Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc311_6, positive side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 6 input genes in category / 15 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005148 prolactin receptor binding 2.584E-7 3.876E-6 1.286E-5 3.876E-6 2 3
2 GO:0005179 hormone activity 5.645E-6 4.233E-5 1.405E-4 8.467E-5 3 124
3 GO:0008083 growth factor activity 1.152E-3 5.762E-3 1.912E-2 1.729E-2 2 166
4 GO:0005131 growth hormone receptor binding 1.928E-3 7.229E-3 2.399E-2 2.892E-2 1 6
5 GO:0005126 cytokine receptor binding 3.441E-3 1.032E-2 3.425E-2
5.161E-2
 2 289
6 GO:0005154 epidermal growth factor receptor binding 1.056E-2 2.641E-2
8.764E-2
1.585E-1
 1 33
Show 1 more annotation

2: GO: Biological Process [Display Chart] 6 input genes in category / 173 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway 8.443E-9 1.461E-6 8.374E-6 1.461E-6 3 15
2 GO:0060396 growth hormone receptor signaling pathway 3.752E-8 2.458E-6 1.409E-5 6.490E-6 3 24
3 GO:0071378 cellular response to growth hormone stimulus 4.263E-8 2.458E-6 1.409E-5 7.374E-6 3 25
4 GO:0060416 response to growth hormone 1.438E-7 6.219E-6 3.566E-5 2.488E-5 3 37
5 GO:0043434 response to peptide hormone 4.522E-6 1.565E-4 8.970E-4 7.823E-4 4 442
6 GO:1901652 response to peptide 6.121E-6 1.765E-4 1.012E-3 1.059E-3 4 477
7 GO:0007259 JAK-STAT cascade 2.012E-5 4.351E-4 2.495E-3 3.481E-3 3 189
8 GO:0097696 STAT cascade 2.012E-5 4.351E-4 2.495E-3 3.481E-3 3 189
9 GO:0002090 regulation of receptor internalization 6.711E-5 1.290E-3 7.396E-3 1.161E-2 2 40
10 GO:0071375 cellular response to peptide hormone stimulus 1.004E-4 1.736E-3 9.956E-3 1.736E-2 3 324
11 GO:1901653 cellular response to peptide 1.158E-4 1.821E-3 1.044E-2 2.004E-2 3 340
12 GO:0040014 regulation of multicellular organism growth 3.052E-4 3.603E-3 2.066E-2
5.279E-2
 2 85
13 GO:0048259 regulation of receptor-mediated endocytosis 3.052E-4 3.603E-3 2.066E-2
5.279E-2
 2 85
14 GO:1904894 positive regulation of STAT cascade 3.124E-4 3.603E-3 2.066E-2
5.404E-2
 2 86
15 GO:0046427 positive regulation of JAK-STAT cascade 3.124E-4 3.603E-3 2.066E-2
5.404E-2
 2 86
16 GO:0031623 receptor internalization 3.346E-4 3.617E-3 2.074E-2
5.788E-2
 2 89
17 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis 6.443E-4 6.556E-3 3.759E-2
1.115E-1
 1 2
18 GO:0032355 response to estradiol 9.716E-4 8.847E-3
5.072E-2
1.681E-1
 2 152
19 GO:0030879 mammary gland development 9.716E-4 8.847E-3
5.072E-2
1.681E-1
 2 152
20 GO:0046425 regulation of JAK-STAT cascade 1.076E-3 8.862E-3
5.081E-2
1.861E-1
 2 160
21 GO:1904892 regulation of STAT cascade 1.076E-3 8.862E-3
5.081E-2
1.861E-1
 2 160
22 GO:0043112 receptor metabolic process 1.143E-3 8.991E-3
5.155E-2
1.978E-1
 2 165
23 GO:0035264 multicellular organism growth 1.358E-3 1.022E-2
5.858E-2
2.350E-1
 2 180
24 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation 1.610E-3 1.161E-2
6.654E-2
2.785E-1
 1 5
25 GO:0030278 regulation of ossification 1.774E-3 1.194E-2
6.843E-2
3.069E-1
 2 206
26 GO:0060751 branch elongation involved in mammary gland duct branching 1.932E-3 1.194E-2
6.843E-2
3.342E-1
 1 6
27 GO:0060744 mammary gland branching involved in thelarche 1.932E-3 1.194E-2
6.843E-2
3.342E-1
 1 6
28 GO:0042695 thelarche 1.932E-3 1.194E-2
6.843E-2
3.342E-1
 1 6
29 GO:0030100 regulation of endocytosis 2.130E-3 1.271E-2
7.284E-2
3.685E-1
 2 226
30 GO:0010536 positive regulation of activation of Janus kinase activity 2.253E-3 1.273E-2
7.298E-2
3.898E-1
 1 7
31 GO:0043627 response to estrogen 2.281E-3 1.273E-2
7.298E-2
3.946E-1
 2 234
32 GO:2000254 regulation of male germ cell proliferation 2.575E-3 1.392E-2
7.982E-2
4.455E-1
 1 8
33 GO:0046543 development of secondary female sexual characteristics 3.218E-3 1.546E-2
8.866E-2
5.567E-1
 1 10
34 GO:0010533 regulation of activation of Janus kinase activity 3.218E-3 1.546E-2
8.866E-2
5.567E-1
 1 10
35 GO:0002176 male germ cell proliferation 3.218E-3 1.546E-2
8.866E-2
5.567E-1
 1 10
36 GO:0030916 otic vesicle formation 3.218E-3 1.546E-2
8.866E-2
5.567E-1
 1 10
37 GO:0036093 germ cell proliferation 3.539E-3 1.611E-2
9.238E-2
6.123E-1
 1 11
38 GO:0060600 dichotomous subdivision of an epithelial terminal unit 3.539E-3 1.611E-2
9.238E-2
6.123E-1
 1 11
39 GO:0006898 receptor-mediated endocytosis 3.989E-3 1.764E-2
1.012E-1
6.901E-1
 2 311
40 GO:0045136 development of secondary sexual characteristics 4.182E-3 1.764E-2
1.012E-1
7.234E-1
 1 13
41 GO:0071600 otic vesicle morphogenesis 4.182E-3 1.764E-2
1.012E-1
7.234E-1
 1 13
42 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway 4.503E-3 1.812E-2
1.039E-1
7.790E-1
 1 14
43 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 4.503E-3 1.812E-2
1.039E-1
7.790E-1
 1 14
44 GO:0042711 maternal behavior 4.824E-3 1.857E-2
1.065E-1
8.345E-1
 1 15
45 GO:0048638 regulation of developmental growth 4.831E-3 1.857E-2
1.065E-1
8.358E-1
 2 343
46 GO:0042976 activation of Janus kinase activity 5.145E-3 1.894E-2
1.086E-1
8.900E-1
 1 16
47 GO:0060746 parental behavior 5.145E-3 1.894E-2
1.086E-1
8.900E-1
 1 16
48 GO:0043584 nose development 5.465E-3 1.970E-2
1.129E-1
9.455E-1
 1 17
49 GO:0071599 otic vesicle development 5.786E-3 2.002E-2
1.148E-1
1.000E0
 1 18
50 GO:0048853 forebrain morphogenesis 5.786E-3 2.002E-2
1.148E-1
1.000E0
 1 18
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 9 annotations before applied cutoff / 19061 genes in category

No results to display

4: Human Phenotype [Display Chart] 3 input genes in category / 294 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000839 Pituitary dwarfism 3.676E-5 1.081E-2
6.768E-2
 1.081E-2 2 17

5: Mouse Phenotype [Display Chart] 4 input genes in category / 250 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000662 abnormal branching of the mammary ductal tree 1.966E-4 1.888E-2
1.152E-1
 4.916E-2 2 60
2 MP:0009503 abnormal mammary gland duct morphology 3.243E-4 1.888E-2
1.152E-1
8.108E-2
 2 77
3 MP:0013356 ectopic pituitary gland 3.863E-4 1.888E-2
1.152E-1
9.657E-2
 1 1
4 MP:0013357 ectopic adenohypophysis 3.863E-4 1.888E-2
1.152E-1
9.657E-2
 1 1
5 MP:0013336 pituitary gland hypertrophy 3.863E-4 1.888E-2
1.152E-1
9.657E-2
 1 1
6 MP:0009504 abnormal mammary gland epithelium morphology 4.531E-4 1.888E-2
1.152E-1
1.133E-1
 2 91
7 MP:0004163 abnormal adenohypophysis morphology 5.691E-4 1.931E-2
1.178E-1
1.423E-1
 2 102
8 MP:0012004 abnormal septum pellucidum morphology 7.725E-4 1.931E-2
1.178E-1
1.931E-1
 1 2
9 MP:0012003 abnormal septum of telencephalon morphology 7.725E-4 1.931E-2
1.178E-1
1.931E-1
 1 2
10 MP:0012178 absent frontonasal prominence 7.725E-4 1.931E-2
1.178E-1
1.931E-1
 1 2
11 MP:0002098 abnormal vibrissa morphology 8.950E-4 2.013E-2
1.228E-1
2.238E-1
 2 128
12 MP:0000633 abnormal pituitary gland morphology 1.100E-3 2.013E-2
1.228E-1
2.751E-1
 2 142
13 MP:0000628 abnormal mammary gland development 1.293E-3 2.013E-2
1.228E-1
3.232E-1
 2 154
14 MP:0011237 decreased blood oxygen capacity 1.544E-3 2.013E-2
1.228E-1
3.861E-1
 1 4
15 MP:0013342 bifurcated Rathke's pouch 1.544E-3 2.013E-2
1.228E-1
3.861E-1
 1 4
16 MP:0013597 small vomeronasal organ 1.544E-3 2.013E-2
1.228E-1
3.861E-1
 1 4
17 MP:0008939 increased pituitary gland weight 1.544E-3 2.013E-2
1.228E-1
3.861E-1
 1 4
18 MP:0014198 absent pituitary infundibular stalk 1.544E-3 2.013E-2
1.228E-1
3.861E-1
 1 4
19 MP:0000631 abnormal neuroendocrine gland morphology 1.573E-3 2.013E-2
1.228E-1
3.933E-1
 2 170
20 MP:0009661 abnormal pregnancy 1.610E-3 2.013E-2
1.228E-1
4.025E-1
 2 172
21 MP:0004309 absent otic vesicle 1.930E-3 2.144E-2
1.308E-1
4.826E-1
 1 5
22 MP:0011235 abnormal blood oxygen capacity 1.930E-3 2.144E-2
1.308E-1
4.826E-1
 1 5
23 MP:0000635 pituitary gland hyperplasia 2.316E-3 2.144E-2
1.308E-1
5.790E-1
 1 6
24 MP:0009014 prolonged proestrus 2.316E-3 2.144E-2
1.308E-1
5.790E-1
 1 6
25 MP:0002580 duodenal lesions 2.316E-3 2.144E-2
1.308E-1
5.790E-1
 1 6
26 MP:0000661 small prostate gland ventral lobe 2.316E-3 2.144E-2
1.308E-1
5.790E-1
 1 6
27 MP:0009007 short estrous cycle 2.316E-3 2.144E-2
1.308E-1
5.790E-1
 1 6
28 MP:0002059 abnormal seminal vesicle morphology 2.436E-3 2.175E-2
1.327E-1
6.090E-1
 2 212
29 MP:0001297 microphthalmia 2.551E-3 2.179E-2
1.329E-1
6.377E-1
 2 217
30 MP:0010059 olfactory bulb hypoplasia 2.702E-3 2.179E-2
1.329E-1
6.754E-1
 1 7
31 MP:0009463 abnormal pituitary infundibular stalk morphology 2.702E-3 2.179E-2
1.329E-1
6.754E-1
 1 7
32 MP:0011759 absent Rathke's pouch 3.087E-3 2.296E-2
1.401E-1
7.718E-1
 1 8
33 MP:0008937 abnormal pituitary gland weight 3.087E-3 2.296E-2
1.401E-1
7.718E-1
 1 8
34 MP:0002697 abnormal eye size 3.138E-3 2.296E-2
1.401E-1
7.845E-1
 2 241
35 MP:0002787 pseudohermaphroditism 3.473E-3 2.296E-2
1.401E-1
8.681E-1
 1 9
36 MP:0002783 abnormal ovarian secretion 3.473E-3 2.296E-2
1.401E-1
8.681E-1
 1 9
37 MP:0013554 abnormal apocrine gland morphology 3.535E-3 2.296E-2
1.401E-1
8.837E-1
 2 256
38 MP:0000627 abnormal mammary gland morphology 3.535E-3 2.296E-2
1.401E-1
8.837E-1
 2 256
39 MP:0013330 abnormal male accessory sex gland morphology 3.617E-3 2.296E-2
1.401E-1
9.042E-1
 2 259
40 MP:0006306 abnormal nasal pit morphology 3.858E-3 2.296E-2
1.401E-1
9.645E-1
 1 10
41 MP:0003582 abnormal ovary development 3.858E-3 2.296E-2
1.401E-1
9.645E-1
 1 10
42 MP:0011121 decreased primordial ovarian follicle number 3.858E-3 2.296E-2
1.401E-1
9.645E-1
 1 10
43 MP:0011960 abnormal eye anterior chamber depth 4.243E-3 2.357E-2
1.438E-1
1.000E0
 1 11
44 MP:0000636 enlarged pituitary gland 4.243E-3 2.357E-2
1.438E-1
1.000E0
 1 11
45 MP:0011015 decreased body surface temperature 4.243E-3 2.357E-2
1.438E-1
1.000E0
 1 11
46 MP:0009013 abnormal proestrus 4.628E-3 2.361E-2
1.441E-1
1.000E0
 1 12
47 MP:0011119 abnormal primordial ovarian follicle number 4.628E-3 2.361E-2
1.441E-1
1.000E0
 1 12
48 MP:0009017 prolonged estrus 4.628E-3 2.361E-2
1.441E-1
1.000E0
 1 12
49 MP:0004096 abnormal midbrain-hindbrain boundary development 4.628E-3 2.361E-2
1.441E-1
1.000E0
 1 12
50 MP:0009380 abnormal prostate gland ventral lobe morphology 5.013E-3 2.457E-2
1.499E-1
1.000E0
 1 13
Show 45 more annotations

6: Domain [Display Chart] 6 input genes in category / 32 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR018116 Somatotropin CS InterPro 1.825E-10 2.919E-9 1.185E-8 5.839E-9 3 5
2 PS00266 SOMATOTROPIN 1 PROSITE 3.649E-10 2.919E-9 1.185E-8 1.168E-8 3 6
3 PS00338 SOMATOTROPIN 2 PROSITE 3.649E-10 2.919E-9 1.185E-8 1.168E-8 3 6
4 PF00103 Hormone 1 Pfam 3.649E-10 2.919E-9 1.185E-8 1.168E-8 3 6
5 IPR001400 Somatotropin InterPro 6.385E-10 4.086E-9 1.658E-8 2.043E-8 3 7
6 1.20.1250.10 - Gene3D 3.557E-7 1.728E-6 7.011E-6 1.138E-5 3 50
7 IPR012351 4 helix cytokine core InterPro 3.779E-7 1.728E-6 7.011E-6 1.209E-5 3 51
8 IPR009079 4 helix cytokine-like core InterPro 1.173E-6 4.692E-6 1.904E-5 3.754E-5 3 74
9 PF15913 Furin-like 2 Pfam 1.281E-3 4.553E-3 1.848E-2 4.098E-2 1 4
10 IPR015497 EGF rcpt ligand InterPro 2.240E-3 7.168E-3 2.909E-2
7.168E-2
 1 7
11 SM00261 FU SMART 5.752E-3 1.534E-2
6.225E-2
1.840E-1
 1 18
12 IPR006212 Furin repeat InterPro 5.752E-3 1.534E-2
6.225E-2
1.840E-1
 1 18
13 PF00090 TSP 1 Pfam 2.001E-2 4.128E-2
1.675E-1
6.403E-1
 1 63
14 SM00209 TSP1 SMART 2.064E-2 4.128E-2
1.675E-1
6.605E-1
 1 65
15 IPR000884 TSP1 rpt InterPro 2.064E-2 4.128E-2
1.675E-1
6.605E-1
 1 65
16 PS50092 TSP1 PROSITE 2.064E-2 4.128E-2
1.675E-1
6.605E-1
 1 65
Show 11 more annotations

7: Pathway [Display Chart] 6 input genes in category / 35 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269328 Prolactin receptor signaling BioSystems: REACTOME 3.475E-8 1.216E-6 5.043E-6 1.216E-6 3 16
2 1269327 Growth hormone receptor signaling BioSystems: REACTOME 1.425E-7 2.494E-6 1.034E-5 4.987E-6 3 25
3 M5883 Genes encoding secreted soluble factors MSigDB C2 BIOCARTA (v6.0) 8.224E-6 9.594E-5 3.979E-4 2.878E-4 4 344
4 83077 Jak-STAT signaling pathway BioSystems: KEGG 3.754E-5 3.285E-4 1.362E-3 1.314E-3 3 156
5 83051 Cytokine-cytokine receptor interaction BioSystems: KEGG 1.922E-4 1.222E-3 5.069E-3 6.727E-3 3 270
6 83053 Neuroactive ligand-receptor interaction BioSystems: KEGG 2.096E-4 1.222E-3 5.069E-3 7.335E-3 3 278
7 692234 PI3K-Akt signaling pathway BioSystems: KEGG 3.864E-4 1.932E-3 8.012E-3 1.352E-2 3 342
8 PW:0000170 epidermal growth factor/neuregulin signaling Pathway Ontology 1.927E-3 8.429E-3 3.495E-2
6.743E-2
 1 4
9 138016 ErbB receptor signaling network BioSystems: Pathway Interaction Database 6.250E-3 2.431E-2
1.008E-1
2.187E-1
 1 13
10 M13158 The IGF-1 Receptor and Longevity MSigDB C2 BIOCARTA (v6.0) 7.209E-3 2.523E-2
1.046E-1
2.523E-1
 1 15
11 1268748 Synthesis, secretion, and deacylation of Ghrelin BioSystems: REACTOME 9.124E-3 2.639E-2
1.095E-1
3.193E-1
 1 19
12 M15926 Trefoil Factors Initiate Mucosal Healing MSigDB C2 BIOCARTA (v6.0) 1.008E-2 2.639E-2
1.095E-1
3.528E-1
 1 21
13 1269607 Regulation of FZD by ubiquitination BioSystems: REACTOME 1.056E-2 2.639E-2
1.095E-1
3.695E-1
 1 22
14 M15258 AKT Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.056E-2 2.639E-2
1.095E-1
3.695E-1
 1 22
15 M9043 Growth Hormone Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.342E-2 2.936E-2
1.217E-1
4.697E-1
 1 28
16 137962 Wnt signaling network BioSystems: Pathway Interaction Database 1.342E-2 2.936E-2
1.217E-1
4.697E-1
 1 28
17 137991 ErbB4 signaling events BioSystems: Pathway Interaction Database 1.533E-2 3.155E-2
1.308E-1
5.364E-1
 1 32
18 1309087 Cargo concentration in the ER BioSystems: REACTOME 1.628E-2 3.165E-2
1.312E-1
5.697E-1
 1 34
19 138017 Signaling events mediated by PTP1B BioSystems: Pathway Interaction Database 2.386E-2 4.395E-2
1.823E-1
8.351E-1
 1 50
Show 14 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 1460 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 26697363 Third party data gene data set of eutherian growth hormone genes. Pubmed 4.307E-11 3.144E-8 2.473E-7 6.289E-8 3 6
2 26862561 Curated eutherian third party data gene data sets. Pubmed 4.307E-11 3.144E-8 2.473E-7 6.289E-8 3 6
3 6306568 The human growth hormone gene family: structure and evolution of the chromosomal locus. Pubmed 2.057E-8 4.290E-6 3.373E-5 3.003E-5 2 2
4 19051037 Pituitary-hormone secretion by thyrotropinomas. Pubmed 2.057E-8 4.290E-6 3.373E-5 3.003E-5 2 2
5 28700563 The relationship between serum levels of prolactin and growth hormone in the early postnatal period. Pubmed 2.057E-8 4.290E-6 3.373E-5 3.003E-5 2 2
6 12445833 Cortisol, prolactin, growth hormone and neurovegetative responses to emotions elicited during an hypnoidal state. Pubmed 2.057E-8 4.290E-6 3.373E-5 3.003E-5 2 2
7 16424673 Autosomal-dominant isolated growth hormone deficiency (IGHD type II) with normal GH-1 gene. Pubmed 2.057E-8 4.290E-6 3.373E-5 3.003E-5 2 2
8 21277631 Oxytocin does not modify GH, ACTH, cortisol and prolactin responses to Ghrelin in normal men. Pubmed 6.170E-8 7.506E-6 5.903E-5 9.008E-5 2 3
9 11994274 Autocrine human growth hormone inhibits placental transforming growth factor-beta gene transcription to prevent apoptosis and allow cell cycle progression of human mammary carcinoma cells. Pubmed 6.170E-8 7.506E-6 5.903E-5 9.008E-5 2 3
10 14595650 Growth hormone prevents human immunodeficiency virus-induced neuronal p53 expression. Pubmed 6.170E-8 7.506E-6 5.903E-5 9.008E-5 2 3
11 18432585 Plasma levels of Th1/Th2 type cytokine are associated with change of prolactin and GH/IGF-I in hemodialysis patients. Pubmed 6.170E-8 7.506E-6 5.903E-5 9.008E-5 2 3
12 7072716 Chromosomal localization of the human placental lactogen-growth hormone gene cluster to 17q22-24. Pubmed 6.170E-8 7.506E-6 5.903E-5 9.008E-5 2 3
13 16133148 Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line. Pubmed 1.234E-7 1.060E-5 8.333E-5 1.801E-4 2 4
14 20427283 Obligate ordered binding of human lactogenic cytokines. Pubmed 1.234E-7 1.060E-5 8.333E-5 1.801E-4 2 4
15 7169009 The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. Pubmed 1.234E-7 1.060E-5 8.333E-5 1.801E-4 2 4
16 6262212 The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21 to qter. Pubmed 1.234E-7 1.060E-5 8.333E-5 1.801E-4 2 4
17 8943276 Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution. Pubmed 1.234E-7 1.060E-5 8.333E-5 1.801E-4 2 4
18 23178941 HIV-1 Tat protein inhibits neurosecretion by binding to phosphatidylinositol 4,5-bisphosphate. Pubmed 2.056E-7 1.580E-5 1.243E-4 3.002E-4 2 5
19 7984244 The X-ray structure of a growth hormone-prolactin receptor complex. Pubmed 2.056E-7 1.580E-5 1.243E-4 3.002E-4 2 5
20 2744760 The human growth hormone locus: nucleotide sequence, biology, and evolution. Pubmed 3.084E-7 2.251E-5 1.770E-4 4.503E-4 2 6
21 20403354 A population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence. Pubmed 4.318E-7 2.865E-5 2.253E-4 6.304E-4 2 7
22 1980158 Hot spots for growth hormone gene deletions in homologous regions outside of Alu repeats. Pubmed 4.318E-7 2.865E-5 2.253E-4 6.304E-4 2 7
23 12552091 Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. Pubmed 9.250E-7 5.872E-5 4.617E-4 1.350E-3 2 10
24 28506993 MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma. Pubmed 2.466E-6 1.500E-4 1.179E-3 3.600E-3 2 16
25 8934515 Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Pubmed 2.794E-6 1.632E-4 1.283E-3 4.079E-3 2 17
26 26764381 Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans. Pubmed 3.513E-6 1.973E-4 1.551E-3 5.129E-3 2 19
27 27226320 SOX2 is sequentially required for progenitor proliferation and lineage specification in the developing pituitary. Pubmed 4.313E-6 2.249E-4 1.769E-3 6.297E-3 2 21
28 19093031 Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism. Pubmed 4.313E-6 2.249E-4 1.769E-3 6.297E-3 2 21
29 18775421 Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. Pubmed 5.196E-6 2.616E-4 2.057E-3 7.586E-3 2 23
30 12130660 Tissue-specific regulation of retinal and pituitary precursor cell proliferation. Pubmed 5.668E-6 2.758E-4 2.169E-3 8.275E-3 2 24
31 22945632 SOX2 regulates the hypothalamic-pituitary axis at multiple levels. Pubmed 6.673E-6 3.143E-4 2.471E-3 9.743E-3 2 26
32 21636786 Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Pubmed 7.206E-6 3.288E-4 2.586E-3 1.052E-2 2 27
33 24227653 Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Pubmed 1.221E-5 3.914E-4 3.078E-3 1.783E-2 2 35
34 16678101 Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Pubmed 1.366E-5 3.914E-4 3.078E-3 1.995E-2 2 37
35 28807898 Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors. Pubmed 2.216E-5 3.914E-4 3.078E-3 3.236E-2 2 47
36 23639781 Clinical and neurohormonal correlates and prognostic value of serum prolactin levels in patients with chronic heart failure. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
37 16807649 Enhanced platelet activation by prolactin in patients with ischemic stroke. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
38 15601751 Transgenic prolactin-/- mice: effect of trauma-hemorrhage on splenocyte functions. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
39 26485222 IGHD II: A Novel GH-1 Gene Mutation (GH-L76P) Severely Affects GH Folding, Stability, and Secretion. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
40 28427901 The 20kDa and 22kDa forms of human growth hormone (hGH) exhibit different intracellular signalling profiles and properties. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
41 21249719 Stability of human growth hormone: influence of methionine oxidation on thermal folding. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
42 9389542 Three new members of the mouse prolactin/growth hormone family are homologous to proteins expressed in the rat. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
43 18413425 Role of growth hormone in regulating lipolysis, proteolysis, and hepatic glucose production during fasting. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
44 19092717 Differential effects of growth hormone and alpha calcidol on trabecular and cortical bones in hypophysectomized rats. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
45 26527289 Amphiregulin Is a Critical Downstream Effector of Estrogen Signaling in ERα-Positive Breast Cancer. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
46 27040371 Regulatory T-cell-intrinsic amphiregulin is dispensable for suppressive function. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
47 16083754 The effect of growth hormone on gut mucosal homeostasis and cellular mediators after severe trauma. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
48 19451414 Prolactin and preclinical atherosclerosis in menopausal women with cardiovascular risk factors. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
49 18686625 Mek and p38 MAPK-dependant pathways are involoved in the positive effect of interleukin-6 on human growth hormone gene expression in rat MtT/S somatotroph cells. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
50 16045928 Solution structure of human prolactin. Pubmed 1.571E-4 3.914E-4 3.078E-3
2.294E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 53 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PRLR PRLR interactions 3.100E-5 1.643E-3 7.487E-3 1.643E-3 2 26
2 int:GHR GHR interactions 1.072E-4 2.842E-3 1.295E-2 5.684E-3 2 48
3 int:GH2 GH2 interactions 1.355E-3 1.827E-2
8.324E-2
7.182E-2
 1 4
4 int:PRL PRL interactions 1.694E-3 1.827E-2
8.324E-2
8.976E-2
 1 5
5 int:UBQLN4 UBQLN4 interactions 1.723E-3 1.827E-2
8.324E-2
9.133E-2
 2 193
6 int:PROP1 PROP1 interactions 2.709E-3 1.897E-2
8.646E-2
1.436E-1
 1 8
7 int:HLA-DQB2 HLA-DQB2 interactions 3.047E-3 1.897E-2
8.646E-2
1.615E-1
 1 9
8 int:GH1 GH1 interactions 3.047E-3 1.897E-2
8.646E-2
1.615E-1
 1 9
9 int:CSH1 CSH1 interactions 4.061E-3 1.897E-2
8.646E-2
2.152E-1
 1 12
10 int:RSPO1 RSPO1 interactions 4.399E-3 1.897E-2
8.646E-2
2.331E-1
 1 13
11 int:AREG AREG interactions 4.399E-3 1.897E-2
8.646E-2
2.331E-1
 1 13
12 int:ZNRF3 ZNRF3 interactions 4.399E-3 1.897E-2
8.646E-2
2.331E-1
 1 13
13 int:HESX1 HESX1 interactions 4.736E-3 1.897E-2
8.646E-2
2.510E-1
 1 14
14 int:METAP1 METAP1 interactions 5.074E-3 1.897E-2
8.646E-2
2.689E-1
 1 15
15 int:RBP4 RBP4 interactions 5.411E-3 1.897E-2
8.646E-2
2.868E-1
 1 16
16 int:SRFBP1 SRFBP1 interactions 5.749E-3 1.897E-2
8.646E-2
3.047E-1
 1 17
17 int:ADCY9 ADCY9 interactions 6.086E-3 1.897E-2
8.646E-2
3.226E-1
 1 18
18 int:RNF43 RNF43 interactions 7.097E-3 2.088E-2
9.514E-2
3.762E-1
 1 21
19 int:SNX11 SNX11 interactions 8.108E-3 2.088E-2
9.514E-2
4.297E-1
 1 24
20 int:LTA4H LTA4H interactions 8.781E-3 2.088E-2
9.514E-2
4.654E-1
 1 26
21 int:LONP2 LONP2 interactions 8.781E-3 2.088E-2
9.514E-2
4.654E-1
 1 26
22 int:ZNF592 ZNF592 interactions 8.781E-3 2.088E-2
9.514E-2
4.654E-1
 1 26
23 int:ISCA1 ISCA1 interactions 9.454E-3 2.088E-2
9.514E-2
5.011E-1
 1 28
24 int:NPAS2 NPAS2 interactions 9.454E-3 2.088E-2
9.514E-2
5.011E-1
 1 28
25 int:LRP1B LRP1B interactions 1.080E-2 2.289E-2
1.043E-1
5.723E-1
 1 32
26 int:ZNF579 ZNF579 interactions 1.248E-2 2.543E-2
1.159E-1
6.613E-1
 1 37
27 int:MMP9 MMP9 interactions 1.482E-2 2.910E-2
1.326E-1
7.856E-1
 1 44
28 int:LACRT LACRT interactions 1.549E-2 2.932E-2
1.336E-1
8.211E-1
 1 46
29 int:HECTD3 HECTD3 interactions 1.683E-2 3.076E-2
1.402E-1
8.920E-1
 1 50
30 int:SORL1 SORL1 interactions 1.750E-2 3.091E-2
1.409E-1
9.274E-1
 1 52
31 int:CHTOP CHTOP interactions 1.850E-2 3.163E-2
1.441E-1
9.805E-1
 1 55
32 int:ZZEF1 ZZEF1 interactions 1.950E-2 3.230E-2
1.472E-1
1.000E0
 1 58
33 int:WT1 WT1 interactions 2.083E-2 3.346E-2
1.525E-1
1.000E0
 1 62
34 int:NEURL4 NEURL4 interactions 2.283E-2 3.457E-2
1.575E-1
1.000E0
 1 68
35 int:CCND3 CCND3 interactions 2.283E-2 3.457E-2
1.575E-1
1.000E0
 1 68
36 int:WDR92 WDR92 interactions 2.549E-2 3.752E-2
1.710E-1
1.000E0
 1 76
37 int:STRAP STRAP interactions 3.606E-2 4.944E-2
2.253E-1
1.000E0
 1 108
38 int:SAFB SAFB interactions 3.606E-2 4.944E-2
2.253E-1
1.000E0
 1 108
39 int:PPIB PPIB interactions 3.638E-2 4.944E-2
2.253E-1
1.000E0
 1 109
40 int:DNMT1 DNMT1 interactions 3.770E-2 4.995E-2
2.276E-1
1.000E0
 1 113
Show 35 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17q24.2 17q24.2 1.159E-5 5.793E-5 1.323E-4 5.793E-5 2 31
2 6p22.2-p21.3 6p22.2-p21.3 1.731E-4 4.328E-4 9.881E-4 8.655E-4 1 1
3 3p14.3 3p14.3 5.182E-3 8.637E-3 1.972E-2 2.591E-2 1 30
4 4q13.3 4q13.3 7.593E-3 9.491E-3 2.167E-2 3.797E-2 1 44
5 1p34.3 1p34.3 1.137E-2 1.137E-2 2.596E-2
5.686E-2
 1 66

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 54 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$POU1F1 Q6 V$POU1F1 Q6 7.035E-5 3.799E-3 1.738E-2 3.799E-3 3 190

12: Gene Family [Display Chart] 6 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1175 Endogenous ligands|Growth hormone family genenames.org 3.984E-10 1.195E-9 2.191E-9 1.195E-9 3 6
2 542 Endogenous ligands genenames.org 4.126E-7 6.189E-7 1.135E-6 1.238E-6 4 237
3 521 PRD class homeoboxes and pseudogenes genenames.org 2.996E-2 2.996E-2
5.493E-2
8.989E-2
 1 92

13: Coexpression [Display Chart] 6 input genes in category / 466 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16288009-Table2 Human StemCell Moreno05 44genes GeneSigDB 1.108E-7 5.164E-5 3.472E-4 5.164E-5 3 42
2 16288009-SuppTable2 Human StemCell Moreno05 297genes GeneSigDB 2.929E-5 6.423E-3 4.318E-2 1.365E-2 3 266
3 M1760 Genes down-regulated after Cre-lox knockout of LSD1 [GeneID=23028] in pituitary. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.135E-5 6.423E-3 4.318E-2 1.927E-2 2 39
4 20460173-ImmPortCytokines Human Immune Kong10 456genes ImmPort Cytokines GeneSigDB 1.248E-4 1.454E-2
9.777E-2
5.817E-2
 3 433
5 M2690 Genes up-regulated in C57MG cells (mammary epithelium) by over-expression of WNT1 [Gene ID=7471] gene. MSigDB C6: Oncogenic Signatures (v6.0) 8.845E-4 4.233E-2
2.846E-1
4.122E-1
 2 180
6 M7238 Genes up-regulated in cortical thymocytes versus thymus whole cortex. MSigDB C7: Immunologic Signatures (v6.0) 1.058E-3 4.233E-2
2.846E-1
4.930E-1
 2 197
7 M5011 Genes up-regulated in comparison of B cells from LAIV influenza vaccinee at day 7 post-vaccination versus those from TIV influenza vaccinee at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 4.233E-2
2.846E-1
5.029E-1
 2 199
8 M5538 Genes up-regulated in comparison of B cells versus basophils. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 4.233E-2
2.846E-1
5.029E-1
 2 199
9 M5156 Genes down-regulated in comparison of dendritic cells (DC) versus DCs exposed to M.tuberculosis. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.233E-2
2.846E-1
5.080E-1
 2 200
10 M9666 Genes up-regulated in CD4 [GeneID=920] T helper cells Th0: 1h versus 60h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.233E-2
2.846E-1
5.080E-1
 2 200
11 M5192 Genes up-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to L. major. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.233E-2
2.846E-1
5.080E-1
 2 200
12 M3913 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.233E-2
2.846E-1
5.080E-1
 2 200
13 M17702 Genes genes down-regulated in NT2/D1 cells (embryonal carcinoma) in response to treatment with cisplatin [PubChem=2767]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.296E-3 4.314E-2
2.900E-1
6.040E-1
 1 5
14 M2303 Genes up-regulated in normal 9.5 days post coitus (dpc) embryos compared to normal 8.5 dpc and 9.5 dpc embryos. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.296E-3 4.314E-2
2.900E-1
6.040E-1
 1 5
Show 9 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 434 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 placenta placenta Human Protein Atlas 9.394E-7 4.077E-4 2.712E-3 4.077E-4 4 349
2 Facebase ST1 e8.5 ParaxMesoderm 100 e8.5 ParaxMesoderm top-relative-expression-ranked 100 FaceBase_ST1 2.121E-4 3.771E-2
2.508E-1
9.207E-2
 2 83
3 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type B2/1/2 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type B2/1/2 TCGA-Thymus 2.607E-4 3.771E-2
2.508E-1
1.131E-1
 2 92
4 endometrium endometrium Human Protein Atlas 4.070E-4 4.416E-2
2.938E-1
1.767E-1
 2 115

15: Computational [Display Chart] 4 input genes in category / 34 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 6 input genes in category / 42 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-654-5p:mirSVR highEffct hsa-miR-654-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.253E-4 1.375E-2
5.948E-2
 2.626E-2 2 471
2 hsa-miR-541:mirSVR highEffct hsa-miR-541:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.547E-4 1.375E-2
5.948E-2
 2.750E-2 2 482
3 hsa-miR-3923:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.992E-3 2.148E-2
9.296E-2
8.365E-2
 1 24
4 hsa-miR-24-2-5p:Functional MTI Functional MTI miRTarbase 2.655E-3 2.148E-2
9.296E-2
1.115E-1
 1 32
5 hsa-miR-24-1-5p:Functional MTI Functional MTI miRTarbase 2.986E-3 2.148E-2
9.296E-2
1.254E-1
 1 36
6 hsa-miR-3651:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.069E-3 2.148E-2
9.296E-2
1.289E-1
 1 37
7 hsa-miR-6779-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.973E-3 2.246E-2
9.718E-2
2.089E-1
 1 60
8 hsa-miR-4687-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.304E-3 2.246E-2
9.718E-2
2.228E-1
 1 64
9 hsa-miR-129-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.552E-3 2.246E-2
9.718E-2
2.332E-1
 1 67
10 hsa-miR-101-5p:Functional MTI Functional MTI miRTarbase 5.635E-3 2.246E-2
9.718E-2
2.367E-1
 1 68
11 hsa-miR-129-2-3p:Functional MTI Functional MTI miRTarbase 5.883E-3 2.246E-2
9.718E-2
2.471E-1
 1 71
12 hsa-miR-4272:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.287E-3 2.359E-2
1.021E-1
3.060E-1
 1 88
13 hsa-miR-644a:Functional MTI Functional MTI miRTarbase 7.700E-3 2.359E-2
1.021E-1
3.234E-1
 1 93
14 hsa-miR-3911:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.865E-3 2.359E-2
1.021E-1
3.303E-1
 1 95
15 hsa-miR-6758-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.937E-3 2.502E-2
1.083E-1
3.753E-1
 1 108
16 hsa-miR-4795-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.017E-2 2.670E-2
1.155E-1
4.273E-1
 1 123
17 hsa-miR-6507-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.091E-2 2.696E-2
1.167E-1
4.584E-1
 1 132
18 hsa-miR-147a:Functional MTI Functional MTI miRTarbase 1.231E-2 2.724E-2
1.178E-1
5.171E-1
 1 149
19 hsa-miR-200a-3p:Functional MTI Functional MTI miRTarbase 1.239E-2 2.724E-2
1.178E-1
5.206E-1
 1 150
20 hsa-miR-1282:mirSVR highEffct hsa-miR-1282:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.297E-2 2.724E-2
1.178E-1
5.447E-1
 1 157
21 hsa-miR-297:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.568E-2 3.009E-2
1.302E-1
6.585E-1
 1 190
22 hsa-miR-567:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.576E-2 3.009E-2
1.302E-1
6.619E-1
 1 191
23 hsa-miR-517a:mirSVR highEffct hsa-miR-517a:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.658E-2 3.027E-2
1.310E-1
6.963E-1
 1 201
24 AACTGGA,MIR-145:MSigDB AACTGGA,MIR-145:MSigDB MSigDB 1.854E-2 3.245E-2
1.404E-1
7.788E-1
 1 225
25 hsa-miR-517c:mirSVR highEffct hsa-miR-517c:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.132E-2 3.308E-2
1.431E-1
8.954E-1
 1 259
26 hsa-miR-1973:mirSVR lowEffct hsa-miR-1973:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.140E-2 3.308E-2
1.431E-1
8.989E-1
 1 260
27 hsa-miR-511-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.148E-2 3.308E-2
1.431E-1
9.023E-1
 1 261
28 hsa-miR-891b:PITA hsa-miR-891b:PITA TOP PITA 2.205E-2 3.308E-2
1.431E-1
9.263E-1
 1 268
29 hsa-miR-223-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.336E-2 3.383E-2
1.464E-1
9.810E-1
 1 284
30 hsa-miR-1247:mirSVR lowEffct hsa-miR-1247:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.515E-2 3.503E-2
1.516E-1
1.000E0
 1 306
31 hsa-miR-224-5p:TargetScan hsa-miR-224-5p TargetScan 2.645E-2 3.503E-2
1.516E-1
1.000E0
 1 322
32 hsa-miR-887:mirSVR lowEffct hsa-miR-887:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.669E-2 3.503E-2
1.516E-1
1.000E0
 1 325
33 hsa-miR-31*:mirSVR highEffct hsa-miR-31*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.945E-2 3.748E-2
1.622E-1
1.000E0
 1 359
34 hsa-miR-574-5p:Functional MTI Functional MTI miRTarbase 3.398E-2 3.945E-2
1.707E-1
1.000E0
 1 415
35 hsa-miR-4296:mirSVR highEffct hsa-miR-4296:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.624E-2 3.945E-2
1.707E-1
1.000E0
 1 443
36 hsa-miR-4265:mirSVR highEffct hsa-miR-4265:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.664E-2 3.945E-2
1.707E-1
1.000E0
 1 448
37 hsa-miR-371-3p:mirSVR lowEffct hsa-miR-371-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.680E-2 3.945E-2
1.707E-1
1.000E0
 1 450
38 hsa-miR-6867-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.752E-2 3.945E-2
1.707E-1
1.000E0
 1 459
39 hsa-miR-4322:mirSVR highEffct hsa-miR-4322:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.841E-2 3.945E-2
1.707E-1
1.000E0
 1 470
40 hsa-miR-377-3p:TargetScan hsa-miR-377-3p TargetScan 3.865E-2 3.945E-2
1.707E-1
1.000E0
 1 473
41 hsa-miR-886-3p:mirSVR lowEffct hsa-miR-886-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.865E-2 3.945E-2
1.707E-1
1.000E0
 1 473
42 hsa-miR-181c*:mirSVR lowEffct hsa-miR-181c*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.945E-2 3.945E-2
1.707E-1
1.000E0
 1 483
Show 37 more annotations

17: Drug [Display Chart] 6 input genes in category / 1581 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000036523 Factrel Stitch 8.276E-10 1.309E-6 1.039E-5 1.309E-6 5 246
2 CID000148770 3'dGTP Stitch 4.577E-9 3.618E-6 2.874E-5 7.236E-6 3 15
3 CID011446521 SureCN160413 Stitch 9.914E-8 5.225E-5 4.150E-4 1.567E-4 3 40
4 CID000032281 TRH-T Stitch 1.734E-7 6.855E-5 5.445E-4 2.742E-4 3 48
5 CID006321294 GHRP Stitch 3.604E-7 1.075E-4 8.540E-4 5.698E-4 3 61
6 CID000198577 Diacetam 5 Stitch 5.477E-7 1.075E-4 8.540E-4 8.659E-4 3 70
7 CID000078964 prostaglandins G Stitch 5.718E-7 1.075E-4 8.540E-4 9.040E-4 3 71
8 CID009571040 PBGH Stitch 5.749E-7 1.075E-4 8.540E-4 9.088E-4 2 5
9 CID000178024 MK-677 Stitch 6.221E-7 1.075E-4 8.540E-4 9.835E-4 3 73
10 CID000086807 T-E-A-T Stitch 7.029E-7 1.075E-4 8.540E-4 1.111E-3 3 76
11 CID000131305 Ttatpn Stitch 8.622E-7 1.075E-4 8.540E-4 1.363E-3 2 6
12 CID000133813 AC1Q5XN3 Stitch 8.622E-7 1.075E-4 8.540E-4 1.363E-3 2 6
13 CID000002512 Cabergoline-d5 Stitch 9.181E-7 1.075E-4 8.540E-4 1.452E-3 3 83
14 CID000004168 metoclopramide Stitch 9.520E-7 1.075E-4 8.540E-4 1.505E-3 3 84
15 CID000002256 atrazine Stitch 1.173E-6 1.236E-4 9.821E-4 1.855E-3 3 90
16 CID000004991 pyridostigmine Stitch 1.295E-6 1.252E-4 9.948E-4 2.048E-3 3 93
17 CID004631604 1n9a Stitch 1.381E-6 1.252E-4 9.948E-4 2.184E-3 3 95
18 CID004345065 GHRP-6 Stitch 1.426E-6 1.252E-4 9.948E-4 2.254E-3 3 96
19 CID005487480 Ghrp 1 Stitch 2.069E-6 1.721E-4 1.367E-3 3.270E-3 2 9
20 CID006327189 boron monoxide Stitch 2.867E-6 2.212E-4 1.757E-3 4.532E-3 3 121
21 CID000000812 NSC20266 Stitch 2.939E-6 2.212E-4 1.757E-3 4.646E-3 3 122
22 ctd:D003533 Cyproheptadine CTD 3.159E-6 2.271E-4 1.804E-3 4.995E-3 2 11
23 ctd:D011732 Pyridoxal Phosphate CTD 3.791E-6 2.497E-4 1.984E-3 5.993E-3 2 12
24 ctd:D019329 Idazoxan CTD 3.791E-6 2.497E-4 1.984E-3 5.993E-3 2 12
25 CID000002443 alpha-bromoergocriptine Stitch 4.641E-6 2.935E-4 2.331E-3 7.338E-3 3 142
26 CID000121879 L-692,429 Stitch 7.807E-6 4.747E-4 3.771E-3 1.234E-2 2 17
27 ctd:C076715 pervanadate CTD 9.814E-6 5.747E-4 4.565E-3 1.552E-2 2 19
28 CID000023982 gadolinium Stitch 1.278E-5 7.148E-4 5.678E-3 2.020E-2 3 199
29 CID000122057 Deamido-trh Stitch 1.325E-5 7.148E-4 5.678E-3 2.095E-2 2 22
30 CID000005033 radicicol Stitch 1.356E-5 7.148E-4 5.678E-3 2.145E-2 3 203
31 CID000029575 HxCDD Stitch 1.451E-5 7.402E-4 5.879E-3 2.295E-2 2 23
32 CID000009035 KC-33 Stitch 1.583E-5 7.821E-4 6.213E-3 2.503E-2 2 24
33 CID000104778 levodopa/carbidopa Stitch 1.864E-5 8.929E-4 7.092E-3 2.947E-2 2 26
34 ctd:D001058 Apomorphine CTD 2.013E-5 9.358E-4 7.434E-3 3.182E-2 2 27
35 ctd:C015854 estradiol valerate CTD 2.167E-5 9.789E-4 7.776E-3 3.426E-2 2 28
36 CID000002803 clonidine Stitch 2.238E-5 9.831E-4 7.809E-3 3.539E-2 3 240
37 CID000001305 AC1L1B6K Stitch 2.493E-5 1.065E-3 8.463E-3 3.942E-2 2 30
38 ctd:D004966 Estrogens, Conjugated (USP) CTD 2.665E-5 1.109E-3 8.807E-3 4.213E-2 2 31
39 CID002724375 AC1MC4ST Stitch 3.408E-5 1.382E-3 1.098E-2
5.389E-2
 2 35
40 CID000005290 l-stepholidine Stitch 3.608E-5 1.391E-3 1.105E-2
5.705E-2
 2 36
41 CID000086137 Pulsar Stitch 3.608E-5 1.391E-3 1.105E-2
5.705E-2
 2 36
42 CID000000853 thryroxine Stitch 4.444E-5 1.613E-3 1.282E-2
7.026E-2
 3 302
43 ctd:D001971 Bromocriptine CTD 4.466E-5 1.613E-3 1.282E-2
7.060E-2
 2 40
44 ctd:C080417 4-octylphenol CTD 4.694E-5 1.613E-3 1.282E-2
7.421E-2
 2 41
45 ctd:D011397 Promegestone CTD 4.694E-5 1.613E-3 1.282E-2
7.421E-2
 2 41
46 ctd:D013469 Sulpiride CTD 4.694E-5 1.613E-3 1.282E-2
7.421E-2
 2 41
47 ctd:D015282 Octreotide CTD 5.168E-5 1.707E-3 1.356E-2
8.171E-2
 2 43
48 ctd:D005576 Colforsin CTD 5.183E-5 1.707E-3 1.356E-2
8.194E-2
 3 318
49 CID005464109 I06-1821 Stitch 5.665E-5 1.756E-3 1.395E-2
8.956E-2
 2 45
50 CID000163897 GH 5 Stitch 5.665E-5 1.756E-3 1.395E-2
8.956E-2
 2 45
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 486 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0342388 Adrenocorticotropic hormone (ACTH) deficiency (disorder) DisGeNET Curated 8.055E-9 3.101E-6 2.098E-5 3.915E-6 3 13
2 C0271801 Central hypothyroidism DisGeNET Curated 1.281E-8 3.101E-6 2.098E-5 6.226E-6 3 15
3 C3665349 Secondary hypothyroidism DisGeNET Curated 1.914E-8 3.101E-6 2.098E-5 9.303E-6 3 17
4 C0013338 Pituitary dwarfism DisGeNET Curated 8.222E-8 9.990E-6 6.758E-5 3.996E-5 3 27
5 C0020635 Hypopituitarism DisGeNET Curated 1.532E-7 1.489E-5 1.007E-4 7.448E-5 3 33
6 C0242343 Panhypopituitarism DisGeNET Curated 1.838E-7 1.489E-5 1.007E-4 8.932E-5 3 35
7 C0271789 Hypothyroidism, Congenital, Nongoitrous, 4 DisGeNET Curated 6.853E-7 4.758E-5 3.218E-4 3.330E-4 2 4
8 C0271623 Hypogonadotropic hypogonadism DisGeNET Curated 4.499E-6 2.733E-4 1.849E-3 2.187E-3 3 100
9 C0206042 Fatal Familial Insomnia DisGeNET Curated 6.274E-6 3.388E-4 2.292E-3 3.049E-3 2 11
10 C4053775 Pituitary stalk interruption syndrome DisGeNET Curated 8.895E-6 3.930E-4 2.658E-3 4.323E-3 2 13
11 C0017547 Gigantism DisGeNET BeFree 8.895E-6 3.930E-4 2.658E-3 4.323E-3 2 13
12 C0020514 Hyperprolactinemia DisGeNET Curated 1.550E-5 6.277E-4 4.246E-3 7.533E-3 2 17
13 C0948740 Pituitary hypoplasia DisGeNET Curated 1.743E-5 6.518E-4 4.409E-3 8.473E-3 2 18
14 C0020676 Hypothyroidism DisGeNET Curated 2.178E-5 7.560E-4 5.114E-3 1.058E-2 3 169
15 C1512981 Mammary Tumorigenesis DisGeNET BeFree 2.501E-5 8.104E-4 5.482E-3 1.216E-2 3 177
16 C0001787 Osteoporosis, Age-Related DisGeNET BeFree 3.142E-5 8.982E-4 6.076E-3 1.527E-2 2 24
17 C0338503 Septo-Optic Dysplasia DisGeNET Curated 3.142E-5 8.982E-4 6.076E-3 1.527E-2 2 24
18 C0266013 Congenital hypoplasia of breast DisGeNET Curated 3.698E-5 9.460E-4 6.399E-3 1.797E-2 2 26
19 C0030779 Pelger-Huet Anomaly DisGeNET Curated 3.698E-5 9.460E-4 6.399E-3 1.797E-2 2 26
20 C0020615 Hypoglycemia DisGeNET Curated 4.169E-5 9.952E-4 6.732E-3 2.026E-2 3 210
21 C0018979 Hemianopsia DisGeNET Curated 4.300E-5 9.952E-4 6.732E-3 2.090E-2 2 28
22 C0406810 Carney Complex DisGeNET Curated 5.287E-5 1.168E-3 7.901E-3 2.570E-2 2 31
23 C0346302 Growth Hormone-Secreting Pituitary Adenoma DisGeNET Curated 7.157E-5 1.512E-3 1.023E-2 3.479E-2 2 36
24 C0032019 Pituitary Neoplasms DisGeNET Curated 8.718E-5 1.765E-3 1.194E-2 4.237E-2 3 269
25 C0175693 Russell-Silver syndrome DisGeNET Curated 1.279E-4 2.391E-3 1.617E-2
6.216E-2
 2 48
26 C0221406 Pituitary-dependent Cushing's disease DisGeNET Curated 1.279E-4 2.391E-3 1.617E-2
6.216E-2
 2 48
27 C0740858 Substance abuse problem DisGeNET Curated 1.389E-4 2.434E-3 1.647E-2
6.748E-2
 2 50
28 C1257930 Mammary Carcinoma, Human DisGeNET BeFree 1.445E-4 2.434E-3 1.647E-2
7.022E-2
 2 51
29 C3714796 Isolated somatotropin deficiency DisGeNET Curated 1.503E-4 2.434E-3 1.647E-2
7.302E-2
 2 52
30 C0086942 Rous Sarcoma DisGeNET BeFree 1.503E-4 2.434E-3 1.647E-2
7.302E-2
 2 52
31 C0029456 Osteoporosis DisGeNET Curated 2.353E-4 3.434E-3 2.323E-2
1.143E-1
 3 376
32 C0001206 Acromegaly DisGeNET Curated 2.887E-4 3.434E-3 2.323E-2
1.403E-1
 2 72
33 cv:C0342573 Ateleiotic dwarfism Clinical Variations 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
34 cv:C0338503 Septo-optic dysplasia sequence Clinical Variations 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
35 OMIN:182230 SEPTOOPTIC DYSPLASIA OMIM 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
36 cv:C1849779 Kowarski syndrome Clinical Variations 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
37 OMIN:262650 KOWARSKI SYNDROME OMIM 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
38 C0599725 colon growth DisGeNET BeFree 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
39 C0034040 Puerperal Disorders DisGeNET Curated 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
40 OMIN:173100 ISOLATED GROWTH HORMONE DEFICIENCY, TYPE II; IGHD2 OMIM 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
41 C2930844 Hypopituitarism and septooptic 'dysplasia' DisGeNET Curated 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
42 C1849779 Kowarski syndrome DisGeNET Curated 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
43 C2960725 Invasive pituitary adenoma DisGeNET BeFree 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
44 C3149931 PALMOPLANTAR HYPERKERATOSIS WITH SQUAMOUS CELL CARCINOMA OF SKIN AND 46,XX SEX REVERSAL DisGeNET Curated 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
45 cv:C0271567 Autosomal dominant isolated somatotropin deficiency Clinical Variations 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
46 OMIN:262400 ISOLATED GROWTH HORMONE DEFICIENCY, TYPE IA; IGHD1A OMIM 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
47 OMIN:610644 PALMOPLANTAR HYPERKERATOSIS WITH SQUAMOUS CELL CARCINOMA OF SKIN AND SEX REVERSAL OMIM 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
48 cv:C3149931 Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and 46,XX sex reversal Clinical Variations 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
49 C0235660 Galactorrhea not associated with childbirth DisGeNET BeFree 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
50 C0269995 Galactorrhea associated with childbirth DisGeNET BeFree 3.703E-4 3.434E-3 2.323E-2
1.799E-1
 1 1
Show 45 more annotations