Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc288_8, positive side

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1: GO: Molecular Function [Display Chart] 8 input genes in category / 50 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003730 mRNA 3'-UTR binding 9.686E-15 4.843E-13 2.179E-12 4.843E-13 6 52
2 GO:0003729 mRNA binding 5.271E-14 1.318E-12 5.929E-12 2.636E-12 7 179
3 GO:1990715 mRNA CDS binding 9.645E-7 1.608E-5 7.233E-5 4.823E-5 2 4
4 GO:1990247 N6-methyladenosine-containing RNA binding 3.374E-6 4.217E-5 1.897E-4 1.687E-4 2 7
5 GO:0097157 pre-mRNA intronic binding 4.497E-6 4.497E-5 2.023E-4 2.249E-4 2 8
6 GO:0035198 miRNA binding 2.180E-5 1.752E-4 7.880E-4 1.090E-3 2 17
7 GO:0008266 poly(U) RNA binding 2.452E-5 1.752E-4 7.880E-4 1.226E-3 2 18
8 GO:0008187 poly-pyrimidine tract binding 3.699E-5 2.250E-4 1.012E-3 1.850E-3 2 22
9 GO:0017091 AU-rich element binding 4.050E-5 2.250E-4 1.012E-3 2.025E-3 2 23
10 GO:0036002 pre-mRNA binding 4.801E-5 2.400E-4 1.080E-3 2.400E-3 2 25
11 GO:0042162 telomeric DNA binding 7.432E-5 3.378E-4 1.520E-3 3.716E-3 2 31
12 GO:1990827 deaminase binding 4.287E-4 1.786E-3 8.037E-3 2.144E-2 1 1
13 GO:0003727 single-stranded RNA binding 5.123E-4 1.970E-3 8.865E-3 2.562E-2 2 81
14 GO:0043021 ribonucleoprotein complex binding 1.120E-3 3.998E-3 1.799E-2
5.598E-2
 2 120
15 GO:1990825 sequence-specific mRNA binding 1.286E-3 4.018E-3 1.808E-2
6.428E-2
 1 3
16 GO:0001069 regulatory region RNA binding 1.286E-3 4.018E-3 1.808E-2
6.428E-2
 1 3
17 GO:0033592 RNA strand annealing activity 1.714E-3 5.041E-3 2.268E-2
8.569E-2
 1 4
18 GO:0002151 G-quadruplex RNA binding 2.998E-3 8.326E-3 3.746E-2
1.499E-1
 1 7
19 GO:0034046 poly(G) binding 3.425E-3 8.563E-3 3.853E-2
1.713E-1
 1 8
20 GO:0035197 siRNA binding 3.425E-3 8.563E-3 3.853E-2
1.713E-1
 1 8
21 GO:0003680 AT DNA binding 3.853E-3 8.756E-3 3.939E-2
1.926E-1
 1 9
22 GO:0035925 mRNA 3'-UTR AU-rich region binding 3.853E-3 8.756E-3 3.939E-2
1.926E-1
 1 9
23 GO:0035613 RNA stem-loop binding 4.280E-3 8.916E-3 4.012E-2
2.140E-1
 1 10
24 GO:0043047 single-stranded telomeric DNA binding 4.280E-3 8.916E-3 4.012E-2
2.140E-1
 1 10
25 GO:0048027 mRNA 5'-UTR binding 4.707E-3 9.414E-3 4.235E-2
2.353E-1
 1 11
26 GO:0097617 annealing activity 5.134E-3 9.507E-3 4.277E-2
2.567E-1
 1 12
27 GO:0098847 sequence-specific single stranded DNA binding 5.134E-3 9.507E-3 4.277E-2
2.567E-1
 1 12
28 GO:0070034 telomerase RNA binding 5.987E-3 1.069E-2 4.810E-2
2.994E-1
 1 14
29 GO:0030371 translation repressor activity 9.820E-3 1.693E-2
7.617E-2
4.910E-1
 1 23
30 GO:0070717 poly-purine tract binding 1.067E-2 1.778E-2
8.001E-2
5.335E-1
 1 25
31 GO:0031492 nucleosomal DNA binding 1.279E-2 2.063E-2
9.282E-2
6.396E-1
 1 30
32 GO:0031369 translation initiation factor binding 1.491E-2 2.330E-2
1.048E-1
7.455E-1
 1 35
33 GO:0045182 translation regulator activity 1.787E-2 2.707E-2
1.218E-1
8.934E-1
 1 42
34 GO:0031491 nucleosome binding 1.913E-2 2.814E-2
1.266E-1
9.567E-1
 1 45
35 GO:0035064 methylated histone binding 2.292E-2 3.183E-2
1.432E-1
1.000E0
 1 54
36 GO:0043022 ribosome binding 2.292E-2 3.183E-2
1.432E-1
1.000E0
 1 54
37 GO:0003725 double-stranded RNA binding 2.879E-2 3.890E-2
1.750E-1
1.000E0
 1 68
38 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 3.004E-2 3.953E-2
1.778E-1
1.000E0
 1 71
39 GO:0031490 chromatin DNA binding 3.587E-2 4.599E-2
2.069E-1
1.000E0
 1 85
40 GO:0001158 enhancer sequence-specific DNA binding 3.919E-2 4.898E-2
2.204E-1
1.000E0
 1 93
Show 35 more annotations

2: GO: Biological Process [Display Chart] 8 input genes in category / 343 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000398 mRNA splicing, via spliceosome 2.329E-12 2.919E-10 1.873E-9 7.987E-10 7 305
2 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 2.329E-12 2.919E-10 1.873E-9 7.987E-10 7 305
3 GO:0000375 RNA splicing, via transesterification reactions 2.553E-12 2.919E-10 1.873E-9 8.756E-10 7 309
4 GO:0008380 RNA splicing 1.629E-11 1.397E-9 8.962E-9 5.587E-9 7 402
5 GO:0010608 posttranscriptional regulation of gene expression 5.262E-11 3.190E-9 2.047E-8 1.805E-8 7 475
6 GO:0006397 mRNA processing 5.581E-11 3.190E-9 2.047E-8 1.914E-8 7 479
7 GO:1903311 regulation of mRNA metabolic process 8.449E-10 4.140E-8 2.656E-7 2.898E-7 5 130
8 GO:0043488 regulation of mRNA stability 1.417E-9 6.075E-8 3.898E-7 4.860E-7 5 144
9 GO:0043487 regulation of RNA stability 1.627E-9 6.202E-8 3.979E-7 5.582E-7 5 148
10 GO:0006417 regulation of translation 1.167E-7 4.004E-6 2.569E-5 4.004E-5 5 347
11 GO:0034248 regulation of cellular amide metabolic process 1.835E-7 5.721E-6 3.671E-5 6.293E-5 5 380
12 GO:0017148 negative regulation of translation 2.409E-7 6.886E-6 4.418E-5 8.263E-5 4 145
13 GO:0034249 negative regulation of cellular amide metabolic process 3.068E-7 8.095E-6 5.194E-5 1.052E-4 4 154
14 GO:0048255 mRNA stabilization 3.690E-7 9.041E-6 5.801E-5 1.266E-4 3 36
15 GO:0043489 RNA stabilization 4.015E-7 9.181E-6 5.891E-5 1.377E-4 3 37
16 GO:1902416 positive regulation of mRNA binding 4.843E-7 1.038E-5 6.662E-5 1.661E-4 2 3
17 GO:1903312 negative regulation of mRNA metabolic process 6.834E-7 1.379E-5 8.848E-5 2.344E-4 3 44
18 GO:1902415 regulation of mRNA binding 1.614E-6 3.075E-5 1.973E-4 5.535E-4 2 5
19 GO:0048024 regulation of mRNA splicing, via spliceosome 2.933E-6 5.295E-5 3.398E-4 1.006E-3 3 71
20 GO:0045727 positive regulation of translation 9.831E-6 1.686E-4 1.082E-3 3.372E-3 3 106
21 GO:0043484 regulation of RNA splicing 1.069E-5 1.746E-4 1.121E-3 3.667E-3 3 109
22 GO:0050684 regulation of mRNA processing 1.129E-5 1.761E-4 1.130E-3 3.873E-3 3 111
23 GO:0070935 3'-UTR-mediated mRNA stabilization 1.466E-5 2.095E-4 1.344E-3 5.027E-3 2 14
24 GO:0061157 mRNA destabilization 1.466E-5 2.095E-4 1.344E-3 5.027E-3 2 14
25 GO:0034250 positive regulation of cellular amide metabolic process 1.613E-5 2.213E-4 1.420E-3 5.533E-3 3 125
26 GO:0050779 RNA destabilization 2.189E-5 2.888E-4 1.853E-3 7.508E-3 2 17
27 GO:0048025 negative regulation of mRNA splicing, via spliceosome 5.221E-5 6.633E-4 4.256E-3 1.791E-2 2 26
28 GO:0033119 negative regulation of RNA splicing 7.462E-5 9.141E-4 5.865E-3 2.559E-2 2 31
29 GO:0000381 regulation of alternative mRNA splicing, via spliceosome 1.010E-4 1.194E-3 7.664E-3 3.464E-2 2 36
30 GO:0050686 negative regulation of mRNA processing 1.067E-4 1.220E-3 7.830E-3 3.661E-2 2 37
31 GO:0000380 alternative mRNA splicing, via spliceosome 1.729E-4 1.913E-3 1.227E-2
5.930E-2
 2 47
32 GO:0035195 gene silencing by miRNA 2.371E-4 2.541E-3 1.631E-2
8.132E-2
 2 55
33 GO:0016441 posttranscriptional gene silencing 2.729E-4 2.753E-3 1.767E-2
9.361E-2
 2 59
34 GO:0035194 posttranscriptional gene silencing by RNA 2.729E-4 2.753E-3 1.767E-2
9.361E-2
 2 59
35 GO:1901254 positive regulation of intracellular transport of viral material 4.296E-4 3.778E-3 2.424E-2
1.473E-1
 1 1
36 GO:1990828 hepatocyte dedifferentiation 4.296E-4 3.778E-3 2.424E-2
1.473E-1
 1 1
37 GO:1904585 response to putrescine 4.296E-4 3.778E-3 2.424E-2
1.473E-1
 1 1
38 GO:1990428 miRNA transport 4.296E-4 3.778E-3 2.424E-2
1.473E-1
 1 1
39 GO:1904586 cellular response to putrescine 4.296E-4 3.778E-3 2.424E-2
1.473E-1
 1 1
40 GO:1900453 negative regulation of long-term synaptic depression 8.590E-4 6.852E-3 4.396E-2
2.946E-1
 1 2
41 GO:0044830 modulation by host of viral RNA genome replication 8.590E-4 6.852E-3 4.396E-2
2.946E-1
 1 2
42 GO:1904383 response to sodium phosphate 8.590E-4 6.852E-3 4.396E-2
2.946E-1
 1 2
43 GO:1901355 response to rapamycin 8.590E-4 6.852E-3 4.396E-2
2.946E-1
 1 2
44 GO:0043697 cell dedifferentiation 1.288E-3 9.206E-3
5.907E-2
4.419E-1
 1 3
45 GO:0090367 negative regulation of mRNA modification 1.288E-3 9.206E-3
5.907E-2
4.419E-1
 1 3
46 GO:0014076 response to fluoxetine 1.288E-3 9.206E-3
5.907E-2
4.419E-1
 1 3
47 GO:0043696 dedifferentiation 1.288E-3 9.206E-3
5.907E-2
4.419E-1
 1 3
48 GO:1901252 regulation of intracellular transport of viral material 1.288E-3 9.206E-3
5.907E-2
4.419E-1
 1 3
49 GO:0000723 telomere maintenance 1.525E-3 1.068E-2
6.851E-2
5.232E-1
 2 140
50 GO:0097167 circadian regulation of translation 1.717E-3 1.155E-2
7.408E-2
5.890E-1
 1 4
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 8 input genes in category / 62 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0071598 neuronal ribonucleoprotein granule 2.310E-6 1.432E-4 6.750E-4 1.432E-4 2 6
2 GO:0071013 catalytic step 2 spliceosome 5.604E-6 1.737E-4 8.186E-4 3.474E-4 3 90
3 GO:0035770 ribonucleoprotein granule 2.704E-5 4.935E-4 2.325E-3 1.676E-3 3 152
4 GO:0045120 pronucleus 3.224E-5 4.935E-4 2.325E-3 1.999E-3 2 21
5 GO:0005681 spliceosomal complex 3.979E-5 4.935E-4 2.325E-3 2.467E-3 3 173
6 GO:0032838 plasma membrane bounded cell projection cytoplasm 2.972E-4 2.891E-3 1.362E-2 1.843E-2 2 63
7 GO:0044094 host cell nuclear part 4.197E-4 2.891E-3 1.362E-2 2.602E-2 1 1
8 GO:1990826 nucleoplasmic periphery of the nuclear pore complex 4.197E-4 2.891E-3 1.362E-2 2.602E-2 1 1
9 GO:0019034 viral replication complex 4.197E-4 2.891E-3 1.362E-2 2.602E-2 1 1
10 GO:1902737 dendritic filopodium 8.393E-4 4.730E-3 2.229E-2
5.203E-2
 1 2
11 GO:0042025 host cell nucleus 8.393E-4 4.730E-3 2.229E-2
5.203E-2
 1 2
12 GO:1990812 growth cone filopodium 1.259E-3 6.502E-3 3.064E-2
7.804E-2
 1 3
13 GO:0043204 perikaryon 1.498E-3 6.502E-3 3.064E-2
9.290E-2
 2 142
14 GO:0036464 cytoplasmic ribonucleoprotein granule 1.540E-3 6.502E-3 3.064E-2
9.550E-2
 2 144
15 GO:0033647 host intracellular organelle 1.678E-3 6.502E-3 3.064E-2
1.040E-1
 1 4
16 GO:0033648 host intracellular membrane-bounded organelle 1.678E-3 6.502E-3 3.064E-2
1.040E-1
 1 4
17 GO:0030426 growth cone 2.445E-3 8.414E-3 3.965E-2
1.516E-1
 2 182
18 GO:0043679 axon terminus 2.551E-3 8.414E-3 3.965E-2
1.582E-1
 2 186
19 GO:0030427 site of polarized growth 2.578E-3 8.414E-3 3.965E-2
1.599E-1
 2 187
20 GO:0044306 neuron projection terminus 2.914E-3 9.032E-3 4.256E-2
1.806E-1
 2 199
21 GO:0042788 polysomal ribosome 3.353E-3 9.900E-3 4.665E-2
2.079E-1
 1 8
22 GO:0005845 mRNA cap binding complex 5.026E-3 1.298E-2
6.119E-2
3.116E-1
 1 12
23 GO:0043656 intracellular region of host 5.026E-3 1.298E-2
6.119E-2
3.116E-1
 1 12
24 GO:0033646 host intracellular part 5.026E-3 1.298E-2
6.119E-2
3.116E-1
 1 12
25 GO:0032797 SMN complex 5.444E-3 1.346E-2
6.343E-2
3.375E-1
 1 13
26 GO:0033643 host cell part 5.862E-3 1.346E-2
6.343E-2
3.634E-1
 1 14
27 GO:0034518 RNA cap binding complex 5.862E-3 1.346E-2
6.343E-2
3.634E-1
 1 14
28 GO:0032433 filopodium tip 6.279E-3 1.390E-2
6.552E-2
3.893E-1
 1 15
29 GO:0033267 axon part 6.876E-3 1.408E-2
6.635E-2
4.263E-1
 2 309
30 GO:0010369 chromocenter 7.114E-3 1.408E-2
6.635E-2
4.411E-1
 1 17
31 GO:0097386 glial cell projection 7.531E-3 1.408E-2
6.635E-2
4.669E-1
 1 18
32 GO:0099568 cytoplasmic region 7.583E-3 1.408E-2
6.635E-2
4.701E-1
 2 325
33 GO:0018995 host 7.948E-3 1.408E-2
6.635E-2
4.928E-1
 1 19
34 GO:0005697 telomerase holoenzyme complex 7.948E-3 1.408E-2
6.635E-2
4.928E-1
 1 19
35 GO:0043657 host cell 7.948E-3 1.408E-2
6.635E-2
4.928E-1
 1 19
36 GO:0044217 other organism part 1.003E-2 1.637E-2
7.712E-2
6.219E-1
 1 24
37 GO:0044216 other organism cell 1.003E-2 1.637E-2
7.712E-2
6.219E-1
 1 24
38 GO:0044215 other organism 1.003E-2 1.637E-2
7.712E-2
6.219E-1
 1 24
39 GO:0010494 cytoplasmic stress granule 1.418E-2 2.255E-2
1.063E-1
8.794E-1
 1 34
40 GO:0000785 chromatin 1.647E-2 2.553E-2
1.203E-1
1.000E0
 2 487
41 GO:0005844 polysome 2.039E-2 3.083E-2
1.453E-1
1.000E0
 1 49
42 GO:0015030 Cajal body 2.244E-2 3.313E-2
1.561E-1
1.000E0
 1 54
43 GO:0043198 dendritic shaft 2.491E-2 3.592E-2
1.693E-1
1.000E0
 1 60
Show 38 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 225 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0030216 Inertia 8.497E-4 4.779E-2
2.865E-1
1.912E-1
 1 2
2 HP:0008640 Congenital macroorchidism 8.497E-4 4.779E-2
2.865E-1
1.912E-1
 1 2
3 HP:0003564 Folate-dependent fragile site at Xq28 8.497E-4 4.779E-2
2.865E-1
1.912E-1
 1 2
4 HP:0100515 Pollakisuria 1.274E-3 4.779E-2
2.865E-1
2.867E-1
 1 3
5 HP:0002050 Macroorchidism, postpubertal 1.274E-3 4.779E-2
2.865E-1
2.867E-1
 1 3
6 HP:0100275 Diffuse cerebellar atrophy 1.274E-3 4.779E-2
2.865E-1
2.867E-1
 1 3
Show 1 more annotation

5: Mouse Phenotype [Display Chart] 5 input genes in category / 196 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 8 input genes in category / 26 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00076 RRM 1 Pfam 1.489E-13 1.974E-12 7.610E-12 3.873E-12 7 208
2 SM00360 RRM SMART 2.011E-13 1.974E-12 7.610E-12 5.229E-12 7 217
3 IPR000504 RRM dom InterPro 2.768E-13 1.974E-12 7.610E-12 7.196E-12 7 227
4 PS50102 RRM PROSITE 3.037E-13 1.974E-12 7.610E-12 7.897E-12 7 230
5 3.30.70.330 - Gene3D 4.615E-13 2.400E-12 9.250E-12 1.200E-11 7 244
6 IPR012677 Nucleotide-bd a/b plait InterPro 6.848E-13 2.967E-12 1.144E-11 1.780E-11 7 258
7 IPR012956 CARG-binding factor N InterPro 1.596E-7 5.185E-7 1.999E-6 4.148E-6 2 2
8 PF08143 CBFNT Pfam 1.596E-7 5.185E-7 1.999E-6 4.148E-6 2 2
9 PF16098 FXMR C2 Pfam 4.270E-4 1.110E-3 4.279E-3 1.110E-2 1 1
10 IPR032196 FXMR C2 InterPro 4.270E-4 1.110E-3 4.279E-3 1.110E-2 1 1
11 PS51641 AGENET LIKE PROSITE 1.281E-3 1.958E-3 7.549E-3 3.329E-2 1 3
12 IPR021662 HnRNPA1 InterPro 1.281E-3 1.958E-3 7.549E-3 3.329E-2 1 3
13 IPR008395 Agenet-like dom InterPro 1.281E-3 1.958E-3 7.549E-3 3.329E-2 1 3
14 PF12235 FXMRP1 C core Pfam 1.281E-3 1.958E-3 7.549E-3 3.329E-2 1 3
15 PF05641 Agenet Pfam 1.281E-3 1.958E-3 7.549E-3 3.329E-2 1 3
16 PF11627 HnRNPA1 Pfam 1.281E-3 1.958E-3 7.549E-3 3.329E-2 1 3
17 IPR022034 FXMRP1 C core InterPro 1.281E-3 1.958E-3 7.549E-3 3.329E-2 1 3
18 IPR006535 HnRNP R/Q splicing fac InterPro 2.133E-3 2.919E-3 1.125E-2
5.547E-2
 1 5
19 IPR006536 HnRNP-L/PTB InterPro 2.133E-3 2.919E-3 1.125E-2
5.547E-2
 1 5
20 IPR017347 hnRNP C InterPro 2.560E-3 3.328E-3 1.283E-2
6.655E-2
 1 6
21 PF00013 KH 1 Pfam 1.611E-2 1.837E-2
7.080E-2
4.190E-1
 1 38
22 3.30.1370.10 - Gene3D 1.654E-2 1.837E-2
7.080E-2
4.299E-1
 1 39
23 IPR004087 KH dom InterPro 1.696E-2 1.837E-2
7.080E-2
4.409E-1
 1 40
24 SM00322 KH SMART 1.696E-2 1.837E-2
7.080E-2
4.409E-1
 1 40
25 PS50084 KH TYPE 1 PROSITE 1.780E-2 1.851E-2
7.134E-2
4.627E-1
 1 42
26 IPR004088 KH dom type 1 InterPro 1.864E-2 1.864E-2
7.184E-2
4.846E-1
 1 44
Show 21 more annotations

7: Pathway [Display Chart] 7 input genes in category / 11 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269690 mRNA Splicing - Major Pathway BioSystems: REACTOME 7.570E-11 5.361E-10 1.619E-9 8.327E-10 6 188
2 1269689 mRNA Splicing BioSystems: REACTOME 9.747E-11 5.361E-10 1.619E-9 1.072E-9 6 196
3 1269688 Processing of Capped Intron-Containing Pre-mRNA BioSystems: REACTOME 4.051E-10 1.485E-9 4.486E-9 4.456E-9 6 248

8: Pubmed [Display Chart] 8 input genes in category / 1762 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17289661 Molecular composition of IMP1 ribonucleoprotein granules. Pubmed 1.264E-17 2.227E-14 1.793E-13 2.227E-14 6 36
2 26641092 The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells. Pubmed 2.738E-15 2.367E-12 1.906E-11 4.824E-12 7 239
3 23151878 Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. Pubmed 4.030E-15 2.367E-12 1.906E-11 7.101E-12 6 90
4 21942715 Proteomic dissection of the von Hippel-Lindau (VHL) interactome. Pubmed 6.811E-15 3.000E-12 2.416E-11 1.200E-11 6 98
5 16033648 A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. Pubmed 9.513E-15 3.353E-12 2.699E-11 1.676E-11 7 285
6 12226669 Comprehensive proteomic analysis of the human spliceosome. Pubmed 1.310E-14 3.846E-12 3.097E-11 2.308E-11 6 109
7 25324306 hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. Pubmed 3.742E-14 9.418E-12 7.583E-11 6.593E-11 7 346
8 23825951 Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing. Pubmed 5.430E-14 1.196E-11 9.629E-11 9.568E-11 5 40
9 17643375 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Pubmed 8.701E-14 1.703E-11 1.372E-10 1.533E-10 7 390
10 21642987 IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Pubmed 3.777E-13 6.655E-11 5.358E-10 6.655E-10 5 58
11 22623428 Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment. Pubmed 4.401E-13 7.049E-11 5.676E-10 7.754E-10 7 491
12 12456657 Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. Pubmed 1.436E-12 2.108E-10 1.697E-9 2.530E-9 4 16
13 23125841 Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1. Pubmed 1.643E-12 2.227E-10 1.793E-9 2.895E-9 6 241
14 12388589 A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. Pubmed 1.877E-12 2.363E-10 1.902E-9 3.308E-9 4 17
15 20000738 Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma. Pubmed 6.845E-12 8.041E-10 6.475E-9 1.206E-8 5 102
16 24332808 PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Pubmed 1.314E-11 1.447E-9 1.165E-8 2.315E-8 6 340
17 15782174 Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. Pubmed 2.159E-11 2.238E-9 1.802E-8 3.805E-8 4 30
18 26805816 Unraveling Molecular Differences of Gastric Cancer by Label-Free Quantitative Proteomics Analysis. Pubmed 2.412E-11 2.361E-9 1.901E-8 4.251E-8 3 4
19 15848144 Proteomic analysis of complexes formed by human topoisomerase I. Pubmed 2.833E-11 2.627E-9 2.115E-8 4.992E-8 4 32
20 23000965 Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Pubmed 4.847E-11 4.206E-9 3.386E-8 8.540E-8 5 150
21 18457437 Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry. Pubmed 5.013E-11 4.206E-9 3.386E-8 8.832E-8 5 151
22 26336360 Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis. Pubmed 5.910E-11 4.733E-9 3.811E-8 1.041E-7 5 156
23 22751105 Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. Pubmed 6.507E-11 4.985E-9 4.014E-8 1.147E-7 5 159
24 26265008 Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Pubmed 9.713E-11 7.131E-9 5.742E-8 1.712E-7 4 43
25 26831064 CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly. Pubmed 1.244E-10 8.771E-9 7.062E-8 2.193E-7 6 494
26 21906983 Systematic and quantitative assessment of the ubiquitin-modified proteome. Pubmed 1.642E-10 1.113E-8 8.959E-8 2.893E-7 5 191
27 21890473 A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Pubmed 1.776E-10 1.159E-8 9.332E-8 3.129E-7 5 194
28 7768196 The biogenesis of the coiled body during early mouse development. Pubmed 2.110E-10 1.294E-8 1.042E-7 3.718E-7 3 7
29 24591637 Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer. Pubmed 2.129E-10 1.294E-8 1.042E-7 3.752E-7 4 52
30 22174317 Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. Pubmed 2.403E-10 1.411E-8 1.136E-7 4.234E-7 5 206
31 20020773 Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Pubmed 3.582E-10 2.036E-8 1.639E-7 6.311E-7 5 223
32 25900982 BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates. Pubmed 3.831E-10 2.109E-8 1.698E-7 6.750E-7 5 226
33 23246001 SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. Pubmed 5.075E-10 2.710E-8 2.182E-7 8.942E-7 5 239
34 21182205 Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. Pubmed 5.748E-10 2.979E-8 2.399E-7 1.013E-6 5 245
35 26990986 Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Pubmed 1.305E-9 6.571E-8 5.291E-7 2.300E-6 4 81
36 22446626 DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. Pubmed 1.914E-9 9.358E-8 7.535E-7 3.373E-6 4 89
37 16196087 Large-scale analysis of the human ubiquitin-related proteome. Pubmed 1.965E-9 9.358E-8 7.535E-7 3.462E-6 5 313
38 17620599 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Pubmed 2.094E-9 9.710E-8 7.819E-7 3.690E-6 5 317
39 25948554 Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations. Pubmed 2.603E-9 1.176E-7 9.469E-7 4.587E-6 4 96
40 17332742 Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. Pubmed 5.409E-9 2.382E-7 1.918E-6 9.530E-6 4 115
41 20850016 Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Pubmed 7.334E-9 3.152E-7 2.538E-6 1.292E-5 4 124
42 22505724 Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Pubmed 8.875E-9 3.666E-7 2.952E-6 1.564E-5 4 130
43 21081503 RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. Pubmed 9.080E-9 3.666E-7 2.952E-6 1.600E-5 5 425
44 28031328 Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage. Pubmed 9.154E-9 3.666E-7 2.952E-6 1.613E-5 4 131
45 20975687 TERRA transcripts are bound by a complex array of RNA-binding proteins. Pubmed 1.218E-8 4.770E-7 3.841E-6 2.147E-5 3 24
46 24816145 A COFRADIC protocol to study protein ubiquitination. Pubmed 1.998E-8 7.654E-7 6.163E-6 3.521E-5 4 159
47 21963094 Global identification of modular cullin-RING ligase substrates. Pubmed 2.154E-8 8.077E-7 6.503E-6 3.796E-5 4 162
48 22178446 Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Pubmed 2.442E-8 8.965E-7 7.219E-6 4.303E-5 3 30
49 23184937 Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. Pubmed 2.741E-8 9.858E-7 7.937E-6 4.830E-5 4 172
50 18850631 Interaction proteomics of the HMGA chromatin architectural factors. Pubmed 2.983E-8 1.051E-6 8.464E-6 5.256E-5 3 32
Show 45 more annotations

9: Interaction [Display Chart] 8 input genes in category / 2369 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:KHDRBS2 KHDRBS2 interactions 9.852E-13 1.740E-9 1.453E-8 2.334E-9 6 104
2 int:IL7R IL7R interactions 1.469E-12 1.740E-9 1.453E-8 3.480E-9 6 111
3 int:HNRNPD HNRNPD interactions 2.686E-12 2.121E-9 1.770E-8 6.362E-9 7 296
4 int:STAU1 STAU1 interactions 1.088E-11 6.445E-9 5.380E-8 2.578E-8 7 361
5 int:U2AF2 U2AF2 interactions 2.014E-11 9.543E-9 7.966E-8 4.771E-8 7 394
6 int:FBXW11 FBXW11 interactions 2.665E-11 1.016E-8 8.480E-8 6.313E-8 7 410
7 int:PCBP1 PCBP1 interactions 3.002E-11 1.016E-8 8.480E-8 7.111E-8 7 417
8 int:MEPCE MEPCE interactions 4.010E-11 1.188E-8 9.914E-8 9.501E-8 6 191
9 int:CUL5 CUL5 interactions 5.207E-11 1.370E-8 1.144E-7 1.233E-7 7 451
10 int:IVNS1ABP IVNS1ABP interactions 1.985E-10 4.702E-8 3.925E-7 4.702E-7 5 93
11 int:PTBP2 PTBP2 interactions 2.548E-10 5.487E-8 4.581E-7 6.036E-7 4 26
12 int:NEDD8 NEDD8 interactions 3.324E-10 6.562E-8 5.478E-7 7.874E-7 6 271
13 int:RALY RALY interactions 3.682E-10 6.709E-8 5.600E-7 8.722E-7 5 105
14 int:HNRNPH1 HNRNPH1 interactions 4.503E-10 7.620E-8 6.361E-7 1.067E-6 6 285
15 int:MATR3 MATR3 interactions 5.891E-10 9.304E-8 7.766E-7 1.396E-6 6 298
16 int:SCARNA22 SCARNA22 interactions 6.659E-10 9.859E-8 8.230E-7 1.577E-6 5 118
17 int:ELAVL2 ELAVL2 interactions 7.562E-10 1.054E-7 8.797E-7 1.791E-6 5 121
18 int:HNRNPDL HNRNPDL interactions 1.005E-9 1.323E-7 1.105E-6 2.382E-6 5 128
19 int:VHL VHL interactions 1.867E-9 2.324E-7 1.940E-6 4.422E-6 6 361
20 int:TARDBP TARDBP interactions 1.962E-9 2.324E-7 1.940E-6 4.648E-6 6 364
21 int:ARRB2 ARRB2 interactions 2.923E-9 3.261E-7 2.722E-6 6.925E-6 6 389
22 int:IFIT2 IFIT2 interactions 3.028E-9 3.261E-7 2.722E-6 7.174E-6 4 47
23 int:RPA3 RPA3 interactions 3.891E-9 4.008E-7 3.346E-6 9.218E-6 6 408
24 int:HNRNPA0 HNRNPA0 interactions 6.446E-9 6.363E-7 5.312E-6 1.527E-5 5 185
25 int:VCAM1 VCAM1 interactions 7.578E-9 7.181E-7 5.994E-6 1.795E-5 6 456
26 int:CUL2 CUL2 interactions 8.519E-9 7.762E-7 6.479E-6 2.018E-5 6 465
27 int:RPA2 RPA2 interactions 9.082E-9 7.969E-7 6.652E-6 2.152E-5 6 470
28 int:HNRNPK HNRNPK interactions 1.253E-8 1.024E-6 8.547E-6 2.969E-5 6 496
29 int:RPA1 RPA1 interactions 1.269E-8 1.024E-6 8.547E-6 3.005E-5 6 497
30 int:MIR9-3 MIR9-3 interactions 1.297E-8 1.024E-6 8.547E-6 3.072E-5 4 67
31 int:MIR138-1 MIR138-1 interactions 1.377E-8 1.053E-6 8.787E-6 3.263E-5 4 68
32 int:MIR140 MIR140 interactions 1.462E-8 1.082E-6 9.034E-6 3.463E-5 4 69
33 int:MIR29B2 MIR29B2 interactions 1.642E-8 1.105E-6 9.222E-6 3.891E-5 4 71
34 int:MIR122 MIR122 interactions 1.642E-8 1.105E-6 9.222E-6 3.891E-5 4 71
35 int:IFIT3 IFIT3 interactions 1.739E-8 1.105E-6 9.222E-6 4.119E-5 4 72
36 int:MIR29B1 MIR29B1 interactions 1.839E-8 1.105E-6 9.222E-6 4.357E-5 4 73
37 int:MIR18A MIR18A interactions 1.839E-8 1.105E-6 9.222E-6 4.357E-5 4 73
38 int:MIR20A MIR20A interactions 1.944E-8 1.105E-6 9.222E-6 4.605E-5 4 74
39 int:MIR16-1 MIR16-1 interactions 1.944E-8 1.105E-6 9.222E-6 4.605E-5 4 74
40 int:MIR15A MIR15A interactions 1.944E-8 1.105E-6 9.222E-6 4.605E-5 4 74
41 int:PTBP1 PTBP1 interactions 2.008E-8 1.105E-6 9.222E-6 4.757E-5 5 232
42 int:MIR199A2 MIR199A2 interactions 2.167E-8 1.105E-6 9.222E-6 5.133E-5 4 76
43 int:MIR7-3 MIR7-3 interactions 2.167E-8 1.105E-6 9.222E-6 5.133E-5 4 76
44 int:MIR222 MIR222 interactions 2.167E-8 1.105E-6 9.222E-6 5.133E-5 4 76
45 int:MIR429 MIR429 interactions 2.167E-8 1.105E-6 9.222E-6 5.133E-5 4 76
46 int:MIR92A1 MIR92A1 interactions 2.285E-8 1.105E-6 9.222E-6 5.414E-5 4 77
47 int:MIR451A MIR451A interactions 2.285E-8 1.105E-6 9.222E-6 5.414E-5 4 77
48 int:MIR9-2 MIR9-2 interactions 2.285E-8 1.105E-6 9.222E-6 5.414E-5 4 77
49 int:MIR200A MIR200A interactions 2.285E-8 1.105E-6 9.222E-6 5.414E-5 4 77
50 int:MIR98 MIR98 interactions 2.408E-8 1.134E-6 9.463E-6 5.705E-5 4 78
Show 45 more annotations

10: Cytoband [Display Chart] 8 input genes in category / 8 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7p15 7p15 3.687E-3 1.885E-2
5.123E-2
 2.950E-2 1 16
2 4q21 4q21 4.837E-3 1.885E-2
5.123E-2
 3.870E-2 1 21
3 1p36.12 1p36.12 8.967E-3 1.885E-2
5.123E-2
7.174E-2
 1 39
4 Xq27.3 Xq27.3 9.425E-3 1.885E-2
5.123E-2
7.540E-2
 1 41
5 5q35.3 5q35.3 2.330E-2 3.499E-2
9.509E-2
1.864E-1
 1 102
6 5q31 5q31 2.624E-2 3.499E-2
9.509E-2
2.099E-1
 1 115
7 19q13.2 19q13.2 3.835E-2 4.258E-2
1.157E-1
3.068E-1
 1 169
8 14q11.2 14q11.2 4.258E-2 4.258E-2
1.157E-1
3.406E-1
 1 188
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 164 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 YGCGYRCGC UNKNOWN YGCGYRCGC UNKNOWN 4.620E-7 7.576E-5 4.303E-4 7.576E-5 5 241
2 V$E2F1 Q6 V$E2F1 Q6 3.270E-4 1.523E-2
8.651E-2
5.364E-2
 3 181
3 V$E2F 02 V$E2F 02 3.433E-4 1.523E-2
8.651E-2
5.630E-2
 3 184
4 V$E2F4DP1 01 V$E2F4DP1 01 3.715E-4 1.523E-2
8.651E-2
6.092E-2
 3 189
5 RRCCGTTA UNKNOWN RRCCGTTA UNKNOWN 1.014E-3 3.326E-2
1.889E-1
1.663E-1
 2 60

12: Gene Family [Display Chart] 7 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 725 RNA binding motif containing genenames.org 2.731E-14 2.731E-14 2.731E-14 2.731E-14 7 213

13: Coexpression [Display Chart] 8 input genes in category / 758 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18535662-TableS2b Mouse Lymphoma Wu08 1016genes GeneSigDB 1.619E-9 1.227E-6 8.845E-6 1.227E-6 6 460
2 M5926 A subgroup of genes regulated by MYC - version 1 (v1). MSigDB H: Hallmark Gene Sets (v6.0) 3.691E-7 1.399E-4 1.008E-3 2.798E-4 4 200
3 M3898 Genes down-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.249E-5 3.155E-3 2.274E-2 9.465E-3 4 485
4 M3441 Genes up-regulated in comparison of intrathymic T progenitor cells (ITTP) versus naive CD4 [GeneID=920] T cells from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 3.451E-5 5.232E-3 3.772E-2 2.616E-2 3 200
5 M7436 Genes down-regulated in CD4 [GeneID=920] T cells: TGF beta versus TGF beta and IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 3.451E-5 5.232E-3 3.772E-2 2.616E-2 3 200
6 M15866 Genes up-regulated in endometroid endometrial tumors from patients with lymph node metastases compared to those without the metastases. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.222E-5 5.334E-3 3.845E-2 3.201E-2 3 214
7 M11318 Genes down-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164], a marine-derived compound with potential anti-cancer properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.627E-5 7.176E-3
5.173E-2
5.023E-2
 3 249
8 M5040 Human environmental stress response genes not changed in primary fibroblasts from Wilmor syndrom (WS) patients in response to 4NQO treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.106E-5 7.176E-3
5.173E-2
6.145E-2
 2 40
9 19014521-TableS6a Human Breast Reyal08 41genes GeneSigDB 8.521E-5 7.176E-3
5.173E-2
6.459E-2
 2 41
10 16636670-Table2 Human StemCell Pramoonjago06 50genes DownRegulated GeneSigDB 9.825E-5 7.447E-3
5.368E-2
7.447E-2
 2 44
11 M11665 Genes down-regulated in ACC3 cells (adenoid cystic carcinoma) after knockdown of SOX4 [GeneID=6659] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.323E-4 9.114E-3
6.570E-2
1.003E-1
 2 51
12 M13936 Genes down-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.625E-4 1.026E-2
7.397E-2
1.231E-1
 3 337
13 M1865 Up-regulated genes in the subpopulation of invasive PyMT cells (breast cancer) compared to the general population of PyMT cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.209E-4 1.288E-2
9.285E-2
1.674E-1
 3 374
14 16265353-SuppTable2 Human Bladder Aaboe05 86genes GeneSigDB 2.716E-4 1.367E-2
9.854E-2
2.059E-1
 2 73
15 M17481 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 7. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.944E-4 1.367E-2
9.854E-2
2.231E-1
 2 76
16 M1858 Down-regulated genes in A2780 cells (ovarian cancer) treated with 17AAG [PubChem=6440175], a chemical with anticancer properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.181E-4 1.367E-2
9.854E-2
2.411E-1
 2 79
17 12384544-Table2 Human Testicular Weinschenk02 98genes GeneSigDB 3.181E-4 1.367E-2
9.854E-2
2.411E-1
 2 79
18 M13893 Genes down-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [GeneID=921] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.353E-4 1.367E-2
9.854E-2
2.542E-1
 3 431
19 17665260-Table2 Human Colon Kim07 95genes GeneSigDB 3.427E-4 1.367E-2
9.854E-2
2.597E-1
 2 82
20 M14665 Genes up-regulated in lymphoblastoid cells from the European population compared to those from the Asian population. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.542E-4 1.680E-2
1.211E-1
3.443E-1
 3 478
21 15845616-SuppTable3 Mouse Uterine Jeong05 634genes GeneSigDB 4.654E-4 1.680E-2
1.211E-1
3.528E-1
 3 482
22 18535662-TableS1b Mouse Lymphoma Wu08 1114genes GeneSigDB 5.031E-4 1.733E-2
1.250E-1
3.814E-1
 3 495
23 M7995 Genes from 'subtype S2' signature of hepatocellular carcinoma (HCC): proliferation, MYC and AKT1 [GeneID=4609;207] activation. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.725E-4 2.148E-2
1.548E-1
5.097E-1
 2 115
24 M2179 Cluster 7 of aberrantly hypermethylated genes in blasts from AML (acute myeloid leukemia) patients. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.078E-4 2.148E-2
1.548E-1
5.365E-1
 2 118
25 M6866 Genes down-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668], a DNA hypomethylating agent similar to azacitidine [PubChem=9444]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.563E-4 2.148E-2
1.548E-1
5.733E-1
 2 122
26 15543619-Table2 Human Leukemia Edick05 05genes GeneSigDB 1.728E-3 2.148E-2
1.548E-1
1.000E0
 1 5
27 M6593 Genes down-regulated upon CSF1 [GeneID=1435] treatment: monocytes (3 days) versus macrophages (7 days). MSigDB C7: Immunologic Signatures (v6.0) 1.856E-3 2.148E-2
1.548E-1
1.000E0
 2 192
28 M6589 Genes down-regulated in monocytes versus alternatively activated (M2) macrophages. MSigDB C7: Immunologic Signatures (v6.0) 1.933E-3 2.148E-2
1.548E-1
1.000E0
 2 196
29 M7458 Genes down-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: medium versus IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 1.953E-3 2.148E-2
1.548E-1
1.000E0
 2 197
30 M8299 Genes down-regulated in thymocytes: double positive versus CD4 [GeneID=920] single positive. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 2.148E-2
1.548E-1
1.000E0
 2 199
31 M4176 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 48 h. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 2.148E-2
1.548E-1
1.000E0
 2 199
32 M6507 Genes down-regulated in monocyte-derived dendritic cells: LGALS1 [GeneID=3956] versus vehicle. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 2.148E-2
1.548E-1
1.000E0
 2 199
33 M3143 Genes down-regulated in comparison of macrophages cultured with M-CSF [GeneID=1435] and IFNG [GeneID=3458] versus macrophages cultured with M-CSF [GeneID=1435] and Pam3Cyc. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 2.148E-2
1.548E-1
1.000E0
 2 199
34 M6537 Genes up-regulated in epithelial cells (6h): interferon alpha versus interferon alpha and IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 2.148E-2
1.548E-1
1.000E0
 2 199
35 M9530 Genes down-regulated in skin: wildtype versus IL1R1 [GeneID=3554] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 2.148E-2
1.548E-1
1.000E0
 2 199
36 M6033 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (48h) versus untreated (48h). MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 2.148E-2
1.548E-1
1.000E0
 2 199
37 M9534 Genes up-regulated in skin: uninfected versus S. aureus infection. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 2.148E-2
1.548E-1
1.000E0
 2 199
38 M3337 Genes up-regulated in comparison of polysome bound (translated) mRNA before and 4 h after LPS (TLR4 agonist) stimulation. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 2.148E-2
1.548E-1
1.000E0
 2 199
39 M8319 Genes down-regulated in NKT cells: naïve versus activated. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 2.148E-2
1.548E-1
1.000E0
 2 200
40 M6202 Genes down-regulated in polymorphonuclear leukocytes (9h): control versus infection by A. phagocytophilum. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 2.148E-2
1.548E-1
1.000E0
 2 200
41 M5668 Genes up-regulated in comparison of untreated peripheral blood mononuclear cells (PBMC) versus PBMCs treated with CSF3 [GeneID=1440]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 2.148E-2
1.548E-1
1.000E0
 2 200
42 M4202 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 72 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 2.148E-2
1.548E-1
1.000E0
 2 200
43 M3850 Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 2.148E-2
1.548E-1
1.000E0
 2 200
44 M3459 Genes up-regulated in comparison of CD4 [GeneID=920] CD8 thymocytes versus naive CD4 [GeneID=920] T cells from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 2.148E-2
1.548E-1
1.000E0
 2 200
45 M7354 Genes up-regulated in HMC-1 (mast leukemia) cells: stimulated with T cell membranes versus incubated with the peptide ALL1 and then stimulated with T cell membranes. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 2.148E-2
1.548E-1
1.000E0
 2 200
46 M3175 Genes down-regulated in plasma cells versus naive B cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 2.148E-2
1.548E-1
1.000E0
 2 200
47 M7070 Genes down-regulated in NK cells: primary versus stimulated by high dose of IL2 [GeneID=3558]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 2.148E-2
1.548E-1
1.000E0
 2 200
48 M6194 Genes up-regulated in polymorphonuclear leukocytes (9h) infection by A. phagocytophilum: heat killed versus live bacteria. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 2.148E-2
1.548E-1
1.000E0
 2 200
49 M9041 Genes up-regulated in macrophages with knockout of HDAC3 [GeneID=8841] after LPS treatment: heterozygous versus homozygous. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 2.148E-2
1.548E-1
1.000E0
 2 200
50 M296 Genes up-regulated in allogeneic T cells after stimulation with dendritic cells from: peripheral lymph nodes (mLN) versus spleen. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 2.148E-2
1.548E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 8 input genes in category / 591 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ Lymphoid UNK Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ Lymphoid UNK Top 200 Genes 1.073E-8 6.341E-6 4.413E-5 6.341E-6 5 252
2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell Adult, Development, and Cancer types 2.205E-7 1.438E-5 1.001E-4 1.303E-4 4 166
3 Human Cell Atlas Human Cell Atlas Immune Immune Top 200 Human Cell Atlas Human Cell Atlas Immune Immune Top 200 2.782E-7 1.438E-5 1.001E-4 1.644E-4 5 484
4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal fetal kidney Junk/Kidney Normal fetal kidney IT1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal fetal kidney Junk/Kidney Normal fetal kidney IT1 Adult, Development, and Cancer types 3.331E-7 1.438E-5 1.001E-4 1.969E-4 4 184
5 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC2/Kidney Normal fetal kidney MNP RCC2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC2/Kidney Normal fetal kidney MNP RCC2 Adult, Development, and Cancer types 3.331E-7 1.438E-5 1.001E-4 1.969E-4 4 184
6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal fetal kidney Nephron epithelium/Kidney Normal fetal kidney PT1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal fetal kidney Nephron epithelium/Kidney Normal fetal kidney PT1 Adult, Development, and Cancer types 3.404E-7 1.438E-5 1.001E-4 2.012E-4 4 185
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal fetal kidney PT-U/Kidney Normal fetal kidney PT7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal fetal kidney PT-U/Kidney Normal fetal kidney PT7 Adult, Development, and Cancer types 3.404E-7 1.438E-5 1.001E-4 2.012E-4 4 185
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-G/Kidney Normal fetal kidney EN-G Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-G/Kidney Normal fetal kidney EN-G Adult, Development, and Cancer types 3.709E-7 1.438E-5 1.001E-4 2.192E-4 4 189
9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Cortex post-natal kidney Nephrogenesis/Kidney Normal-Cortex post-natal kidney F11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Cortex post-natal kidney Nephrogenesis/Kidney Normal-Cortex post-natal kidney F11 Adult, Development, and Cancer types 3.788E-7 1.438E-5 1.001E-4 2.239E-4 4 190
10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal fetal kidney Renal cell carcinoma Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal fetal kidney Renal cell carcinoma Adult, Development, and Cancer types 3.788E-7 1.438E-5 1.001E-4 2.239E-4 4 190
11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal fetal kidney Junk Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal fetal kidney Junk Adult, Development, and Cancer types 3.869E-7 1.438E-5 1.001E-4 2.286E-4 4 191
12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal fetal kidney Nephrogenesis Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal fetal kidney Nephrogenesis Adult, Development, and Cancer types 3.869E-7 1.438E-5 1.001E-4 2.286E-4 4 191
13 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R-U Adult, Development, and Cancer types 3.869E-7 1.438E-5 1.001E-4 2.286E-4 4 191
14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Normal fetal kidney MNP2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Normal fetal kidney MNP2 Adult, Development, and Cancer types 4.033E-7 1.438E-5 1.001E-4 2.384E-4 4 193
15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal fetal kidney IF-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal fetal kidney IF-U Adult, Development, and Cancer types 4.118E-7 1.438E-5 1.001E-4 2.433E-4 4 194
16 Human Cell Atlas Human Cell Atlas Immune Immune Overall Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Overall Top 200 Genes 4.203E-7 1.438E-5 1.001E-4 2.484E-4 4 195
17 10X Human 8K PBMC unknown Overall Top 200 Genes 10X Human 8K PBMC unknown Overall Top 200 Genes 4.290E-7 1.438E-5 1.001E-4 2.535E-4 4 196
18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC1/Kidney Normal fetal kidney MNP RCC1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC1/Kidney Normal fetal kidney MNP RCC1 Adult, Development, and Cancer types 4.378E-7 1.438E-5 1.001E-4 2.588E-4 4 197
19 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour RCC PT-U/Kidney Tumour RCC PT15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour RCC PT-U/Kidney Tumour RCC PT15 Adult, Development, and Cancer types 9.366E-7 2.913E-5 2.028E-4 5.535E-4 3 57
20 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour PapRCC PT-U/Kidney Tumour PapRCC PT15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour PapRCC PT-U/Kidney Tumour PapRCC PT15 Adult, Development, and Cancer types 1.151E-6 3.402E-5 2.368E-4 6.804E-4 3 61
21 Human Cell Atlas Human Cell Atlas B cell B cell Subtype Pro-B Top 200 Genes Human Cell Atlas Human Cell Atlas B cell B cell Subtype Pro-B Top 200 Genes 1.858E-6 5.230E-5 3.640E-4 1.098E-3 4 283
22 Human Cell Atlas Human Cell Atlas B cell B cell Subtype CD34+ pre-B cycling Top 200 Genes Human Cell Atlas Human Cell Atlas B cell B cell Subtype CD34+ pre-B cycling Top 200 Genes 2.470E-6 6.637E-5 4.619E-4 1.460E-3 4 304
23 Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ pre-T Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ pre-T Top 200 Genes 2.670E-6 6.660E-5 4.635E-4 1.578E-3 4 310
24 Human Cell Atlas Human Cell Atlas Megakaryocytic Megakaryocytic Subtype CD34+ MKP Top 200 Genes Human Cell Atlas Human Cell Atlas Megakaryocytic Megakaryocytic Subtype CD34+ MKP Top 200 Genes 2.704E-6 6.660E-5 4.635E-4 1.598E-3 4 311
25 Human Cell Atlas Human Cell Atlas HSC HSC Subtype CD34+ LMPP Top 200 Genes Human Cell Atlas Human Cell Atlas HSC HSC Subtype CD34+ LMPP Top 200 Genes 3.341E-6 7.594E-5 5.285E-4 1.974E-3 4 328
26 10X Human 8K PBMC unknown Subtype unknown-T cells CD8 - D CCL5 positive Top 200 Genes 10X Human 8K PBMC unknown Subtype unknown-T cells CD8 - D CCL5 positive Top 200 Genes 3.341E-6 7.594E-5 5.285E-4 1.974E-3 4 328
27 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U Adult, Development, and Cancer types 3.494E-6 7.648E-5 5.323E-4 2.065E-3 3 88
28 Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ CLP Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ CLP Top 200 Genes 3.764E-6 7.944E-5 5.529E-4 2.224E-3 4 338
29 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal fetal kidney PT-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal fetal kidney PT-U Adult, Development, and Cancer types 4.984E-6 1.016E-4 7.070E-4 2.946E-3 3 99
30 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal fetal kidney Normal cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal fetal kidney Normal cell Adult, Development, and Cancer types 5.782E-6 1.139E-4 7.928E-4 3.417E-3 3 104
31 10X Human 8K PBMC unknown Subtype unknown-unknown Top 200 Genes 10X Human 8K PBMC unknown Subtype unknown-unknown Top 200 Genes 6.177E-6 1.178E-4 8.196E-4 3.651E-3 4 383
32 10X Human 8K PBMC unknown Subtype unknown-T cell CD4 - B Top 200 Genes 10X Human 8K PBMC unknown Subtype unknown-T cell CD4 - B Top 200 Genes 6.772E-6 1.226E-4 8.532E-4 4.002E-3 4 392
33 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal fetal kidney EN-A Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal fetal kidney EN-A Adult, Development, and Cancer types 6.845E-6 1.226E-4 8.532E-4 4.046E-3 3 110
34 Human Cell Atlas Human Cell Atlas Megakaryocytic Megakaryocytic Top 200 Human Cell Atlas Human Cell Atlas Megakaryocytic Megakaryocytic Top 200 7.933E-6 1.379E-4 9.597E-4 4.688E-3 4 408
35 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal fetal kidney Nephron epithelium/Kidney Normal fetal kidney N1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal fetal kidney Nephron epithelium/Kidney Normal fetal kidney N1 Adult, Development, and Cancer types 1.323E-5 2.235E-4 1.555E-3 7.822E-3 3 137
36 Kidney10XCellRanger Six2KI P0 unknown unknown Overall Top 200 Genes Kidney10XCellRanger Six2KI P0 unknown unknown Overall Top 200 Genes 2.352E-5 3.577E-4 2.490E-3 1.390E-2 3 166
37 Kidney10XCellRanger Six2KI P0 unknown unknown Top 200 Kidney10XCellRanger Six2KI P0 unknown unknown Top 200 2.352E-5 3.577E-4 2.490E-3 1.390E-2 3 166
38 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex Wilms R U/Kidney Normal-Cortex Wilms R12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex Wilms R U/Kidney Normal-Cortex Wilms R12 Adult, Development, and Cancer types 2.995E-5 3.577E-4 2.490E-3 1.770E-2 3 180
39 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell/Kidney Normal fetal kidney NK1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell/Kidney Normal fetal kidney NK1 Adult, Development, and Cancer types 3.147E-5 3.577E-4 2.490E-3 1.860E-2 3 183
40 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal fetal kidney Normal cell/Kidney Normal fetal kidney T1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal fetal kidney Normal cell/Kidney Normal fetal kidney T1 Adult, Development, and Cancer types 3.147E-5 3.577E-4 2.490E-3 1.860E-2 3 183
41 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R-U/Kidney Normal fetal kidney R-U/Kidney Normal fetal kidney R1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R-U/Kidney Normal fetal kidney R-U/Kidney Normal fetal kidney R1 Adult, Development, and Cancer types 3.199E-5 3.577E-4 2.490E-3 1.890E-2 3 184
42 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP/Kidney Normal fetal kidney MNP Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP/Kidney Normal fetal kidney MNP Adult, Development, and Cancer types 3.251E-5 3.577E-4 2.490E-3 1.921E-2 3 185
43 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal VHL RCC R U/Kidney Normal VHL RCC R17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal VHL RCC R U/Kidney Normal VHL RCC R17 Adult, Development, and Cancer types 3.251E-5 3.577E-4 2.490E-3 1.921E-2 3 185
44 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NKT cell/Kidney Normal fetal kidney NKT cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NKT cell/Kidney Normal fetal kidney NKT cell Adult, Development, and Cancer types 3.303E-5 3.577E-4 2.490E-3 1.952E-2 3 186
45 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Wilms tumour/Kidney Normal fetal kidney Wilms tumour Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Wilms tumour/Kidney Normal fetal kidney Wilms tumour Adult, Development, and Cancer types 3.357E-5 3.577E-4 2.490E-3 1.984E-2 3 187
46 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal fetal kidney EN-A/Kidney Normal fetal kidney EN7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal fetal kidney EN-A/Kidney Normal fetal kidney EN7 Adult, Development, and Cancer types 3.357E-5 3.577E-4 2.490E-3 1.984E-2 3 187
47 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-C/Kidney Normal fetal kidney EN-C Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-C/Kidney Normal fetal kidney EN-C Adult, Development, and Cancer types 3.411E-5 3.577E-4 2.490E-3 2.016E-2 3 188
48 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U/Kidney Normal fetal kidney U-U/Kidney Normal fetal kidney U7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U/Kidney Normal fetal kidney U-U/Kidney Normal fetal kidney U7 Adult, Development, and Cancer types 3.411E-5 3.577E-4 2.490E-3 2.016E-2 3 188
49 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Normal fetal kidney Fetus other Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Normal fetal kidney Fetus other Adult, Development, and Cancer types 3.465E-5 3.577E-4 2.490E-3 2.048E-2 3 189
50 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal RCC NK cell/Kidney Normal RCC NK14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal RCC NK cell/Kidney Normal RCC NK14 Adult, Development, and Cancer types 3.465E-5 3.577E-4 2.490E-3 2.048E-2 3 189
Show 45 more annotations

15: Computational [Display Chart] 8 input genes in category / 154 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M7466 MODULE 32 Genes in the cancer module 32. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.847E-9 6.169E-7 3.466E-6 7.464E-7 6 241
2 M7191 MORF DEK Neighborhood of DEK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.012E-9 6.169E-7 3.466E-6 1.234E-6 6 262
3 M1046 MORF SMC1L1 Neighborhood of SMC1L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.070E-8 4.234E-6 2.378E-5 1.397E-5 4 62
4 M8084 MODULE 183 RNA splicing. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.100E-7 4.234E-6 2.378E-5 1.694E-5 4 65
5 M18997 MORF XRCC5 Neighborhood of XRCC5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.491E-7 1.075E-5 6.041E-5 5.377E-5 5 234
6 M18698 MORF EIF3S2 Neighborhood of EIF3S2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.301E-7 1.104E-5 6.201E-5 6.623E-5 5 244
7 M11080 MORF HDAC1 Neighborhood of HDAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.252E-7 1.156E-5 6.491E-5 8.089E-5 5 254
8 M13419 MORF BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.937E-7 1.528E-5 8.583E-5 1.222E-4 5 276
9 M18398 MORF GNB1 Neighborhood of GNB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.261E-6 2.158E-5 1.212E-4 1.942E-4 5 303
10 M16886 MORF PPP2CA Neighborhood of PPP2CA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.646E-6 2.534E-5 1.424E-4 2.534E-4 4 127
11 M7309 MORF RAD23A Neighborhood of RAD23A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.397E-6 3.356E-5 1.885E-4 3.692E-4 5 345
12 M3665 MORF CDC10 Neighborhood of CDC10 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.646E-6 3.395E-5 1.907E-4 4.075E-4 4 143
13 M1339 GNF2 FBL Neighborhood of FBL MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.954E-6 3.500E-5 1.966E-4 4.549E-4 4 147
14 M7638 GCM RAF1 Neighborhood of RAF1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.041E-6 4.445E-5 2.497E-4 6.223E-4 3 43
15 M446 MORF HAT1 Neighborhood of HAT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.786E-6 5.940E-5 3.337E-4 8.910E-4 4 174
16 M13609 MORF PRKDC Neighborhood of PRKDC MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.208E-6 7.900E-5 4.438E-4 1.264E-3 4 190
17 M15222 MORF AATF Neighborhood of AATF MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.110E-5 1.002E-4 5.626E-4 1.709E-3 4 205
18 M10414 MORF ESPL1 Neighborhood of ESPL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.171E-5 1.002E-4 5.626E-4 1.803E-3 3 61
19 M1646 GCM DDX5 Neighborhood of DDX5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.419E-5 1.150E-4 6.459E-4 2.185E-3 3 65
20 M11176 MORF CDK2 Neighborhood of CDK2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.852E-5 1.402E-4 7.874E-4 2.852E-3 3 71
21 M9226 GNF2 NPM1 Neighborhood of NPM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.932E-5 1.402E-4 7.874E-4 2.975E-3 3 72
22 M10939 MORF UBE2I Neighborhood of UBE2I MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.002E-5 1.402E-4 7.874E-4 3.084E-3 4 238
23 M11406 MORF HDAC2 Neighborhood of HDAC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.641E-5 2.438E-4 1.369E-3 5.607E-3 4 277
24 M8078 GNF2 APEX1 Neighborhood of APEX1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.037E-5 2.591E-4 1.455E-3 6.217E-3 3 92
25 M1109 MORF UBE2N Neighborhood of UBE2N MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.306E-5 2.653E-4 1.490E-3 6.632E-3 3 94
26 M1104 MORF RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.499E-5 3.257E-4 1.830E-3 8.469E-3 3 102
27 M1232 MORF RAF1 Neighborhood of RAF1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.892E-5 3.931E-4 2.208E-3 1.061E-2 3 110
28 M10146 MORF DNMT1 Neighborhood of DNMT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.285E-5 4.557E-4 2.560E-3 1.276E-2 3 117
29 M6545 MORF FBL Neighborhood of FBL MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.383E-4 7.339E-4 4.123E-3 2.130E-2 3 139
30 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.430E-4 7.339E-4 4.123E-3 2.202E-2 4 393
31 M13545 MORF RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.734E-4 8.615E-4 4.839E-3 2.671E-2 3 150
32 M19951 GNF2 BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.080E-4 9.706E-4 5.452E-3 3.203E-2 2 28
33 M10646 GCM MSN Neighborhood of MSN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.080E-4 9.706E-4 5.452E-3 3.203E-2 2 28
34 M12947 MORF CTBP1 Neighborhood of CTBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.425E-4 1.098E-3 6.170E-3 3.735E-2 3 168
35 M11132 MORF RAD21 Neighborhood of RAD21 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.071E-4 1.351E-3 7.591E-3 4.730E-2 3 182
36 M14651 GNF2 TDG Neighborhood of TDG MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.265E-4 1.397E-3 7.845E-3
5.027E-2
 2 35
37 M14741 GCM ANP32B Neighborhood of ANP32B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.455E-4 1.435E-3 8.060E-3
5.321E-2
 2 36
38 M7462 MORF RPA2 Neighborhood of RPA2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.541E-4 1.435E-3 8.060E-3
5.453E-2
 3 191
39 M6058 MORF DAP3 Neighborhood of DAP3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.651E-4 1.442E-3 8.098E-3
5.622E-2
 3 193
40 M3292 GCM HDAC1 Neighborhood of HDAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.853E-4 1.457E-3 8.182E-3
5.933E-2
 2 38
41 M19884 MORF ANP32B Neighborhood of ANP32B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.878E-4 1.457E-3 8.182E-3
5.972E-2
 3 197
42 M2705 MORF ACP1 Neighborhood of ACP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.679E-4 1.699E-3 9.545E-3
7.205E-2
 3 210
43 M5796 MORF RAC1 Neighborhood of RAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.745E-4 1.699E-3 9.545E-3
7.307E-2
 3 211
44 M18404 GCM PFN1 Neighborhood of PFN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.951E-4 2.396E-3 1.346E-2
1.070E-1
 2 51
45 M5047 MORF DDB1 Neighborhood of DDB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.002E-4 2.396E-3 1.346E-2
1.078E-1
 3 241
46 M15612 GNF2 DEK Neighborhood of DEK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.987E-4 3.009E-3 1.690E-2
1.384E-1
 2 58
47 M17615 MORF RAN Neighborhood of RAN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.543E-4 3.123E-3 1.754E-2
1.470E-1
 3 268
48 M17234 MORF MSH2 Neighborhood of MSH2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.937E-4 3.123E-3 1.754E-2
1.530E-1
 2 61
49 M17665 MORF RPA1 Neighborhood of RPA1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.937E-4 3.123E-3 1.754E-2
1.530E-1
 2 61
50 M7895 MORF SOD1 Neighborhood of SOD1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.051E-3 3.236E-3 1.818E-2
1.618E-1
 3 277
Show 45 more annotations

16: MicroRNA [Display Chart] 8 input genes in category / 683 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-606:PITA hsa-miR-606:PITA TOP PITA 3.949E-6 1.407E-3 9.993E-3 2.697E-3 3 301
2 hsa-miR-410:PITA hsa-miR-410:PITA TOP PITA 6.973E-6 1.407E-3 9.993E-3 4.763E-3 3 364
3 hsa-miR-221-3p:Functional MTI Functional MTI miRTarbase 7.205E-6 1.407E-3 9.993E-3 4.921E-3 3 368
4 hsa-miR-197-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.878E-6 1.407E-3 9.993E-3 6.747E-3 3 409
5 hsa-miR-365*:mirSVR highEffct hsa-miR-365*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.358E-5 1.407E-3 9.993E-3 9.273E-3 3 455
6 hsa-miR-4641:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.419E-5 1.407E-3 9.993E-3 9.691E-3 2 52
7 hsa-miR-140-3p.1:TargetScan hsa-miR-140-3p.1 TargetScan 1.593E-5 1.407E-3 9.993E-3 1.088E-2 3 480
8 hsa-miR-555:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.648E-5 1.407E-3 9.993E-3 1.125E-2 2 56
9 hsa-miR-3156-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.156E-5 1.636E-3 1.162E-2 1.472E-2 2 64
10 hsa-miR-4539:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.809E-5 1.919E-3 1.363E-2 1.919E-2 2 73
11 hsa-miR-299-3p:TargetScan hsa-miR-299-3p TargetScan 4.667E-5 2.366E-3 1.681E-2 3.187E-2 2 94
12 hsa-miR-4724-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.073E-5 2.366E-3 1.681E-2 3.465E-2 2 98
13 hsa-miR-6877-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.236E-5 2.366E-3 1.681E-2 4.942E-2 2 117
14 hsa-miR-548o-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.360E-5 2.366E-3 1.681E-2
5.027E-2
 2 118
15 hsa-miR-183-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.360E-5 2.366E-3 1.681E-2
5.027E-2
 2 118
16 hsa-miR-154-5p:TargetScan hsa-miR-154-5p TargetScan 7.360E-5 2.366E-3 1.681E-2
5.027E-2
 2 118
17 hsa-miR-6819-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.485E-5 2.366E-3 1.681E-2
5.112E-2
 2 119
18 hsa-miR-1323:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.612E-5 2.366E-3 1.681E-2
5.199E-2
 2 120
19 hsa-miR-519b-5p:PITA hsa-miR-519b-5p:PITA TOP PITA 7.997E-5 2.366E-3 1.681E-2
5.462E-2
 2 123
20 hsa-miR-519c-5p:PITA hsa-miR-519c-5p:PITA TOP PITA 7.997E-5 2.366E-3 1.681E-2
5.462E-2
 2 123
21 hsa-miR-518d-5p:PITA hsa-miR-518d-5p:PITA TOP PITA 7.997E-5 2.366E-3 1.681E-2
5.462E-2
 2 123
22 hsa-miR-520c-5p:PITA hsa-miR-520c-5p:PITA TOP PITA 7.997E-5 2.366E-3 1.681E-2
5.462E-2
 2 123
23 hsa-miR-526a:PITA hsa-miR-526a:PITA TOP PITA 7.997E-5 2.366E-3 1.681E-2
5.462E-2
 2 123
24 hsa-miR-493-3p:TargetScan hsa-miR-493-3p TargetScan 8.393E-5 2.366E-3 1.681E-2
5.732E-2
 2 126
25 hsa-miR-552-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.934E-5 2.366E-3 1.681E-2
6.102E-2
 2 130
26 hsa-miR-625:PITA hsa-miR-625:PITA TOP PITA 9.072E-5 2.366E-3 1.681E-2
6.196E-2
 2 131
27 hsa-miR-1275:PITA hsa-miR-1275:PITA TOP PITA 9.351E-5 2.366E-3 1.681E-2
6.387E-2
 2 133
28 hsa-miR-141-3p:Functional MTI Functional MTI miRTarbase 1.111E-4 2.586E-3 1.837E-2
7.591E-2
 2 145
29 hsa-miR-8054:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.174E-4 2.586E-3 1.837E-2
8.015E-2
 2 149
30 hsa-miR-548av-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.174E-4 2.586E-3 1.837E-2
8.015E-2
 2 149
31 hsa-miR-548k:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.174E-4 2.586E-3 1.837E-2
8.015E-2
 2 149
32 hsa-miR-208b-3p:TargetScan hsa-miR-208b-3p TargetScan 1.387E-4 2.796E-3 1.987E-2
9.473E-2
 2 162
33 hsa-miR-208a-3p:TargetScan hsa-miR-208a-3p TargetScan 1.387E-4 2.796E-3 1.987E-2
9.473E-2
 2 162
34 hsa-miR-188-5p:TargetScan hsa-miR-188-5p TargetScan 1.404E-4 2.796E-3 1.987E-2
9.591E-2
 2 163
35 hsa-miR-190b:TargetScan hsa-miR-190b TargetScan 1.474E-4 2.796E-3 1.987E-2
1.007E-1
 2 167
36 hsa-miR-190a-5p:TargetScan hsa-miR-190a-5p TargetScan 1.474E-4 2.796E-3 1.987E-2
1.007E-1
 2 167
37 hsa-miR-1197:TargetScan hsa-miR-1197 TargetScan 1.545E-4 2.852E-3 2.026E-2
1.055E-1
 2 171
38 hsa-miR-455-5p:TargetScan hsa-miR-455-5p TargetScan 1.827E-4 3.235E-3 2.298E-2
1.248E-1
 2 186
39 hsa-miR-335:PITA hsa-miR-335:PITA TOP PITA 1.847E-4 3.235E-3 2.298E-2
1.262E-1
 2 187
40 hsa-miR-188-5p:PITA hsa-miR-188-5p:PITA TOP PITA 1.967E-4 3.299E-3 2.344E-2
1.344E-1
 2 193
41 hsa-let-7d*:mirSVR highEffct hsa-let-7d*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.008E-4 3.299E-3 2.344E-2
1.372E-1
 2 195
42 hsa-miR-154:PITA hsa-miR-154:PITA TOP PITA 2.029E-4 3.299E-3 2.344E-2
1.386E-1
 2 196
43 ATATGCA,MIR-448:MSigDB ATATGCA,MIR-448:MSigDB MSigDB 2.176E-4 3.444E-3 2.447E-2
1.486E-1
 2 203
44 hsa-miR-202-5p:TargetScan hsa-miR-202-5p TargetScan 2.219E-4 3.444E-3 2.447E-2
1.515E-1
 2 205
45 hsa-miR-767-3p:PITA hsa-miR-767-3p:PITA TOP PITA 2.417E-4 3.622E-3 2.573E-2
1.651E-1
 2 214
46 hsa-miR-335-5p:TargetScan hsa-miR-335-5p TargetScan 2.440E-4 3.622E-3 2.573E-2
1.666E-1
 2 215
47 hsa-miR-499-5p:PITA hsa-miR-499-5p:PITA TOP PITA 2.647E-4 3.847E-3 2.733E-2
1.808E-1
 2 224
48 ATGTTAA,MIR-302C:MSigDB ATGTTAA,MIR-302C:MSigDB MSigDB 2.839E-4 4.040E-3 2.870E-2
1.939E-1
 2 232
49 hsa-miR-505:PITA hsa-miR-505:PITA TOP PITA 3.088E-4 4.258E-3 3.025E-2
2.109E-1
 2 242
50 hsa-miR-433:PITA hsa-miR-433:PITA TOP PITA 3.165E-4 4.258E-3 3.025E-2
2.161E-1
 2 245
Show 45 more annotations

17: Drug [Display Chart] 8 input genes in category / 914 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000001160 AC1L1AUZ Stitch 2.652E-12 2.265E-9 1.675E-8 2.424E-9 6 157
2 CID005287709 AC1NRA5C Stitch 4.956E-12 2.265E-9 1.675E-8 4.530E-9 6 174
3 CID000001287 AC1L1B55 Stitch 1.616E-9 4.922E-7 3.640E-6 1.477E-6 6 454
4 ctd:C080703 SK&F 83959 CTD 1.362E-7 3.113E-5 2.302E-4 1.245E-4 4 154
5 ctd:C515564 bromovanin CTD 9.211E-6 1.684E-3 1.245E-2 8.419E-3 3 127
6 ctd:D015647 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine CTD 1.946E-5 2.934E-3 2.170E-2 1.779E-2 3 163
7 ctd:C540575 MK2i peptide CTD 2.247E-5 2.934E-3 2.170E-2 2.054E-2 2 21
8 ctd:C037219 quinoline CTD 2.417E-4 2.001E-2
1.480E-1
2.209E-1
 2 68
9 CID005287474 2-phenylheme Stitch 3.502E-4 2.001E-2
1.480E-1
3.201E-1
 1 1
10 ctd:C474696 methyl-(4-carboxyphenyl)glycine CTD 3.502E-4 2.001E-2
1.480E-1
3.201E-1
 1 1
11 ctd:C011369 threonic acid CTD 3.502E-4 2.001E-2
1.480E-1
3.201E-1
 1 1
12 ctd:D002191 Canrenoic Acid CTD 3.502E-4 2.001E-2
1.480E-1
3.201E-1
 1 1
13 CID003015783 5-Amino-2,4,6-triiodoisophthalic acid Stitch 3.502E-4 2.001E-2
1.480E-1
3.201E-1
 1 1
14 ctd:D006603 Hexuronic Acids CTD 3.502E-4 2.001E-2
1.480E-1
3.201E-1
 1 1
15 ctd:C019249 aminomalonic acid CTD 3.502E-4 2.001E-2
1.480E-1
3.201E-1
 1 1
16 ctd:C003460 threitol CTD 3.502E-4 2.001E-2
1.480E-1
3.201E-1
 1 1
17 ctd:C039060 dihydroartemisinin CTD 5.223E-4 2.808E-2
2.077E-1
4.774E-1
 2 100
18 CID000439502 poly(G Stitch 6.780E-4 3.369E-2
2.492E-1
6.197E-1
 2 114
19 CID000101153 Pinol Stitch 7.004E-4 3.369E-2
2.492E-1
6.402E-1
 1 2
20 CID000082127 potassium hydride Stitch 8.534E-4 3.427E-2
2.535E-1
7.800E-1
 2 128
21 CID006914639 AC1OCADI Stitch 8.801E-4 3.427E-2
2.535E-1
8.044E-1
 2 130
22 ctd:C075773 4-phenylbutyric acid CTD 1.184E-3 3.427E-2
2.535E-1
1.000E0
 2 151
23 CID006439630 PS-8 Stitch 1.400E-3 3.427E-2
2.535E-1
1.000E0
 1 4
24 CID010026604 SureCN5629434 Stitch 1.400E-3 3.427E-2
2.535E-1
1.000E0
 1 4
25 2145 DN Emetine dihydrochloride [316-42-7]; Down 200; 7.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.411E-3 3.427E-2
2.535E-1
1.000E0
 2 165
26 CID000000314 polycytidylic acid Stitch 1.480E-3 3.427E-2
2.535E-1
1.000E0
 2 169
27 4827 DN Emetine dihydrochloride [316-42-7]; Down 200; 7.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.621E-3 3.427E-2
2.535E-1
1.000E0
 2 177
28 ctd:D002084 Butylated Hydroxytoluene CTD 1.658E-3 3.427E-2
2.535E-1
1.000E0
 2 179
29 1764 DN Piperlongumine [20069-09-4]; Down 200; 12.6uM; HL60; HG-U133A Broad Institute CMAP Down 1.658E-3 3.427E-2
2.535E-1
1.000E0
 2 179
30 5530 DN Parthenolide [20554-84-1]; Down 200; 16.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.732E-3 3.427E-2
2.535E-1
1.000E0
 2 183
31 ctd:D065108 Ornithine Decarboxylase Inhibitors CTD 1.750E-3 3.427E-2
2.535E-1
1.000E0
 1 5
32 ctd:C506425 eurycomanone CTD 1.750E-3 3.427E-2
2.535E-1
1.000E0
 1 5
33 CID005357915 AC1NSBNC Stitch 1.750E-3 3.427E-2
2.535E-1
1.000E0
 1 5
34 1563 DN Quinacrine dihydrochloride dihydrate [6151-30-0]; Down 200; 7.8uM; HL60; HG-U133A Broad Institute CMAP Down 1.788E-3 3.427E-2
2.535E-1
1.000E0
 2 186
35 1769 DN Ipratropium bromide [22254-24-6]; Down 200; 9.8uM; HL60; HG-U133A Broad Institute CMAP Down 1.846E-3 3.427E-2
2.535E-1
1.000E0
 2 189
36 614 UP monastrol; Up 200; 20uM; MCF7; HG-U133A Broad Institute CMAP Up 1.884E-3 3.427E-2
2.535E-1
1.000E0
 2 191
37 1418 DN Pargyline hydrochloride [306-07-0]; Down 200; 20.4uM; HL60; HG-U133A Broad Institute CMAP Down 1.884E-3 3.427E-2
2.535E-1
1.000E0
 2 191
38 1982 DN Hexamethonium dibromide dihydrate [55-97-0]; Down 200; 10uM; HL60; HG-U133A Broad Institute CMAP Down 1.923E-3 3.427E-2
2.535E-1
1.000E0
 2 193
39 1724 DN Imipenem [74431-23-5]; Down 200; 13.4uM; HL60; HG-U133A Broad Institute CMAP Down 1.943E-3 3.427E-2
2.535E-1
1.000E0
 2 194
40 1741 DN Laudanosine (R,S) [1699-51-0]; Down 200; 11.2uM; HL60; HG-U133A Broad Institute CMAP Down 1.943E-3 3.427E-2
2.535E-1
1.000E0
 2 194
41 2021 DN Cyproheptadine hydrochloride [969-33-5]; Down 200; 12.4uM; HL60; HG-U133A Broad Institute CMAP Down 1.983E-3 3.427E-2
2.535E-1
1.000E0
 2 196
42 1978 UP Prednisone [53-03-2]; Up 200; 11.2uM; HL60; HG-U133A Broad Institute CMAP Up 1.983E-3 3.427E-2
2.535E-1
1.000E0
 2 196
43 2005 DN Apomorphine hydrochloride hemihydrate [41372-20-7]; Down 200; 6.4uM; HL60; HG-U133A Broad Institute CMAP Down 1.983E-3 3.427E-2
2.535E-1
1.000E0
 2 196
44 6240 DN Terbutaline hemisulfate [23031-32-5]; Down 200; 7.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.003E-3 3.427E-2
2.535E-1
1.000E0
 2 197
45 164 DN R(+)-verapamil hydrochloride; Down 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Down 2.003E-3 3.427E-2
2.535E-1
1.000E0
 2 197
46 1777 DN Acetopromazine maleate salt [3598-37-6]; Down 200; 9uM; HL60; HG-U133A Broad Institute CMAP Down 2.003E-3 3.427E-2
2.535E-1
1.000E0
 2 197
47 335 DN nifedipine; Down 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Down 2.003E-3 3.427E-2
2.535E-1
1.000E0
 2 197
48 7264 UP Clorsulon [60200-06-8]; Up 200; 10.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.003E-3 3.427E-2
2.535E-1
1.000E0
 2 197
49 594 UP arachidonyl trifluoromethyl ketone; Up 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Up 2.023E-3 3.427E-2
2.535E-1
1.000E0
 2 198
50 1824 DN Atracurium besylate [64228-81-5]; Down 200; 3.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.023E-3 3.427E-2
2.535E-1
1.000E0
 2 198
Show 45 more annotations

18: Disease [Display Chart] 8 input genes in category / 289 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0026272 Mixed Connective Tissue Disease DisGeNET BeFree 3.250E-5 7.509E-3 4.690E-2 9.393E-3 2 18
2 C1839785 Folate-dependent fragile site at Xq28 DisGeNET Curated 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
3 C4022575 Inertia DisGeNET Curated 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
4 cv:C1839780 Fragile X tremor/ataxia syndrome Clinical Variations 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
5 C3275521 CHROMOSOME Xq27.3-q28 DUPLICATION SYNDROME DisGeNET Curated 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
6 C0476236 Developmental symptoms DisGeNET BeFree 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
7 C3494522 Hypergonadotropic Ovarian Failure, X-Linked DisGeNET BeFree 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
8 C0748071 psychosocial impairment DisGeNET BeFree 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
9 C4024650 Congenital macroorchidism DisGeNET Curated 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
10 cv:C2749126 Premature ovarian failure 1 Clinical Variations 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
11 C3264595 Agoraphobia without panic disorder DisGeNET BeFree 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
12 cv:CN180154 Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2 Clinical Variations 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
13 OMIN:300624 FRAGILE X MENTAL RETARDATION SYNDROME OMIM 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
14 C0476217 Head movements abnormal DisGeNET Curated 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
15 cv:C0016667 Fragile X syndrome Clinical Variations 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
16 C2749127 Primary Ovarian Insufficiency, Fragile X-Associated DisGeNET Curated 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
17 OMIN:311360 PREMATURE OVARIAN FAILURE 1; POF1 OMIM 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
18 C0679378 neurodevelopmental anomaly DisGeNET BeFree 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
19 OMIN:300623 FRAGILE X TREMOR/ATAXIA SYNDROME; FXTAS OMIM 4.937E-4 7.509E-3 4.690E-2
1.427E-1
 1 1
20 C0014378 Enterovirus Infections DisGeNET Curated 9.112E-4 1.097E-2
6.853E-2
2.633E-1
 2 94
21 C1854699 Diffuse cerebellar atrophy DisGeNET Curated 9.871E-4 1.097E-2
6.853E-2
2.853E-1
 1 2
22 C0042023 Increased frequency of micturition DisGeNET Curated 9.871E-4 1.097E-2
6.853E-2
2.853E-1
 1 2
23 C2678248 Mood instability DisGeNET Curated 9.871E-4 1.097E-2
6.853E-2
2.853E-1
 1 2
24 C1839782 Macroorchidism, postpubertal DisGeNET Curated 9.871E-4 1.097E-2
6.853E-2
2.853E-1
 1 2
25 C0236801 Phobia, Specific DisGeNET Curated 9.871E-4 1.097E-2
6.853E-2
2.853E-1
 1 2
26 C3809468 INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA 2 DisGeNET Curated 9.871E-4 1.097E-2
6.853E-2
2.853E-1
 1 2
27 C0333751 Muscle fiber atrophy DisGeNET Curated 1.480E-3 1.258E-2
7.859E-2
4.278E-1
 1 3
28 C0742035 Cerebellar lesions DisGeNET BeFree 1.480E-3 1.258E-2
7.859E-2
4.278E-1
 1 3
29 C3825158 Learning disabled DisGeNET BeFree 1.480E-3 1.258E-2
7.859E-2
4.278E-1
 1 3
30 C0596131 audiogenic seizure DisGeNET BeFree 1.480E-3 1.258E-2
7.859E-2
4.278E-1
 1 3
31 C4280583 Hypertrophy of forehead DisGeNET Curated 1.480E-3 1.258E-2
7.859E-2
4.278E-1
 1 3
32 C1839783 Large forehead DisGeNET Curated 1.480E-3 1.258E-2
7.859E-2
4.278E-1
 1 3
33 C1836479 Saccadic smooth pursuit DisGeNET Curated 1.480E-3 1.258E-2
7.859E-2
4.278E-1
 1 3
34 C4280584 Hyperplasia of forehead DisGeNET Curated 1.480E-3 1.258E-2
7.859E-2
4.278E-1
 1 3
35 C1867864 Poor fine motor coordination DisGeNET Curated 1.973E-3 1.501E-2
9.373E-2
5.703E-1
 1 4
36 C1853767 Decreased distal vibration sense DisGeNET Curated 1.973E-3 1.501E-2
9.373E-2
5.703E-1
 1 4
37 C0393524 Cerebellar Ataxia, Late Onset DisGeNET BeFree 1.973E-3 1.501E-2
9.373E-2
5.703E-1
 1 4
38 C1834433 Obsessive-compulsive trait DisGeNET Curated 1.973E-3 1.501E-2
9.373E-2
5.703E-1
 1 4
39 C0338451 Frontotemporal dementia DisGeNET Curated 2.034E-3 1.507E-2
9.413E-2
5.878E-1
 2 141
40 C0751156 FRAXA Syndrome DisGeNET Curated 2.466E-3 1.738E-2
1.086E-1
7.127E-1
 1 5
41 C1864172 Peroxisome Biogenesis Disorder, Complementation Group G DisGeNET BeFree 2.466E-3 1.738E-2
1.086E-1
7.127E-1
 1 5
42 C0156404 Irregular periods DisGeNET Curated 2.959E-3 2.036E-2
1.272E-1
8.551E-1
 1 6
43 C0015732 Fecal Incontinence DisGeNET Curated 3.451E-3 2.252E-2
1.406E-1
9.974E-1
 1 7
44 C0432482 Fragile X chromosome DisGeNET BeFree 3.451E-3 2.252E-2
1.406E-1
9.974E-1
 1 7
45 C0026850 Muscular Dystrophy DisGeNET Curated 3.506E-3 2.252E-2
1.406E-1
1.000E0
 2 186
46 C0282631 Facies DisGeNET Curated 3.943E-3 2.326E-2
1.453E-1
1.000E0
 1 8
47 C1263023 Macroorchidism DisGeNET Curated 3.943E-3 2.326E-2
1.453E-1
1.000E0
 1 8
48 C0598275 Diffuse cerebral atrophy DisGeNET Curated 3.943E-3 2.326E-2
1.453E-1
1.000E0
 1 8
49 C1849173 Periventricular neuronal heterotopia DisGeNET Curated 3.943E-3 2.326E-2
1.453E-1
1.000E0
 1 8
50 C0687131 Psychoticism DisGeNET BeFree 4.435E-3 2.513E-2
1.570E-1
1.000E0
 1 9
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