Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc33_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 38 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005126 cytokine receptor binding 9.054E-11 3.441E-9 1.455E-8 3.441E-9 6 289
2 GO:0005125 cytokine activity 4.692E-9 8.915E-8 3.769E-7 1.783E-7 5 222
3 GO:0005127 ciliary neurotrophic factor receptor binding 1.206E-6 1.527E-5 6.456E-5 4.581E-5 2 5
4 GO:0031726 CCR1 chemokine receptor binding 1.808E-6 1.603E-5 6.776E-5 6.870E-5 2 6
5 GO:0031730 CCR5 chemokine receptor binding 2.531E-6 1.603E-5 6.776E-5 9.617E-5 2 7
6 GO:0005138 interleukin-6 receptor binding 2.531E-6 1.603E-5 6.776E-5 9.617E-5 2 7
7 GO:0008083 growth factor activity 2.357E-5 1.280E-4 5.410E-4 8.957E-4 3 166
8 GO:0048020 CCR chemokine receptor binding 7.983E-5 3.792E-4 1.603E-3 3.034E-3 2 37
9 GO:0008009 chemokine activity 1.349E-4 5.697E-4 2.409E-3 5.128E-3 2 48
10 GO:0042379 chemokine receptor binding 2.113E-4 8.029E-4 3.395E-3 8.029E-3 2 60
11 GO:0005146 leukemia inhibitory factor receptor binding 7.501E-4 1.584E-3 6.695E-3 2.850E-2 1 2
12 GO:0019981 interleukin-6 binding 7.501E-4 1.584E-3 6.695E-3 2.850E-2 1 2
13 GO:0004923 leukemia inhibitory factor receptor activity 7.501E-4 1.584E-3 6.695E-3 2.850E-2 1 2
14 GO:0004915 interleukin-6 receptor activity 7.501E-4 1.584E-3 6.695E-3 2.850E-2 1 2
15 GO:0019970 interleukin-11 binding 7.501E-4 1.584E-3 6.695E-3 2.850E-2 1 2
16 GO:0004921 interleukin-11 receptor activity 7.501E-4 1.584E-3 6.695E-3 2.850E-2 1 2
17 GO:0001135 RNA polymerase II transcription regulator recruiting activity 7.501E-4 1.584E-3 6.695E-3 2.850E-2 1 2
18 GO:0045509 interleukin-27 receptor activity 7.501E-4 1.584E-3 6.695E-3 2.850E-2 1 2
19 GO:0004924 oncostatin-M receptor activity 1.125E-3 2.250E-3 9.513E-3 4.275E-2 1 3
20 GO:0070851 growth factor receptor binding 1.194E-3 2.269E-3 9.592E-3 4.538E-2 2 143
21 GO:0004897 ciliary neurotrophic factor receptor activity 1.500E-3 2.714E-3 1.147E-2
5.699E-2
 1 4
22 GO:0001134 transcription regulator recruiting activity 1.874E-3 3.238E-3 1.369E-2
7.123E-2
 1 5
23 GO:0030368 interleukin-17 receptor activity 2.998E-3 4.952E-3 2.094E-2
1.139E-1
 1 8
24 GO:0004698 calcium-dependent protein kinase C activity 4.120E-3 6.523E-3 2.758E-2
1.565E-1
 1 11
25 GO:0001664 G protein-coupled receptor binding 4.358E-3 6.567E-3 2.777E-2
1.656E-1
 2 276
26 GO:0016004 phospholipase activator activity 4.493E-3 6.567E-3 2.777E-2
1.707E-1
 1 12
27 GO:0060229 lipase activator activity 5.241E-3 7.376E-3 3.118E-2
1.991E-1
 1 14
28 GO:0009931 calcium-dependent protein serine/threonine kinase activity 6.734E-3 9.138E-3 3.864E-2
2.559E-1
 1 18
29 GO:0010857 calcium-dependent protein kinase activity 7.107E-3 9.312E-3 3.937E-2
2.700E-1
 1 19
30 GO:0004697 protein kinase C activity 8.970E-3 1.136E-2 4.803E-2
3.408E-1
 1 24
31 GO:0042056 chemoattractant activity 1.083E-2 1.327E-2
5.612E-2
4.115E-1
 1 29
32 GO:0004896 cytokine receptor activity 3.328E-2 3.952E-2
1.671E-1
1.000E0
 1 90
33 GO:0019955 cytokine binding 3.801E-2 4.377E-2
1.850E-1
1.000E0
 1 103
Show 28 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 846 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 4.130E-9 1.725E-6 1.262E-5 3.494E-6 4 63
2 GO:0048711 positive regulation of astrocyte differentiation 7.144E-9 1.725E-6 1.262E-5 6.044E-6 3 12
3 GO:0042509 regulation of tyrosine phosphorylation of STAT protein 9.365E-9 1.725E-6 1.262E-5 7.923E-6 4 77
4 GO:0007260 tyrosine phosphorylation of STAT protein 1.151E-8 1.725E-6 1.262E-5 9.736E-6 4 81
5 GO:0070372 regulation of ERK1 and ERK2 cascade 1.243E-8 1.725E-6 1.262E-5 1.051E-5 5 269
6 GO:0046427 positive regulation of JAK-STAT cascade 1.468E-8 1.725E-6 1.262E-5 1.242E-5 4 86
7 GO:1904894 positive regulation of STAT cascade 1.468E-8 1.725E-6 1.262E-5 1.242E-5 4 86
8 GO:0070371 ERK1 and ERK2 cascade 1.631E-8 1.725E-6 1.262E-5 1.380E-5 5 284
9 GO:0050727 regulation of inflammatory response 4.074E-8 3.830E-6 2.803E-5 3.447E-5 5 341
10 GO:0050729 positive regulation of inflammatory response 8.302E-8 7.024E-6 5.140E-5 7.024E-5 4 132
11 GO:0048710 regulation of astrocyte differentiation 1.315E-7 1.011E-5 7.399E-5 1.112E-4 3 30
12 GO:0046425 regulation of JAK-STAT cascade 1.800E-7 1.172E-5 8.574E-5 1.523E-4 4 160
13 GO:1904892 regulation of STAT cascade 1.800E-7 1.172E-5 8.574E-5 1.523E-4 4 160
14 GO:1903034 regulation of response to wounding 2.062E-7 1.246E-5 9.120E-5 1.745E-4 5 472
15 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 2.700E-7 1.523E-5 1.114E-4 2.284E-4 4 177
16 GO:0045687 positive regulation of glial cell differentiation 2.955E-7 1.562E-5 1.143E-4 2.500E-4 3 39
17 GO:1903036 positive regulation of response to wounding 3.438E-7 1.564E-5 1.145E-4 2.909E-4 4 188
18 GO:0007259 JAK-STAT cascade 3.512E-7 1.564E-5 1.145E-4 2.971E-4 4 189
19 GO:0097696 STAT cascade 3.512E-7 1.564E-5 1.145E-4 2.971E-4 4 189
20 GO:0030278 regulation of ossification 4.959E-7 2.098E-5 1.535E-4 4.195E-4 4 206
21 GO:0048861 leukemia inhibitory factor signaling pathway 7.264E-7 2.926E-5 2.142E-4 6.145E-4 2 4
22 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 9.134E-7 3.513E-5 2.571E-4 7.728E-4 4 240
23 GO:0014015 positive regulation of gliogenesis 1.159E-6 4.087E-5 2.991E-4 9.809E-4 3 61
24 GO:0002548 monocyte chemotaxis 1.159E-6 4.087E-5 2.991E-4 9.809E-4 3 61
25 GO:0042063 gliogenesis 1.666E-6 5.554E-5 4.065E-4 1.409E-3 4 279
26 GO:2000503 positive regulation of natural killer cell chemotaxis 1.815E-6 5.554E-5 4.065E-4 1.536E-3 2 6
27 GO:0045685 regulation of glial cell differentiation 1.838E-6 5.554E-5 4.065E-4 1.555E-3 3 71
28 GO:0048708 astrocyte differentiation 1.838E-6 5.554E-5 4.065E-4 1.555E-3 3 71
29 GO:0032103 positive regulation of response to external stimulus 3.172E-6 9.252E-5 6.771E-4 2.683E-3 4 328
30 GO:0002690 positive regulation of leukocyte chemotaxis 3.284E-6 9.260E-5 6.777E-4 2.778E-3 3 86
31 GO:2000501 regulation of natural killer cell chemotaxis 4.354E-6 1.188E-4 8.697E-4 3.684E-3 2 9
32 GO:0071347 cellular response to interleukin-1 4.722E-6 1.248E-4 9.137E-4 3.995E-3 3 97
33 GO:0018108 peptidyl-tyrosine phosphorylation 5.992E-6 1.521E-4 1.113E-3 5.069E-3 4 385
34 GO:0018212 peptidyl-tyrosine modification 6.116E-6 1.521E-4 1.113E-3 5.174E-3 4 387
35 GO:0002688 regulation of leukocyte chemotaxis 6.347E-6 1.521E-4 1.113E-3 5.370E-3 3 107
36 GO:0070102 interleukin-6-mediated signaling pathway 6.650E-6 1.521E-4 1.113E-3 5.626E-3 2 11
37 GO:0035747 natural killer cell chemotaxis 6.650E-6 1.521E-4 1.113E-3 5.626E-3 2 11
38 GO:0001503 ossification 7.253E-6 1.580E-4 1.156E-3 6.136E-3 4 404
39 GO:0014013 regulation of gliogenesis 7.283E-6 1.580E-4 1.156E-3 6.161E-3 3 112
40 GO:0043922 negative regulation by host of viral transcription 7.979E-6 1.672E-4 1.224E-3 6.750E-3 2 12
41 GO:1903532 positive regulation of secretion by cell 8.222E-6 1.672E-4 1.224E-3 6.956E-3 4 417
42 GO:0001819 positive regulation of cytokine production 8.300E-6 1.672E-4 1.224E-3 7.022E-3 4 418
43 GO:0031349 positive regulation of defense response 9.031E-6 1.777E-4 1.300E-3 7.640E-3 4 427
44 GO:0070555 response to interleukin-1 9.890E-6 1.902E-4 1.392E-3 8.367E-3 3 124
45 GO:0030335 positive regulation of cell migration 1.063E-5 1.999E-4 1.463E-3 8.996E-3 4 445
46 GO:0051047 positive regulation of secretion 1.111E-5 2.005E-4 1.467E-3 9.402E-3 4 450
47 GO:0002687 positive regulation of leukocyte migration 1.114E-5 2.005E-4 1.467E-3 9.422E-3 3 129
48 GO:0050921 positive regulation of chemotaxis 1.140E-5 2.009E-4 1.470E-3 9.643E-3 3 130
49 GO:2000147 positive regulation of cell motility 1.192E-5 2.057E-4 1.506E-3 1.008E-2 4 458
50 GO:0050769 positive regulation of neurogenesis 1.265E-5 2.077E-4 1.520E-3 1.070E-2 4 465
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 11 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005896 interleukin-6 receptor complex 3.468E-7 3.814E-6 1.152E-5 3.814E-6 2 3
2 GO:0097059 CNTFR-CLCF1 complex 7.344E-4 2.423E-3 7.317E-3 8.078E-3 1 2
3 GO:0005900 oncostatin-M receptor complex 7.344E-4 2.423E-3 7.317E-3 8.078E-3 1 2
4 GO:0097058 CRLF-CLCF1 complex 1.101E-3 2.423E-3 7.317E-3 1.212E-2 1 3
5 GO:0070110 ciliary neurotrophic factor receptor complex 1.101E-3 2.423E-3 7.317E-3 1.212E-2 1 3
6 GO:0098802 plasma membrane receptor complex 1.805E-3 3.310E-3 9.995E-3 1.986E-2 2 180
7 GO:0009897 external side of plasma membrane 5.246E-3 8.243E-3 2.489E-2
5.770E-2
 2 310
8 GO:0043235 receptor complex 6.243E-3 8.584E-3 2.592E-2
6.867E-2
 2 339
9 GO:0032809 neuronal cell body membrane 1.060E-2 1.166E-2 3.522E-2
1.166E-1
 1 29
10 GO:0044298 cell body membrane 1.060E-2 1.166E-2 3.522E-2
1.166E-1
 1 29
Show 5 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 626 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 5 input genes in category / 674 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0006271 abnormal involution of the mammary gland 1.968E-7 8.168E-5 5.792E-4 1.326E-4 3 29
2 MP:0010119 abnormal bone mineral density 2.424E-7 8.168E-5 5.792E-4 1.634E-4 5 494
3 MP:0002998 abnormal bone remodeling 6.010E-7 1.350E-4 9.574E-4 4.051E-4 4 195
4 MP:0001541 abnormal osteoclast physiology 4.228E-6 7.123E-4 5.051E-3 2.849E-3 3 79
5 MP:0008396 abnormal osteoclast differentiation 6.701E-6 9.033E-4 6.405E-3 4.516E-3 3 92
6 MP:0000134 abnormal compact bone thickness 1.812E-5 2.035E-3 1.443E-2 1.221E-2 3 128
7 MP:0008595 abnormal circulating interleukin-6 level 2.690E-5 2.313E-3 1.640E-2 1.813E-2 3 146
8 MP:0000062 increased bone mineral density 2.745E-5 2.313E-3 1.640E-2 1.850E-2 3 147
9 MP:0000628 abnormal mammary gland development 3.156E-5 2.364E-3 1.676E-2 2.127E-2 3 154
10 MP:0004986 abnormal osteoblast morphology 3.539E-5 2.385E-3 1.692E-2 2.385E-2 3 160
11 MP:0004808 abnormal hematopoietic stem cell morphology 4.096E-5 2.510E-3 1.780E-2 2.761E-2 3 168
12 MP:0010211 abnormal acute phase protein level 5.127E-5 2.743E-3 1.945E-2 3.455E-2 2 24
13 MP:0003797 abnormal compact bone morphology 5.290E-5 2.743E-3 1.945E-2 3.566E-2 3 183
14 MP:0004982 abnormal osteoclast morphology 5.826E-5 2.805E-3 1.989E-2 3.927E-2 3 189
15 MP:0002182 abnormal astrocyte morphology 6.796E-5 2.955E-3 2.096E-2 4.580E-2 3 199
16 MP:0001728 failure of embryo implantation 7.016E-5 2.955E-3 2.096E-2 4.729E-2 2 28
17 MP:0003724 increased susceptibility to induced arthritis 1.234E-4 4.620E-3 3.276E-2
8.317E-2
 2 37
18 MP:0002658 abnormal liver regeneration 1.234E-4 4.620E-3 3.276E-2
8.317E-2
 2 37
19 MP:0008588 abnormal circulating interleukin level 1.374E-4 4.620E-3 3.276E-2
9.259E-2
 3 252
20 MP:0000627 abnormal mammary gland morphology 1.440E-4 4.620E-3 3.276E-2
9.703E-2
 3 256
21 MP:0013554 abnormal apocrine gland morphology 1.440E-4 4.620E-3 3.276E-2
9.703E-2
 3 256
22 MP:0008874 decreased physiological sensitivity to xenobiotic 2.022E-4 6.194E-3 4.392E-2
1.363E-1
 3 287
23 MP:0009347 increased trabecular bone thickness 2.174E-4 6.216E-3 4.408E-2
1.465E-1
 2 49
24 MP:0008751 abnormal interleukin level 2.216E-4 6.216E-3 4.408E-2
1.493E-1
 3 296
25 MP:0000130 abnormal trabecular bone morphology 2.306E-4 6.216E-3 4.408E-2
1.554E-1
 3 300
26 MP:0008597 decreased circulating interleukin-6 level 2.843E-4 7.370E-3
5.226E-2
1.916E-1
 2 56
27 MP:0010210 abnormal circulating cytokine level 3.169E-4 7.630E-3
5.410E-2
2.136E-1
 3 334
28 MP:0002498 abnormal acute inflammation 3.254E-4 7.630E-3
5.410E-2
2.193E-1
 3 337
29 MP:0000952 abnormal CNS glial cell morphology 3.283E-4 7.630E-3
5.410E-2
2.213E-1
 3 338
30 MP:0008813 decreased common myeloid progenitor cell number 3.716E-4 8.334E-3
5.910E-2
2.504E-1
 2 64
31 MP:0001727 abnormal embryo implantation 3.833E-4 8.334E-3
5.910E-2
2.583E-1
 2 65
32 MP:0001807 decreased IgA level 4.195E-4 8.564E-3
6.073E-2
2.828E-1
 2 68
33 MP:0005006 abnormal osteoblast physiology 4.446E-4 8.564E-3
6.073E-2
2.997E-1
 2 70
34 MP:0008735 increased susceptibility to endotoxin shock 4.574E-4 8.564E-3
6.073E-2
3.083E-1
 2 71
35 MP:0010270 decreased stomach tumor incidence 4.829E-4 8.564E-3
6.073E-2
3.254E-1
 1 1
36 MP:0009665 abnormal embryo apposition 4.829E-4 8.564E-3
6.073E-2
3.254E-1
 1 1
37 MP:0030480 decreased osteocyte apoptosis 4.829E-4 8.564E-3
6.073E-2
3.254E-1
 1 1
38 MP:0030442 decreased osteoblast apoptosis 4.829E-4 8.564E-3
6.073E-2
3.254E-1
 1 1
39 MP:0008973 decreased erythroid progenitor cell number 5.241E-4 9.057E-3
6.423E-2
3.532E-1
 2 76
40 MP:0001542 abnormal bone strength 5.379E-4 9.064E-3
6.428E-2
3.626E-1
 2 77
41 MP:0004984 increased osteoclast cell number 5.520E-4 9.074E-3
6.435E-2
3.720E-1
 2 78
42 MP:0008734 decreased susceptibility to endotoxin shock 5.806E-4 9.318E-3
6.607E-2
3.913E-1
 2 80
43 MP:0008500 increased IgG2a level 6.100E-4 9.561E-3
6.780E-2
4.111E-1
 2 82
44 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality 6.400E-4 9.804E-3
6.952E-2
4.314E-1
 2 84
45 MP:0000939 decreased motor neuron number 6.708E-4 9.844E-3
6.981E-2
4.521E-1
 2 86
46 MP:0003634 abnormal glial cell morphology 6.772E-4 9.844E-3
6.981E-2
4.564E-1
 3 432
47 MP:0002451 abnormal macrophage physiology 6.865E-4 9.844E-3
6.981E-2
4.627E-1
 3 434
48 MP:0008713 abnormal cytokine level 7.100E-4 9.969E-3
7.069E-2
4.785E-1
 3 439
49 MP:0008271 abnormal bone ossification 7.487E-4 1.022E-2
7.250E-2
5.046E-1
 3 447
50 MP:0002406 increased susceptibility to infection 7.586E-4 1.022E-2
7.250E-2
5.113E-1
 3 449
Show 45 more annotations

6: Domain [Display Chart] 6 input genes in category / 39 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1.20.1250.10 - Gene3D 3.557E-7 7.369E-6 3.134E-5 1.387E-5 3 50
2 IPR012351 4 helix cytokine core InterPro 3.779E-7 7.369E-6 3.134E-5 1.474E-5 3 51
3 IPR009079 4 helix cytokine-like core InterPro 1.173E-6 1.525E-5 6.487E-5 4.575E-5 3 74
4 IPR015665 SOST InterPro 3.203E-4 1.315E-3 5.592E-3 1.249E-2 1 1
5 IPR003574 IL-6 InterPro 3.203E-4 1.315E-3 5.592E-3 1.249E-2 1 1
6 IPR003624 Leukemia IF InterPro 3.203E-4 1.315E-3 5.592E-3 1.249E-2 1 1
7 SM00080 LIF OSM SMART 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
8 PF06875 PRF Pfam 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
9 IPR001581 Leukemia IF/oncostatin InterPro 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
10 IPR019827 Leukemia IF/oncostatin CS InterPro 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
11 IPR030474 IL-6/GCSF/MGF InterPro 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
12 SM00126 IL6 SMART 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
13 IPR008835 Sclerostin/SOSTDC1 InterPro 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
14 PF05463 Sclerostin Pfam 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
15 IPR030473 IL6/GCSF/MGF CS InterPro 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
16 PF01291 LIF OSM Pfam 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
17 PS00590 LIF OSM PROSITE 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
18 IPR010681 PRF InterPro 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
19 PS00254 INTERLEUKIN 6 PROSITE 6.404E-4 1.315E-3 5.592E-3 2.498E-2 1 2
20 PF00489 IL6 Pfam 9.605E-4 1.873E-3 7.967E-3 3.746E-2 1 3
21 IPR010457 IgC2-like lig-bd InterPro 1.281E-3 2.270E-3 9.656E-3 4.994E-2 1 4
22 PF06328 Lep receptor Ig Pfam 1.281E-3 2.270E-3 9.656E-3 4.994E-2 1 4
23 IPR003529 Hematopoietin rcpt Gp130 CS InterPro 2.240E-3 3.798E-3 1.616E-2
8.736E-2
 1 7
24 PS01353 HEMATOPO REC L F2 PROSITE 2.560E-3 4.159E-3 1.769E-2
9.983E-2
 1 8
25 IPR015321 TypeI recpt CBD InterPro 3.518E-3 5.277E-3 2.245E-2
1.372E-1
 1 11
26 PF09240 IL6Ra-bind Pfam 3.518E-3 5.277E-3 2.245E-2
1.372E-1
 1 11
27 PS01185 CTCK 1 PROSITE 5.752E-3 8.308E-3 3.534E-2
2.243E-1
 1 18
28 SM00041 CT SMART 7.026E-3 9.786E-3 4.163E-2
2.740E-1
 1 22
29 IPR006207 Cys knot C InterPro 7.981E-3 1.011E-2 4.302E-2
3.113E-1
 1 25
30 PS01225 CTCK 2 PROSITE 7.981E-3 1.011E-2 4.302E-2
3.113E-1
 1 25
31 PS00472 SMALL CYTOKINES CC PROSITE 8.299E-3 1.011E-2 4.302E-2
3.237E-1
 1 26
32 IPR000827 Chemokine CC CS InterPro 8.299E-3 1.011E-2 4.302E-2
3.237E-1
 1 26
33 SM00199 SCY SMART 1.338E-2 1.561E-2
6.641E-2
5.217E-1
 1 42
34 PF00048 IL8 Pfam 1.401E-2 1.561E-2
6.641E-2
5.464E-1
 1 44
35 IPR001811 Chemokine IL8-like dom InterPro 1.401E-2 1.561E-2
6.641E-2
5.464E-1
 1 44
Show 30 more annotations

7: Pathway [Display Chart] 7 input genes in category / 88 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1339142 Interleukin-6 family signaling BioSystems: REACTOME 6.112E-10 2.978E-8 1.507E-7 5.378E-8 4 27
2 83051 Cytokine-cytokine receptor interaction BioSystems: KEGG 6.769E-10 2.978E-8 1.507E-7 5.957E-8 6 270
3 1470924 Interleukin-10 signaling BioSystems: REACTOME 7.347E-9 2.155E-7 1.091E-6 6.465E-7 4 49
4 1339143 IL-6-type cytokine receptor ligand interactions BioSystems: REACTOME 1.236E-7 2.719E-6 1.376E-5 1.087E-5 3 20
5 M5883 Genes encoding secreted soluble factors MSigDB C2 BIOCARTA (v6.0) 3.140E-7 5.526E-6 2.796E-5 2.763E-5 5 344
6 1269505 MAPK1 (ERK2) activation BioSystems: REACTOME 9.737E-6 1.339E-4 6.773E-4 8.569E-4 2 9
7 375172 Salmonella infection BioSystems: KEGG 1.092E-5 1.339E-4 6.773E-4 9.608E-4 3 86
8 1269504 MAPK3 (ERK1) activation BioSystems: REACTOME 1.217E-5 1.339E-4 6.773E-4 1.071E-3 2 10
9 1269325 Interleukin-6 signaling BioSystems: REACTOME 1.487E-5 1.454E-4 7.356E-4 1.308E-3 2 11
10 83076 Toll-like receptor signaling pathway BioSystems: KEGG 1.934E-5 1.702E-4 8.614E-4 1.702E-3 3 104
11 M9367 Erythrocyte Differentiation Pathway MSigDB C2 BIOCARTA (v6.0) 2.835E-5 2.268E-4 1.148E-3 2.495E-3 2 15
12 M5489 IL 6 signaling pathway MSigDB C2 BIOCARTA (v6.0) 6.226E-5 4.000E-4 2.024E-3 5.479E-3 2 22
13 M18719 Role of ERBB2 in Signal Transduction and Oncology MSigDB C2 BIOCARTA (v6.0) 6.226E-5 4.000E-4 2.024E-3 5.479E-3 2 22
14 83077 Jak-STAT signaling pathway BioSystems: KEGG 6.510E-5 4.000E-4 2.024E-3 5.729E-3 3 156
15 1269503 RAF-independent MAPK1/3 activation BioSystems: REACTOME 6.817E-5 4.000E-4 2.024E-3 5.999E-3 2 23
16 137929 IL27-mediated signaling events BioSystems: Pathway Interaction Database 8.751E-5 4.813E-4 2.435E-3 7.701E-3 2 26
17 M4047 Selective expression of chemokine receptors during T-cell polarization MSigDB C2 BIOCARTA (v6.0) 1.092E-4 5.654E-4 2.861E-3 9.612E-3 2 29
18 169349 Validated transcriptional targets of AP1 family members Fra1 and Fra2 BioSystems: Pathway Interaction Database 1.507E-4 7.369E-4 3.729E-3 1.326E-2 2 34
19 137932 IL6-mediated signaling events BioSystems: Pathway Interaction Database 2.420E-4 1.121E-3 5.672E-3 2.130E-2 2 43
20 137922 IL12-mediated signaling events BioSystems: Pathway Interaction Database 4.881E-4 2.148E-3 1.087E-2 4.295E-2 2 61
21 125137 Cytosolic DNA-sensing pathway BioSystems: KEGG 5.373E-4 2.249E-3 1.138E-2 4.728E-2 2 64
22 PW:0000516 Interleukin-6 signaling Pathway Ontology 5.622E-4 2.249E-3 1.138E-2 4.948E-2 1 1
23 200309 Rheumatoid arthritis BioSystems: KEGG 1.060E-3 4.056E-3 2.052E-2
9.328E-2
 2 90
24 P00036 Interleukin signaling pathway PantherDB 1.107E-3 4.060E-3 2.054E-2
9.744E-2
 2 92
25 147809 Chagas disease (American trypanosomiasis) BioSystems: KEGG 1.359E-3 4.783E-3 2.420E-2
1.196E-1
 2 102
26 1469482 Th17 cell differentiation BioSystems: KEGG 1.494E-3 4.960E-3 2.510E-2
1.315E-1
 2 107
27 812256 TNF signaling pathway BioSystems: KEGG 1.522E-3 4.960E-3 2.510E-2
1.339E-1
 2 108
28 1470923 Interleukin-4 and 13 signaling BioSystems: REACTOME 1.694E-3 5.323E-3 2.694E-2
1.491E-1
 2 114
29 1026136 Signaling pathways regulating pluripotency of stem cells BioSystems: KEGG 2.505E-3 7.602E-3 3.847E-2
2.205E-1
 2 139
30 99051 Chemokine signaling pathway BioSystems: KEGG 4.253E-3 1.248E-2
6.313E-2
3.743E-1
 2 182
31 P00031 Inflammation mediated by chemokine and cytokine signaling pathway PantherDB 4.674E-3 1.327E-2
6.714E-2
4.113E-1
 2 191
32 M18928 IL 5 Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 5.610E-3 1.543E-2
7.807E-2
4.937E-1
 1 10
33 M9174 STAT3 Pathway MSigDB C2 BIOCARTA (v6.0) 6.170E-3 1.645E-2
8.326E-2
5.429E-1
 1 11
34 1269502 MAPK1/MAPK3 signaling BioSystems: REACTOME 8.137E-3 2.055E-2
1.040E-1
7.161E-1
 2 254
35 M5298 Regulation of hematopoiesis by cytokines MSigDB C2 BIOCARTA (v6.0) 8.405E-3 2.055E-2
1.040E-1
7.397E-1
 1 15
36 1269608 Negative regulation of TCF-dependent signaling by WNT ligand antagonists BioSystems: REACTOME 8.405E-3 2.055E-2
1.040E-1
7.397E-1
 1 15
37 M6778 IL-10 Anti-inflammatory Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 9.521E-3 2.148E-2
1.087E-1
8.379E-1
 1 17
38 M19422 IL 17 Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 9.521E-3 2.148E-2
1.087E-1
8.379E-1
 1 17
39 M3952 Cells and Molecules involved in local acute inflammatory response MSigDB C2 BIOCARTA (v6.0) 9.521E-3 2.148E-2
1.087E-1
8.379E-1
 1 17
40 M2349 Pertussis toxin-insensitive CCR5 Signaling in Macrophage MSigDB C2 BIOCARTA (v6.0) 1.008E-2 2.217E-2
1.122E-1
8.870E-1
 1 18
41 1269501 MAPK family signaling cascades BioSystems: REACTOME 1.072E-2 2.301E-2
1.164E-1
9.433E-1
 2 293
42 M17406 Cytokine Network MSigDB C2 BIOCARTA (v6.0) 1.175E-2 2.462E-2
1.246E-1
1.000E0
 1 21
43 M6910 Cytokines and Inflammatory Response MSigDB C2 BIOCARTA (v6.0) 1.620E-2 3.314E-2
1.677E-1
1.000E0
 1 29
44 1440526 Antifolate resistance BioSystems: KEGG 1.730E-2 3.461E-2
1.751E-1
1.000E0
 1 31
45 M12095 Signal transduction through IL1R MSigDB C2 BIOCARTA (v6.0) 1.841E-2 3.601E-2
1.822E-1
1.000E0
 1 33
46 101144 Prion diseases BioSystems: KEGG 1.952E-2 3.654E-2
1.849E-1
1.000E0
 1 35
47 194384 African trypanosomiasis BioSystems: KEGG 1.952E-2 3.654E-2
1.849E-1
1.000E0
 1 35
48 138000 IL23-mediated signaling events BioSystems: Pathway Interaction Database 2.062E-2 3.781E-2
1.913E-1
1.000E0
 1 37
49 83124 Graft-versus-host disease BioSystems: KEGG 2.283E-2 4.100E-2
2.075E-1
1.000E0
 1 41
50 137945 amb2 Integrin signaling BioSystems: Pathway Interaction Database 2.668E-2 4.609E-2
2.332E-1
1.000E0
 1 48
Show 45 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 7507 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18346864 Type C coping, alexithymia, and heart rate reactivity are associated independently and differentially with specific immune mechanisms linked to HIV progression. Pubmed 1.508E-11 8.083E-8 7.680E-7 1.132E-7 3 4
2 17979974 Interleukin-6 cytokine family member oncostatin M is a hair-follicle-expressed factor with hair growth inhibitory properties. Pubmed 3.769E-11 8.083E-8 7.680E-7 2.829E-7 3 5
3 25008917 Effect of vaginal immunization with HIVgp140 and HSP70 on HIV-1 replication and innate and T cell adaptive immunity in women. Pubmed 7.538E-11 8.083E-8 7.680E-7 5.658E-7 3 6
4 20817073 HIV-1 infection inhibits cytokine production in human thymic macrophages. Pubmed 7.538E-11 8.083E-8 7.680E-7 5.658E-7 3 6
5 12574335 HIV-1 Nef induces the release of inflammatory factors from human monocyte/macrophages: involvement of Nef endocytotic signals and NF-kappa B activation. Pubmed 7.538E-11 8.083E-8 7.680E-7 5.658E-7 3 6
6 22156348 IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes. Pubmed 7.538E-11 8.083E-8 7.680E-7 5.658E-7 3 6
7 20482449 Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study. Pubmed 7.538E-11 8.083E-8 7.680E-7 5.658E-7 3 6
8 12370346 Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells. Pubmed 1.319E-10 1.100E-7 1.045E-6 9.901E-7 3 7
9 12643274 Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. Pubmed 1.319E-10 1.100E-7 1.045E-6 9.901E-7 3 7
10 12089333 HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication. Pubmed 2.343E-10 1.759E-7 1.671E-6 1.759E-6 4 63
11 23554973 HIV-1 gp120 protein downregulates Nef induced IL-6 release in immature dentritic cells through interplay of DC-SIGN. Pubmed 4.521E-10 3.085E-7 2.931E-6 3.394E-6 3 10
12 25529283 Nef, the shuttling molecular adaptor of HIV, influences the cytokine network. Pubmed 6.216E-10 3.889E-7 3.695E-6 4.666E-6 3 11
13 22407921 HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages. Pubmed 8.287E-10 4.786E-7 4.547E-6 6.221E-6 3 12
14 25240755 Loading dendritic cells with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses. Pubmed 2.561E-9 1.373E-6 1.304E-5 1.922E-5 3 17
15 16160188 Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells. Pubmed 5.797E-9 2.901E-6 2.756E-5 4.352E-5 3 22
16 20380698 Macrophage signaling in HIV-1 infection. Pubmed 6.666E-9 3.127E-6 2.971E-5 5.004E-5 3 23
17 9658081 Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway. Pubmed 9.783E-9 4.157E-6 3.949E-5 7.344E-5 3 26
18 15481145 Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis. Pubmed 1.233E-8 4.157E-6 3.949E-5 9.253E-5 3 28
19 22520363 Assessment of leukemia inhibitory factor and glycoprotein 130 expression in endometrium and uterine flushing: a possible diagnostic tool for impaired fertility. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
20 19074730 High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
21 17848619 Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
22 12509437 Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
23 24712547 Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
24 18714032 Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
25 29705123 The association of CCL3 and CCL4 polymorphisms with HCV clearance in Chinese Han population. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
26 26384383 Mesenteric Fat Lipolysis Mediates Obesity-Associated Hepatic Steatosis and Insulin Resistance. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
27 10470075 HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
28 19342884 Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
29 12830005 Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
30 21030011 Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
31 12603824 Interleukin-1beta stimulates macrophage inflammatory protein-1alpha and -1beta expression in human neuronal cells (NT2-N). Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
32 17674319 Contribution of interleukin-6/gp 130 signaling in hepatocytes to the inflammatory response in mice infected with Streptococcus pyogenes. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
33 11278300 Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
34 8054487 Leukaemia inhibitory factor and interleukin 6 are expressed at very low levels in the normal adult mouse and are induced by inflammation. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
35 11781191 Interleukine-6 (IL-6) synthesis and gp130 expression by human pericardium. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
36 15585099 Disturbed secretory capacity for macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta in progressive HIV infection. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
37 10712626 Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
38 18076643 Possible role of the innate immunity in temporal lobe epilepsy. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
39 28402851 IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
40 20660911 Soluble gp130 regulatess interleukin-6 in cerebrospinal fluid after subarachnoid haemorrhage. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
41 3058856 Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
42 28677723 Telomere length is positively associated with the expression of ILâ??6 and MIPâ??1α in bone marrow mesenchymal stem cells of multiple myeloma. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
43 21606248 IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
44 17249568 Transgenic expression of leukemia inhibitory factor inhibits both rod and cone gene expression. Gp130 regulates cone gene expression. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
45 15905624 Human endometrial leukemia inhibitory factor and interleukin-6: control of secretion by transforming growth factor-beta-related members. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
46 23760235 Autocrine CCL3 and CCL4 induced by the oncoprotein LMP1 promote Epstein-Barr virus-triggered B cell proliferation. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
47 27226573 Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
48 9933112 Activation of gp130 signaling in vivo by the IL-6 super-agonist K-7/D-6 accelerates repopulation of lymphoid organs after irradiation. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
49 14527405 Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
50 14755335 Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways. Pubmed 2.879E-8 4.157E-6 3.949E-5 2.162E-4 2 2
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 96 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:IL6ST IL6ST interactions 4.010E-7 1.930E-5 9.931E-5 3.849E-5 3 41
2 int:LIF LIF interactions 4.020E-7 1.930E-5 9.931E-5 3.859E-5 2 3
3 int:CNTFR CNTFR interactions 6.022E-6 1.927E-4 9.918E-4 5.781E-4 2 10
4 int:CCL4 CCL4 interactions 8.829E-6 1.947E-4 1.002E-3 8.476E-4 2 12
5 int:CCL3 CCL3 interactions 1.217E-5 1.947E-4 1.002E-3 1.168E-3 2 14
6 int:IL6 IL6 interactions 1.217E-5 1.947E-4 1.002E-3 1.168E-3 2 14
7 int:ACKR2 ACKR2 interactions 2.044E-5 2.804E-4 1.443E-3 1.963E-3 2 18
8 int:CCR3 CCR3 interactions 2.804E-5 2.961E-4 1.524E-3 2.692E-3 2 21
9 int:LIFR LIFR interactions 3.084E-5 2.961E-4 1.524E-3 2.961E-3 2 22
10 int:IL6R IL6R interactions 3.084E-5 2.961E-4 1.524E-3 2.961E-3 2 22
11 int:CCR1 CCR1 interactions 8.867E-5 7.739E-4 3.983E-3 8.513E-3 2 37
12 int:CCR5 CCR5 interactions 1.316E-4 1.053E-3 5.419E-3 1.263E-2 2 45
13 int:HRH1 HRH1 interactions 7.907E-4 5.839E-3 3.005E-2
7.591E-2
 1 2
14 int:CLCF1 CLCF1 interactions 1.581E-3 1.084E-2
5.579E-2
1.518E-1
 1 4
15 int:CTF1 CTF1 interactions 2.370E-3 1.517E-2
7.808E-2
2.276E-1
 1 6
16 int:CCR8 CCR8 interactions 2.765E-3 1.596E-2
8.216E-2
2.654E-1
 1 7
17 int:NFKBIZ NFKBIZ interactions 3.160E-3 1.596E-2
8.216E-2
3.033E-1
 1 8
18 int:CRLF1 CRLF1 interactions 3.160E-3 1.596E-2
8.216E-2
3.033E-1
 1 8
19 int:CCR4 CCR4 interactions 3.160E-3 1.596E-2
8.216E-2
3.033E-1
 1 8
20 int:PTHLH PTHLH interactions 3.554E-3 1.706E-2
8.780E-2
3.412E-1
 1 9
21 int:CSH2 CSH2 interactions 3.948E-3 1.805E-2
9.289E-2
3.790E-1
 1 10
22 int:SLC30A2 SLC30A2 interactions 4.736E-3 1.977E-2
1.017E-1
4.547E-1
 1 12
23 int:OSMR OSMR interactions 4.736E-3 1.977E-2
1.017E-1
4.547E-1
 1 12
24 int:DMAC2L DMAC2L interactions 5.524E-3 2.209E-2
1.137E-1
5.303E-1
 1 14
25 int:SRGN SRGN interactions 5.917E-3 2.272E-2
1.169E-1
5.680E-1
 1 15
26 int:GLDC GLDC interactions 7.097E-3 2.479E-2
1.276E-1
6.813E-1
 1 18
27 int:OSM OSM interactions 7.097E-3 2.479E-2
1.276E-1
6.813E-1
 1 18
28 int:HIST1H3C HIST1H3C interactions 7.490E-3 2.479E-2
1.276E-1
7.190E-1
 1 19
29 int:CNTF CNTF interactions 7.490E-3 2.479E-2
1.276E-1
7.190E-1
 1 19
30 int:AMZ2 AMZ2 interactions 8.276E-3 2.648E-2
1.363E-1
7.945E-1
 1 21
31 int:KCNIP3 KCNIP3 interactions 9.061E-3 2.806E-2
1.444E-1
8.698E-1
 1 23
32 int:SOST SOST interactions 9.453E-3 2.836E-2
1.460E-1
9.075E-1
 1 24
33 int:IL31RA IL31RA interactions 1.024E-2 2.891E-2
1.488E-1
9.828E-1
 1 26
34 int:LRP4 LRP4 interactions 1.024E-2 2.891E-2
1.488E-1
9.828E-1
 1 26
35 int:CXCL8 CXCL8 interactions 1.063E-2 2.915E-2
1.501E-1
1.000E0
 1 27
36 int:HLA-DPB1 HLA-DPB1 interactions 1.493E-2 3.874E-2
1.994E-1
1.000E0
 1 38
37 int:PIK3CG PIK3CG interactions 1.493E-2 3.874E-2
1.994E-1
1.000E0
 1 38
38 int:DCAF5 DCAF5 interactions 1.649E-2 4.166E-2
2.144E-1
1.000E0
 1 42
39 int:LRP5 LRP5 interactions 1.805E-2 4.443E-2
2.287E-1
1.000E0
 1 46
40 int:PSMG2 PSMG2 interactions 1.922E-2 4.612E-2
2.374E-1
1.000E0
 1 49
41 int:SORL1 SORL1 interactions 2.038E-2 4.617E-2
2.376E-1
1.000E0
 1 52
42 int:PYCARD PYCARD interactions 2.077E-2 4.617E-2
2.376E-1
1.000E0
 1 53
43 int:PSMG3 PSMG3 interactions 2.116E-2 4.617E-2
2.376E-1
1.000E0
 1 54
44 int:LRP6 LRP6 interactions 2.116E-2 4.617E-2
2.376E-1
1.000E0
 1 54
Show 39 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17q12 17q12 1.890E-4 1.134E-3 2.778E-3 1.134E-3 2 105
2 7p21 7p21 1.413E-3 4.239E-3 1.039E-2 8.478E-3 1 7
3 11q13.3 11q13.3 5.038E-3 1.008E-2 2.469E-2 3.023E-2 1 25
4 5q11.2 5q11.2 1.106E-2 1.447E-2 3.544E-2
6.633E-2
 1 55
5 22q12.2 22q12.2 1.206E-2 1.447E-2 3.544E-2
7.233E-2
 1 60
6 17q11.2 17q11.2 2.280E-2 2.280E-2
5.586E-2
1.368E-1
 1 114
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 94 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$COREBINDINGFACTOR Q6 V$COREBINDINGFACTOR Q6 3.623E-6 3.406E-4 1.746E-3 3.406E-4 4 220
2 RACCACAR V$AML Q6 RACCACAR V$AML Q6 1.738E-4 8.168E-3 4.187E-2 1.634E-2 3 205
3 CCANNAGRKGGC UNKNOWN CCANNAGRKGGC UNKNOWN 1.202E-3 3.766E-2
1.930E-1
1.130E-1
 2 89

12: Gene Family [Display Chart] 7 input genes in category / 9 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1264 Interleukin 6 cytokine family genenames.org 1.220E-9 1.098E-8 3.106E-8 1.098E-8 3 7
2 542 Endogenous ligands genenames.org 7.349E-5 3.307E-4 9.356E-4 6.615E-4 3 237
3 483 Chemokine ligands|Endogenous ligands genenames.org 1.246E-4 3.739E-4 1.058E-3 1.122E-3 2 45
4 1246 DAN family genenames.org 2.691E-3 6.054E-3 1.713E-2 2.421E-2 1 7
5 598 Interferons genenames.org 1.225E-2 2.112E-2
5.976E-2
1.102E-1
 1 32
6 602 Fibronectin type III domain containing|Interleukin receptors genenames.org 1.605E-2 2.112E-2
5.976E-2
1.445E-1
 1 42
7 601 Interleukins|PDZ domain containing genenames.org 1.643E-2 2.112E-2
5.976E-2
1.479E-1
 1 43
Show 2 more annotations

13: Coexpression [Display Chart] 7 input genes in category / 1342 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19818417-Table2 Human Lung not cancer Kent10 40genes GeneSigDB 1.721E-10 1.919E-7 1.493E-6 2.310E-7 4 36
2 20460173-ImmPortCytokines Human Immune Kong10 456genes ImmPort Cytokines GeneSigDB 2.860E-10 1.919E-7 1.493E-6 3.839E-7 6 433
3 M5890 Genes regulated by NF-kB in response to TNF [GeneID=7124]. MSigDB H: Hallmark Gene Sets (v6.0) 9.506E-10 4.253E-7 3.308E-6 1.276E-6 5 200
4 18707017-Table1 Human Leukemia Kalwitz08 35genes GeneSigDB 8.379E-8 2.260E-5 1.759E-4 1.124E-4 3 32
5 18403781-Table2 Mouse Lung not cancer Pulichino08 39genes GeneSigDB 9.216E-8 2.260E-5 1.759E-4 1.237E-4 3 33
6 16585964-SuppTable1 Mouse Lung not cancer Thimmulappa06 38genes GeneSigDB 1.011E-7 2.260E-5 1.759E-4 1.356E-4 3 34
7 M9830 Genes down-regulated in at day 0 B cell IRF4-KO versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4high. MSigDB C7: Immunologic Signatures (v6.0) 1.858E-7 2.998E-5 2.332E-4 2.494E-4 4 200
8 M3913 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 1.858E-7 2.998E-5 2.332E-4 2.494E-4 4 200
9 12791645-Table2 Human BoneMarrow Croonquist03 50genes StromaIL6 GeneSigDB 2.234E-7 2.998E-5 2.332E-4 2.998E-4 3 44
10 15482854-Table2 Human Immune Sillanp04 48genes GeneSigDB 2.234E-7 2.998E-5 2.332E-4 2.998E-4 3 44
11 16479545-Table2 Mouse Lung not cancer Kahnert06 70genes GeneSigDB 3.303E-7 4.030E-5 3.135E-4 4.433E-4 3 50
12 16423051-Table3 Human Leukemia Larsson06 54genes GeneSigDB 4.178E-7 4.673E-5 3.635E-4 5.607E-4 3 54
13 M5929 Genes up-regulated in ANBL-6 cell line (multiple myeloma, MM) co-cultured with bone marrow stromal cells compared to those grown in the presence of IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.760E-7 5.946E-5 4.626E-4 7.730E-4 3 60
14 M17033 Maturation of monocyte-derived dendritic cells (DC) in response to inflammatory stimuli: genes up-regulated only at 8 hr after the stimulation (cluster A). MSigDB C2: CGP Curated Gene Sets (v6.0) 8.056E-7 7.722E-5 6.008E-4 1.081E-3 3 67
15 19454749-Table1 Human StemCell Fang09 79genes GeneSigDB 1.134E-6 1.015E-4 7.895E-4 1.522E-3 3 75
16 20220088-SuppTable2a Human Immune Allen10 106genes GeneSigDB 2.960E-6 2.483E-4 1.932E-3 3.973E-3 3 103
17 16479545-SuppTable1 Mouse Lung not cancer Kahnert06 163genes GeneSigDB 4.459E-6 3.520E-4 2.738E-3 5.984E-3 3 118
18 M2568 Genes up-regulated in lung tissue upon LPS aspiration with mechanical ventilation (MV) compared to control (PBS aspiration without MV). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.696E-6 4.246E-4 3.303E-3 7.643E-3 3 128
19 M18685 Genes up-regulated in macrophage by live P.gingivalis. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.297E-6 4.448E-4 3.460E-3 8.451E-3 4 484
20 20138012-Table1 Mouse StemCell Erez10 15genes GeneSigDB 7.128E-6 4.783E-4 3.721E-3 9.565E-3 2 14
21 M2502 Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were blocked partially by p38 inhibitor LY479754. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.113E-5 6.936E-4 5.396E-3 1.494E-2 3 160
22 18358739-Table1a Human LungNotCaner Kent08 23genes GeneSigDB 1.338E-5 6.936E-4 5.396E-3 1.796E-2 2 19
23 M7624 Genes up-regulated in memory CD8 T cells: 2' versus 4'. MSigDB C7: Immunologic Signatures (v6.0) 1.481E-5 6.936E-4 5.396E-3 1.987E-2 3 176
24 11114790-Table1 Rat Lung not cancer Nadadur00 30genes GeneSigDB 1.487E-5 6.936E-4 5.396E-3 1.995E-2 2 20
25 18519693-Table1 Human StemCell Mishra08 289genes GeneSigDB 1.637E-5 6.936E-4 5.396E-3 2.197E-2 3 182
26 15173083-Table2 Human Brain Levy04 32genes GeneSigDB 1.643E-5 6.936E-4 5.396E-3 2.205E-2 2 21
27 12946996-Table4 Human Lymphoma Kaminski03 28genes GeneSigDB 1.643E-5 6.936E-4 5.396E-3 2.205E-2 2 21
28 M377 Genes up-regulated in dendritic cells: wildtype versus NFKB2 [GeneID=4791]. MSigDB C7: Immunologic Signatures (v6.0) 1.692E-5 6.936E-4 5.396E-3 2.270E-2 3 184
29 15735688-Table1 Human Leukemia Fung05 23genes GeneSigDB 1.807E-5 6.936E-4 5.396E-3 2.425E-2 2 22
30 M5849 Genes down-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] versus monocytes treated with anti-TREM1 [GeneID=54210] and 5000 ng/ml LPS (TLR4 agonist). MSigDB C7: Immunologic Signatures (v6.0) 2.075E-5 6.936E-4 5.396E-3 2.785E-2 3 197
31 M4728 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 8 h. MSigDB C7: Immunologic Signatures (v6.0) 2.107E-5 6.936E-4 5.396E-3 2.827E-2 3 198
32 M5858 Genes up-regulated in comparison of monocytes treated with 5000 ng/ml LPS (TLR4 agonist) versus monocytes treated with control IgG. MSigDB C7: Immunologic Signatures (v6.0) 2.107E-5 6.936E-4 5.396E-3 2.827E-2 3 198
33 M5867 Genes up-regulated in comparison of monocytes treated with 1 ng/ml LPS (TLR4 agonist) versus monocytes treated with control IgG. MSigDB C7: Immunologic Signatures (v6.0) 2.107E-5 6.936E-4 5.396E-3 2.827E-2 3 198
34 M4692 Genes down-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with R848 for 2 h. MSigDB C7: Immunologic Signatures (v6.0) 2.139E-5 6.936E-4 5.396E-3 2.870E-2 3 199
35 M5760 Genes down-regulated in comparison of untreated macrophages versus those treated with IL1. MSigDB C7: Immunologic Signatures (v6.0) 2.139E-5 6.936E-4 5.396E-3 2.870E-2 3 199
36 M17340 NF-kB-driven pro-inflammatory genes that are negatively regulated by glucocorticoids. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.159E-5 6.936E-4 5.396E-3 2.897E-2 2 24
37 M5845 Genes down-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] versus monocytes treated with 5000 ng/ml LPS (TLR4 agonist). MSigDB C7: Immunologic Signatures (v6.0) 2.171E-5 6.936E-4 5.396E-3 2.913E-2 3 200
38 M5847 Genes down-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] versus monocytes treated with 1 ng/ml LPS (TLR4 agonist). MSigDB C7: Immunologic Signatures (v6.0) 2.171E-5 6.936E-4 5.396E-3 2.913E-2 3 200
39 M5950 Genes up-regulated during transplant rejection. MSigDB H: Hallmark Gene Sets (v6.0) 2.171E-5 6.936E-4 5.396E-3 2.913E-2 3 200
40 M10031 Genes up-regulated in NK cells versus B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.171E-5 6.936E-4 5.396E-3 2.913E-2 3 200
41 M7670 Genes up-regulated in the in vitro follicular dendritic cells from peripheral lymph nodes: unstimulated versus Pam2CSK4 (96h). MSigDB C7: Immunologic Signatures (v6.0) 2.171E-5 6.936E-4 5.396E-3 2.913E-2 3 200
42 M10027 Genes down-regulated in NK cells versus ITGAM+ [GeneID=3684] dendritic cells. MSigDB C7: Immunologic Signatures (v6.0) 2.171E-5 6.936E-4 5.396E-3 2.913E-2 3 200
43 15501955-Table1 Human Breast Bieche04 29genes invasive GeneSigDB 2.346E-5 7.322E-4 5.696E-3 3.148E-2 2 25
44 19795415-Table1 Mouse Lung Beisiegel09 262genes GeneSigDB 2.406E-5 7.338E-4 5.709E-3 3.229E-2 3 207
45 17823238-TableS4a Mouse EmbryonicStemCell Soh07 224genes A GeneSigDB 2.584E-5 7.705E-4 5.994E-3 3.467E-2 3 212
46 17823238-TableS4b Human EmbryonicStemCell Soh07 224genes B GeneSigDB 2.886E-5 8.419E-4 6.550E-3 3.873E-2 3 220
47 M2256 Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.169E-5 8.872E-4 6.902E-3 4.252E-2 3 227
48 15815727-Table3 Human Leukemia Janssen05 33genes GeneSigDB 3.173E-5 8.872E-4 6.902E-3 4.258E-2 2 29
49 M1989 Selected genes with immunologic function which were reciprocally changed in evasion and tolerogenic tumor models. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.399E-5 9.124E-4 7.098E-3 4.562E-2 2 30
50 M8344 Top 30 increased eosinophil specific transcripts. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.399E-5 9.124E-4 7.098E-3 4.562E-2 2 30
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 795 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Sample Type by Project: Shred 1/TCGA-Kidney/Renal Cell Carcinoma/Kidney Chromophobe/6/3 Sample Type by Project: Shred 1/TCGA-Kidney/Renal Cell Carcinoma/Kidney Chromophobe/6/3 TCGA-Kidney 1.714E-7 8.587E-5 6.231E-4 1.362E-4 4 185
2 Immune cells (IMM)/Immune cells (IMM) h Immune cells (IMM)/Immune cells (IMM) h 2.160E-7 8.587E-5 6.231E-4 1.717E-4 4 196
3 GSM854269 100 Myeloid Cells, DC.103-11b+24+.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24+, Lung, avg-2 Immgen.org, GSE15907 1.350E-6 2.417E-4 1.754E-3 1.073E-3 3 75
4 GSM605820 100 Myeloid Cells, DC.103+11b-.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 1.520E-6 2.417E-4 1.754E-3 1.209E-3 3 78
5 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/late fetal/IMM h Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/late fetal/IMM h Fetal, Development 1.520E-6 2.417E-4 1.754E-3 1.209E-3 3 78
6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour RCC U U/Kidney Tumour RCC U10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour RCC U U/Kidney Tumour RCC U10 Adult, Development, and Cancer types 3.962E-6 5.249E-4 3.809E-3 3.150E-3 2 10
7 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Renal interstitium (RI)/late fetal Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Renal interstitium (RI)/late fetal Fetal, Development 4.841E-6 5.498E-4 3.990E-3 3.849E-3 2 11
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Tumour RCC Nephrogenesis/Kidney Tumour RCC F10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Tumour RCC Nephrogenesis/Kidney Tumour RCC F10 Adult, Development, and Cancer types 8.007E-6 7.957E-4 5.773E-3 6.365E-3 2 14
9 geo heart 1000 K4 geo heart top-relative-expression-ranked 1000 k-means-cluster#4 PCBC 1.069E-5 9.445E-4 6.853E-3 8.500E-3 3 149
10 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/2/3 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/2/3 TCGA-Stomach 1.644E-5 1.207E-3 8.759E-3 1.307E-2 3 172
11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney Tumour PapRCC EN-U/Kidney Tumour PapRCC EN10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney Tumour PapRCC EN-U/Kidney Tumour PapRCC EN10 Adult, Development, and Cancer types 1.670E-5 1.207E-3 8.759E-3 1.328E-2 2 20
12 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hMgl Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hMgl Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 2.012E-5 1.230E-3 8.926E-3 1.599E-2 3 184
13 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hMgl Top 200 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hMgl Top 200 GSE76381_EmbryoMoleculeCountsPMLog2 2.012E-5 1.230E-3 8.926E-3 1.599E-2 3 184
14 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/5/1 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/5/1 TCGA-Colorectal 2.249E-5 1.277E-3 9.268E-3 1.788E-2 3 191
15 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hMgl Top 40 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hMgl Top 40 GSE76381_EmbryoMoleculeCountsPMLog2 4.632E-5 2.302E-3 1.670E-2 3.683E-2 2 33
16 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hMgl Overall Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hMgl Overall Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 4.632E-5 2.302E-3 1.670E-2 3.683E-2 2 33
17 GSM605820 500 Myeloid Cells, DC.103+11b-.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 1.794E-4 7.591E-3
5.508E-2
1.426E-1
 3 384
18 GSM538297 500 NK cells, NK.DAP12-.Sp, NK1.1+ CD3-, Spleen, avg-3 Immgen.org, GSE15907 2.054E-4 7.591E-3
5.508E-2
1.633E-1
 3 402
19 GSM854269 500 Myeloid Cells, DC.103-11b+24+.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24+, Lung, avg-2 Immgen.org, GSE15907 2.084E-4 7.591E-3
5.508E-2
1.657E-1
 3 404
20 GSM605823 500 Myeloid Cells, DC.103-11b+.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 2.161E-4 7.591E-3
5.508E-2
1.718E-1
 3 409
21 GSM605817 500 NK cells, NK.49H-.Sp, NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 2.224E-4 7.591E-3
5.508E-2
1.768E-1
 3 413
22 GSM538303 500 NK cells, NK.H+.MCMV7.Sp, NK1.1+ TCRb- Ly49H+, Spleen, avg-3 Immgen.org, GSE15907 2.240E-4 7.591E-3
5.508E-2
1.781E-1
 3 414
23 GSM854271 500 Myeloid Cells, DC.103-11b+24-.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24-, Lung, avg-2 Immgen.org, GSE15907 2.240E-4 7.591E-3
5.508E-2
1.781E-1
 3 414
24 GSM538309 100 NK cells, NK.MCMV1.Sp, CD3-,NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 2.291E-4 7.591E-3
5.508E-2
1.822E-1
 2 73
25 GSM538300 100 NK cells, NK.H+.MCMV1.Sp, NK1.1+ TCRb- Ly49H+, Spleen, avg-3 Immgen.org, GSE15907 2.419E-4 7.692E-3
5.582E-2
1.923E-1
 2 75
26 GSM605823 100 Myeloid Cells, DC.103-11b+.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 2.822E-4 8.011E-3
5.813E-2
2.243E-1
 2 81
27 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal-Medulla Wilms PT-U/Kidney Normal-Medulla Wilms PT10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal-Medulla Wilms PT-U/Kidney Normal-Medulla Wilms PT10 Adult, Development, and Cancer types 2.822E-4 8.011E-3
5.813E-2
2.243E-1
 2 81
28 GSM854271 100 Myeloid Cells, DC.103-11b+24-.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24-, Lung, avg-2 Immgen.org, GSE15907 2.822E-4 8.011E-3
5.813E-2
2.243E-1
 2 81
29 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/late fetal Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/late fetal Fetal, Development 2.963E-4 8.122E-3
5.893E-2
2.355E-1
 2 83
30 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal RCC Junk/Kidney Normal RCC IF0 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal RCC Junk/Kidney Normal RCC IF0 Adult, Development, and Cancer types 3.207E-4 8.498E-3
6.166E-2
2.549E-1
 1 1
31 Arv EB-LF 500 K3 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 500 k-means-cluster#3 PCBC 3.639E-4 9.333E-3
6.772E-2
2.893E-1
 2 92
32 Arv EB-LF 500 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 500 PCBC 3.881E-4 9.641E-3
6.996E-2
3.085E-1
 3 499
33 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell 1/Kidney Tumour RCC NK cell 1/Kidney Tumour RCC IT10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell 1/Kidney Tumour RCC NK cell 1/Kidney Tumour RCC IT10 Adult, Development, and Cancer types 4.385E-4 1.056E-2
7.664E-2
3.486E-1
 2 101
34 Sample Type by Project: Shred 1/TCGA-Cervix/Cervical Carcinoma/Keratinizing Cervical Squamous Cell Carcinoma/4/4 Sample Type by Project: Shred 1/TCGA-Cervix/Cervical Carcinoma/Keratinizing Cervical Squamous Cell Carcinoma/4/4 TCGA-Cervix 5.679E-4 1.328E-2
9.635E-2
4.515E-1
 2 115
35 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type C/4/1 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type C/4/1 TCGA-Thymus 6.079E-4 1.381E-2
1.002E-1
4.833E-1
 2 119
36 Sample Type by Project: Shred 1/TCGA-Adrenal Cortex/Adrenocortical carcinoma/Usual Type/3/0 Sample Type by Project: Shred 1/TCGA-Adrenal Cortex/Adrenocortical carcinoma/Usual Type/3/0 TCGA-Adrenal Cortex 6.919E-4 1.528E-2
1.109E-1
5.501E-1
 2 127
37 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Embryonal Carcinoma, Yolk Sac Tumor/3/1 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Embryonal Carcinoma, Yolk Sac Tumor/3/1 TCGA-Testes 7.248E-4 1.557E-2
1.130E-1
5.762E-1
 2 130
38 Sample Type by Project: Shred 1/TCGA-Bladder/Urothelial Carcinoma/Non-Papillary Muscle Invasive Urothelial Carcinoma/5/0 Sample Type by Project: Shred 1/TCGA-Bladder/Urothelial Carcinoma/Non-Papillary Muscle Invasive Urothelial Carcinoma/5/0 TCGA-Bladder 8.279E-4 1.732E-2
1.257E-1
6.582E-1
 2 139
39 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Colon Adenocarcinoma/4/1 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Colon Adenocarcinoma/4/1 TCGA-Colorectal 9.003E-4 1.835E-2
1.332E-1
7.158E-1
 2 145
40 gallbladder gallbladder Human Protein Atlas 9.377E-4 1.864E-2
1.352E-1
7.455E-1
 2 148
41 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell/Ureter Normal RCC NK8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell/Ureter Normal RCC NK8 Adult, Development, and Cancer types 9.886E-4 1.917E-2
1.391E-1
7.860E-1
 2 152
42 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Oligoastrocytoma/3/3 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Oligoastrocytoma/3/3 TCGA-Brain 1.163E-3 1.980E-2
1.436E-1
9.248E-1
 2 165
43 Sample Type by Project: Shred 1/TCGA-Peripheral Nervous System/Paraganglioma/Paraganglioma/3/0 Sample Type by Project: Shred 1/TCGA-Peripheral Nervous System/Paraganglioma/Paraganglioma/3/0 TCGA-Peripheral Nervous System 1.206E-3 1.980E-2
1.436E-1
9.584E-1
 2 168
44 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Tumour RCC EN-A/Kidney Tumour RCC EN2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Tumour RCC EN-A/Kidney Tumour RCC EN2 Adult, Development, and Cancer types 1.282E-3 1.980E-2
1.436E-1
1.000E0
 1 4
45 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma/Epitheliod/3/1 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma/Epitheliod/3/1 TCGA-Mesothelium 1.307E-3 1.980E-2
1.436E-1
1.000E0
 2 175
46 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-G/Kidney NephrogenicRest Wilms EN-G Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-G/Kidney NephrogenicRest Wilms EN-G Adult, Development, and Cancer types 1.382E-3 1.980E-2
1.436E-1
1.000E0
 2 180
47 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney NephrogenicRest Wilms R U/Kidney NephrogenicRest Wilms R3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney NephrogenicRest Wilms R U/Kidney NephrogenicRest Wilms R3 Adult, Development, and Cancer types 1.459E-3 1.980E-2
1.436E-1
1.000E0
 2 185
48 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney NephrogenicRest Wilms IF-U/Kidney NephrogenicRest Wilms IF12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney NephrogenicRest Wilms IF-U/Kidney NephrogenicRest Wilms IF12 Adult, Development, and Cancer types 1.490E-3 1.980E-2
1.436E-1
1.000E0
 2 187
49 10X Human 8K PBMC NK cells (GZMB, SPON2, GNLY) Overall Top 200 Genes 10X Human 8K PBMC NK cells (GZMB, SPON2, GNLY) Overall Top 200 Genes 1.538E-3 1.980E-2
1.436E-1
1.000E0
 2 190
50 Endothelial cells (ED)/Endothelial cells (ED) a Endothelial cells (ED)/Endothelial cells (ED) a 1.554E-3 1.980E-2
1.436E-1
1.000E0
 2 191
Show 45 more annotations

15: Computational [Display Chart] 6 input genes in category / 63 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M15983 MODULE 46 Genes in the cancer module 46. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.281E-7 1.436E-5 6.790E-5 3.327E-5 5 394
2 M12401 MODULE 75 Immune response. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.554E-7 1.436E-5 6.790E-5 3.499E-5 5 398
3 M10197 MODULE 92 Secreted signaling molecules. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.838E-7 1.436E-5 6.790E-5 4.308E-5 4 149
4 M18720 MODULE 521 T-cell proliferation genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.859E-4 2.929E-3 1.385E-2 1.171E-2 2 36
5 M7015 MODULE 263 Chemotaxis (chemokines). MSigDb: C4 - CM: Cancer Modules (v6.0) 2.915E-4 3.673E-3 1.737E-2 1.836E-2 2 45
6 M6482 MODULE 108 Genes in the cancer module 108. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.521E-4 4.747E-3 2.245E-2 2.848E-2 2 56
7 M7888 MODULE 433 Cytokines and GFs. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.365E-4 4.829E-3 2.283E-2 3.380E-2 2 61
8 M17322 MODULE 76 Inflammatory response. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.449E-4 7.441E-3 3.518E-2
5.953E-2
 2 81
9 M8921 MODULE 53 Cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.191E-3 8.063E-3 3.813E-2
7.502E-2
 3 405
10 M10511 MODULE 169 Immune response. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.352E-3 8.063E-3 3.813E-2
8.518E-2
 2 97
11 M18183 MODULE 121 Genes in the cancer module 121. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.408E-3 8.063E-3 3.813E-2
8.870E-2
 2 99
12 M18856 MODULE 456 B lymphoma expression clusters. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.830E-3 9.606E-3 4.542E-2
1.153E-1
 2 113
13 M1653 MODULE 223 Immune (defense) response. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.872E-3 1.392E-2
6.582E-2
1.810E-1
 2 142
14 M10977 MODULE 563 Genes in the cancer module 563. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.936E-3 4.021E-2
1.901E-1
5.629E-1
 1 15
15 M4637 MODULE 262 Cell ion homeostasis / chemokines. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.131E-2 4.190E-2
1.981E-1
7.124E-1
 1 19
16 M15504 MODULE 400 Genes in the cancer module 400. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.131E-2 4.190E-2
1.981E-1
7.124E-1
 1 19
17 M17192 MODULE 191 Genes in the cancer module 191. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.131E-2 4.190E-2
1.981E-1
7.124E-1
 1 19
Show 12 more annotations

16: MicroRNA [Display Chart] 7 input genes in category / 274 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-223-3p:Functional MTI Functional MTI miRTarbase 1.111E-10 3.043E-8 1.885E-7 3.043E-8 4 98
2 hsa-miR-223-3p:TargetScan hsa-miR-223-3p TargetScan 3.148E-4 1.736E-2
1.075E-1
8.625E-2
 2 282
3 hsa-miR-194-5p:TargetScan hsa-miR-194-5p TargetScan 4.303E-4 1.736E-2
1.075E-1
1.179E-1
 2 330
4 hsa-miR-149-5p:TargetScan hsa-miR-149-5p TargetScan 5.144E-4 1.736E-2
1.075E-1
1.409E-1
 2 361
5 hsa-miR-142-3p:Functional MTI Functional MTI miRTarbase 5.966E-4 1.736E-2
1.075E-1
1.635E-1
 2 389
6 hsa-miR-653-5p:TargetScan hsa-miR-653-5p TargetScan 7.755E-4 1.736E-2
1.075E-1
2.125E-1
 2 444
7 hsa-miR-494-3p:TargetScan hsa-miR-494-3p TargetScan 7.824E-4 1.736E-2
1.075E-1
2.144E-1
 2 446
8 hsa-miR-520f:PITA hsa-miR-520f:PITA TOP PITA 8.034E-4 1.736E-2
1.075E-1
2.201E-1
 2 452
9 hsa-miR-26a-5p:Functional MTI Functional MTI miRTarbase 8.211E-4 1.736E-2
1.075E-1
2.250E-1
 2 457
10 hsa-miR-654-5p:mirSVR highEffct hsa-miR-654-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.717E-4 1.736E-2
1.075E-1
2.388E-1
 2 471
11 hsa-miR-140-3p.1:TargetScan hsa-miR-140-3p.1 TargetScan 9.050E-4 1.736E-2
1.075E-1
2.480E-1
 2 480
12 hsa-miR-541:mirSVR highEffct hsa-miR-541:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.125E-4 1.736E-2
1.075E-1
2.500E-1
 2 482
13 hsa-miR-520f-3p:TargetScan hsa-miR-520f-3p TargetScan 9.503E-4 1.736E-2
1.075E-1
2.604E-1
 2 492
14 hsa-miR-302c-3p.2:TargetScan hsa-miR-302c-3p.2 TargetScan 9.503E-4 1.736E-2
1.075E-1
2.604E-1
 2 492
15 hsa-miR-769-3p:mirSVR highEffct hsa-miR-769-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.503E-4 1.736E-2
1.075E-1
2.604E-1
 2 492
16 hsa-miR-4661-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.936E-3 3.316E-2
2.053E-1
5.306E-1
 1 20
17 hsa-miR-451a:Functional MTI Functional MTI miRTarbase 3.000E-3 3.336E-2
2.066E-1
8.220E-1
 1 31
18 hsa-miR-181c-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.097E-3 3.336E-2
2.066E-1
8.485E-1
 1 32
19 hsa-miR-574-3p:PITA hsa-miR-574-3p:PITA TOP PITA 3.097E-3 3.336E-2
2.066E-1
8.485E-1
 1 32
20 hsa-miR-4766-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.676E-3 3.336E-2
2.066E-1
1.000E0
 1 38
21 hsa-miR-624-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.676E-3 3.336E-2
2.066E-1
1.000E0
 1 38
22 GGCAGAC,MIR-346:MSigDB GGCAGAC,MIR-346:MSigDB MSigDB 3.773E-3 3.336E-2
2.066E-1
1.000E0
 1 39
23 hsa-miR-3655:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.063E-3 3.336E-2
2.066E-1
1.000E0
 1 42
24 hsa-miR-676-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.932E-3 3.336E-2
2.066E-1
1.000E0
 1 51
25 hsa-miR-3137:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.317E-3 3.336E-2
2.066E-1
1.000E0
 1 55
26 hsa-miR-4473:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.414E-3 3.336E-2
2.066E-1
1.000E0
 1 56
27 hsa-miR-4454:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.607E-3 3.336E-2
2.066E-1
1.000E0
 1 58
28 hsa-miR-488-5p:Functional MTI Functional MTI miRTarbase 5.703E-3 3.336E-2
2.066E-1
1.000E0
 1 59
29 hsa-miR-3164:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 3.336E-2
2.066E-1
1.000E0
 1 60
30 hsa-miR-2355-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 3.336E-2
2.066E-1
1.000E0
 1 60
31 hsa-miR-892a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 3.336E-2
2.066E-1
1.000E0
 1 60
32 hsa-miR-4501:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 3.336E-2
2.066E-1
1.000E0
 1 61
33 hsa-miR-6820-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 3.336E-2
2.066E-1
1.000E0
 1 61
34 hsa-miR-190b:Functional MTI Functional MTI miRTarbase 5.992E-3 3.336E-2
2.066E-1
1.000E0
 1 62
35 hsa-miR-4708-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.185E-3 3.336E-2
2.066E-1
1.000E0
 1 64
36 hsa-miR-190a-5p:Non-Functional MTI Non-Functional MTI miRTarbase 6.185E-3 3.336E-2
2.066E-1
1.000E0
 1 64
37 hsa-miR-4804-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.185E-3 3.336E-2
2.066E-1
1.000E0
 1 64
38 hsa-miR-3908:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.282E-3 3.336E-2
2.066E-1
1.000E0
 1 65
39 hsa-miR-4782-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.571E-3 3.336E-2
2.066E-1
1.000E0
 1 68
40 hsa-miR-6733-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.571E-3 3.336E-2
2.066E-1
1.000E0
 1 68
41 hsa-miR-5706:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.571E-3 3.336E-2
2.066E-1
1.000E0
 1 68
42 hsa-miR-7852-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.763E-3 3.336E-2
2.066E-1
1.000E0
 1 70
43 hsa-miR-3607-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.956E-3 3.336E-2
2.066E-1
1.000E0
 1 72
44 hsa-miR-5100:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.956E-3 3.336E-2
2.066E-1
1.000E0
 1 72
45 hsa-miR-3922-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.052E-3 3.336E-2
2.066E-1
1.000E0
 1 73
46 hsa-miR-4720-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.245E-3 3.336E-2
2.066E-1
1.000E0
 1 75
47 hsa-miR-3177-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.245E-3 3.336E-2
2.066E-1
1.000E0
 1 75
48 hsa-miR-453:PITA hsa-miR-453:PITA TOP PITA 7.245E-3 3.336E-2
2.066E-1
1.000E0
 1 75
49 hsa-miR-4778-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.341E-3 3.336E-2
2.066E-1
1.000E0
 1 76
50 CAGGGTC,MIR-504:MSigDB CAGGGTC,MIR-504:MSigDB MSigDB 7.534E-3 3.336E-2
2.066E-1
1.000E0
 1 78
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 4637 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C445068 methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate CTD 5.481E-10 1.372E-6 1.237E-5 2.542E-6 4 47
2 ctd:C030107 enterotoxin F, Staphylococcal CTD 6.166E-10 1.372E-6 1.237E-5 2.859E-6 3 7
3 ctd:C000488 cladosporin CTD 8.993E-10 1.372E-6 1.237E-5 4.170E-6 4 53
4 ctd:C490266 neoechinulin A CTD 1.397E-9 1.372E-6 1.237E-5 6.477E-6 4 59
5 ctd:C119092 tigecycline CTD 1.479E-9 1.372E-6 1.237E-5 6.860E-6 3 9
6 ctd:D009183 Mycotoxins CTD 2.497E-9 1.924E-6 1.736E-5 1.158E-5 4 68
7 ctd:C490483 icilin CTD 2.905E-9 1.924E-6 1.736E-5 1.347E-5 3 11
8 ctd:C402696 TMC 120A CTD 3.724E-9 2.025E-6 1.827E-5 1.727E-5 4 75
9 ctd:C046488 trimethyltin CTD 3.931E-9 2.025E-6 1.827E-5 1.823E-5 4 76
10 ctd:D006388 Hemagglutinins CTD 1.196E-8 5.547E-6 5.003E-5 5.547E-5 3 17
11 CID003081257 Peptide 78 Stitch 1.460E-8 5.645E-6 5.091E-5 6.770E-5 4 105
12 ctd:C038459 curdlan CTD 1.698E-8 5.645E-6 5.091E-5 7.876E-5 4 109
13 ctd:D019438 Ritonavir CTD 1.698E-8 5.645E-6 5.091E-5 7.876E-5 4 109
14 ctd:C027118 didecyldimethylammonium CTD 1.704E-8 5.645E-6 5.091E-5 7.903E-5 3 19
15 ctd:C043055 gallium arsenide CTD 3.113E-8 9.624E-6 8.680E-5 1.444E-4 3 23
16 ctd:D004731 Endotoxins CTD 5.139E-8 1.402E-5 1.264E-4 2.383E-4 3 27
17 ctd:D000534 Alum Compounds CTD 5.139E-8 1.402E-5 1.264E-4 2.383E-4 3 27
18 ctd:D017632 Asbestos, Serpentine CTD 6.168E-8 1.589E-5 1.433E-4 2.860E-4 5 454
19 ctd:D000276 Adjuvants, Immunologic CTD 7.130E-8 1.740E-5 1.570E-4 3.306E-4 3 30
20 ctd:C000593591 coagulin-L CTD 1.050E-7 2.319E-5 2.092E-4 4.871E-4 3 34
21 ctd:D000536 Aluminum Hydroxide CTD 1.050E-7 2.319E-5 2.092E-4 4.871E-4 3 34
22 CID000512282 BX471 Stitch 1.253E-7 2.641E-5 2.382E-4 5.810E-4 3 36
23 ctd:C440499 lipopolysaccharide, Escherichia coli O111 B4 CTD 1.626E-7 3.279E-5 2.957E-4 7.541E-4 4 191
24 ctd:D014414 Tungsten CTD 2.164E-7 4.180E-5 3.770E-4 1.003E-3 3 43
25 ctd:C111427 silicon titanium dioxide CTD 2.415E-7 4.324E-5 3.899E-4 1.120E-3 2 3
26 CID000465968 KRH-1636 Stitch 2.487E-7 4.324E-5 3.899E-4 1.153E-3 3 45
27 ctd:C020972 pyrrolidine dithiocarbamic acid CTD 2.517E-7 4.324E-5 3.899E-4 1.167E-3 4 213
28 CID005745214 CNI-1493 Stitch 2.841E-7 4.706E-5 4.244E-4 1.318E-3 3 47
29 ctd:C015380 neoechinulin CTD 3.228E-7 4.989E-5 4.500E-4 1.497E-3 3 49
30 ctd:C020711 beryllium sulfate CTD 3.228E-7 4.989E-5 4.500E-4 1.497E-3 3 49
31 ctd:D004391 Dust CTD 3.926E-7 5.764E-5 5.198E-4 1.820E-3 4 238
32 ctd:C004532 quinone CTD 4.102E-7 5.764E-5 5.198E-4 1.902E-3 3 53
33 ctd:C031818 enterotoxin B, staphylococcal CTD 4.102E-7 5.764E-5 5.198E-4 1.902E-3 3 53
34 ctd:C003001 7-ketocholesterol CTD 4.343E-7 5.922E-5 5.342E-4 2.014E-3 3 54
35 ctd:D003436 Croton Oil CTD 4.592E-7 6.084E-5 5.488E-4 2.130E-3 3 55
36 CID000097711 g130 Stitch 5.986E-7 7.711E-5 6.954E-4 2.776E-3 3 60
37 ctd:C076996 27-hydroxycholesterol CTD 6.614E-7 8.289E-5 7.476E-4 3.067E-3 3 62
38 CID000448864 hexadecyl octanoate Stitch 6.944E-7 8.474E-5 7.642E-4 3.220E-3 3 63
39 CID000005245 risedronate Stitch 7.999E-7 9.101E-5 8.209E-4 3.709E-3 3 66
40 CID000062375 U224 Stitch 8.047E-7 9.101E-5 8.209E-4 3.732E-3 2 5
41 ctd:C517734 roflumilast N-oxide CTD 8.047E-7 9.101E-5 8.209E-4 3.732E-3 2 5
42 CID000000299 chlordecone Stitch 8.373E-7 9.244E-5 8.337E-4 3.882E-3 3 67
43 ctd:D015112 4-Nitroquinoline-1-oxide CTD 9.984E-7 1.077E-4 9.710E-4 4.630E-3 3 71
44 CID000335434 NSC344682 Stitch 1.042E-6 1.098E-4 9.901E-4 4.830E-3 3 72
45 CID011703683 CHEMBL372561 Stitch 1.086E-6 1.119E-4 1.009E-3 5.037E-3 3 73
46 ctd:D062610 Fungal Polysaccharides CTD 1.132E-6 1.141E-4 1.029E-3 5.249E-3 3 74
47 ctd:C483161 beta-hydroxy simvastatin acid CTD 1.328E-6 1.310E-4 1.181E-3 6.156E-3 3 78
48 ctd:D019819 Budesonide CTD 1.433E-6 1.357E-4 1.223E-3 6.647E-3 3 80
49 CID000448157 AC1L9LNU Stitch 1.433E-6 1.357E-4 1.223E-3 6.647E-3 3 80
50 CID000016827 MP-B Stitch 1.662E-6 1.424E-4 1.285E-3 7.705E-3 3 84
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 1255 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0020517 Hypersensitivity DisGeNET Curated 7.195E-9 9.030E-6 6.964E-5 9.030E-6 4 63
2 C0273115 Lung Injury DisGeNET Curated 5.609E-8 3.520E-5 2.715E-4 7.039E-5 3 20
3 C0014070 Encephalomyelitis DisGeNET BeFree 8.870E-8 3.710E-5 2.862E-4 1.113E-4 5 347
4 C0000833 Abscess DisGeNET BeFree 3.211E-7 1.008E-4 7.771E-4 4.030E-4 3 35
5 C0011206 Delirium DisGeNET Curated 6.487E-7 1.555E-4 1.199E-3 8.142E-4 3 44
6 C0153252 Systemic candidiasis DisGeNET BeFree 7.433E-7 1.555E-4 1.199E-3 9.328E-4 3 46
7 C0033375 Prolactinoma DisGeNET Curated 4.308E-6 7.216E-4 5.565E-3 5.406E-3 3 82
8 C0035126 Reperfusion Injury DisGeNET Curated 4.801E-6 7.216E-4 5.565E-3 6.026E-3 3 85
9 C0020437 Hypercalcemia DisGeNET Curated 5.332E-6 7.216E-4 5.565E-3 6.691E-3 3 88
10 C0085315 Toxoplasmosis, Cerebral DisGeNET BeFree 5.750E-6 7.216E-4 5.565E-3 7.216E-3 2 9
11 C0021368 Inflammation DisGeNET Curated 1.163E-5 1.324E-3 1.021E-2 1.459E-2 3 114
12 C3826758 AIDS (Disease) DisGeNET BeFree 1.452E-5 1.324E-3 1.021E-2 1.822E-2 2 14
13 C0149911 Humoral hypercalcemia of malignancy (disorder) DisGeNET BeFree 1.452E-5 1.324E-3 1.021E-2 1.822E-2 2 14
14 C0151744 Myocardial Ischemia DisGeNET Curated 1.477E-5 1.324E-3 1.021E-2 1.854E-2 4 421
15 C0023343 Leprosy DisGeNET Curated 1.646E-5 1.377E-3 1.062E-2 2.066E-2 3 128
16 C0017531 Angiolymphoid hyperplasia DisGeNET Curated 1.914E-5 1.490E-3 1.149E-2 2.402E-2 2 16
17 C0007786 Brain Ischemia DisGeNET Curated 2.018E-5 1.490E-3 1.149E-2 2.533E-2 3 137
18 C1518693 Ovarian Clear Cell Adenocarcinoma DisGeNET BeFree 2.169E-5 1.512E-3 1.166E-2 2.722E-2 2 17
19 C0032285 Pneumonia DisGeNET Curated 2.398E-5 1.584E-3 1.222E-2 3.010E-2 4 476
20 C0005940 Bone Diseases DisGeNET Curated 2.809E-5 1.634E-3 1.260E-2 3.526E-2 3 153
21 C0023493 Adult T-Cell Lymphoma/Leukemia DisGeNET Curated 2.843E-5 1.634E-3 1.260E-2 3.568E-2 4 497
22 C1292753 Primary Effusion Lymphoma DisGeNET BeFree 2.865E-5 1.634E-3 1.260E-2 3.595E-2 3 154
23 C0014740 Erythema Chronicum Migrans DisGeNET BeFree 3.028E-5 1.642E-3 1.267E-2 3.800E-2 2 20
24 C0041327 Tuberculosis, Pulmonary DisGeNET Curated 3.152E-5 1.642E-3 1.267E-2 3.956E-2 3 159
25 C0001175 Acquired Immunodeficiency Syndrome DisGeNET Curated 3.272E-5 1.642E-3 1.267E-2 4.106E-2 3 161
26 C1260873 Aortic valve disorder DisGeNET BeFree 3.680E-5 1.710E-3 1.319E-2 4.618E-2 2 22
27 C0017677 Glossitis, Benign Migratory DisGeNET BeFree 3.680E-5 1.710E-3 1.319E-2 4.618E-2 2 22
28 C0017658 Glomerulonephritis DisGeNET Curated 3.986E-5 1.744E-3 1.345E-2
5.002E-2
 3 172
29 C0020725 Type II Mucolipidosis DisGeNET Curated 4.029E-5 1.744E-3 1.345E-2
5.057E-2
 2 23
30 C0003855 Arteriovenous fistula DisGeNET Curated 4.776E-5 1.998E-3 1.541E-2
5.994E-2
 2 25
31 C0014061 Tick-Borne Encephalitis DisGeNET BeFree 5.173E-5 2.094E-3 1.615E-2
6.492E-2
 2 26
32 C1519678 Tumor Expansion DisGeNET BeFree 5.585E-5 2.191E-3 1.689E-2
7.010E-2
 2 27
33 C0175697 Van der Woude syndrome DisGeNET Curated 5.974E-5 2.220E-3 1.712E-2
7.498E-2
 3 197
34 C0019104 Hemorrhagic Fevers, Viral DisGeNET BeFree 6.014E-5 2.220E-3 1.712E-2
7.547E-2
 2 28
35 C0014836 Escherichia coli Infections DisGeNET Curated 6.918E-5 2.481E-3 1.913E-2
8.682E-2
 2 30
36 C0740392 Infarction, Middle Cerebral Artery DisGeNET Curated 8.392E-5 2.925E-3 2.256E-2
1.053E-1
 2 33
37 C0393819 Polyradiculoneuropathy, Chronic Inflammatory Demyelinating DisGeNET BeFree 9.452E-5 3.206E-3 2.473E-2
1.186E-1
 2 35
38 C0026946 Mycoses DisGeNET BeFree 1.199E-4 3.959E-3 3.053E-2
1.504E-1
 3 249
39 C0340643 Dissection of aorta DisGeNET Curated 1.366E-4 4.395E-3 3.390E-2
1.714E-1
 2 42
40 C1275126 TNF receptor-associated periodic fever syndrome (TRAPS) DisGeNET Curated 1.432E-4 4.493E-3 3.466E-2
1.797E-1
 2 43
41 C0024591 Malignant hyperpyrexia due to anesthesia DisGeNET Curated 1.641E-4 5.022E-3 3.873E-2
2.059E-1
 2 46
42 C2718067 Alcoholic Steatohepatitis DisGeNET BeFree 1.713E-4 5.119E-3 3.948E-2
2.150E-1
 2 47
43 C1411966 Clostridium; difficile (disorder) DisGeNET BeFree 2.019E-4 5.589E-3 4.310E-2
2.534E-1
 2 51
44 C1519666 Tumor-Associated Vasculature DisGeNET BeFree 2.099E-4 5.589E-3 4.310E-2
2.634E-1
 2 52
45 C0005941 Bone Diseases, Developmental DisGeNET Curated 2.099E-4 5.589E-3 4.310E-2
2.634E-1
 2 52
46 C0563625 Agnosia for Pain DisGeNET BeFree 2.099E-4 5.589E-3 4.310E-2
2.634E-1
 2 52
47 C3714636 Pneumonitis DisGeNET BeFree 2.270E-4 5.589E-3 4.310E-2
2.849E-1
 3 309
48 C0018081 Gonorrhea DisGeNET BeFree 2.349E-4 5.589E-3 4.310E-2
2.949E-1
 2 55
49 C0162872 Aortic Aneurysm, Thoracic DisGeNET Curated 2.349E-4 5.589E-3 4.310E-2
2.949E-1
 2 55
50 C1136033 Cutaneous Mastocytosis DisGeNET Curated 2.436E-4 5.589E-3 4.310E-2
3.057E-1
 2 56
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