Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc336_12, positive side

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1: GO: Molecular Function [Display Chart] 12 input genes in category / 44 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070182 DNA polymerase binding 2.945E-5 1.296E-3 5.667E-3 1.296E-3 2 13
2 GO:0048257 3'-flap endonuclease activity 1.286E-3 2.829E-2
1.237E-1
5.657E-2
 1 2
3 GO:0017108 5'-flap endonuclease activity 3.853E-3 4.073E-2
1.781E-1
1.695E-1
 1 6
4 GO:0008821 crossover junction endodeoxyribonuclease activity 5.134E-3 4.073E-2
1.781E-1
2.259E-1
 1 8
5 GO:0048256 flap endonuclease activity 5.134E-3 4.073E-2
1.781E-1
2.259E-1
 1 8
6 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters 6.413E-3 4.073E-2
1.781E-1
2.822E-1
 1 10
7 GO:0061630 ubiquitin protein ligase activity 7.866E-3 4.073E-2
1.781E-1
3.461E-1
 2 212
8 GO:0061659 ubiquitin-like protein ligase activity 8.227E-3 4.073E-2
1.781E-1
3.620E-1
 2 217
9 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 8.330E-3 4.073E-2
1.781E-1
3.665E-1
 1 13
Show 4 more annotations

2: GO: Biological Process [Display Chart] 12 input genes in category / 173 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0036297 interstrand cross-link repair 1.183E-25 2.047E-23 1.174E-22 2.047E-23 10 44
2 GO:2000348 regulation of CD40 signaling pathway 7.979E-6 6.902E-4 3.957E-3 1.380E-3 2 7
3 GO:0023035 CD40 signaling pathway 1.367E-5 7.882E-4 4.519E-3 2.365E-3 2 9
4 GO:0008585 female gonad development 6.363E-5 2.122E-3 1.216E-2 1.101E-2 3 126
5 GO:0046545 development of primary female sexual characteristics 7.144E-5 2.122E-3 1.216E-2 1.236E-2 3 131
6 GO:0045589 regulation of regulatory T cell differentiation 8.730E-5 2.122E-3 1.216E-2 1.510E-2 2 22
7 GO:0046660 female sex differentiation 9.860E-5 2.122E-3 1.216E-2 1.706E-2 3 146
8 GO:0097150 neuronal stem cell population maintenance 1.042E-4 2.122E-3 1.216E-2 1.803E-2 2 24
9 GO:0045066 regulatory T cell differentiation 1.133E-4 2.122E-3 1.216E-2 1.959E-2 2 25
10 GO:0000732 strand displacement 1.226E-4 2.122E-3 1.216E-2 2.122E-2 2 26
11 GO:0006302 double-strand break repair 2.355E-4 3.704E-3 2.124E-2 4.074E-2 3 196
12 GO:0048854 brain morphogenesis 3.547E-4 5.114E-3 2.932E-2
6.136E-2
 2 44
13 GO:0000075 cell cycle checkpoint 3.962E-4 5.273E-3 3.023E-2
6.855E-2
 3 234
14 GO:0008406 gonad development 4.864E-4 5.943E-3 3.407E-2
8.415E-2
 3 251
15 GO:0045137 development of primary sexual characteristics 5.153E-4 5.943E-3 3.407E-2
8.914E-2
 3 256
16 GO:0006310 DNA recombination 5.825E-4 6.298E-3 3.611E-2
1.008E-1
 3 267
17 GO:0007548 sex differentiation 8.906E-4 9.063E-3
5.196E-2
1.541E-1
 3 309
18 GO:0001541 ovarian follicle development 1.002E-3 9.369E-3
5.372E-2
1.733E-1
 2 74
19 GO:0000731 DNA synthesis involved in DNA repair 1.029E-3 9.369E-3
5.372E-2
1.780E-1
 2 75
20 GO:0000724 double-strand break repair via homologous recombination 1.576E-3 1.326E-2
7.603E-2
2.727E-1
 2 93
21 GO:0000725 recombinational repair 1.610E-3 1.326E-2
7.603E-2
2.785E-1
 2 94
22 GO:0016236 macroautophagy 2.168E-3 1.651E-2
9.467E-2
3.750E-1
 3 421
23 GO:0022602 ovulation cycle process 2.195E-3 1.651E-2
9.467E-2
3.798E-1
 2 110
24 GO:0006289 nucleotide-excision repair 2.563E-3 1.712E-2
9.818E-2
4.434E-1
 2 119
25 GO:1904431 positive regulation of t-circle formation 2.575E-3 1.712E-2
9.818E-2
4.455E-1
 1 4
26 GO:0072429 response to intra-S DNA damage checkpoint signaling 2.575E-3 1.712E-2
9.818E-2
4.455E-1
 1 4
27 GO:0048608 reproductive structure development 3.203E-3 1.712E-2
9.818E-2
5.541E-1
 3 483
28 GO:0045580 regulation of T cell differentiation 3.235E-3 1.712E-2
9.818E-2
5.597E-1
 2 134
29 GO:0061458 reproductive system development 3.279E-3 1.712E-2
9.818E-2
5.672E-1
 3 487
30 GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization 3.379E-3 1.712E-2
9.818E-2
5.845E-1
 2 137
31 GO:0098780 response to mitochondrial depolarisation 3.379E-3 1.712E-2
9.818E-2
5.845E-1
 2 137
32 GO:0042698 ovulation cycle 3.427E-3 1.712E-2
9.818E-2
5.929E-1
 2 138
33 GO:0000423 mitophagy 3.574E-3 1.712E-2
9.818E-2
6.184E-1
 2 141
34 GO:0031052 chromosome breakage 3.860E-3 1.712E-2
9.818E-2
6.679E-1
 1 6
35 GO:0072396 response to cell cycle checkpoint signaling 3.860E-3 1.712E-2
9.818E-2
6.679E-1
 1 6
36 GO:0031049 programmed DNA elimination 3.860E-3 1.712E-2
9.818E-2
6.679E-1
 1 6
37 GO:0072423 response to DNA damage checkpoint signaling 3.860E-3 1.712E-2
9.818E-2
6.679E-1
 1 6
38 GO:0072402 response to DNA integrity checkpoint signaling 3.860E-3 1.712E-2
9.818E-2
6.679E-1
 1 6
39 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing 3.860E-3 1.712E-2
9.818E-2
6.679E-1
 1 6
40 GO:0000077 DNA damage checkpoint 4.247E-3 1.837E-2
1.053E-1
7.347E-1
 2 154
41 GO:0045002 double-strand break repair via single-strand annealing 4.503E-3 1.855E-2
1.063E-1
7.789E-1
 1 7
42 GO:1904429 regulation of t-circle formation 4.503E-3 1.855E-2
1.063E-1
7.789E-1
 1 7
43 GO:0045619 regulation of lymphocyte differentiation 4.687E-3 1.886E-2
1.081E-1
8.109E-1
 2 162
44 GO:0031570 DNA integrity checkpoint 4.801E-3 1.888E-2
1.082E-1
8.305E-1
 2 164
45 GO:0090656 t-circle formation 5.144E-3 1.978E-2
1.134E-1
8.900E-1
 1 8
46 GO:0019827 stem cell population maintenance 5.387E-3 2.026E-2
1.162E-1
9.319E-1
 2 174
47 GO:0098727 maintenance of cell number 5.569E-3 2.050E-2
1.175E-1
9.634E-1
 2 177
48 GO:1903046 meiotic cell cycle process 6.719E-3 2.422E-2
1.388E-1
1.000E0
 2 195
49 GO:0000422 autophagy of mitochondrion 7.612E-3 2.634E-2
1.510E-1
1.000E0
 2 208
50 GO:0061726 mitochondrion disassembly 7.612E-3 2.634E-2
1.510E-1
1.000E0
 2 208
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 12 input genes in category / 14 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043240 Fanconi anaemia nuclear complex 7.372E-24 1.032E-22 3.356E-22 1.032E-22 8 15
2 GO:0033557 Slx1-Slx4 complex 1.888E-3 8.809E-3 2.864E-2 2.643E-2 1 3
3 GO:0070522 ERCC4-ERCC1 complex 1.888E-3 8.809E-3 2.864E-2 2.643E-2 1 3
4 GO:0048476 Holliday junction resolvase complex 3.144E-3 1.100E-2 3.578E-2 4.402E-2 1 5
5 GO:0000109 nucleotide-excision repair complex 8.781E-3 2.459E-2
7.994E-2
1.229E-1
 1 14

4: Human Phenotype [Display Chart] 12 input genes in category / 441 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0005522 Pyridoxine-responsive sideroblastic anemia 5.173E-31 2.281E-28 1.521E-27 2.281E-28 12 20
2 HP:0010293 Aplasia/Hypoplasia of the uvula 1.207E-30 2.662E-28 1.775E-27 5.323E-28 12 21
3 HP:0010469 Absent testis 2.656E-30 3.904E-28 2.603E-27 1.171E-27 12 22
4 HP:0200005 Abnormal shape of the palpebral fissure 1.111E-29 9.795E-28 6.531E-27 4.897E-27 12 24
5 HP:0007874 Almond-shaped palpebral fissure 1.111E-29 9.795E-28 6.531E-27 4.897E-27 12 24
6 HP:0012848 Small intestinal stenosis 2.136E-29 1.345E-27 8.971E-27 9.418E-27 12 25
7 HP:0100867 Duodenal stenosis 2.136E-29 1.345E-27 8.971E-27 9.418E-27 12 25
8 HP:0001905 Congenital thrombocytopenia 7.139E-29 3.935E-27 2.624E-26 3.148E-26 12 27
9 HP:0100587 Abnormality of the preputium 2.131E-28 9.399E-27 6.267E-26 9.399E-26 12 29
10 HP:0004859 Amegakaryocytic thrombocytopenia 2.131E-28 9.399E-27 6.267E-26 9.399E-26 12 29
11 HP:0011133 Increased sensitivity to ionizing radiation 9.273E-28 3.718E-26 2.479E-25 4.089E-25 12 32
12 HP:0030976 Abnormal factor VIII activity 2.252E-27 7.094E-26 4.730E-25 9.931E-25 12 34
13 HP:0003125 Reduced factor VIII activity 2.252E-27 7.094E-26 4.730E-25 9.931E-25 12 34
14 HP:0003254 Abnormality of DNA repair 2.252E-27 7.094E-26 4.730E-25 9.931E-25 12 34
15 HP:0005510 Transient erythroblastopenia 3.427E-27 1.008E-25 6.717E-25 1.511E-24 12 35
16 HP:0002245 Meckel diverticulum 7.608E-27 2.097E-25 1.398E-24 3.355E-24 12 37
17 HP:0005505 Refractory anemia 1.112E-26 2.884E-25 1.923E-24 4.903E-24 12 38
18 HP:0011018 Abnormality of the cell cycle 2.294E-26 5.621E-25 3.748E-24 1.012E-23 12 40
19 HP:0000813 Bicornuate uterus 4.541E-26 1.054E-24 7.028E-24 2.003E-23 12 42
20 HP:0004810 Congenital hypoplastic anemia 1.181E-25 2.604E-24 1.736E-23 5.209E-23 12 45
21 HP:0100760 Clubbing of toes 1.598E-25 3.356E-24 2.237E-23 7.047E-23 12 46
22 HP:0000297 Facial hypotonia 4.986E-25 8.456E-24 5.638E-23 2.199E-22 12 50
23 HP:0002246 Abnormality of the duodenum 4.986E-25 8.456E-24 5.638E-23 2.199E-22 12 50
24 HP:0009619 Accessory phalanx of the thumb 4.986E-25 8.456E-24 5.638E-23 2.199E-22 12 50
25 HP:0001199 Triphalangeal thumb 4.986E-25 8.456E-24 5.638E-23 2.199E-22 12 50
26 HP:0004820 Acute myelomonocytic leukemia 4.986E-25 8.456E-24 5.638E-23 2.199E-22 12 50
27 HP:0001549 Abnormal ileum morphology 6.520E-25 1.027E-23 6.846E-23 2.875E-22 12 51
28 HP:0003220 Abnormality of chromosome stability 6.520E-25 1.027E-23 6.846E-23 2.875E-22 12 51
29 HP:0007565 Multiple cafe-au-lait spots 2.293E-24 3.487E-23 2.325E-22 1.011E-21 12 56
30 HP:0012324 Myeloid leukemia 2.905E-24 4.132E-23 2.755E-22 1.281E-21 12 57
31 HP:0001924 Sideroblastic anemia 2.905E-24 4.132E-23 2.755E-22 1.281E-21 12 57
32 HP:0005344 Abnormal carotid artery morphology 5.747E-24 7.920E-23 5.280E-22 2.534E-21 12 60
33 HP:0010989 Abnormality of the intrinsic pathway 1.096E-23 1.464E-22 9.764E-22 4.833E-21 12 63
34 HP:0040071 Abnormal morphology of ulna 2.991E-23 3.768E-22 2.512E-21 1.319E-20 12 68
35 HP:0003022 Hypoplasia of the ulna 2.991E-23 3.768E-22 2.512E-21 1.319E-20 12 68
36 HP:0004431 Complement deficiency 3.620E-23 4.315E-22 2.877E-21 1.596E-20 12 69
37 HP:0000072 Hydroureter 3.620E-23 4.315E-22 2.877E-21 1.596E-20 12 69
38 HP:0009778 Short thumb 1.274E-22 1.441E-21 9.605E-21 5.618E-20 12 76
39 HP:0006495 Aplasia/Hypoplasia of the ulna 1.274E-22 1.441E-21 9.605E-21 5.618E-20 12 76
40 HP:0001972 Macrocytic anemia 1.509E-22 1.623E-21 1.082E-20 6.656E-20 12 77
41 HP:0008572 External ear malformation 1.509E-22 1.623E-21 1.082E-20 6.656E-20 12 77
42 HP:0001217 Clubbing 1.784E-22 1.873E-21 1.249E-20 7.866E-20 12 78
43 HP:0002575 Tracheoesophageal fistula 2.103E-22 2.108E-21 1.405E-20 9.275E-20 12 79
44 HP:0002916 Abnormality of chromosome segregation 2.103E-22 2.108E-21 1.405E-20 9.275E-20 12 79
45 HP:0001908 Hypoplastic anemia 3.977E-22 3.898E-21 2.599E-20 1.754E-19 12 83
46 HP:0012745 Short palpebral fissure 4.640E-22 4.449E-21 2.966E-20 2.046E-19 12 84
47 HP:0005528 Bone marrow hypocellularity 6.279E-22 5.769E-21 3.847E-20 2.769E-19 12 86
48 HP:0006501 Aplasia/Hypoplasia of the radius 6.279E-22 5.769E-21 3.847E-20 2.769E-19 12 86
49 HP:0000453 Choanal atresia 8.434E-22 7.591E-21 5.061E-20 3.719E-19 12 88
50 HP:0009821 Forearm undergrowth 9.749E-22 8.598E-21 5.733E-20 4.299E-19 12 89
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 11 input genes in category / 314 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004030 induced chromosome breakage 4.748E-14 1.491E-11 9.434E-11 1.491E-11 6 25
2 MP:0004028 chromosome breakage 1.881E-13 2.953E-11 1.869E-10 5.907E-11 7 72
3 MP:0001131 abnormal ovarian follicle morphology 4.571E-12 4.784E-10 3.028E-9 1.435E-9 8 214
4 MP:0008866 chromosomal instability 7.040E-12 4.980E-10 3.151E-9 2.211E-9 7 119
5 MP:0010094 abnormal chromosome stability 7.930E-12 4.980E-10 3.151E-9 2.490E-9 7 121
6 MP:0001126 abnormal ovary morphology 1.348E-10 7.052E-9 4.463E-8 4.231E-8 8 326
7 MP:0013324 abnormal female reproductive gland morphology 3.112E-10 1.396E-8 8.835E-8 9.772E-8 8 362
8 MP:0001127 small ovary 3.355E-9 1.235E-7 7.815E-7 1.053E-6 6 148
9 MP:0009209 abnormal internal female genitalia morphology 3.690E-9 1.235E-7 7.815E-7 1.159E-6 8 494
10 MP:0002209 decreased germ cell number 3.933E-9 1.235E-7 7.815E-7 1.235E-6 8 498
11 MP:0004853 abnormal ovary size 7.468E-9 2.132E-7 1.349E-6 2.345E-6 6 169
12 MP:0002216 abnormal seminiferous tubule morphology 1.314E-8 3.438E-7 2.176E-6 4.126E-6 7 347
13 MP:0008391 abnormal primordial germ cell morphology 4.995E-8 1.206E-6 7.635E-6 1.568E-5 4 38
14 MP:0002673 abnormal sperm number 5.703E-8 1.279E-6 8.094E-6 1.791E-5 7 429
15 MP:0004901 decreased male germ cell number 7.341E-8 1.492E-6 9.445E-6 2.305E-5 7 445
16 MP:0002687 oligozoospermia 7.605E-8 1.492E-6 9.445E-6 2.388E-5 6 249
17 MP:0008871 abnormal ovarian follicle number 1.517E-7 2.802E-6 1.773E-5 4.764E-5 5 135
18 MP:0001149 testicular hyperplasia 2.121E-7 3.701E-6 2.342E-5 6.661E-5 4 54
19 MP:0008943 increased sensitivity to induced cell death 6.733E-7 1.113E-5 7.042E-5 2.114E-4 5 182
20 MP:0003111 abnormal cell nucleus morphology 9.010E-7 1.415E-5 8.951E-5 2.829E-4 5 193
21 MP:0003702 abnormal chromosome morphology 1.046E-6 1.564E-5 9.898E-5 3.285E-4 4 80
22 MP:0001148 enlarged testis 1.336E-6 1.906E-5 1.206E-4 4.194E-4 4 85
23 MP:0014040 increased cellular sensitivity to DNA damaging agents 2.288E-6 3.124E-5 1.977E-4 7.185E-4 3 26
24 MP:0001130 abnormal ovarian folliculogenesis 3.119E-6 4.081E-5 2.582E-4 9.794E-4 4 105
25 MP:0008942 abnormal induced cell death 3.564E-6 4.477E-5 2.833E-4 1.119E-3 5 255
26 MP:0004029 spontaneous chromosome breakage 4.350E-6 5.253E-5 3.324E-4 1.366E-3 3 32
27 MP:0008392 decreased primordial germ cell number 5.730E-6 6.664E-5 4.217E-4 1.799E-3 3 35
28 MP:0002016 ovary cysts 2.270E-5 2.546E-4 1.611E-3 7.129E-3 3 55
29 MP:0002682 decreased mature ovarian follicle number 3.260E-5 3.529E-4 2.233E-3 1.024E-2 3 62
30 MP:0005158 ovary hypoplasia 3.679E-5 3.726E-4 2.358E-3 1.155E-2 2 9
31 MP:0002776 Sertoli cell hyperplasia 3.679E-5 3.726E-4 2.358E-3 1.155E-2 2 9
32 MP:0009364 abnormal mature ovarian follicle morphology 4.497E-5 4.413E-4 2.793E-3 1.412E-2 3 69
33 MP:0003179 thrombocytopenia 5.819E-5 5.537E-4 3.504E-3 1.827E-2 4 220
34 MP:0002784 abnormal Sertoli cell morphology 6.010E-5 5.550E-4 3.512E-3 1.887E-2 3 76
35 MP:0008390 abnormal primordial germ cell proliferation 7.952E-5 7.134E-4 4.514E-3 2.497E-2 2 13
36 MP:0001154 seminiferous tubule degeneration 1.207E-4 1.053E-3 6.664E-3 3.791E-2 3 96
37 MP:0001923 reduced female fertility 1.466E-4 1.244E-3 7.872E-3 4.602E-2 4 279
38 MP:0008873 increased physiological sensitivity to xenobiotic 1.591E-4 1.315E-3 8.322E-3 4.997E-2 4 285
39 MP:0010288 increased gland tumor incidence 1.725E-4 1.382E-3 8.746E-3
5.416E-2
 4 291
40 MP:0011750 abnormal seminiferous tubule epithelium morphology 1.761E-4 1.382E-3 8.746E-3
5.528E-2
 3 109
41 MP:0011898 abnormal platelet cell number 1.890E-4 1.426E-3 9.027E-3
5.936E-2
 4 298
42 MP:0002679 abnormal corpus luteum morphology 1.908E-4 1.426E-3 9.027E-3
5.991E-2
 3 112
43 MP:0008058 abnormal DNA repair 2.640E-4 1.928E-3 1.220E-2
8.290E-2
 3 125
44 MP:0020363 abnormal germ cell physiology 3.037E-4 2.167E-3 1.372E-2
9.537E-2
 2 25
45 MP:0001935 decreased litter size 3.318E-4 2.316E-3 1.465E-2
1.042E-1
 4 345
46 MP:0001933 abnormal litter size 3.702E-4 2.527E-3 1.599E-2
1.162E-1
 4 355
47 MP:0002590 increased mean corpuscular volume 4.170E-4 2.786E-3 1.763E-2
1.309E-1
 3 146
48 MP:0008280 abnormal male germ cell apoptosis 4.693E-4 3.070E-3 1.943E-2
1.474E-1
 3 152
49 MP:0004720 abnormal platelet morphology 5.721E-4 3.666E-3 2.320E-2
1.796E-1
 4 398
50 MP:0013662 decreased myeloid cell number 6.765E-4 4.248E-3 2.689E-2
2.124E-1
 4 416
Show 45 more annotations

6: Domain [Display Chart] 12 input genes in category / 76 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF11793 FANCL C Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
2 IPR029305 FANCI S1-cap InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
3 PF09765 WD-3 Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
4 IPR029310 FANCI HD1 InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
5 PF16756 PALB2 WD40 Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
6 IPR031729 Fanconi A N InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
7 IPR029312 FANCI HD2 InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
8 PF14631 FancD2 Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
9 IPR029313 FANCI S3 InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
10 PF14674 FANCI S1-cap Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
11 IPR029448 FANCD2 InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
12 IPR025825 FANCF InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
13 IPR019162 FancL WD-rpt cont dom InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
14 IPR029308 FANCI S1 InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
15 IPR026848 Fancl InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
16 IPR021025 Fanconi anaemia gr E prot C InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
17 PD321645 PD321645 ProDom 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
18 IPR026850 FANCL C InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
19 PF14675 FANCI S1 Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
20 IPR033333 FANCB InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
21 IPR031920 PALB2 WD40 InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
22 PF14680 FANCI HD2 Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
23 PF14677 FANCI S3 Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
24 PF02106 Fanconi C Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
25 PF15865 Fanconi A N Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
26 PF03511 Fanconi A Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
27 PF14676 FANCI S2 Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
28 IPR026171 FANCI InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
29 IPR018574 Structure-sp endonuc su Slx4 InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
30 IPR003516 FANCA InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
31 PF14678 FANCI S4 Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
32 IPR029315 FANCI S2 InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
33 PF09494 Slx4 Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
34 IPR000686 Fanconi InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
35 PF14679 FANCI HD1 Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
36 PF11510 FA FANCE Pfam 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
37 IPR029314 FANCI S4 InterPro 6.405E-4 1.316E-3 6.466E-3 4.868E-2 1 1
38 IPR013020 DNA helicase DNA-repair Rad3 InterPro 2.560E-3 4.139E-3 2.034E-2
1.945E-1
 1 4
39 PF13307 Helicase C 2 Pfam 2.560E-3 4.139E-3 2.034E-2
1.945E-1
 1 4
40 SM00491 HELICc2 SMART 2.560E-3 4.139E-3 2.034E-2
1.945E-1
 1 4
41 SM00488 DEXDc2 SMART 2.560E-3 4.139E-3 2.034E-2
1.945E-1
 1 4
42 PS51193 HELICASE ATP BIND 2 PROSITE 2.560E-3 4.139E-3 2.034E-2
1.945E-1
 1 4
43 IPR014013 Helic SF1/SF2 ATP-bd DinG/Rad3 InterPro 2.560E-3 4.139E-3 2.034E-2
1.945E-1
 1 4
44 IPR006555 ATP-dep Helicase C InterPro 2.560E-3 4.139E-3 2.034E-2
1.945E-1
 1 4
45 PF06733 DEAD 2 Pfam 2.560E-3 4.139E-3 2.034E-2
1.945E-1
 1 4
46 IPR010614 DEAD 2 InterPro 2.560E-3 4.139E-3 2.034E-2
1.945E-1
 1 4
47 IPR006554 Helicase-like DEXD c2 InterPro 2.560E-3 4.139E-3 2.034E-2
1.945E-1
 1 4
48 IPR009075 AcylCo DH/oxidase C InterPro 1.020E-2 1.616E-2
7.939E-2
7.754E-1
 1 16
49 IPR002464 DNA/RNA helicase DEAH CS InterPro 2.220E-2 3.443E-2
1.692E-1
1.000E0
 1 35
50 PS00690 DEAH ATP HELICASE PROSITE 2.408E-2 3.660E-2
1.799E-1
1.000E0
 1 38
Show 45 more annotations

7: Pathway [Display Chart] 12 input genes in category / 26 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 377262 Fanconi anemia pathway BioSystems: KEGG 1.523E-29 3.961E-28 1.527E-27 3.961E-28 12 55
2 1309121 Fanconi Anemia Pathway BioSystems: REACTOME 2.267E-24 2.947E-23 1.136E-22 5.895E-23 10 40
3 1270350 DNA Repair BioSystems: REACTOME 6.528E-20 5.658E-19 2.181E-18 1.697E-18 12 319
4 137959 BARD1 signaling events BioSystems: Pathway Interaction Database 1.336E-16 8.682E-16 3.346E-15 3.473E-15 7 29
5 M9703 Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility MSigDB C2 BIOCARTA (v6.0) 6.422E-12 3.340E-11 1.287E-10 1.670E-10 5 21
6 1309106 Resolution of D-loop Structures through Holliday Junction Intermediates BioSystems: REACTOME 4.401E-6 1.782E-5 6.870E-5 1.144E-4 3 35
7 1309105 Resolution of D-Loop Structures BioSystems: REACTOME 4.798E-6 1.782E-5 6.870E-5 1.248E-4 3 36
8 1309102 HDR through Homologous Recombination (HRR) BioSystems: REACTOME 3.459E-5 1.124E-4 4.332E-4 8.992E-4 3 69
9 1383075 TP53 Regulates Transcription of DNA Repair Genes BioSystems: REACTOME 3.930E-5 1.135E-4 4.377E-4 1.022E-3 3 72
10 1309100 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) BioSystems: REACTOME 2.498E-4 6.391E-4 2.463E-3 6.495E-3 3 134
11 1309099 Homology Directed Repair BioSystems: REACTOME 2.843E-4 6.391E-4 2.463E-3 7.391E-3 3 140
12 1309107 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) BioSystems: REACTOME 2.950E-4 6.391E-4 2.463E-3 7.669E-3 2 27
13 1269654 Transcriptional Regulation by TP53 BioSystems: REACTOME 3.276E-4 6.551E-4 2.525E-3 8.517E-3 4 374
14 1309095 DNA Double-Strand Break Repair BioSystems: REACTOME 4.940E-4 9.174E-4 3.536E-3 1.284E-2 3 169
15 83046 Homologous recombination BioSystems: KEGG 6.839E-4 1.185E-3 4.569E-3 1.778E-2 2 41
16 1309103 Homologous DNA Pairing and Strand Exchange BioSystems: REACTOME 7.524E-4 1.223E-3 4.712E-3 1.956E-2 2 43
17 1270230 Cytosolic iron-sulfur cluster assembly BioSystems: REACTOME 1.246E-2 1.906E-2
7.347E-2
3.241E-1
 1 13
Show 12 more annotations

8: Pubmed [Display Chart] 12 input genes in category / 1022 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20301575 Fanconi Anemia Pubmed 1.464E-41 1.496E-38 1.123E-37 1.496E-38 12 21
2 20301753 Esophageal Atresia/Tracheoesophageal Fistula Overview Pubmed 3.221E-41 1.646E-38 1.236E-37 3.292E-38 12 22
3 27986371 Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway. Pubmed 3.303E-31 1.125E-28 8.448E-28 3.376E-28 9 13
4 19536649 The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features. Pubmed 2.312E-30 5.907E-28 4.434E-27 2.363E-27 9 15
5 15502827 X-linked inheritance of Fanconi anemia complementation group B. Pubmed 4.411E-30 9.017E-28 6.769E-27 4.508E-27 8 8
6 16116422 A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Pubmed 2.183E-27 3.718E-25 2.791E-24 2.231E-24 8 12
7 19690177 Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. Pubmed 9.302E-27 1.358E-24 1.020E-23 9.506E-24 9 31
8 22705371 A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. Pubmed 5.551E-25 7.091E-23 5.323E-22 5.673E-22 8 20
9 17396147 FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway. Pubmed 1.213E-24 1.239E-22 9.303E-22 1.239E-21 7 9
10 23303816 Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1. Pubmed 1.213E-24 1.239E-22 9.303E-22 1.239E-21 7 9
11 12973351 A novel ubiquitin ligase is deficient in Fanconi anemia. Pubmed 2.667E-23 2.478E-21 1.860E-20 2.725E-20 7 12
12 12649160 Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems. Pubmed 2.144E-22 1.581E-20 1.187E-19 2.191E-19 6 6
13 12093742 FANCE: the link between Fanconi anaemia complex assembly and activity. Pubmed 2.144E-22 1.581E-20 1.187E-19 2.191E-19 6 6
14 17289582 Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Pubmed 2.166E-22 1.581E-20 1.187E-19 2.214E-19 7 15
15 20347428 A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Pubmed 3.850E-22 2.623E-20 1.969E-19 3.935E-19 7 16
16 22343915 FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway. Pubmed 1.071E-21 6.840E-20 5.135E-19 1.094E-18 7 18
17 24451376 The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway. Pubmed 1.501E-21 8.521E-20 6.397E-19 1.534E-18 6 7
18 16720839 Evidence for subcomplexes in the Fanconi anemia pathway. Pubmed 1.501E-21 8.521E-20 6.397E-19 1.534E-18 6 7
19 18550849 HES1 is a novel interactor of the Fanconi anemia core complex. Pubmed 4.500E-20 2.421E-18 1.817E-17 4.599E-17 6 10
20 12724401 A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Pubmed 1.980E-19 1.012E-17 7.594E-17 2.023E-16 6 12
21 16474167 The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly. Pubmed 1.170E-18 4.598E-17 3.452E-16 1.196E-15 5 5
22 9382107 Evidence for at least eight Fanconi anemia genes. Pubmed 1.170E-18 4.598E-17 3.452E-16 1.196E-15 5 5
23 17082180 Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex. Pubmed 1.170E-18 4.598E-17 3.452E-16 1.196E-15 5 5
24 11157805 Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway. Pubmed 1.170E-18 4.598E-17 3.452E-16 1.196E-15 5 5
25 15262960 The Fanconi anemia gene product FANCF is a flexible adaptor protein. Pubmed 1.170E-18 4.598E-17 3.452E-16 1.196E-15 5 5
26 12239156 The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC. Pubmed 1.170E-18 4.598E-17 3.452E-16 1.196E-15 5 5
27 15082718 The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments. Pubmed 2.456E-17 9.296E-16 6.978E-15 2.510E-14 5 7
28 18950845 Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. Pubmed 2.300E-16 8.339E-15 6.260E-14 2.350E-13 7 89
29 19714462 Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. Pubmed 2.366E-16 8.339E-15 6.260E-14 2.418E-13 6 33
30 16889989 alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus. Pubmed 2.873E-16 9.711E-15 7.290E-14 2.936E-13 6 34
31 19321451 The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling. Pubmed 2.946E-16 9.711E-15 7.290E-14 3.010E-13 5 10
32 20347429 MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Pubmed 2.339E-15 7.469E-14 5.607E-13 2.390E-12 5 14
33 27760317 Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications. Pubmed 5.101E-15 1.542E-13 1.158E-12 5.213E-12 5 16
34 16127171 FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway. Pubmed 5.584E-15 1.542E-13 1.158E-12 5.707E-12 4 4
35 11063725 The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. Pubmed 5.584E-15 1.542E-13 1.158E-12 5.707E-12 4 4
36 11750104 Function of the Fanconi anemia pathway in Fanconi anemia complementation group F and D1 cells. Pubmed 5.584E-15 1.542E-13 1.158E-12 5.707E-12 4 4
37 12444097 Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants. Pubmed 5.584E-15 1.542E-13 1.158E-12 5.707E-12 4 4
38 20496165 Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Pubmed 2.327E-14 6.225E-13 4.673E-12 2.379E-11 6 68
39 19064572 Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. Pubmed 2.375E-14 6.225E-13 4.673E-12 2.428E-11 7 170
40 22653977 FANCL ubiquitinates β-catenin and enhances its nuclear function. Pubmed 2.792E-14 7.132E-13 5.354E-12 2.853E-11 4 5
41 26277624 Analysis of a FANCE Splice Isoform in Regard to DNA Repair. Pubmed 8.373E-14 1.945E-12 1.460E-11 8.557E-11 4 6
42 18212739 FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. Pubmed 8.373E-14 1.945E-12 1.460E-11 8.557E-11 4 6
43 20450923 Several tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance. Pubmed 8.373E-14 1.945E-12 1.460E-11 8.557E-11 4 6
44 20518497 Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair. Pubmed 8.373E-14 1.945E-12 1.460E-11 8.557E-11 4 6
45 22266823 Regulation of Rev1 by the Fanconi anemia core complex. Pubmed 1.953E-13 4.248E-12 3.189E-11 1.996E-10 4 7
46 24469828 The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression. Pubmed 1.953E-13 4.248E-12 3.189E-11 1.996E-10 4 7
47 24910428 Modularized functions of the Fanconi anemia core complex. Pubmed 1.953E-13 4.248E-12 3.189E-11 1.996E-10 4 7
48 19995904 DNA polymerase POLN participates in cross-link repair and homologous recombination. Pubmed 3.906E-13 8.317E-12 6.244E-11 3.992E-10 4 8
49 26269593 Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ν (POLN). Pubmed 7.030E-13 1.466E-11 1.101E-10 7.185E-10 4 9
50 26625197 Forkhead transcription factor FoxF1 interacts with Fanconi anemia protein complexes to promote DNA damage response. Pubmed 1.841E-12 3.762E-11 2.824E-10 1.881E-9 4 11
Show 45 more annotations

9: Interaction [Display Chart] 12 input genes in category / 1871 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:FAAP20 FAAP20 interactions 4.206E-22 7.869E-19 6.383E-18 7.869E-19 8 21
2 int:FANCM FANCM interactions 1.967E-19 1.515E-16 1.229E-15 3.680E-16 8 41
3 int:FANCL FANCL interactions 2.429E-19 1.515E-16 1.229E-15 4.545E-16 8 42
4 int:FANCB FANCB interactions 5.667E-19 2.651E-16 2.150E-15 1.060E-15 7 20
5 int:FANCF FANCF interactions 1.246E-18 4.663E-16 3.783E-15 2.332E-15 7 22
6 int:FANCC FANCC interactions 1.546E-18 4.820E-16 3.910E-15 2.892E-15 8 52
7 int:FANCE FANCE interactions 6.481E-18 1.516E-15 1.229E-14 1.213E-14 7 27
8 int:CENPS CENPS interactions 6.481E-18 1.516E-15 1.229E-14 1.213E-14 7 27
9 int:FANCG FANCG interactions 3.449E-17 7.171E-15 5.817E-14 6.454E-14 8 75
10 int:FAAP100 FAAP100 interactions 1.962E-16 3.670E-14 2.977E-13 3.670E-13 7 42
11 int:FANCA FANCA interactions 1.116E-15 1.899E-13 1.540E-12 2.089E-12 8 114
12 int:CENPX CENPX interactions 2.173E-15 3.388E-13 2.748E-12 4.065E-12 6 23
13 int:POLN POLN interactions 1.276E-14 1.836E-12 1.489E-11 2.386E-11 6 30
14 int:HES1 HES1 interactions 5.509E-13 7.363E-11 5.973E-10 1.031E-9 6 54
15 int:SPTA1 SPTA1 interactions 1.308E-12 1.632E-10 1.324E-9 2.448E-9 6 62
16 int:CTBP1 CTBP1 interactions 1.435E-11 1.678E-9 1.361E-8 2.685E-8 7 197
17 int:FAAP24 FAAP24 interactions 4.664E-10 5.134E-8 4.164E-7 8.727E-7 4 19
18 int:FOXF1 FOXF1 interactions 1.795E-9 1.865E-7 1.513E-6 3.358E-6 4 26
19 int:BRCA2 BRCA2 interactions 5.622E-9 5.536E-7 4.490E-6 1.052E-5 5 107
20 int:ERCC4 ERCC4 interactions 7.896E-9 7.387E-7 5.992E-6 1.477E-5 4 37
21 int:CAPN1 CAPN1 interactions 1.685E-8 1.501E-6 1.218E-5 3.153E-5 5 133
22 int:TOP3A TOP3A interactions 5.034E-8 4.281E-6 3.473E-5 9.419E-5 4 58
23 int:SPTAN1 SPTAN1 interactions 2.186E-7 1.778E-5 1.442E-4 4.090E-4 5 222
24 int:PCNA PCNA interactions 1.335E-6 1.041E-4 8.442E-4 2.498E-3 5 320
25 int:BLM BLM interactions 1.766E-6 1.321E-4 1.072E-3 3.303E-3 4 140
26 int:RAD51 RAD51 interactions 1.922E-6 1.383E-4 1.122E-3 3.595E-3 4 143
27 int:UBE2T UBE2T interactions 2.318E-6 1.595E-4 1.294E-3 4.337E-3 3 40
28 int:MSH2 MSH2 interactions 2.387E-6 1.595E-4 1.294E-3 4.467E-3 4 151
29 int:FAN1 FAN1 interactions 3.794E-6 2.448E-4 1.986E-3 7.099E-3 3 47
30 int:MMS19 MMS19 interactions 7.289E-6 4.546E-4 3.688E-3 1.364E-2 4 200
31 int:RPA1 RPA1 interactions 1.150E-5 6.940E-4 5.629E-3 2.151E-2 5 497
32 int:SAMD3 SAMD3 interactions 1.512E-5 8.771E-4 7.115E-3 2.830E-2 2 9
33 int:NOTCH1 NOTCH1 interactions 1.547E-5 8.771E-4 7.115E-3 2.894E-2 4 242
34 int:GGN GGN interactions 1.890E-5 9.867E-4 8.004E-3 3.536E-2 2 10
35 int:PRDX3 PRDX3 interactions 1.898E-5 9.867E-4 8.004E-3 3.552E-2 3 80
36 int:FANCI FANCI interactions 1.898E-5 9.867E-4 8.004E-3 3.552E-2 3 80
37 int:HELQ HELQ interactions 2.770E-5 1.401E-3 1.136E-2
5.182E-2
 2 12
38 int:KRT1 KRT1 interactions 3.385E-5 1.667E-3 1.352E-2
6.333E-2
 3 97
39 int:NBN NBN interactions 3.490E-5 1.674E-3 1.358E-2
6.531E-2
 3 98
40 int:PIAS4 PIAS4 interactions 4.414E-5 2.065E-3 1.675E-2
8.258E-2
 3 106
41 int:DCLRE1B DCLRE1B interactions 5.028E-5 2.294E-3 1.861E-2
9.407E-2
 2 16
42 int:IKZF3 IKZF3 interactions 5.203E-5 2.318E-3 1.880E-2
9.734E-2
 3 112
43 int:CDK1 CDK1 interactions 6.131E-5 2.668E-3 2.164E-2
1.147E-1
 4 344
44 int:AZIN1 AZIN1 interactions 6.406E-5 2.724E-3 2.210E-2
1.199E-1
 2 18
45 int:ATR ATR interactions 7.047E-5 2.930E-3 2.377E-2
1.318E-1
 3 124
46 int:MRE11 MRE11 interactions 9.478E-5 3.844E-3 3.118E-2
1.773E-1
 3 137
47 int:IL6R IL6R interactions 9.657E-5 3.844E-3 3.118E-2
1.807E-1
 2 22
48 int:RMI1 RMI1 interactions 1.153E-4 4.494E-3 3.646E-2
2.157E-1
 2 24
49 int:XRCC3 XRCC3 interactions 1.447E-4 5.481E-3 4.446E-2
2.706E-1
 3 158
50 int:REV1 REV1 interactions 1.465E-4 5.481E-3 4.446E-2
2.740E-1
 2 27
Show 45 more annotations

10: Cytoband [Display Chart] 12 input genes in category / 12 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17q22.2 17q22.2 3.462E-4 4.154E-3 1.289E-2 4.155E-3 1 1
2 6p22-p21 6p22-p21 6.923E-4 4.154E-3 1.289E-2 8.308E-3 1 2
3 3p26 3p26 3.112E-3 1.244E-2 3.861E-2 3.734E-2 1 9
4 9q22.3 9q22.3 4.147E-3 1.244E-2 3.861E-2 4.977E-2 1 12
5 9p13 9p13 7.935E-3 1.904E-2
5.910E-2
9.522E-2
 1 23
6 2p16.1 2p16.1 1.102E-2 2.154E-2
6.684E-2
1.323E-1
 1 32
7 16p12.2 16p12.2 1.274E-2 2.154E-2
6.684E-2
1.528E-1
 1 37
8 Xp22.2 Xp22.2 1.445E-2 2.154E-2
6.684E-2
1.734E-1
 1 42
9 11p15 11p15 1.615E-2 2.154E-2
6.684E-2
1.938E-1
 1 47
10 16q24.3 16q24.3 1.922E-2 2.306E-2
7.157E-2
2.306E-1
 1 56
11 15q26.1 15q26.1 2.126E-2 2.319E-2
7.197E-2
2.551E-1
 1 62
Show 6 more annotations

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 37 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$E2F1 Q6 V$E2F1 Q6 2.072E-4 1.452E-3 6.102E-3 7.667E-3 3 181
2 V$E2F1DP2 01 V$E2F1DP2 01 2.176E-4 1.452E-3 6.102E-3 8.050E-3 3 184
3 V$E2F1DP1 01 V$E2F1DP1 01 2.176E-4 1.452E-3 6.102E-3 8.050E-3 3 184
4 V$E2F4DP2 01 V$E2F4DP2 01 2.176E-4 1.452E-3 6.102E-3 8.050E-3 3 184
5 V$E2F 02 V$E2F 02 2.176E-4 1.452E-3 6.102E-3 8.050E-3 3 184
6 V$E2F4DP1 01 V$E2F4DP1 01 2.355E-4 1.452E-3 6.102E-3 8.714E-3 3 189
7 SGCGSSAAA V$E2F1DP2 01 SGCGSSAAA V$E2F1DP2 01 3.585E-3 1.895E-2
7.962E-2
1.327E-1
 2 131
8 V$E2F1 Q4 01 V$E2F1 Q4 01 6.742E-3 2.261E-2
9.500E-2
2.495E-1
 2 181
9 V$E2F Q6 01 V$E2F Q6 01 6.961E-3 2.261E-2
9.500E-2
2.576E-1
 2 184
10 V$E2F Q4 01 V$E2F Q4 01 7.035E-3 2.261E-2
9.500E-2
2.603E-1
 2 185
11 V$E2F Q3 01 V$E2F Q3 01 7.109E-3 2.261E-2
9.500E-2
2.630E-1
 2 186
12 V$E2F1 Q6 01 V$E2F1 Q6 01 7.333E-3 2.261E-2
9.500E-2
2.713E-1
 2 189
Show 7 more annotations

12: Gene Family [Display Chart] 12 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 548 Fanconi anemia complementation groups genenames.org 4.603E-38 2.302E-37 5.255E-37 2.302E-37 12 20
2 1335 Fanconi anemia complementation groups|DNA helicases|BRCA1 B complex genenames.org 2.636E-3 6.590E-3 1.505E-2 1.318E-2 1 4
3 1167 INO80 complex |DNA helicases genenames.org 1.116E-2 1.860E-2 4.246E-2
5.579E-2
 1 17

13: Coexpression [Display Chart] 12 input genes in category / 830 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M12972 Genes identified with the Fanconi anemia (FA) and the FA pathway. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.314E-30 1.921E-27 1.402E-26 1.921E-27 9 11
2 19695104-AF1-3 Human Breast Lin09 10genes GeneSigDB 1.215E-19 5.040E-17 3.679E-16 1.008E-16 6 8
3 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.737E-16 4.806E-14 3.508E-13 1.442E-13 9 230
4 14993899-TableS1 Human Futreal04 427genes ConsensusCancerGenes GeneSigDB 1.629E-12 3.380E-10 2.467E-9 1.352E-9 8 364
5 M9575 DNA repair genes whose promoters contain putative ZNF143 [GeneID=7702] binding sites. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.484E-11 1.076E-8 7.856E-8 5.381E-8 5 58
6 19695104-AF2 Human Breast Lin09 128genes GeneSigDB 1.586E-10 2.194E-8 1.601E-7 1.316E-7 5 69
7 M1819 Meitic and DNA repair genes important for female fertility, based on mouse models with female fertility defects. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.378E-9 4.005E-7 2.923E-6 2.804E-6 4 39
8 M9150 Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.085E-9 5.716E-7 4.173E-6 5.051E-6 6 323
9 M2156 Genes up-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChem=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.199E-9 5.716E-7 4.173E-6 5.145E-6 6 324
10 M2431 DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.130E-8 1.768E-6 1.290E-5 1.768E-5 4 61
11 M9419 Genes up-regulated after poly(IC) injection: CD8A [GeneID=925] dendritic cells versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 2.540E-6 1.917E-4 1.399E-3 2.108E-3 4 200
12 17150101-TableS1h Human Breast Troester06 364genes up DOX-MCF7 GeneSigDB 9.901E-6 6.848E-4 4.999E-3 8.218E-3 4 282
13 M15356 Genes constituting the LIT-Int network of proteins interacting with breast cancer reference proteins BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200]; the interactions were manually curated from the literature. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.726E-5 1.102E-3 8.044E-3 1.433E-2 3 101
14 15489886-TableS1b Human Sarcoma Mason04 549genes GeneSigDB 6.956E-5 3.886E-3 2.836E-2
5.773E-2
 4 464
15 M2075 Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the S phase of cell cycle. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.077E-5 3.886E-3 2.836E-2
5.874E-2
 3 162
16 19043454-TableS2 Human Breast Thorner09 217genes GeneSigDB 7.746E-5 3.886E-3 2.836E-2
6.429E-2
 3 167
17 15548681-Table2 Human Breast Wang04 33genes GeneSigDB 7.959E-5 3.886E-3 2.836E-2
6.606E-2
 2 26
18 M2848 Genes down-regulated in MOLM-14 cells (AML) with knockdown of HOXA9 [Gene ID=3205] gene by RNAi vs controls. MSigDB C6: Oncogenic Signatures (v6.0) 1.189E-4 4.638E-3 3.386E-2
9.872E-2
 3 193
19 18338247-SuppTable4A Human Breast Harvell08 308genes GeneSigDB 1.245E-4 4.638E-3 3.386E-2
1.033E-1
 3 196
20 M7185 Genes up-regulated in transitional CR2 [GeneID=1380] high B lymphocytes versus those from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 1.322E-4 4.638E-3 3.386E-2
1.097E-1
 3 200
21 M5303 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from old donors versus those treated with TSST at 72 h. MSigDB C7: Immunologic Signatures (v6.0) 1.322E-4 4.638E-3 3.386E-2
1.097E-1
 3 200
22 M8109 Genes down-regulated in IL10 [GeneID=3586] knockout macrophages: unstimulated versus stimulated by IL10 [GeneID=3586] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.322E-4 4.638E-3 3.386E-2
1.097E-1
 3 200
23 M5292 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 40 h. MSigDB C7: Immunologic Signatures (v6.0) 1.322E-4 4.638E-3 3.386E-2
1.097E-1
 3 200
24 M14340 Genes down-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [GeneID=4904] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.341E-4 4.638E-3 3.386E-2
1.113E-1
 3 201
25 20035825-TableS8b Human Lung Mikkonen10 59genes GeneSigDB 1.999E-4 6.638E-3 4.845E-2
1.660E-1
 2 41
26 16886892-Table2 Human Breast Chalabi06 57genes GeneSigDB 2.520E-4 7.752E-3
5.658E-2
2.092E-1
 2 46
27 M11318 Genes down-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164], a marine-derived compound with potential anti-cancer properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.522E-4 7.752E-3
5.658E-2
2.093E-1
 3 249
28 16912175-SuppTable3a Human HeadandNeck Sengupta06 403genes GeneSigDB 3.864E-4 1.145E-2
8.360E-2
3.207E-1
 3 288
29 M15969 Cluster 1: genes up-regulated by RB1, CDNK2A [GeneID=1029;5925], and one of the E2Fs (E2F1, E2F2, or E2F3 [GeneID=1869;1870;1871]). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.840E-4 1.671E-2
1.220E-1
4.847E-1
 2 70
30 19139136-TableS2 Human Prostate John-Aryankalayil09 450genes GeneSigDB 6.217E-4 1.720E-2
1.256E-1
5.161E-1
 3 339
31 18662380-S3-AURKA Human Breast Wirapati08 355genes AURKA Module GeneSigDB 6.488E-4 1.737E-2
1.268E-1
5.385E-1
 3 344
32 M1916 Genes down-regulated in neural stem cells (NSC) at both 36 h and 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.417E-4 2.443E-2
1.783E-1
7.816E-1
 2 89
33 M9516 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.181E-3 2.969E-2
2.167E-1
9.799E-1
 3 423
34 M18855 Up-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.221E-3 2.981E-2
2.176E-1
1.000E0
 3 428
35 17150101-TableS1c Human Breast Troester06 134genes up DoxTreated-HME-CC GeneSigDB 1.357E-3 3.217E-2
2.348E-1
1.000E0
 2 107
36 M8520 Cluster 6 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts poor survival outcome. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.466E-3 3.379E-2
2.466E-1
1.000E0
 3 456
37 M2802 Genes up-regulated in primary keratinocytes from RB1 and RBL1 [Gene ID=5925, 5933] skin specific knockout mice. MSigDB C6: Oncogenic Signatures (v6.0) 2.274E-3 3.581E-2
2.614E-1
1.000E0
 2 139
38 M6085 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (2h) versus IL4 [GeneID=3565] (2h). MSigDB C7: Immunologic Signatures (v6.0) 2.274E-3 3.581E-2
2.614E-1
1.000E0
 2 139
39 M3045 Genes up-regulated in CD4+ [GeneID=920] T lymphocytes after stimulation with prostaglandin E2 [PubChem=5280360]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.504E-3 3.581E-2
2.614E-1
1.000E0
 2 146
40 M2114 Set 'Proliferation Cluster': genes defined in human breast tumor expression data. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.538E-3 3.581E-2
2.614E-1
1.000E0
 2 147
41 M438 Genes up-regulated in CAL1 cells (plasmacytoid dendritic cells) versus MOLT4 (immature T cells). MSigDB C7: Immunologic Signatures (v6.0) 2.675E-3 3.581E-2
2.614E-1
1.000E0
 2 151
42 M8235 Genes up-regulated in polarizing CD4 [GeneID=920] Th17 cells: wildtype versus RORC [GeneID=6097] knockout. MSigDB C7: Immunologic Signatures (v6.0) 3.034E-3 3.581E-2
2.614E-1
1.000E0
 2 161
43 M19957 Genes up-regulated in genomically unstable Ewing's sarcoma tumors compared to the stable ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.259E-3 3.581E-2
2.614E-1
1.000E0
 2 167
44 20068086-ST1-5 Human Breast Lee10 184genes GeneSigDB 3.375E-3 3.581E-2
2.614E-1
1.000E0
 2 170
45 M17193 Down-regulated genes distinguishing in multiple myeloma (MM) samples with lower expression of TACI [GeneID=23495]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.453E-3 3.581E-2
2.614E-1
1.000E0
 2 172
46 M6694 Genes down-regulated in endothelial cells: untreated versus interferon beta. MSigDB C7: Immunologic Signatures (v6.0) 3.492E-3 3.581E-2
2.614E-1
1.000E0
 2 173
47 M8990 Genes up-regulated in CD4 [GeneID=920] T cells treated with rosiglitazone [PubChem=77999] and over-expressing: FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943] and PPARg2 isoform of PPARG [GeneID=5468]. MSigDB C7: Immunologic Signatures (v6.0) 3.532E-3 3.581E-2
2.614E-1
1.000E0
 2 174
48 20035825-TableS7b Human Lung Mikkonen10 209genes GeneSigDB 3.572E-3 3.581E-2
2.614E-1
1.000E0
 2 175
49 18498629-GeneList Human Breast Loi08 239genes GeneSigDB 3.692E-3 3.581E-2
2.614E-1
1.000E0
 2 178
50 M6857 Genes up-regulated in spleens from mice immunized with ova peptides alone versus those immunized with monophosphoryl lipid A as adjuvant. MSigDB C7: Immunologic Signatures (v6.0) 3.774E-3 3.581E-2
2.614E-1
1.000E0
 2 180
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 12 input genes in category / 302 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap dev gonad e13.5 F MeioticGermCell Oct k2 500 dev gonad e13.5 F MeioticGermCell Oct k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.167E-8 3.524E-6 2.216E-5 3.524E-6 5 152
2 gudmap dev gonad e12.5 M GermCellTestis Oct k2 1000 dev gonad e12.5 M GermCellTestis Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.911E-7 2.445E-5 1.538E-4 5.772E-5 5 266
3 gudmap dev gonad e12.5 M GermCellTestis Oct k1 500 dev gonad e12.5 M GermCellTestis Oct k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.429E-7 2.445E-5 1.538E-4 7.335E-5 4 105
4 gudmap dev gonad e12.5 F GermCellOvary Oct k3 500 dev gonad e12.5 F GermCellOvary Oct k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.381E-7 2.553E-5 1.606E-4 1.021E-4 4 114
5 gudmap dev gonad e13.5 F MeioticGermCell Oct k2 1000 dev gonad e13.5 F MeioticGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 8.663E-7 5.232E-5 3.291E-4 2.616E-4 5 361
6 gudmap dev gonad e13.5 F MeioticGermCell Oct 500 dev gonad e13.5 F MeioticGermCell Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.189E-6 5.987E-5 3.765E-4 3.592E-4 5 385
7 gudmap dev gonad e12.5 F GermCellOvary Oct 500 dev gonad e12.5 F GermCellOvary Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.545E-6 6.664E-5 4.191E-4 4.664E-4 5 406
8 Sample Type by Project: Shred 1/TCGA-Bladder/Urothelial Carcinoma/Papillary Muscle Invasive Urothelial Carcinoma/2/4 Sample Type by Project: Shred 1/TCGA-Bladder/Urothelial Carcinoma/Papillary Muscle Invasive Urothelial Carcinoma/2/4 TCGA-Bladder 2.395E-6 9.041E-5 5.686E-4 7.233E-4 4 186
9 gudmap dev gonad e11.5 M PrimGermCell Oct k2 1000 dev gonad e11.5 M PrimGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 8.759E-6 2.939E-4 1.849E-3 2.645E-3 4 258
10 gudmap dev gonad e11.5 F PrimGermCell Oct k2 1000 dev gonad e11.5 F PrimGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.240E-5 6.640E-4 4.176E-3 6.765E-3 3 104
11 gudmap dev gonad e13.5 M GermCell Oct k1 1000 dev gonad e13.5 M GermCell Oct k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.418E-5 6.640E-4 4.176E-3 7.304E-3 4 334
12 gudmap dev gonad e11.5 F PrimGermCell Oct 500 dev gonad e11.5 F PrimGermCell Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.259E-5 9.994E-4 6.285E-3 1.286E-2 4 386
13 gudmap dev gonad e12.5 M GermCellTestis Oct 500 dev gonad e12.5 M GermCellTestis Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.302E-5 9.994E-4 6.285E-3 1.299E-2 4 387
14 GSM399452 500 B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3 Immgen.org, GSE15907 5.336E-5 1.085E-3 6.822E-3 1.612E-2 4 409
15 GSM538387 500 alpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 5.387E-5 1.085E-3 6.822E-3 1.627E-2 4 410
16 GSM399403 500 alpha beta T cells, T.ISP.Th, 4- 8+ TCR-/lo 24hi, Thymus, avg-3 Immgen.org, GSE15907 5.754E-5 1.086E-3 6.831E-3 1.738E-2 4 417
17 gudmap kidney e15.5 SmlBldVes Tie2 k3 1000 kidney e15.5 SmlBldVes Tie2 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.398E-4 4.260E-3 2.679E-2
7.242E-2
 3 231
18 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes 6.224E-4 9.398E-3
5.911E-2
1.880E-1
 3 320
19 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200 6.224E-4 9.398E-3
5.911E-2
1.880E-1
 3 320
20 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes BrainMap 6.224E-4 9.398E-3
5.911E-2
1.880E-1
 3 320
21 gudmap dev gonad e11.5 F PrimGermCell Oct k3 500 dev gonad e11.5 F PrimGermCell Oct k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.931E-4 9.968E-3
6.269E-2
2.093E-1
 2 72
22 GSM538207 500 B cells, B.GC.Sp, CD19+ IgM+ IgD- GL7+ PNA+, Spleen, avg-3 Immgen.org, GSE15907 1.024E-3 1.406E-2
8.845E-2
3.094E-1
 3 380
23 GSM791143 500 alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 1.162E-3 1.456E-2
9.156E-2
3.511E-1
 3 397
24 GSM399397 500 alpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3 Immgen.org, GSE15907 1.179E-3 1.456E-2
9.156E-2
3.562E-1
 3 399
25 GSM605898 500 alpha beta T cells, T.8Eff.Sp.OT1.d6.LisOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 1.205E-3 1.456E-2
9.156E-2
3.640E-1
 3 402
26 GSM476664 500 gamma delta T cells, Tgd.vg3+24alo.e17.Th, TCRd+ Vg3+ CD24-, Fetal Thymus, avg-3 Immgen.org, GSE15907 1.358E-3 1.495E-2
9.402E-2
4.101E-1
 3 419
27 GSM791141 500 alpha beta T cells, preT.DN2B.Th, Lin-/lo CD25hi CD44+ cKitint, Thymus, avg-2 Immgen.org, GSE15907 1.367E-3 1.495E-2
9.402E-2
4.129E-1
 3 420
28 GSM538357 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 1.386E-3 1.495E-2
9.402E-2
4.186E-1
 3 422
29 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Cap mesenchyme (CM)/late fetal/CM f Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Cap mesenchyme (CM)/late fetal/CM f Fetal, Development 1.908E-3 1.987E-2
1.250E-1
5.762E-1
 2 120
30 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gkn3/Endothelial Stalk.Flt1.Gkn3/Thalamus BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gkn3/Endothelial Stalk.Flt1.Gkn3/Thalamus BrainMap 2.167E-3 2.181E-2
1.372E-1
6.543E-1
 2 128
31 Facebase RNAseq e10.5 Lateral Nasal Eminence 500 K3 FacebaseRNAseq e10.5 Lateral Nasal Eminence top-relative-expression-ranked 500 k-means-cluster#3 FaceBase_RNAseq 2.406E-3 2.344E-2
1.474E-1
7.266E-1
 2 135
32 Cap mesenchyme (CM)/Cap mesenchyme (CM) f Cap mesenchyme (CM)/Cap mesenchyme (CM) f 5.089E-3 4.803E-2
3.021E-1
1.000E0
 2 198
Show 27 more annotations

15: Computational [Display Chart] 9 input genes in category / 83 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 12 input genes in category / 316 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-4268:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.738E-5 2.445E-2
1.549E-1
 2.445E-2 2 79
2 hsa-miR-1273:mirSVR highEffct hsa-miR-1273:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.748E-4 3.877E-2
2.456E-1
1.500E-1
 2 196
3 hsa-miR-6783-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.135E-4 3.877E-2
2.456E-1
1.939E-1
 2 223
4 hsa-miR-1343-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.135E-4 3.877E-2
2.456E-1
1.939E-1
 2 223
5 hsa-miR-505-3p:Functional MTI Functional MTI miRTarbase 6.135E-4 3.877E-2
2.456E-1
1.939E-1
 2 223
6 hsa-miR-4755-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.068E-3 4.303E-2
2.726E-1
3.374E-1
 2 295
7 hsa-miR-4664-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.328E-3 4.303E-2
2.726E-1
4.197E-1
 1 8
8 hsa-miR-1247-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.454E-3 4.303E-2
2.726E-1
4.595E-1
 2 345
9 hsa-miR-30e-5p:Functional MTI Functional MTI miRTarbase 1.471E-3 4.303E-2
2.726E-1
4.648E-1
 2 347
10 hsa-miR-886-5p:mirSVR lowEffct hsa-miR-886-5p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.590E-3 4.303E-2
2.726E-1
5.025E-1
 2 361
11 hsa-miR-30d-5p:Functional MTI Functional MTI miRTarbase 1.651E-3 4.303E-2
2.726E-1
5.218E-1
 2 368
12 hsa-miR-3194:mirSVR highEffct hsa-miR-3194:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.741E-3 4.303E-2
2.726E-1
5.501E-1
 2 378
13 hsa-miR-4286:mirSVR highEffct hsa-miR-4286:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.870E-3 4.303E-2
2.726E-1
5.909E-1
 2 392
14 hsa-miR-553:mirSVR highEffct hsa-miR-553:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.955E-3 4.303E-2
2.726E-1
6.179E-1
 2 401
15 hsa-miR-30b-5p:Functional MTI Functional MTI miRTarbase 2.102E-3 4.303E-2
2.726E-1
6.641E-1
 2 416
16 hsa-miR-744-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.304E-3 4.303E-2
2.726E-1
7.282E-1
 2 436
17 hsa-miR-611:mirSVR lowEffct hsa-miR-611:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.315E-3 4.303E-2
2.726E-1
7.315E-1
 2 437
18 hsa-miR-542-5p:mirSVR lowEffct hsa-miR-542-5p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.604E-3 4.342E-2
2.750E-1
8.227E-1
 2 464
19 hsa-miR-4284:mirSVR highEffct hsa-miR-4284:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.748E-3 4.342E-2
2.750E-1
8.685E-1
 2 477
20 hsa-miR-3141:mirSVR lowEffct hsa-miR-3141:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.794E-3 4.342E-2
2.750E-1
8.828E-1
 2 481
21 hsa-miR-210:mirSVR lowEffct hsa-miR-210:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 2.885E-3 4.342E-2
2.750E-1
9.118E-1
 2 489
22 CGCTGCT,MIR-503:MSigDB CGCTGCT,MIR-503:MSigDB MSigDB 3.152E-3 4.527E-2
2.868E-1
9.960E-1
 1 19
23 hsa-miR-6840-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.317E-3 4.558E-2
2.887E-1
1.000E0
 1 20
Show 18 more annotations

17: Drug [Display Chart] 12 input genes in category / 2177 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000004638 AC1L1IM7 Stitch 7.246E-30 1.577E-26 1.303E-25 1.577E-26 11 46
2 CID000004915 procarbazine Stitch 3.305E-26 3.597E-23 2.973E-22 7.195E-23 11 93
3 CID000121904 6-deoxyerythronolide B Stitch 5.391E-26 3.912E-23 3.233E-22 1.174E-22 11 97
4 CID000011254 diepoxybutane Stitch 3.149E-25 1.678E-22 1.387E-21 6.856E-22 11 113
5 CID004629339 AC1NDP1U Stitch 3.854E-25 1.678E-22 1.387E-21 8.390E-22 11 115
6 CID000002249 atenolol Stitch 7.598E-25 2.757E-22 2.278E-21 1.654E-21 11 122
7 CID000005746 mitomycin C Stitch 1.706E-21 5.305E-19 4.384E-18 3.714E-18 11 241
8 CID004631220 AC1NDT8D Stitch 4.878E-21 1.327E-18 1.097E-17 1.062E-17 8 34
9 CID000025440 Demetric acid Stitch 2.064E-20 4.993E-18 4.126E-17 4.493E-17 8 40
10 CID011968289 [(2S)-2-[(Z)-dodec-9-enoyl]oxy-3-tetradecanoyloxypropyl] [(2R,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl] phosphate Stitch 6.846E-19 1.490E-16 1.231E-15 1.490E-15 8 60
11 ctd:C471109 4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline CTD 2.497E-18 4.941E-16 4.083E-15 5.435E-15 7 30
12 CID000006235 Trenimon Stitch 1.268E-16 2.301E-14 1.901E-13 2.761E-13 6 19
13 ctd:C408982 CPG-oligonucleotide CTD 7.328E-15 1.227E-12 1.014E-11 1.595E-11 8 184
14 CID000004114 8-MOP Stitch 6.358E-14 9.886E-12 8.169E-11 1.384E-10 7 118
15 CID000175468 12-bromolaurate Stitch 1.682E-13 2.441E-11 2.017E-10 3.661E-10 6 57
16 CID000001292 PPCM Stitch 2.087E-13 2.840E-11 2.347E-10 4.544E-10 6 59
17 CID000002907 cyclophosphamide Stitch 7.632E-13 9.773E-11 8.076E-10 1.661E-9 8 327
18 CID000001642 AC1L1BWR Stitch 1.009E-12 1.220E-10 1.008E-9 2.196E-9 6 76
19 CID000002973 deferoxamine Stitch 1.120E-12 1.283E-10 1.060E-9 2.438E-9 8 343
20 CID000008420 2-naphthalenesulfonate Stitch 3.279E-12 3.569E-10 2.949E-9 7.138E-9 6 92
21 CID006433481 hygromycin A Stitch 5.815E-12 6.029E-10 4.982E-9 1.266E-8 6 101
22 CID005493470 NM-3 Stitch 4.777E-11 4.727E-9 3.906E-8 1.040E-7 5 54
23 CID000001800 5-amidinobenzimidazole Stitch 7.611E-11 7.204E-9 5.953E-8 1.657E-7 6 154
24 CID005323583 rufochromomycin Stitch 2.549E-9 2.312E-7 1.910E-6 5.549E-6 4 36
25 CID000446186 1i32 Stitch 4.078E-9 3.551E-7 2.934E-6 8.878E-6 5 129
26 CID000446057 1hef Stitch 4.376E-9 3.664E-7 3.027E-6 9.526E-6 4 41
27 CID000070065 Pb-D Stitch 6.855E-9 5.527E-7 4.567E-6 1.492E-5 5 143
28 CID000167827 fusigen Stitch 1.327E-8 1.006E-6 8.311E-6 2.888E-5 3 10
29 CID000004156 methyl methanesulfonate Stitch 1.340E-8 1.006E-6 8.311E-6 2.917E-5 6 364
30 CID000064960 1,5-AG Stitch 2.301E-8 1.661E-6 1.372E-5 5.010E-5 5 182
31 CID000023939 platinum Stitch 2.365E-8 1.661E-6 1.372E-5 5.149E-5 5 183
32 CID000134350 PADP Stitch 7.502E-8 5.104E-6 4.217E-5 1.633E-4 3 17
33 CID000001174 uracil Stitch 1.616E-7 1.066E-5 8.809E-5 3.518E-4 5 269
34 CID000656926 AC1LCVPZ Stitch 2.447E-7 1.567E-5 1.294E-4 5.326E-4 4 110
35 CID000019390 AC1L2E0P Stitch 3.113E-7 1.936E-5 1.600E-4 6.777E-4 5 307
36 CID005460240 tungstopterin Stitch 4.936E-7 2.985E-5 2.467E-4 1.075E-3 4 131
37 CID000065577 Topo Stitch 9.189E-7 5.407E-5 4.468E-4 2.001E-3 4 153
38 CID000063306 NU1025 Stitch 1.257E-6 7.203E-5 5.952E-4 2.737E-3 3 42
39 CID000001478 AC1L1BKI Stitch 1.660E-6 9.269E-5 7.659E-4 3.615E-3 3 46
40 CID000005192 sebacate Stitch 1.797E-6 9.779E-5 8.080E-4 3.912E-3 4 181
41 3283 DN Digoxin [20830-75-5]; Down 200; 5.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.046E-6 1.086E-4 8.976E-4 4.454E-3 4 187
42 CID000004199 minaprine Stitch 2.707E-6 1.403E-4 1.159E-3 5.893E-3 3 54
43 CID000409844 5H-purin-2-amine Stitch 1.847E-5 9.352E-4 7.728E-3 4.022E-2 3 102
44 ctd:D010042 Ouabain CTD 3.005E-5 1.463E-3 1.209E-2
6.543E-2
 3 120
45 CID000000671 d Na Stitch 3.024E-5 1.463E-3 1.209E-2
6.583E-2
 2 16
46 CID000000955 o-succinylbenzoic acid Stitch 3.853E-5 1.824E-3 1.507E-2
8.388E-2
 2 18
47 ctd:D016685 Mitomycin CTD 4.518E-5 2.093E-3 1.729E-2
9.836E-2
 4 410
48 CID000003657 hydroxyurea Stitch 5.844E-5 2.650E-3 2.190E-2
1.272E-1
 4 438
49 CID005289542 UV-C Stitch 7.487E-5 3.326E-3 2.749E-2
1.630E-1
 3 163
50 ctd:C007366 erythritol anhydride CTD 8.166E-5 3.486E-3 2.880E-2
1.778E-1
 2 26
Show 45 more annotations

18: Disease [Display Chart] 12 input genes in category / 296 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 cv:C1861028 Tracheoesophageal fistula Clinical Variations 4.311E-37 1.276E-34 8.000E-34 1.276E-34 12 21
2 C0272027 Pyridoxine-responsive sideroblastic anemia DisGeNET Curated 2.521E-26 3.731E-24 2.339E-23 7.461E-24 9 17
3 C4024780 Almond-shaped eyes DisGeNET Curated 3.235E-24 3.192E-22 2.001E-21 9.575E-22 9 26
4 C1859424 Increased chromosomal breakage DisGeNET Curated 4.852E-24 3.590E-22 2.251E-21 1.436E-21 9 27
5 C0014850 Esophageal Atresia DisGeNET Curated 1.036E-23 5.113E-22 3.205E-21 3.068E-21 9 29
6 C2749463 Radial aplasia/hypoplasia DisGeNET Curated 1.036E-23 5.113E-22 3.205E-21 3.068E-21 9 29
7 C0376628 Chromosome Breakage DisGeNET Curated 2.901E-23 1.227E-21 7.691E-21 8.587E-21 9 32
8 C1860236 Irregular hyperpigmentation DisGeNET Curated 3.988E-23 1.476E-21 9.251E-21 1.181E-20 9 33
9 OMIN:227650 FANCONI ANEMIA; FA OMIM 1.089E-22 3.583E-21 2.246E-20 3.224E-20 7 8
10 C0040588 Tracheoesophageal Fistula DisGeNET Curated 1.286E-22 3.805E-21 2.386E-20 3.805E-20 9 37
11 C3469521 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) DisGeNET Curated 1.539E-22 4.142E-21 2.596E-20 4.556E-20 12 252
12 C0423112 Short palpebral fissure DisGeNET Curated 1.684E-22 4.155E-21 2.605E-20 4.986E-20 9 38
13 C0015625 Fanconi Anemia DisGeNET Curated 6.953E-22 1.583E-20 9.925E-20 2.058E-19 12 285
14 C1836735 hypopigmented skin patch DisGeNET Curated 1.522E-20 3.218E-19 2.017E-18 4.505E-18 9 60
15 C0392386 Decreased platelet count DisGeNET Curated 5.607E-18 1.107E-16 6.937E-16 1.660E-15 9 112
16 C0023530 Leukopenia DisGeNET Curated 5.360E-15 9.916E-14 6.217E-13 1.587E-12 9 236
17 C0037932 Curvature of spine DisGeNET Curated 3.178E-14 5.534E-13 3.469E-12 9.407E-12 9 287
18 C0040034 Thrombocytopenia DisGeNET Curated 4.751E-14 7.813E-13 4.898E-12 1.406E-11 9 300
19 C0700208 Acquired scoliosis DisGeNET Curated 5.357E-14 8.346E-13 5.233E-12 1.586E-11 9 304
20 C4025639 Prolonged G2 phase of cell cycle DisGeNET Curated 1.723E-13 2.319E-12 1.454E-11 5.101E-11 4 4
21 C4025640 Deficient excision of UV-induced pyrimidine dimers in DNA DisGeNET Curated 1.723E-13 2.319E-12 1.454E-11 5.101E-11 4 4
22 C4025811 Anemic pallor DisGeNET Curated 1.723E-13 2.319E-12 1.454E-11 5.101E-11 4 4
23 C1849314 Absence of radius and ulna DisGeNET Curated 2.546E-13 3.277E-12 2.054E-11 7.537E-11 5 15
24 C0424688 Small head DisGeNET Curated 3.581E-13 4.059E-12 2.545E-11 1.060E-10 9 375
25 C3278811 Thumb aplasia DisGeNET Curated 3.702E-13 4.059E-12 2.545E-11 1.096E-10 5 16
26 C1405984 Absent radius DisGeNET Curated 3.702E-13 4.059E-12 2.545E-11 1.096E-10 5 16
27 C1838608 Radial aplasia DisGeNET Curated 3.702E-13 4.059E-12 2.545E-11 1.096E-10 5 16
28 C4021737 Chromosomal breakage induced by crosslinking agents DisGeNET Curated 8.613E-13 9.106E-12 5.709E-11 2.550E-10 4 5
29 C0162119 Hemoglobin low DisGeNET Curated 1.178E-12 1.202E-11 7.539E-11 3.487E-10 7 127
30 C3554724 Digitalization of thumbs DisGeNET Curated 2.583E-12 2.549E-11 1.598E-10 7.646E-10 4 6
31 C1858565 Duplicated collecting system DisGeNET Curated 6.025E-12 5.753E-11 3.606E-10 1.783E-9 4 7
32 C0265974 Birthmark DisGeNET Curated 2.733E-11 2.528E-10 1.585E-9 8.089E-9 5 35
33 C0858867 Reticulocytopenia DisGeNET Curated 3.611E-11 3.192E-10 2.001E-9 1.069E-8 4 10
34 C0221263 Cafe-au-Lait Spots DisGeNET Curated 3.667E-11 3.192E-10 2.001E-9 1.085E-8 5 37
35 C0542519 Congenital absence of kidney DisGeNET Curated 7.143E-11 6.041E-10 3.787E-9 2.114E-8 5 42
36 C0238207 Ectopic kidney DisGeNET Curated 8.504E-11 6.992E-10 4.383E-9 2.517E-8 4 12
37 C0002871 Anemia DisGeNET Curated 1.204E-10 9.631E-10 6.038E-9 3.563E-8 8 438
38 C0853697 Neutrophil count decreased DisGeNET Curated 1.435E-10 1.118E-9 7.007E-9 4.247E-8 5 48
39 C0221353 Horseshoe Kidney DisGeNET Curated 3.122E-10 2.369E-9 1.485E-8 9.240E-8 4 16
40 C1260926 Abnormal pigmentation DisGeNET Curated 2.162E-9 1.600E-8 1.003E-7 6.400E-7 4 25
41 C0431890 Hypoplasia of thumb DisGeNET Curated 2.997E-9 2.164E-8 1.357E-7 8.872E-7 4 27
42 C0030312 Pancytopenia DisGeNET Curated 8.315E-9 5.860E-8 3.674E-7 2.461E-6 5 106
43 C0346153 Breast Cancer, Familial DisGeNET Curated 3.893E-8 2.622E-7 1.644E-6 1.152E-5 5 144
44 C0948896 Primary hypogonadism DisGeNET Curated 3.897E-8 2.622E-7 1.644E-6 1.154E-5 4 50
45 C3160738 FANCONI ANEMIA, COMPLEMENTATION GROUP D2 DisGeNET Curated 8.836E-8 5.812E-7 3.644E-6 2.616E-5 3 13
46 C0423798 Increased tendency to bruise DisGeNET Curated 1.288E-7 8.114E-7 5.087E-6 3.814E-5 4 67
47 C0013491 Ecchymosis DisGeNET Curated 1.288E-7 8.114E-7 5.087E-6 3.814E-5 4 67
48 C0235991 Small for gestational age (disorder) DisGeNET Curated 1.452E-7 8.772E-7 5.499E-6 4.298E-5 4 69
49 C0024032 Low Birth Weights DisGeNET Curated 1.452E-7 8.772E-7 5.499E-6 4.298E-5 4 69
50 C0005859 Bloom Syndrome DisGeNET Curated 3.543E-7 2.097E-6 1.315E-5 1.049E-4 4 86
Show 45 more annotations