|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
12456676
|
Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1.
|
Pubmed
|
3.820E-17
|
1.803E-14
|
1.214E-13
|
1.803E-14
|
5
|
11
|
|
2
|
9341169
|
Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin.
|
Pubmed
|
2.763E-14
|
6.521E-12
|
4.392E-11
|
1.304E-11
|
4
|
7
|
|
3
|
11894096
|
The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.
|
Pubmed
|
2.604E-13
|
4.098E-11
|
2.760E-10
|
1.229E-10
|
4
|
11
|
|
4
|
9315708
|
SH3 domain-dependent interactions of endophilin with amphiphysin.
|
Pubmed
|
6.031E-12
|
7.117E-10
|
4.794E-9
|
2.847E-9
|
3
|
3
|
|
5
|
11384986
|
Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase.
|
Pubmed
|
2.412E-11
|
2.277E-9
|
1.534E-8
|
1.139E-8
|
3
|
4
|
|
6
|
27093085
|
Calmodulin Promotes N-BAR Domain-Mediated Membrane Constriction and Endocytosis.
|
Pubmed
|
6.030E-11
|
4.744E-9
|
3.195E-8
|
2.846E-8
|
3
|
5
|
|
7
|
10764144
|
The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis.
|
Pubmed
|
1.206E-10
|
8.131E-9
|
5.477E-8
|
5.692E-8
|
3
|
6
|
|
8
|
10542231
|
The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.
|
Pubmed
|
2.110E-10
|
1.245E-8
|
8.385E-8
|
9.960E-8
|
3
|
7
|
|
9
|
16696976
|
Two mechanistically distinct forms of endocytosis in adrenal chromaffin cells: Differential effects of SH3 domains and amphiphysin antagonism.
|
Pubmed
|
3.376E-10
|
1.593E-8
|
1.073E-7
|
1.593E-7
|
3
|
8
|
|
10
|
16115810
|
Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.
|
Pubmed
|
3.376E-10
|
1.593E-8
|
1.073E-7
|
1.593E-7
|
3
|
8
|
|
11
|
9630982
|
Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins.
|
Pubmed
|
2.741E-9
|
1.176E-7
|
7.922E-7
|
1.294E-6
|
3
|
15
|
|
12
|
10087302
|
Genetic mapping of eight SH3 domain genes on seven mouse chromosomes.
|
Pubmed
|
1.565E-8
|
6.154E-7
|
4.145E-6
|
7.385E-6
|
3
|
26
|
|
13
|
9182667
|
Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle.
|
Pubmed
|
3.839E-8
|
1.294E-6
|
8.718E-6
|
1.812E-5
|
2
|
2
|
|
14
|
27112121
|
Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy.
|
Pubmed
|
3.839E-8
|
1.294E-6
|
8.718E-6
|
1.812E-5
|
2
|
2
|
|
15
|
9603201
|
Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites.
|
Pubmed
|
1.152E-7
|
2.363E-6
|
1.592E-5
|
5.436E-5
|
2
|
3
|
|
16
|
15978591
|
Direct interaction between metastasis-associated protein 1 and endophilin 3.
|
Pubmed
|
1.152E-7
|
2.363E-6
|
1.592E-5
|
5.436E-5
|
2
|
3
|
|
17
|
10535961
|
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.
|
Pubmed
|
1.152E-7
|
2.363E-6
|
1.592E-5
|
5.436E-5
|
2
|
3
|
|
18
|
11161816
|
SH3GLB, a new endophilin-related protein family featuring an SH3 domain.
|
Pubmed
|
1.152E-7
|
2.363E-6
|
1.592E-5
|
5.436E-5
|
2
|
3
|
|
19
|
11709703
|
Amphiphysin IIb-1, a novel splicing variant of amphiphysin II, regulates p73beta function through protein-protein interactions.
|
Pubmed
|
1.152E-7
|
2.363E-6
|
1.592E-5
|
5.436E-5
|
2
|
3
|
|
20
|
9736607
|
Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation.
|
Pubmed
|
1.152E-7
|
2.363E-6
|
1.592E-5
|
5.436E-5
|
2
|
3
|
|
21
|
18093523
|
The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals.
|
Pubmed
|
1.152E-7
|
2.363E-6
|
1.592E-5
|
5.436E-5
|
2
|
3
|
|
22
|
15919751
|
Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance.
|
Pubmed
|
1.152E-7
|
2.363E-6
|
1.592E-5
|
5.436E-5
|
2
|
3
|
|
23
|
9348539
|
Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis.
|
Pubmed
|
1.152E-7
|
2.363E-6
|
1.592E-5
|
5.436E-5
|
2
|
3
|
|
24
|
22998870
|
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.
|
Pubmed
|
2.303E-7
|
4.026E-6
|
2.712E-5
|
1.087E-4
|
2
|
4
|
|
25
|
10764771
|
Inhibition of phospholipase D by amphiphysins.
|
Pubmed
|
2.303E-7
|
4.026E-6
|
2.712E-5
|
1.087E-4
|
2
|
4
|
|
26
|
9122235
|
EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.
|
Pubmed
|
2.303E-7
|
4.026E-6
|
2.712E-5
|
1.087E-4
|
2
|
4
|
|
27
|
10816441
|
Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins.
|
Pubmed
|
2.303E-7
|
4.026E-6
|
2.712E-5
|
1.087E-4
|
2
|
4
|
|
28
|
9238017
|
The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain.
|
Pubmed
|
3.838E-7
|
5.328E-6
|
3.588E-5
|
1.811E-4
|
2
|
5
|
|
29
|
12034747
|
Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.
|
Pubmed
|
3.838E-7
|
5.328E-6
|
3.588E-5
|
1.811E-4
|
2
|
5
|
|
30
|
14704270
|
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses.
|
Pubmed
|
3.838E-7
|
5.328E-6
|
3.588E-5
|
1.811E-4
|
2
|
5
|
|
31
|
25471590
|
Upregulation of Parkin in endophilin mutant mice.
|
Pubmed
|
3.838E-7
|
5.328E-6
|
3.588E-5
|
1.811E-4
|
2
|
5
|
|
32
|
27720640
|
Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.
|
Pubmed
|
3.838E-7
|
5.328E-6
|
3.588E-5
|
1.811E-4
|
2
|
5
|
|
33
|
11877424
|
Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate.
|
Pubmed
|
3.838E-7
|
5.328E-6
|
3.588E-5
|
1.811E-4
|
2
|
5
|
|
34
|
26506308
|
Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton.
|
Pubmed
|
3.838E-7
|
5.328E-6
|
3.588E-5
|
1.811E-4
|
2
|
5
|
|
35
|
9169142
|
A novel SH3-containing human gene family preferentially expressed in the central nervous system.
|
Pubmed
|
5.756E-7
|
6.038E-6
|
4.067E-5
|
2.717E-4
|
2
|
6
|
|
36
|
24076656
|
Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis.
|
Pubmed
|
5.756E-7
|
6.038E-6
|
4.067E-5
|
2.717E-4
|
2
|
6
|
|
37
|
9195986
|
Identification and characterization of a nerve terminal-enriched amphiphysin isoform.
|
Pubmed
|
5.756E-7
|
6.038E-6
|
4.067E-5
|
2.717E-4
|
2
|
6
|
|
38
|
26613292
|
Multiple Src Homology 3 Binding to the Ubiquitin Ligase Itch Conserved Proline-Rich Region.
|
Pubmed
|
5.756E-7
|
6.038E-6
|
4.067E-5
|
2.717E-4
|
2
|
6
|
|
39
|
17437541
|
Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis.
|
Pubmed
|
5.756E-7
|
6.038E-6
|
4.067E-5
|
2.717E-4
|
2
|
6
|
|
40
|
23187129
|
Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.
|
Pubmed
|
5.756E-7
|
6.038E-6
|
4.067E-5
|
2.717E-4
|
2
|
6
|
|
41
|
9238627
|
Binding properties of SH3 peptide ligands identified from phage-displayed random peptide libraries.
|
Pubmed
|
5.756E-7
|
6.038E-6
|
4.067E-5
|
2.717E-4
|
2
|
6
|
|
42
|
23785143
|
A local, periactive zone endocytic machinery at photoreceptor synapses in close vicinity to synaptic ribbons.
|
Pubmed
|
5.756E-7
|
6.038E-6
|
4.067E-5
|
2.717E-4
|
2
|
6
|
|
43
|
28235806
|
Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.
|
Pubmed
|
5.756E-7
|
6.038E-6
|
4.067E-5
|
2.717E-4
|
2
|
6
|
|
44
|
18647389
|
The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins.
|
Pubmed
|
5.756E-7
|
6.038E-6
|
4.067E-5
|
2.717E-4
|
2
|
6
|
|
45
|
17244534
|
Ubiquitin binds to and regulates a subset of SH3 domains.
|
Pubmed
|
5.756E-7
|
6.038E-6
|
4.067E-5
|
2.717E-4
|
2
|
6
|
|
46
|
22099461
|
Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission.
|
Pubmed
|
8.058E-7
|
7.924E-6
|
5.337E-5
|
3.803E-4
|
2
|
7
|
|
47
|
9280305
|
Clathrin interacts specifically with amphiphysin and is displaced by dynamin.
|
Pubmed
|
8.058E-7
|
7.924E-6
|
5.337E-5
|
3.803E-4
|
2
|
7
|
|
48
|
12558988
|
Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin.
|
Pubmed
|
8.058E-7
|
7.924E-6
|
5.337E-5
|
3.803E-4
|
2
|
7
|
|
49
|
11894095
|
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.
|
Pubmed
|
1.074E-6
|
9.390E-6
|
6.324E-5
|
5.071E-4
|
2
|
8
|
|
50
|
15834155
|
Kinetics of Src homology 3 domain association with the proline-rich domain of dynamins: specificity, occlusion, and the effects of phosphorylation.
|
Pubmed
|
1.074E-6
|
9.390E-6
|
6.324E-5
|
5.071E-4
|
2
|
8
|