Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc299_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 45 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004435 phosphatidylinositol phospholipase C activity 1.055E-7 2.854E-6 1.254E-5 4.746E-6 3 28
2 GO:0042578 phosphoric ester hydrolase activity 1.269E-7 2.854E-6 1.254E-5 5.708E-6 5 429
3 GO:0004629 phospholipase C activity 2.498E-7 3.746E-6 1.647E-5 1.124E-5 3 37
4 GO:0008081 phosphoric diester hydrolase activity 4.841E-6 5.446E-5 2.394E-4 2.179E-4 3 98
5 GO:0004620 phospholipase activity 9.830E-6 8.847E-5 3.888E-4 4.423E-4 3 124
6 GO:0016298 lipase activity 1.355E-5 1.016E-4 4.467E-4 6.099E-4 3 138
7 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 5.221E-5 2.937E-4 1.291E-3 2.349E-3 2 30
8 GO:0016312 inositol bisphosphate phosphatase activity 5.221E-5 2.937E-4 1.291E-3 2.349E-3 2 30
9 GO:0046030 inositol trisphosphate phosphatase activity 7.983E-5 3.991E-4 1.754E-3 3.592E-3 2 37
10 GO:0052745 inositol phosphate phosphatase activity 1.185E-4 5.291E-4 2.325E-3 5.332E-3 2 45
11 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1.293E-4 5.291E-4 2.325E-3 5.820E-3 2 47
12 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity 7.501E-4 2.813E-3 1.236E-2 3.375E-2 1 2
13 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity 1.125E-3 3.894E-3 1.711E-2
5.062E-2
 1 3
14 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity 1.500E-3 4.218E-3 1.854E-2
6.749E-2
 1 4
15 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity 1.500E-3 4.218E-3 1.854E-2
6.749E-2
 1 4
16 GO:0051425 PTB domain binding 1.500E-3 4.218E-3 1.854E-2
6.749E-2
 1 4
17 GO:0004676 3-phosphoinositide-dependent protein kinase activity 2.998E-3 7.935E-3 3.487E-2
1.349E-1
 1 8
18 GO:0004445 inositol-polyphosphate 5-phosphatase activity 3.372E-3 7.986E-3 3.510E-2
1.517E-1
 1 9
19 GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity 3.372E-3 7.986E-3 3.510E-2
1.517E-1
 1 9
20 GO:0016004 phospholipase activator activity 4.493E-3 9.740E-3 4.281E-2
2.022E-1
 1 12
21 GO:0016791 phosphatase activity 4.545E-3 9.740E-3 4.281E-2
2.045E-1
 2 282
22 GO:0060229 lipase activator activity 5.241E-3 1.072E-2 4.711E-2
2.358E-1
 1 14
23 GO:0043274 phospholipase binding 8.225E-3 1.501E-2
6.598E-2
3.701E-1
 1 22
24 GO:0005543 phospholipid binding 8.324E-3 1.501E-2
6.598E-2
3.746E-1
 2 385
25 GO:0031683 G-protein beta/gamma-subunit complex binding 8.970E-3 1.501E-2
6.598E-2
4.036E-1
 1 24
26 GO:0052828 inositol-3,4-bisphosphate 4-phosphatase activity 9.342E-3 1.501E-2
6.598E-2
4.204E-1
 1 25
27 GO:0017161 inositol-1,3,4-trisphosphate 4-phosphatase activity 9.342E-3 1.501E-2
6.598E-2
4.204E-1
 1 25
28 GO:0030487 inositol-4,5-bisphosphate 5-phosphatase activity 9.342E-3 1.501E-2
6.598E-2
4.204E-1
 1 25
29 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1.120E-2 1.738E-2
7.639E-2
5.040E-1
 1 30
30 GO:0052743 inositol tetrakisphosphate phosphatase activity 1.269E-2 1.836E-2
8.070E-2
5.709E-1
 1 34
31 GO:0005158 insulin receptor binding 1.269E-2 1.836E-2
8.070E-2
5.709E-1
 1 34
32 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1.306E-2 1.836E-2
8.070E-2
5.876E-1
 1 35
33 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1.491E-2 2.033E-2
8.936E-2
6.710E-1
 1 40
34 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1.639E-2 2.169E-2
9.535E-2
7.376E-1
 1 44
35 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1.713E-2 2.203E-2
9.680E-2
7.709E-1
 1 46
Show 30 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 448 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043647 inositol phosphate metabolic process 1.457E-11 6.527E-9 4.362E-8 6.527E-9 5 71
2 GO:0019751 polyol metabolic process 1.429E-10 3.201E-8 2.139E-7 6.402E-8 5 111
3 GO:0006066 alcohol metabolic process 9.977E-8 1.370E-5 9.154E-5 4.470E-5 5 408
4 GO:0006644 phospholipid metabolic process 1.223E-7 1.370E-5 9.154E-5 5.479E-5 5 425
5 GO:0045579 positive regulation of B cell differentiation 2.065E-5 1.677E-3 1.120E-2 9.250E-3 2 19
6 GO:0019722 calcium-mediated signaling 2.245E-5 1.677E-3 1.120E-2 1.006E-2 3 163
7 GO:0046856 phosphatidylinositol dephosphorylation 3.618E-5 2.316E-3 1.548E-2 1.621E-2 2 25
8 GO:0045671 negative regulation of osteoclast differentiation 4.557E-5 2.552E-3 1.705E-2 2.041E-2 2 28
9 GO:0045577 regulation of B cell differentiation 5.242E-5 2.609E-3 1.744E-2 2.348E-2 2 30
10 GO:0050851 antigen receptor-mediated signaling pathway 6.521E-5 2.831E-3 1.892E-2 2.921E-2 3 233
11 GO:0045017 glycerolipid biosynthetic process 7.209E-5 2.831E-3 1.892E-2 3.230E-2 3 241
12 GO:0046839 phospholipid dephosphorylation 7.583E-5 2.831E-3 1.892E-2 3.397E-2 2 36
13 GO:0019932 second-messenger-mediated signaling 8.727E-5 2.853E-3 1.907E-2 3.910E-2 3 257
14 GO:0007223 Wnt signaling pathway, calcium modulating pathway 8.915E-5 2.853E-3 1.907E-2 3.994E-2 2 39
15 GO:1902105 regulation of leukocyte differentiation 1.067E-4 3.186E-3 2.130E-2 4.780E-2 3 275
16 GO:0002762 negative regulation of myeloid leukocyte differentiation 1.412E-4 3.325E-3 2.222E-2
6.327E-2
 2 49
17 GO:0016042 lipid catabolic process 1.422E-4 3.325E-3 2.222E-2
6.371E-2
 3 303
18 GO:0002886 regulation of myeloid leukocyte mediated immunity 1.471E-4 3.325E-3 2.222E-2
6.590E-2
 2 50
19 GO:0051251 positive regulation of lymphocyte activation 1.536E-4 3.325E-3 2.222E-2
6.882E-2
 3 311
20 GO:0002279 mast cell activation involved in immune response 1.592E-4 3.325E-3 2.222E-2
7.130E-2
 2 52
21 GO:0043303 mast cell degranulation 1.592E-4 3.325E-3 2.222E-2
7.130E-2
 2 52
22 GO:0002448 mast cell mediated immunity 1.717E-4 3.325E-3 2.222E-2
7.692E-2
 2 54
23 GO:0010518 positive regulation of phospholipase activity 1.781E-4 3.325E-3 2.222E-2
7.981E-2
 2 55
24 GO:0046850 regulation of bone remodeling 1.781E-4 3.325E-3 2.222E-2
7.981E-2
 2 55
25 GO:0002429 immune response-activating cell surface receptor signaling pathway 1.863E-4 3.339E-3 2.232E-2
8.348E-2
 3 332
26 GO:0002696 positive regulation of leukocyte activation 2.017E-4 3.403E-3 2.274E-2
9.035E-2
 3 341
27 GO:0032418 lysosome localization 2.051E-4 3.403E-3 2.274E-2
9.189E-2
 2 59
28 GO:0050867 positive regulation of cell activation 2.252E-4 3.538E-3 2.364E-2
1.009E-1
 3 354
29 GO:0002443 leukocyte mediated immunity 2.290E-4 3.538E-3 2.364E-2
1.026E-1
 3 356
30 GO:0002768 immune response-regulating cell surface receptor signaling pathway 2.485E-4 3.699E-3 2.472E-2
1.113E-1
 3 366
31 GO:1903706 regulation of hemopoiesis 2.566E-4 3.699E-3 2.472E-2
1.150E-1
 3 370
32 GO:0010517 regulation of phospholipase activity 2.647E-4 3.699E-3 2.472E-2
1.186E-1
 2 67
33 GO:0060193 positive regulation of lipase activity 2.726E-4 3.699E-3 2.472E-2
1.221E-1
 2 68
34 GO:0045576 mast cell activation 2.807E-4 3.699E-3 2.472E-2
1.258E-1
 2 69
35 GO:0045670 regulation of osteoclast differentiation 3.142E-4 4.019E-3 2.686E-2
1.408E-1
 2 73
36 GO:0043299 leukocyte degranulation 3.229E-4 4.019E-3 2.686E-2
1.447E-1
 2 74
37 GO:0046486 glycerolipid metabolic process 3.397E-4 4.019E-3 2.686E-2
1.522E-1
 3 407
38 GO:0006874 cellular calcium ion homeostasis 3.496E-4 4.019E-3 2.686E-2
1.566E-1
 3 411
39 GO:0034103 regulation of tissue remodeling 3.588E-4 4.019E-3 2.686E-2
1.607E-1
 2 78
40 GO:0002683 negative regulation of immune system process 3.726E-4 4.019E-3 2.686E-2
1.669E-1
 3 420
41 GO:0002721 regulation of B cell cytokine production 3.759E-4 4.019E-3 2.686E-2
1.684E-1
 1 1
42 GO:0002275 myeloid cell activation involved in immune response 3.774E-4 4.019E-3 2.686E-2
1.691E-1
 2 80
43 GO:0055074 calcium ion homeostasis 3.858E-4 4.019E-3 2.686E-2
1.728E-1
 3 425
44 GO:0072503 cellular divalent inorganic cation homeostasis 4.131E-4 4.206E-3 2.811E-2
1.851E-1
 3 435
45 GO:0051249 regulation of lymphocyte activation 4.416E-4 4.346E-3 2.904E-2
1.978E-1
 3 445
46 GO:0060191 regulation of lipase activity 4.462E-4 4.346E-3 2.904E-2
1.999E-1
 2 87
47 GO:0072507 divalent inorganic cation homeostasis 4.805E-4 4.401E-3 2.942E-2
2.152E-1
 3 458
48 GO:1902106 negative regulation of leukocyte differentiation 4.881E-4 4.401E-3 2.942E-2
2.187E-1
 2 91
49 GO:0002444 myeloid leukocyte mediated immunity 4.988E-4 4.401E-3 2.942E-2
2.235E-1
 2 92
50 GO:0002757 immune response-activating signal transduction 5.087E-4 4.401E-3 2.942E-2
2.279E-1
 3 467
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 25 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031680 G-protein beta/gamma-subunit complex 7.344E-4 1.836E-2
7.006E-2
 1.836E-2 1 2

4: Human Phenotype [Display Chart] 2 input genes in category / 130 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001412 Enteroviral hepatitis 4.249E-4 2.762E-2
1.505E-1
5.524E-2
 1 1
2 HP:0003729 Enteroviral dermatomyositis syndrome 4.249E-4 2.762E-2
1.505E-1
5.524E-2
 1 1

5: Mouse Phenotype [Display Chart] 7 input genes in category / 542 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0009549 decreased platelet aggregation 6.993E-8 3.790E-5 2.605E-4 3.790E-5 4 71
2 MP:0009548 abnormal platelet aggregation 2.001E-7 4.478E-5 3.078E-4 1.085E-4 4 92
3 MP:0006298 abnormal platelet activation 2.479E-7 4.478E-5 3.078E-4 1.343E-4 4 97
4 MP:0009449 increased platelet ATP level 3.917E-7 5.308E-5 3.648E-4 2.123E-4 2 2
5 MP:0005464 abnormal platelet physiology 7.341E-7 7.958E-5 5.470E-4 3.979E-4 4 127
6 MP:0002463 abnormal neutrophil physiology 2.902E-6 2.622E-4 1.802E-3 1.573E-3 4 179
7 MP:0004865 abnormal platelet calcium level 1.095E-5 7.417E-4 5.098E-3 5.933E-3 2 8
8 MP:0004867 decreased platelet calcium level 1.095E-5 7.417E-4 5.098E-3 5.933E-3 2 8
9 MP:0002462 abnormal granulocyte physiology 1.320E-5 7.952E-4 5.466E-3 7.157E-3 4 262
10 MP:0002551 abnormal blood coagulation 1.742E-5 8.828E-4 6.068E-3 9.442E-3 4 281
11 MP:0009676 abnormal hemostasis 1.792E-5 8.828E-4 6.068E-3 9.710E-3 4 283
12 MP:0002461 increased immunoglobulin level 3.094E-5 1.397E-3 9.605E-3 1.677E-2 4 325
13 MP:0000726 absent lymphocyte 3.643E-5 1.519E-3 1.044E-2 1.975E-2 3 107
14 MP:0009447 abnormal platelet ATP level 4.096E-5 1.586E-3 1.090E-2 2.220E-2 2 15
15 MP:0001212 skin lesions 7.795E-5 2.817E-3 1.936E-2 4.225E-2 3 138
16 MP:0008522 abnormal lymph node germinal center morphology 1.689E-4 5.384E-3 3.701E-2
9.153E-2
 2 30
17 MP:0004721 abnormal platelet dense granule morphology 1.689E-4 5.384E-3 3.701E-2
9.153E-2
 2 30
18 MP:0002346 abnormal lymph node secondary follicle morphology 1.924E-4 5.794E-3 3.983E-2
1.043E-1
 2 32
19 MP:0004231 abnormal calcium ion homeostasis 2.381E-4 6.792E-3 4.668E-2
1.290E-1
 3 201
20 MP:0001209 spontaneous skin ulceration 2.722E-4 7.377E-3
5.070E-2
1.475E-1
 2 38
21 MP:0002344 abnormal lymph node B cell domain morphology 5.513E-4 1.423E-2
9.779E-2
2.988E-1
 2 54
22 MP:0008212 absent mature B cells 6.142E-4 1.513E-2
1.040E-1
3.329E-1
 2 57
23 MP:0013346 increased melanotroph apoptosis 6.760E-4 1.527E-2
1.049E-1
3.664E-1
 1 1
24 MP:0013347 increased corticotroph apoptosis 6.760E-4 1.527E-2
1.049E-1
3.664E-1
 1 1
25 MP:0002343 abnormal lymph node cortex morphology 7.502E-4 1.626E-2
1.118E-1
4.066E-1
 2 63
26 MP:0008071 absent B cells 1.006E-3 2.097E-2
1.442E-1
5.453E-1
 2 73
27 MP:0004984 increased osteoclast cell number 1.148E-3 2.220E-2
1.526E-1
6.222E-1
 2 78
28 MP:0002023 increased B cell derived lymphoma incidence 1.207E-3 2.220E-2
1.526E-1
6.543E-1
 2 80
29 MP:0013596 abnormal vomeronasal organ physiology 1.352E-3 2.220E-2
1.526E-1
7.326E-1
 1 2
30 MP:0013344 increased pituitary gland apoptosis 1.352E-3 2.220E-2
1.526E-1
7.326E-1
 1 2
31 MP:0013343 abnormal pituitary gland apoptosis 1.352E-3 2.220E-2
1.526E-1
7.326E-1
 1 2
32 MP:0011678 abnormal vomeronasal sensory neuron physiology 1.352E-3 2.220E-2
1.526E-1
7.326E-1
 1 2
33 MP:0008324 abnormal melanotroph morphology 1.352E-3 2.220E-2
1.526E-1
7.326E-1
 1 2
34 MP:0008396 abnormal osteoclast differentiation 1.593E-3 2.539E-2
1.745E-1
8.633E-1
 2 92
35 MP:0004720 abnormal platelet morphology 1.757E-3 2.721E-2
1.870E-1
9.524E-1
 3 398
36 MP:0010876 decreased bone volume 1.954E-3 2.817E-2
1.936E-1
1.000E0
 2 102
37 MP:0008460 absent dorsal root ganglion 2.027E-3 2.817E-2
1.936E-1
1.000E0
 1 3
38 MP:0008341 decreased corticotroph cell number 2.027E-3 2.817E-2
1.936E-1
1.000E0
 1 3
39 MP:0006048 pulmonary valve regurgitation 2.027E-3 2.817E-2
1.936E-1
1.000E0
 1 3
40 MP:0002339 abnormal lymph node morphology 2.167E-3 2.823E-2
1.940E-1
1.000E0
 3 428
41 MP:0009345 abnormal trabecular bone thickness 2.187E-3 2.823E-2
1.940E-1
1.000E0
 2 108
42 MP:0010563 increased heart right ventricle size 2.187E-3 2.823E-2
1.940E-1
1.000E0
 2 108
43 MP:0005432 abnormal pro-B cell morphology 2.350E-3 2.962E-2
2.036E-1
1.000E0
 2 112
44 MP:0009318 increased splenic marginal zone lymphoma incidence 2.702E-3 3.328E-2
2.287E-1
1.000E0
 1 4
45 MP:0010577 abnormal heart right ventricle size 3.104E-3 3.588E-2
2.466E-1
1.000E0
 2 129
46 MP:0003109 short femur 3.152E-3 3.588E-2
2.466E-1
1.000E0
 2 130
47 MP:0030825 decreased femur size 3.296E-3 3.588E-2
2.466E-1
1.000E0
 2 133
48 MP:0002403 abnormal pre-B cell morphology 3.296E-3 3.588E-2
2.466E-1
1.000E0
 2 133
49 MP:0004983 abnormal osteoclast cell number 3.345E-3 3.588E-2
2.466E-1
1.000E0
 2 134
50 MP:0004210 abnormal bitter taste sensitivity 3.376E-3 3.588E-2
2.466E-1
1.000E0
 1 5
Show 45 more annotations

6: Domain [Display Chart] 7 input genes in category / 80 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR001192 PI-PLC fam InterPro 1.450E-8 1.658E-7 8.231E-7 1.160E-6 3 15
2 PS50008 PIPLC Y DOMAIN PROSITE 1.450E-8 1.658E-7 8.231E-7 1.160E-6 3 15
3 SM00149 PLCYc SMART 1.450E-8 1.658E-7 8.231E-7 1.160E-6 3 15
4 PF09279 EF-hand like Pfam 1.450E-8 1.658E-7 8.231E-7 1.160E-6 3 15
5 IPR015359 PLC EF-hand-like InterPro 1.450E-8 1.658E-7 8.231E-7 1.160E-6 3 15
6 IPR001711 PLipase C Pinositol-sp Y InterPro 1.450E-8 1.658E-7 8.231E-7 1.160E-6 3 15
7 PF00387 PI-PLC-Y Pfam 1.450E-8 1.658E-7 8.231E-7 1.160E-6 3 15
8 PF00388 PI-PLC-X Pfam 2.600E-8 2.245E-7 1.115E-6 2.080E-6 3 18
9 SM00148 PLCXc SMART 2.600E-8 2.245E-7 1.115E-6 2.080E-6 3 18
10 IPR000909 PLipase C PInositol-sp X dom InterPro 3.087E-8 2.245E-7 1.115E-6 2.470E-6 3 19
11 PS50007 PIPLC X DOMAIN PROSITE 3.087E-8 2.245E-7 1.115E-6 2.470E-6 3 19
12 3.20.20.190 - Gene3D 7.320E-8 4.505E-7 2.237E-6 5.856E-6 3 25
13 IPR017946 PLC-like Pdiesterase TIM-brl InterPro 7.320E-8 4.505E-7 2.237E-6 5.856E-6 3 25
14 PS50004 C2 PROSITE 1.088E-7 6.216E-7 3.086E-6 8.702E-6 4 142
15 IPR011993 PH dom-like InterPro 1.215E-7 6.424E-7 3.190E-6 9.722E-6 5 427
16 2.60.40.150 - Gene3D 1.285E-7 6.424E-7 3.190E-6 1.028E-5 4 148
17 IPR000008 C2 dom InterPro 1.941E-7 9.134E-7 4.536E-6 1.553E-5 4 164
18 PF08703 PLC-beta C Pfam 3.589E-7 1.511E-6 7.504E-6 2.871E-5 2 3
19 IPR014815 PLC-beta C InterPro 3.589E-7 1.511E-6 7.504E-6 2.871E-5 2 3
20 IPR016280 PLC-beta InterPro 7.177E-7 2.871E-6 1.426E-5 5.742E-5 2 4
21 2.30.29.30 - Gene3D 6.222E-6 2.370E-5 1.177E-4 4.977E-4 4 391
22 PF00168 C2 Pfam 1.146E-5 4.166E-5 2.069E-4 9.165E-4 3 131
23 SM00239 C2 SMART 1.310E-5 4.558E-5 2.263E-4 1.048E-3 3 137
24 1.10.238.10 - Gene3D 8.976E-5 2.992E-4 1.486E-3 7.181E-3 3 261
25 IPR011992 EF-hand-dom pair InterPro 1.190E-4 3.807E-4 1.890E-3 9.517E-3 3 287
26 IPR033931 PDK1-typ PH InterPro 3.736E-4 9.964E-4 4.947E-3 2.989E-2 1 1
27 IPR028398 PLC-epsilon1 InterPro 3.736E-4 9.964E-4 4.947E-3 2.989E-2 1 1
28 IPR028390 PLC-beta3 InterPro 3.736E-4 9.964E-4 4.947E-3 2.989E-2 1 1
29 IPR028403 PLC-beta2 InterPro 3.736E-4 9.964E-4 4.947E-3 2.989E-2 1 1
30 PF14593 PH 3 Pfam 3.736E-4 9.964E-4 4.947E-3 2.989E-2 1 1
31 PF00017 SH2 Pfam 5.937E-4 1.532E-3 7.608E-3 4.750E-2 2 101
32 SM00252 SH2 SMART 7.037E-4 1.667E-3 8.278E-3
5.630E-2
 2 110
33 PS50001 SH2 PROSITE 7.165E-4 1.667E-3 8.278E-3
5.732E-2
 2 111
34 IPR000980 SH2 InterPro 7.294E-4 1.667E-3 8.278E-3
5.835E-2
 2 112
35 3.30.505.10 - Gene3D 7.294E-4 1.667E-3 8.278E-3
5.835E-2
 2 112
36 PF06631 DUF1154 Pfam 1.121E-3 2.423E-3 1.203E-2
8.964E-2
 1 3
37 IPR009535 PLC-beta CS InterPro 1.121E-3 2.423E-3 1.203E-2
8.964E-2
 1 3
38 SM00107 BTK SMART 3.358E-3 6.553E-3 3.254E-2
2.687E-1
 1 9
39 PF00779 BTK Pfam 3.358E-3 6.553E-3 3.254E-2
2.687E-1
 1 9
40 IPR001562 Znf Btk motif InterPro 3.358E-3 6.553E-3 3.254E-2
2.687E-1
 1 9
41 PS51113 ZF BTK PROSITE 3.358E-3 6.553E-3 3.254E-2
2.687E-1
 1 9
42 IPR000300 IPPc InterPro 3.731E-3 6.941E-3 3.447E-2
2.985E-1
 1 10
43 SM00128 IPPc SMART 3.731E-3 6.941E-3 3.447E-2
2.985E-1
 1 10
44 PS50003 PH DOMAIN PROSITE 4.448E-3 7.963E-3 3.954E-2
3.558E-1
 2 280
45 IPR001849 PH domain InterPro 4.479E-3 7.963E-3 3.954E-2
3.583E-1
 2 281
46 IPR017441 Protein kinase ATP BS InterPro 8.014E-3 1.394E-2
6.920E-2
6.411E-1
 2 379
47 3.60.10.10 - Gene3D 9.676E-3 1.580E-2
7.844E-2
7.741E-1
 1 26
48 PF03372 Exo endo phos Pfam 9.676E-3 1.580E-2
7.844E-2
7.741E-1
 1 26
49 PS00720 RASGEF PROSITE 9.676E-3 1.580E-2
7.844E-2
7.741E-1
 1 26
50 IPR005135 Endo/exonuclease/phosphatase InterPro 1.005E-2 1.594E-2
7.914E-2
8.037E-1
 1 27
Show 45 more annotations

7: Pathway [Display Chart] 7 input genes in category / 273 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269988 Inositol phosphate metabolism BioSystems: REACTOME 1.286E-11 3.511E-9 2.173E-8 3.511E-9 5 47
2 82987 Inositol phosphate metabolism BioSystems: KEGG 1.088E-10 1.485E-8 9.191E-8 2.970E-8 5 71
3 83052 Phosphatidylinositol signaling system BioSystems: KEGG 5.367E-10 4.865E-8 3.011E-7 1.465E-7 5 97
4 1269989 Synthesis of IP3 and IP4 in the cytosol BioSystems: REACTOME 7.129E-10 4.865E-8 3.011E-7 1.946E-7 4 28
5 PW:0000232 phosphatidylinositol 3-kinase-Akt signaling Pathway Ontology 1.613E-9 8.806E-8 5.450E-7 4.403E-7 4 34
6 547492 superpathway of inositol phosphate compounds BioSystems: BIOCYC 2.491E-8 1.133E-6 7.014E-6 6.800E-6 4 66
7 545315 D-myo-inositol-5-phosphate metabolism BioSystems: BIOCYC 7.377E-8 2.877E-6 1.780E-5 2.014E-5 3 17
8 P00002 Alpha adrenergic receptor signaling pathway PantherDB 1.441E-7 4.919E-6 3.044E-5 3.935E-5 3 21
9 413400 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 BioSystems: KEGG 1.669E-7 5.061E-6 3.132E-5 4.555E-5 3 22
10 545326 D-myo-inositol (1,4,5)-trisphosphate biosynthesis BioSystems: BIOCYC 1.918E-7 5.237E-6 3.241E-5 5.237E-5 3 23
11 946598 Thyroid hormone signaling pathway BioSystems: KEGG 2.451E-7 6.083E-6 3.764E-5 6.691E-5 4 116
12 142419 phospholipases BioSystems: BIOCYC 3.952E-7 8.992E-6 5.565E-5 1.079E-4 3 29
13 M14532 PI3K Pathway MSigDB C2 BIOCARTA (v6.0) 8.388E-7 1.762E-5 1.090E-4 2.290E-4 3 37
14 P04385 Histamine H1 receptor mediated signaling pathway PantherDB 1.238E-6 2.414E-5 1.494E-4 3.379E-4 3 42
15 M8626 Members of the BCR signaling pathway MSigDB C2 BIOCARTA (v6.0) 1.635E-6 2.976E-5 1.842E-4 4.464E-4 3 46
16 P00031 Inflammation mediated by chemokine and cytokine signaling pathway PantherDB 1.812E-6 3.092E-5 1.914E-4 4.948E-4 4 191
17 1269580 G-protein beta:gamma signalling BioSystems: REACTOME 2.241E-6 3.598E-5 2.227E-4 6.117E-4 3 51
18 P04391 Oxytocin receptor mediated signaling pathway PantherDB 2.820E-6 4.277E-5 2.647E-4 7.699E-4 3 55
19 P04394 Thyrotropin-releasing hormone receptor signaling pathway PantherDB 3.314E-6 4.762E-5 2.947E-4 9.048E-4 3 58
20 P05726 2-arachidonoylglycerol biosynthesis PantherDB 4.060E-6 5.538E-5 3.427E-4 1.108E-3 2 6
21 P04374 5HT2 type receptor mediated signaling pathway PantherDB 4.260E-6 5.538E-5 3.427E-4 1.163E-3 3 63
22 83082 Fc epsilon RI signaling pathway BioSystems: KEGG 5.370E-6 6.664E-5 4.124E-4 1.466E-3 3 68
23 137910 CXCR4-mediated signaling events BioSystems: Pathway Interaction Database 7.518E-6 8.272E-5 5.119E-4 2.052E-3 3 76
24 1270106 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion BioSystems: REACTOME 7.575E-6 8.272E-5 5.119E-4 2.068E-3 2 8
25 1270105 Free fatty acids regulate insulin secretion BioSystems: REACTOME 7.575E-6 8.272E-5 5.119E-4 2.068E-3 2 8
26 1270104 Acetylcholine regulates insulin secretion BioSystems: REACTOME 1.217E-5 1.278E-4 7.907E-4 3.322E-3 2 10
27 1319988 AGE-RAGE signaling pathway in diabetic complications BioSystems: KEGG 1.668E-5 1.687E-4 1.044E-3 4.554E-3 3 99
28 1144995 Sphingolipid signaling pathway BioSystems: KEGG 2.826E-5 2.755E-4 1.705E-3 7.714E-3 3 118
29 952858 Platelet activation BioSystems: KEGG 3.200E-5 3.012E-4 1.864E-3 8.735E-3 3 123
30 MAP00562 Inositol phosphate metabolism MAP00562 Inositol phosphate metabolism GenMAPP 4.613E-5 4.198E-4 2.598E-3 1.259E-2 2 19
31 545349 3-phosphoinositide degradation BioSystems: BIOCYC 5.124E-5 4.371E-4 2.705E-3 1.399E-2 2 20
32 1269582 G beta:gamma signalling through PLC beta BioSystems: REACTOME 5.124E-5 4.371E-4 2.705E-3 1.399E-2 2 20
33 1268786 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell BioSystems: REACTOME 5.452E-5 4.510E-4 2.791E-3 1.488E-2 3 147
34 1268812 Presynaptic function of Kainate receptors BioSystems: REACTOME 5.662E-5 4.546E-4 2.813E-3 1.546E-2 2 21
35 PW:0000154 inositol phosphate metabolic Pathway Ontology 6.226E-5 4.857E-4 3.005E-3 1.700E-2 2 22
36 M8809 Phosphoinositides and their downstream targets. MSigDB C2 BIOCARTA (v6.0) 6.817E-5 5.170E-4 3.199E-3 1.861E-2 2 23
37 P05730 Endogenous cannabinoid signaling PantherDB 7.435E-5 5.486E-4 3.395E-3 2.030E-2 2 24
38 138009 Plasma membrane estrogen receptor signaling BioSystems: Pathway Interaction Database 8.751E-5 6.287E-4 3.890E-3 2.389E-2 2 26
39 83050 Calcium signaling pathway BioSystems: KEGG 1.030E-4 7.211E-4 4.462E-3 2.812E-2 3 182
40 1268808 Activation of Kainate Receptors upon glutamate binding BioSystems: REACTOME 1.333E-4 9.100E-4 5.632E-3 3.640E-2 2 32
41 PW:0000008 Wnt signaling Pathway Ontology 1.419E-4 9.448E-4 5.847E-3 3.874E-2 2 33
42 868086 Rap1 signaling pathway BioSystems: KEGG 1.575E-4 9.485E-4 5.870E-3 4.300E-2 3 210
43 P05911 Angiotensin II-stimulated signaling through G proteins and beta-arrestin PantherDB 1.598E-4 9.485E-4 5.870E-3 4.363E-2 2 35
44 138081 FAS (CD95) signaling pathway BioSystems: Pathway Interaction Database 1.598E-4 9.485E-4 5.870E-3 4.363E-2 2 35
45 194384 African trypanosomiasis BioSystems: KEGG 1.598E-4 9.485E-4 5.870E-3 4.363E-2 2 35
46 M18342 G alpha i Pathway MSigDB C2 BIOCARTA (v6.0) 1.598E-4 9.485E-4 5.870E-3 4.363E-2 2 35
47 M1315 Genes related to PIP3 signaling in B lymphocytes MSigDB C2 BIOCARTA (v6.0) 1.692E-4 9.826E-4 6.081E-3 4.618E-2 2 36
48 1268766 Transmission across Chemical Synapses BioSystems: REACTOME 1.760E-4 1.001E-3 6.193E-3 4.804E-2 3 218
49 138022 Class I PI3K signaling events BioSystems: Pathway Interaction Database 2.199E-4 1.225E-3 7.582E-3
6.003E-2
 2 41
50 M5193 Genes related to chemotaxis MSigDB C2 BIOCARTA (v6.0) 2.652E-4 1.448E-3 8.961E-3
7.240E-2
 2 45
Show 45 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 1649 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7589147 Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. Pubmed 4.521E-10 3.728E-7 2.977E-6 7.455E-7 3 10
2 10501179 Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. Pubmed 4.521E-10 3.728E-7 2.977E-6 7.455E-7 3 10
3 1979339 Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. Pubmed 3.072E-9 1.689E-6 1.349E-5 5.066E-6 3 18
4 20056178 Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. Pubmed 6.176E-9 2.039E-6 1.628E-5 1.018E-5 4 141
5 9278385 The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. Pubmed 7.617E-9 2.039E-6 1.628E-5 1.256E-5 3 24
6 9730685 HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. Pubmed 7.617E-9 2.039E-6 1.628E-5 1.256E-5 3 24
7 10843712 Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. Pubmed 8.655E-9 2.039E-6 1.628E-5 1.427E-5 3 25
8 20336759 Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade. Pubmed 1.101E-8 2.269E-6 1.812E-5 1.815E-5 3 27
9 10856225 Phosphatidylinositol 3,4,5-trisphosphate regulates Ca(2+) entry via btk in platelets and megakaryocytes without increasing phospholipase C activity. Pubmed 2.879E-8 4.748E-6 3.792E-5 4.748E-5 2 2
10 16314422 G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner. Pubmed 2.879E-8 4.748E-6 3.792E-5 4.748E-5 2 2
11 12482669 Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. Pubmed 3.435E-8 5.150E-6 4.112E-5 5.665E-5 3 39
12 15705797 The relative role of PLCbeta and PI3Kgamma in platelet activation. Pubmed 8.637E-8 9.495E-6 7.582E-5 1.424E-4 2 3
13 17675482 Phospholipase cbeta is critical for T cell chemotaxis. Pubmed 8.637E-8 9.495E-6 7.582E-5 1.424E-4 2 3
14 10748023 Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2. Pubmed 8.637E-8 9.495E-6 7.582E-5 1.424E-4 2 3
15 18079968 Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. Pubmed 8.637E-8 9.495E-6 7.582E-5 1.424E-4 2 3
16 9305844 Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Pubmed 1.727E-7 1.187E-5 9.477E-5 2.848E-4 2 4
17 23006664 PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq. Pubmed 1.727E-7 1.187E-5 9.477E-5 2.848E-4 2 4
18 24223520 N-wasp is essential for the negative regulation of B cell receptor signaling. Pubmed 1.727E-7 1.187E-5 9.477E-5 2.848E-4 2 4
19 12874264 Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone. Pubmed 1.727E-7 1.187E-5 9.477E-5 2.848E-4 2 4
20 9753089 Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain. Pubmed 1.727E-7 1.187E-5 9.477E-5 2.848E-4 2 4
21 15174099 Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation. Pubmed 1.727E-7 1.187E-5 9.477E-5 2.848E-4 2 4
22 21622861 A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling. Pubmed 1.727E-7 1.187E-5 9.477E-5 2.848E-4 2 4
23 22728827 GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. Pubmed 1.727E-7 1.187E-5 9.477E-5 2.848E-4 2 4
24 10669417 Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Pubmed 1.727E-7 1.187E-5 9.477E-5 2.848E-4 2 4
25 17921328 Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury. Pubmed 2.879E-7 1.637E-5 1.307E-4 4.747E-4 2 5
26 28821013 Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin. Pubmed 2.879E-7 1.637E-5 1.307E-4 4.747E-4 2 5
27 26468229 Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo. Pubmed 2.879E-7 1.637E-5 1.307E-4 4.747E-4 2 5
28 11941371 The TRPM7 channel is inactivated by PIP(2) hydrolysis. Pubmed 2.879E-7 1.637E-5 1.307E-4 4.747E-4 2 5
29 15611108 Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2. Pubmed 2.879E-7 1.637E-5 1.307E-4 4.747E-4 2 5
30 2841328 Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets. Pubmed 4.318E-7 2.157E-5 1.723E-4 7.120E-4 2 6
31 8739298 Expression and immunohistochemical localization of eight phospholipase C isoforms in adult male mouse cerebellar cortex. Pubmed 4.318E-7 2.157E-5 1.723E-4 7.120E-4 2 6
32 10609087 Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice. Pubmed 4.318E-7 2.157E-5 1.723E-4 7.120E-4 2 6
33 19647226 Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Pubmed 4.318E-7 2.157E-5 1.723E-4 7.120E-4 2 6
34 10829070 A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Pubmed 1.036E-6 5.024E-5 4.012E-4 1.708E-3 2 9
35 15623527 Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. Pubmed 1.295E-6 5.931E-5 4.736E-4 2.135E-3 2 10
36 2033248 Expression of phospholipase C isozymes by murine B lymphocytes. Pubmed 1.295E-6 5.931E-5 4.736E-4 2.135E-3 2 10
37 25959047 Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation. Pubmed 1.899E-6 8.462E-5 6.757E-4 3.131E-3 2 12
38 16601135 Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Pubmed 3.020E-6 1.310E-4 1.046E-3 4.980E-3 2 15
39 9560157 Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Pubmed 8.621E-6 3.645E-4 2.911E-3 1.422E-2 2 25
40 8672127 Genetic mapping of the human and mouse phospholipase C genes. Pubmed 1.516E-5 4.579E-4 3.657E-3 2.500E-2 2 33
41 15760467 Searching QTL by gene expression: analysis of diabesity. Pubmed 6.142E-5 4.579E-4 3.657E-3
1.013E-1
 2 66
42 8070818 The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c. Pubmed 1.833E-4 4.579E-4 3.657E-3
3.022E-1
 1 1
43 10567711 Potential role of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in insulin-stimulated glucose transporter 4 translocation in adipocytes. Pubmed 1.833E-4 4.579E-4 3.657E-3
3.022E-1
 1 1
44 2881637 Genetic heterogeneity in X-linked agammaglobulinemia complicates carrier detection and prenatal diagnosis. Pubmed 1.833E-4 4.579E-4 3.657E-3
3.022E-1
 1 1
45 27318090 INPP4B reverses docetaxel resistance and epithelial-to-mesenchymal transition via the PI3K/Akt signaling pathway in prostate cancer. Pubmed 1.833E-4 4.579E-4 3.657E-3
3.022E-1
 1 1
46 24307874 Molecular dynamic simulation to explore the molecular basis of Btk-PH domain interaction with Ins(1,3,4,5)P4. Pubmed 1.833E-4 4.579E-4 3.657E-3
3.022E-1
 1 1
47 25726712 PDK1 is a potential therapeutic target against angiosarcoma cells. Pubmed 1.833E-4 4.579E-4 3.657E-3
3.022E-1
 1 1
48 7612006 Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene. Pubmed 1.833E-4 4.579E-4 3.657E-3
3.022E-1
 1 1
49 21487159 INPP4B: the new kid on the PI3K block. Pubmed 1.833E-4 4.579E-4 3.657E-3
3.022E-1
 1 1
50 16247441 Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene. Pubmed 1.833E-4 4.579E-4 3.657E-3
3.022E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 267 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:KIT KIT interactions 2.629E-6 5.281E-4 3.257E-3 7.018E-4 3 76
2 int:SLC9A3R2 SLC9A3R2 interactions 3.956E-6 5.281E-4 3.257E-3 1.056E-3 3 87
3 int:TRPM7 TRPM7 interactions 3.084E-5 2.254E-3 1.390E-2 8.235E-3 2 22
4 int:TRPC3 TRPC3 interactions 3.377E-5 2.254E-3 1.390E-2 9.018E-3 2 23
5 int:PRKCQ PRKCQ interactions 1.316E-4 7.028E-3 4.334E-2 3.514E-2 2 45
6 int:INPP5D INPP5D interactions 3.287E-4 1.463E-2
9.021E-2
8.777E-2
 2 71
7 int:RPS6KB1 RPS6KB1 interactions 4.710E-4 1.636E-2
1.009E-1
1.258E-1
 2 85
8 int:PRKCE PRKCE interactions 4.934E-4 1.636E-2
1.009E-1
1.317E-1
 2 87
9 int:HCK HCK interactions 5.516E-4 1.636E-2
1.009E-1
1.473E-1
 2 92
10 int:GNAQ GNAQ interactions 6.513E-4 1.739E-2
1.072E-1
1.739E-1
 2 100
11 int:BTK BTK interactions 7.873E-4 1.911E-2
1.178E-1
2.102E-1
 2 110
12 int:JAK1 JAK1 interactions 9.671E-4 1.986E-2
1.225E-1
2.582E-1
 2 122
13 int:PRKCB PRKCB interactions 9.671E-4 1.986E-2
1.225E-1
2.582E-1
 2 122
14 int:TLR8 TLR8 interactions 1.186E-3 2.061E-2
1.271E-1
3.166E-1
 1 3
15 int:CLYBL CLYBL interactions 1.186E-3 2.061E-2
1.271E-1
3.166E-1
 1 3
16 int:SYK SYK interactions 1.235E-3 2.061E-2
1.271E-1
3.297E-1
 2 138
17 int:INPP4B INPP4B interactions 1.581E-3 2.483E-2
1.531E-1
4.221E-1
 1 4
18 int:PLCG1 PLCG1 interactions 1.822E-3 2.512E-2
1.549E-1
4.865E-1
 2 168
19 int:PRKCD PRKCD interactions 1.844E-3 2.512E-2
1.549E-1
4.922E-1
 2 169
20 int:CD300LF CD300LF interactions 1.976E-3 2.512E-2
1.549E-1
5.275E-1
 1 5
21 int:PIP5K1B PIP5K1B interactions 1.976E-3 2.512E-2
1.549E-1
5.275E-1
 1 5
22 int:CD300A CD300A interactions 2.370E-3 2.752E-2
1.697E-1
6.329E-1
 1 6
23 int:TLR6 TLR6 interactions 2.370E-3 2.752E-2
1.697E-1
6.329E-1
 1 6
24 int:RPS6KB2 RPS6KB2 interactions 2.569E-3 2.858E-2
1.763E-1
6.860E-1
 2 200
25 int:PRKCZ PRKCZ interactions 3.126E-3 3.115E-2
1.921E-1
8.347E-1
 2 221
26 int:PLCE1 PLCE1 interactions 3.160E-3 3.115E-2
1.921E-1
8.436E-1
 1 8
27 int:PRXL2B PRXL2B interactions 3.160E-3 3.115E-2
1.921E-1
8.436E-1
 1 8
28 int:ABL1 ABL1 interactions 3.266E-3 3.115E-2
1.921E-1
8.722E-1
 2 226
29 int:LYN LYN interactions 3.439E-3 3.163E-2
1.950E-1
9.181E-1
 2 232
30 int:ANKRD54 ANKRD54 interactions 3.554E-3 3.163E-2
1.950E-1
9.489E-1
 1 9
31 int:ZDHHC17 ZDHHC17 interactions 3.857E-3 3.220E-2
1.986E-1
1.000E0
 2 246
32 int:PIK3AP1 PIK3AP1 interactions 3.948E-3 3.220E-2
1.986E-1
1.000E0
 1 10
33 int:LPAR2 LPAR2 interactions 4.342E-3 3.220E-2
1.986E-1
1.000E0
 1 11
34 int:FAM199X FAM199X interactions 4.342E-3 3.220E-2
1.986E-1
1.000E0
 1 11
35 int:CMTM3 CMTM3 interactions 4.342E-3 3.220E-2
1.986E-1
1.000E0
 1 11
36 int:KATNBL1 KATNBL1 interactions 4.342E-3 3.220E-2
1.986E-1
1.000E0
 1 11
37 int:CBL CBL interactions 4.660E-3 3.328E-2
2.052E-1
1.000E0
 2 271
38 int:MPP7 MPP7 interactions 4.736E-3 3.328E-2
2.052E-1
1.000E0
 1 12
39 int:PRKG2 PRKG2 interactions 5.130E-3 3.512E-2
2.166E-1
1.000E0
 1 13
40 int:PLCB2 PLCB2 interactions 5.524E-3 3.597E-2
2.218E-1
1.000E0
 1 14
41 int:CDAN1 CDAN1 interactions 5.524E-3 3.597E-2
2.218E-1
1.000E0
 1 14
42 int:SGK3 SGK3 interactions 5.917E-3 3.703E-2
2.284E-1
1.000E0
 1 15
43 int:SCRN2 SCRN2 interactions 6.311E-3 3.703E-2
2.284E-1
1.000E0
 1 16
44 int:LILRB4 LILRB4 interactions 6.311E-3 3.703E-2
2.284E-1
1.000E0
 1 16
45 int:DDIT4 DDIT4 interactions 6.311E-3 3.703E-2
2.284E-1
1.000E0
 1 16
46 int:NAA16 NAA16 interactions 7.097E-3 3.703E-2
2.284E-1
1.000E0
 1 18
47 int:KATNB1 KATNB1 interactions 7.097E-3 3.703E-2
2.284E-1
1.000E0
 1 18
48 int:SERPINA4 SERPINA4 interactions 7.097E-3 3.703E-2
2.284E-1
1.000E0
 1 18
49 int:MYLK2 MYLK2 interactions 7.490E-3 3.703E-2
2.284E-1
1.000E0
 1 19
50 int:POTEKP POTEKP interactions 7.490E-3 3.703E-2
2.284E-1
1.000E0
 1 19
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Xq21.33-q22 Xq21.33-q22 2.020E-4 1.414E-3 3.666E-3 1.414E-3 1 1
2 15q15 15q15 2.421E-3 6.120E-3 1.587E-2 1.695E-2 1 12
3 10q23 10q23 2.623E-3 6.120E-3 1.587E-2 1.836E-2 1 13
4 4q31.21 4q31.21 5.441E-3 9.521E-3 2.469E-2 3.808E-2 1 27
5 2q37.1 2q37.1 1.365E-2 1.912E-2 4.956E-2
9.558E-2
 1 68
6 11q13 11q13 2.379E-2 2.775E-2
7.196E-2
1.665E-1
 1 119
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 87 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 832 Phospholipases|C2 domain containing phospholipases genenames.org 1.927E-8 1.156E-7 2.833E-7 1.156E-7 3 19
2 467 Phospholipases genenames.org 2.277E-7 6.830E-7 1.673E-6 1.366E-6 3 42
3 1079 Atypical dual specificity phosphatases|Phosphoinositide phosphatases genenames.org 4.476E-5 8.951E-5 2.193E-4 2.685E-4 2 32
4 741 SH2 domain containing genenames.org 4.511E-4 6.766E-4 1.658E-3 2.707E-3 2 101
5 823 C2 domain containing|Calpains genenames.org 1.182E-2 1.418E-2 3.474E-2
7.089E-2
 1 36

13: Coexpression [Display Chart] 7 input genes in category / 806 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M4458 Genes up-regulated in comparison of monocytes cultured for 0 days versus those cultured for 1 day. MSigDB C7: Immunologic Signatures (v6.0) 2.171E-5 1.106E-2
8.040E-2
 1.750E-2 3 200
2 12925741-Figure11 Human Lymphoma Jenner03 44genes GeneSigDB 2.744E-5 1.106E-2
8.040E-2
 2.212E-2 2 27
3 18410693-TableS7 Human Leukemia Kiiveri08 100genes T-ALLTree GeneSigDB 1.719E-4 2.659E-2
1.933E-1
1.385E-1
 2 67
4 18410693-TableS13 Human Leukemia Kiiveri08 100genes T-ALLParallel GeneSigDB 1.770E-4 2.659E-2
1.933E-1
1.427E-1
 2 68
5 19204596-Table4 Human Muscle Stepto09 102genes GeneSigDB 3.678E-4 2.659E-2
1.933E-1
2.964E-1
 2 98
6 M6590 The 'NPM1-mutated signature 2': genes up-regulated in pediatric AML (acute myeloid leukemia) samples with mutated NPM1 [GeneID=4869] compared to the AML cases with the intact gene and without recurring cytogenetic anomalities or M7 phenotype. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.378E-4 2.659E-2
1.933E-1
5.947E-1
 2 139
7 M2859 Genes down-regulated in epithelial lung cancer cell lines over-expressing KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 7.806E-4 2.659E-2
1.933E-1
6.291E-1
 2 143
8 M369 Genes down-regulated in macrophages differentiated for 5 days in the presence of: IL4 [GeneID=3565] versus IL4 [GeneID=3565] and dexamethasone [PubChem=5743]. MSigDB C7: Immunologic Signatures (v6.0) 8.024E-4 2.659E-2
1.933E-1
6.467E-1
 2 145
9 M7722 Genes up-regulated in bone marrow-derived dendritic cellstreated by poly(IC): 3h versus 24h. MSigDB C7: Immunologic Signatures (v6.0) 9.635E-4 2.659E-2
1.933E-1
7.766E-1
 2 159
10 M6332 Genes up-regulated in spleen from mice injected with LPS: DUSP1 [GeneID=1843] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 9.999E-4 2.659E-2
1.933E-1
8.059E-1
 2 162
11 M8182 Genes down-regulated in B lymphocytes immunized with: imiquimod [PubChem=13982876] versus monophosphoryl lipid A and imiquimod [PubChem=13982876]. MSigDB C7: Immunologic Signatures (v6.0) 9.999E-4 2.659E-2
1.933E-1
8.059E-1
 2 162
12 M6084 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (2h) versus TGFB1 [GeneID=7040] and IL-12 (2h). MSigDB C7: Immunologic Signatures (v6.0) 1.012E-3 2.659E-2
1.933E-1
8.158E-1
 2 163
13 M8120 Genes up-regulated in IL10 and NFKB1 [GeneID=4790;3586] knockout macrophages: unstimulated versus stimulated by IL10 [GeneID=3586] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.037E-3 2.659E-2
1.933E-1
8.357E-1
 2 165
14 M6340 Genes up-regulated in Vd2 gamma delta T cells: untreated versus phorbol myristate acetate and ionomycin [PubChem=4792;3733]. MSigDB C7: Immunologic Signatures (v6.0) 1.139E-3 2.659E-2
1.933E-1
9.180E-1
 2 173
15 17009876-tableS3a Mouse StemCell Ramos06 206genes GeneSigDB 1.165E-3 2.659E-2
1.933E-1
9.391E-1
 2 175
16 M5354 Genes required for proliferation of DLD-1 cell (colon cancer with APC [GeneID=324] deletions), based on shRNA screen. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.165E-3 2.659E-2
1.933E-1
9.391E-1
 2 175
17 M2686 Genes up-regulated in myometrial cells over-expressing ATF2 [Gene ID=1386] gene. MSigDB C6: Oncogenic Signatures (v6.0) 1.371E-3 2.659E-2
1.933E-1
1.000E0
 2 190
18 M9305 Genes up-regulated in CD4 [GeneID=920]: naïve versus FOXP3+ [GeneID=50943] T reg. MSigDB C7: Immunologic Signatures (v6.0) 1.414E-3 2.659E-2
1.933E-1
1.000E0
 2 193
19 M8422 Genes down-regulated in lin- cells: TCF7 [GeneID=6932] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.659E-2
1.933E-1
1.000E0
 2 199
20 M5249 Genes down-regulated in comparison of macrophages exposed to L. major versus macrophages exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.659E-2
1.933E-1
1.000E0
 2 199
21 M7679 Genes down-regulated in the in vitro follicular dendritic cells from peripheral lymph nodes (96h): tretinoin [PubChem=444795] versus tretinoin [PubChem=444795] and Pam2CSK4. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.659E-2
1.933E-1
1.000E0
 2 199
22 M8424 Genes down-regulated in B lymphocytes: systemic lupus erythematosous (SLE) versus healthy. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.659E-2
1.933E-1
1.000E0
 2 199
23 M9701 Genes down-regulated in macrophage differentiated by: CSF1 [GeneID=1435] versus CSF1 [GeneID=1435] and IL27 [GeneID=246778]. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.659E-2
1.933E-1
1.000E0
 2 199
24 M3255 Genes down-regulated in comparison of plasma cells versus memory B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
25 M8653 Genes up-regulated in P14 CD8+ T cells: ST2 [GeneID=6761] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
26 M8100 Genes down-regulated in NFKB1 and IL10 [GeneID=4790;3586] knockout macrophages stimulated by LPS versus those also stimulated by IL10 [GeneID=3586]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
27 M3908 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 1 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
28 M2934 Genes up-regulated in CD8 T cells: naïve versus activated. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
29 M9594 Genes up-regulated in thymic T conv: CD24 high [GeneID=100133941] versus CD24 low [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
30 M3251 Genes up-regulated in comparison of Ig isotype switched memory B cells versus plasma cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
31 M9002 Genes down-regulated in CD4 [GeneID=920] T cells over-expressing FOXP3 [GeneID=50943] and Pparg1 isoform of PPARG [GeneID=5468]: untreated versus pioglitazone [PubChem=4829]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
32 M4898 Genes up-regulated in comparison of primary splenic B cells from wild type mice versus those from BTK [GeneID=695] knockout mice. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
33 M3175 Genes down-regulated in plasma cells versus naive B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
34 M4318 Genes down-regulated in comparison of TregLP versus DEC-Pept Convert (see Table 1S in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
35 M9168 Genes down-regulated in CD4 T conv over-expressing IKZF2 [GeneID=22807] versus IKZF2 and FOX3P [GeneID=22807;50943]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
36 M6187 Genes down-regulated in C57BL6 CD4 CD8 double positive thymocyte transgenic for the BDC2.5 TCR incubated with no peptide 0h versus NOD CD4 CD8 double positive thymocyte transgenic for the BDC2.5 TCR incubated with no peptide 0h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
37 M5977 Genes down-regulated in liver from SOCS3 [GeneID=9021] knockout: untreated versus IL6 [GeneID=3569] injection. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
38 M5187 Genes up-regulated in comparison of dendritic cells (DC) exposed to 5 worm/well B. malayi versus macrophages exposed to 5 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
39 M9041 Genes up-regulated in macrophages with knockout of HDAC3 [GeneID=8841] after LPS treatment: heterozygous versus homozygous. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
40 M3465 Genes down-regulated in comparison of CD4 [GeneID=920] CD8 thymocytes versus naive CD4 [GeneID=920] T cells from adult blood. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
41 M5151 Genes down-regulated in comparison of dendritic cells (DC) versus DCs exposed to B. malayi (50 worms/well). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
42 M4876 Genes down-regulated in comparison of erythroblasts versus neutrophils. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
43 M5154 Genes up-regulated in comparison of dendritic cells (DC) versus DCs exposed to M.tuberculosis. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
44 M7760 Genes up-regulated in macrophages: wildtype versus MYD88 [GeneID=4615] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
45 M6067 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 [GeneID=7040] and IL-12 (6h) versus untreated (6h). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
46 M7210 Genes up-regulated in mouse embryonic fibroblasts (MEF): LPS versus LPS and heat shock. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.659E-2
1.933E-1
1.000E0
 2 200
47 14768006-SuppTable4 Human Breast Kim04 273genes GeneSigDB 1.563E-3 2.680E-2
1.948E-1
1.000E0
 2 203
48 M11234 Genes down-regulated in polymorphonuclear neutrophilic granulocytes (PMNs) attracted to skin wounds. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.915E-3 3.215E-2
2.337E-1
1.000E0
 2 225
49 15501956-Table4 Human Leukemia Rodriguez04 10genes GeneSigDB 2.116E-3 3.476E-2
2.527E-1
1.000E0
 1 7
50 19286929-SuppTable2n Mouse Lung Rangasamy09 254genes GeneSigDB 2.156E-3 3.476E-2
2.527E-1
1.000E0
 2 239
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 751 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Large Intestine/Brush cell of epithelium proper of large intestine Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Large Intestine/Brush cell of epithelium proper of large intestine Tabula Muris Consortium 1.760E-4 3.053E-2
2.198E-1
1.322E-1
 2 64
2 Lung Development Lungmap - Mouse FluidigmC1 Myeloid Overall Top 500 Genes Lung Development Lungmap - Mouse FluidigmC1 Myeloid Overall Top 500 Genes 1.979E-4 3.053E-2
2.198E-1
1.486E-1
 3 397
3 PP GMP 500 K2 PP GMP top-relative-expression-ranked 500 k-means-cluster#2 PCBC 2.291E-4 3.053E-2
2.198E-1
1.721E-1
 2 73
4 PP HSC 2500 K5 PP HSC top-relative-expression-ranked 2500 k-means-cluster#5 PCBC 2.997E-4 3.053E-2
2.198E-1
2.251E-1
 3 457
5 PP MEP 500 PP MEP top-relative-expression-ranked 500 PCBC 3.768E-4 3.053E-2
2.198E-1
2.829E-1
 3 494
6 PP HSC 500 PP HSC top-relative-expression-ranked 500 PCBC 3.768E-4 3.053E-2
2.198E-1
2.829E-1
 3 494
7 PP GMP 500 PP GMP top-relative-expression-ranked 500 PCBC 3.812E-4 3.053E-2
2.198E-1
2.863E-1
 3 496
8 PP MEG 500 PP MEG top-relative-expression-ranked 500 PCBC 3.835E-4 3.053E-2
2.198E-1
2.880E-1
 3 497
9 PP epoMEP 500 PP epoMEP top-relative-expression-ranked 500 PCBC 3.881E-4 3.053E-2
2.198E-1
2.914E-1
 3 499
10 PP MEP 500 K3 PP MEP top-relative-expression-ranked 500 k-means-cluster#3 PCBC 4.298E-4 3.053E-2
2.198E-1
3.228E-1
 2 100
11 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Tip/Endothelial Tip/Endothelial Tip/Dcn//Coch BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Tip/Endothelial Tip/Endothelial Tip/Dcn//Coch BrainMap 4.472E-4 3.053E-2
2.198E-1
3.358E-1
 2 102
12 PP HSC 500 K1 PP HSC top-relative-expression-ranked 500 k-means-cluster#1 PCBC 5.198E-4 3.253E-2
2.342E-1
3.904E-1
 2 110
13 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Limb Muscle/B cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Limb Muscle/B cell Tabula Muris Consortium 6.598E-4 3.386E-2
2.438E-1
4.955E-1
 2 124
14 PP MEG 500 K1 PP MEG top-relative-expression-ranked 500 k-means-cluster#1 PCBC 9.886E-4 3.386E-2
2.438E-1
7.425E-1
 2 152
15 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup2/Syt6/Syt6,Etv1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup2/Syt6/Syt6,Etv1 BrainMap 1.108E-3 3.386E-2
2.438E-1
8.321E-1
 2 161
16 10X Human 8K PBMC CD4 T cells Overall Top 200 Genes 10X Human 8K PBMC CD4 T cells Overall Top 200 Genes 1.163E-3 3.386E-2
2.438E-1
8.736E-1
 2 165
17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney F-U/Kidney Normal RCC F-U/Kidney Normal RCC F15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney F-U/Kidney Normal RCC F-U/Kidney Normal RCC F15 Adult, Development, and Cancer types 1.282E-3 3.386E-2
2.438E-1
9.629E-1
 1 4
18 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup2/Htr1a BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup2/Htr1a BrainMap 1.322E-3 3.386E-2
2.438E-1
9.927E-1
 2 176
19 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup7/Tac2/Tac2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup7/Tac2/Tac2 BrainMap 1.337E-3 3.386E-2
2.438E-1
1.000E0
 2 177
20 10X Human 8K PBMC B cell Overall Top 200 Genes 10X Human 8K PBMC B cell Overall Top 200 Genes 1.382E-3 3.386E-2
2.438E-1
1.000E0
 2 180
21 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Spleen/T cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Spleen/T cell Tabula Muris Consortium 1.428E-3 3.386E-2
2.438E-1
1.000E0
 2 183
22 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Microglia Overall Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Microglia Overall Top 200 Genes 1.443E-3 3.386E-2
2.438E-1
1.000E0
 2 184
23 BrainMap BrainAtlas - Mouse McCarroll Microglia Microglia Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Microglia Microglia Overall Top 200 Genes BrainMap 1.443E-3 3.386E-2
2.438E-1
1.000E0
 2 184
24 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Tip/Endothelial Tip/Endothelial Tip/Dcn//Rbp4 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Tip/Endothelial Tip/Endothelial Tip/Dcn//Rbp4 BrainMap 1.474E-3 3.386E-2
2.438E-1
1.000E0
 2 186
25 PP epoMEP 1000 K5 PP epoMEP top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 1.490E-3 3.386E-2
2.438E-1
1.000E0
 2 187
26 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow Tabula Muris Consortium 1.490E-3 3.386E-2
2.438E-1
1.000E0
 2 187
27 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Fat/B cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Fat/B cell Tabula Muris Consortium 1.490E-3 3.386E-2
2.438E-1
1.000E0
 2 187
28 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Spleen/B cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Spleen/B cell Tabula Muris Consortium 1.490E-3 3.386E-2
2.438E-1
1.000E0
 2 187
29 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour VHL RCC PT-U/Kidney Tumour VHL RCC PT21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour VHL RCC PT-U/Kidney Tumour VHL RCC PT21 Adult, Development, and Cancer types 1.522E-3 3.386E-2
2.438E-1
1.000E0
 2 189
30 ratio SC vs DE 1000 K1 ratio StemCell vs induced-DefinitiveEndoderm top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 1.538E-3 3.386E-2
2.438E-1
1.000E0
 2 190
31 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr//Ptprz1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr//Ptprz1 BrainMap 1.538E-3 3.386E-2
2.438E-1
1.000E0
 2 190
32 gudmap kidney e15.5 SmlBldVes Tie2 k4 500 kidney e15.5 SmlBldVes Tie2 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.538E-3 3.386E-2
2.438E-1
1.000E0
 2 190
33 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Microglia Subtype microglial.B Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Microglia Subtype microglial.B Top 200 Genes 1.554E-3 3.386E-2
2.438E-1
1.000E0
 2 191
34 BrainMap BrainAtlas - Mouse McCarroll Microglia Microglia Subtype Microglia.microglial.B Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Microglia Microglia Subtype Microglia.microglial.B Top 200 Genes BrainMap 1.554E-3 3.386E-2
2.438E-1
1.000E0
 2 191
35 Glioblastoma Single Cell Merged Immune cell Overall Top 200 Genes Glioblastoma Single Cell Merged Immune cell Overall Top 200 Genes 1.586E-3 3.386E-2
2.438E-1
1.000E0
 2 193
36 PP GMP 1000 K4 PP GMP top-relative-expression-ranked 1000 k-means-cluster#4 PCBC 1.635E-3 3.386E-2
2.438E-1
1.000E0
 2 196
37 PP HSC 1000 K2 PP HSC top-relative-expression-ranked 1000 k-means-cluster#2 PCBC 1.668E-3 3.386E-2
2.438E-1
1.000E0
 2 198
38 PP MEP 1000 K4 PP MEP top-relative-expression-ranked 1000 k-means-cluster#4 PCBC 1.753E-3 3.464E-2
2.494E-1
1.000E0
 2 203
39 PP epoMEP 500 K1 PP epoMEP top-relative-expression-ranked 500 k-means-cluster#1 PCBC 1.804E-3 3.474E-2
2.501E-1
1.000E0
 2 206
40 gudmap kidney P0 JuxtaGlom Ren1 k1 100 kidney P0 JuxtaGlom Ren1 k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.923E-3 3.610E-2
2.599E-1
1.000E0
 1 6
41 Lungmap Lungmap - Mouse FluidigmC1 Immune Immune Subtype B cell Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Immune Immune Subtype B cell Top 200 Genes 2.147E-3 3.932E-2
2.831E-1
1.000E0
 2 225
42 gudmap dev gonad e11.5 F ReproVasc Flk k4 500 dev gonad e11.5 F ReproVasc Flk k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.223E-3 3.974E-2
2.861E-1
1.000E0
 2 229
43 BrainMap BrainAtlas - Mouse McCarroll Microglia Microglia Subtype Microglia Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Microglia Microglia Subtype Microglia Top 200 Genes BrainMap 2.398E-3 4.002E-2
2.881E-1
1.000E0
 2 238
44 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Microglia Subtype microglial Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Microglia Subtype microglial Top 200 Genes 2.398E-3 4.002E-2
2.881E-1
1.000E0
 2 238
45 BrainMap BrainAtlas - Mouse McCarroll Microglia Microglia Subtype Microglia. Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Microglia Microglia Subtype Microglia. Top 200 Genes BrainMap 2.398E-3 4.002E-2
2.881E-1
1.000E0
 2 238
46 BrainMap BrainAtlas - Mouse McCarroll Microglia Microglia Top 200 BrainMap BrainAtlas - Mouse McCarroll Microglia Microglia Top 200 BrainMap 2.539E-3 4.056E-2
2.920E-1
1.000E0
 2 245
47 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Microglia Top 200 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Microglia Top 200 2.539E-3 4.056E-2
2.920E-1
1.000E0
 2 245
48 Lungmap Lungmap - Mouse FluidigmC1 Immune Immune Subtype B cell PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Immune Immune Subtype B cell PND07-28 Top 200 Genes 2.641E-3 4.133E-2
2.975E-1
1.000E0
 2 250
49 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Mural Subtype Acta2,Rgs5.Fos Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Mural Subtype Acta2,Rgs5.Fos Top 200 Genes 3.028E-3 4.641E-2
3.341E-1
1.000E0
 2 268
Show 44 more annotations

15: Computational [Display Chart] 5 input genes in category / 29 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 7 input genes in category / 212 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-346:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.355E-5 7.112E-3 4.222E-2 7.112E-3 2 92
2 hsa-miR-4269:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.670E-5 8.130E-3 4.826E-2 1.626E-2 2 139
3 hsa-miR-223-3p:TargetScan hsa-miR-223-3p TargetScan 3.148E-4 1.771E-2
1.051E-1
6.673E-2
 2 282
4 hsa-miR-718:mirSVR lowEffct hsa-miR-718:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.948E-4 1.771E-2
1.051E-1
8.369E-2
 2 316
5 hsa-miR-155-5p:TargetScan hsa-miR-155-5p TargetScan 5.905E-4 1.771E-2
1.051E-1
1.252E-1
 2 387
6 hsa-miR-614:mirSVR lowEffct hsa-miR-614:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 6.590E-4 1.771E-2
1.051E-1
1.397E-1
 2 409
7 hsa-miR-4670-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.750E-4 1.771E-2
1.051E-1
1.643E-1
 1 8
8 hsa-miR-591:mirSVR highEffct hsa-miR-591:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.929E-4 1.771E-2
1.051E-1
1.681E-1
 2 449
9 hsa-miR-1470:mirSVR lowEffct hsa-miR-1470:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.354E-4 1.771E-2
1.051E-1
1.771E-1
 2 461
10 hsa-miR-369-3p:TargetScan hsa-miR-369-3p TargetScan 8.354E-4 1.771E-2
1.051E-1
1.771E-1
 2 461
11 hsa-miR-1469:mirSVR highEffct hsa-miR-1469:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.840E-3 3.465E-2
2.057E-1
3.900E-1
 1 19
12 hsa-miR-4527:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.130E-3 3.465E-2
2.057E-1
4.515E-1
 1 22
13 hsa-miR-6503-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.130E-3 3.465E-2
2.057E-1
4.515E-1
 1 22
14 hsa-miR-1204:PITA hsa-miR-1204:PITA TOP PITA 2.420E-3 3.465E-2
2.057E-1
5.130E-1
 1 25
15 hsa-miR-4288:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.676E-3 3.465E-2
2.057E-1
7.794E-1
 1 38
16 hsa-miR-3142:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.773E-3 3.465E-2
2.057E-1
7.999E-1
 1 39
17 hsa-miR-1245b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 3.465E-2
2.057E-1
8.204E-1
 1 40
18 hsa-miR-632:Functional MTI Functional MTI miRTarbase 3.966E-3 3.465E-2
2.057E-1
8.408E-1
 1 41
19 hsa-miR-618:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.352E-3 3.465E-2
2.057E-1
9.227E-1
 1 45
20 hsa-miR-3140-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.028E-3 3.465E-2
2.057E-1
1.000E0
 1 52
21 hsa-miR-584-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.414E-3 3.465E-2
2.057E-1
1.000E0
 1 56
22 hsa-miR-2117:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.510E-3 3.465E-2
2.057E-1
1.000E0
 1 57
23 hsa-miR-145-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 3.465E-2
2.057E-1
1.000E0
 1 60
24 CCACACA,MIR-147:MSigDB CCACACA,MIR-147:MSigDB MSigDB 5.896E-3 3.465E-2
2.057E-1
1.000E0
 1 61
25 hsa-miR-4639-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.089E-3 3.465E-2
2.057E-1
1.000E0
 1 63
26 hsa-miR-609:PITA hsa-miR-609:PITA TOP PITA 6.185E-3 3.465E-2
2.057E-1
1.000E0
 1 64
27 GCAAGGA,MIR-502:MSigDB GCAAGGA,MIR-502:MSigDB MSigDB 6.185E-3 3.465E-2
2.057E-1
1.000E0
 1 64
28 hsa-miR-4277:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.185E-3 3.465E-2
2.057E-1
1.000E0
 1 64
29 hsa-miR-663b:PITA hsa-miR-663b:PITA TOP PITA 6.282E-3 3.465E-2
2.057E-1
1.000E0
 1 65
30 hsa-miR-4653-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.474E-3 3.465E-2
2.057E-1
1.000E0
 1 67
31 ACAACTT,MIR-382:MSigDB ACAACTT,MIR-382:MSigDB MSigDB 6.667E-3 3.465E-2
2.057E-1
1.000E0
 1 69
32 hsa-miR-4680-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.763E-3 3.465E-2
2.057E-1
1.000E0
 1 70
33 hsa-miR-654-3p:Functional MTI Functional MTI miRTarbase 6.763E-3 3.465E-2
2.057E-1
1.000E0
 1 70
34 hsa-miR-5000-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.763E-3 3.465E-2
2.057E-1
1.000E0
 1 70
35 hsa-miR-6126:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.763E-3 3.465E-2
2.057E-1
1.000E0
 1 70
36 hsa-miR-4725-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.052E-3 3.465E-2
2.057E-1
1.000E0
 1 73
37 hsa-miR-4493:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.438E-3 3.465E-2
2.057E-1
1.000E0
 1 77
38 hsa-miR-1245b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.630E-3 3.465E-2
2.057E-1
1.000E0
 1 79
39 hsa-miR-3975:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.726E-3 3.465E-2
2.057E-1
1.000E0
 1 80
40 hsa-miR-345-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.823E-3 3.465E-2
2.057E-1
1.000E0
 1 81
41 hsa-miR-376c-3p:Functional MTI Functional MTI miRTarbase 8.111E-3 3.465E-2
2.057E-1
1.000E0
 1 84
42 hsa-miR-4261:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.111E-3 3.465E-2
2.057E-1
1.000E0
 1 84
43 hsa-miR-148a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.208E-3 3.465E-2
2.057E-1
1.000E0
 1 85
44 hsa-miR-1183:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.208E-3 3.465E-2
2.057E-1
1.000E0
 1 85
45 hsa-miR-3188:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.304E-3 3.465E-2
2.057E-1
1.000E0
 1 86
46 hsa-miR-877-5p:TargetScan hsa-miR-877-5p TargetScan 8.592E-3 3.465E-2
2.057E-1
1.000E0
 1 89
47 hsa-miR-2467-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.592E-3 3.465E-2
2.057E-1
1.000E0
 1 89
48 hsa-miR-4709-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.689E-3 3.465E-2
2.057E-1
1.000E0
 1 90
49 AACTGAC,MIR-223:MSigDB AACTGAC,MIR-223:MSigDB MSigDB 8.977E-3 3.465E-2
2.057E-1
1.000E0
 1 93
50 hsa-miR-3191-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.073E-3 3.465E-2
2.057E-1
1.000E0
 1 94
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 1726 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000000009 AC1Q6SH8 Stitch 6.452E-11 1.114E-7 8.943E-7 1.114E-7 5 116
2 CID000002396 GF109203X Stitch 1.498E-8 1.293E-5 1.038E-4 2.585E-5 5 342
3 CID000010007 chlorphentermine Stitch 4.569E-8 2.629E-5 2.111E-4 7.886E-5 3 26
4 CID000192866 1,2-diglyceride Stitch 1.145E-7 3.922E-5 3.150E-4 1.976E-4 4 175
5 CID006439072 ST271 Stitch 1.149E-7 3.922E-5 3.150E-4 1.983E-4 3 35
6 CID005281656 norathyriol Stitch 1.363E-7 3.922E-5 3.150E-4 2.353E-4 3 37
7 CID006857413 AC1OAGKW Stitch 1.696E-7 4.181E-5 3.358E-4 2.927E-4 4 193
8 CID000004539 norfloxacin Stitch 2.487E-7 5.366E-5 4.310E-4 4.293E-4 3 45
9 CID000005772 Lypressin Stitch 2.841E-7 5.449E-5 4.376E-4 4.904E-4 3 47
10 CID000008823 xanthate Stitch 3.433E-7 5.926E-5 4.759E-4 5.926E-4 3 50
11 CID000133014 alpha-methylhomocysteine-thiolactone Stitch 4.592E-7 7.206E-5 5.787E-4 7.927E-4 3 55
12 CID000003391 (?-Fluprostenol Stitch 6.295E-7 8.375E-5 6.726E-4 1.087E-3 3 61
13 CID004183806 8-iso Misoprostol Stitch 6.614E-7 8.375E-5 6.726E-4 1.142E-3 3 62
14 CID009543520 triphosphoinositide Stitch 6.793E-7 8.375E-5 6.726E-4 1.172E-3 4 273
15 CID000002940 D 609 Stitch 7.285E-7 8.382E-5 6.732E-4 1.257E-3 3 64
16 CID005478935 Lopac-P-178 Stitch 8.373E-7 8.892E-5 7.141E-4 1.445E-3 3 67
17 CID000002681 cetyltrimethylammonium bromide Stitch 8.758E-7 8.892E-5 7.141E-4 1.512E-3 3 68
18 CID005312153 sulprostone Stitch 9.984E-7 9.478E-5 7.612E-4 1.723E-3 3 71
19 CID000004740 pentoxifylline Stitch 1.043E-6 9.478E-5 7.612E-4 1.801E-3 4 304
20 CID000130828 SKF83742 Stitch 1.207E-6 9.920E-5 7.967E-4 2.083E-3 2 6
21 CID000041624 C10A Stitch 1.207E-6 9.920E-5 7.967E-4 2.083E-3 2 6
22 CID000004629 oxotremorine-M Stitch 1.488E-6 1.168E-4 9.378E-4 2.569E-3 3 81
23 DB01863 Inositol 1,3,4,5-Tetrakisphosphate Drug Bank 1.689E-6 1.268E-4 1.018E-3 2.916E-3 2 7
24 CID000000805 D-myo-inositol 1,4-bisphosphate Stitch 1.784E-6 1.276E-4 1.024E-3 3.079E-3 3 86
25 CID000656725 reactive blue 2 Stitch 1.848E-6 1.276E-4 1.024E-3 3.189E-3 3 87
26 CID000461545 AGEPC Stitch 1.957E-6 1.299E-4 1.043E-3 3.378E-3 4 356
27 CID000100788 Araf-TC Stitch 2.334E-6 1.492E-4 1.198E-3 4.029E-3 3 94
28 CID005310996 ADP beta S Stitch 2.488E-6 1.533E-4 1.232E-3 4.294E-3 3 96
29 CID011979316 vasopressin Stitch 2.756E-6 1.640E-4 1.317E-3 4.757E-3 4 388
30 CID000008974 2-chloroadenosine Stitch 2.987E-6 1.719E-4 1.380E-3 5.156E-3 3 102
31 CID000005206 sevoflurane Stitch 3.260E-6 1.784E-4 1.433E-3 5.627E-3 3 105
32 CID006450086 Pl-cs Stitch 3.549E-6 1.784E-4 1.433E-3 6.125E-3 3 108
33 CID000005265 spiperone Stitch 3.549E-6 1.784E-4 1.433E-3 6.125E-3 3 108
34 CID000005235 sodium fluoride Stitch 3.549E-6 1.784E-4 1.433E-3 6.125E-3 3 108
35 CID002799766 3-nitrocoumarin Stitch 3.619E-6 1.784E-4 1.433E-3 6.246E-3 2 10
36 CID000552632 isopropyl-beta-D-thioglucoside Stitch 3.751E-6 1.798E-4 1.444E-3 6.474E-3 3 110
37 CID000005063 RHC 80267 Stitch 3.960E-6 1.847E-4 1.484E-3 6.835E-3 3 112
38 CID005460104 phosphatidate Stitch 4.261E-6 1.935E-4 1.554E-3 7.355E-3 4 433
39 CID005318627 isopetasin Stitch 4.422E-6 1.957E-4 1.572E-3 7.633E-3 2 11
40 CID003518809 Clorocruoro Hem Stitch 5.250E-6 2.211E-4 1.775E-3 9.062E-3 3 123
41 CID000004589 AC1L1II7 Stitch 5.306E-6 2.211E-4 1.775E-3 9.158E-3 2 12
42 CID000000478 AC1N9TEG Stitch 5.380E-6 2.211E-4 1.775E-3 9.285E-3 3 124
43 CID000003589 heptachlor Stitch 6.059E-6 2.432E-4 1.953E-3 1.046E-2 3 129
44 CID000003822 ketanserin Stitch 6.346E-6 2.434E-4 1.955E-3 1.095E-2 3 131
45 CID000002969 decanoate Stitch 6.346E-6 2.434E-4 1.955E-3 1.095E-2 3 131
46 CID000504578 AC1L9ZFX Stitch 6.792E-6 2.549E-4 2.047E-3 1.172E-2 3 134
47 CID000001050 pyridoxal Stitch 6.946E-6 2.551E-4 2.049E-3 1.199E-2 3 135
48 CID003504628 AC1MQNLW Stitch 7.313E-6 2.630E-4 2.112E-3 1.262E-2 2 14
49 CID000058035 AC1L1O6Q Stitch 7.915E-6 2.788E-4 2.239E-3 1.366E-2 3 141
50 CID000009308 muscarine Stitch 8.432E-6 2.911E-4 2.337E-3 1.455E-2 3 144
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 186 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 OMIN:307200 ISOLATED GROWTH HORMONE DEFICIENCY, TYPE III; IGHD3 OMIM 4.320E-4 7.304E-3 4.241E-2
8.035E-2
 1 1
2 cv:C1853124 Nephrotic syndrome, type 3 Clinical Variations 4.320E-4 7.304E-3 4.241E-2
8.035E-2
 1 1
3 C1843995 Enteroviral hepatitis DisGeNET Curated 4.320E-4 7.304E-3 4.241E-2
8.035E-2
 1 1
4 C3806660 Enteroviral dermatomyositis syndrome DisGeNET Curated 4.320E-4 7.304E-3 4.241E-2
8.035E-2
 1 1
5 C0472814 Autosomal agammaglobulinemia with absent B-cells DisGeNET BeFree 4.320E-4 7.304E-3 4.241E-2
8.035E-2
 1 1
6 C0398712 Anti-polysaccharide antibody deficiency DisGeNET BeFree 4.320E-4 7.304E-3 4.241E-2
8.035E-2
 1 1
7 C4280547 Infected joint DisGeNET Curated 4.320E-4 7.304E-3 4.241E-2
8.035E-2
 1 1
8 OMIN:610725 NEPHROTIC SYNDROME, TYPE 3; NPHS3 OMIM 4.320E-4 7.304E-3 4.241E-2
8.035E-2
 1 1
9 cv:C0221026 X-linked agammaglobulinemia Clinical Variations 4.320E-4 7.304E-3 4.241E-2
8.035E-2
 1 1
10 cv:C0472813 X-linked agammaglobulinemia with growth hormone deficiency Clinical Variations 4.320E-4 7.304E-3 4.241E-2
8.035E-2
 1 1
11 OMIN:300755 AGAMMAGLOBULINEMIA, X-LINKED; XLA OMIM 4.320E-4 7.304E-3 4.241E-2
8.035E-2
 1 1
12 C0014534 Epididymitis DisGeNET Curated 8.638E-4 9.451E-3
5.487E-2
1.607E-1
 1 2
13 C0008684 Chronic gingivitis DisGeNET BeFree 8.638E-4 9.451E-3
5.487E-2
1.607E-1
 1 2
14 C1853124 NEPHROTIC SYNDROME, TYPE 3 DisGeNET Curated 8.638E-4 9.451E-3
5.487E-2
1.607E-1
 1 2
15 C4025681 Recurrent enteroviral infections DisGeNET Curated 8.638E-4 9.451E-3
5.487E-2
1.607E-1
 1 2
16 C1865377 Small lymph nodes DisGeNET Curated 8.638E-4 9.451E-3
5.487E-2
1.607E-1
 1 2
17 C4025683 Lymph node hypoplasia DisGeNET Curated 8.638E-4 9.451E-3
5.487E-2
1.607E-1
 1 2
18 C0034212 Pyoderma DisGeNET Curated 1.295E-3 1.268E-2
7.362E-2
2.409E-1
 1 3
19 C0865214 Autosomal recessive agammaglobulinemia DisGeNET BeFree 1.295E-3 1.268E-2
7.362E-2
2.409E-1
 1 3
20 C4021957 Recurrent cutaneous abscess formation DisGeNET Curated 1.727E-3 1.530E-2
8.880E-2
3.212E-1
 1 4
21 C0241932 X-linked hypogammaglobulinemia DisGeNET BeFree 1.727E-3 1.530E-2
8.880E-2
3.212E-1
 1 4
22 C0027424 Nasal congestion (finding) DisGeNET Curated 2.158E-3 1.825E-2
1.059E-1
4.014E-1
 1 5
23 C0745242 Immunoglobulin deficiency DisGeNET BeFree 2.589E-3 2.094E-2
1.216E-1
4.816E-1
 1 6
24 C0175697 Van der Woude syndrome DisGeNET Curated 2.966E-3 2.292E-2
1.331E-1
5.517E-1
 2 197
25 C0162627 Skin Diseases, Bacterial DisGeNET Curated 3.451E-3 2.292E-2
1.331E-1
6.419E-1
 1 8
26 C0854802 Recurrent Chronic Lymphoid Leukemia DisGeNET BeFree 3.451E-3 2.292E-2
1.331E-1
6.419E-1
 1 8
27 C0007642 Cellulitis DisGeNET Curated 3.451E-3 2.292E-2
1.331E-1
6.419E-1
 1 8
28 C0376300 Dengue Shock Syndrome DisGeNET BeFree 3.882E-3 2.292E-2
1.331E-1
7.220E-1
 1 9
29 C0034072 Cor pulmonale DisGeNET Curated 3.882E-3 2.292E-2
1.331E-1
7.220E-1
 1 9
30 C0003869 Arthritis, Infectious DisGeNET Curated 3.882E-3 2.292E-2
1.331E-1
7.220E-1
 1 9
31 C1328587 Panhypogammaglobulinemia DisGeNET Curated 3.882E-3 2.292E-2
1.331E-1
7.220E-1
 1 9
32 C0267048 Glossoptosis DisGeNET Curated 4.312E-3 2.292E-2
1.331E-1
8.021E-1
 1 10
33 C4280678 Posterior displacement of the tongue DisGeNET Curated 4.312E-3 2.292E-2
1.331E-1
8.021E-1
 1 10
34 C0522274 Humoral immune defect DisGeNET BeFree 4.312E-3 2.292E-2
1.331E-1
8.021E-1
 1 10
35 C4021975 Abnormality of the tonsils DisGeNET Curated 4.312E-3 2.292E-2
1.331E-1
8.021E-1
 1 10
36 C1318020 Stromal keratitis DisGeNET BeFree 5.173E-3 2.601E-2
1.510E-1
9.622E-1
 1 12
37 C0149896 Primary gout DisGeNET BeFree 5.173E-3 2.601E-2
1.510E-1
9.622E-1
 1 12
38 C0268747 Diffuse mesangial sclerosis (disorder) DisGeNET Curated 5.603E-3 2.672E-2
1.551E-1
1.000E0
 1 13
39 C0472813 X-linked agammaglobulinemia with growth hormone deficiency DisGeNET Curated 5.603E-3 2.672E-2
1.551E-1
1.000E0
 1 13
40 C1333763 Gastric Cardia Carcinoma DisGeNET BeFree 7.322E-3 3.405E-2
1.977E-1
1.000E0
 1 17
41 C0280253 stage, gastric cancer DisGeNET BeFree 8.180E-3 3.711E-2
2.154E-1
1.000E0
 1 19
42 C0023461 Leukemia, Mast-Cell DisGeNET BeFree 8.609E-3 3.724E-2
2.162E-1
1.000E0
 1 20
43 C0085750 Adenosis of Breast DisGeNET BeFree 8.609E-3 3.724E-2
2.162E-1
1.000E0
 1 20
44 C1333296 Activated B-Cell-Like Diffuse Large B-Cell Lymphoma DisGeNET BeFree 9.466E-3 3.913E-2
2.272E-1
1.000E0
 1 22
45 C0001768 Agammaglobulinemia DisGeNET Curated 9.466E-3 3.913E-2
2.272E-1
1.000E0
 1 22
46 C3266102 Steroid resistant nephrotic syndrome of childhood DisGeNET BeFree 1.032E-2 4.166E-2
2.419E-1
1.000E0
 1 24
47 C0033581 prostatitis DisGeNET Curated 1.075E-2 4.166E-2
2.419E-1
1.000E0
 1 25
48 C0403397 Steroid-resistant nephrotic syndrome DisGeNET Curated 1.075E-2 4.166E-2
2.419E-1
1.000E0
 1 25
49 C0013338 Pituitary dwarfism DisGeNET Curated 1.161E-2 4.318E-2
2.507E-1
1.000E0
 1 27
50 C0267797 Acute hepatitis DisGeNET Curated 1.161E-2 4.318E-2
2.507E-1
1.000E0
 1 27
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