Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc291_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 9 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0017160 Ral GTPase binding 2.639E-9 2.375E-8 6.719E-8 2.375E-8 3 13
2 GO:0017016 Ras GTPase binding 3.304E-5 1.169E-4 3.306E-4 2.973E-4 3 281
3 GO:0031267 small GTPase binding 4.057E-5 1.169E-4 3.306E-4 3.651E-4 3 301
4 GO:0051020 GTPase binding 5.194E-5 1.169E-4 3.306E-4 4.675E-4 3 327
5 GO:0047485 protein N-terminus binding 3.850E-4 6.930E-4 1.960E-3 3.465E-3 2 117
6 GO:0030165 PDZ domain binding 3.018E-2 4.527E-2
1.281E-1
2.716E-1
 1 114
7 GO:0000149 SNARE binding 3.540E-2 4.551E-2
1.287E-1
3.186E-1
 1 134
Show 2 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 53 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006887 exocytosis 7.037E-9 3.730E-7 1.700E-6 3.730E-7 5 438
2 GO:0048278 vesicle docking 3.165E-7 8.387E-6 3.822E-5 1.677E-5 3 60
3 GO:0022406 membrane docking 5.746E-7 1.015E-5 4.626E-5 3.045E-5 3 73
4 GO:0051601 exocyst localization 3.169E-6 4.199E-5 1.913E-4 1.679E-4 2 11
5 GO:0016241 regulation of macroautophagy 5.918E-6 6.273E-5 2.859E-4 3.136E-4 3 158
6 GO:0032104 regulation of response to extracellular stimulus 9.352E-6 7.081E-5 3.227E-4 4.957E-4 3 184
7 GO:0032107 regulation of response to nutrient levels 9.352E-6 7.081E-5 3.227E-4 4.957E-4 3 184
8 GO:0034629 cellular protein-containing complex localization 2.335E-5 1.547E-4 7.048E-4 1.237E-3 2 29
9 GO:0010506 regulation of autophagy 2.758E-5 1.624E-4 7.401E-4 1.462E-3 3 264
10 GO:0006904 vesicle docking involved in exocytosis 4.480E-5 2.374E-4 1.082E-3 2.374E-3 2 40
11 GO:0016236 macroautophagy 1.109E-4 5.343E-4 2.435E-3 5.878E-3 3 421
12 GO:0031503 protein-containing complex localization 3.998E-4 1.766E-3 8.047E-3 2.119E-2 2 119
13 GO:0055108 Golgi to transport vesicle transport 5.369E-4 2.189E-3 9.975E-3 2.846E-2 1 2
14 GO:0001927 exocyst assembly 1.074E-3 4.064E-3 1.852E-2
5.690E-2
 1 4
15 GO:0035635 entry of bacterium into host cell 1.342E-3 4.445E-3 2.025E-2
7.112E-2
 1 5
16 GO:2000535 regulation of entry of bacterium into host cell 1.342E-3 4.445E-3 2.025E-2
7.112E-2
 1 5
17 GO:0048341 paraxial mesoderm formation 2.414E-3 7.527E-3 3.430E-2
1.280E-1
 1 9
18 GO:0048193 Golgi vesicle transport 3.205E-3 9.436E-3 4.300E-2
1.698E-1
 2 340
19 GO:0048340 paraxial mesoderm morphogenesis 3.486E-3 9.724E-3 4.431E-2
1.847E-1
 1 13
20 GO:0048339 paraxial mesoderm development 5.893E-3 1.562E-2
7.117E-2
3.123E-1
 1 22
21 GO:0044091 membrane biogenesis 8.563E-3 2.161E-2
9.848E-2
4.538E-1
 1 32
22 GO:0050850 positive regulation of calcium-mediated signaling 1.229E-2 2.893E-2
1.319E-1
6.514E-1
 1 46
23 GO:0072132 mesenchyme morphogenesis 1.256E-2 2.893E-2
1.319E-1
6.655E-1
 1 47
24 GO:0007032 endosome organization 1.760E-2 3.886E-2
1.771E-1
9.326E-1
 1 66
25 GO:0001707 mesoderm formation 1.945E-2 4.123E-2
1.879E-1
1.000E0
 1 73
26 GO:0048332 mesoderm morphogenesis 2.051E-2 4.180E-2
1.905E-1
1.000E0
 1 77
27 GO:0050848 regulation of calcium-mediated signaling 2.262E-2 4.439E-2
2.023E-1
1.000E0
 1 85
28 GO:0022617 extracellular matrix disassembly 2.446E-2 4.461E-2
2.033E-1
1.000E0
 1 92
29 GO:0048709 oligodendrocyte differentiation 2.499E-2 4.461E-2
2.033E-1
1.000E0
 1 94
30 GO:0006892 post-Golgi vesicle-mediated transport 2.525E-2 4.461E-2
2.033E-1
1.000E0
 1 95
31 GO:0030010 establishment of cell polarity 3.181E-2 4.546E-2
2.072E-1
1.000E0
 1 120
32 GO:0052126 movement in host environment 3.259E-2 4.546E-2
2.072E-1
1.000E0
 1 123
33 GO:0051828 entry into other organism involved in symbiotic interaction 3.259E-2 4.546E-2
2.072E-1
1.000E0
 1 123
34 GO:0001704 formation of primary germ layer 3.259E-2 4.546E-2
2.072E-1
1.000E0
 1 123
35 GO:0052192 movement in environment of other organism involved in symbiotic interaction 3.259E-2 4.546E-2
2.072E-1
1.000E0
 1 123
36 GO:0051806 entry into cell of other organism involved in symbiotic interaction 3.259E-2 4.546E-2
2.072E-1
1.000E0
 1 123
37 GO:0030260 entry into host cell 3.259E-2 4.546E-2
2.072E-1
1.000E0
 1 123
38 GO:0044409 entry into host 3.259E-2 4.546E-2
2.072E-1
1.000E0
 1 123
39 GO:0007498 mesoderm development 3.677E-2 4.997E-2
2.277E-1
1.000E0
 1 139
Show 34 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 21 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000145 exocyst 2.781E-12 5.840E-11 2.129E-10 5.840E-11 4 18
2 GO:0044448 cell cortex part 1.308E-8 1.373E-7 5.006E-7 2.746E-7 4 138
3 GO:0005938 cell cortex 1.834E-7 1.284E-6 4.680E-6 3.851E-6 4 266
4 GO:0099568 cytoplasmic region 4.094E-7 2.149E-6 7.835E-6 8.597E-6 4 325
5 GO:0032584 growth cone membrane 1.540E-6 6.470E-6 2.358E-5 3.235E-5 2 8
6 GO:0030426 growth cone 8.443E-6 2.748E-5 1.002E-4 1.773E-4 3 182
7 GO:0030427 site of polarized growth 9.159E-6 2.748E-5 1.002E-4 1.923E-4 3 187
8 GO:0035748 myelin sheath abaxonal region 2.359E-3 6.192E-3 2.257E-2 4.954E-2 1 9
9 GO:0034451 centriolar satellite 6.541E-3 1.526E-2
5.564E-2
1.374E-1
 1 25
10 GO:0043198 dendritic shaft 1.564E-2 3.285E-2
1.197E-1
3.285E-1
 1 60
11 GO:0005902 microvillus 2.313E-2 4.048E-2
1.476E-1
4.858E-1
 1 89
12 GO:0030667 secretory granule membrane 2.313E-2 4.048E-2
1.476E-1
4.858E-1
 1 89
Show 7 more annotations

4: Human Phenotype [Display Chart] 0 input genes in category / 0 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 4 input genes in category / 35 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0011491 ureteropelvic junction obstruction 1.544E-3 1.350E-2
5.599E-2
5.406E-2
 1 4
2 MP:0012105 delayed gastrulation 1.544E-3 1.350E-2
5.599E-2
5.406E-2
 1 4
3 MP:0011484 abnormal ureter urothelium morphology 1.544E-3 1.350E-2
5.599E-2
5.406E-2
 1 4
4 MP:0012142 absent amniotic cavity 1.544E-3 1.350E-2
5.599E-2
5.406E-2
 1 4
5 MP:0011487 abnormal ureteropelvic junction morphology 2.316E-3 1.350E-2
5.599E-2
8.106E-2
 1 6
6 MP:0012131 small visceral yolk sac 2.702E-3 1.350E-2
5.599E-2
9.456E-2
 1 7
7 MP:0012183 decreased paraxial mesoderm size 3.473E-3 1.350E-2
5.599E-2
1.215E-1
 1 9
8 MP:0003624 anuria 3.473E-3 1.350E-2
5.599E-2
1.215E-1
 1 9
9 MP:0003589 abnormal ureter physiology 3.858E-3 1.350E-2
5.599E-2
1.350E-1
 1 10
10 MP:0003587 ureter obstruction 3.858E-3 1.350E-2
5.599E-2
1.350E-1
 1 10
11 MP:0011426 abnormal ureter smooth muscle morphology 4.628E-3 1.473E-2
6.106E-2
1.620E-1
 1 12
12 MP:0011199 abnormal amniotic cavity morphology 7.704E-3 2.247E-2
9.318E-2
2.697E-1
 1 20
13 MP:0003630 abnormal urothelium morphology 1.269E-2 3.416E-2
1.417E-1
4.441E-1
 1 33
14 MP:0008029 abnormal paraxial mesoderm morphology 1.765E-2 4.413E-2
1.830E-1
6.179E-1
 1 46
Show 9 more annotations

6: Domain [Display Chart] 5 input genes in category / 21 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR016159 Cullin repeat-like dom InterPro 3.757E-6 7.889E-5 2.876E-4 7.889E-5 2 12
2 PF07393 Sec10 Pfam 2.669E-4 5.095E-4 1.857E-3 5.604E-3 1 1
3 IPR033960 EXOC5/Sec10 InterPro 2.669E-4 5.095E-4 1.857E-3 5.604E-3 1 1
4 IPR033961 Exo84 InterPro 2.669E-4 5.095E-4 1.857E-3 5.604E-3 1 1
5 IPR009976 Sec10-like InterPro 2.669E-4 5.095E-4 1.857E-3 5.604E-3 1 1
6 IPR032403 Exo84 C InterPro 2.669E-4 5.095E-4 1.857E-3 5.604E-3 1 1
7 IPR007191 Sec8 exocyst InterPro 2.669E-4 5.095E-4 1.857E-3 5.604E-3 1 1
8 PF03081 Exo70 Pfam 2.669E-4 5.095E-4 1.857E-3 5.604E-3 1 1
9 IPR004140 Exo70 InterPro 2.669E-4 5.095E-4 1.857E-3 5.604E-3 1 1
10 PF16528 Exo84 C Pfam 2.669E-4 5.095E-4 1.857E-3 5.604E-3 1 1
11 PF04048 Sec8 exocyst Pfam 2.669E-4 5.095E-4 1.857E-3 5.604E-3 1 1
12 IPR014812 Vps51 InterPro 8.005E-4 1.401E-3 5.106E-3 1.681E-2 1 3
13 IPR010326 EXOC3/Sec6 InterPro 1.334E-3 2.001E-3 7.293E-3 2.801E-2 1 5
14 PF06046 Sec6 Pfam 1.334E-3 2.001E-3 7.293E-3 2.801E-2 1 5
15 IPR010989 t-SNARE InterPro 1.142E-2 1.599E-2
5.830E-2
2.399E-1
 1 43
Show 10 more annotations

7: Pathway [Display Chart] 5 input genes in category / 12 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1268849 VxPx cargo-targeting to cilium BioSystems: REACTOME 1.057E-14 1.269E-13 3.937E-13 1.269E-13 5 22
2 1268747 Insulin processing BioSystems: REACTOME 3.946E-14 2.368E-13 7.347E-13 4.735E-13 5 28
3 1268848 Cargo trafficking to the periciliary membrane BioSystems: REACTOME 1.152E-12 4.609E-12 1.430E-11 1.383E-11 5 53
4 1269896 Translocation of GLUT4 to the plasma membrane BioSystems: REACTOME 2.598E-12 7.794E-12 2.419E-11 3.118E-11 5 62
5 1268746 Peptide hormone metabolism BioSystems: REACTOME 1.867E-11 4.481E-11 1.391E-10 2.241E-10 5 91
6 138026 Insulin Pathway BioSystems: Pathway Interaction Database 6.151E-10 1.160E-9 3.599E-9 7.382E-9 4 43
7 137954 Arf6 trafficking events BioSystems: Pathway Interaction Database 6.766E-10 1.160E-9 3.599E-9 8.119E-9 4 44
8 1268846 Cilium Assembly BioSystems: REACTOME 8.283E-10 1.243E-9 3.856E-9 9.940E-9 5 192
9 1268838 Organelle biogenesis and maintenance BioSystems: REACTOME 1.498E-8 1.997E-8 6.198E-8 1.797E-7 5 341
10 137918 Stabilization and expansion of the E-cadherin adherens junction BioSystems: Pathway Interaction Database 1.000E-4 1.200E-4 3.725E-4 1.200E-3 2 40
11 137994 CDC42 signaling events BioSystems: Pathway Interaction Database 2.780E-2 3.033E-2
9.412E-2
3.336E-1
 1 70
Show 6 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 130 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12687004 The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. Pubmed 1.861E-19 1.210E-17 6.591E-17 2.419E-17 5 9
2 11406615 The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. Pubmed 1.861E-19 1.210E-17 6.591E-17 2.419E-17 5 9
3 14525976 Ral GTPases regulate exocyst assembly through dual subunit interactions. Pubmed 3.722E-19 1.613E-17 8.788E-17 4.839E-17 5 10
4 26582389 Arl13b and the exocyst interact synergistically in ciliogenesis. Pubmed 8.460E-16 2.200E-14 1.199E-13 1.100E-13 4 6
5 9405631 Subunit structure of the mammalian exocyst complex. Pubmed 8.460E-16 2.200E-14 1.199E-13 1.100E-13 4 6
6 9655500 Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Pubmed 7.106E-15 1.540E-13 8.389E-13 9.238E-13 4 9
7 11865051 Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. Pubmed 1.077E-12 2.000E-11 1.090E-10 1.400E-10 3 3
8 23956138 Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. Pubmed 2.391E-12 3.885E-11 2.117E-10 3.108E-10 5 183
9 15037366 The exocyst complex in polarized exocytosis. Pubmed 2.154E-11 2.800E-10 1.526E-9 2.800E-9 3 6
10 12738960 NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Pubmed 2.154E-11 2.800E-10 1.526E-9 2.800E-9 3 6
11 24056301 The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response. Pubmed 4.898E-10 5.789E-9 3.154E-8 6.368E-8 3 15
12 21241894 RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Pubmed 7.320E-10 7.930E-9 4.321E-8 9.516E-8 3 17
13 12954101 Immunological characterization of exocyst complex subunits in cell differentiation. Pubmed 1.371E-8 1.048E-7 5.713E-7 1.782E-6 2 2
14 26283729 Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. Pubmed 1.371E-8 1.048E-7 5.713E-7 1.782E-6 2 2
15 15880602 Association between single-nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population. Pubmed 1.371E-8 1.048E-7 5.713E-7 1.782E-6 2 2
16 15878854 Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis. Pubmed 1.371E-8 1.048E-7 5.713E-7 1.782E-6 2 2
17 26892009 Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells. Pubmed 1.371E-8 1.048E-7 5.713E-7 1.782E-6 2 2
18 23037926 Exocyst Sec10 is involved in basolateral protein translation and translocation in the endoplasmic reticulum. Pubmed 4.113E-8 2.674E-7 1.457E-6 5.347E-6 2 3
19 19889837 Sec3-containing exocyst complex is required for desmosome assembly in mammalian epithelial cells. Pubmed 4.113E-8 2.674E-7 1.457E-6 5.347E-6 2 3
20 21658605 SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Pubmed 4.113E-8 2.674E-7 1.457E-6 5.347E-6 2 3
21 21389209 The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones. Pubmed 8.226E-8 4.456E-7 2.428E-6 1.069E-5 2 4
22 20579884 Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex. Pubmed 8.226E-8 4.456E-7 2.428E-6 1.069E-5 2 4
23 26350970 Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. Pubmed 8.226E-8 4.456E-7 2.428E-6 1.069E-5 2 4
24 22172676 Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex. Pubmed 8.226E-8 4.456E-7 2.428E-6 1.069E-5 2 4
25 18480549 Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. Pubmed 1.371E-7 7.129E-7 3.884E-6 1.782E-5 2 5
26 16601687 Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. Pubmed 2.056E-7 1.028E-6 5.602E-6 2.673E-5 2 6
27 21639856 Exo70, a subunit of the exocyst complex, interacts with SNEV(hPrp19/hPso4) and is involved in pre-mRNA splicing. Pubmed 2.879E-7 1.336E-6 7.282E-6 3.742E-5 2 7
28 21148297 A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Pubmed 2.879E-7 1.336E-6 7.282E-6 3.742E-5 2 7
29 22534017 Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation. Pubmed 4.934E-7 2.212E-6 1.205E-5 6.414E-5 2 9
30 18329369 Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. Pubmed 1.069E-6 4.632E-6 2.524E-5 1.390E-4 2 13
31 29158485 Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Pubmed 2.096E-6 8.790E-6 4.789E-5 2.725E-4 2 18
32 9630218 Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
33 8982167 The mammalian brain rsec6/8 complex. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
34 11054383 IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
35 20053792 Exocyst Sec10 protects epithelial barrier integrity and enhances recovery following oxidative stress, by activation of the MAPK pathway. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
36 24949832 Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
37 19006485 Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
38 9119050 Identification and characterization of homologues of the Exocyst component Sec10p. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
39 23207790 Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
40 24331928 Exo70 isoform switching upon epithelial-mesenchymal transition mediates cancer cell invasion. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
41 26040895 The exocyst gene Sec10 regulates renal epithelial monolayer homeostasis and apoptotic sensitivity. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
42 19297529 The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
43 21034848 EXO70 protein influences dengue virus secretion. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
44 10608757 Transient T cell receptor beta-chain variable region-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotyping. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
45 10925150 Transcriptional regulation of gene expression of sec6, a component of mammalian exocyst complex at the synapse. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
46 25725287 Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
47 28729419 The exocyst is required for photoreceptor ciliogenesis and retinal development. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
48 25380822 The exocyst is required for trypanosome invasion and the repair of mechanical plasma membrane wounds. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
49 28698570 Exo70 is an independent prognostic factor in colon cancer. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
50 22595671 ERK1/2 regulate exocytosis through direct phosphorylation of the exocyst component Exo70. Pubmed 1.309E-4 3.211E-4 1.750E-3 1.702E-2 1 1
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 188 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:EXOC6B EXOC6B interactions 1.405E-15 2.642E-13 1.537E-12 2.642E-13 5 21
2 int:IL1R2 IL1R2 interactions 6.647E-14 5.557E-12 3.232E-11 1.250E-11 5 43
3 int:EXOC6 EXOC6 interactions 1.059E-13 5.557E-12 3.232E-11 1.991E-11 5 47
4 int:EXOC2 EXOC2 interactions 1.182E-13 5.557E-12 3.232E-11 2.223E-11 5 48
5 int:EXOC3 EXOC3 interactions 2.891E-13 1.083E-11 6.300E-11 5.436E-11 5 57
6 int:EXOC8 EXOC8 interactions 3.457E-13 1.083E-11 6.300E-11 6.499E-11 5 59
7 int:EXOC7 EXOC7 interactions 4.469E-13 1.200E-11 6.980E-11 8.401E-11 5 62
8 int:EXOC4 EXOC4 interactions 6.669E-13 1.393E-11 8.103E-11 1.254E-10 5 67
9 int:EXOC5 EXOC5 interactions 6.669E-13 1.393E-11 8.103E-11 1.254E-10 5 67
10 int:RALA RALA interactions 1.037E-12 1.950E-11 1.134E-10 1.950E-10 5 73
11 int:EXOC1 EXOC1 interactions 6.350E-12 1.085E-10 6.313E-10 1.194E-9 5 104
12 int:DTNBP1 DTNBP1 interactions 1.706E-8 2.673E-7 1.555E-6 3.208E-6 4 137
13 int:RALB RALB interactions 9.098E-8 1.316E-6 7.652E-6 1.710E-5 3 38
14 int:CA14 CA14 interactions 1.864E-7 2.503E-6 1.456E-5 3.504E-5 3 48
15 int:KXD1 KXD1 interactions 2.112E-7 2.647E-6 1.539E-5 3.970E-5 3 50
16 int:EPHA1 EPHA1 interactions 8.829E-7 1.037E-5 6.034E-5 1.660E-4 3 80
17 int:DLG3 DLG3 interactions 1.024E-6 1.132E-5 6.584E-5 1.924E-4 3 84
18 int:SCN2B SCN2B interactions 1.178E-6 1.231E-5 7.159E-5 2.215E-4 3 88
19 int:GRIN2B GRIN2B interactions 1.582E-6 1.565E-5 9.105E-5 2.974E-4 3 97
20 int:STX11 STX11 interactions 2.128E-6 2.000E-5 1.163E-4 4.001E-4 3 107
21 int:HGS HGS interactions 2.791E-5 2.498E-4 1.453E-3 5.247E-3 3 252
22 int:DSN1 DSN1 interactions 8.415E-5 7.191E-4 4.182E-3 1.582E-2 2 52
23 int:IFT20 IFT20 interactions 9.079E-5 7.421E-4 4.316E-3 1.707E-2 2 54
24 int:COG6 COG6 interactions 1.999E-4 1.566E-3 9.108E-3 3.758E-2 2 80
25 int:MYO5A MYO5A interactions 2.100E-4 1.579E-3 9.187E-3 3.949E-2 2 82
26 int:SIGLECL1 SIGLECL1 interactions 2.940E-4 2.089E-3 1.215E-2
5.527E-2
 2 97
27 int:RAB8A RAB8A interactions 3.001E-4 2.089E-3 1.215E-2
5.641E-2
 2 98
28 int:PNKD PNKD interactions 3.187E-4 2.140E-3 1.245E-2
5.992E-2
 2 101
29 int:BECN1 BECN1 interactions 4.800E-4 3.112E-3 1.810E-2
9.024E-2
 2 124
30 int:USHBP1 USHBP1 interactions 5.356E-4 3.356E-3 1.952E-2
1.007E-1
 2 131
31 int:DISC1 DISC1 interactions 5.855E-4 3.551E-3 2.065E-2
1.101E-1
 2 137
32 int:CCDC85B CCDC85B interactions 6.829E-4 4.012E-3 2.333E-2
1.284E-1
 2 148
33 int:SETDB1 SETDB1 interactions 7.107E-4 4.049E-3 2.355E-2
1.336E-1
 2 151
34 int:SCLT1 SCLT1 interactions 7.486E-4 4.139E-3 2.408E-2
1.407E-1
 2 155
35 int:BSG BSG interactions 9.528E-4 5.118E-3 2.977E-2
1.791E-1
 2 175
36 int:PRPF19 PRPF19 interactions 1.242E-3 6.485E-3 3.772E-2
2.335E-1
 2 200
37 int:EXOC3L2 EXOC3L2 interactions 1.412E-3 7.172E-3 4.172E-2
2.654E-1
 1 5
38 int:OAS1 OAS1 interactions 1.976E-3 9.775E-3
5.685E-2
3.714E-1
 1 7
39 int:PCM1 PCM1 interactions 2.314E-3 1.116E-2
6.489E-2
4.351E-1
 2 274
40 int:DHX34 DHX34 interactions 2.540E-3 1.165E-2
6.773E-2
4.775E-1
 1 9
41 int:TRARG1 TRARG1 interactions 2.540E-3 1.165E-2
6.773E-2
4.775E-1
 1 9
42 int:TTC23L TTC23L interactions 2.822E-3 1.263E-2
7.346E-2
5.304E-1
 1 10
43 int:RUBCN RUBCN interactions 3.103E-3 1.326E-2
7.712E-2
5.834E-1
 1 11
44 int:IQCB1 IQCB1 interactions 3.103E-3 1.326E-2
7.712E-2
5.834E-1
 2 318
45 int:SSC5D SSC5D interactions 3.385E-3 1.414E-2
8.225E-2
6.364E-1
 1 12
46 int:ICA1 ICA1 interactions 3.667E-3 1.436E-2
8.353E-2
6.893E-1
 1 13
47 int:SPACA9 SPACA9 interactions 3.667E-3 1.436E-2
8.353E-2
6.893E-1
 1 13
48 int:KIZ KIZ interactions 3.667E-3 1.436E-2
8.353E-2
6.893E-1
 1 13
49 int:HDDC3 HDDC3 interactions 3.948E-3 1.515E-2
8.811E-2
7.423E-1
 1 14
50 int:METAP1 METAP1 interactions 4.230E-3 1.590E-2
9.250E-2
7.952E-1
 1 15
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1q42.2 1q42.2 3.601E-3 6.299E-3 1.438E-2 1.801E-2 1 25
2 14q22.3 14q22.3 3.889E-3 6.299E-3 1.438E-2 1.945E-2 1 27
3 7q31 7q31 3.889E-3 6.299E-3 1.438E-2 1.945E-2 1 27
4 5p15.33 5p15.33 5.039E-3 6.299E-3 1.438E-2 2.520E-2 1 35
5 17q25.1 17q25.1 1.192E-2 1.192E-2 2.721E-2
5.958E-2
 1 83

11: Transcription Factor Binding Site [Display Chart] 2 input genes in category / 2 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 5 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1055 Exocyst complex genenames.org 7.588E-18 7.588E-18 7.588E-18 7.588E-18 5 9

13: Coexpression [Display Chart] 5 input genes in category / 297 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20068100-TableS5 Human Leukemia Bomben10 212genes GeneSigDB 3.747E-4 4.341E-2
2.723E-1
1.113E-1
 2 143
2 M3366 Genes up-regulated in comparison of Th2cells versus induced regulatory T cell (Treg). MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 4.341E-2
2.723E-1
2.149E-1
 2 199
3 M7861 Genes down-regulated in CD4 [GeneID=920] T cells treated with IL1B and IL6 [GeneID=3553;3569] versus those also treated with TGFB1 [GeneID=7040]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 4.341E-2
2.723E-1
2.171E-1
 2 200
4 M8869 Genes down-regulated in common lymphoid progenitors versus CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 4.341E-2
2.723E-1
2.171E-1
 2 200
5 M8842 Genes down-regulated in multipotent progenitors versus common lymphoid progenitors. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 4.341E-2
2.723E-1
2.171E-1
 2 200
6 M2196 Genes significantly de-regulated (p < 0.05) by MIR21 [GeneID=406991] in A172 cells (glioma). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.517E-3 4.726E-2
2.964E-1
4.504E-1
 2 289
7 M9565 Up-regulated genes whose expression correlates with copy number gains in pancreatic adenocarcinoma cell lines and primary tumor specimens. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.590E-3 4.726E-2
2.964E-1
4.723E-1
 2 296
8 M12674 Genes down-regulated in MCF7 cells (breast cancer) engineered to conditionally express LMO4 [GeneID=8543] by a Tet Off system. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.227E-3 4.726E-2
2.964E-1
6.613E-1
 2 351
9 16465392-Table1 Human Breast Mewani06 17genes raf1 GeneSigDB 3.238E-3 4.726E-2
2.964E-1
9.616E-1
 1 15
10 M5754 Genes down-regulated more than two-fold in lymphoblastoid cell lines from European population compared to those from Asian population. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.530E-3 4.726E-2
2.964E-1
1.000E0
 1 21
11 M13766 Genes within amplicon 5p15 identified in a copy number alterations study of 191 breast tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.607E-3 4.726E-2
2.964E-1
1.000E0
 1 26
12 16514666-Table2 Rat Immune Molloy06 46genes GeneSigDB 6.037E-3 4.726E-2
2.964E-1
1.000E0
 1 28
13 19118092-Table4 Mouse Lung not cancer Cavarra09 43genes GeneSigDB 7.971E-3 4.726E-2
2.964E-1
1.000E0
 1 37
14 18974375-TableS4 Human Lymphoma Chng09 50genes GeneSigDB 8.186E-3 4.726E-2
2.964E-1
1.000E0
 1 38
15 15300801-Table1 Human Breast Nagai04 46genes ERpos GeneSigDB 8.400E-3 4.726E-2
2.964E-1
1.000E0
 1 39
16 M1760 Genes down-regulated after Cre-lox knockout of LSD1 [GeneID=23028] in pituitary. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.400E-3 4.726E-2
2.964E-1
1.000E0
 1 39
17 M2679 Genes down-regulated in HEK293 cells (kidney fibroblasts) expressing constitutively active form of CTNNB1 [Gene ID=1499] gene. MSigDB C6: Oncogenic Signatures (v6.0) 9.259E-3 4.726E-2
2.964E-1
1.000E0
 1 43
18 M10797 Genes whose expression peaked at 60 min after stimulation of HeLa cells with EGF [GeneID=1950]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.688E-3 4.726E-2
2.964E-1
1.000E0
 1 45
19 14678982-Table3 Human Stomach Kim03 57genes UpRegulated GeneSigDB 1.119E-2 4.726E-2
2.964E-1
1.000E0
 1 52
20 M18168 Genes up-regulated in MEF cells (embryonic fibroblast) isolated from NRAS [GeneID=4893] knockout mice. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.461E-2 4.726E-2
2.964E-1
1.000E0
 1 68
21 18927307-tableS4 Human Colon Allen08 124genes GeneSigDB 1.674E-2 4.726E-2
2.964E-1
1.000E0
 1 78
22 M19891 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 12. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.696E-2 4.726E-2
2.964E-1
1.000E0
 1 79
23 16909116-Table2 Mouse StemCell Castellano07 104genes GeneSigDB 1.696E-2 4.726E-2
2.964E-1
1.000E0
 1 79
24 19174476-SuppTable1 Human Lung not cancer Howrylak09 100genes GeneSigDB 1.909E-2 4.726E-2
2.964E-1
1.000E0
 1 89
25 M1666 Strongly down-regulated at 8-96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.973E-2 4.726E-2
2.964E-1
1.000E0
 1 92
26 15257931-SuppTableC Human Leukemia Teuffel04 125genes GeneSigDB 2.185E-2 4.726E-2
2.964E-1
1.000E0
 1 102
27 M1917 Genes up-regulated in neural stem cells (NSC) at both 36 h and 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.312E-2 4.726E-2
2.964E-1
1.000E0
 1 108
28 M18762 'Late-TGFB1 signature': genes overexpressed in primary hepatocytes at a late phase of TGFB1 [GeneID=7040] treatment; is associated with a more invasive phenotype. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.334E-2 4.726E-2
2.964E-1
1.000E0
 1 109
29 M8803 Genes up-regulated in Foxp3-ires-GFP T reg (FOXP3+ [GeneID=50943]): B6 versus NOD background. MSigDB C7: Immunologic Signatures (v6.0) 2.418E-2 4.726E-2
2.964E-1
1.000E0
 1 113
30 M4113 Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC2 [GeneID=3066] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.440E-2 4.726E-2
2.964E-1
1.000E0
 1 114
31 M8929 Genes up-regulated in CD4 [GeneID=920] Th17 T cells: enriched versus negative. MSigDB C7: Immunologic Signatures (v6.0) 2.567E-2 4.726E-2
2.964E-1
1.000E0
 1 120
32 15486989-table2 Rat Prostate Reyes05 189genes GeneSigDB 2.588E-2 4.726E-2
2.964E-1
1.000E0
 1 121
33 M8933 Genes up-regulated in CD4 [GeneID=920] T cells: naïve versus Th1. MSigDB C7: Immunologic Signatures (v6.0) 2.694E-2 4.726E-2
2.964E-1
1.000E0
 1 126
34 M6767 Genes down-regulated in atypical ductal hyperplastic tissues from patients with (ADHC) breast cancer vs those without the cancer (ADH). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.863E-2 4.726E-2
2.964E-1
1.000E0
 1 134
35 19168792-TableS5 Human Leukemia Figueroa09 199genes GeneSigDB 2.884E-2 4.726E-2
2.964E-1
1.000E0
 1 135
36 M8918 Genes up-regulated in CD44 low [GeneID=960] CD8 T cells: wildtype versus RC3H1 [GeneID=149041] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.884E-2 4.726E-2
2.964E-1
1.000E0
 1 135
37 M471 Genes down-regulated in NIH3T3 cells (fibroblast): control versus stimulated with IFN-b. MSigDB C7: Immunologic Signatures (v6.0) 2.884E-2 4.726E-2
2.964E-1
1.000E0
 1 135
38 M6085 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (2h) versus IL4 [GeneID=3565] (2h). MSigDB C7: Immunologic Signatures (v6.0) 2.968E-2 4.726E-2
2.964E-1
1.000E0
 1 139
39 M16384 Genes down-regulated in MFCF-7 cells (breast cancer) upon stable autocrine expression of HG1 [GeneID=2688]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.032E-2 4.726E-2
2.964E-1
1.000E0
 1 142
40 M2113 Genes whose expression in brain significantly and negatively correlated with the duration of all psychiatric disorders studied. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.095E-2 4.726E-2
2.964E-1
1.000E0
 1 145
41 M442 Genes up-regulated in peripheral blood monocytes (PBMC): control versus IL-12 stimulation. MSigDB C7: Immunologic Signatures (v6.0) 3.158E-2 4.726E-2
2.964E-1
1.000E0
 1 148
42 M9106 Genes down-regulated in CD4 T conv: control versus over-expression of PBX1 and FOXP3 [GeneID=5087;50943]. MSigDB C7: Immunologic Signatures (v6.0) 3.284E-2 4.726E-2
2.964E-1
1.000E0
 1 154
43 M2872 Genes down-regulated in HEL cells (erythroleukemia) after knockdown of JAK2 [Gene ID=3717] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 3.347E-2 4.726E-2
2.964E-1
1.000E0
 1 157
44 19351846-SuppTable2 Human Prostate Wang09 181genes GeneSigDB 3.431E-2 4.726E-2
2.964E-1
1.000E0
 1 161
45 M8121 Genes down-regulated in IL10 [GeneID=3586] knockout macrophages stimulated by IL10 [GeneID=3586] versus NFKB1 [GeneID=4790] knockout macrophages stimulated by IL10 [GeneID=3586] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 3.452E-2 4.726E-2
2.964E-1
1.000E0
 1 162
46 M8949 Genes up-regulated in T conv cells from aged PPARG [GeneID=5468] knockout: visceral adipose tissue versus lymph node. MSigDB C7: Immunologic Signatures (v6.0) 3.495E-2 4.726E-2
2.964E-1
1.000E0
 1 164
47 M8926 Genes down-regulated in CD4 [GeneID=920] T cells: naïve versus Th1. MSigDB C7: Immunologic Signatures (v6.0) 3.495E-2 4.726E-2
2.964E-1
1.000E0
 1 164
48 M6853 Genes up-regulated in spleens: LPS versus monophosphoryl lipid A. MSigDB C7: Immunologic Signatures (v6.0) 3.558E-2 4.726E-2
2.964E-1
1.000E0
 1 167
49 M2990 Genes down-regulated in B lymphocytes with ZFX [GeneID=7543] knockout: control versus stimulated by anti-IgM for 2h. MSigDB C7: Immunologic Signatures (v6.0) 3.579E-2 4.726E-2
2.964E-1
1.000E0
 1 168
50 12714683-Table5 Human Breast Ma02 200genes grade GeneSigDB 3.600E-2 4.726E-2
2.964E-1
1.000E0
 1 169
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 66 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 3 input genes in category / 43 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 5 input genes in category / 246 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-3074-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.087E-5 3.583E-3 2.180E-2 5.133E-3 2 105
2 hsa-miR-656-3p:Functional MTI Functional MTI miRTarbase 2.913E-5 3.583E-3 2.180E-2 7.165E-3 2 124
3 hsa-miR-532-5p:TargetScan hsa-miR-532-5p TargetScan 5.807E-5 4.148E-3 2.524E-2 1.428E-2 2 175
4 hsa-miR-8063:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.359E-5 4.148E-3 2.524E-2 1.810E-2 2 197
5 hsa-miR-4698:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.846E-5 4.148E-3 2.524E-2 2.176E-2 2 216
6 hsa-miR-4446-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.012E-4 4.148E-3 2.524E-2 2.489E-2 2 231
7 hsa-miR-196a-5p:TargetScan hsa-miR-196a-5p TargetScan 1.454E-4 4.236E-3 2.577E-2 3.576E-2 2 277
8 hsa-miR-196b-5p:TargetScan hsa-miR-196b-5p TargetScan 1.454E-4 4.236E-3 2.577E-2 3.576E-2 2 277
9 hsa-miR-802:TargetScan hsa-miR-802 TargetScan 1.550E-4 4.236E-3 2.577E-2 3.812E-2 2 286
10 hsa-miR-627-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.797E-4 4.255E-3 2.589E-2 4.420E-2 2 308
11 hsa-miR-4753-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.903E-4 4.255E-3 2.589E-2 4.681E-2 2 317
12 hsa-miR-130b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.240E-4 4.591E-3 2.794E-2
5.509E-2
 2 344
13 hsa-miR-3684:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.314E-3 2.487E-2
1.513E-1
3.233E-1
 1 19
14 hsa-miR-99a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.282E-3 2.571E-2
1.564E-1
5.614E-1
 1 33
15 hsa-miR-3200-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.351E-3 2.571E-2
1.564E-1
5.784E-1
 1 34
16 hsa-miR-625-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.696E-3 2.571E-2
1.564E-1
6.633E-1
 1 39
17 hsa-miR-6808-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.766E-3 2.571E-2
1.564E-1
6.803E-1
 1 40
18 hsa-miR-218-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.904E-3 2.571E-2
1.564E-1
7.143E-1
 1 42
19 hsa-miR-591:Functional MTI Functional MTI miRTarbase 2.973E-3 2.571E-2
1.564E-1
7.313E-1
 1 43
20 hsa-miR-7973:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.042E-3 2.571E-2
1.564E-1
7.483E-1
 1 44
21 hsa-miR-563:PITA hsa-miR-563:PITA TOP PITA 3.111E-3 2.571E-2
1.564E-1
7.653E-1
 1 45
22 hsa-miR-99b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.456E-3 2.571E-2
1.564E-1
8.502E-1
 1 50
23 hsa-miR-4777-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.594E-3 2.571E-2
1.564E-1
8.841E-1
 1 52
24 GTGTCAA,MIR-514:MSigDB GTGTCAA,MIR-514:MSigDB MSigDB 4.077E-3 2.571E-2
1.564E-1
1.000E0
 1 59
25 CTAGGAA,MIR-384:MSigDB CTAGGAA,MIR-384:MSigDB MSigDB 4.146E-3 2.571E-2
1.564E-1
1.000E0
 1 60
26 hsa-miR-1273g-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.284E-3 2.571E-2
1.564E-1
1.000E0
 1 62
27 hsa-miR-6740-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.422E-3 2.571E-2
1.564E-1
1.000E0
 1 64
28 hsa-miR-4804-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.422E-3 2.571E-2
1.564E-1
1.000E0
 1 64
29 hsa-miR-651-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.491E-3 2.571E-2
1.564E-1
1.000E0
 1 65
30 hsa-miR-942-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.767E-3 2.571E-2
1.564E-1
1.000E0
 1 69
31 hsa-miR-1266-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.836E-3 2.571E-2
1.564E-1
1.000E0
 1 70
32 hsa-miR-3668:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.836E-3 2.571E-2
1.564E-1
1.000E0
 1 70
33 hsa-miR-6502-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.836E-3 2.571E-2
1.564E-1
1.000E0
 1 70
34 hsa-miR-4760-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.905E-3 2.571E-2
1.564E-1
1.000E0
 1 71
35 hsa-miR-5586-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.905E-3 2.571E-2
1.564E-1
1.000E0
 1 71
36 hsa-miR-875-5p:TargetScan hsa-miR-875-5p TargetScan 5.042E-3 2.571E-2
1.564E-1
1.000E0
 1 73
37 hsa-miR-648:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.111E-3 2.571E-2
1.564E-1
1.000E0
 1 74
38 hsa-miR-203a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.111E-3 2.571E-2
1.564E-1
1.000E0
 1 74
39 hsa-miR-7844-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.180E-3 2.571E-2
1.564E-1
1.000E0
 1 75
40 hsa-miR-4720-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.180E-3 2.571E-2
1.564E-1
1.000E0
 1 75
41 hsa-miR-888-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.318E-3 2.571E-2
1.564E-1
1.000E0
 1 77
42 hsa-miR-34a-3p:Functional MTI Functional MTI miRTarbase 5.594E-3 2.571E-2
1.564E-1
1.000E0
 1 81
43 hsa-miR-382-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.594E-3 2.571E-2
1.564E-1
1.000E0
 1 81
44 hsa-miR-642a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.663E-3 2.571E-2
1.564E-1
1.000E0
 1 82
45 hsa-miR-642b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.663E-3 2.571E-2
1.564E-1
1.000E0
 1 82
46 hsa-miR-371-3p:mirSVR highEffct hsa-miR-371-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.732E-3 2.571E-2
1.564E-1
1.000E0
 1 83
47 hsa-miR-187-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.801E-3 2.571E-2
1.564E-1
1.000E0
 1 84
48 hsa-miR-4802-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.869E-3 2.571E-2
1.564E-1
1.000E0
 1 85
49 hsa-miR-5585-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.145E-3 2.571E-2
1.564E-1
1.000E0
 1 89
50 hsa-miR-548ay-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.214E-3 2.571E-2
1.564E-1
1.000E0
 1 90
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 1563 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000000441 beta-hydroxybutyrate Stitch 4.679E-6 7.313E-3
5.800E-2
 7.313E-3 3 179
2 CID000102191 V0509 Stitch 1.641E-5 1.282E-2
1.017E-1
 2.565E-2 3 272
3 CID000026491 Bd37 Stitch 4.378E-4 3.223E-2
2.556E-1
6.842E-1
 1 2
4 CID000019212 ecdysone Stitch 5.947E-4 3.223E-2
2.556E-1
9.295E-1
 2 178
5 1644 UP radicicol, diheterospora chlamydosporia; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.013E-4 3.223E-2
2.556E-1
9.399E-1
 2 179
6 3279 DN Primaquine diphosphate [63-45-6]; Down 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 6.490E-4 3.223E-2
2.556E-1
1.000E0
 2 186
7 2353 DN Metoclopramide monohydrochloride [7232-21-5]; Down 200; 11.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 6.490E-4 3.223E-2
2.556E-1
1.000E0
 2 186
8 1334 DN Myricetin [529-44-2]; Down 200; 12.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 6.771E-4 3.223E-2
2.556E-1
1.000E0
 2 190
9 3352 DN Propantheline bromide [50-34-0]; Down 200; 9uM; MCF7; HT HG-U133A Broad Institute CMAP Down 6.771E-4 3.223E-2
2.556E-1
1.000E0
 2 190
10 1023 DN wortmannin from Penicillium funiculosum; Down 200; 0.01uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 6.842E-4 3.223E-2
2.556E-1
1.000E0
 2 191
11 3753 DN Famprofazone [22881-35-2]; Down 200; 10.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 6.913E-4 3.223E-2
2.556E-1
1.000E0
 2 192
12 2166 DN Succinylsulfathiazole [116-43-8]; Down 200; 11.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 6.985E-4 3.223E-2
2.556E-1
1.000E0
 2 193
13 6235 DN Raloxifene hydrochloride [82640-04-8]; Down 200; 7.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 6.985E-4 3.223E-2
2.556E-1
1.000E0
 2 193
14 7189 UP Iopamidol [60166-93-0]; Up 200; 5.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.057E-4 3.223E-2
2.556E-1
1.000E0
 2 194
15 4333 DN PHA-00851261E [724719-49-7]; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.130E-4 3.223E-2
2.556E-1
1.000E0
 2 195
16 2517 DN Cephalothin sodium salt [58-71-9]; Down 200; 9.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 7.130E-4 3.223E-2
2.556E-1
1.000E0
 2 195
17 2106 DN Fenspiride hydrochloride [5053-08-7]; Down 200; 13.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.130E-4 3.223E-2
2.556E-1
1.000E0
 2 195
18 2628 DN Cephalexin monohydrate [23325-78-2]; Down 200; 11uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.203E-4 3.223E-2
2.556E-1
1.000E0
 2 196
19 3306 DN Epiandrosterone [481-29-8]; Down 200; 13.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.203E-4 3.223E-2
2.556E-1
1.000E0
 2 196
20 5521 DN Telenzepine dihydrochloride [147416-96-4]; Down 200; 9uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.203E-4 3.223E-2
2.556E-1
1.000E0
 2 196
21 5052 DN Allantoin [97-59-6]; Down 200; 25.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.203E-4 3.223E-2
2.556E-1
1.000E0
 2 196
22 7186 UP Cefotaxime sodium salt [64485-93-4]; Up 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.203E-4 3.223E-2
2.556E-1
1.000E0
 2 196
23 7087 DN CAY10397; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.203E-4 3.223E-2
2.556E-1
1.000E0
 2 196
24 3206 DN Dobutamine hydrochloride [49745-95-1]; Down 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.203E-4 3.223E-2
2.556E-1
1.000E0
 2 196
25 4796 UP Colistin sulfate [1264-72-8]; Up 200; 3uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.276E-4 3.223E-2
2.556E-1
1.000E0
 2 197
26 2635 DN Ritodrine hydrochloride [23239-51-2]; Down 200; 12.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.276E-4 3.223E-2
2.556E-1
1.000E0
 2 197
27 1944 DN Moroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; PC3; HG-U133A Broad Institute CMAP Down 7.276E-4 3.223E-2
2.556E-1
1.000E0
 2 197
28 4802 UP Pregnenolone [145-13-1]; Up 200; 12.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.276E-4 3.223E-2
2.556E-1
1.000E0
 2 197
29 1322 DN Cephalosporanic acid, 7-amino [957-68-6]; Down 200; 14.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 7.276E-4 3.223E-2
2.556E-1
1.000E0
 2 197
30 5536 DN Scoulerine [6451-73-6]; Down 200; 12.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.276E-4 3.223E-2
2.556E-1
1.000E0
 2 197
31 5306 DN Propofol [2078-54-8]; Down 200; 22.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.349E-4 3.223E-2
2.556E-1
1.000E0
 2 198
32 1955 UP Haloperidol [52-86-8]; Up 200; 10.6uM; PC3; HG-U133A Broad Institute CMAP Up 7.349E-4 3.223E-2
2.556E-1
1.000E0
 2 198
33 5837 DN Streptomycin sulfate [3810-74-0]; Down 200; 2.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.349E-4 3.223E-2
2.556E-1
1.000E0
 2 198
34 6346 DN Sulfasalazine [599-79-1]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.349E-4 3.223E-2
2.556E-1
1.000E0
 2 198
35 6237 DN Cefepime hydrochloride [123171-59-5]; Down 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.349E-4 3.223E-2
2.556E-1
1.000E0
 2 198
36 1295 DN Testosterone propionate [57-85-2]; Down 200; 11.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 7.423E-4 3.223E-2
2.556E-1
1.000E0
 2 199
37 CID000003892 NSC339663 Stitch 1.168E-3 4.355E-2
3.455E-1
1.000E0
 2 250
38 CID000121933 taurodehydrocholate Stitch 1.969E-3 4.355E-2
3.455E-1
1.000E0
 1 9
39 CID011291331 SureCN3420785 Stitch 1.969E-3 4.355E-2
3.455E-1
1.000E0
 1 9
40 CID000001822 AC1L1CBF Stitch 2.108E-3 4.355E-2
3.455E-1
1.000E0
 2 337
41 CID000007897 Aldol Stitch 7.204E-3 4.355E-2
3.455E-1
1.000E0
 1 33
42 CID000170325 Agent QL Stitch 9.596E-3 4.355E-2
3.455E-1
1.000E0
 1 44
43 CID002733618 Frie Mao 1-43 Stitch 1.328E-2 4.355E-2
3.455E-1
1.000E0
 1 61
44 CID000148177 perifosine Stitch 1.393E-2 4.355E-2
3.455E-1
1.000E0
 1 64
45 CID000000755 sodium glycocholate Stitch 1.501E-2 4.355E-2
3.455E-1
1.000E0
 1 69
46 CID000000832 L-beta-aspartyl phosphate Stitch 1.501E-2 4.355E-2
3.455E-1
1.000E0
 1 69
47 CID000119102 a-factor Stitch 1.588E-2 4.355E-2
3.455E-1
1.000E0
 1 73
48 CID000445265 AC1L9HP3 Stitch 1.653E-2 4.355E-2
3.455E-1
1.000E0
 1 76
49 CID000004789 phlorizine Stitch 1.718E-2 4.355E-2
3.455E-1
1.000E0
 1 79
50 CID000000713 formamide Stitch 1.847E-2 4.355E-2
3.455E-1
1.000E0
 1 85
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 9 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0521622 Bilateral hydronephrosis DisGeNET BeFree 3.085E-4 2.777E-3 7.856E-3 2.777E-3 1 1
2 C0085413 Polycystic Kidney, Autosomal Dominant DisGeNET Curated 7.812E-4 3.516E-3 9.945E-3 7.031E-3 2 145
3 C0751690 Malignant Peripheral Nerve Sheath Tumor DisGeNET Curated 1.227E-3 3.681E-3 1.041E-2 1.104E-2 2 182
4 C0003460 Anuria DisGeNET Curated 2.466E-3 5.549E-3 1.570E-2 2.220E-2 1 8
5 20081125:Levy Blood pressure GWAS 5.235E-3 9.423E-3 2.666E-2 4.711E-2 1 17