2
1.784E-1
 1 1
11 cv:C1864233 Endplate acetylcholinesterase deficiency Clinical Variations 4.320E-4 1.250E-2
8.251E-2
1.784E-1
 1 1
12 cv:C3279786 Anhaptoglobinemia Clinical Variations 4.320E-4 1.250E-2
8.251E-2
1.784E-1
 1 1
13 C0312854 Extravascular Hemolysis DisGeNET BeFree 4.320E-4 1.250E-2
8.251E-2
1.784E-1
 1 1
14 cv:C3151264 Familial hypertrophic cardiomyopathy 17 Clinical Variations 4.320E-4 1.250E-2
8.251E-2
1.784E-1
 1 1
15 C0035412 Rhabdomyosarcoma DisGeNET Curated 4.539E-4 1.250E-2
8.251E-2
1.875E-1
 3 391
16 C1864238 Prolonged miniature endplate currents (MEPC) DisGeNET Curated 8.638E-4 1.486E-2
9.813E-2
3.567E-1
 1 2
17 C0234972 Convulsive disorder DisGeNET BeFree 8.638E-4 1.486E-2
9.813E-2
3.567E-1
 1 2
18 C3272525 Monomorphic CD56+ Intestinal T-Cell Lymphoma DisGeNET BeFree 8.638E-4 1.486E-2
9.813E-2
3.567E-1
 1 2
19 C2350168 Polymorphic Reticulosis DisGeNET BeFree 8.638E-4 1.486E-2
9.813E-2
3.567E-1
 1 2
20 C4023471 EEG with abnormally slow frequencies DisGeNET Curated 8.638E-4 1.486E-2
9.813E-2
3.567E-1
 1 2
21 C0036474 Scurvy DisGeNET Curated 8.638E-4 1.486E-2
9.813E-2
3.567E-1
 1 2
22 C0852036 Pregnancy associated hypertension DisGeNET Curated 8.638E-4 1.486E-2
9.813E-2
3.567E-1
 1 2
23 C0438414 Myoclonic Encephalopathy DisGeNET BeFree 8.638E-4 1.486E-2
9.813E-2
3.567E-1
 1 2
24 C3279786 ANHAPTOGLOBINEMIA DisGeNET Curated 8.638E-4 1.486E-2
9.813E-2
3.567E-1
 1 2
25 C0566602 Primary sclerosing cholangitis DisGeNET Curated 1.267E-3 1.621E-2
1.070E-1
5.232E-1
 2 128
26 C0017416 Genital Neoplasms, Female DisGeNET Curated 1.295E-3 1.621E-2
1.070E-1
5.350E-1
 1 3
27 C0085397 Pasteurellaceae Infections DisGeNET Curated 1.295E-3 1.621E-2
1.070E-1
5.350E-1
 1 3
28 C0393720 Reflex Epilepsy, Photosensitive DisGeNET BeFree 1.295E-3 1.621E-2
1.070E-1
5.350E-1
 1 3
29 C2931868 Catalase deficiency DisGeNET BeFree 1.295E-3 1.621E-2
1.070E-1
5.350E-1
 1 3
30 C0268419 Acatalasia DisGeNET Curated 1.295E-3 1.621E-2
1.070E-1
5.350E-1
 1 3
31 C4023684 EEG with spike-wave complexes (>3.5 Hz) DisGeNET Curated 1.295E-3 1.621E-2
1.070E-1
5.350E-1
 1 3
32 C0019114 Hemosiderosis DisGeNET BeFree 1.295E-3 1.621E-2
1.070E-1
5.350E-1
 1 3
33 C4020765 EEG with 3-4-Hz spike waves DisGeNET Curated 1.295E-3 1.621E-2
1.070E-1
5.350E-1
 1 3
34 C0393702 Myoclonic Astatic Epilepsy DisGeNET Curated 1.727E-3 1.829E-2
1.207E-1
7.132E-1
 1 4
35 C4025615 Decreased size of nerve terminals DisGeNET Curated 1.727E-3 1.829E-2
1.207E-1
7.132E-1
 1 4
36 C4020841 EMG: decrement at repetitive stimulation DisGeNET Curated 1.727E-3 1.829E-2
1.207E-1
7.132E-1
 1 4
37 C4021728 EMG: decremental response of compound muscle action potential to repetitive nerve stimulation DisGeNET Curated 1.727E-3 1.829E-2
1.207E-1
7.132E-1
 1 4
38 C0003969 Ascorbic Acid Deficiency DisGeNET BeFree 1.727E-3 1.829E-2
1.207E-1
7.132E-1
 1 4
39 C2025392 Polar cataract DisGeNET Curated 1.727E-3 1.829E-2
1.207E-1
7.132E-1
 1 4
40 C0595948 Atypical absence seizure DisGeNET Curated 2.158E-3 1.970E-2
1.300E-1
8.913E-1
 1 5
41 C0342257 Complications of Diabetes Mellitus DisGeNET Curated 2.158E-3 1.970E-2
1.300E-1
8.913E-1
 1 5
42 C4023479 EEG with focal sharp slow waves DisGeNET Curated 2.158E-3 1.970E-2
1.300E-1
8.913E-1
 1 5
43 C0041227 Trypanosomiasis DisGeNET BeFree 2.158E-3 1.970E-2
1.300E-1
8.913E-1
 1 5
44 C0741975 carotid disease DisGeNET BeFree 2.158E-3 1.970E-2
1.300E-1
8.913E-1
 1 5
45 C0558916 Nasal and nasal-type NK/T-cell lymphoma DisGeNET BeFree 2.158E-3 1.970E-2
1.300E-1
8.913E-1
 1 5
46 C0026896 Myasthenia Gravis DisGeNET Curated 2.194E-3 1.970E-2
1.300E-1
9.060E-1
 2 169
47 C0522624 Subcutaneous panniculitis-like T-cell lymphoma DisGeNET BeFree 2.589E-3 2.182E-2
1.441E-1
1.000E0
 1 6
48 C0019054 Hemolysis (disorder) DisGeNET Curated 2.589E-3 2.182E-2
1.441E-1
1.000E0
 1 6
49 C1864233 ENDPLATE ACETYLCHOLINESTERASE DEFICIENCY (disorder) DisGeNET Curated 2.589E-3 2.182E-2
1.441E-1
1.000E0
 1 6
50 C0013362 Dysarthria DisGeNET Curated 2.937E-3 2.310E-2
1.525E-1
1.000E0
 2 196
Show 45 more annotations