Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc27_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 44 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016175 superoxide-generating NADPH oxidase activity 2.113E-24 9.297E-23 4.065E-22 9.297E-23 7 11
2 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1.245E-22 2.740E-21 1.198E-20 5.479E-21 7 17
3 GO:0016651 oxidoreductase activity, acting on NAD(P)H 1.269E-16 1.861E-15 8.136E-15 5.582E-15 7 103
4 GO:0009055 electron transfer activity 4.890E-8 5.379E-7 2.352E-6 2.152E-6 4 116
5 GO:0020037 heme binding 7.987E-8 7.028E-7 3.073E-6 3.514E-6 4 131
6 GO:0046906 tetrapyrrole binding 1.044E-7 7.654E-7 3.347E-6 4.592E-6 4 140
7 GO:0050662 coenzyme binding 3.711E-7 2.333E-6 1.020E-5 1.633E-5 4 192
8 GO:0015252 proton channel activity 1.206E-6 6.630E-6 2.899E-5 5.304E-5 2 5
9 GO:0048037 cofactor binding 1.605E-6 7.849E-6 3.432E-5 7.064E-5 4 277
10 GO:0050660 flavin adenine dinucleotide binding 2.246E-6 9.881E-6 4.321E-5 9.881E-5 3 76
11 GO:0043883 malolactic enzyme activity 5.580E-5 1.636E-4 7.156E-4 2.455E-3 2 31
12 GO:0043738 reduced coenzyme F420 dehydrogenase activity 5.580E-5 1.636E-4 7.156E-4 2.455E-3 2 31
13 GO:0052693 epoxyqueuosine reductase activity 5.580E-5 1.636E-4 7.156E-4 2.455E-3 2 31
14 GO:0008748 N-ethylmaleimide reductase activity 5.580E-5 1.636E-4 7.156E-4 2.455E-3 2 31
15 GO:0043826 sulfur oxygenase reductase activity 5.580E-5 1.636E-4 7.156E-4 2.455E-3 2 31
16 GO:0043914 NADPH:sulfur oxidoreductase activity 5.951E-5 1.636E-4 7.156E-4 2.618E-3 2 32
17 GO:0050661 NADP binding 1.349E-4 3.493E-4 1.527E-3 5.937E-3 2 48
18 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2.113E-4 5.165E-4 2.258E-3 9.297E-3 2 60
19 GO:0005216 ion channel activity 3.808E-4 8.820E-4 3.857E-3 1.676E-2 3 424
20 GO:0022838 substrate-specific channel activity 4.190E-4 9.217E-4 4.030E-3 1.843E-2 3 438
21 GO:0015267 channel activity 5.152E-4 1.037E-3 4.534E-3 2.267E-2 3 470
22 GO:0022803 passive transmembrane transporter activity 5.184E-4 1.037E-3 4.534E-3 2.281E-2 3 471
23 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 6.713E-4 1.284E-3 5.615E-3 2.954E-2 2 107
24 GO:0030171 voltage-gated proton channel activity 7.501E-4 1.375E-3 6.013E-3 3.300E-2 1 2
25 GO:0017124 SH3 domain binding 8.856E-4 1.559E-3 6.816E-3 3.897E-2 2 123
26 GO:0019826 oxygen sensor activity 1.125E-3 1.904E-3 8.325E-3 4.950E-2 1 3
27 GO:0022832 voltage-gated channel activity 2.271E-3 3.569E-3 1.561E-2
9.994E-2
 2 198
28 GO:0005244 voltage-gated ion channel activity 2.271E-3 3.569E-3 1.561E-2
9.994E-2
 2 198
29 GO:0016174 NAD(P)H oxidase activity 2.623E-3 3.980E-3 1.740E-2
1.154E-1
 1 7
30 GO:0005261 cation channel activity 5.330E-3 7.818E-3 3.418E-2
2.345E-1
 2 306
31 GO:0022836 gated channel activity 6.210E-3 8.815E-3 3.854E-2
2.733E-1
 2 331
32 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 8.225E-3 1.131E-2 4.945E-2
3.619E-1
 1 22
33 GO:0048365 Rac GTPase binding 1.565E-2 2.087E-2
9.125E-2
6.887E-1
 1 42
34 GO:0019825 oxygen binding 1.898E-2 2.456E-2
1.074E-1
8.350E-1
 1 51
35 GO:0072341 modified amino acid binding 2.743E-2 3.449E-2
1.508E-1
1.000E0
 1 74
36 GO:1902936 phosphatidylinositol bisphosphate binding 3.036E-2 3.711E-2
1.623E-1
1.000E0
 1 82
37 GO:0017048 Rho GTPase binding 3.219E-2 3.828E-2
1.674E-1
1.000E0
 1 87
Show 32 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 383 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042554 superoxide anion generation 7.690E-21 2.945E-18 1.922E-17 2.945E-18 7 28
2 GO:0006801 superoxide metabolic process 2.834E-18 5.426E-16 3.541E-15 1.085E-15 7 61
3 GO:0072593 reactive oxygen species metabolic process 1.007E-13 1.286E-11 8.393E-11 3.858E-11 7 262
4 GO:0045730 respiratory burst 2.503E-10 2.397E-8 1.564E-7 9.587E-8 4 32
5 GO:0042743 hydrogen peroxide metabolic process 1.599E-9 1.225E-7 7.996E-7 6.125E-7 4 50
6 GO:0000302 response to reactive oxygen species 8.958E-9 5.081E-7 3.316E-6 3.431E-6 5 252
7 GO:0050665 hydrogen peroxide biosynthetic process 9.286E-9 5.081E-7 3.316E-6 3.556E-6 3 13
8 GO:2000379 positive regulation of reactive oxygen species metabolic process 2.817E-8 1.349E-6 8.801E-6 1.079E-5 4 101
9 GO:0006979 response to oxidative stress 1.437E-7 6.117E-6 3.992E-5 5.505E-5 5 439
10 GO:2000377 regulation of reactive oxygen species metabolic process 2.700E-7 1.034E-5 6.749E-5 1.034E-4 4 177
11 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 1.342E-6 4.671E-5 3.049E-4 5.138E-4 3 64
12 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 1.613E-6 4.967E-5 3.241E-4 6.177E-4 3 68
13 GO:0045454 cell redox homeostasis 1.686E-6 4.967E-5 3.241E-4 6.457E-4 3 69
14 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 4.295E-6 1.175E-4 7.669E-4 1.645E-3 3 94
15 GO:0048010 vascular endothelial growth factor receptor signaling pathway 4.871E-6 1.244E-4 8.117E-4 1.866E-3 3 98
16 GO:1903409 reactive oxygen species biosynthetic process 5.826E-6 1.395E-4 9.102E-4 2.231E-3 3 104
17 GO:0002478 antigen processing and presentation of exogenous peptide antigen 2.371E-5 5.342E-4 3.487E-3 9.082E-3 3 166
18 GO:0071480 cellular response to gamma radiation 2.535E-5 5.393E-4 3.520E-3 9.708E-3 2 21
19 GO:0019884 antigen processing and presentation of exogenous antigen 2.683E-5 5.408E-4 3.530E-3 1.028E-2 3 173
20 GO:0048002 antigen processing and presentation of peptide antigen 3.278E-5 6.278E-4 4.097E-3 1.256E-2 3 185
21 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 6.359E-5 1.121E-3 7.315E-3 2.436E-2 2 33
22 GO:0019882 antigen processing and presentation 6.438E-5 1.121E-3 7.315E-3 2.466E-2 3 232
23 GO:0006739 NADP metabolic process 9.862E-5 1.642E-3 1.072E-2 3.777E-2 2 41
24 GO:0001990 regulation of systemic arterial blood pressure by hormone 1.244E-4 1.985E-3 1.295E-2 4.763E-2 2 46
25 GO:0071214 cellular response to abiotic stimulus 1.493E-4 2.287E-3 1.492E-2
5.717E-2
 3 308
26 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 1.781E-4 2.618E-3 1.708E-2
6.823E-2
 2 55
27 GO:0010332 response to gamma radiation 1.847E-4 2.618E-3 1.708E-2
7.074E-2
 2 56
28 GO:0070482 response to oxygen levels 1.965E-4 2.618E-3 1.708E-2
7.525E-2
 3 338
29 GO:0071479 cellular response to ionizing radiation 1.982E-4 2.618E-3 1.708E-2
7.591E-2
 2 58
30 GO:0032760 positive regulation of tumor necrosis factor production 3.057E-4 3.891E-3 2.539E-2
1.171E-1
 2 72
31 GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 3.229E-4 3.891E-3 2.539E-2
1.237E-1
 2 74
32 GO:0001819 positive regulation of cytokine production 3.674E-4 3.891E-3 2.539E-2
1.407E-1
 3 418
33 GO:1990451 cellular stress response to acidic pH 3.759E-4 3.891E-3 2.539E-2
1.440E-1
 1 1
34 GO:0003083 negative regulation of renal output by angiotensin 3.759E-4 3.891E-3 2.539E-2
1.440E-1
 1 1
35 GO:0014895 smooth muscle hypertrophy 3.759E-4 3.891E-3 2.539E-2
1.440E-1
 1 1
36 GO:0003106 negative regulation of glomerular filtration by angiotensin 3.759E-4 3.891E-3 2.539E-2
1.440E-1
 1 1
37 GO:0043012 regulation of fusion of sperm to egg plasma membrane 3.759E-4 3.891E-3 2.539E-2
1.440E-1
 1 1
38 GO:0048661 positive regulation of smooth muscle cell proliferation 4.062E-4 4.094E-3 2.672E-2
1.556E-1
 2 83
39 GO:0034765 regulation of ion transmembrane transport 4.713E-4 4.628E-3 3.021E-2
1.805E-1
 3 455
40 GO:0001525 angiogenesis 4.991E-4 4.779E-3 3.119E-2
1.912E-1
 3 464
41 GO:0034762 regulation of transmembrane transport 5.280E-4 4.933E-3 3.219E-2
2.022E-1
 3 473
42 GO:0050886 endocrine process 6.248E-4 5.565E-3 3.632E-2
2.393E-1
 2 103
43 GO:0003073 regulation of systemic arterial blood pressure 6.248E-4 5.565E-3 3.632E-2
2.393E-1
 2 103
44 GO:0009590 detection of gravity 7.516E-4 6.397E-3 4.175E-2
2.879E-1
 1 2
45 GO:0070946 neutrophil mediated killing of gram-positive bacterium 7.516E-4 6.397E-3 4.175E-2
2.879E-1
 1 2
46 GO:0001935 endothelial cell proliferation 8.749E-4 7.210E-3 4.706E-2
3.351E-1
 2 122
47 GO:0032680 regulation of tumor necrosis factor production 8.892E-4 7.210E-3 4.706E-2
3.406E-1
 2 123
48 GO:0032640 tumor necrosis factor production 9.036E-4 7.210E-3 4.706E-2
3.461E-1
 2 124
49 GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 9.328E-4 7.291E-3 4.758E-2
3.572E-1
 2 126
50 GO:0048660 regulation of smooth muscle cell proliferation 9.774E-4 7.340E-3 4.790E-2
3.743E-1
 2 129
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 28 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043020 NADPH oxidase complex 2.208E-20 6.183E-19 2.428E-18 6.183E-19 6 10
2 GO:1990204 oxidoreductase complex 1.035E-13 1.449E-12 5.691E-12 2.898E-12 6 97
3 GO:0045335 phagocytic vesicle 3.284E-6 3.065E-5 1.204E-4 9.195E-5 3 88
4 GO:0030139 endocytic vesicle 8.923E-5 6.246E-4 2.453E-3 2.498E-3 3 265
5 GO:0030670 phagocytic vesicle membrane 2.026E-4 1.011E-3 3.970E-3 5.672E-3 2 60
6 GO:0097517 contractile actin filament bundle 2.527E-4 1.011E-3 3.970E-3 7.076E-3 2 67
7 GO:0001725 stress fiber 2.527E-4 1.011E-3 3.970E-3 7.076E-3 2 67
8 GO:0032432 actin filament bundle 3.001E-4 1.039E-3 4.079E-3 8.402E-3 2 73
9 GO:0042641 actomyosin 3.339E-4 1.039E-3 4.079E-3 9.348E-3 2 77
10 GO:0005791 rough endoplasmic reticulum 4.764E-4 1.334E-3 5.238E-3 1.334E-2 2 92
11 GO:0030666 endocytic vesicle membrane 1.360E-3 3.463E-3 1.360E-2 3.809E-2 2 156
12 GO:0032010 phagolysosome 1.835E-3 4.282E-3 1.682E-2
5.138E-2
 1 5
13 GO:0071438 invadopodium membrane 2.202E-3 4.742E-3 1.862E-2
6.165E-2
 1 6
14 GO:0005767 secondary lysosome 2.935E-3 5.869E-3 2.305E-2
8.217E-2
 1 8
15 GO:0071437 invadopodium 4.399E-3 8.212E-3 3.225E-2
1.232E-1
 1 12
16 GO:0097038 perinuclear endoplasmic reticulum 5.497E-3 9.619E-3 3.778E-2
1.539E-1
 1 15
17 GO:0016324 apical plasma membrane 6.101E-3 1.005E-2 3.946E-2
1.708E-1
 2 335
18 GO:0005925 focal adhesion 8.314E-3 1.222E-2 4.799E-2
2.328E-1
 2 393
19 GO:0005924 cell-substrate adherens junction 8.520E-3 1.222E-2 4.799E-2
2.386E-1
 2 398
20 GO:0030055 cell-substrate junction 8.728E-3 1.222E-2 4.799E-2
2.444E-1
 2 403
21 GO:0045177 apical part of cell 9.803E-3 1.307E-2
5.133E-2
2.745E-1
 2 428
22 GO:0015629 actin cytoskeleton 1.203E-2 1.511E-2
5.936E-2
3.367E-1
 2 476
23 GO:0005912 adherens junction 1.242E-2 1.511E-2
5.936E-2
3.476E-1
 2 484
Show 18 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 190 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0002723 Absence of bactericidal oxidative respiratory burst in phagocytes 2.303E-10 5.469E-9 3.187E-8 4.375E-8 3 4
2 HP:0002740 Recurrent E. coli infections 2.303E-10 5.469E-9 3.187E-8 4.375E-8 3 4
3 HP:0004358 Abnormality of superoxide metabolism 2.303E-10 5.469E-9 3.187E-8 4.375E-8 3 4
4 HP:0002742 Recurrent Klebsiella infections 2.303E-10 5.469E-9 3.187E-8 4.375E-8 3 4
5 HP:0002741 Recurrent Serratia marcescens infections 2.303E-10 5.469E-9 3.187E-8 4.375E-8 3 4
6 HP:0002842 Recurrent Burkholderia cepacia infections 2.303E-10 5.469E-9 3.187E-8 4.375E-8 3 4
7 HP:0003206 Decreased activity of NADPH oxidase 2.303E-10 5.469E-9 3.187E-8 4.375E-8 3 4
8 HP:0003203 Impaired oxidative burst 2.303E-10 5.469E-9 3.187E-8 4.375E-8 3 4
9 HP:0002726 Recurrent Staphylococcus aureus infections 5.757E-10 1.094E-8 6.374E-8 1.094E-7 3 5
10 HP:0002724 Recurrent Aspergillus infections 5.757E-10 1.094E-8 6.374E-8 1.094E-7 3 5
11 HP:0007417 Discoid lupus rash 1.151E-9 1.989E-8 1.159E-7 2.188E-7 3 6
12 HP:0007499 Recurrent staphylococcal infections 2.015E-9 3.190E-8 1.859E-7 3.828E-7 3 7
13 HP:0005224 Rectal abscess 3.224E-9 4.712E-8 2.746E-7 6.125E-7 3 8
14 HP:0005549 Congenital neutropenia 4.836E-9 6.563E-8 3.824E-7 9.188E-7 3 9
15 HP:0000976 Eczematoid dermatitis 9.499E-9 1.203E-7 7.011E-7 1.805E-6 3 11
16 HP:0009789 Perianal abscess 1.267E-8 1.416E-7 8.248E-7 2.406E-6 3 12
17 HP:0005420 Recurrent gram-negative bacterial infections 1.267E-8 1.416E-7 8.248E-7 2.406E-6 3 12
18 HP:0100838 Recurrent cutaneous abscess formation 3.915E-8 3.915E-7 2.281E-6 7.438E-6 3 17
19 HP:0031292 Cutaneous abscess 3.915E-8 3.915E-7 2.281E-6 7.438E-6 3 17
20 HP:0000999 Pyoderma 5.579E-8 5.300E-7 3.088E-6 1.060E-5 3 19
21 HP:0011993 Impaired neutrophil bactericidal activity 6.563E-8 5.938E-7 3.460E-6 1.247E-5 3 20
22 HP:0011990 Abnormality of neutrophil physiology 8.866E-8 7.657E-7 4.462E-6 1.684E-5 3 22
23 HP:0003212 Increased IgE level 1.497E-7 1.237E-6 7.205E-6 2.844E-5 3 26
24 HP:0100658 Cellulitis 1.886E-7 1.493E-6 8.700E-6 3.583E-5 3 28
25 HP:0003514 Deficiency or absence of cytochrome b(-245) 2.709E-7 2.059E-6 1.200E-5 5.146E-5 2 2
26 HP:0005406 Recurrent bacterial skin infections 3.445E-7 2.517E-6 1.467E-5 6.545E-5 3 34
27 HP:0002043 Esophageal stricture 3.768E-7 2.557E-6 1.490E-5 7.159E-5 3 35
28 HP:0010450 Esophageal stenosis 3.768E-7 2.557E-6 1.490E-5 7.159E-5 3 35
29 HP:0010977 Abnormality of phagocytes 9.335E-7 6.116E-6 3.564E-5 1.774E-4 3 47
30 HP:0000155 Oral ulcer 9.957E-7 6.306E-6 3.675E-5 1.892E-4 3 48
31 HP:0002841 Recurrent fungal infections 1.128E-6 6.700E-6 3.904E-5 2.144E-4 3 50
32 HP:0011107 Recurrent aphthous stomatitis 1.128E-6 6.700E-6 3.904E-5 2.144E-4 3 50
33 HP:0001047 Atopic dermatitis 1.199E-6 6.903E-6 4.022E-5 2.278E-4 3 51
34 HP:0002840 Lymphadenitis 1.684E-6 9.413E-6 5.485E-5 3.201E-4 3 57
35 HP:0100279 Ulcerative colitis 1.776E-6 9.611E-6 5.600E-5 3.375E-4 3 58
36 HP:0100523 Liver abscess 1.872E-6 9.611E-6 5.600E-5 3.556E-4 3 59
37 HP:0002850 Decreased circulating total IgM 1.872E-6 9.611E-6 5.600E-5 3.556E-4 3 59
38 HP:0002955 Granulomatosis 1.970E-6 9.850E-6 5.740E-5 3.743E-4 3 60
39 HP:0004431 Complement deficiency 3.016E-6 1.469E-5 8.563E-5 5.731E-4 3 69
40 HP:0002722 Recurrent abscess formation 3.732E-6 1.759E-5 1.025E-4 7.091E-4 3 74
41 HP:0100721 Mediastinal lymphadenopathy 3.887E-6 1.759E-5 1.025E-4 7.386E-4 3 75
42 HP:0100722 Abnormality of the mediastinum 3.887E-6 1.759E-5 1.025E-4 7.386E-4 3 75
43 HP:0001061 Acne 4.047E-6 1.788E-5 1.042E-4 7.690E-4 3 76
44 HP:0045026 Abnormality of the mediastinum 4.553E-6 1.880E-5 1.096E-4 8.650E-4 3 79
45 HP:0045027 Abnormality of the thoracic cavity 4.553E-6 1.880E-5 1.096E-4 8.650E-4 3 79
46 HP:0002575 Tracheoesophageal fistula 4.553E-6 1.880E-5 1.096E-4 8.650E-4 3 79
47 HP:0002021 Pyloric stenosis 4.730E-6 1.912E-5 1.114E-4 8.987E-4 3 80
48 HP:0000230 Gingivitis 4.912E-6 1.944E-5 1.133E-4 9.333E-4 3 81
49 HP:0004400 Abnormality of the pylorus 5.098E-6 1.977E-5 1.152E-4 9.687E-4 3 82
50 HP:0004311 Abnormal macrophage morphology 5.686E-6 2.161E-5 1.259E-4 1.080E-3 3 85
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 6 input genes in category / 286 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002843 decreased systemic arterial blood pressure 2.528E-7 7.229E-5 4.507E-4 7.229E-5 4 120
2 MP:0003186 abnormal redox activity 8.663E-7 1.239E-4 7.724E-4 2.478E-4 4 163
3 MP:0006264 decreased systemic arterial systolic blood pressure 2.228E-6 2.124E-4 1.324E-3 6.372E-4 3 51
4 MP:0000230 abnormal systemic arterial blood pressure 5.515E-6 3.943E-4 2.459E-3 1.577E-3 4 259
5 MP:0002978 absent otoliths 2.928E-5 1.675E-3 1.044E-2 8.375E-3 2 15
6 MP:0004813 absent linear vestibular evoked potential 5.847E-5 2.601E-3 1.622E-2 1.672E-2 2 21
7 MP:0002862 altered righting response 6.365E-5 2.601E-3 1.622E-2 1.821E-2 3 155
8 MP:0002980 abnormal postural reflex 7.533E-5 2.693E-3 1.679E-2 2.154E-2 3 164
9 MP:0002894 abnormal otolith morphology 1.128E-4 3.358E-3 2.094E-2 3.227E-2 2 29
10 MP:0004812 abnormal linear vestibular evoked potential 1.208E-4 3.358E-3 2.094E-2 3.456E-2 2 30
11 MP:0002895 abnormal otolithic membrane morphology 1.291E-4 3.358E-3 2.094E-2 3.693E-2 2 31
12 MP:0002500 granulomatous inflammation 1.847E-4 4.078E-3 2.543E-2
5.282E-2
 2 37
13 MP:0001625 cardiac hypertrophy 1.854E-4 4.078E-3 2.543E-2
5.302E-2
 3 222
14 MP:0002462 abnormal granulocyte physiology 3.027E-4 5.595E-3 3.489E-2
8.656E-2
 3 262
15 MP:0005191 head tilt 3.119E-4 5.595E-3 3.489E-2
8.920E-2
 2 48
16 MP:0000272 abnormal aorta morphology 3.130E-4 5.595E-3 3.489E-2
8.952E-2
 3 265
17 MP:0004742 abnormal vestibular system physiology 4.718E-4 7.937E-3 4.949E-2
1.349E-1
 2 59
18 MP:0013799 abnormal intestinal goblet cell physiology 5.794E-4 9.003E-3
5.614E-2
1.657E-1
 1 1
19 MP:0002499 chronic inflammation 6.084E-4 9.003E-3
5.614E-2
1.740E-1
 2 67
20 MP:0011655 abnormal systemic artery morphology 6.296E-4 9.003E-3
5.614E-2
1.801E-1
 3 336
21 MP:0001522 impaired swimming 8.240E-4 1.122E-2
6.997E-2
2.357E-1
 2 78
22 MP:0004427 abnormal vestibular labyrinth morphology 1.095E-3 1.424E-2
8.879E-2
3.133E-1
 2 90
23 MP:0004845 absent vestibuloocular reflex 1.159E-3 1.441E-2
8.983E-2
3.314E-1
 1 2
24 MP:0000249 abnormal blood vessel physiology 1.217E-3 1.451E-2
9.046E-2
3.482E-1
 3 421
25 MP:0002406 increased susceptibility to infection 1.468E-3 1.680E-2
1.047E-1
4.200E-1
 3 449
26 MP:0000436 abnormal head movements 1.661E-3 1.827E-2
1.139E-1
4.750E-1
 2 111
27 MP:0011741 increased urine nitrite level 1.737E-3 1.840E-2
1.147E-1
4.969E-1
 1 3
28 MP:0001454 abnormal cued conditioning behavior 2.236E-3 2.007E-2
1.252E-1
6.394E-1
 2 129
29 MP:0003332 liver abscess 2.316E-3 2.007E-2
1.252E-1
6.624E-1
 1 4
30 MP:0013254 abnormal angiotensin I-converting enzyme activity 2.316E-3 2.007E-2
1.252E-1
6.624E-1
 1 4
31 MP:0003184 increased angiotensin I-converting enzyme activity 2.316E-3 2.007E-2
1.252E-1
6.624E-1
 1 4
32 MP:0005525 increased renal plasma flow rate 2.316E-3 2.007E-2
1.252E-1
6.624E-1
 1 4
33 MP:0002284 abnormal tracheal smooth muscle morphology 2.316E-3 2.007E-2
1.252E-1
6.624E-1
 1 4
34 MP:0003674 oxidative stress 2.777E-3 2.237E-2
1.395E-1
7.943E-1
 2 144
35 MP:0001525 impaired balance 2.892E-3 2.237E-2
1.395E-1
8.272E-1
 2 147
36 MP:0009868 abnormal descending thoracic aorta morphology 2.894E-3 2.237E-2
1.395E-1
8.278E-1
 1 5
37 MP:0005526 decreased renal plasma flow rate 2.894E-3 2.237E-2
1.395E-1
8.278E-1
 1 5
38 MP:0005088 increased acute inflammation 3.089E-3 2.325E-2
1.450E-1
8.835E-1
 2 152
39 MP:0001473 reduced long term potentiation 3.251E-3 2.383E-2
1.486E-1
9.298E-1
 2 156
40 MP:0005595 abnormal vascular smooth muscle physiology 3.333E-3 2.383E-2
1.486E-1
9.533E-1
 2 158
41 MP:0010759 decreased right ventricle systolic pressure 3.472E-3 2.422E-2
1.510E-1
9.931E-1
 1 6
42 MP:0005527 increased renal glomerular filtration rate 4.050E-3 2.694E-2
1.680E-1
1.000E0
 1 7
43 MP:0011740 abnormal urine nitrite level 4.050E-3 2.694E-2
1.680E-1
1.000E0
 1 7
44 MP:0002463 abnormal neutrophil physiology 4.258E-3 2.768E-2
1.726E-1
1.000E0
 2 179
45 MP:0011470 increased urine creatinine level 4.628E-3 2.941E-2
1.834E-1
1.000E0
 1 8
46 MP:0010936 decreased airway resistance 5.205E-3 3.101E-2
1.934E-1
1.000E0
 1 9
47 MP:0010697 abnormal systemic arterial blood pressure regulation 5.205E-3 3.101E-2
1.934E-1
1.000E0
 1 9
48 MP:0005524 abnormal renal plasma flow rate 5.205E-3 3.101E-2
1.934E-1
1.000E0
 1 9
49 MP:0005023 abnormal wound healing 5.446E-3 3.179E-2
1.982E-1
1.000E0
 2 203
50 MP:0005074 impaired granulocyte bactericidal activity 5.782E-3 3.293E-2
2.053E-1
1.000E0
 1 10
Show 45 more annotations

6: Domain [Display Chart] 7 input genes in category / 40 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR013112 FAD-bd 8 InterPro 2.294E-17 2.294E-16 9.813E-16 9.174E-16 5 7
2 PF08030 NAD binding 6 Pfam 2.294E-17 2.294E-16 9.813E-16 9.174E-16 5 7
3 IPR013121 Fe red NAD-bd 6 InterPro 2.294E-17 2.294E-16 9.813E-16 9.174E-16 5 7
4 PF08022 FAD binding 8 Pfam 2.294E-17 2.294E-16 9.813E-16 9.174E-16 5 7
5 IPR013130 Fe3 Rdtase TM dom InterPro 8.646E-16 5.764E-15 2.466E-14 3.458E-14 5 12
6 PF01794 Ferric reduct Pfam 8.646E-16 5.764E-15 2.466E-14 3.458E-14 5 12
7 IPR000778 Cyt b245 heavy chain InterPro 6.820E-15 3.897E-14 1.667E-13 2.728E-13 4 4
8 IPR017927 Fd Rdtase FAD-bd InterPro 1.269E-14 5.074E-14 2.171E-13 5.074E-13 5 19
9 PS51384 FAD FR PROSITE 1.269E-14 5.074E-14 2.171E-13 5.074E-13 5 19
10 IPR017938 Riboflavin synthase-like b-brl InterPro 1.269E-14 5.074E-14 2.171E-13 5.074E-13 5 19
11 IPR029648 NOX5 InterPro 3.736E-4 7.473E-4 3.197E-3 1.495E-2 1 1
12 PF08944 p47 phox C Pfam 3.736E-4 7.473E-4 3.197E-3 1.495E-2 1 1
13 IPR001655 P47PHOX InterPro 3.736E-4 7.473E-4 3.197E-3 1.495E-2 1 1
14 IPR007732 Cyt b558 asu InterPro 3.736E-4 7.473E-4 3.197E-3 1.495E-2 1 1
15 IPR029653 NOX3 InterPro 3.736E-4 7.473E-4 3.197E-3 1.495E-2 1 1
16 IPR032136 NECFESHC InterPro 3.736E-4 7.473E-4 3.197E-3 1.495E-2 1 1
17 IPR029650 NOX1 InterPro 3.736E-4 7.473E-4 3.197E-3 1.495E-2 1 1
18 PF16621 NECFESHC Pfam 3.736E-4 7.473E-4 3.197E-3 1.495E-2 1 1
19 IPR015039 NADPH oxidase p47Phox C InterPro 3.736E-4 7.473E-4 3.197E-3 1.495E-2 1 1
20 PF05038 Cytochrom B558a Pfam 3.736E-4 7.473E-4 3.197E-3 1.495E-2 1 1
21 IPR001709 Flavoprot Pyr Nucl cyt Rdtase InterPro 3.731E-3 7.107E-3 3.041E-2
1.492E-1
 1 10
22 PF13405 EF-hand 6 Pfam 4.848E-3 8.814E-3 3.771E-2
1.939E-1
 1 13
23 PF13202 EF-hand 5 Pfam 9.305E-3 1.618E-2
6.924E-2
3.722E-1
 1 25
24 SM00312 PX SMART 1.633E-2 2.721E-2
1.164E-1
6.531E-1
 1 44
25 PF00787 PX Pfam 1.817E-2 2.753E-2
1.178E-1
7.267E-1
 1 49
26 PS50195 PX PROSITE 1.854E-2 2.753E-2
1.178E-1
7.414E-1
 1 50
27 3.30.1520.10 - Gene3D 1.890E-2 2.753E-2
1.178E-1
7.561E-1
 1 51
28 IPR001683 Phox InterPro 1.927E-2 2.753E-2
1.178E-1
7.708E-1
 1 52
Show 23 more annotations

7: Pathway [Display Chart] 7 input genes in category / 28 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269521 RHO GTPases Activate NADPH Oxidases BioSystems: REACTOME 1.084E-14 3.035E-13 1.192E-12 3.035E-13 5 13
2 1270420 Detoxification of Reactive Oxygen Species BioSystems: REACTOME 4.213E-12 5.899E-11 2.317E-10 1.180E-10 5 38
3 SMP00006 Tyrosine Metabolism SMPDB 3.703E-10 3.456E-9 1.357E-8 1.037E-8 4 24
4 83083 Leukocyte transendothelial migration BioSystems: KEGG 1.220E-9 8.538E-9 3.353E-8 3.415E-8 5 114
5 193147 Osteoclast differentiation BioSystems: KEGG 2.373E-9 1.329E-8 5.219E-8 6.645E-8 5 130
6 1474302 Fluid shear stress and atherosclerosis BioSystems: KEGG 3.709E-9 1.731E-8 6.797E-8 1.038E-7 5 142
7 153910 Phagosome BioSystems: KEGG 5.586E-9 2.131E-8 8.368E-8 1.564E-7 5 154
8 1269196 Cross-presentation of particulate exogenous antigens (phagosomes) BioSystems: REACTOME 6.088E-9 2.131E-8 8.368E-8 1.705E-7 3 8
9 169355 RAC1 signaling pathway BioSystems: Pathway Interaction Database 1.096E-8 3.409E-8 1.339E-7 3.068E-7 4 54
10 1269509 RHO GTPase Effectors BioSystems: REACTOME 1.459E-7 4.085E-7 1.604E-6 4.085E-6 5 295
11 1269138 ROS, RNS production in phagocytes BioSystems: REACTOME 5.896E-7 1.501E-6 5.894E-6 1.651E-5 3 33
12 1269507 Signaling by Rho GTPases BioSystems: REACTOME 9.525E-7 2.222E-6 8.728E-6 2.667E-5 5 430
13 122191 NOD-like receptor signaling pathway BioSystems: KEGG 1.138E-6 2.450E-6 9.622E-6 3.185E-5 4 170
14 1270414 Cellular responses to stress BioSystems: REACTOME 1.247E-6 2.494E-6 9.795E-6 3.492E-5 5 454
15 1319988 AGE-RAGE signaling pathway in diabetic complications BioSystems: KEGG 1.668E-5 3.095E-5 1.215E-4 4.671E-4 3 99
16 695200 HIF-1 signaling pathway BioSystems: KEGG 1.771E-5 3.095E-5 1.215E-4 4.960E-4 3 101
17 1269195 Antigen processing-Cross presentation BioSystems: REACTOME 1.879E-5 3.095E-5 1.215E-4 5.261E-4 3 103
18 1269483 VEGFA-VEGFR2 Pathway BioSystems: REACTOME 6.127E-4 9.531E-4 3.743E-3 1.716E-2 3 333
19 1269480 Signaling by VEGF BioSystems: REACTOME 6.568E-4 9.679E-4 3.801E-3 1.839E-2 3 341
20 144181 Leishmaniasis BioSystems: KEGG 6.987E-4 9.782E-4 3.842E-3 1.956E-2 2 73
21 1269192 Class I MHC mediated antigen processing & presentation BioSystems: REACTOME 8.737E-4 1.165E-3 4.575E-3 2.446E-2 3 376
22 M96 Free Radical Induced Apoptosis MSigDB C2 BIOCARTA (v6.0) 5.610E-3 7.140E-3 2.804E-2
1.571E-1
 1 10
23 M9152 CCR3 signaling in Eosinophils MSigDB C2 BIOCARTA (v6.0) 1.286E-2 1.566E-2
6.150E-2
3.602E-1
 1 23
24 1510435 Ferroptosis BioSystems: KEGG 2.228E-2 2.599E-2
1.021E-1
6.238E-1
 1 40
25 138017 Signaling events mediated by PTP1B BioSystems: Pathway Interaction Database 2.778E-2 3.089E-2
1.213E-1
7.779E-1
 1 50
26 1457780 Neutrophil degranulation BioSystems: REACTOME 2.868E-2 3.089E-2
1.213E-1
8.031E-1
 2 492
Show 21 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 2185 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 21212270 Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4. Pubmed 1.737E-18 3.795E-15 3.137E-14 3.795E-15 5 8
2 27912196 NOX isoforms in the development of abdominal aortic aneurysm. Pubmed 3.948E-16 1.232E-13 1.019E-12 8.627E-13 4 4
3 9882350 Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1-immunosuppressive tat and gp160 proteins. Pubmed 3.948E-16 1.232E-13 1.019E-12 8.627E-13 4 4
4 26297224 Impaired compensation to femoral artery ligation in diet-induced obese mice is primarily mediated via suppression of collateral growth by Nox2 and p47phox. Pubmed 3.948E-16 1.232E-13 1.019E-12 8.627E-13 4 4
5 27614387 CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity. Pubmed 3.948E-16 1.232E-13 1.019E-12 8.627E-13 4 4
6 24051369 Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury. Pubmed 3.948E-16 1.232E-13 1.019E-12 8.627E-13 4 4
7 22277655 Constitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminus. Pubmed 3.948E-16 1.232E-13 1.019E-12 8.627E-13 4 4
8 24608713 Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction. Pubmed 1.974E-15 4.793E-13 3.962E-12 4.313E-12 4 5
9 21901141 Impaired OXPHOS complex III in breast cancer. Pubmed 1.974E-15 4.793E-13 3.962E-12 4.313E-12 4 5
10 15256399 Systemic regulation of vascular NAD(P)H oxidase activity and nox isoform expression in human arteries and veins. Pubmed 5.922E-15 1.176E-12 9.724E-12 1.294E-11 4 6
11 16775014 The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Pubmed 5.922E-15 1.176E-12 9.724E-12 1.294E-11 4 6
12 19005069 Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. Pubmed 1.382E-14 2.516E-12 2.080E-11 3.019E-11 4 7
13 15509740 Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase. Pubmed 4.973E-14 8.359E-12 6.910E-11 1.087E-10 4 9
14 21483469 A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse cases. Pubmed 9.389E-13 1.465E-10 1.211E-9 2.052E-9 4 17
15 22933115 NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
16 26760964 Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
17 20877715 Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
18 16207877 Expression and modulation of an NADPH oxidase in mammalian astrocytes. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
19 20708598 Characterization of superoxide overproduction by the D-Loop(Nox4)-Nox2 cytochrome b(558) in phagocytes-Differential sensitivity to calcium and phosphorylation events. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
20 20495074 Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
21 18952568 The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
22 17336700 A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
23 22549734 The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
24 20407811 Molecular basis of autosomal recessive chronic granulomatous disease in iran. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
25 10974555 NADPH oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon epithelial cells. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
26 20493939 NADPH oxidase-derived superoxide impairs calcium transients and contraction in aged murine ventricular myocytes. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
27 11376945 Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
28 15322091 Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
29 19471020 Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
30 22456182 Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
31 19843513 Intrarenal artery superoxide is mainly NADPH oxidase-derived and modulates endothelium-dependent dilation in elderly patients. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
32 28165467 APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
33 27399878 The NADPH Oxidase Nox2 Mediates Vitamin D-Induced Vascular Regeneration in Male Mice. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
34 24563256 Influenza infection suppresses NADPH oxidase-dependent phagocytic bacterial clearance and enhances susceptibility to secondary methicillin-resistant Staphylococcus aureus infection. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
35 15102091 A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
36 24213612 Nox-derived ROS are acutely activated in pressure overload pulmonary hypertension: indications for a seminal role for mitochondrial Nox4. Pubmed 3.770E-12 2.288E-10 1.891E-9 8.237E-9 3 3
37 20056178 Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. Pubmed 1.333E-11 7.162E-10 5.921E-9 2.912E-8 5 141
38 12482831 Cytochrome b558-dependent NAD(P)H oxidase-phox units in smooth muscle and macrophages of atherosclerotic lesions. Pubmed 1.508E-11 7.162E-10 5.921E-9 3.294E-8 3 4
39 20195241 Oxidative stress mediates nephropathy in type Ia glycogen storage disease. Pubmed 1.508E-11 7.162E-10 5.921E-9 3.294E-8 3 4
40 26317224 INF-γ Enhances Nox2 Activity by Upregulating phox Proteins When Applied to Differentiating PLB-985 Cells but Does Not Induce Nox2 Activity by Itself. Pubmed 1.508E-11 7.162E-10 5.921E-9 3.294E-8 3 4
41 18546332 Molecular epidemiology of chronic granulomatous disease in a series of 80 kindreds: identification of 31 novel mutations. Pubmed 1.508E-11 7.162E-10 5.921E-9 3.294E-8 3 4
42 21677136 Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. Pubmed 1.508E-11 7.162E-10 5.921E-9 3.294E-8 3 4
43 26036345 Augmented EGF receptor tyrosine kinase activity impairs vascular function by NADPH oxidase-dependent mechanism in type 2 diabetic mouse. Pubmed 1.508E-11 7.162E-10 5.921E-9 3.294E-8 3 4
44 17200123 NAD(P)H oxidases regulate HIF-2alpha protein expression. Pubmed 1.508E-11 7.162E-10 5.921E-9 3.294E-8 3 4
45 11248021 Assembly of the neutrophil respiratory burst oxidase: a direct interaction between p67PHOX and cytochrome b558. Pubmed 1.508E-11 7.162E-10 5.921E-9 3.294E-8 3 4
46 22337127 Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Pubmed 1.508E-11 7.162E-10 5.921E-9 3.294E-8 3 4
47 22876374 Chronic Granulomatous Disease Pubmed 3.769E-11 1.554E-9 1.285E-8 8.235E-8 3 5
48 30062795 Pulmonary metastatic colonisation and granulomas in NOX2-deficient mice. Pubmed 3.769E-11 1.554E-9 1.285E-8 8.235E-8 3 5
49 25116588 Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways. Pubmed 3.769E-11 1.554E-9 1.285E-8 8.235E-8 3 5
50 18182394 Regulation of TGFbeta1-mediated collagen formation by LOX-1: studies based on forced overexpression of TGFbeta1 in wild-type and lox-1 knock-out mouse cardiac fibroblasts. Pubmed 3.769E-11 1.554E-9 1.285E-8 8.235E-8 3 5
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 80 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CYBA CYBA interactions 6.666E-12 5.333E-10 2.648E-9 5.333E-10 4 16
2 int:NCF4 NCF4 interactions 3.566E-9 1.268E-7 6.295E-7 2.853E-7 3 11
3 int:CYBB CYBB interactions 4.754E-9 1.268E-7 6.295E-7 3.803E-7 3 12
4 int:NCF2 NCF2 interactions 6.308E-8 1.262E-6 6.265E-6 5.047E-6 3 27
5 int:NCF1 NCF1 interactions 4.478E-7 7.164E-6 3.557E-5 3.582E-5 3 51
6 int:NOX1 NOX1 interactions 9.569E-7 1.276E-5 6.335E-5 7.655E-5 2 5
7 int:NOXA1 NOXA1 interactions 1.146E-5 1.310E-4 6.505E-4 9.171E-4 2 16
8 int:RAC1 RAC1 interactions 5.393E-5 5.393E-4 2.678E-3 4.315E-3 3 250
9 int:MGAM MGAM interactions 6.778E-4 6.024E-3 2.991E-2
5.422E-2
 1 2
10 int:NOXO1 NOXO1 interactions 1.016E-3 8.132E-3 4.038E-2
8.132E-2
 1 3
11 int:ACTG1 ACTG1 interactions 1.619E-3 1.129E-2
5.607E-2
1.295E-1
 2 187
12 int:NOX4 NOX4 interactions 1.694E-3 1.129E-2
5.607E-2
1.355E-1
 1 5
13 int:LTB4R LTB4R interactions 2.370E-3 1.459E-2
7.243E-2
1.896E-1
 1 7
14 int:SYTL1 SYTL1 interactions 2.709E-3 1.548E-2
7.686E-2
2.167E-1
 1 8
15 int:GP6 GP6 interactions 4.399E-3 1.955E-2
9.707E-2
3.519E-1
 1 13
16 int:PDP2 PDP2 interactions 4.399E-3 1.955E-2
9.707E-2
3.519E-1
 1 13
17 int:NOX5 NOX5 interactions 4.399E-3 1.955E-2
9.707E-2
3.519E-1
 1 13
18 int:MYBPC3 MYBPC3 interactions 4.399E-3 1.955E-2
9.707E-2
3.519E-1
 1 13
19 int:MYBPC1 MYBPC1 interactions 5.074E-3 2.136E-2
1.061E-1
4.059E-1
 1 15
20 int:PPP2R3B PPP2R3B interactions 5.411E-3 2.165E-2
1.075E-1
4.329E-1
 1 16
21 int:RHBDD1 RHBDD1 interactions 6.086E-3 2.213E-2
1.099E-1
4.869E-1
 1 18
22 int:GUCY1B1 GUCY1B1 interactions 6.086E-3 2.213E-2
1.099E-1
4.869E-1
 1 18
23 int:ACTB ACTB interactions 7.054E-3 2.366E-2
1.175E-1
5.643E-1
 2 396
24 int:MTHFR MTHFR interactions 7.097E-3 2.366E-2
1.175E-1
5.678E-1
 1 21
25 int:DDRGK1 DDRGK1 interactions 1.248E-2 3.839E-2
1.906E-1
9.981E-1
 1 37
26 int:GP1BB GP1BB interactions 1.248E-2 3.839E-2
1.906E-1
9.981E-1
 1 37
27 int:TGFB1I1 TGFB1I1 interactions 1.449E-2 4.068E-2
2.020E-1
1.000E0
 1 43
28 int:PRKAR1B PRKAR1B interactions 1.516E-2 4.068E-2
2.020E-1
1.000E0
 1 45
29 int:TRIM9 TRIM9 interactions 1.549E-2 4.068E-2
2.020E-1
1.000E0
 1 46
30 int:PLA2G4A PLA2G4A interactions 1.549E-2 4.068E-2
2.020E-1
1.000E0
 1 46
31 int:IL4R IL4R interactions 1.650E-2 4.068E-2
2.020E-1
1.000E0
 1 49
32 int:GAA GAA interactions 1.716E-2 4.068E-2
2.020E-1
1.000E0
 1 51
33 int:CPT1A CPT1A interactions 1.716E-2 4.068E-2
2.020E-1
1.000E0
 1 51
34 int:TLR4 TLR4 interactions 1.750E-2 4.068E-2
2.020E-1
1.000E0
 1 52
35 int:SH3GL3 SH3GL3 interactions 1.850E-2 4.068E-2
2.020E-1
1.000E0
 1 55
36 int:TAGLN TAGLN interactions 1.850E-2 4.068E-2
2.020E-1
1.000E0
 1 55
37 int:SLC2A12 SLC2A12 interactions 1.917E-2 4.068E-2
2.020E-1
1.000E0
 1 57
38 int:SYN1 SYN1 interactions 1.950E-2 4.068E-2
2.020E-1
1.000E0
 1 58
39 int:TTC4 TTC4 interactions 1.983E-2 4.068E-2
2.020E-1
1.000E0
 1 59
40 int:WBP11 WBP11 interactions 2.050E-2 4.100E-2
2.036E-1
1.000E0
 1 61
41 int:NFE2L2 NFE2L2 interactions 2.482E-2 4.844E-2
2.405E-1
1.000E0
 1 74
42 int:WASF1 WASF1 interactions 2.549E-2 4.855E-2
2.411E-1
1.000E0
 1 76
Show 37 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11q14.2-q21 11q14.2-q21 2.020E-4 1.414E-3 3.666E-3 1.414E-3 1 1
2 16q24 16q24 3.429E-3 1.015E-2 2.631E-2 2.400E-2 1 17
3 Xq22 Xq22 4.435E-3 1.015E-2 2.631E-2 3.104E-2 1 22
4 6q25.3 6q25.3 7.048E-3 1.015E-2 2.631E-2 4.933E-2 1 35
5 Xp21.1 Xp21.1 7.248E-3 1.015E-2 2.631E-2
5.074E-2
 1 36
6 15q23 15q23 9.053E-3 1.056E-2 2.739E-2
6.337E-2
 1 45
7 7q11.23 7q11.23 2.062E-2 2.062E-2
5.346E-2
1.443E-1
 1 103
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 14 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$IRF Q6 V$IRF Q6 2.154E-3 3.016E-2
9.807E-2
 3.016E-2 2 188

12: Gene Family [Display Chart] 1 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 863 EF-hand domain containing genenames.org 1.204E-2 1.204E-2 1.204E-2 1.204E-2 1 219

13: Coexpression [Display Chart] 7 input genes in category / 660 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16434974-Table2 Human StemCell Enk06 334genes GeneSigDB 5.988E-11 3.952E-8 2.794E-7 3.952E-8 4 28
2 20460173-ImmPortAntimicrobials Human Immune Kong10 544genes ImmPort Antimicrobials GeneSigDB 6.805E-8 2.246E-5 1.588E-4 4.491E-5 5 469
3 M4037 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 2.171E-5 3.582E-3 2.532E-2 1.433E-2 3 200
4 M4349 Genes up-regulated in comparison of lung tissue from wild type mice versus that from TLR4 [GeneID=7099] deficient animals. MSigDB C7: Immunologic Signatures (v6.0) 2.171E-5 3.582E-3 2.532E-2 1.433E-2 3 200
5 M18107 Atherosclerotic process genes whose coronary expression changed after darapladib [PubChem=9939609] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.173E-5 4.189E-3 2.961E-2 2.094E-2 2 29
6 M8273 Genes up-regulated in ANBL-6 cell line (multiple myeloma, MM) expressing an activated form of NRAS [GeneID=4893] off a plasmid vector compared to those co-cultured with bone marrow stromal cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.398E-5 5.661E-3 4.003E-2 4.223E-2 2 41
7 M1138 Genes up-regulated in ANBL-6 cell line (multiple myeloma, MM) expressing a constantly active form of NRAS [GeneID=4893] off a plasmid vector compared to those grown in the presence of IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.398E-5 5.661E-3 4.003E-2 4.223E-2 2 41
8 16597596-TableS1-6 Human Leukemia Wilson06 50genes DifferentialClusterF GeneSigDB 7.378E-5 5.661E-3 4.003E-2 4.869E-2 2 44
9 12791645-Table4 Human BoneMarrow Croonquist03 49genes GeneSigDB 7.720E-5 5.661E-3 4.003E-2
5.095E-2
 2 45
10 15642130-TableS1 Rat Immune Rioja04 438genes GeneSigDB 9.218E-5 6.084E-3 4.301E-2
6.084E-2
 3 325
11 12077300-SuppTable2 Human Lymphoma Lossos02 152genes GeneSigDB 3.753E-4 2.252E-2
1.592E-1
2.477E-1
 2 99
12 18547747-Table1 Human Leukemia Mollinedo08 117genes GeneSigDB 5.237E-4 2.861E-2
2.023E-1
3.456E-1
 2 117
13 M19618 Hepatic graft versus host disease (GVHD), day 35: genes up-regulated in allogeneic vs syngeneic bone marrow transplant. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.558E-4 2.861E-2
2.023E-1
4.328E-1
 2 131
14 16140871-SuppTable7 Human Leukemia Toren05 224genes GeneSigDB 9.160E-4 2.861E-2
2.023E-1
6.046E-1
 2 155
15 M6720 Genes down-regulated in endothelial cells: IFNG [GeneID=3459] versus IFNG [GeneID=3459] and B. burgdoferi. MSigDB C7: Immunologic Signatures (v6.0) 1.126E-3 2.861E-2
2.023E-1
7.431E-1
 2 172
16 M5413 Genes up-regulated in comparison of eosinophils versus basophils. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.861E-2
2.023E-1
9.916E-1
 2 199
17 M3584 Genes up-regulated in comparison of medullary macrophages versus subcapsular sinus (SCS) macrophages. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
18 M5697 Genes down-regulated in comparsion of WTActCD4 versus WTActCD4TGF (see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
19 M5783 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with type 1 diabetes at the time of the diagnosis versus those at 1 month later. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
20 M9310 Genes down-regulated in follicular B cells versus day 40 germinal center B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
21 M7153 Genes up-regulated in CD4 [GeneID=920] T cells versus follicular helper CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
22 M7767 Genes down-regulated in macrophages 48h after M. bovis BCG infection: wildtype versus MYD88 [GeneID=4615] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
23 M7293 Genes down-regulated in lymphocytes treated with medium for 2h: T conv versus T reg cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
24 M7490 Genes up-regulated in NCAM1+ SELL bright [GeneID=4684;6402] versus NCAM1- SELL dim [GeneID=4684;6402]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
25 M7777 Genes up-regulated in macrophages: untreated versus 48h after M. bovis BCG infection. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
26 M8061 Genes down-regulated in plasmacytoid dendritic cells: wildtype versus TCF4 [GeneID=6925] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
27 M6459 Genes up-regulated in T cells: CD4 [GeneID=920] versus CD8A CD8B [GeneID=925;926]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
28 M9957 Genes down-regulated during primary acute viral infection: NK cells versus ITGAM+ [GeneID=3684] dendritic cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
29 M9663 Genes up-regulated in CD4 [GeneID=920] T helper cells Th0: 1h versus 42h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
30 M8064 Genes up-regulated in plasmacytoid dendritic cells (4 days after knockout): wildtype versus TCF4 [GeneID=6925] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
31 M7760 Genes up-regulated in macrophages: wildtype versus MYD88 [GeneID=4615] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
32 M7420 Genes up-regulated in mature neuron cell line: control versus interferon alpha (6h). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
33 M5472 Genes up-regulated in comparison of dendritic cells (DC) versus basophils. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
34 M5602 Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells versus those treated witl IL1B [GeneID=3553], IL6 [GeneID=3569] and IL23A [GeneID=51561]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
35 M9750 Genes up-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: follicular helper (Tfh) versus Ly6c low CXCR5- [GeneID=643]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.861E-2
2.023E-1
1.000E0
 2 200
36 19795415-Table1 Mouse Lung Beisiegel09 262genes GeneSigDB 1.624E-3 2.978E-2
2.105E-1
1.000E0
 2 207
37 16585964-SuppTable6 Mouse Lung not cancer Thimmulappa06 8genes GeneSigDB 1.814E-3 3.236E-2
2.288E-1
1.000E0
 1 6
38 19880498-TableS6 Human Leukemia Kang09 352genes GeneSigDB 2.017E-3 3.389E-2
2.396E-1
1.000E0
 2 231
39 11786402-Table3 Mouse Lung not cancer Fink02 9genes GeneSigDB 2.116E-3 3.389E-2
2.396E-1
1.000E0
 1 7
40 15284076-Table4 Human Lung not cancer Golpon04 8genes GeneSigDB 2.116E-3 3.389E-2
2.396E-1
1.000E0
 1 7
41 M5311 Genes from 'subtype S1' signature of hepatocellular carcinoma (HCC): aberrant activation of the WNT signaling pathway. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.121E-3 3.389E-2
2.396E-1
1.000E0
 2 237
42 M15425 Down-regulated genes from the optimal set of 550 markers discriminating breast cancer samples by ESR1 [GeneID=2099] expression: ER(+) vs ER(-) tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.156E-3 3.389E-2
2.396E-1
1.000E0
 2 239
43 M10454 Genes up-regulated in pulpal tissue extracted from carious teeth. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.412E-3 3.702E-2
2.618E-1
1.000E0
 2 253
44 M4707 Genes down-regulated during transition from G2 (moderately differentiated tumor, infected with HCV) to G3 (poorly differentiated tumor, infected with HCV) in the development of hepatocellular carcinoma. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.720E-3 4.080E-2
2.885E-1
1.000E0
 1 9
45 19520915-Table2 Mouse Lung not cancer Blake10 10genes GeneSigDB 3.022E-3 4.432E-2
3.134E-1
1.000E0
 1 10
46 M14418 Neutrophil-specific genes up-regulated in comparison of immature with mature neutrophils. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.324E-3 4.769E-2
3.372E-1
1.000E0
 1 11
Show 41 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 985 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/Kupffer cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/Kupffer cell Tabula Muris Consortium 5.580E-6 1.088E-3 8.127E-3 5.496E-3 3 120
2 BrainMap BrainAtlas - Mouse McCarroll Macrophage Macrophage Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Macrophage Macrophage Overall Top 200 Genes BrainMap 1.587E-5 1.088E-3 8.127E-3 1.564E-2 3 170
3 BrainMap BrainAtlas - Mouse McCarroll Macrophage. Macrophage. Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Macrophage. Macrophage. Overall Top 200 Genes BrainMap 1.587E-5 1.088E-3 8.127E-3 1.564E-2 3 170
4 BrainMap BrainAtlas - Mouse McCarroll Macrophage Macrophage Top 200 BrainMap BrainAtlas - Mouse McCarroll Macrophage Macrophage Top 200 BrainMap 1.587E-5 1.088E-3 8.127E-3 1.564E-2 3 170
5 BrainMap BrainAtlas - Mouse McCarroll Macrophage. Macrophage. Top 200 BrainMap BrainAtlas - Mouse McCarroll Macrophage. Macrophage. Top 200 BrainMap 1.587E-5 1.088E-3 8.127E-3 1.564E-2 3 170
6 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Macrophage Top 200 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Macrophage Top 200 1.587E-5 1.088E-3 8.127E-3 1.564E-2 3 170
7 BrainMap BrainAtlas - Mouse McCarroll Macrophage. .C1qb Macrophage. .C1qb Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Macrophage. .C1qb Macrophage. .C1qb Overall Top 200 Genes BrainMap 1.587E-5 1.088E-3 8.127E-3 1.564E-2 3 170
8 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Macrophage Overall Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Macrophage Overall Top 200 Genes 1.587E-5 1.088E-3 8.127E-3 1.564E-2 3 170
9 BrainMap BrainAtlas - Mouse McCarroll Macrophage. .C1qb Macrophage. .C1qb Top 200 BrainMap BrainAtlas - Mouse McCarroll Macrophage. .C1qb Macrophage. .C1qb Top 200 BrainMap 1.587E-5 1.088E-3 8.127E-3 1.564E-2 3 170
10 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Macrophage BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Macrophage BrainMap 1.615E-5 1.088E-3 8.127E-3 1.591E-2 3 171
11 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/leukocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/leukocyte Tabula Muris Consortium 1.947E-5 1.088E-3 8.127E-3 1.918E-2 3 182
12 10X Human 8K PBMC B cells CD79A-MS4A1-CD79B Overall Top 200 Genes 10X Human 8K PBMC B cells CD79A-MS4A1-CD79B Overall Top 200 Genes 1.979E-5 1.088E-3 8.127E-3 1.949E-2 3 183
13 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/leukocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/leukocyte Tabula Muris Consortium 2.044E-5 1.088E-3 8.127E-3 2.014E-2 3 185
14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-D/Kidney NephrogenicRest Wilms EN-D Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-D/Kidney NephrogenicRest Wilms EN-D Adult, Development, and Cancer types 2.044E-5 1.088E-3 8.127E-3 2.014E-2 3 185
15 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Limb Muscle/macrophage Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Limb Muscle/macrophage Tabula Muris Consortium 2.078E-5 1.088E-3 8.127E-3 2.047E-2 3 186
16 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow Tabula Muris Consortium 2.111E-5 1.088E-3 8.127E-3 2.080E-2 3 187
17 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea/blood cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea/blood cell Tabula Muris Consortium 2.111E-5 1.088E-3 8.127E-3 2.080E-2 3 187
18 10X Human 8K PBMC CD14+ Monocytes (S100A9, S100A8, LYZ) Overall Top 200 Genes 10X Human 8K PBMC CD14+ Monocytes (S100A9, S100A8, LYZ) Overall Top 200 Genes 2.285E-5 1.088E-3 8.127E-3 2.250E-2 3 192
19 10X Human 8K PBMC CD14+ Monocytes (S100A9, S100A8, LYZ) Top 200 10X Human 8K PBMC CD14+ Monocytes (S100A9, S100A8, LYZ) Top 200 2.285E-5 1.088E-3 8.127E-3 2.250E-2 3 192
20 10X Human 8K PBMC CD4 T-cells (S100A9, S100A8, LYZ) Top 200 10X Human 8K PBMC CD4 T-cells (S100A9, S100A8, LYZ) Top 200 2.320E-5 1.088E-3 8.127E-3 2.286E-2 3 193
21 10X Human 8K PBMC CD4 T-cells (S100A9, S100A8, LYZ) Overall Top 200 Genes 10X Human 8K PBMC CD4 T-cells (S100A9, S100A8, LYZ) Overall Top 200 Genes 2.320E-5 1.088E-3 8.127E-3 2.286E-2 3 193
22 10X Human 8K PBMC CD14+ Monocytes Overall Top 200 Genes 10X Human 8K PBMC CD14+ Monocytes Overall Top 200 Genes 2.430E-5 1.088E-3 8.127E-3 2.393E-2 3 196
23 Kidney10XCellRanger Six2KI P0 Unknown Unknown Subtype P0-Six2KI-Unknown-C3-KC9 Top 200 Genes Kidney10XCellRanger Six2KI P0 Unknown Unknown Subtype P0-Six2KI-Unknown-C3-KC9 Top 200 Genes 3.159E-5 1.265E-3 9.448E-3 3.111E-2 3 214
24 Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype macrophage - intermediate - unactivated PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype macrophage - intermediate - unactivated PND07-28 Top 200 Genes 3.248E-5 1.265E-3 9.448E-3 3.199E-2 3 216
25 Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype Proliferative Myeloid Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype Proliferative Myeloid Top 200 Genes 3.338E-5 1.265E-3 9.448E-3 3.288E-2 3 218
26 Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype Proliferative Myeloid E16.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype Proliferative Myeloid E16.5 Top 200 Genes 3.338E-5 1.265E-3 9.448E-3 3.288E-2 3 218
27 Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype CD163+ Macrophage PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype CD163+ Macrophage PND07-28 Top 200 Genes 3.572E-5 1.273E-3 9.513E-3 3.518E-2 3 223
28 Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype CD163+ Macrophage Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype CD163+ Macrophage Top 200 Genes 3.620E-5 1.273E-3 9.513E-3 3.566E-2 3 224
29 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype Neutrophil Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype Neutrophil Top 200 Genes 4.558E-5 1.484E-3 1.109E-2 4.489E-2 3 242
30 Lungmap Mouse Lung PND3 Immune Subtype Immune-B Lungmap Mouse Lung PND3 Immune Subtype Immune-B Lungmap CCHMC 4.671E-5 1.484E-3 1.109E-2 4.601E-2 3 244
31 Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype macrophage-B PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype macrophage-B PND01-03 Top 200 Genes 4.671E-5 1.484E-3 1.109E-2 4.601E-2 3 244
32 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour VHL RCC U U/Kidney Tumour VHL RCC U7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour VHL RCC U U/Kidney Tumour VHL RCC U7 Adult, Development, and Cancer types 6.495E-5 1.999E-3 1.493E-2
6.397E-2
 2 39
33 Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype CD163+ Macrophage E16.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype CD163+ Macrophage E16.5 Top 200 Genes 7.492E-5 2.236E-3 1.671E-2
7.380E-2
 3 286
34 Mouse Lung Development Lungmap Mouse Fluidigm Myeloid Subtype macrophage-B PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Myeloid Subtype macrophage-B PND01-03 Top 200 Genes 9.157E-5 2.653E-3 1.982E-2
9.020E-2
 3 306
35 Mouse Lung Development Lungmap Mouse Fluidigm Myeloid Subtype CD163+ Macrophage PND07-28 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Myeloid Subtype CD163+ Macrophage PND07-28 Top 200 Genes 1.146E-4 3.191E-3 2.384E-2
1.128E-1
 3 330
36 Mouse Lung Development Lungmap Mouse Fluidigm Myeloid Subtype CD163+ Macrophage Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Myeloid Subtype CD163+ Macrophage Top 200 Genes 1.166E-4 3.191E-3 2.384E-2
1.149E-1
 3 332
37 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour PapRCC R U/Kidney Tumour PapRCC R4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour PapRCC R U/Kidney Tumour PapRCC R4 Adult, Development, and Cancer types 1.298E-4 3.457E-3 2.582E-2
1.279E-1
 2 55
38 10X Human 8K PBMC B cells CD79A-MS4A1-CD79B Subtype B cells CD79A-MS4A1-CD79B-B cells subclass-0 (CD79A, IGHD, IGLC3) Top 200 Genes 10X Human 8K PBMC B cells CD79A-MS4A1-CD79B Subtype B cells CD79A-MS4A1-CD79B-B cells subclass-0 (CD79A, IGHD, IGLC3) Top 200 Genes 1.482E-4 3.771E-3 2.817E-2
1.460E-1
 3 360
39 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes-FCN1, LYZ, CTSS Top 200 Genes 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes-FCN1, LYZ, CTSS Top 200 Genes 1.620E-4 3.771E-3 2.817E-2
1.596E-1
 3 371
40 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes-S100A9, LYZ, S100A8 Top 200 Genes 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes-S100A9, LYZ, S100A8 Top 200 Genes 1.633E-4 3.771E-3 2.817E-2
1.609E-1
 3 372
41 10X Human 8K PBMC Dendritic Subtype Dendritic-CST3 HLA-DRA HLA-DRB1 Top 200 Genes 10X Human 8K PBMC Dendritic Subtype Dendritic-CST3 HLA-DRA HLA-DRB1 Top 200 Genes 1.646E-4 3.771E-3 2.817E-2
1.621E-1
 3 373
42 10X Human 8K PBMC B cells Subtype B cells-S100A8, LYZ, S100A9 Top 200 Genes 10X Human 8K PBMC B cells Subtype B cells-S100A8, LYZ, S100A9 Top 200 Genes 1.646E-4 3.771E-3 2.817E-2
1.621E-1
 3 373
43 10X Human 8K PBMC B cells CD79A-MS4A1-CD79B Subtype B cells CD79A-MS4A1-CD79B-B cells subclass-2 (S100A8, LYZ, S100A9) Top 200 Genes 10X Human 8K PBMC B cells CD79A-MS4A1-CD79B Subtype B cells CD79A-MS4A1-CD79B-B cells subclass-2 (S100A8, LYZ, S100A9) Top 200 Genes 1.646E-4 3.771E-3 2.817E-2
1.621E-1
 3 373
44 10X Human 8K PBMC B cells CD79A-MS4A1-CD79B Subtype B cells CD79A-MS4A1-CD79B-B cells subclass-1 (GZMB, LILRA4, PTGDS) Top 200 Genes 10X Human 8K PBMC B cells CD79A-MS4A1-CD79B Subtype B cells CD79A-MS4A1-CD79B-B cells subclass-1 (GZMB, LILRA4, PTGDS) Top 200 Genes 1.712E-4 3.777E-3 2.822E-2
1.686E-1
 3 378
45 10X Human 8K PBMC B cells Subtype B cells-GZMB, LILRA4, PTGDS Top 200 Genes 10X Human 8K PBMC B cells Subtype B cells-GZMB, LILRA4, PTGDS Top 200 Genes 1.726E-4 3.777E-3 2.822E-2
1.700E-1
 3 379
46 10X Human 8K PBMC Dendritic Subtype Dendritic-LILRA4, LRRC26, IL3RA Top 200 Genes 10X Human 8K PBMC Dendritic Subtype Dendritic-LILRA4, LRRC26, IL3RA Top 200 Genes 1.780E-4 3.811E-3 2.847E-2
1.753E-1
 3 383
47 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes- HLA-DRA, HLA-DPB1, HLA-DPA1 Top 200 Genes 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes- HLA-DRA, HLA-DPB1, HLA-DPA1 Top 200 Genes 1.835E-4 3.847E-3 2.874E-2
1.808E-1
 3 387
48 Lung Development Lungmap - Mouse FluidigmC1 Myeloid Overall Top 500 Genes Lung Development Lungmap - Mouse FluidigmC1 Myeloid Overall Top 500 Genes 1.979E-4 3.996E-3 2.985E-2
1.949E-1
 3 397
49 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Tumour PapRCC Renal cell carcinoma Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Tumour PapRCC Renal cell carcinoma Adult, Development, and Cancer types 1.988E-4 3.996E-3 2.985E-2
1.958E-1
 2 68
50 Lungmap Mouse Lung E16.5 Myeloid Lungmap Mouse Lung E16.5 Myeloid Lungmap CCHMC 2.224E-4 4.381E-3 3.273E-2
2.190E-1
 3 413
Show 45 more annotations

15: Computational [Display Chart] 3 input genes in category / 39 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13614 GNF2 MYD88 Neighborhood of MYD88 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.050E-4 4.096E-3 1.742E-2 4.096E-3 2 60
2 M11485 GNF2 LYN Neighborhood of LYN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.049E-3 4.663E-2
1.983E-1
3.139E-1
 1 27
3 M17314 GNF2 VAV1 Neighborhood of VAV1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.072E-2 4.663E-2
1.983E-1
4.182E-1
 1 36
4 M19427 GNF2 FOS Neighborhood of FOS MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.221E-2 4.663E-2
1.983E-1
4.760E-1
 1 41
5 M12582 GNF2 CD1D Neighborhood of CD1D MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.339E-2 4.663E-2
1.983E-1
5.223E-1
 1 45
6 M5267 GNF2 HLA-C Neighborhood of HLA-C MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.398E-2 4.663E-2
1.983E-1
5.454E-1
 1 47
7 M8373 GNF2 CD33 Neighborhood of CD33 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.546E-2 4.663E-2
1.983E-1
6.031E-1
 1 52
8 M17265 GNF2 PECAM1 Neighborhood of PECAM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.665E-2 4.663E-2
1.983E-1
6.492E-1
 1 56
9 M1250 GNF2 MCL1 Neighborhood of MCL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.694E-2 4.663E-2
1.983E-1
6.607E-1
 1 57
10 M356 GNF2 TNFRSF1B Neighborhood of TNFRSF1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.930E-2 4.663E-2
1.983E-1
7.529E-1
 1 65
11 M2320 MODULE 525 Genes in the cancer module 525. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.989E-2 4.663E-2
1.983E-1
7.759E-1
 1 67
12 M7032 GNF2 CARD15 Neighborhood of CARD15 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.078E-2 4.663E-2
1.983E-1
8.104E-1
 1 70
13 M8633 GNF2 STAT6 Neighborhood of STAT6 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.343E-2 4.663E-2
1.983E-1
9.138E-1
 1 79
14 M19525 MODULE 139 Genes in the cancer module 139. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.343E-2 4.663E-2
1.983E-1
9.138E-1
 1 79
15 M17322 MODULE 76 Inflammatory response. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.402E-2 4.663E-2
1.983E-1
9.367E-1
 1 81
16 M2032 MODULE 358 B lymphoma expression clusters. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.402E-2 4.663E-2
1.983E-1
9.367E-1
 1 81
17 M14338 GNF2 HCK Neighborhood of HCK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.784E-2 4.663E-2
1.983E-1
1.000E0
 1 94
18 M10511 MODULE 169 Immune response. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.872E-2 4.663E-2
1.983E-1
1.000E0
 1 97
19 M11185 MODULE 128 Genes in the cancer module 128. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.901E-2 4.663E-2
1.983E-1
1.000E0
 1 98
20 M10167 MODULE 97 Genes in the cancer module 97. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.930E-2 4.663E-2
1.983E-1
1.000E0
 1 99
21 M5974 MODULE 43 Energy pathways. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.930E-2 4.663E-2
1.983E-1
1.000E0
 1 99
22 M8286 MODULE 79 Genes in the cancer module 79. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.960E-2 4.663E-2
1.983E-1
1.000E0
 1 100
23 M444 MODULE 261 Genes in the cancer module 262. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.989E-2 4.663E-2
1.983E-1
1.000E0
 1 101
24 M11300 MODULE 182 Genes in the cancer module 182. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.989E-2 4.663E-2
1.983E-1
1.000E0
 1 101
25 M2944 MODULE 170 Immune response. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.989E-2 4.663E-2
1.983E-1
1.000E0
 1 101
26 M4396 GNF2 CASP1 Neighborhood of CASP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.281E-2 4.824E-2
2.052E-1
1.000E0
 1 111
27 M18856 MODULE 456 B lymphoma expression clusters. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.340E-2 4.824E-2
2.052E-1
1.000E0
 1 113
28 M8449 MODULE 180 Genes in the cancer module 180. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.544E-2 4.923E-2
2.094E-1
1.000E0
 1 120
29 M19044 MODULE 152 Oxidative phosphorylation and ATP synthesis. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.661E-2 4.923E-2
2.094E-1
1.000E0
 1 124
Show 24 more annotations

16: MicroRNA [Display Chart] 7 input genes in category / 133 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-204-5p:Functional MTI Functional MTI miRTarbase 6.274E-4 1.758E-2
9.616E-2
8.345E-2
 2 399
2 hsa-miR-148b-3p:Functional MTI Functional MTI miRTarbase 6.399E-4 1.758E-2
9.616E-2
8.511E-2
 2 403
3 hsa-miR-675:mirSVR lowEffct hsa-miR-675:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 6.686E-4 1.758E-2
9.616E-2
8.893E-2
 2 412
4 hsa-miR-1234:mirSVR lowEffct hsa-miR-1234:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 7.045E-4 1.758E-2
9.616E-2
9.370E-2
 2 423
5 hsa-miR-132*:mirSVR lowEffct hsa-miR-132*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 7.177E-4 1.758E-2
9.616E-2
9.546E-2
 2 427
6 hsa-miR-591:mirSVR highEffct hsa-miR-591:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.929E-4 1.758E-2
9.616E-2
1.055E-1
 2 449
7 hsa-miR-1282:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.130E-3 3.702E-2
2.025E-1
2.833E-1
 1 22
8 hsa-miR-3713:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.227E-3 3.702E-2
2.025E-1
2.961E-1
 1 23
9 hsa-miR-182-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 3.725E-2
2.038E-1
5.147E-1
 1 40
10 hsa-miR-99b:mirSVR highEffct hsa-miR-99b:mirSVR conserved highEffect-0.5 MicroRNA.org 4.449E-3 3.725E-2
2.038E-1
5.917E-1
 1 46
11 hsa-miR-6859-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 3.725E-2
2.038E-1
6.174E-1
 1 48
12 hsa-miR-4640-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 3.725E-2
2.038E-1
6.174E-1
 1 48
13 hsa-miR-99b-5p:Functional MTI Functional MTI miRTarbase 5.125E-3 3.725E-2
2.038E-1
6.816E-1
 1 53
14 hsa-miR-3912-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.125E-3 3.725E-2
2.038E-1
6.816E-1
 1 53
15 hsa-miR-4774-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 3.725E-2
2.038E-1
6.944E-1
 1 54
16 hsa-miR-3137:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.317E-3 3.725E-2
2.038E-1
7.072E-1
 1 55
17 hsa-miR-892a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 3.725E-2
2.038E-1
7.714E-1
 1 60
18 hsa-miR-2355-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 3.725E-2
2.038E-1
7.714E-1
 1 60
19 hsa-miR-6740-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.185E-3 3.725E-2
2.038E-1
8.226E-1
 1 64
20 hsa-miR-4646-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.571E-3 3.725E-2
2.038E-1
8.739E-1
 1 68
21 hsa-miR-4289:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.052E-3 3.725E-2
2.038E-1
9.380E-1
 1 73
22 hsa-miR-6812-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.149E-3 3.725E-2
2.038E-1
9.508E-1
 1 74
23 hsa-miR-6769a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.438E-3 3.725E-2
2.038E-1
9.892E-1
 1 77
24 hsa-miR-3152-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.726E-3 3.725E-2
2.038E-1
1.000E0
 1 80
25 hsa-miR-181a-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.919E-3 3.725E-2
2.038E-1
1.000E0
 1 82
26 hsa-miR-5087:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.015E-3 3.725E-2
2.038E-1
1.000E0
 1 83
27 hsa-miR-4464:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.592E-3 3.725E-2
2.038E-1
1.000E0
 1 89
28 hsa-miR-4711-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.592E-3 3.725E-2
2.038E-1
1.000E0
 1 89
29 hsa-miR-4748:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.689E-3 3.725E-2
2.038E-1
1.000E0
 1 90
30 hsa-miR-6509-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.689E-3 3.725E-2
2.038E-1
1.000E0
 1 90
31 hsa-miR-675:mirSVR highEffct hsa-miR-675:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.977E-3 3.725E-2
2.038E-1
1.000E0
 1 93
32 hsa-miR-20b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.169E-3 3.725E-2
2.038E-1
1.000E0
 1 95
33 hsa-miR-6795-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.266E-3 3.725E-2
2.038E-1
1.000E0
 1 96
34 hsa-miR-3616-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.842E-3 3.725E-2
2.038E-1
1.000E0
 1 102
35 hsa-miR-941:mirSVR highEffct hsa-miR-941:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.013E-2 3.725E-2
2.038E-1
1.000E0
 1 105
36 hsa-miR-496.1:TargetScan hsa-miR-496.1 TargetScan 1.061E-2 3.725E-2
2.038E-1
1.000E0
 1 110
37 hsa-miR-431-5p:TargetScan hsa-miR-431-5p TargetScan 1.071E-2 3.725E-2
2.038E-1
1.000E0
 1 111
38 hsa-miR-5007-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.080E-2 3.725E-2
2.038E-1
1.000E0
 1 112
39 hsa-miR-99a:mirSVR highEffct hsa-miR-99a:mirSVR conserved highEffect-0.5 MicroRNA.org 1.109E-2 3.725E-2
2.038E-1
1.000E0
 1 115
40 hsa-miR-100:mirSVR highEffct hsa-miR-100:mirSVR conserved highEffect-0.5 MicroRNA.org 1.138E-2 3.725E-2
2.038E-1
1.000E0
 1 118
41 hsa-miR-3196:mirSVR highEffct hsa-miR-3196:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.176E-2 3.725E-2
2.038E-1
1.000E0
 1 122
42 hsa-miR-1298-5p:TargetScan hsa-miR-1298-5p TargetScan 1.176E-2 3.725E-2
2.038E-1
1.000E0
 1 122
43 hsa-miR-3180-3p:mirSVR highEffct hsa-miR-3180-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.215E-2 3.757E-2
2.055E-1
1.000E0
 1 126
44 hsa-miR-99a-5p:Functional MTI Functional MTI miRTarbase 1.282E-2 3.874E-2
2.120E-1
1.000E0
 1 133
45 hsa-miR-219a-2-3p:TargetScan hsa-miR-219a-2-3p TargetScan 1.358E-2 3.982E-2
2.179E-1
1.000E0
 1 141
46 hsa-miR-500a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.397E-2 3.982E-2
2.179E-1
1.000E0
 1 145
47 hsa-miR-662:mirSVR highEffct hsa-miR-662:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.425E-2 3.982E-2
2.179E-1
1.000E0
 1 148
48 hsa-miR-1243:PITA hsa-miR-1243:PITA TOP PITA 1.492E-2 3.982E-2
2.179E-1
1.000E0
 1 155
49 hsa-miR-6826-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.511E-2 3.982E-2
2.179E-1
1.000E0
 1 157
50 hsa-miR-501-5p:Functional MTI Functional MTI miRTarbase 1.521E-2 3.982E-2
2.179E-1
1.000E0
 1 158
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 2294 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:D013481 Superoxides CTD 3.790E-17 8.695E-14 7.230E-13 8.695E-14 7 106
2 CID000128682 dihydroethidium Stitch 3.076E-14 3.529E-11 2.934E-10 7.057E-11 6 95
3 ctd:C545385 Mequindox CTD 9.605E-14 6.458E-11 5.370E-10 2.203E-10 5 33
4 CID000009214 biphenylene Stitch 1.126E-13 6.458E-11 5.370E-10 2.583E-10 5 34
5 CID000065410 hydroethidine Stitch 4.391E-13 2.015E-10 1.675E-9 1.007E-9 5 44
6 CID000002663 celiprolol Stitch 6.201E-13 2.123E-10 1.765E-9 1.423E-9 5 47
7 CID000010292 diphenyline Stitch 6.479E-13 2.123E-10 1.765E-9 1.486E-9 4 10
8 CID000002214 apocynin Stitch 1.870E-12 5.362E-10 4.459E-9 4.290E-9 6 186
9 CID000005005 AC1Q641C Stitch 2.613E-12 6.661E-10 5.539E-9 5.995E-9 5 62
10 CID000137994 tempol Stitch 5.324E-12 1.170E-9 9.731E-9 1.221E-8 6 221
11 ctd:C411602 dalcetrapib CTD 5.611E-12 1.170E-9 9.731E-9 1.287E-8 4 16
12 ctd:C081643 candesartan CTD 6.500E-12 1.243E-9 1.033E-8 1.491E-8 5 74
13 CID000003101 diphenyleneiodonium Stitch 7.145E-12 1.261E-9 1.048E-8 1.639E-8 6 232
14 ctd:C530884 anacetrapib CTD 1.195E-11 1.957E-9 1.628E-8 2.740E-8 4 19
15 CID000010638 luminol Stitch 1.489E-11 2.278E-9 1.894E-8 3.417E-8 5 87
16 CID011970116 NSC-708928 Stitch 1.763E-11 2.527E-9 2.101E-8 4.043E-8 3 3
17 CID000221534 NSC-6354 Stitch 1.982E-11 2.674E-9 2.224E-8 4.546E-8 5 92
18 CID000002830 coelenterazine Stitch 5.405E-11 6.744E-9 5.608E-8 1.240E-7 4 27
19 ctd:D017382 Reactive Oxygen Species CTD 5.585E-11 6.744E-9 5.608E-8 1.281E-7 6 326
20 CID000126741 L 012 Stitch 7.313E-11 8.388E-9 6.975E-8 1.678E-7 4 29
21 ctd:C056165 acetovanillone CTD 7.993E-11 8.732E-9 7.261E-8 1.834E-7 5 121
22 CID000150310 Selara Stitch 9.428E-11 9.830E-9 8.175E-8 2.163E-7 5 125
23 ctd:D000068577 Nebivolol CTD 2.271E-10 2.265E-8 1.883E-7 5.209E-7 4 38
24 ctd:D006852 Hydrochlorothiazide CTD 3.794E-10 3.626E-8 3.016E-7 8.704E-7 4 43
25 CID000520535 superoxide Stitch 6.501E-10 5.965E-8 4.960E-7 1.491E-6 6 490
26 CID000000977 oxygen Stitch 7.252E-10 6.399E-8 5.321E-7 1.664E-6 6 499
27 ctd:D017311 Amlodipine CTD 1.712E-9 1.454E-7 1.209E-6 3.926E-6 4 62
28 CID000001049 pyridine Stitch 2.484E-9 2.035E-7 1.692E-6 5.697E-6 5 239
29 CID000004644 oxypurinol Stitch 3.153E-9 2.494E-7 2.074E-6 7.233E-6 4 72
30 CID003658056 AC1MTZN9 Stitch 4.146E-9 3.132E-7 2.605E-6 9.510E-6 4 77
31 CID000005102 NSC115907 Stitch 4.251E-9 3.132E-7 2.605E-6 9.752E-6 5 266
32 CID000439171 Cytochrome c Stitch 4.369E-9 3.132E-7 2.605E-6 1.002E-5 4 78
33 CID011970115 NSC708927 Stitch 5.034E-9 3.499E-7 2.910E-6 1.155E-5 3 13
34 CID003083715 angiotensin Stitch 5.699E-9 3.845E-7 3.197E-6 1.307E-5 5 282
35 CID000065099 lucigenin Stitch 5.906E-9 3.871E-7 3.219E-6 1.355E-5 4 84
36 CID000104913 DCFH-DA Stitch 6.499E-9 4.141E-7 3.444E-6 1.491E-5 4 86
37 CID000158781 olmesartan Stitch 8.175E-9 5.069E-7 4.215E-6 1.875E-5 4 91
38 ctd:C400084 4-chlorobenzyltetrahydroberberine CTD 9.853E-9 5.948E-7 4.946E-6 2.260E-5 3 16
39 CID000065124 nitrotyrosine Stitch 1.016E-8 5.974E-7 4.968E-6 2.330E-5 4 96
40 ctd:C084178 telmisartan CTD 1.059E-8 6.074E-7 5.051E-6 2.430E-5 4 97
41 CID000083786 1 Tc1 Stitch 1.198E-8 6.705E-7 5.575E-6 2.749E-5 4 100
42 CID000000928 reduced diphosphopyridine nucleotide Stitch 1.498E-8 8.181E-7 6.803E-6 3.436E-5 5 342
43 CID000000703 flavin adenine dinucleotide sodium Stitch 1.831E-8 9.767E-7 8.122E-6 4.200E-5 5 356
44 ctd:C434003 3-(4-methylphenylsulfonyl)-2-propenenitrile CTD 1.965E-8 1.024E-6 8.519E-6 4.508E-5 4 113
45 CID004475485 AC1NAE4O Stitch 2.109E-8 1.075E-6 8.942E-6 4.839E-5 4 115
46 CID000104806 peroxynitrite Stitch 2.312E-8 1.153E-6 9.587E-6 5.303E-5 5 373
47 CID000003961 losartan Stitch 2.471E-8 1.206E-6 1.003E-5 5.668E-5 5 378
48 ctd:C093642 SB 203580 CTD 2.815E-8 1.346E-6 1.119E-5 6.458E-5 5 388
49 ctd:D019308 Palmitic Acid CTD 2.954E-8 1.383E-6 1.150E-5 6.776E-5 4 125
50 ctd:D056604 Grape Seed Extract CTD 3.557E-8 1.574E-6 1.309E-5 8.161E-5 3 24
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 236 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0020443 Hypercholesterolemia DisGeNET Curated 1.157E-8 1.825E-6 1.103E-5 2.730E-6 5 231
2 C0018203 Chronic granulomatous disease DisGeNET Curated 1.547E-8 1.825E-6 1.103E-5 3.650E-6 4 76
3 C1844390 Deficiency or absence of cytochrome b(-245) DisGeNET Curated 1.599E-7 8.087E-6 4.887E-5 3.775E-5 2 2
4 C0014836 Escherichia coli Infections DisGeNET Curated 1.994E-7 8.087E-6 4.887E-5 4.706E-5 3 30
5 C1844394 Decreased activity of NADPH oxidase DisGeNET Curated 4.797E-7 8.087E-6 4.887E-5 1.132E-4 2 3
6 C1844380 Hepatic abscesses due to immunodeficiency DisGeNET Curated 4.797E-7 8.087E-6 4.887E-5 1.132E-4 2 3
7 C2931299 ZAP70 deficiency DisGeNET Curated 4.797E-7 8.087E-6 4.887E-5 1.132E-4 2 3
8 C4021752 Recurrent Aspergillus infections DisGeNET Curated 4.797E-7 8.087E-6 4.887E-5 1.132E-4 2 3
9 C4280805 Negative nitroblue tetrazolium reduction test DisGeNET Curated 4.797E-7 8.087E-6 4.887E-5 1.132E-4 2 3
10 C4025682 Recurrent Serratia marcescens infections DisGeNET Curated 4.797E-7 8.087E-6 4.887E-5 1.132E-4 2 3
11 C4025673 Recurrent Burkholderia cepacia infections DisGeNET Curated 4.797E-7 8.087E-6 4.887E-5 1.132E-4 2 3
12 C1844382 Cellulitis due to immunodeficiency DisGeNET Curated 4.797E-7 8.087E-6 4.887E-5 1.132E-4 2 3
13 C1844385 Absence of bactericidal oxidative 'respiratory burst' in phagocytes DisGeNET Curated 4.797E-7 8.087E-6 4.887E-5 1.132E-4 2 3
14 C4021751 Recurrent Klebsiella infections DisGeNET Curated 4.797E-7 8.087E-6 4.887E-5 1.132E-4 2 3
15 C1844376 Granulomatous Disease, Chronic, X-Linked DisGeNET Curated 6.950E-7 1.093E-5 6.608E-5 1.640E-4 3 45
16 C3806330 Osteomyelitis due to immunodeficiency DisGeNET Curated 9.593E-7 1.332E-5 8.048E-5 2.264E-4 2 4
17 C2673462 Recurrent Staphylococcus aureus infections DisGeNET Curated 9.593E-7 1.332E-5 8.048E-5 2.264E-4 2 4
18 C0149770 Rectal abscess DisGeNET Curated 1.598E-6 1.985E-5 1.200E-4 3.772E-4 2 5
19 C0267566 Perirectal abscess DisGeNET Curated 1.598E-6 1.985E-5 1.200E-4 3.772E-4 2 5
20 C0856169 Endothelial dysfunction DisGeNET BeFree 2.284E-6 2.694E-5 1.628E-4 5.391E-4 4 263
21 C3661525 Autosomal Recessive Chronic Granulomatous Disease DisGeNET BeFree 2.397E-6 2.694E-5 1.628E-4 5.657E-4 2 6
22 C1835686 Recurrent bacterial skin infections DisGeNET Curated 4.473E-6 4.798E-5 2.900E-4 1.056E-3 2 8
23 C0521173 Granulomatosis DisGeNET Curated 5.750E-6 5.900E-5 3.565E-4 1.357E-3 2 9
24 C0022661 Kidney Failure, Chronic DisGeNET Curated 7.865E-6 7.675E-5 4.638E-4 1.856E-3 4 359
25 C0876973 Infectious disease of lung DisGeNET Curated 8.568E-6 7.675E-5 4.638E-4 2.022E-3 3 103
26 C0520743 Mediastinal lymphadenopathy DisGeNET Curated 8.781E-6 7.675E-5 4.638E-4 2.072E-3 2 11
27 C1846006 Ectodermal dysplasia, hypohidrotic, with immune deficiency DisGeNET Curated 8.781E-6 7.675E-5 4.638E-4 2.072E-3 2 11
28 C0011853 Diabetes Mellitus, Experimental DisGeNET Curated 9.609E-6 8.099E-5 4.895E-4 2.268E-3 3 107
29 C0427515 Neutrophil abnormality DisGeNET Curated 3.346E-5 2.723E-4 1.645E-3 7.896E-3 2 21
30 C0024205 Lymphadenitis DisGeNET Curated 4.029E-5 3.170E-4 1.915E-3 9.509E-3 2 23
31 C1859117 Recurrent pulmonary infections DisGeNET Curated 6.458E-5 4.763E-4 2.878E-3 1.524E-2 2 29
32 C0748140 Multiple pulmonary infections DisGeNET Curated 6.458E-5 4.763E-4 2.878E-3 1.524E-2 2 29
33 C0694550 Recurrent pneumonia DisGeNET Curated 7.393E-5 5.287E-4 3.195E-3 1.745E-2 2 31
34 C0398689 Hyper-IgM Immunodeficiency Syndrome, Type 1 DisGeNET Curated 7.885E-5 5.473E-4 3.307E-3 1.861E-2 2 32
35 C0030469 Paranasal Sinus Diseases DisGeNET Curated 8.914E-5 6.011E-4 3.632E-3 2.104E-2 2 34
36 C1565489 Renal Insufficiency DisGeNET Curated 1.035E-4 6.746E-4 4.077E-3 2.443E-2 3 237
37 C0040588 Tracheoesophageal Fistula DisGeNET Curated 1.058E-4 6.746E-4 4.077E-3 2.496E-2 2 37
38 C0034194 Pyloric Stenosis DisGeNET Curated 1.116E-4 6.932E-4 4.189E-3 2.634E-2 2 38
39 C0549463 X-Linked Lymphoproliferative Disorder DisGeNET Curated 1.366E-4 8.244E-4 4.982E-3 3.223E-2 2 42
40 C0751955 Brain Infarction DisGeNET Curated 1.432E-4 8.244E-4 4.982E-3 3.380E-2 2 43
41 C1842774 Hyperpigmented macules DisGeNET Curated 1.432E-4 8.244E-4 4.982E-3 3.380E-2 2 43
42 C0276447 Rhinovirus infection DisGeNET BeFree 1.641E-4 9.218E-4 5.571E-3 3.872E-2 2 46
43 C0085580 Essential Hypertension DisGeNET Curated 1.769E-4 9.711E-4 5.869E-3 4.176E-2 3 284
44 C0037199 Sinusitis DisGeNET Curated 1.940E-4 1.041E-3 6.288E-3 4.579E-2 2 50
45 C0151718 Hypocholesterolemia DisGeNET Curated 2.181E-4 1.144E-3 6.912E-3
5.147E-2
 2 53
46 C0349506 Photosensitivity of skin DisGeNET Curated 2.349E-4 1.205E-3 7.284E-3
5.545E-2
 2 55
47 C0221026 X-linked agammaglobulinemia DisGeNET Curated 2.436E-4 1.223E-3 7.392E-3
5.749E-2
 2 56
48 C0497156 Lymphadenopathy DisGeNET Curated 3.184E-4 1.550E-3 9.367E-3
7.513E-2
 2 64
49 C0852949 Arteriopathic disease DisGeNET BeFree 3.284E-4 1.550E-3 9.367E-3
7.750E-2
 2 65
50 C0029882 Otitis Media DisGeNET Curated 3.284E-4 1.550E-3 9.367E-3
7.750E-2
 2 65
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