Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc283_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 22 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 2.940E-9 6.469E-8 2.387E-7 6.469E-8 5 259
2 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 1.472E-8 8.741E-8 3.226E-7 3.239E-7 5 357
3 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 1.645E-8 8.741E-8 3.226E-7 3.619E-7 5 365
4 GO:0042826 histone deacetylase binding 1.963E-8 8.741E-8 3.226E-7 4.318E-7 4 114
5 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 1.986E-8 8.741E-8 3.226E-7 4.370E-7 5 379
6 GO:0000987 proximal promoter sequence-specific DNA binding 2.538E-8 9.306E-8 3.435E-7 5.583E-7 5 398
7 GO:0033613 activating transcription factor binding 6.601E-7 2.074E-6 7.657E-6 1.452E-5 3 61
8 GO:0071837 HMG box domain binding 2.173E-5 5.976E-5 2.206E-4 4.781E-4 2 23
9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 4.548E-4 1.112E-3 4.103E-3 1.000E-2 2 104
10 GO:0003680 AT DNA binding 2.891E-3 6.359E-3 2.347E-2
6.359E-2
 1 9
11 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding 4.494E-3 8.987E-3 3.317E-2
9.886E-2
 1 14
12 GO:0035198 miRNA binding 5.454E-3 9.999E-3 3.691E-2
1.200E-1
 1 17
13 GO:0035035 histone acetyltransferase binding 9.608E-3 1.510E-2
5.573E-2
2.114E-1
 1 30
14 GO:0001205 distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific 9.608E-3 1.510E-2
5.573E-2
2.114E-1
 1 30
15 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 2.262E-2 3.317E-2
1.224E-1
4.975E-1
 1 71
16 GO:0046332 SMAD binding 2.451E-2 3.370E-2
1.244E-1
5.391E-1
 1 77
17 GO:0001158 enhancer sequence-specific DNA binding 2.954E-2 3.822E-2
1.411E-1
6.498E-1
 1 93
18 GO:0035326 enhancer binding 3.361E-2 4.107E-2
1.516E-1
7.393E-1
 1 106
19 GO:0001046 core promoter sequence-specific DNA binding 3.642E-2 4.109E-2
1.516E-1
8.011E-1
 1 115
20 GO:0001085 RNA polymerase II transcription factor binding 3.735E-2 4.109E-2
1.516E-1
8.217E-1
 1 118
Show 15 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 383 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001958 endochondral ossification 8.325E-8 1.594E-5 1.040E-4 3.188E-5 3 31
2 GO:0036075 replacement ossification 8.325E-8 1.594E-5 1.040E-4 3.188E-5 3 31
3 GO:0060350 endochondral bone morphogenesis 4.845E-7 6.185E-5 4.037E-4 1.855E-4 3 55
4 GO:0060021 roof of mouth development 2.160E-6 1.768E-4 1.154E-3 8.274E-4 3 90
5 GO:0060349 bone morphogenesis 2.309E-6 1.768E-4 1.154E-3 8.842E-4 3 92
6 GO:0007517 muscle organ development 3.194E-6 2.039E-4 1.331E-3 1.223E-3 4 405
7 GO:0055012 ventricular cardiac muscle cell differentiation 1.639E-5 8.970E-4 5.854E-3 6.279E-3 2 20
8 GO:0060348 bone development 2.142E-5 1.026E-3 6.693E-3 8.204E-3 3 193
9 GO:0001649 osteoblast differentiation 3.299E-5 1.404E-3 9.162E-3 1.264E-2 3 223
10 GO:0048705 skeletal system morphogenesis 3.665E-5 1.404E-3 9.162E-3 1.404E-2 3 231
11 GO:0050678 regulation of epithelial cell proliferation 9.945E-5 3.263E-3 2.129E-2 3.809E-2 3 323
12 GO:0048562 embryonic organ morphogenesis 1.022E-4 3.263E-3 2.129E-2 3.915E-2 3 326
13 GO:0071277 cellular response to calcium ion 1.183E-4 3.486E-3 2.275E-2 4.532E-2 2 53
14 GO:0030239 myofibril assembly 1.570E-4 4.154E-3 2.711E-2
6.012E-2
 2 61
15 GO:0050673 epithelial cell proliferation 1.752E-4 4.154E-3 2.711E-2
6.712E-2
 3 391
16 GO:0014706 striated muscle tissue development 1.833E-4 4.154E-3 2.711E-2
7.021E-2
 3 397
17 GO:0001503 ossification 1.931E-4 4.154E-3 2.711E-2
7.394E-2
 3 404
18 GO:0045669 positive regulation of osteoblast differentiation 1.952E-4 4.154E-3 2.711E-2
7.476E-2
 2 68
19 GO:0060537 muscle tissue development 2.090E-4 4.213E-3 2.750E-2
8.005E-2
 3 415
20 GO:0035914 skeletal muscle cell differentiation 2.504E-4 4.795E-3 3.130E-2
9.591E-2
 2 77
21 GO:0048568 embryonic organ development 3.192E-4 4.936E-3 3.221E-2
1.222E-1
 3 479
22 GO:0003172 sinoatrial valve development 3.222E-4 4.936E-3 3.221E-2
1.234E-1
 1 1
23 GO:0003185 sinoatrial valve morphogenesis 3.222E-4 4.936E-3 3.221E-2
1.234E-1
 1 1
24 GO:0003138 primary heart field specification 3.222E-4 4.936E-3 3.221E-2
1.234E-1
 1 1
25 GO:0060025 regulation of synaptic activity 3.222E-4 4.936E-3 3.221E-2
1.234E-1
 1 1
26 GO:0051149 positive regulation of muscle cell differentiation 3.811E-4 5.614E-3 3.664E-2
1.460E-1
 2 95
27 GO:0045778 positive regulation of ossification 4.138E-4 5.870E-3 3.831E-2
1.585E-1
 2 99
28 GO:0002062 chondrocyte differentiation 4.654E-4 6.366E-3 4.155E-2
1.782E-1
 2 105
29 GO:0042472 inner ear morphogenesis 5.014E-4 6.622E-3 4.322E-2
1.920E-1
 2 109
30 GO:0055007 cardiac muscle cell differentiation 5.774E-4 7.372E-3 4.811E-2
2.212E-1
 2 117
31 GO:0045667 regulation of osteoblast differentiation 6.379E-4 7.711E-3
5.033E-2
2.443E-1
 2 123
32 GO:0007521 muscle cell fate determination 6.443E-4 7.711E-3
5.033E-2
2.468E-1
 1 2
33 GO:0051592 response to calcium ion 6.692E-4 7.767E-3
5.069E-2
2.563E-1
 2 126
34 GO:0042471 ear morphogenesis 7.341E-4 8.270E-3
5.397E-2
2.812E-1
 2 132
35 GO:0030326 embryonic limb morphogenesis 8.607E-4 9.027E-3
5.891E-2
3.297E-1
 2 143
36 GO:0035113 embryonic appendage morphogenesis 8.607E-4 9.027E-3
5.891E-2
3.297E-1
 2 143
37 GO:0035051 cardiocyte differentiation 8.848E-4 9.027E-3
5.891E-2
3.389E-1
 2 145
38 GO:0071248 cellular response to metal ion 9.590E-4 9.027E-3
5.891E-2
3.673E-1
 2 151
39 GO:0055005 ventricular cardiac myofibril assembly 9.663E-4 9.027E-3
5.891E-2
3.701E-1
 1 3
40 GO:2000111 positive regulation of macrophage apoptotic process 9.663E-4 9.027E-3
5.891E-2
3.701E-1
 1 3
41 GO:0060166 olfactory pit development 9.663E-4 9.027E-3
5.891E-2
3.701E-1
 1 3
42 GO:0031032 actomyosin structure organization 1.103E-3 9.758E-3
6.368E-2
4.223E-1
 2 162
43 GO:0055002 striated muscle cell development 1.157E-3 9.758E-3
6.368E-2
4.432E-1
 2 166
44 GO:0035107 appendage morphogenesis 1.171E-3 9.758E-3
6.368E-2
4.485E-1
 2 167
45 GO:0035108 limb morphogenesis 1.171E-3 9.758E-3
6.368E-2
4.485E-1
 2 167
46 GO:0051147 regulation of muscle cell differentiation 1.241E-3 9.758E-3
6.368E-2
4.755E-1
 2 172
47 GO:0050679 positive regulation of epithelial cell proliferation 1.285E-3 9.758E-3
6.368E-2
4.921E-1
 2 175
48 GO:0035984 cellular response to trichostatin A 1.288E-3 9.758E-3
6.368E-2
4.934E-1
 1 4
49 GO:0035983 response to trichostatin A 1.288E-3 9.758E-3
6.368E-2
4.934E-1
 1 4
50 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis 1.288E-3 9.758E-3
6.368E-2
4.934E-1
 1 4
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000790 nuclear chromatin 4.130E-3 1.589E-2 3.893E-2 2.478E-2 2 324
2 GO:0005667 transcription factor complex 5.297E-3 1.589E-2 3.893E-2 3.178E-2 2 368
3 GO:0000785 chromatin 9.128E-3 1.826E-2 4.473E-2
5.477E-2
 2 487

4: Human Phenotype [Display Chart] 4 input genes in category / 128 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004050 Absent hand 6.475E-5 8.288E-3 4.503E-2 8.288E-3 2 16
2 HP:0012165 Oligodactyly 1.888E-4 1.208E-2
6.565E-2
 2.417E-2 2 27
3 HP:0000526 Aniridia 3.572E-4 1.524E-2
8.281E-2
 4.572E-2 2 37
4 HP:0001171 Split hand 8.216E-4 1.905E-2
1.035E-1
1.052E-1
 2 56
5 HP:0100257 Ectrodactyly 8.813E-4 1.905E-2
1.035E-1
1.128E-1
 2 58
6 HP:0001159 Syndactyly 8.931E-4 1.905E-2
1.035E-1
1.143E-1
 3 291
7 HP:0006913 Frontal cortical atrophy 1.699E-3 3.107E-2
1.688E-1
2.175E-1
 1 2
8 HP:0008053 Aplasia/Hypoplasia of the iris 2.765E-3 3.932E-2
2.136E-1
3.539E-1
 2 103
9 HP:0008055 Aplasia/Hypoplasia affecting the uvea 2.765E-3 3.932E-2
2.136E-1
3.539E-1
 2 103
Show 4 more annotations

5: Mouse Phenotype [Display Chart] 6 input genes in category / 450 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004596 abnormal mandibular angle morphology 2.178E-7 5.284E-5 3.533E-4 9.802E-5 3 24
2 MP:0004595 abnormal mandibular condyloid process morphology 2.475E-7 5.284E-5 3.533E-4 1.114E-4 3 25
3 MP:0004594 abnormal mandibular coronoid process morphology 3.522E-7 5.284E-5 3.533E-4 1.585E-4 3 28
4 MP:0010150 abnormal mandibular ramus morphology 7.664E-7 8.622E-5 5.766E-4 3.449E-4 3 36
5 MP:0002919 enhanced paired-pulse facilitation 1.231E-6 1.079E-4 7.214E-4 5.538E-4 3 42
6 MP:0009918 abnormal stylohyoid ligament morphology 1.678E-6 1.079E-4 7.214E-4 7.551E-4 2 4
7 MP:0030259 mandibular condyloid process hypoplasia 1.678E-6 1.079E-4 7.214E-4 7.551E-4 2 4
8 MP:0000030 abnormal tympanic ring morphology 2.364E-6 1.258E-4 8.414E-4 1.064E-3 3 52
9 MP:0008278 failure of sternum ossification 2.796E-6 1.258E-4 8.414E-4 1.258E-3 2 5
10 MP:0030299 lower jaw to upper jaw transformation 2.796E-6 1.258E-4 8.414E-4 1.258E-3 2 5
11 MP:0005587 abnormal Meckel's cartilage morphology 3.472E-6 1.420E-4 9.498E-4 1.562E-3 3 59
12 MP:0030298 jaw transformation 5.868E-6 2.201E-4 1.472E-3 2.641E-3 2 7
13 MP:0002918 abnormal paired-pulse facilitation 6.900E-6 2.347E-4 1.569E-3 3.105E-3 3 74
14 MP:0003800 monodactyly 7.823E-6 2.347E-4 1.569E-3 3.520E-3 2 8
15 MP:0005230 ectrodactyly 7.823E-6 2.347E-4 1.569E-3 3.520E-3 2 8
16 MP:0005272 abnormal temporal bone morphology 8.734E-6 2.457E-4 1.643E-3 3.930E-3 3 80
17 MP:0010939 abnormal mandibular prominence morphology 1.006E-5 2.662E-4 1.780E-3 4.525E-3 2 9
18 MP:0008275 failure of endochondral bone ossification 1.257E-5 3.141E-4 2.101E-3 5.654E-3 2 10
19 MP:0004439 absent Meckel's cartilage 1.535E-5 3.636E-4 2.432E-3 6.909E-3 2 11
20 MP:0030258 small mandibular condyloid process 2.538E-5 5.711E-4 3.820E-3 1.142E-2 2 14
21 MP:0000049 abnormal middle ear morphology 2.673E-5 5.729E-4 3.831E-3 1.203E-2 3 116
22 MP:0009914 abnormal hyoid bone lesser horn morphology 2.928E-5 5.989E-4 4.005E-3 1.318E-2 2 15
23 MP:0004912 absent mandibular coronoid process 3.346E-5 6.546E-4 4.378E-3 1.506E-2 2 16
24 MP:0008380 abnormal gonial bone morphology 3.791E-5 7.108E-4 4.753E-3 1.706E-2 2 17
25 MP:0030383 small presphenoid bone 5.292E-5 9.159E-4 6.125E-3 2.381E-2 2 20
26 MP:0004453 abnormal pterygoid bone morphology 5.292E-5 9.159E-4 6.125E-3 2.381E-2 2 20
27 MP:0008274 failure of bone ossification 5.847E-5 9.746E-4 6.517E-3 2.631E-2 2 21
28 MP:0003138 absent tympanic ring 6.430E-5 1.026E-3 6.863E-3 2.894E-2 2 22
29 MP:0004592 small mandible 6.614E-5 1.026E-3 6.863E-3 2.976E-2 3 157
30 MP:0006020 decreased tympanic ring size 7.041E-5 1.056E-3 7.063E-3 3.168E-2 2 23
31 MP:0030026 small Meckel's cartilage 7.679E-5 1.115E-3 7.455E-3 3.456E-2 2 24
32 MP:0001890 anencephaly 9.038E-5 1.271E-3 8.499E-3 4.067E-2 2 26
33 MP:0002260 abnormal thyroid cartilage morphology 9.758E-5 1.331E-3 8.899E-3 4.391E-2 2 27
34 MP:0003203 increased neuron apoptosis 1.223E-4 1.619E-3 1.083E-2
5.505E-2
 3 193
35 MP:0004726 abnormal nasal capsule morphology 1.466E-4 1.884E-3 1.260E-2
6.595E-2
 2 33
36 MP:0002544 brachydactyly 1.557E-4 1.893E-3 1.266E-2
7.006E-2
 2 34
37 MP:0004452 abnormal pterygoid process morphology 1.557E-4 1.893E-3 1.266E-2
7.006E-2
 2 34
38 MP:0003235 abnormal alisphenoid bone morphology 1.651E-4 1.955E-3 1.307E-2
7.428E-2
 2 35
39 MP:0004448 abnormal presphenoid bone morphology 1.747E-4 2.016E-3 1.348E-2
7.863E-2
 2 36
40 MP:0002256 abnormal laryngeal cartilage morphology 1.847E-4 2.027E-3 1.356E-2
8.311E-2
 2 37
41 MP:0004423 abnormal temporal bone squamous part morphology 1.847E-4 2.027E-3 1.356E-2
8.311E-2
 2 37
42 MP:0000443 abnormal snout morphology 1.904E-4 2.040E-3 1.364E-2
8.567E-2
 3 224
43 MP:0000458 abnormal mandible morphology 2.059E-4 2.155E-3 1.441E-2
9.265E-2
 3 230
44 MP:0003072 abnormal metatarsal bone morphology 2.271E-4 2.278E-3 1.524E-2
1.022E-1
 2 41
45 MP:0002207 abnormal long term potentiation 2.278E-4 2.278E-3 1.524E-2
1.025E-1
 3 238
46 MP:0005270 abnormal zygomatic bone morphology 2.500E-4 2.446E-3 1.636E-2
1.125E-1
 2 43
47 MP:0009409 abnormal skeletal muscle fiber type ratio 2.618E-4 2.507E-3 1.677E-2
1.178E-1
 2 44
48 MP:0005504 abnormal ligament morphology 2.740E-4 2.568E-3 1.718E-2
1.233E-1
 2 45
49 MP:0000029 abnormal malleus morphology 2.863E-4 2.630E-3 1.759E-2
1.289E-1
 2 46
50 MP:0002249 abnormal larynx morphology 3.119E-4 2.807E-3 1.877E-2
1.404E-1
 2 48
Show 45 more annotations

6: Domain [Display Chart] 6 input genes in category / 20 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR033896 MADS MEF2-like InterPro 2.923E-15 5.846E-14 2.103E-13 5.846E-14 4 4
2 PS00350 MADS BOX 1 PROSITE 4.384E-14 1.753E-13 6.309E-13 8.767E-13 4 6
3 PS50066 MADS BOX 2 PROSITE 4.384E-14 1.753E-13 6.309E-13 8.767E-13 4 6
4 SM00432 MADS SMART 4.384E-14 1.753E-13 6.309E-13 8.767E-13 4 6
5 PF00319 SRF-TF Pfam 4.384E-14 1.753E-13 6.309E-13 8.767E-13 4 6
6 IPR002100 TF MADSbox InterPro 1.023E-13 3.409E-13 1.227E-12 2.046E-12 4 7
7 IPR022102 HJURP C InterPro 7.300E-11 1.825E-10 6.565E-10 1.460E-9 3 4
8 PF12347 HJURP C Pfam 7.300E-11 1.825E-10 6.565E-10 1.460E-9 3 4
9 IPR000047 HTH motif InterPro 1.986E-4 4.414E-4 1.588E-3 3.972E-3 2 69
10 IPR020479 Homeobox metazoa InterPro 3.381E-4 6.761E-4 2.433E-3 6.761E-3 2 90
11 IPR022135 Distal-less N InterPro 9.605E-4 1.601E-3 5.759E-3 1.921E-2 1 3
12 PF12413 DLL N Pfam 9.605E-4 1.601E-3 5.759E-3 1.921E-2 1 3
13 IPR017970 Homeobox CS InterPro 1.432E-3 2.204E-3 7.929E-3 2.865E-2 2 186
14 PF00046 Homeobox Pfam 2.254E-3 2.611E-3 9.395E-3 4.508E-2 2 234
15 PS00027 HOMEOBOX 1 PROSITE 2.292E-3 2.611E-3 9.395E-3 4.585E-2 2 236
16 SM00389 HOX SMART 2.312E-3 2.611E-3 9.395E-3 4.623E-2 2 237
17 PS50071 HOMEOBOX 2 PROSITE 2.350E-3 2.611E-3 9.395E-3 4.700E-2 2 239
18 IPR001356 Homeobox dom InterPro 2.350E-3 2.611E-3 9.395E-3 4.700E-2 2 239
19 1.10.10.60 - Gene3D 3.277E-3 3.449E-3 1.241E-2
6.553E-2
 2 283
20 IPR009057 Homeodomain-like InterPro 4.480E-3 4.480E-3 1.612E-2
8.960E-2
 2 332
Show 15 more annotations

7: Pathway [Display Chart] 5 input genes in category / 56 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270336 CDO in myogenesis BioSystems: REACTOME 1.185E-10 3.318E-9 1.530E-8 6.636E-9 4 29
2 1270335 Myogenesis BioSystems: REACTOME 1.185E-10 3.318E-9 1.530E-8 6.636E-9 4 29
3 P05918 p38 MAPK pathway PantherDB 2.937E-10 5.483E-9 2.529E-8 1.645E-8 4 36
4 M16811 Role of Erk5 in Neuronal Survival MSigDB C2 BIOCARTA (v6.0) 2.533E-8 3.546E-7 1.635E-6 1.419E-6 3 18
5 M15181 Regulation of PGC-1a MSigDB C2 BIOCARTA (v6.0) 6.279E-8 6.687E-7 3.084E-6 3.516E-6 3 24
6 1492886 Apelin signaling pathway BioSystems: KEGG 7.165E-8 6.687E-7 3.084E-6 4.012E-6 4 138
7 M1547 Control of skeletal myogenesis by HDAC and calcium/calmodulin-dependent kinase (CaMK) MSigDB C2 BIOCARTA (v6.0) 1.259E-7 9.813E-7 4.525E-6 7.048E-6 3 30
8 983748 cGMP-PKG signaling pathway BioSystems: KEGG 1.402E-7 9.813E-7 4.525E-6 7.850E-6 4 163
9 M14899 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling MSigDB C2 BIOCARTA (v6.0) 1.854E-7 1.154E-6 5.320E-6 1.038E-5 3 34
10 M862 p38 MAPK Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 3.059E-7 1.713E-6 7.899E-6 1.713E-5 3 40
11 M13863 MAPKinase Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 3.263E-6 1.661E-5 7.661E-5 1.827E-4 3 87
12 1269215 ERK/MAPK targets BioSystems: REACTOME 2.971E-5 1.387E-4 6.394E-4 1.664E-3 2 22
13 1269477 Nuclear Events (kinase and transcription factor activation) BioSystems: REACTOME 3.857E-5 1.661E-4 7.662E-4 2.160E-3 2 25
14 1269214 MAPK targets/ Nuclear events mediated by MAP kinases BioSystems: REACTOME 5.972E-5 2.389E-4 1.102E-3 3.345E-3 2 31
15 138012 Signaling mediated by p38-alpha and p38-beta BioSystems: Pathway Interaction Database 7.637E-5 2.851E-4 1.315E-3 4.277E-3 2 35
16 1268841 Transcriptional activation of mitochondrial biogenesis BioSystems: REACTOME 1.269E-4 4.369E-4 2.015E-3 7.105E-3 2 45
17 P00046 Oxidative stress response PantherDB 1.326E-4 4.369E-4 2.015E-3 7.426E-3 2 46
18 1268839 Mitochondrial biogenesis BioSystems: REACTOME 1.831E-4 5.697E-4 2.627E-3 1.025E-2 2 54
19 1269211 MAP kinase activation in TLR cascade BioSystems: REACTOME 2.576E-4 7.591E-4 3.501E-3 1.442E-2 2 64
20 1269871 Circadian Clock BioSystems: REACTOME 3.171E-4 8.880E-4 4.095E-3 1.776E-2 2 71
21 1269207 MyD88 cascade initiated on plasma membrane BioSystems: REACTOME 4.439E-4 1.015E-3 4.681E-3 2.486E-2 2 84
22 1269206 Toll Like Receptor 10 (TLR10) Cascade BioSystems: REACTOME 4.439E-4 1.015E-3 4.681E-3 2.486E-2 2 84
23 1269226 Toll Like Receptor 5 (TLR5) Cascade BioSystems: REACTOME 4.439E-4 1.015E-3 4.681E-3 2.486E-2 2 84
24 1269229 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation BioSystems: REACTOME 5.209E-4 1.015E-3 4.681E-3 2.917E-2 2 91
25 1269228 MyD88 dependent cascade initiated on endosome BioSystems: REACTOME 5.440E-4 1.015E-3 4.681E-3 3.046E-2 2 93
26 1269227 Toll Like Receptor 7/8 (TLR7/8) Cascade BioSystems: REACTOME 5.440E-4 1.015E-3 4.681E-3 3.046E-2 2 93
27 1269239 Toll Like Receptor TLR1:TLR2 Cascade BioSystems: REACTOME 5.676E-4 1.015E-3 4.681E-3 3.179E-2 2 95
28 1269240 Toll Like Receptor TLR6:TLR2 Cascade BioSystems: REACTOME 5.676E-4 1.015E-3 4.681E-3 3.179E-2 2 95
29 1269237 MyD88:Mal cascade initiated on plasma membrane BioSystems: REACTOME 5.676E-4 1.015E-3 4.681E-3 3.179E-2 2 95
30 1269238 Toll Like Receptor 2 (TLR2) Cascade BioSystems: REACTOME 5.676E-4 1.015E-3 4.681E-3 3.179E-2 2 95
31 1269233 Toll Like Receptor 9 (TLR9) Cascade BioSystems: REACTOME 5.917E-4 1.015E-3 4.681E-3 3.313E-2 2 97
32 1269220 MyD88-independent TLR3/TLR4 cascade BioSystems: REACTOME 6.163E-4 1.015E-3 4.681E-3 3.451E-2 2 99
33 1269221 TRIF-mediated TLR3/TLR4 signaling BioSystems: REACTOME 6.163E-4 1.015E-3 4.681E-3 3.451E-2 2 99
34 1269219 Toll Like Receptor 3 (TLR3) Cascade BioSystems: REACTOME 6.163E-4 1.015E-3 4.681E-3 3.451E-2 2 99
35 1269236 Activated TLR4 signalling BioSystems: REACTOME 8.306E-4 1.329E-3 6.129E-3 4.651E-2 2 115
36 1269234 Toll Like Receptor 4 (TLR4) Cascade BioSystems: REACTOME 9.961E-4 1.549E-3 7.145E-3
5.578E-2
 2 126
37 1474302 Fluid shear stress and atherosclerosis BioSystems: KEGG 1.263E-3 1.912E-3 8.815E-3
7.073E-2
 2 142
38 1269204 Toll-Like Receptors Cascades BioSystems: REACTOME 1.464E-3 2.158E-3 9.952E-3
8.201E-2
 2 153
39 1268838 Organelle biogenesis and maintenance BioSystems: REACTOME 7.081E-3 1.017E-2 4.689E-2
3.966E-1
 2 341
40 M5290 Role of MEF2D in T-cell Apoptosis MSigDB C2 BIOCARTA (v6.0) 8.407E-3 1.177E-2
5.427E-2
4.708E-1
 1 21
41 1269460 NGF signalling via TRKA from the plasma membrane BioSystems: REACTOME 9.192E-3 1.256E-2
5.790E-2
5.148E-1
 2 390
42 138044 Trk receptor signaling mediated by the MAPK pathway BioSystems: Pathway Interaction Database 1.159E-2 1.546E-2
7.129E-2
6.493E-1
 1 29
43 138062 Signaling events mediated by HDAC Class II BioSystems: Pathway Interaction Database 1.358E-2 1.740E-2
8.023E-2
7.606E-1
 1 34
44 1269443 Signalling by NGF BioSystems: REACTOME 1.389E-2 1.740E-2
8.023E-2
7.780E-1
 2 483
45 M2499 CARM1 and Regulation of the Estrogen Receptor MSigDB C2 BIOCARTA (v6.0) 1.398E-2 1.740E-2
8.023E-2
7.829E-1
 1 35
46 M17400 ALK in cardiac myocytes MSigDB C2 BIOCARTA (v6.0) 1.477E-2 1.799E-2
8.294E-2
8.273E-1
 1 37
47 137972 Signaling events mediated by HDAC Class III BioSystems: Pathway Interaction Database 1.557E-2 1.855E-2
8.553E-2
8.718E-1
 1 39
48 137953 Role of Calcineurin-dependent NFAT signaling in lymphocytes BioSystems: Pathway Interaction Database 2.032E-2 2.370E-2
1.093E-1
1.000E0
 1 51
49 M2288 NFAT and Hypertrophy of the heart (Transcription in the broken heart) MSigDB C2 BIOCARTA (v6.0) 2.150E-2 2.457E-2
1.133E-1
1.000E0
 1 54
50 137916 Regulation of retinoblastoma protein BioSystems: Pathway Interaction Database 2.229E-2 2.497E-2
1.151E-1
1.000E0
 1 56
Show 45 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 1080 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 21531906 Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory. Pubmed 1.692E-16 3.655E-14 2.764E-13 1.828E-13 4 4
2 7643214 Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation. Pubmed 1.692E-16 3.655E-14 2.764E-13 1.828E-13 4 4
3 22764880 Neurotoxin-induced selective ubiquitination and regulation of MEF2A isoform in neuronal stress response. Pubmed 1.692E-16 3.655E-14 2.764E-13 1.828E-13 4 4
4 25416778 MEF2 transcription factors regulate distinct gene programs in mammalian skeletal muscle differentiation. Pubmed 1.692E-16 3.655E-14 2.764E-13 1.828E-13 4 4
5 10207130 Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene. Pubmed 1.692E-16 3.655E-14 2.764E-13 1.828E-13 4 4
6 7646512 The MEF2B homologue differentially expressed in mouse embryonal carcinoma cells. Pubmed 8.460E-16 7.614E-14 5.758E-13 9.137E-13 4 5
7 12694204 Calcineurin initiates skeletal muscle differentiation by activating MEF2 and MyoD. Pubmed 8.460E-16 7.614E-14 5.758E-13 9.137E-13 4 5
8 19093215 Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis. Pubmed 8.460E-16 7.614E-14 5.758E-13 9.137E-13 4 5
9 7760790 Regulatory role of MEF2D in serum induction of the c-jun promoter. Pubmed 8.460E-16 7.614E-14 5.758E-13 9.137E-13 4 5
10 8993831 Absence of MEF2 binding to the A/T-rich element in the muscle creatine kinase (MCK) enhancer correlates with lack of early expression of the MCK gene in embryonic mammalian muscle. Pubmed 8.460E-16 7.614E-14 5.758E-13 9.137E-13 4 5
11 8575763 Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23. Pubmed 8.460E-16 7.614E-14 5.758E-13 9.137E-13 4 5
12 10458488 Expression of MEF2 genes during human cardiac development. Pubmed 8.460E-16 7.614E-14 5.758E-13 9.137E-13 4 5
13 9013788 The expression of MEF2 genes is implicated in CNS neuronal differentiation. Pubmed 2.538E-15 2.108E-13 1.595E-12 2.741E-12 4 6
14 9162005 Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Pubmed 3.553E-14 2.741E-12 2.073E-11 3.837E-11 4 10
15 12130539 Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Pubmed 1.693E-13 1.219E-11 9.219E-11 1.829E-10 4 14
16 17336904 MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Pubmed 4.025E-13 2.717E-11 2.055E-10 4.347E-10 4 17
17 18093911 An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Pubmed 2.154E-12 1.108E-10 8.378E-10 2.326E-9 3 3
18 22496871 In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. Pubmed 2.154E-12 1.108E-10 8.378E-10 2.326E-9 3 3
19 27989458 Experience-Dependent and Differential Regulation of Local and Long-Range Excitatory Neocortical Circuits by Postsynaptic Mef2c. Pubmed 2.154E-12 1.108E-10 8.378E-10 2.326E-9 3 3
20 26286136 Inducible knockout of Mef2a, -c, and -d from nestin-expressing stem/progenitor cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo. Pubmed 2.154E-12 1.108E-10 8.378E-10 2.326E-9 3 3
21 15834131 Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain. Pubmed 2.154E-12 1.108E-10 8.378E-10 2.326E-9 3 3
22 21768366 Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development. Pubmed 2.527E-12 1.241E-10 9.383E-10 2.730E-9 4 26
23 20111592 RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors. Pubmed 4.632E-12 2.085E-10 1.576E-9 5.003E-9 4 30
24 25757744 Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells. Pubmed 4.632E-12 2.085E-10 1.576E-9 5.003E-9 4 30
25 17420000 The transcription factor MEF2C is required for craniofacial development. Pubmed 8.616E-12 3.323E-10 2.513E-9 9.305E-9 3 4
26 23511190 Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity. Pubmed 8.616E-12 3.323E-10 2.513E-9 9.305E-9 3 4
27 8817457 Early expression of the different isoforms of the myocyte enhancer factor-2 (MEF2) protein in myogenic as well as non-myogenic cell lineages during mouse embryogenesis. Pubmed 8.616E-12 3.323E-10 2.513E-9 9.305E-9 3 4
28 24591619 Requirement of MEF2A, C, and D for skeletal muscle regeneration. Pubmed 8.616E-12 3.323E-10 2.513E-9 9.305E-9 3 4
29 20833138 Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Pubmed 2.154E-11 6.646E-10 5.026E-9 2.326E-8 3 5
30 16504037 Cooperation between MEF2 and PPARgamma in human intestinal beta,beta-carotene 15,15'-monooxygenase gene expression. Pubmed 2.154E-11 6.646E-10 5.026E-9 2.326E-8 3 5
31 8900141 Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. Pubmed 2.154E-11 6.646E-10 5.026E-9 2.326E-8 3 5
32 15084602 Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation. Pubmed 2.154E-11 6.646E-10 5.026E-9 2.326E-8 3 5
33 9753748 Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1. Pubmed 2.154E-11 6.646E-10 5.026E-9 2.326E-8 3 5
34 17696759 Control of the SOST bone enhancer by PTH using MEF2 transcription factors. Pubmed 2.154E-11 6.646E-10 5.026E-9 2.326E-8 3 5
35 9858528 Regulation of the MEF2 family of transcription factors by p38. Pubmed 2.154E-11 6.646E-10 5.026E-9 2.326E-8 3 5
36 10737771 Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases. Pubmed 4.307E-11 1.257E-9 9.508E-9 4.652E-8 3 6
37 20399744 TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. Pubmed 4.307E-11 1.257E-9 9.508E-9 4.652E-8 3 6
38 8026334 Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Pubmed 7.538E-11 2.087E-9 1.579E-8 8.141E-8 3 7
39 12861002 Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions. Pubmed 7.538E-11 2.087E-9 1.579E-8 8.141E-8 3 7
40 17786239 Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. Pubmed 1.206E-10 3.177E-9 2.402E-8 1.302E-7 3 8
41 16043483 MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters. Pubmed 1.206E-10 3.177E-9 2.402E-8 1.302E-7 3 8
42 9738004 Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. Pubmed 1.809E-10 4.651E-9 3.517E-8 1.954E-7 3 9
43 28641113 Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. Pubmed 3.553E-10 8.923E-9 6.748E-8 3.837E-7 3 11
44 16424906 Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1. Pubmed 4.736E-10 1.163E-8 8.792E-8 5.115E-7 3 12
45 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 5.880E-10 1.411E-8 1.067E-7 6.350E-7 5 383
46 21447557 Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway. Pubmed 6.157E-10 1.446E-8 1.093E-7 6.650E-7 3 13
47 8114702 A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing. Pubmed 7.836E-10 1.763E-8 1.333E-7 8.463E-7 3 14
48 19782130 Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development. Pubmed 7.836E-10 1.763E-8 1.333E-7 8.463E-7 3 14
49 27779093 MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. Pubmed 1.205E-9 2.657E-8 2.009E-7 1.302E-6 3 16
50 17875930 Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Pubmed 2.862E-9 6.182E-8 4.675E-7 3.091E-6 3 21
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 123 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MEF2B MEF2B interactions 1.209E-12 1.487E-10 8.022E-10 1.487E-10 4 11
2 int:MEF2D MEF2D interactions 3.701E-10 1.849E-8 9.971E-8 4.552E-8 4 41
3 int:MEF2C MEF2C interactions 4.509E-10 1.849E-8 9.971E-8 5.546E-8 4 43
4 int:MEF2A MEF2A interactions 1.904E-9 5.854E-8 3.157E-7 2.341E-7 4 61
5 int:ASCL1 ASCL1 interactions 1.209E-8 2.975E-7 1.605E-6 1.488E-6 3 16
6 int:TEAD1 TEAD1 interactions 7.064E-8 1.448E-6 7.811E-6 8.689E-6 3 28
7 int:CABIN1 CABIN1 interactions 1.817E-7 3.192E-6 1.722E-5 2.235E-5 3 38
8 int:HDAC9 HDAC9 interactions 8.943E-7 1.281E-5 6.910E-5 1.100E-4 3 64
9 int:MAPK7 MAPK7 interactions 9.375E-7 1.281E-5 6.910E-5 1.153E-4 3 65
10 int:VGLL4 VGLL4 interactions 1.814E-5 2.231E-4 1.203E-3 2.231E-3 2 20
11 int:MAPK14 MAPK14 interactions 6.933E-5 7.753E-4 4.181E-3 8.528E-3 3 272
12 int:MYOG MYOG interactions 1.028E-4 1.054E-3 5.682E-3 1.264E-2 2 47
13 int:HDAC4 HDAC4 interactions 1.516E-4 1.366E-3 7.367E-3 1.865E-2 3 354
14 int:HDAC5 HDAC5 interactions 1.555E-4 1.366E-3 7.367E-3 1.912E-2 3 357
15 int:HIST2H3A HIST2H3A interactions 2.223E-4 1.823E-3 9.833E-3 2.735E-2 2 69
16 int:CASP7 CASP7 interactions 2.915E-4 2.241E-3 1.209E-2 3.586E-2 2 79
17 int:HIRA HIRA interactions 3.218E-4 2.328E-3 1.256E-2 3.958E-2 2 83
18 int:DNMT3L DNMT3L interactions 3.455E-4 2.361E-3 1.273E-2 4.250E-2 2 86
19 int:NCOA2 NCOA2 interactions 4.040E-4 2.615E-3 1.410E-2 4.969E-2 2 93
20 int:MYOD1 MYOD1 interactions 4.394E-4 2.627E-3 1.417E-2
5.404E-2
 2 97
21 int:HDAC7 HDAC7 interactions 4.485E-4 2.627E-3 1.417E-2
5.516E-2
 2 98
22 int:CARM1 CARM1 interactions 7.994E-4 4.470E-3 2.411E-2
9.833E-2
 2 131
23 int:MECP2 MECP2 interactions 1.204E-3 6.411E-3 3.458E-2
1.481E-1
 2 161
24 int:BORCS8-MEF2B BORCS8-MEF2B interactions 1.355E-3 6.411E-3 3.458E-2
1.667E-1
 1 4
25 int:XYLT1 XYLT1 interactions 1.355E-3 6.411E-3 3.458E-2
1.667E-1
 1 4
26 int:DLX6 DLX6 interactions 1.355E-3 6.411E-3 3.458E-2
1.667E-1
 1 4
27 int:PHB2 PHB2 interactions 1.436E-3 6.523E-3 3.518E-2
1.766E-1
 2 176
28 int:SKP2 SKP2 interactions 1.485E-3 6.523E-3 3.518E-2
1.826E-1
 2 179
29 int:VGLL2 VGLL2 interactions 1.694E-3 7.184E-3 3.874E-2
2.083E-1
 1 5
30 int:ZCWPW1 ZCWPW1 interactions 2.032E-3 8.063E-3 4.349E-2
2.500E-1
 1 6
31 int:CCDC15 CCDC15 interactions 2.032E-3 8.063E-3 4.349E-2
2.500E-1
 1 6
32 int:SOX18 SOX18 interactions 2.370E-3 9.111E-3 4.914E-2
2.916E-1
 1 7
33 int:TTLL7 TTLL7 interactions 2.709E-3 9.978E-3
5.382E-2
3.332E-1
 1 8
34 int:HDAC3 HDAC3 interactions 2.758E-3 9.978E-3
5.382E-2
3.393E-1
 2 245
35 int:SP1 SP1 interactions 3.147E-3 1.106E-2
5.965E-2
3.871E-1
 2 262
36 int:TWIST2 TWIST2 interactions 3.385E-3 1.157E-2
6.238E-2
4.163E-1
 1 10
37 int:SP7 SP7 interactions 3.723E-3 1.238E-2
6.675E-2
4.579E-1
 1 11
38 int:JUN JUN interactions 3.998E-3 1.294E-2
6.979E-2
4.917E-1
 2 296
39 int:SMAD2 SMAD2 interactions 4.267E-3 1.346E-2
7.258E-2
5.248E-1
 2 306
40 int:PLA2G12A PLA2G12A interactions 4.399E-3 1.353E-2
7.295E-2
5.410E-1
 1 13
41 int:UBN2 UBN2 interactions 5.411E-3 1.585E-2
8.547E-2
6.656E-1
 1 16
42 int:HOXC8 HOXC8 interactions 5.411E-3 1.585E-2
8.547E-2
6.656E-1
 1 16
43 int:DLX2 DLX2 interactions 6.086E-3 1.701E-2
9.176E-2
7.486E-1
 1 18
44 int:IFRD1 IFRD1 interactions 6.086E-3 1.701E-2
9.176E-2
7.486E-1
 1 18
45 int:SH2B1 SH2B1 interactions 6.760E-3 1.732E-2
9.343E-2
8.315E-1
 1 20
46 int:HNF4G HNF4G interactions 6.760E-3 1.732E-2
9.343E-2
8.315E-1
 1 20
47 int:HOXB13 HOXB13 interactions 6.760E-3 1.732E-2
9.343E-2
8.315E-1
 1 20
48 int:HAND1 HAND1 interactions 6.760E-3 1.732E-2
9.343E-2
8.315E-1
 1 20
49 int:SOX8 SOX8 interactions 7.771E-3 1.912E-2
1.031E-1
9.558E-1
 1 23
50 int:TSR3 TSR3 interactions 7.771E-3 1.912E-2
1.031E-1
9.558E-1
 1 23
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7q22 7q22 1.845E-5 9.226E-5 2.107E-4 9.226E-5 2 39
2 1q12-q23 1q12-q23 3.462E-4 8.655E-4 1.976E-3 1.731E-3 1 2
3 5q14 5q14 1.730E-3 2.883E-3 6.583E-3 8.650E-3 1 10
4 15q26 15q26 2.767E-3 3.458E-3 7.897E-3 1.383E-2 1 16
5 19p13.11 19p13.11 1.326E-2 1.326E-2 3.027E-2
6.628E-2
 1 77

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 95 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 6 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 649 Myocyte enhancer factor 2 proteins|MADS box family genenames.org 3.286E-15 9.859E-15 1.808E-14 9.859E-15 4 4
2 1086 Myocyte enhancer factor 2 proteins|MADS box family genenames.org 1.643E-14 2.465E-14 4.519E-14 4.929E-14 4 5
3 519 NKL subclass homeoboxes and pseudogenes genenames.org 1.985E-4 1.985E-4 3.639E-4 5.955E-4 2 67

13: Coexpression [Display Chart] 6 input genes in category / 686 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20013794-Table3 Human CardiacCells Haag09 64genes GeneSigDB 6.982E-10 4.789E-7 3.405E-6 4.789E-7 4 62
2 19658189-TableS8a Human EmbryonicStemCell Xu09 36genes GeneSigDB 6.896E-8 2.365E-5 1.682E-4 4.731E-5 3 36
3 M2492 Examples of transcription factors whose activities are regulated by MAPK11 [GeneID=5600] phosphorylation. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.602E-7 1.281E-4 9.107E-4 3.843E-4 2 5
4 M11218 Examples of transcription factors whose activities are regulated by MAPK7 [GeneID=5598] phosphorylation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.568E-6 2.689E-4 1.912E-3 1.076E-3 2 8
5 18689800-TableS6 Human EmbryonicStemCell Thomas08 113genes GeneSigDB 2.127E-6 2.881E-4 2.048E-3 1.459E-3 3 111
6 M14718 Examples of transcription factors whose activities are regulated by MAPK14 [GeneID=1432] phosphorylation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.520E-6 2.881E-4 2.048E-3 1.728E-3 2 10
7 M5909 Genes involved in development of skeletal muscle (myogenesis). MSigDB H: Hallmark Gene Sets (v6.0) 1.248E-5 1.223E-3 8.697E-3 8.564E-3 3 200
8 18842155-Table2 Human Leukemia Tsai08 30genes GeneSigDB 1.816E-5 1.558E-3 1.107E-2 1.246E-2 2 26
9 18221535-Table2 Human Liver Parent08 55genes GeneSigDB 3.717E-5 2.709E-3 1.925E-2 2.550E-2 2 37
10 14767473-SuppTable2 Human Pancreas Nakamura04 346genes GeneSigDB 3.948E-5 2.709E-3 1.925E-2 2.709E-2 3 294
11 M16123 Muscle development genes up-regulated in Rh4 cells (alveolar rhabdomyosarcoma, ARMS) but not in the RD cells (embryonal rhabdomyosarcoma, ERMS) after knockdown of PAX3-FOXO1 [GeneID=5077;2308] fusion by RNAi for 72 hr. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.827E-5 3.903E-3 2.775E-2 4.684E-2 2 50
12 17449903-Table2 Mouse Skin SuryoRahmanto07 50genes GeneSigDB 6.827E-5 3.903E-3 2.775E-2 4.684E-2 2 50
13 16423987-SuppTable3d Human Leukemia Erkeland06 199genes GeneSigDB 1.421E-4 7.498E-3
5.330E-2
9.748E-2
 2 72
14 M5278 Genes within amplicon 7q21-q22 identified in a copy number alterations study of 191 breast tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.584E-4 7.760E-3
5.516E-2
1.086E-1
 2 76
15 19658189-TableS5 Human EmbryonicStemCell Xu09 622genes GeneSigDB 1.725E-4 7.891E-3
5.609E-2
1.184E-1
 3 483
16 M2640 Genes down-regulated in granule cell neuron precursors (GCNPs) after stimulation with Shh for 24h. MSigDB C6: Oncogenic Signatures (v6.0) 8.845E-4 2.412E-2
1.715E-1
6.068E-1
 2 180
17 M3077 Genes down-regulated in comparison of healthy CD4 [GeneID=920] T cells versus healthy CD19 [GeneID=920] B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.047E-3 2.412E-2
1.715E-1
7.184E-1
 2 196
18 M3085 Genes down-regulated in comparison of systemic lupus erythematosus CD4 [GeneID=920] T cells versus systemic lupus erythematosus B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.058E-3 2.412E-2
1.715E-1
7.257E-1
 2 197
19 M9641 Genes down-regulated in CD4 [GeneID=920] T helper cells (4h): Th0 versus TGFB1 and IL6 [GeneID=7040;3569]. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.412E-2
1.715E-1
7.404E-1
 2 199
20 M4049 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.412E-2
1.715E-1
7.404E-1
 2 199
21 M7294 Genes up-regulated in T reg cells (2h): medium versus TNF [GeneID=7124]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.412E-2
1.715E-1
7.478E-1
 2 200
22 M8734 Genes up-regulated in T cells: control versus IL2 [GeneID=3558] stimulation for 17h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.412E-2
1.715E-1
7.478E-1
 2 200
23 M9292 Genes down-regulated in CD11c+ monocytes: control versus HAdv5 infection. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.412E-2
1.715E-1
7.478E-1
 2 200
24 M9763 Genes down-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: Th1 versus follicular helper (Tfh). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.412E-2
1.715E-1
7.478E-1
 2 200
25 M5966 Genes down-regulated in livers injected with IL6 [GeneID=3569]: SOCS3 [GeneID=9021] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.412E-2
1.715E-1
7.478E-1
 2 200
26 M8836 Genes up-regulated in hematopoietic stem cells versus multipotent progenitors. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.412E-2
1.715E-1
7.478E-1
 2 200
27 M6664 Genes up-regulated in bone marrow-derived macrophagesat 180 min stimulation by LPS: IL6 [GeneID=3469] knockout versus IL10 [GeneID=3486] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.412E-2
1.715E-1
7.478E-1
 2 200
28 M3965 Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.412E-2
1.715E-1
7.478E-1
 2 200
29 M7275 Genes up-regulated in double positve thymocyte: TCF3 [GeneID=6929] knockout versus TCF3 and TCF12 [GeneID=6929;6938] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.412E-2
1.715E-1
7.478E-1
 2 200
30 M9357 Genes down-regulated in day 7 memory B cells versus day 40 memory B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.412E-2
1.715E-1
7.478E-1
 2 200
31 M4545 Genes up-regulated in comparison of thymic progenitors versus DN2 thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.412E-2
1.715E-1
7.478E-1
 2 200
32 M78 Genes up-regulated in Rh4 cells (alveolar rhabdomyosarcoma, ARMS) after knockdown of the PAX3-FOXO1 [GeneiD=5077;2308] fusion protein by RNAi for 72 hr. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.167E-3 2.502E-2
1.778E-1
8.005E-1
 2 207
33 M10117 Genes down-regulated in acute myeloid leukemia (AML) patients with mutated NPM1 [GeneID=4869]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.642E-3 3.413E-2
2.426E-1
1.000E0
 2 246
34 16397240-SuppTable3 Human Colon Grade06 351genes GeneSigDB 1.902E-3 3.837E-2
2.728E-1
1.000E0
 2 265
35 M2378 Genes down-regulated in hypertrophic hearts (due to expression of constitutively active form of PPP3CA [GeneID=5530]) and predicted to be targets of miR-133 microRNA. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.073E-3 4.063E-2
2.888E-1
1.000E0
 1 8
36 M939 Genes up-regulated in hematopoietic progenitor cells (HPC) of B lymphocyte lineage CD34+CD45RA+CD10+ [GeneID=947;5788;4311]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.318E-3 4.417E-2
3.140E-1
1.000E0
 2 293
37 M17374 Genes up-regulated in DLD1 cells (colon cancer) by p73 beta [GeneID=7161] or by and p63 gamma [GeneID=8626] but not by p53 [GeneID=7157]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.849E-3 4.904E-2
3.487E-1
1.000E0
 1 11
38 M10382 Genes down-regulated in hepatocellular carcinoma (HCC) tumors with higher risk of early intrahepatic recurrence. The single up-regulated gene (GenBank Accession=AC000063) has been excluded from the signature. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.849E-3 4.904E-2
3.487E-1
1.000E0
 1 11
39 12456497-Table3 Human Leukemia Durig03 14genes GeneSigDB 2.849E-3 4.904E-2
3.487E-1
1.000E0
 1 11
40 M13206 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1 [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.860E-3 4.904E-2
3.487E-1
1.000E0
 2 326
Show 35 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 924 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup5 Inhibitory.subGroup5 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup5 Inhibitory.subGroup5 Overall Top 200 Genes BrainMap 1.234E-5 5.976E-3 4.426E-2 1.140E-2 3 188
2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup5 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup5 BrainMap 1.294E-5 5.976E-3 4.426E-2 1.195E-2 3 191
3 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup5 Inhibitory.subGroup5 Subtype Inhibitory.subGroup5 PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup5 Inhibitory.subGroup5 Subtype Inhibitory.subGroup5 PosteriorCortex Top 200 Genes BrainMap 2.859E-5 6.737E-3 4.990E-2 2.642E-2 3 249
4 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2 BrainMap 3.950E-5 6.737E-3 4.990E-2 3.650E-2 2 36
5 Facebase RNAseq e10.5 Mandibular Arch 500 K2 FacebaseRNAseq e10.5 Mandibular Arch top-relative-expression-ranked 500 k-means-cluster#2 FaceBase_RNAseq 4.888E-5 6.737E-3 4.990E-2 4.517E-2 2 40
6 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup5 Inhibitory.subGroup5 Subtype Inhibitory.subGroup5 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup5 Inhibitory.subGroup5 Subtype Inhibitory.subGroup5 FrontalCortex Top 200 Genes BrainMap 6.211E-5 6.737E-3 4.990E-2
5.739E-2
 3 323
7 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Gad1,Gad2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Gad1,Gad2 Top 200 Genes BrainMap 6.211E-5 6.737E-3 4.990E-2
5.739E-2
 3 323
8 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup5 Inhibitory.subGroup5 Subtype Inhibitory.subGroup5 Hippocampus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup5 Inhibitory.subGroup5 Subtype Inhibitory.subGroup5 Hippocampus Top 200 Genes BrainMap 6.326E-5 6.737E-3 4.990E-2
5.845E-2
 3 325
9 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Pvalb,Nefm Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Pvalb,Nefm Top 200 Genes BrainMap 6.923E-5 6.737E-3 4.990E-2
6.397E-2
 3 335
10 Facebase RNAseq ratio e10.5 MandibularArch vs MaxillaryArch 500 K1 FacebaseRNAseq ratio e10.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 500 k-means-cluster#1 FaceBase_RNAseq 7.362E-5 6.737E-3 4.990E-2
6.802E-2
 2 49
11 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup5 Inhibitory.subGroup5 Subtype Inhibitory.subGroup5 Striatum Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup5 Inhibitory.subGroup5 Subtype Inhibitory.subGroup5 Striatum Top 200 Genes BrainMap 8.020E-5 6.737E-3 4.990E-2
7.411E-2
 3 352
12 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory BrainMap 1.144E-4 8.808E-3
6.524E-2
1.057E-1
 2 61
13 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Top 200 BrainMap 1.962E-4 1.395E-2
1.033E-1
1.813E-1
 3 476
14 Facebase RNAseq e9.5 Maxillary Arch 100 FacebaseRNAseq e9.5 Maxillary Arch top-relative-expression-ranked 100 FaceBase_RNAseq 2.898E-4 1.465E-2
1.085E-1
2.677E-1
 2 97
15 Facebase RNAseq e9.5 Olfactory Placode 100 FacebaseRNAseq e9.5 Olfactory Placode top-relative-expression-ranked 100 FaceBase_RNAseq 2.958E-4 1.465E-2
1.085E-1
2.733E-1
 2 98
16 Facebase RNAseq e9.5 Mandibular Arch 100 FacebaseRNAseq e9.5 Mandibular Arch top-relative-expression-ranked 100 FaceBase_RNAseq 2.958E-4 1.465E-2
1.085E-1
2.733E-1
 2 98
17 Facebase RNAseq e10.5 Neural Epithelium Overlying Medial Eminence 100 FacebaseRNAseq e10.5 Neural Epithelium Overlying Medial Eminence top-relative-expression-ranked 100 FaceBase_RNAseq 3.018E-4 1.465E-2
1.085E-1
2.789E-1
 2 99
18 Facebase RNAseq e10.5 Mandibular Arch 100 FacebaseRNAseq e10.5 Mandibular Arch top-relative-expression-ranked 100 FaceBase_RNAseq 3.079E-4 1.465E-2
1.085E-1
2.845E-1
 2 100
19 Facebase RNAseq e10.5 Olfactory Pit 100 FacebaseRNAseq e10.5 Olfactory Pit top-relative-expression-ranked 100 FaceBase_RNAseq 3.079E-4 1.465E-2
1.085E-1
2.845E-1
 2 100
20 Facebase RNAseq e10.5 Mandibular Arch 1000 K1 FacebaseRNAseq e10.5 Mandibular Arch top-relative-expression-ranked 1000 k-means-cluster#1 FaceBase_RNAseq 3.267E-4 1.465E-2
1.085E-1
3.018E-1
 2 103
21 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type B3/4/4 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type B3/4/4 TCGA-Thymus 3.330E-4 1.465E-2
1.085E-1
3.077E-1
 2 104
22 Facebase RNAseq e9.5 Mandibular Arch 500 K3 FacebaseRNAseq e9.5 Mandibular Arch top-relative-expression-ranked 500 k-means-cluster#3 FaceBase_RNAseq 3.793E-4 1.497E-2
1.109E-1
3.505E-1
 2 111
23 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Tumour PapRCC Renal cell carcinoma/Kidney Tumour PapRCC T4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Tumour PapRCC Renal cell carcinoma/Kidney Tumour PapRCC T4 Adult, Development, and Cancer types 4.000E-4 1.497E-2
1.109E-1
3.696E-1
 2 114
24 Facebase RNAseq e8.5 Paraxial Mesoderm 1000 K5 FacebaseRNAseq e8.5 Paraxial Mesoderm top-relative-expression-ranked 1000 k-means-cluster#5 FaceBase_RNAseq 4.000E-4 1.497E-2
1.109E-1
3.696E-1
 2 114
25 endometrium endometrium Human Protein Atlas 4.070E-4 1.497E-2
1.109E-1
3.761E-1
 2 115
26 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Microglia/Microglia/Microglia/C1qb//Tmem119/Microglia.C1qb.Tmem119/Striatum BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Microglia/Microglia/Microglia/C1qb//Tmem119/Microglia.C1qb.Tmem119/Striatum BrainMap 4.213E-4 1.497E-2
1.109E-1
3.893E-1
 2 117
27 Facebase RNAseq e9.5 Maxillary Arch 500 K4 FacebaseRNAseq e9.5 Maxillary Arch top-relative-expression-ranked 500 k-means-cluster#4 FaceBase_RNAseq 5.521E-4 1.846E-2
1.368E-1
5.101E-1
 2 134
28 gudmap developingGonad e18.5 epididymis 1000 k2 DevelopingGonad e18.5 epididymis emap-13166 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.938E-4 1.846E-2
1.368E-1
5.487E-1
 2 139
29 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Car4/Endothelial Stalk.Flt1.Car4/Striatum BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Car4/Endothelial Stalk.Flt1.Car4/Striatum BrainMap 6.109E-4 1.846E-2
1.368E-1
5.645E-1
 2 141
30 gudmap developingGonad P2 epididymis 1000 k5 DevelopingGonad P2 epididymis emap-30199 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.109E-4 1.846E-2
1.368E-1
5.645E-1
 2 141
31 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup4/Asb4 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup4/Asb4 BrainMap 7.002E-4 1.846E-2
1.368E-1
6.469E-1
 2 151
32 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Esophagus Squamous Cell Carcinoma/6/1 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Esophagus Squamous Cell Carcinoma/6/1 TCGA-Esophagus 7.094E-4 1.846E-2
1.368E-1
6.555E-1
 2 152
33 Facebase ST1 e10.5 MandibArch 250 e10.5 MandibArch top-relative-expression-ranked 250 FaceBase_ST1 7.855E-4 1.846E-2
1.368E-1
7.258E-1
 2 160
34 BrainMap BrainAtlas - Mouse McCarroll Striatum Striatum Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Striatum Striatum Overall Top 200 Genes BrainMap 8.451E-4 1.846E-2
1.368E-1
7.809E-1
 2 166
35 Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma/4/1 Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma/4/1 TCGA-Uterus 8.451E-4 1.846E-2
1.368E-1
7.809E-1
 2 166
36 Sample Type by Project: Shred 1/TCGA-Cervix/Cervical Carcinoma/Non-keratinizing Cervical Squamous Cell Carcinoma/1/1 Sample Type by Project: Shred 1/TCGA-Cervix/Cervical Carcinoma/Non-keratinizing Cervical Squamous Cell Carcinoma/1/1 TCGA-Cervix 8.757E-4 1.846E-2
1.368E-1
8.092E-1
 2 169
37 Sample Type by Project: Shred 1/TCGA-Cervix/Endocervical Adenocarcinoma/Endometrioid Adenocarcinoma/1 Sample Type by Project: Shred 1/TCGA-Cervix/Endocervical Adenocarcinoma/Endometrioid Adenocarcinoma/1 TCGA-Cervix 9.385E-4 1.846E-2
1.368E-1
8.672E-1
 2 175
38 BrainMap BrainAtlas - Mouse McCarroll GlobusPallidus GlobusPallidus Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll GlobusPallidus GlobusPallidus Overall Top 200 Genes BrainMap 9.385E-4 1.846E-2
1.368E-1
8.672E-1
 2 175
39 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2-like/Kidney NephrogenicRest Wilms MNP2-like Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2-like/Kidney NephrogenicRest Wilms MNP2-like Adult, Development, and Cancer types 9.599E-4 1.846E-2
1.368E-1
8.870E-1
 2 177
40 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Overall Top 200 Genes BrainMap 1.003E-3 1.846E-2
1.368E-1
9.272E-1
 2 181
41 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour RCC U U/Kidney Tumour RCC U8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour RCC U U/Kidney Tumour RCC U8 Adult, Development, and Cancer types 1.037E-3 1.846E-2
1.368E-1
9.579E-1
 2 184
42 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Tumour RCC Nephron epithelium/Kidney Tumour RCC N8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Tumour RCC Nephron epithelium/Kidney Tumour RCC N8 Adult, Development, and Cancer types 1.037E-3 1.846E-2
1.368E-1
9.579E-1
 2 184
43 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Tumour RCC EN-A/Kidney Tumour RCC EN8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Tumour RCC EN-A/Kidney Tumour RCC EN8 Adult, Development, and Cancer types 1.037E-3 1.846E-2
1.368E-1
9.579E-1
 2 184
44 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour RCC PT-U/Kidney Tumour RCC PT8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour RCC PT-U/Kidney Tumour RCC PT8 Adult, Development, and Cancer types 1.037E-3 1.846E-2
1.368E-1
9.579E-1
 2 184
45 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour RCC R U/Kidney Tumour RCC R8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour RCC R U/Kidney Tumour RCC R8 Adult, Development, and Cancer types 1.037E-3 1.846E-2
1.368E-1
9.579E-1
 2 184
46 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Tumour RCC IF-U/Kidney Tumour RCC IF8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Tumour RCC IF-U/Kidney Tumour RCC IF8 Adult, Development, and Cancer types 1.048E-3 1.846E-2
1.368E-1
9.682E-1
 2 185
47 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Tumour RCC Nephrogenesis/Kidney Tumour RCC F8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Tumour RCC Nephrogenesis/Kidney Tumour RCC F8 Adult, Development, and Cancer types 1.048E-3 1.846E-2
1.368E-1
9.682E-1
 2 185
48 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup2 Inhibitory.subGroup2 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup2 Inhibitory.subGroup2 Overall Top 200 Genes BrainMap 1.048E-3 1.846E-2
1.368E-1
9.682E-1
 2 185
49 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Gad1,Gad2 Neuron.mixed excitatory.Gad1,Gad2 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Gad1,Gad2 Neuron.mixed excitatory.Gad1,Gad2 Overall Top 200 Genes BrainMap 1.048E-3 1.846E-2
1.368E-1
9.682E-1
 2 185
50 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Gad1,Gad2 Neuron.mixed excitatory.Gad1,Gad2 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Gad1,Gad2 Neuron.mixed excitatory.Gad1,Gad2 Top 200 BrainMap 1.048E-3 1.846E-2
1.368E-1
9.682E-1
 2 185
Show 45 more annotations

15: Computational [Display Chart] 4 input genes in category / 25 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13751 MODULE 123 Genes in the cancer module 123. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.783E-5 1.446E-3 5.517E-3 1.446E-3 3 247
2 M1846 MODULE 220 Developmental processes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.412E-4 1.765E-3 6.737E-3 3.531E-3 3 333
3 M6320 MODULE 257 Genes in the cancer module 257. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.411E-3 1.095E-2 4.179E-2 3.527E-2 2 156
4 M4092 MODULE 197 Genes in the cancer module 197. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.752E-3 1.095E-2 4.179E-2 4.381E-2 2 174

16: MicroRNA [Display Chart] 6 input genes in category / 476 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-421:PITA hsa-miR-421:PITA TOP PITA 2.328E-6 1.108E-3 7.472E-3 1.108E-3 3 355
2 hsa-miR-609:PITA hsa-miR-609:PITA TOP PITA 1.156E-5 2.752E-3 1.856E-2 5.504E-3 2 64
3 hsa-miR-645:PITA hsa-miR-645:PITA TOP PITA 2.046E-5 3.049E-3 2.056E-2 9.739E-3 2 85
4 hsa-miR-1254:PITA hsa-miR-1254:PITA TOP PITA 4.946E-5 3.049E-3 2.056E-2 2.354E-2 2 132
5 hsa-miR-1302:PITA hsa-miR-1302:PITA TOP PITA 6.475E-5 3.049E-3 2.056E-2 3.082E-2 2 151
6 hsa-miR-190:PITA hsa-miR-190:PITA TOP PITA 7.000E-5 3.049E-3 2.056E-2 3.332E-2 2 157
7 hsa-miR-190b:PITA hsa-miR-190b:PITA TOP PITA 7.000E-5 3.049E-3 2.056E-2 3.332E-2 2 157
8 CATGTAA,MIR-496:MSigDB CATGTAA,MIR-496:MSigDB MSigDB 7.638E-5 3.049E-3 2.056E-2 3.636E-2 2 164
9 hsa-miR-342-3p:PITA hsa-miR-342-3p:PITA TOP PITA 7.920E-5 3.049E-3 2.056E-2 3.770E-2 2 167
10 hsa-miR-190b:TargetScan hsa-miR-190b TargetScan 7.920E-5 3.049E-3 2.056E-2 3.770E-2 2 167
11 hsa-miR-190a-5p:TargetScan hsa-miR-190a-5p TargetScan 7.920E-5 3.049E-3 2.056E-2 3.770E-2 2 167
12 hsa-miR-219-5p:PITA hsa-miR-219-5p:PITA TOP PITA 8.401E-5 3.049E-3 2.056E-2 3.999E-2 2 172
13 ACTGAAA,MIR-30E-3P:MSigDB ACTGAAA,MIR-30E-3P:MSigDB MSigDB 1.014E-4 3.049E-3 2.056E-2 4.828E-2 2 189
14 ACTGAAA,MIR-30A-3P:MSigDB ACTGAAA,MIR-30A-3P:MSigDB MSigDB 1.014E-4 3.049E-3 2.056E-2 4.828E-2 2 189
15 hsa-miR-18a:PITA hsa-miR-18a:PITA TOP PITA 1.025E-4 3.049E-3 2.056E-2 4.879E-2 2 190
16 hsa-miR-18b:PITA hsa-miR-18b:PITA TOP PITA 1.025E-4 3.049E-3 2.056E-2 4.879E-2 2 190
17 CTTTGCA,MIR-527:MSigDB CTTTGCA,MIR-527:MSigDB MSigDB 1.337E-4 3.742E-3 2.524E-2
6.362E-2
 2 217
18 hsa-miR-223:PITA hsa-miR-223:PITA TOP PITA 1.514E-4 4.004E-3 2.700E-2
7.208E-2
 2 231
19 hsa-miR-582-3p:PITA hsa-miR-582-3p:PITA TOP PITA 1.888E-4 4.651E-3 3.136E-2
8.986E-2
 2 258
20 CATTTCA,MIR-203:MSigDB CATTTCA,MIR-203:MSigDB MSigDB 1.976E-4 4.651E-3 3.136E-2
9.408E-2
 2 264
21 hsa-miR-298:PITA hsa-miR-298:PITA TOP PITA 2.052E-4 4.651E-3 3.136E-2
9.767E-2
 2 269
22 hsa-miR-223-3p:TargetScan hsa-miR-223-3p TargetScan 2.254E-4 4.858E-3 3.276E-2
1.073E-1
 2 282
23 hsa-miR-509-3-5p:PITA hsa-miR-509-3-5p:PITA TOP PITA 2.449E-4 4.858E-3 3.276E-2
1.166E-1
 2 294
24 hsa-miR-509-5p:PITA hsa-miR-509-5p:PITA TOP PITA 2.449E-4 4.858E-3 3.276E-2
1.166E-1
 2 294
25 TTGCCAA,MIR-182:MSigDB TTGCCAA,MIR-182:MSigDB MSigDB 2.653E-4 4.923E-3 3.320E-2
1.263E-1
 2 306
26 hsa-miR-1259:PITA hsa-miR-1259:PITA TOP PITA 2.757E-4 4.923E-3 3.320E-2
1.312E-1
 2 312
27 TGCTTTG,MIR-330:MSigDB TGCTTTG,MIR-330:MSigDB MSigDB 2.793E-4 4.923E-3 3.320E-2
1.329E-1
 2 314
28 hsa-miR-421:TargetScan hsa-miR-421 TargetScan 3.120E-4 5.305E-3 3.577E-2
1.485E-1
 2 332
29 hsa-miR-665:TargetScan hsa-miR-665 TargetScan 3.585E-4 5.885E-3 3.969E-2
1.707E-1
 2 356
30 hsa-miR-933:mirSVR lowEffct hsa-miR-933:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 4.018E-4 6.266E-3 4.225E-2
1.913E-1
 2 377
31 hsa-miR-603:PITA hsa-miR-603:PITA TOP PITA 4.190E-4 6.266E-3 4.225E-2
1.994E-1
 2 385
32 hsa-miR-103:PITA hsa-miR-103:PITA TOP PITA 4.409E-4 6.266E-3 4.225E-2
2.099E-1
 2 395
33 hsa-miR-107:PITA hsa-miR-107:PITA TOP PITA 4.409E-4 6.266E-3 4.225E-2
2.099E-1
 2 395
34 hsa-miR-380:PITA hsa-miR-380:PITA TOP PITA 4.476E-4 6.266E-3 4.225E-2
2.130E-1
 2 398
35 CTTTGTA,MIR-524:MSigDB CTTTGTA,MIR-524:MSigDB MSigDB 4.725E-4 6.297E-3 4.246E-2
2.249E-1
 2 409
36 hsa-miR-551b-3p:TargetScan hsa-miR-551b-3p TargetScan 4.982E-4 6.297E-3 4.246E-2
2.372E-1
 1 6
37 hsa-miR-551a:TargetScan hsa-miR-551a TargetScan 4.982E-4 6.297E-3 4.246E-2
2.372E-1
 1 6
38 hsa-miR-211:PITA hsa-miR-211:PITA TOP PITA 5.243E-4 6.297E-3 4.246E-2
2.496E-1
 2 431
39 hsa-miR-204:PITA hsa-miR-204:PITA TOP PITA 5.243E-4 6.297E-3 4.246E-2
2.496E-1
 2 431
40 hsa-miR-105:PITA hsa-miR-105:PITA TOP PITA 5.292E-4 6.297E-3 4.246E-2
2.519E-1
 2 433
41 hsa-miR-555:mirSVR highEffct hsa-miR-555:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.737E-4 6.661E-3 4.492E-2
2.731E-1
 2 451
42 hsa-miR-582-5p:TargetScan hsa-miR-582-5p TargetScan 5.890E-4 6.675E-3 4.502E-2
2.804E-1
 2 457
43 hsa-miR-182:PITA hsa-miR-182:PITA TOP PITA 6.466E-4 7.024E-3 4.737E-2
3.078E-1
 2 479
44 hsa-miR-140-3p.1:TargetScan hsa-miR-140-3p.1 TargetScan 6.493E-4 7.024E-3 4.737E-2
3.091E-1
 2 480
45 hsa-miR-615-3p:TargetScan hsa-miR-615-3p TargetScan 9.133E-4 9.661E-3
6.515E-2
4.347E-1
 1 11
46 hsa-miR-147b:TargetScan hsa-miR-147b TargetScan 1.245E-3 1.261E-2
8.505E-2
5.927E-1
 1 15
47 hsa-miR-516a-5p:PITA hsa-miR-516a-5p:PITA TOP PITA 1.245E-3 1.261E-2
8.505E-2
5.927E-1
 1 15
48 hsa-miR-451a:TargetScan hsa-miR-451a TargetScan 1.577E-3 1.564E-2
1.055E-1
7.507E-1
 1 19
49 hsa-miR-611:PITA hsa-miR-611:PITA TOP PITA 1.826E-3 1.774E-2
1.196E-1
8.691E-1
 1 22
50 hsa-miR-5739:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.075E-3 1.975E-2
1.332E-1
9.875E-1
 1 25
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 1626 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000006278 1,1,1-trichloroethane Stitch 3.107E-8 5.052E-5 4.027E-4 5.052E-5 4 156
2 ctd:D008687 Metformin CTD 1.407E-6 8.649E-4 6.894E-3 2.287E-3 4 404
3 ctd:D001374 Azacitidine CTD 1.596E-6 8.649E-4 6.894E-3 2.595E-3 4 417
4 CID000012388 tridecane Stitch 2.726E-6 1.053E-3 8.396E-3 4.433E-3 3 119
5 CID000017513 acadesine Stitch 3.239E-6 1.053E-3 8.396E-3 5.266E-3 3 126
6 CID000002783 clenbuterol Stitch 4.641E-6 1.258E-3 1.003E-2 7.546E-3 3 142
7 CID000000200 AICAR monophosphate Stitch 7.024E-6 1.632E-3 1.301E-2 1.142E-2 3 163
8 CID000003837 AC1L1GTT Stitch 2.049E-5 4.164E-3 3.320E-2 3.332E-2 3 233
9 CID000007050 MDAC Stitch 2.842E-5 5.135E-3 4.093E-2 4.622E-2 2 32
10 CID005281701 tricetin Stitch 3.608E-5 5.867E-3 4.677E-2
5.867E-2
 2 36
11 ctd:D003620 Dantrolene CTD 4.694E-5 6.939E-3
5.531E-2
7.632E-2
 2 41
12 CID000007104 B on A Stitch 1.592E-4 2.157E-2
1.719E-1
2.588E-1
 3 464
13 CID000008588 3-amino-9-ethylcarbazole Stitch 2.382E-4 2.164E-2
1.725E-1
3.873E-1
 2 92
14 CID006439158 AC1O5R3K Stitch 2.928E-4 2.164E-2
1.725E-1
4.760E-1
 2 102
15 CID000008202 methyl 9-octadecenoate Stitch 3.529E-4 2.164E-2
1.725E-1
5.738E-1
 2 112
16 2211 UP Astemizole [68844-77-9]; Up 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.742E-4 2.164E-2
1.725E-1
1.000E0
 2 155
17 ctd:D002185 Cannabidiol CTD 7.360E-4 2.164E-2
1.725E-1
1.000E0
 2 162
18 ctd:C577051 bis(3)-cognitin CTD 7.879E-4 2.164E-2
1.725E-1
1.000E0
 1 3
19 3993 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 8.776E-4 2.164E-2
1.725E-1
1.000E0
 2 177
20 3643 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 9.478E-4 2.164E-2
1.725E-1
1.000E0
 2 184
21 CID003509873 AC1MQZ6I Stitch 1.010E-3 2.164E-2
1.725E-1
1.000E0
 2 190
22 3803 DN Flutamide [13311-84-7]; Down 200; 14.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.021E-3 2.164E-2
1.725E-1
1.000E0
 2 191
23 6390 DN 5707885; Down 200; 50uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.021E-3 2.164E-2
1.725E-1
1.000E0
 2 191
24 5965 UP LY294002; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.042E-3 2.164E-2
1.725E-1
1.000E0
 2 193
25 2872 UP Bromperidol [10457-90-6]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.042E-3 2.164E-2
1.725E-1
1.000E0
 2 193
26 4676 UP Testosterone propionate [57-85-2]; Up 200; 11.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.042E-3 2.164E-2
1.725E-1
1.000E0
 2 193
27 2333 UP Dilazep dihydrochloride [20153-98-4]; Up 200; 6uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.063E-3 2.164E-2
1.725E-1
1.000E0
 2 195
28 3812 DN Diethylstilbestrol [56-53-1]; Down 200; 15uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.063E-3 2.164E-2
1.725E-1
1.000E0
 2 195
29 4738 UP Graveoline [485-61-0]; Up 200; 14.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.063E-3 2.164E-2
1.725E-1
1.000E0
 2 195
30 2663 DN haloperidol; Down 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.063E-3 2.164E-2
1.725E-1
1.000E0
 2 195
31 4723 UP Methotrimeprazine maleat salt [7104-38-3]; Up 200; 9uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.063E-3 2.164E-2
1.725E-1
1.000E0
 2 195
32 4491 DN Althiazide [5588-16-9]; Down 200; 10.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
33 4733 UP Sulfamethoxypyridazine [80-35-3]; Up 200; 14.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
34 5736 UP Trioxsalen [3902-71-4]; Up 200; 17.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
35 2576 DN Alexidine dihydrochloride [22573-93-9]; Down 200; 6.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
36 3726 UP Aminopurine, 6-benzyl [1214-39-7]; Up 200; 17.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
37 3890 UP Beta-Escin [11072-93-8]; Up 200; 3.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
38 2924 DN Oxamniquine [21738-42-1]; Down 200; 14.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
39 3706 UP Demeclocycline hydrochloride [64-73-3]; Up 200; 8uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
40 1312 DN Thyroxine (L) [51-48-9]; Down 200; 5.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
41 2736 DN Trimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
42 4218 DN Pregnenolone [145-13-1]; Down 200; 12.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
43 4114 UP Fluvoxamine maleate [61718-82-9]; Up 200; 9.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
44 2063 UP Nalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.074E-3 2.164E-2
1.725E-1
1.000E0
 2 196
45 4150 UP Thyroxine (L) [51-48-9]; Up 200; 5.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.085E-3 2.164E-2
1.725E-1
1.000E0
 2 197
46 3365 UP Ioversol [87771-40-2]; Up 200; 5uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.085E-3 2.164E-2
1.725E-1
1.000E0
 2 197
47 3719 UP Bromopride [4093-35-0]; Up 200; 11.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.085E-3 2.164E-2
1.725E-1
1.000E0
 2 197
48 4418 UP Ethionamide [536-33-4]; Up 200; 24uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.085E-3 2.164E-2
1.725E-1
1.000E0
 2 197
49 5450 UP Dimenhydrinate [523-87-5]; Up 200; 8.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.085E-3 2.164E-2
1.725E-1
1.000E0
 2 197
50 2738 DN Raloxifene hydrochloride [82640-04-8]; Down 200; 7.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.085E-3 2.164E-2
1.725E-1
1.000E0
 2 197
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 132 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1839730 Prieto X-linked mental retardation syndrome DisGeNET Curated 2.397E-6 2.109E-4 1.152E-3 3.164E-4 2 7
2 C1865295 Auriculo-condylar syndrome DisGeNET Curated 3.196E-6 2.109E-4 1.152E-3 4.218E-4 2 8
3 C0016508 Congenital Foot Deformity DisGeNET Curated 1.038E-5 4.565E-4 2.494E-3 1.370E-3 2 14
4 C0740404 limb defects DisGeNET BeFree 6.002E-5 1.981E-3 1.082E-2 7.922E-3 2 33
5 C2931019 Split hand foot deformity 1 DisGeNET BeFree 8.856E-5 2.150E-3 1.175E-2 1.169E-2 2 40
6 C0221373 Claw hand DisGeNET Curated 9.772E-5 2.150E-3 1.175E-2 1.290E-2 2 42
7 C0339527 Leber Congenital Amaurosis DisGeNET Curated 1.621E-4 3.057E-3 1.670E-2 2.140E-2 2 54
8 cv:C1857344 Split-hand/foot malformation 1 with sensorineural hearing loss Clinical Variations 3.703E-4 3.258E-3 1.780E-2 4.887E-2 1 1
9 C3150700 MENTAL RETARDATION, AUTOSOMAL DOMINANT 20 DisGeNET Curated 3.703E-4 3.258E-3 1.780E-2 4.887E-2 1 1
10 OMIN:608320 CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1; ADCAD1 OMIM 3.703E-4 3.258E-3 1.780E-2 4.887E-2 1 1
11 C1275836 D - transposition of the great vessels DisGeNET BeFree 3.703E-4 3.258E-3 1.780E-2 4.887E-2 1 1
12 cv:C3150700 Mental retardation, stereotypic movements, epilepsy, and/or cerebral malformations Clinical Variations 3.703E-4 3.258E-3 1.780E-2 4.887E-2 1 1
13 OMIN:613443 MENTAL RETARDATION, STEREOTYPIC MOVEMENTS, EPILEPSY, AND/OR CEREBRAL MALFORMATIONS OMIM 3.703E-4 3.258E-3 1.780E-2 4.887E-2 1 1
14 C1857344 Split-Hand-Foot Malformation With Sensorineural Hearing Loss DisGeNET Curated 3.703E-4 3.258E-3 1.780E-2 4.887E-2 1 1
15 cv:C1842247 Coronary artery disease, autosomal dominant, 1 Clinical Variations 3.703E-4 3.258E-3 1.780E-2 4.887E-2 1 1
16 C0027868 Neuromuscular Diseases DisGeNET Curated 5.130E-4 3.983E-3 2.176E-2
6.771E-2
 2 96
17 C1837218 Cleft palate, isolated DisGeNET BeFree 5.130E-4 3.983E-3 2.176E-2
6.771E-2
 2 96
18 C1842247 CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1 DisGeNET Curated 7.404E-4 5.430E-3 2.967E-2
9.773E-2
 1 2
19 C0035372 Rett Syndrome DisGeNET Curated 8.955E-4 6.191E-3 3.382E-2
1.182E-1
 2 127
20 C0027126 Myotonic Dystrophy DisGeNET Curated 9.380E-4 6.191E-3 3.382E-2
1.238E-1
 2 130
21 C0041408 Turner Syndrome DisGeNET Curated 1.330E-3 8.357E-3 4.566E-2
1.755E-1
 2 155
22 C0085215 Ovarian Failure, Premature DisGeNET Curated 1.596E-3 9.578E-3
5.233E-2
2.107E-1
 2 170
23 C0376634 Craniofacial Abnormalities DisGeNET Curated 1.847E-3 9.769E-3
5.337E-2
2.438E-1
 2 183
24 C0265886 Overriding aorta DisGeNET Curated 1.850E-3 9.769E-3
5.337E-2
2.442E-1
 1 5
25 C2748910 Rett Syndrome, Atypical DisGeNET Curated 1.850E-3 9.769E-3
5.337E-2
2.442E-1
 1 5
26 C2981150 Uranostaphyloschisis DisGeNET Curated 2.514E-3 1.221E-2
6.670E-2
3.319E-1
 2 214
27 C3887496 Oligodactyly DisGeNET Curated 2.589E-3 1.221E-2
6.670E-2
3.418E-1
 1 7
28 C1856113 Mowat-Wilson syndrome DisGeNET Curated 2.589E-3 1.221E-2
6.670E-2
3.418E-1
 1 7
29 C0008925 Cleft Palate DisGeNET Curated 3.307E-3 1.417E-2
7.743E-2
4.365E-1
 2 246
30 C1839323 Small chin DisGeNET Curated 3.328E-3 1.417E-2
7.743E-2
4.393E-1
 1 9
31 C3697248 Short lower third of face DisGeNET Curated 3.328E-3 1.417E-2
7.743E-2
4.393E-1
 1 9
32 C0454455 Mirror movements disorder DisGeNET Curated 3.697E-3 1.525E-2
8.333E-2
4.881E-1
 1 10
33 C1857276 Trichohepatoenteric Syndrome DisGeNET Curated 3.969E-3 1.579E-2
8.626E-2
5.239E-1
 2 270
34 C1960546 Myxoma of heart DisGeNET Curated 4.067E-3 1.579E-2
8.626E-2
5.368E-1
 1 11
35 C1445953 Poor eye contact DisGeNET Curated 4.436E-3 1.673E-2
9.140E-2
5.855E-1
 1 12
36 C0262929 Myxoma of the Endocardium DisGeNET BeFree 4.804E-3 1.762E-2
9.625E-2
6.342E-1
 1 13
37 C0079772 T-Cell Lymphoma DisGeNET Curated 5.135E-3 1.832E-2
1.001E-1
6.778E-1
 2 308
38 C0432028 Split foot DisGeNET Curated 5.542E-3 1.925E-2
1.052E-1
7.315E-1
 1 15
39 C0035309 Retinal Diseases DisGeNET Curated 5.875E-3 1.973E-2
1.078E-1
7.755E-1
 2 330
40 20081125:Levy Blood pressure GWAS 6.279E-3 1.973E-2
1.078E-1
8.288E-1
 1 17
41 C0013069 Double Outlet Right Ventricle DisGeNET Curated 6.279E-3 1.973E-2
1.078E-1
8.288E-1
 1 17
42 C0031900 Pierre Robin Syndrome DisGeNET Curated 6.279E-3 1.973E-2
1.078E-1
8.288E-1
 1 17
43 C1533172 Infantile nystagmus syndrome DisGeNET BeFree 6.647E-3 2.041E-2
1.115E-1
8.774E-1
 1 18
44 C0035412 Rhabdomyosarcoma DisGeNET Curated 8.168E-3 2.450E-2
1.339E-1
1.000E0
 2 391
45 C0265554 Ectrodactyly DisGeNET Curated 9.222E-3 2.646E-2
1.446E-1
1.000E0
 1 25
46 C0027019 Myelomonocytic leukemia DisGeNET BeFree 9.222E-3 2.646E-2
1.446E-1
1.000E0
 1 25
47 C0027765 nervous system disorder DisGeNET Curated 9.511E-3 2.671E-2
1.459E-1
1.000E0
 2 423
48 C0878544 Cardiomyopathies DisGeNET Curated 9.950E-3 2.716E-2
1.484E-1
1.000E0
 2 433
49 C1510586 Autism Spectrum Disorders DisGeNET Curated 1.008E-2 2.716E-2
1.484E-1
1.000E0
 2 436
50 C2699510 Split-Hand/Foot Malformation DisGeNET BeFree 1.216E-2 3.210E-2
1.754E-1
1.000E0
 1 33
Show 45 more annotations