Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc313_11, positive side

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1: GO: Molecular Function [Display Chart] 11 input genes in category / 36 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003743 translation initiation factor activity 2.867E-19 1.032E-17 4.309E-17 1.032E-17 8 51
2 GO:0008135 translation factor activity, RNA binding 3.471E-17 6.248E-16 2.608E-15 1.250E-15 8 90
3 GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity 1.894E-6 2.273E-5 9.489E-5 6.819E-5 2 4
4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses 1.732E-5 1.247E-4 5.207E-4 6.237E-4 2 11
5 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 1.732E-5 1.247E-4 5.207E-4 6.237E-4 2 11
6 GO:0043021 ribonucleoprotein complex binding 4.121E-5 2.473E-4 1.032E-3 1.484E-3 3 120
7 GO:0031369 translation initiation factor binding 1.860E-4 8.858E-4 3.698E-3 6.695E-3 2 35
8 GO:0051879 Hsp90 protein binding 1.969E-4 8.858E-4 3.698E-3 7.087E-3 2 36
9 GO:0043022 ribosome binding 4.446E-4 1.660E-3 6.931E-3 1.600E-2 2 54
10 GO:0016860 intramolecular oxidoreductase activity 4.612E-4 1.660E-3 6.931E-3 1.660E-2 2 55
11 GO:0005085 guanyl-nucleotide exchange factor activity 6.534E-4 2.138E-3 8.927E-3 2.352E-2 3 306
12 GO:0005525 GTP binding 1.206E-3 3.617E-3 1.510E-2 4.340E-2 3 378
13 GO:0032561 guanyl ribonucleotide binding 1.409E-3 3.649E-3 1.523E-2
5.072E-2
 3 399
14 GO:0019001 guanyl nucleotide binding 1.419E-3 3.649E-3 1.523E-2
5.108E-2
 3 400
15 GO:0031072 heat shock protein binding 1.700E-3 4.080E-3 1.703E-2
6.121E-2
 2 106
16 GO:0071074 eukaryotic initiation factor eIF2 binding 2.356E-3 5.301E-3 2.213E-2
8.481E-2
 1 4
17 GO:0016853 isomerase activity 4.299E-3 9.104E-3 3.801E-2
1.548E-1
 2 170
18 GO:0004713 protein tyrosine kinase activity 4.910E-3 9.821E-3 4.100E-2
1.768E-1
 2 182
19 GO:0043023 ribosomal large subunit binding 5.294E-3 1.003E-2 4.187E-2
1.906E-1
 1 9
20 GO:0043422 protein kinase B binding 8.809E-3 1.586E-2
6.619E-2
3.171E-1
 1 15
21 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1.348E-2 2.311E-2
9.645E-2
4.852E-1
 1 23
22 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2.679E-2 4.277E-2
1.786E-1
9.645E-1
 1 46
23 GO:0004674 protein serine/threonine kinase activity 2.786E-2 4.277E-2
1.786E-1
1.000E0
 2 452
24 GO:0000049 tRNA binding 2.852E-2 4.277E-2
1.786E-1
1.000E0
 1 49
25 GO:0019003 GDP binding 3.424E-2 4.931E-2
2.058E-1
1.000E0
 1 59
Show 20 more annotations

2: GO: Biological Process [Display Chart] 11 input genes in category / 376 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006413 translational initiation 1.299E-19 4.884E-17 3.179E-16 4.884E-17 10 194
2 GO:0006446 regulation of translational initiation 3.186E-12 5.990E-10 3.898E-9 1.198E-9 6 84
3 GO:0010608 posttranscriptional regulation of gene expression 2.607E-11 3.268E-9 2.127E-8 9.803E-9 8 475
4 GO:0043558 regulation of translational initiation in response to stress 2.007E-10 1.709E-8 1.112E-7 7.547E-8 4 18
5 GO:0006417 regulation of translation 2.273E-10 1.709E-8 1.112E-7 8.545E-8 7 347
6 GO:0034248 regulation of cellular amide metabolic process 4.288E-10 2.574E-8 1.675E-7 1.612E-7 7 380
7 GO:0043555 regulation of translation in response to stress 4.792E-10 2.574E-8 1.675E-7 1.802E-7 4 22
8 GO:0032057 negative regulation of translational initiation in response to stress 5.359E-9 2.519E-7 1.639E-6 2.015E-6 3 7
9 GO:0032055 negative regulation of translation in response to stress 1.285E-8 5.370E-7 3.495E-6 4.833E-6 3 9
10 GO:0042594 response to starvation 2.641E-8 9.931E-7 6.463E-6 9.931E-6 5 170
11 GO:0009266 response to temperature stimulus 1.360E-7 4.649E-6 3.026E-5 5.114E-5 5 236
12 GO:0045947 negative regulation of translational initiation 2.346E-7 7.352E-6 4.785E-5 8.823E-5 3 22
13 GO:0034198 cellular response to amino acid starvation 4.450E-7 1.287E-5 8.376E-5 1.673E-4 3 27
14 GO:1990928 response to amino acid starvation 9.513E-7 2.235E-5 1.455E-4 3.577E-4 2 3
15 GO:1990737 response to manganese-induced endoplasmic reticulum stress 9.513E-7 2.235E-5 1.455E-4 3.577E-4 2 3
16 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity 9.513E-7 2.235E-5 1.455E-4 3.577E-4 2 3
17 GO:0017148 negative regulation of translation 1.115E-6 2.467E-5 1.605E-4 4.193E-4 4 145
18 GO:0014003 oligodendrocyte development 1.279E-6 2.671E-5 1.738E-4 4.808E-4 3 38
19 GO:0034249 negative regulation of cellular amide metabolic process 1.419E-6 2.807E-5 1.827E-4 5.334E-4 4 154
20 GO:0006984 ER-nucleus signaling pathway 1.868E-6 3.511E-5 2.285E-4 7.023E-4 3 43
21 GO:0009408 response to heat 2.154E-6 3.856E-5 2.510E-4 8.099E-4 4 171
22 GO:1905097 regulation of guanyl-nucleotide exchange factor activity 3.169E-6 5.416E-5 3.525E-4 1.191E-3 2 5
23 GO:0019509 L-methionine salvage from methylthioadenosine 8.864E-6 1.449E-4 9.431E-4 3.333E-3 2 8
24 GO:0071501 cellular response to sterol depletion 1.139E-5 1.714E-4 1.115E-3 4.284E-3 2 9
25 GO:0032933 SREBP signaling pathway 1.139E-5 1.714E-4 1.115E-3 4.284E-3 2 9
26 GO:0034976 response to endoplasmic reticulum stress 1.223E-5 1.727E-4 1.124E-3 4.597E-3 4 265
27 GO:0071267 L-methionine salvage 1.424E-5 1.727E-4 1.124E-3 5.353E-3 2 10
28 GO:0043102 amino acid salvage 1.424E-5 1.727E-4 1.124E-3 5.353E-3 2 10
29 GO:0071287 cellular response to manganese ion 1.424E-5 1.727E-4 1.124E-3 5.353E-3 2 10
30 GO:0071265 L-methionine biosynthetic process 1.424E-5 1.727E-4 1.124E-3 5.353E-3 2 10
31 GO:0006991 response to sterol depletion 1.424E-5 1.727E-4 1.124E-3 5.353E-3 2 10
32 GO:0021782 glial cell development 1.693E-5 1.990E-4 1.295E-3 6.367E-3 3 89
33 GO:0048709 oligodendrocyte differentiation 1.996E-5 2.274E-4 1.480E-3 7.503E-3 3 94
34 GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 2.087E-5 2.308E-4 1.502E-3 7.846E-3 2 12
35 GO:0009086 methionine biosynthetic process 3.317E-5 3.563E-4 2.319E-3 1.247E-2 2 15
36 GO:0042552 myelination 4.250E-5 4.416E-4 2.874E-3 1.598E-2 3 121
37 GO:0007272 ensheathment of neurons 4.463E-5 4.416E-4 2.874E-3 1.678E-2 3 123
38 GO:0008366 axon ensheathment 4.463E-5 4.416E-4 2.874E-3 1.678E-2 3 123
39 GO:0010042 response to manganese ion 4.828E-5 4.538E-4 2.954E-3 1.815E-2 2 18
40 GO:0006555 methionine metabolic process 4.828E-5 4.538E-4 2.954E-3 1.815E-2 2 18
41 GO:0009267 cellular response to starvation 5.027E-5 4.610E-4 3.000E-3 1.890E-2 3 128
42 GO:0030968 endoplasmic reticulum unfolded protein response 5.264E-5 4.713E-4 3.067E-3 1.979E-2 3 130
43 GO:0034620 cellular response to unfolded protein 5.635E-5 4.927E-4 3.207E-3 2.119E-2 3 133
44 GO:0036499 PERK-mediated unfolded protein response 5.992E-5 5.120E-4 3.332E-3 2.253E-2 2 20
45 GO:0000097 sulfur amino acid biosynthetic process 6.620E-5 5.481E-4 3.567E-3 2.489E-2 2 21
46 GO:0035967 cellular response to topologically incorrect protein 6.705E-5 5.481E-4 3.567E-3 2.521E-2 3 141
47 GO:0051099 positive regulation of binding 8.384E-5 6.707E-4 4.365E-3 3.152E-2 3 152
48 GO:0009067 aspartate family amino acid biosynthetic process 8.693E-5 6.809E-4 4.431E-3 3.268E-2 2 24
49 GO:0006986 response to unfolded protein 1.252E-4 9.606E-4 6.252E-3 4.707E-2 3 174
50 GO:0031669 cellular response to nutrient levels 1.384E-4 1.041E-3 6.773E-3
5.204E-2
 3 180
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 11 input genes in category / 26 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005850 eukaryotic translation initiation factor 2 complex 6.002E-14 1.560E-12 6.015E-12 1.560E-12 4 4
2 GO:0005851 eukaryotic translation initiation factor 2B complex 8.997E-13 1.170E-11 4.508E-11 2.339E-11 4 6
3 GO:1990565 HSP90-CDC37 chaperone complex 5.771E-4 3.001E-3 1.157E-2 1.500E-2 1 1
4 GO:0043614 multi-eIF complex 5.771E-4 3.001E-3 1.157E-2 1.500E-2 1 1
5 GO:0044207 translation initiation ternary complex 5.771E-4 3.001E-3 1.157E-2 1.500E-2 1 1
6 GO:0097451 glial limiting end-foot 1.730E-3 7.498E-3 2.890E-2 4.499E-2 1 3
7 GO:0097450 astrocyte end-foot 2.882E-3 1.071E-2 4.127E-2
7.494E-2
 1 5
8 GO:0097449 astrocyte projection 7.479E-3 2.174E-2
8.379E-2
1.944E-1
 1 13
9 GO:0005840 ribosome 7.736E-3 2.174E-2
8.379E-2
2.011E-1
 2 235
10 GO:0033290 eukaryotic 48S preinitiation complex 8.625E-3 2.174E-2
8.379E-2
2.242E-1
 1 15
11 GO:0070993 translation preinitiation complex 9.197E-3 2.174E-2
8.379E-2
2.391E-1
 1 16
12 GO:0097386 glial cell projection 1.034E-2 2.241E-2
8.636E-2
2.689E-1
 1 18
13 GO:0010494 cytoplasmic stress granule 1.945E-2 3.890E-2
1.500E-1
5.058E-1
 1 34
Show 8 more annotations

4: Human Phenotype [Display Chart] 6 input genes in category / 369 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000241 Deceleration of head growth 1.150E-8 1.061E-6 6.886E-6 4.245E-6 3 5
2 HP:0004485 Cessation of head growth 1.150E-8 1.061E-6 6.886E-6 4.245E-6 3 5
3 HP:0031212 Abnormal circulating progesterone level 1.150E-8 1.061E-6 6.886E-6 4.245E-6 3 5
4 HP:0008233 Decreased circulating progesterone 1.150E-8 1.061E-6 6.886E-6 4.245E-6 3 5
5 HP:0006808 Cerebral hypomyelination 1.107E-6 6.809E-5 4.419E-4 4.086E-4 3 19
6 HP:0008193 Primary gonadal insufficiency 1.107E-6 6.809E-5 4.419E-4 4.086E-4 3 19
7 HP:0000746 Delusions 3.391E-6 1.687E-4 1.095E-3 1.251E-3 4 105
8 HP:0000751 Personality changes 3.658E-6 1.687E-4 1.095E-3 1.350E-3 4 107
9 HP:0002354 Memory impairment 1.492E-5 6.115E-4 3.968E-3 5.504E-3 4 152
10 HP:0008209 Premature ovarian insufficiency 2.485E-5 9.171E-4 5.952E-3 9.171E-3 3 52
11 HP:0000869 Secondary amenorrhea 3.460E-5 1.144E-3 7.423E-3 1.277E-2 3 58
12 HP:0002317 Unsteady gait 3.776E-5 1.144E-3 7.423E-3 1.393E-2 4 192
13 HP:0007305 CNS demyelination 4.030E-5 1.144E-3 7.423E-3 1.487E-2 3 61
14 HP:0003429 CNS hypomyelination 5.112E-5 1.347E-3 8.743E-3 1.886E-2 3 66
15 HP:0005484 Postnatal microcephaly 6.643E-5 1.634E-3 1.060E-2 2.451E-2 3 72
16 HP:0031066 Abnormal ovarian physiology 8.778E-5 2.025E-3 1.314E-2 3.239E-2 3 79
17 HP:0004335 Abnormal formation of myelin sheaths 9.462E-5 2.054E-3 1.333E-2 3.491E-2 3 81
18 HP:0000712 Emotional lability 2.174E-4 4.456E-3 2.892E-2
8.021E-2
 3 107
19 HP:0100705 Abnormality of the glial cells 4.962E-4 9.637E-3
6.254E-2
1.831E-1
 4 370
20 HP:0001296 Mood alterations 5.570E-4 1.028E-2
6.669E-2
2.056E-1
 3 147
21 HP:0000141 Amenorrhea 7.149E-4 1.256E-2
8.152E-2
2.638E-1
 3 160
22 HP:0002352 Leukoencephalopathy 7.688E-4 1.289E-2
8.368E-2
2.837E-1
 3 164
23 HP:0001254 Lethargy 9.458E-4 1.517E-2
9.847E-2
3.490E-1
 3 176
24 HP:0003381 Demyelination 1.077E-3 1.622E-2
1.053E-1
3.975E-1
 3 184
25 HP:0001260 Dysarthria 1.103E-3 1.622E-2
1.053E-1
4.072E-1
 4 455
26 HP:0010168 Ivory epiphyses of the toes 1.275E-3 1.622E-2
1.053E-1
4.704E-1
 1 1
27 HP:0008134 Irregular tarsal ossification 1.275E-3 1.622E-2
1.053E-1
4.704E-1
 1 1
28 HP:0010160 Abnormality of the epiphyses of the toes 1.275E-3 1.622E-2
1.053E-1
4.704E-1
 1 1
29 HP:0010631 Abnormality of the epiphyses of the feet 1.275E-3 1.622E-2
1.053E-1
4.704E-1
 1 1
30 HP:0011400 Abnormal CNS myelination 1.862E-3 2.291E-2
1.486E-1
6.872E-1
 3 222
31 HP:0000618 Blindness 2.507E-3 2.849E-2
1.849E-1
9.252E-1
 3 246
32 HP:0007229 Intracerebral periventricular calcifications 2.548E-3 2.849E-2
1.849E-1
9.402E-1
 1 2
33 HP:0400000 Tall chin 2.548E-3 2.849E-2
1.849E-1
9.402E-1
 1 2
34 HP:0002376 Developmental regression 3.604E-3 3.820E-2
2.479E-1
1.000E0
 3 279
35 HP:0002520 Abnormal myelination 3.641E-3 3.820E-2
2.479E-1
1.000E0
 3 280
36 HP:0004236 Irregular carpal bones 3.820E-3 3.820E-2
2.479E-1
1.000E0
 1 3
37 HP:0000137 Abnormality of the ovary 3.831E-3 3.820E-2
2.479E-1
1.000E0
 3 285
38 HP:0006014 Abnormally shaped carpal bones 5.091E-3 4.817E-2
3.126E-1
1.000E0
 1 4
39 HP:0010234 Ivory epiphyses of the phalanges of the hand 5.091E-3 4.817E-2
3.126E-1
1.000E0
 1 4
Show 34 more annotations

5: Mouse Phenotype [Display Chart] 8 input genes in category / 178 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 11 input genes in category / 86 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR000649 IF-2B-related InterPro 1.879E-6 8.081E-5 4.071E-4 1.616E-4 2 4
2 PF01008 IF-2B Pfam 1.879E-6 8.081E-5 4.071E-4 1.616E-4 2 4
3 PF03234 CDC37 N Pfam 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
4 PF09173 eIF2 C Pfam 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
5 IPR015256 TIF2 gsu C InterPro 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
6 IPR011387 TIF2A InterPro 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
7 1.10.150.190 - Gene3D 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
8 IPR011488 TIF 2 asu InterPro 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
9 3.30.70.1130 - Gene3D 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
10 SM01071 CDC37 N SMART 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
11 IPR033366 PKR InterPro 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
12 IPR013873 Cdc37 C InterPro 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
13 PF08564 CDC37 C Pfam 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
14 IPR013855 Cdc37 N dom InterPro 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
15 SM01069 CDC37 C SMART 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
16 PF07541 EIF 2 alpha Pfam 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
17 IPR024055 TIF2 asu C InterPro 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
18 IPR024054 TIF2 asu middle InterPro 5.871E-4 2.805E-3 1.413E-2
5.049E-2
 1 1
19 IPR012340 NA-bd OB-fold InterPro 1.064E-3 3.365E-3 1.695E-2
9.152E-2
 2 84
20 IPR004918 Cdc37 InterPro 1.174E-3 3.365E-3 1.695E-2
1.010E-1
 1 2
21 IPR013874 Cdc37 Hsp90-bd InterPro 1.174E-3 3.365E-3 1.695E-2
1.010E-1
 1 2
22 SM01070 CDC37 M SMART 1.174E-3 3.365E-3 1.695E-2
1.010E-1
 1 2
23 IPR010921 Trp repressor/repl initiator InterPro 1.174E-3 3.365E-3 1.695E-2
1.010E-1
 1 2
24 SM00653 eIF2B 5 SMART 1.174E-3 3.365E-3 1.695E-2
1.010E-1
 1 2
25 PF08565 CDC37 M Pfam 1.174E-3 3.365E-3 1.695E-2
1.010E-1
 1 2
26 IPR016190 Transl init fac IF2/IF5 Zn-bd InterPro 1.174E-3 3.365E-3 1.695E-2
1.010E-1
 1 2
27 PF01873 eIF-5 eIF-2B Pfam 1.174E-3 3.365E-3 1.695E-2
1.010E-1
 1 2
28 IPR016189 Transl init fac IF2/IF5 N InterPro 1.174E-3 3.365E-3 1.695E-2
1.010E-1
 1 2
29 3.30.30.50 - Gene3D 1.174E-3 3.365E-3 1.695E-2
1.010E-1
 1 2
30 IPR002735 Transl init fac IF2/IF5 InterPro 1.174E-3 3.365E-3 1.695E-2
1.010E-1
 1 2
31 IPR018104 TIF eIF-1A CS InterPro 1.760E-3 4.884E-3 2.460E-2
1.514E-1
 1 3
32 PD005579 TIF eIF-1A ProDom 2.347E-3 5.865E-3 2.954E-2
2.018E-1
 1 4
33 IPR011004 Trimer LpxA-like InterPro 2.347E-3 5.865E-3 2.954E-2
2.018E-1
 1 4
34 PS01262 IF1A PROSITE 2.347E-3 5.865E-3 2.954E-2
2.018E-1
 1 4
35 IPR006196 RNA-binding domain S1 IF1 InterPro 2.933E-3 5.865E-3 2.954E-2
2.522E-1
 1 5
36 PF08662 eIF2A Pfam 2.933E-3 5.865E-3 2.954E-2
2.522E-1
 1 5
37 IPR001451 Hexapep InterPro 2.933E-3 5.865E-3 2.954E-2
2.522E-1
 1 5
38 PF01176 eIF-1a Pfam 2.933E-3 5.865E-3 2.954E-2
2.522E-1
 1 5
39 IPR001253 TIF eIF-1A InterPro 2.933E-3 5.865E-3 2.954E-2
2.522E-1
 1 5
40 IPR013979 TIF beta prop-like InterPro 2.933E-3 5.865E-3 2.954E-2
2.522E-1
 1 5
41 PS50832 S1 IF1 TYPE PROSITE 2.933E-3 5.865E-3 2.954E-2
2.522E-1
 1 5
42 SM00652 eIF1a SMART 2.933E-3 5.865E-3 2.954E-2
2.522E-1
 1 5
43 PF00132 Hexapep Pfam 2.933E-3 5.865E-3 2.954E-2
2.522E-1
 1 5
44 2.140.10.10 - Gene3D 3.518E-3 6.724E-3 3.387E-2
3.026E-1
 1 6
45 IPR027295 Quinoprotein ADH-like fam InterPro 3.518E-3 6.724E-3 3.387E-2
3.026E-1
 1 6
46 PS51363 W2 PROSITE 4.103E-3 7.202E-3 3.628E-2
3.529E-1
 1 7
47 IPR003307 W2 domain InterPro 4.103E-3 7.202E-3 3.628E-2
3.529E-1
 1 7
48 PF02020 W2 Pfam 4.103E-3 7.202E-3 3.628E-2
3.529E-1
 1 7
49 SM00515 eIF5C SMART 4.103E-3 7.202E-3 3.628E-2
3.529E-1
 1 7
50 PF00575 S1 Pfam 4.688E-3 8.064E-3 4.062E-2
4.032E-1
 1 8
Show 45 more annotations

7: Pathway [Display Chart] 11 input genes in category / 60 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1268687 Recycling of eIF2:GDP BioSystems: REACTOME 2.502E-18 1.501E-16 7.026E-16 1.501E-16 6 8
2 M6924 Regulation of eIF2 MSigDB C2 BIOCARTA (v6.0) 4.125E-17 1.115E-15 5.217E-15 2.475E-15 6 11
3 M12975 VEGF, Hypoxia, and Angiogenesis MSigDB C2 BIOCARTA (v6.0) 5.574E-17 1.115E-15 5.217E-15 3.344E-15 7 29
4 1268680 Cap-dependent Translation Initiation BioSystems: REACTOME 3.104E-12 3.725E-11 1.743E-10 1.862E-10 7 127
5 1268679 Eukaryotic Translation Initiation BioSystems: REACTOME 3.104E-12 3.725E-11 1.743E-10 1.862E-10 7 127
6 1268678 Translation BioSystems: REACTOME 1.995E-11 1.995E-10 9.338E-10 1.197E-9 7 165
7 177876 RNA transport BioSystems: KEGG 2.570E-11 2.203E-10 1.031E-9 1.542E-9 7 171
8 M7721 Eukaryotic protein translation MSigDB C2 BIOCARTA (v6.0) 5.970E-10 4.478E-9 2.095E-8 3.582E-8 4 16
9 M16991 Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway MSigDB C2 BIOCARTA (v6.0) 1.586E-9 1.058E-8 4.950E-8 9.519E-8 4 20
10 M10570 Double Stranded RNA Induced Gene Expression MSigDB C2 BIOCARTA (v6.0) 6.137E-8 3.682E-7 1.723E-6 3.682E-6 3 10
11 1268682 Formation of the ternary complex, and subsequently, the 43S complex BioSystems: REACTOME 1.099E-7 5.996E-7 2.806E-6 6.596E-6 4 55
12 1268685 Ribosomal scanning and start codon recognition BioSystems: REACTOME 1.913E-7 9.310E-7 4.357E-6 1.148E-5 4 63
13 1268684 Translation initiation complex formation BioSystems: REACTOME 2.040E-7 9.310E-7 4.357E-6 1.224E-5 4 64
14 1268683 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S BioSystems: REACTOME 2.172E-7 9.310E-7 4.357E-6 1.303E-5 4 65
15 1268686 GTP hydrolysis and joining of the 60S ribosomal subunit BioSystems: REACTOME 2.486E-6 9.324E-6 4.364E-5 1.492E-4 4 119
16 1268688 L13a-mediated translational silencing of Ceruloplasmin expression BioSystems: REACTOME 2.486E-6 9.324E-6 4.364E-5 1.492E-4 4 119
17 1269904 ABC-family proteins mediated transport BioSystems: REACTOME 1.052E-4 3.712E-4 1.737E-3 6.310E-3 3 110
18 173973 Hepatitis C BioSystems: KEGG 1.766E-4 5.887E-4 2.755E-3 1.060E-2 3 131
19 213306 Measles BioSystems: KEGG 1.889E-4 5.964E-4 2.791E-3 1.133E-2 3 134
20 1268761 PERK regulates gene expression BioSystems: REACTOME 3.046E-4 9.138E-4 4.276E-3 1.828E-2 2 30
21 167325 Protein processing in endoplasmic reticulum BioSystems: KEGG 3.551E-4 1.014E-3 4.747E-3 2.130E-2 3 166
22 217173 Influenza A BioSystems: KEGG 4.008E-4 1.093E-3 5.116E-3 2.405E-2 3 173
23 377873 Herpes simplex infection BioSystems: KEGG 4.879E-4 1.273E-3 5.956E-3 2.927E-2 3 185
24 1269135 Inhibition of PKR BioSystems: REACTOME 8.835E-4 2.209E-3 1.034E-2
5.301E-2
 1 1
25 1268756 Unfolded Protein Response (UPR) BioSystems: REACTOME 2.906E-3 6.974E-3 3.264E-2
1.744E-1
 2 93
26 P00006 Apoptosis signaling pathway PantherDB 3.484E-3 8.039E-3 3.762E-2
2.090E-1
 2 102
27 83058 Autophagy - animal BioSystems: KEGG 5.429E-3 1.206E-2
5.646E-2
3.257E-1
 2 128
28 83060 Apoptosis BioSystems: KEGG 6.283E-3 1.346E-2
6.301E-2
3.770E-1
 2 138
29 862188 Non-alcoholic fatty liver disease (NAFLD) BioSystems: KEGG 7.290E-3 1.508E-2
7.059E-2
4.374E-1
 2 149
30 M2602 Bone Remodelling MSigDB C2 BIOCARTA (v6.0) 1.231E-2 2.461E-2
1.152E-1
7.383E-1
 1 14
31 585562 Epstein-Barr virus infection BioSystems: KEGG 1.321E-2 2.555E-2
1.196E-1
7.925E-1
 2 203
32 1268860 Constitutive Signaling by EGFRvIII BioSystems: REACTOME 1.405E-2 2.555E-2
1.196E-1
8.431E-1
 1 16
33 1268859 Signaling by EGFRvIII in Cancer BioSystems: REACTOME 1.405E-2 2.555E-2
1.196E-1
8.431E-1
 1 16
34 1268856 Signaling by EGFR in Cancer BioSystems: REACTOME 1.754E-2 2.923E-2
1.368E-1
1.000E0
 1 20
35 1268858 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants BioSystems: REACTOME 1.754E-2 2.923E-2
1.368E-1
1.000E0
 1 20
36 1268857 Signaling by Ligand-Responsive EGFR Variants in Cancer BioSystems: REACTOME 1.754E-2 2.923E-2
1.368E-1
1.000E0
 1 20
37 M3873 Apoptotic Signaling in Response to DNA Damage MSigDB C2 BIOCARTA (v6.0) 1.927E-2 3.126E-2
1.463E-1
1.000E0
 1 22
38 M11106 Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages MSigDB C2 BIOCARTA (v6.0) 2.361E-2 3.728E-2
1.744E-1
1.000E0
 1 27
39 1457793 Downregulation of ERBB2 signaling BioSystems: REACTOME 2.620E-2 4.031E-2
1.886E-1
1.000E0
 1 30
40 169350 Signaling events mediated by TCPTP BioSystems: Pathway Interaction Database 3.136E-2 4.590E-2
2.148E-1
1.000E0
 1 36
41 SMP00391 Insulin Signalling SMPDB 3.136E-2 4.590E-2
2.148E-1
1.000E0
 1 36
42 M984 Toll-Like Receptor Pathway MSigDB C2 BIOCARTA (v6.0) 3.222E-2 4.603E-2
2.154E-1
1.000E0
 1 37
43 1269131 NS1 Mediated Effects on Host Pathways BioSystems: REACTOME 3.479E-2 4.855E-2
2.272E-1
1.000E0
 1 40
44 137957 LKB1 signaling events BioSystems: Pathway Interaction Database 3.650E-2 4.867E-2
2.278E-1
1.000E0
 1 42
45 1269130 Host Interactions with Influenza Factors BioSystems: REACTOME 3.650E-2 4.867E-2
2.278E-1
1.000E0
 1 42
46 138023 Ceramide signaling pathway BioSystems: Pathway Interaction Database 3.821E-2 4.984E-2
2.332E-1
1.000E0
 1 44
Show 41 more annotations

8: Pubmed [Display Chart] 11 input genes in category / 1425 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16289705 An efficient mammalian cell-free translation system supplemented with translation factors. Pubmed 4.950E-20 7.054E-17 5.530E-16 7.054E-17 6 11
2 9446619 Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B. Pubmed 4.094E-18 2.917E-15 2.287E-14 5.833E-15 5 6
3 16288713 Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases. Pubmed 1.433E-17 6.805E-15 5.335E-14 2.041E-14 5 7
4 20434207 Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Pubmed 4.029E-17 1.435E-14 1.125E-13 5.742E-14 6 28
5 9079663 The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR. Pubmed 3.723E-15 8.841E-13 6.931E-12 5.305E-12 4 4
6 10620360 HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms. Pubmed 3.723E-15 8.841E-13 6.931E-12 5.305E-12 4 4
7 10805739 Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation. Pubmed 5.582E-14 8.839E-12 6.929E-11 7.955E-11 4 6
8 20660158 Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Pubmed 5.582E-14 8.839E-12 6.929E-11 7.955E-11 4 6
9 11323413 Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein. Pubmed 5.582E-14 8.839E-12 6.929E-11 7.955E-11 4 6
10 21385877 Dengue virus modulates the unfolded protein response in a time-dependent manner. Pubmed 2.604E-13 3.711E-11 2.909E-10 3.711E-10 4 8
11 12426392 Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. Pubmed 8.843E-12 1.146E-9 8.981E-9 1.260E-8 4 17
12 14993275 Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity. Pubmed 1.777E-11 1.407E-9 1.103E-8 2.532E-8 3 3
13 23063529 eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation. Pubmed 1.777E-11 1.407E-9 1.103E-8 2.532E-8 3 3
14 29036434 Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation. Pubmed 1.777E-11 1.407E-9 1.103E-8 2.532E-8 3 3
15 1104615 Binding of MET-TRNAf and GTP to homogeneous initiation factor MP. Pubmed 1.777E-11 1.407E-9 1.103E-8 2.532E-8 3 3
16 10648795 Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2. Pubmed 1.777E-11 1.407E-9 1.103E-8 2.532E-8 3 3
17 18052927 A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic beta-cells. Pubmed 1.777E-11 1.407E-9 1.103E-8 2.532E-8 3 3
18 1883206 Translational control in mammalian cells. Pubmed 1.777E-11 1.407E-9 1.103E-8 2.532E-8 3 3
19 14566705 eIF2B-related disorders: antenatal onset and involvement of multiple organs. Pubmed 7.107E-11 4.403E-9 3.452E-8 1.013E-7 3 4
20 22833567 Large G3BP-induced granules trigger eIF2α phosphorylation. Pubmed 7.107E-11 4.403E-9 3.452E-8 1.013E-7 3 4
21 18063576 PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation. Pubmed 7.107E-11 4.403E-9 3.452E-8 1.013E-7 3 4
22 8887689 Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2. Pubmed 7.107E-11 4.403E-9 3.452E-8 1.013E-7 3 4
23 19586904 The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2. Pubmed 7.107E-11 4.403E-9 3.452E-8 1.013E-7 3 4
24 15060152 Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways. Pubmed 1.777E-10 7.233E-9 5.670E-8 2.532E-7 3 5
25 20301435 Childhood Ataxia with Central Nervous System Hypomyelination/Vanishing White Matter Pubmed 1.777E-10 7.233E-9 5.670E-8 2.532E-7 3 5
26 15217090 The life and death of oligodendrocytes in vanishing white matter disease. Pubmed 1.777E-10 7.233E-9 5.670E-8 2.532E-7 3 5
27 20924113 eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}. Pubmed 1.777E-10 7.233E-9 5.670E-8 2.532E-7 3 5
28 10858531 Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation. Pubmed 1.777E-10 7.233E-9 5.670E-8 2.532E-7 3 5
29 18632786 No evidence that polymorphisms of the vanishing white matter disease genes are risk factors in multiple sclerosis. Pubmed 1.777E-10 7.233E-9 5.670E-8 2.532E-7 3 5
30 18263758 Genetic and clinical heterogeneity in eIF2B-related disorder. Pubmed 1.777E-10 7.233E-9 5.670E-8 2.532E-7 3 5
31 23000413 Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK, eIF2α phosphorylation, ATF4-dependent cascade. Pubmed 1.777E-10 7.233E-9 5.670E-8 2.532E-7 3 5
32 8626696 T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3. Pubmed 1.777E-10 7.233E-9 5.670E-8 2.532E-7 3 5
33 16176978 PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. Pubmed 1.777E-10 7.233E-9 5.670E-8 2.532E-7 3 5
34 12499492 A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation. Pubmed 1.777E-10 7.233E-9 5.670E-8 2.532E-7 3 5
35 12707859 Ovarian failure related to eukaryotic initiation factor 2B mutations. Pubmed 1.777E-10 7.233E-9 5.670E-8 2.532E-7 3 5
36 27698114 eIF2α phosphorylation controls thermal nociception. Pubmed 3.553E-10 1.332E-8 1.044E-7 5.062E-7 3 6
37 9819435 Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Pubmed 3.553E-10 1.332E-8 1.044E-7 5.062E-7 3 6
38 10542257 The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha. Pubmed 3.553E-10 1.332E-8 1.044E-7 5.062E-7 3 6
39 1677563 A synthetic peptide substrate for initiation factor-2 kinases. Pubmed 6.216E-10 2.271E-8 1.781E-7 8.858E-7 3 7
40 11555640 Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. Pubmed 9.944E-10 3.543E-8 2.777E-7 1.417E-6 3 8
41 12588972 Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region. Pubmed 1.082E-9 3.762E-8 2.949E-7 1.542E-6 4 53
42 12388085 Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. Pubmed 2.130E-9 7.227E-8 5.666E-7 3.036E-6 3 10
43 19139267 Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. Pubmed 3.137E-8 1.040E-6 8.151E-6 4.471E-5 3 23
44 18639529 Intersubunit and interprotein interactions of alpha- and beta-subunits of human eIF2: Effect of phosphorylation. Pubmed 7.541E-8 1.207E-6 9.466E-6 1.075E-4 2 2
45 22948139 Protein kinase PKR amplification of interferon β induction occurs through initiation factor eIF-2α-mediated translational control. Pubmed 7.541E-8 1.207E-6 9.466E-6 1.075E-4 2 2
46 21464971 Co-expression of miRNA targeting the expression of PERK, but not PKR, enhances cellular immunity from an HIV-1 Env DNA vaccine. Pubmed 7.541E-8 1.207E-6 9.466E-6 1.075E-4 2 2
47 16000157 PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia. Pubmed 7.541E-8 1.207E-6 9.466E-6 1.075E-4 2 2
48 21715487 Mammalian orthoreovirus escape from host translational shutoff correlates with stress granule disruption and is independent of eIF2alpha phosphorylation and PKR. Pubmed 7.541E-8 1.207E-6 9.466E-6 1.075E-4 2 2
49 19744687 The effect of the vaccinia K1 protein on the PKR-eIF2alpha pathway in RK13 and HeLa cells. Pubmed 7.541E-8 1.207E-6 9.466E-6 1.075E-4 2 2
50 15542627 Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR. Pubmed 7.541E-8 1.207E-6 9.466E-6 1.075E-4 2 2
Show 45 more annotations

9: Interaction [Display Chart] 11 input genes in category / 735 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:EIF2S1 EIF2S1 interactions 2.657E-19 1.953E-16 1.402E-15 1.953E-16 9 102
2 int:DCC DCC interactions 6.535E-14 2.402E-11 1.724E-10 4.803E-11 6 43
3 int:EIF2B4 EIF2B4 interactions 9.032E-11 2.213E-8 1.588E-7 6.638E-8 5 53
4 int:EIF2B3 EIF2B3 interactions 1.868E-10 3.243E-8 2.328E-7 1.373E-7 5 61
5 int:EIF2B1 EIF2B1 interactions 2.206E-10 3.243E-8 2.328E-7 1.621E-7 5 63
6 int:EIF2S2 EIF2S2 interactions 1.802E-9 2.207E-7 1.584E-6 1.324E-6 5 95
7 int:EIF2B5 EIF2B5 interactions 1.831E-8 1.922E-6 1.380E-5 1.346E-5 4 50
8 int:EIF5 EIF5 interactions 6.061E-8 5.568E-6 3.997E-5 4.455E-5 4 67
9 int:SMDT1 SMDT1 interactions 8.087E-8 6.605E-6 4.741E-5 5.944E-5 3 15
10 int:EIF2B2 EIF2B2 interactions 9.078E-8 6.672E-6 4.789E-5 6.672E-5 4 74
11 int:P2RX4 P2RX4 interactions 1.155E-6 7.718E-5 5.540E-4 8.493E-4 3 35
12 int:GPR183 GPR183 interactions 1.260E-6 7.718E-5 5.540E-4 9.262E-4 3 36
13 int:DLD DLD interactions 1.892E-6 1.070E-4 7.678E-4 1.391E-3 5 382
14 int:CA14 CA14 interactions 3.040E-6 1.596E-4 1.146E-3 2.234E-3 3 48
15 int:GYPB GYPB interactions 3.443E-6 1.687E-4 1.211E-3 2.530E-3 3 50
16 int:EIF2AK2 EIF2AK2 interactions 4.170E-6 1.915E-4 1.375E-3 3.065E-3 4 192
17 int:EIF2S3 EIF2S3 interactions 5.127E-6 2.147E-4 1.541E-3 3.769E-3 3 57
18 int:OPN3 OPN3 interactions 5.258E-6 2.147E-4 1.541E-3 3.865E-3 2 6
19 int:HDGF HDGF interactions 7.413E-6 2.868E-4 2.058E-3 5.449E-3 4 222
20 int:BZW2 BZW2 interactions 7.994E-6 2.928E-4 2.102E-3 5.876E-3 3 66
21 int:EIF3K EIF3K interactions 8.366E-6 2.928E-4 2.102E-3 6.149E-3 3 67
22 int:CYP1A1 CYP1A1 interactions 1.040E-5 3.474E-4 2.493E-3 7.642E-3 3 72
23 int:METAP2 METAP2 interactions 1.483E-5 4.739E-4 3.402E-3 1.090E-2 3 81
24 int:VTI1B VTI1B interactions 2.104E-5 6.393E-4 4.589E-3 1.547E-2 3 91
25 int:SUB1 SUB1 interactions 2.175E-5 6.393E-4 4.589E-3 1.598E-2 3 92
26 int:SIGLECL1 SIGLECL1 interactions 2.549E-5 7.205E-4 5.172E-3 1.873E-2 3 97
27 int:STX12 STX12 interactions 2.877E-5 7.832E-4 5.621E-3 2.115E-2 3 101
28 int:MAST3 MAST3 interactions 3.714E-5 9.750E-4 6.998E-3 2.730E-2 3 110
29 int:PTGER3 PTGER3 interactions 4.133E-5 1.047E-3 7.519E-3 3.038E-2 3 114
30 int:EIF2AK1 EIF2AK1 interactions 4.750E-5 1.164E-3 8.352E-3 3.491E-2 2 17
31 int:SPN SPN interactions 5.341E-5 1.266E-3 9.090E-3 3.926E-2 2 18
32 int:RPL10 RPL10 interactions 6.570E-5 1.509E-3 1.083E-2 4.829E-2 4 387
33 int:NECTIN4 NECTIN4 interactions 8.818E-5 1.964E-3 1.410E-2
6.481E-2
 2 23
34 int:DNAJC3 DNAJC3 interactions 9.616E-5 2.079E-3 1.492E-2
7.068E-2
 2 24
35 int:IKBKB IKBKB interactions 1.404E-4 2.883E-3 2.069E-2
1.032E-1
 3 172
36 int:THAP12 THAP12 interactions 1.412E-4 2.883E-3 2.069E-2
1.038E-1
 2 29
37 int:MCU MCU interactions 2.065E-4 4.103E-3 2.945E-2
1.518E-1
 2 35
38 int:QARS QARS interactions 2.358E-4 4.560E-3 3.273E-2
1.733E-1
 3 205
39 int:EIF1B EIF1B interactions 2.569E-4 4.841E-3 3.475E-2
1.888E-1
 2 39
40 int:EIF1AX EIF1AX interactions 3.274E-4 6.015E-3 4.318E-2
2.406E-1
 2 44
41 int:NCOA5 NCOA5 interactions 3.425E-4 6.139E-3 4.407E-2
2.517E-1
 2 45
42 int:EIF2AK3 EIF2AK3 interactions 3.737E-4 6.540E-3 4.694E-2
2.747E-1
 2 47
43 int:UPF1 UPF1 interactions 4.474E-4 7.648E-3
5.489E-2
3.288E-1
 3 255
44 int:CDC37 CDC37 interactions 4.843E-4 8.089E-3
5.806E-2
3.559E-1
 3 262
45 int:AIP AIP interactions 5.120E-4 8.127E-3
5.833E-2
3.763E-1
 2 55
46 int:CDCA5 CDCA5 interactions 5.120E-4 8.127E-3
5.833E-2
3.763E-1
 2 55
47 int:SYT1 SYT1 interactions 5.308E-4 8.127E-3
5.833E-2
3.901E-1
 2 56
48 int:CDK3 CDK3 interactions 5.308E-4 8.127E-3
5.833E-2
3.901E-1
 2 56
49 int:EIF2A EIF2A interactions 5.499E-4 8.248E-3
5.920E-2
4.042E-1
 2 57
50 int:ETF1 ETF1 interactions 5.891E-4 8.497E-3
6.099E-2
4.330E-1
 2 59
Show 45 more annotations

10: Cytoband [Display Chart] 11 input genes in category / 11 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Xp22.2-p22.1 Xp22.2-p22.1 1.586E-3 9.300E-3 2.808E-2 1.744E-2 1 5
2 2p22-p21 2p22-p21 2.536E-3 9.300E-3 2.808E-2 2.790E-2 1 8
3 Xp22.12 Xp22.12 2.536E-3 9.300E-3 2.808E-2 2.790E-2 1 8
4 20q11.2 20q11.2 8.537E-3 1.565E-2 4.726E-2
9.390E-2
 1 27
5 3q27.1 3q27.1 8.537E-3 1.565E-2 4.726E-2
9.390E-2
 1 27
6 14q23.3 14q23.3 8.537E-3 1.565E-2 4.726E-2
9.390E-2
 1 27
7 3q25.1 3q25.1 1.042E-2 1.638E-2 4.947E-2
1.147E-1
 1 33
8 12q24.31 12q24.31 2.541E-2 3.494E-2
1.055E-1
2.795E-1
 1 81
9 14q24.3 14q24.3 2.974E-2 3.635E-2
1.098E-1
3.272E-1
 1 95
10 2p12 2p12 3.652E-2 4.017E-2
1.213E-1
4.017E-1
 1 117
Show 5 more annotations

11: Transcription Factor Binding Site [Display Chart] 9 input genes in category / 36 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 2 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 694 Protein phosphatase 1 regulatory subunits genenames.org 9.843E-5 9.843E-5 9.843E-5 9.843E-5 2 181

13: Coexpression [Display Chart] 11 input genes in category / 1168 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M15671 Genes down-regulated in prostate cancer samples from African-American patients compared to those from the European-American patients. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.581E-6 6.047E-3 4.621E-2 1.002E-2 3 88
2 M459 Cluster 0: genes changed in primary keratinocytes by UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.544E-5 6.047E-3 4.621E-2 1.804E-2 3 107
3 M16091 Genes that escape X inactivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.598E-5 6.047E-3 4.621E-2 1.867E-2 2 13
4 M18086 'Cancer prone response profile' (CPRP): genes common to estradiol and bisphenol A [PubChem=5757;6623] response of epithelial cell cultures from patients at high risk of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.071E-5 6.047E-3 4.621E-2 2.419E-2 3 118
5 11861292-Table2 Human BoneMarrow Zhan02 30genes GeneSigDB 8.285E-5 1.059E-2
8.093E-2
9.677E-2
 2 29
6 M17405 Top genes up-regulated in MM4 vs MM1 subgroup of multiple myeloma samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.874E-5 1.059E-2
8.093E-2
1.037E-1
 2 30
7 M9132 Genes up-regulated in T reg: GATA1 [GeneID=2623] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 1.059E-2
8.093E-2
1.165E-1
 3 200
8 M5821 Genes up-regulated in comparison of naive CD8 T cells versus exhausted CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 1.059E-2
8.093E-2
1.165E-1
 3 200
9 M5926 A subgroup of genes regulated by MYC - version 1 (v1). MSigDB H: Hallmark Gene Sets (v6.0) 9.976E-5 1.059E-2
8.093E-2
1.165E-1
 3 200
10 M8089 Genes down-regulated in myeloid-derived suppressor cells from bone marrow: wildtype versus HDC [GeneID=3067] knockout. MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 1.059E-2
8.093E-2
1.165E-1
 3 200
11 M5833 Genes up-regulated in comparison of effector CD8 T cells versus exhausted CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 1.059E-2
8.093E-2
1.165E-1
 3 200
12 M10480 Integrin, VEGF, Wnt and TGFbeta signaling pathway genes down-regulated in PC-3 cells (prostate cancer) after knockdown of PDEF [GeneID=25803] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.508E-4 1.468E-2
1.122E-1
1.762E-1
 2 39
13 M6303 Genes encoding IkappaB kinase (IKK) interacting proteins. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.348E-4 3.008E-2
2.298E-1
3.910E-1
 2 58
14 M13936 Genes down-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.633E-4 3.866E-2
2.954E-1
5.412E-1
 3 337
15 M15130 Transcripts enriched in pseudopodia of NIH/3T3 cells (fibroblast) in response to the chemotactic migration stimulus by lysophosphatidic acid (LPA) [PubChem=3988]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.448E-4 4.242E-2
3.241E-1
6.363E-1
 2 74
Show 10 more annotations

14: Coexpression Atlas [Display Chart] 11 input genes in category / 375 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour Wilms PT-U/Kidney Tumour Wilms PT26 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour Wilms PT-U/Kidney Tumour Wilms PT26 Adult, Development, and Cancer types 1.115E-4 4.183E-2
2.721E-1
 4.183E-2 3 196

15: Computational [Display Chart] 10 input genes in category / 86 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M18480 MODULE 159 Translation regulation. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.834E-5 5.017E-3 2.527E-2 5.017E-3 3 81

16: MicroRNA [Display Chart] 11 input genes in category / 498 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-4777-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.783E-5 6.427E-3 4.363E-2 1.386E-2 2 52
2 hsa-miR-4778-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.970E-5 6.427E-3 4.363E-2 2.973E-2 2 76
3 hsa-miR-888-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.129E-5 6.427E-3 4.363E-2 3.052E-2 2 77
4 hsa-miR-4429:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.290E-5 6.427E-3 4.363E-2 3.132E-2 2 78
5 hsa-miR-320d:Functional MTI Functional MTI miRTarbase 6.453E-5 6.427E-3 4.363E-2 3.213E-2 2 79
6 hsa-miR-320c:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.207E-4 1.002E-2
6.802E-2
6.012E-2
 2 108
7 hsa-miR-320b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.175E-4 1.547E-2
1.050E-1
1.083E-1
 2 145
8 hsa-miR-8063:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.004E-4 1.906E-2
1.294E-1
1.994E-1
 2 197
9 hsa-miR-4726-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.126E-4 1.906E-2
1.294E-1
2.055E-1
 2 200
10 hsa-miR-4698:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.808E-4 1.906E-2
1.294E-1
2.394E-1
 2 216
11 hsa-miR-6881-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.260E-4 1.906E-2
1.294E-1
2.620E-1
 2 226
12 hsa-miR-877-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.684E-4 1.906E-2
1.294E-1
2.831E-1
 2 235
13 hsa-miR-6790-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.159E-4 1.906E-2
1.294E-1
4.063E-1
 2 282
14 hsa-miR-551a:mirSVR lowEffct hsa-miR-551a:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 8.274E-4 1.906E-2
1.294E-1
4.121E-1
 2 284
15 hsa-miR-6821-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.390E-4 1.906E-2
1.294E-1
4.178E-1
 2 286
16 hsa-miR-548am-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.683E-4 1.906E-2
1.294E-1
4.324E-1
 2 291
17 hsa-miR-548ah-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.683E-4 1.906E-2
1.294E-1
4.324E-1
 2 291
18 hsa-miR-548j-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.742E-4 1.906E-2
1.294E-1
4.354E-1
 2 292
19 hsa-miR-4282:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.801E-4 1.906E-2
1.294E-1
4.383E-1
 2 293
20 hsa-miR-548aq-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.801E-4 1.906E-2
1.294E-1
4.383E-1
 2 293
21 hsa-miR-548ae-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.801E-4 1.906E-2
1.294E-1
4.383E-1
 2 293
22 hsa-miR-548x-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.801E-4 1.906E-2
1.294E-1
4.383E-1
 2 293
23 hsa-miR-548aj-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.801E-4 1.906E-2
1.294E-1
4.383E-1
 2 293
24 hsa-miR-488-3p:TargetScan hsa-miR-488-3p TargetScan 9.591E-4 1.979E-2
1.343E-1
4.776E-1
 2 306
25 hsa-miR-421:TargetScan hsa-miR-421 TargetScan 1.127E-3 1.979E-2
1.343E-1
5.612E-1
 2 332
26 hsa-miR-1537:mirSVR highEffct hsa-miR-1537:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.223E-3 1.979E-2
1.343E-1
6.089E-1
 2 346
27 hsa-miR-18a-3p:Functional MTI Functional MTI miRTarbase 1.251E-3 1.979E-2
1.343E-1
6.228E-1
 2 350
28 hsa-miR-421:PITA hsa-miR-421:PITA TOP PITA 1.286E-3 1.979E-2
1.343E-1
6.405E-1
 2 355
29 hsa-miR-373-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.403E-3 1.979E-2
1.343E-1
6.987E-1
 2 371
30 hsa-miR-371b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.410E-3 1.979E-2
1.343E-1
7.024E-1
 2 372
31 hsa-miR-616-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.433E-3 1.979E-2
1.343E-1
7.136E-1
 2 375
32 hsa-miR-378a-5p:Functional MTI Functional MTI miRTarbase 1.517E-3 1.979E-2
1.343E-1
7.555E-1
 2 386
33 hsa-miR-222-3p:Functional MTI Functional MTI miRTarbase 1.580E-3 1.979E-2
1.343E-1
7.866E-1
 2 394
34 hsa-miR-621:mirSVR highEffct hsa-miR-621:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.627E-3 1.979E-2
1.343E-1
8.104E-1
 2 400
35 hsa-miR-520g-3p:Functional MTI Functional MTI miRTarbase 1.660E-3 1.979E-2
1.343E-1
8.264E-1
 2 404
36 hsa-miR-520h:Functional MTI Functional MTI miRTarbase 1.684E-3 1.979E-2
1.343E-1
8.386E-1
 2 407
37 hsa-miR-30b-5p:Functional MTI Functional MTI miRTarbase 1.758E-3 1.979E-2
1.343E-1
8.755E-1
 2 416
38 hsa-miR-888:PITA hsa-miR-888:PITA TOP PITA 1.791E-3 1.979E-2
1.343E-1
8.921E-1
 2 420
39 hsa-miR-6838-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.885E-3 1.979E-2
1.343E-1
9.386E-1
 2 431
40 CAGTATT,MIR-200C:MSigDB CAGTATT,MIR-200C:MSigDB MSigDB 1.911E-3 1.979E-2
1.343E-1
9.515E-1
 2 434
41 CAGTATT,MIR-429:MSigDB CAGTATT,MIR-429:MSigDB MSigDB 1.911E-3 1.979E-2
1.343E-1
9.515E-1
 2 434
42 CAGTATT,MIR-200B:MSigDB CAGTATT,MIR-200B:MSigDB MSigDB 1.911E-3 1.979E-2
1.343E-1
9.515E-1
 2 434
43 hsa-miR-302e:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.034E-3 1.979E-2
1.343E-1
1.000E0
 2 448
44 hsa-miR-520d-3p:Functional MTI Functional MTI miRTarbase 2.043E-3 1.979E-2
1.343E-1
1.000E0
 2 449
45 hsa-miR-520e:Functional MTI Functional MTI miRTarbase 2.079E-3 1.979E-2
1.343E-1
1.000E0
 2 453
46 hsa-miR-520b:Functional MTI Functional MTI miRTarbase 2.097E-3 1.979E-2
1.343E-1
1.000E0
 2 455
47 hsa-miR-520a-3p:Functional MTI Functional MTI miRTarbase 2.097E-3 1.979E-2
1.343E-1
1.000E0
 2 455
48 hsa-miR-520c-3p:Functional MTI Functional MTI miRTarbase 2.097E-3 1.979E-2
1.343E-1
1.000E0
 2 455
49 hsa-miR-6867-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.133E-3 1.979E-2
1.343E-1
1.000E0
 2 459
50 hsa-miR-302b-3p:Functional MTI Functional MTI miRTarbase 2.142E-3 1.979E-2
1.343E-1
1.000E0
 2 460
Show 45 more annotations

17: Drug [Display Chart] 11 input genes in category / 937 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000069640 L-leucinamide Stitch 3.161E-16 2.962E-13 2.198E-12 2.962E-13 7 64
2 CID000213546 poly(I-C Stitch 1.355E-15 6.346E-13 4.709E-12 1.269E-12 8 171
3 CID000004973 heme b Stitch 1.944E-14 6.070E-12 4.504E-11 1.821E-11 9 444
4 CID000482121 5'-A-G-3 Stitch 2.035E-12 4.768E-10 3.538E-9 1.907E-9 4 8
5 CID000522683 iodine fluoride Stitch 3.962E-11 7.425E-9 5.510E-8 3.713E-8 4 15
6 CID000448381 2hqu Stitch 6.645E-10 1.038E-7 7.701E-7 6.227E-7 6 247
7 CID000001024 pyrroloquinoline quinone Stitch 2.197E-8 2.940E-6 2.182E-5 2.058E-5 4 67
8 CID000001652 3-deazacytidine Stitch 2.513E-8 2.943E-6 2.184E-5 2.355E-5 5 206
9 CID000409844 5H-purin-2-amine Stitch 1.207E-7 1.168E-5 8.670E-5 1.131E-4 4 102
10 CID000447956 2c5o Stitch 1.247E-7 1.168E-5 8.670E-5 1.168E-4 5 284
11 CID000032744 polyinosinic-polycytidylic acid Stitch 1.407E-7 1.199E-5 8.896E-5 1.319E-4 5 291
12 CID011979623 ridostin Stitch 2.027E-7 1.454E-5 1.079E-4 1.900E-4 4 116
13 ctd:C119546 1-palmitoyl-2-(5-oxovaleroyl)phosphatidylcholine CTD 2.109E-7 1.454E-5 1.079E-4 1.976E-4 2 2
14 CID000656983 AC1LCVTP Stitch 2.172E-7 1.454E-5 1.079E-4 2.035E-4 4 118
15 CID000003447 gabexate mesilate Stitch 2.483E-7 1.551E-5 1.151E-4 2.327E-4 4 122
16 CID000213100 S 30 Stitch 3.350E-7 1.962E-5 1.456E-4 3.139E-4 3 30
17 ctd:C512471 chromium (D-Phenylalanine)3 CTD 1.264E-6 6.582E-5 4.884E-4 1.185E-3 2 4
18 ctd:C558809 SR1001 CTD 1.264E-6 6.582E-5 4.884E-4 1.185E-3 2 4
19 CID005288092 peptidomimetic inhibitor Stitch 1.494E-6 7.365E-5 5.465E-4 1.399E-3 4 191
20 CID006490494 PKR inhibitor Stitch 1.813E-6 8.493E-5 6.302E-4 1.699E-3 3 52
21 CID000005033 radicicol Stitch 1.904E-6 8.494E-5 6.303E-4 1.784E-3 4 203
22 ctd:C109992 bis(isopropyl methyl)phosphonate CTD 2.107E-6 8.973E-5 6.659E-4 1.974E-3 2 5
23 CID006386496 AC1O4DJ6 Stitch 4.094E-6 1.668E-4 1.237E-3 3.836E-3 3 68
24 CID005486857 GTPox Stitch 4.422E-6 1.726E-4 1.281E-3 4.144E-3 2 7
25 CID000000298 tifomycin Stitch 5.321E-6 1.973E-4 1.464E-3 4.985E-3 4 263
26 CID000100038 B Hm Stitch 5.895E-6 1.973E-4 1.464E-3 5.523E-3 2 8
27 CID000198267 V-V2 Stitch 5.895E-6 1.973E-4 1.464E-3 5.523E-3 2 8
28 CID000098468 1BnTIQ Stitch 5.895E-6 1.973E-4 1.464E-3 5.523E-3 2 8
29 CID000004778 phenylarsine oxide Stitch 6.439E-6 2.081E-4 1.544E-3 6.034E-3 4 276
30 CID000452638 CP-77 Stitch 7.577E-6 2.290E-4 1.699E-3 7.099E-3 2 9
31 ctd:C041747 nitazoxanide CTD 7.577E-6 2.290E-4 1.699E-3 7.099E-3 2 9
32 CID000189081 2-AP Stitch 8.032E-6 2.352E-4 1.745E-3 7.526E-3 3 85
33 ctd:D008911 Minocycline CTD 8.916E-6 2.432E-4 1.805E-3 8.355E-3 3 88
34 CID000023205 helenalin Stitch 9.225E-6 2.432E-4 1.805E-3 8.644E-3 3 89
35 CID000004888 pranoprofen Stitch 9.468E-6 2.432E-4 1.805E-3 8.872E-3 2 10
36 CID000169121 GuoPP(CH2)P Stitch 9.468E-6 2.432E-4 1.805E-3 8.872E-3 2 10
37 CID004632235 AC1NDVEB Stitch 9.863E-6 2.432E-4 1.805E-3 9.242E-3 3 91
38 CID000002259 aurintricarboxylic acid Stitch 9.863E-6 2.432E-4 1.805E-3 9.242E-3 3 91
39 CID000065065 N-acetyl-L-aspartate Stitch 1.516E-5 3.643E-4 2.703E-3 1.421E-2 3 105
40 CID000000544 arsenite Stitch 1.588E-5 3.720E-4 2.760E-3 1.488E-2 4 347
41 CID000018609 Asp51 Stitch 1.640E-5 3.748E-4 2.781E-3 1.537E-2 2 13
42 ctd:C099158 acetyl-aspartyl-glutamyl-valyl-aspartal CTD 1.913E-5 4.168E-4 3.093E-3 1.792E-2 2 14
43 CID000061217 2,3-dimercaptopropane Stitch 1.913E-5 4.168E-4 3.093E-3 1.792E-2 2 14
44 CID000003460 geldanamicin Stitch 2.109E-5 4.491E-4 3.333E-3 1.976E-2 4 373
45 CID000004004 malathion Stitch 2.207E-5 4.595E-4 3.410E-3 2.068E-2 3 119
46 CID000004288 F-6b Stitch 2.521E-5 4.921E-4 3.652E-3 2.362E-2 2 16
47 ctd:D003974 Diatrizoate Meglumine CTD 2.521E-5 4.921E-4 3.652E-3 2.362E-2 2 16
48 ctd:C561619 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea CTD 2.521E-5 4.921E-4 3.652E-3 2.362E-2 2 16
49 CID000020992 1,6-bismaleimidohexane Stitch 2.856E-5 5.353E-4 3.972E-3 2.676E-2 2 17
50 ctd:C559087 SR 1078 CTD 2.856E-5 5.353E-4 3.972E-3 2.676E-2 2 17
Show 45 more annotations

18: Disease [Display Chart] 11 input genes in category / 228 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1858991 Childhood Ataxia with Central Nervous System Hypomyelinization DisGeNET Curated 2.463E-15 5.615E-13 3.374E-12 5.615E-13 6 24
2 C0270612 Leukoencephalopathies DisGeNET Curated 2.823E-12 3.053E-10 1.834E-9 6.436E-10 6 72
3 C1847967 OVARIOLEUKODYSTROPHY DisGeNET Curated 4.017E-12 3.053E-10 1.834E-9 9.159E-10 4 7
4 C2960129 Vanishing white matter disease DisGeNET BeFree 1.445E-11 8.237E-10 4.950E-9 3.295E-9 4 9
5 C0432217 Wolcott-Rallison syndrome DisGeNET Curated 2.408E-11 1.098E-9 6.597E-9 5.490E-9 4 10
6 C4025319 Cessation of head growth DisGeNET Curated 2.325E-9 5.890E-8 3.539E-7 5.301E-7 3 5
7 OMIN:603896 LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTER; VWM OMIM 2.325E-9 5.890E-8 3.539E-7 5.301E-7 3 5
8 cv:C1858991 Leukoencephalopathy with vanishing white matter Clinical Variations 2.325E-9 5.890E-8 3.539E-7 5.301E-7 3 5
9 C1858995 Decreased serum progesterone DisGeNET Curated 2.325E-9 5.890E-8 3.539E-7 5.301E-7 3 5
10 C1859014 Primary gonadal insufficiency DisGeNET Curated 1.950E-8 4.446E-7 2.672E-6 4.446E-6 3 9
11 C2677328 Brain hypomyelination DisGeNET Curated 3.828E-8 7.934E-7 4.768E-6 8.728E-6 3 11
12 C0240735 Personality change DisGeNET Curated 4.673E-7 8.879E-6 5.335E-5 1.065E-4 3 24
13 C0231686 Gait, Unsteady DisGeNET Curated 8.421E-7 1.477E-5 8.874E-5 1.920E-4 3 29
14 C0232940 Secondary physiologic amenorrhea DisGeNET Curated 9.353E-7 1.523E-5 9.153E-5 2.132E-4 3 30
15 C0011253 Delusions DisGeNET Curated 1.035E-6 1.573E-5 9.454E-5 2.360E-4 3 31
16 C0747102 Ovarian failure DisGeNET BeFree 2.268E-6 3.231E-5 1.942E-4 5.170E-4 3 40
17 C0338474 Central nervous system demyelination DisGeNET Curated 2.446E-6 3.280E-5 1.971E-4 5.576E-4 3 41
18 C0542476 Forgetful DisGeNET Curated 3.712E-6 4.702E-5 2.825E-4 8.463E-4 3 47
19 C0027765 nervous system disorder DisGeNET Curated 4.803E-6 5.764E-5 3.463E-4 1.095E-3 5 423
20 C2931689 Dystrophia myotonica 2 DisGeNET Curated 7.796E-6 8.887E-5 5.340E-4 1.777E-3 3 60
21 C0233794 Memory impairment DisGeNET Curated 1.126E-5 1.222E-4 7.344E-4 2.567E-3 4 226
22 C0751295 Memory Loss DisGeNET Curated 1.656E-5 1.716E-4 1.031E-3 3.776E-3 3 77
23 C0085633 Mood swings DisGeNET Curated 2.075E-5 2.044E-4 1.228E-3 4.732E-3 3 83
24 C0023380 Lethargy DisGeNET Curated 2.152E-5 2.044E-4 1.228E-3 4.905E-3 3 84
25 C0023520 Leukodystrophy DisGeNET Curated 2.309E-5 2.106E-4 1.265E-3 5.265E-3 3 86
26 C1850493 Psychomotor regression, progressive DisGeNET Curated 3.851E-5 2.744E-4 1.649E-3 8.781E-3 3 102
27 C1855019 Psychomotor regression DisGeNET Curated 3.851E-5 2.744E-4 1.649E-3 8.781E-3 3 102
28 C1857121 Neurodevelopmental regression DisGeNET Curated 3.851E-5 2.744E-4 1.649E-3 8.781E-3 3 102
29 C1855996 Psychomotor regression beginning in infancy DisGeNET Curated 3.851E-5 2.744E-4 1.649E-3 8.781E-3 3 102
30 C1855009 Psychomotor regression in infants DisGeNET Curated 3.851E-5 2.744E-4 1.649E-3 8.781E-3 3 102
31 C1836550 Loss of developmental milestones DisGeNET Curated 3.851E-5 2.744E-4 1.649E-3 8.781E-3 3 102
32 C1859678 Mental deterioration in childhood DisGeNET Curated 3.851E-5 2.744E-4 1.649E-3 8.781E-3 3 102
33 C1836830 Developmental regression DisGeNET Curated 4.697E-5 3.245E-4 1.950E-3 1.071E-2 3 109
34 C0038220 Status Epilepticus DisGeNET Curated 6.573E-5 4.408E-4 2.649E-3 1.499E-2 3 122
35 C0023827 liposarcoma DisGeNET Curated 7.941E-5 5.173E-4 3.108E-3 1.811E-2 3 130
36 C0025322 Premature Menopause DisGeNET Curated 1.011E-4 6.403E-4 3.847E-3 2.305E-2 3 141
37 C4280664 Big calvaria DisGeNET Curated 1.144E-4 6.521E-4 3.918E-3 2.608E-2 3 147
38 C4255213 Increased size of skull DisGeNET Curated 1.144E-4 6.521E-4 3.918E-3 2.608E-2 3 147
39 C4083076 Increased head circumference DisGeNET Curated 1.144E-4 6.521E-4 3.918E-3 2.608E-2 3 147
40 C4280663 Increased size of cranium DisGeNET Curated 1.144E-4 6.521E-4 3.918E-3 2.608E-2 3 147
41 C0008073 Developmental Disabilities DisGeNET Curated 1.640E-4 9.119E-4 5.479E-3 3.739E-2 3 166
42 C0085584 Encephalopathies DisGeNET Curated 2.481E-4 1.347E-3 8.091E-3
5.656E-2
 3 191
43 C0013362 Dysarthria DisGeNET Curated 2.677E-4 1.419E-3 8.528E-3
6.103E-2
 3 196
44 C0004134 Ataxia DisGeNET Curated 2.883E-4 1.494E-3 8.975E-3
6.572E-2
 3 201
45 C0006111 Brain Diseases DisGeNET Curated 5.335E-4 2.681E-3 1.611E-2
1.216E-1
 3 248
46 C0029124 Optic Atrophy DisGeNET Curated 5.462E-4 2.681E-3 1.611E-2
1.245E-1
 3 250
47 C0026838 Muscle Spasticity DisGeNET Curated 5.526E-4 2.681E-3 1.611E-2
1.260E-1
 3 251
48 C4023991 Ivory epiphyses of the toes DisGeNET Curated 6.788E-4 2.976E-3 1.788E-2
1.548E-1
 1 1
49 OMIN:226980 EPIPHYSEAL DYSPLASIA, MULTIPLE, WITH EARLY-ONSET DIABETES MELLITUS OMIM 6.788E-4 2.976E-3 1.788E-2
1.548E-1
 1 1
50 C4280415 Irregular ankle bone maturation DisGeNET Curated 6.788E-4 2.976E-3 1.788E-2
1.548E-1
 1 1
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