Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc344_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 56 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042056 chemoattractant activity 3.484E-5 1.951E-3 8.998E-3 1.951E-3 2 29
2 GO:0008083 growth factor activity 1.152E-3 1.660E-2
7.653E-2
6.454E-2
 2 166
3 GO:0008201 heparin binding 1.166E-3 1.660E-2
7.653E-2
6.531E-2
 2 167
4 GO:0005539 glycosaminoglycan binding 1.994E-3 1.660E-2
7.653E-2
1.116E-1
 2 219
5 GO:0005125 cytokine activity 2.048E-3 1.660E-2
7.653E-2
1.147E-1
 2 222
6 GO:0004568 chitinase activity 2.249E-3 1.660E-2
7.653E-2
1.259E-1
 1 7
7 GO:0005113 patched binding 2.570E-3 1.660E-2
7.653E-2
1.439E-1
 1 8
8 GO:0008061 chitin binding 2.570E-3 1.660E-2
7.653E-2
1.439E-1
 1 8
9 GO:1901681 sulfur compound binding 2.795E-3 1.660E-2
7.653E-2
1.565E-1
 2 260
10 GO:0039706 co-receptor binding 3.211E-3 1.660E-2
7.653E-2
1.798E-1
 1 10
11 GO:0070700 BMP receptor binding 3.532E-3 1.660E-2
7.653E-2
1.978E-1
 1 11
12 GO:0031078 histone deacetylase activity (H3-K14 specific) 3.853E-3 1.660E-2
7.653E-2
2.157E-1
 1 12
13 GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) 3.853E-3 1.660E-2
7.653E-2
2.157E-1
 1 12
14 GO:0005159 insulin-like growth factor receptor binding 4.814E-3 1.890E-2
8.718E-2
2.696E-1
 1 15
15 GO:0017136 NAD-dependent histone deacetylase activity 5.134E-3 1.890E-2
8.718E-2
2.875E-1
 1 16
16 GO:0034979 NAD-dependent protein deacetylase activity 5.454E-3 1.890E-2
8.718E-2
3.054E-1
 1 17
17 GO:0035259 glucocorticoid receptor binding 6.094E-3 1.890E-2
8.718E-2
3.413E-1
 1 19
18 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 6.094E-3 1.890E-2
8.718E-2
3.413E-1
 1 19
19 GO:0033612 receptor serine/threonine kinase binding 6.414E-3 1.890E-2
8.718E-2
3.592E-1
 1 20
20 GO:0071889 14-3-3 protein binding 7.373E-3 2.065E-2
9.521E-2
4.129E-1
 1 23
21 GO:0019789 SUMO transferase activity 8.012E-3 2.137E-2
9.853E-2
4.487E-1
 1 25
22 GO:0005104 fibroblast growth factor receptor binding 8.970E-3 2.283E-2
1.053E-1
5.023E-1
 1 28
23 GO:0017080 sodium channel regulator activity 1.088E-2 2.650E-2
1.222E-1
6.095E-1
 1 34
24 GO:0004407 histone deacetylase activity 1.343E-2 2.961E-2
1.366E-1
7.521E-1
 1 42
25 GO:0016303 1-phosphatidylinositol-3-kinase activity 1.375E-2 2.961E-2
1.366E-1
7.699E-1
 1 43
26 GO:0033558 protein deacetylase activity 1.375E-2 2.961E-2
1.366E-1
7.699E-1
 1 43
27 GO:0005160 transforming growth factor beta receptor binding 1.692E-2 3.309E-2
1.526E-1
9.477E-1
 1 53
28 GO:0030374 nuclear receptor transcription coactivator activity 1.724E-2 3.309E-2
1.526E-1
9.654E-1
 1 54
29 GO:0052742 phosphatidylinositol kinase activity 1.851E-2 3.309E-2
1.526E-1
1.000E0
 1 58
30 GO:0070491 repressing transcription factor binding 1.914E-2 3.309E-2
1.526E-1
1.000E0
 1 60
31 GO:0033613 activating transcription factor binding 1.946E-2 3.309E-2
1.526E-1
1.000E0
 1 61
32 GO:0005080 protein kinase C binding 1.977E-2 3.309E-2
1.526E-1
1.000E0
 1 62
33 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1.977E-2 3.309E-2
1.526E-1
1.000E0
 1 62
34 GO:0019213 deacetylase activity 2.009E-2 3.309E-2
1.526E-1
1.000E0
 1 63
35 GO:0052813 phosphatidylinositol bisphosphate kinase activity 2.293E-2 3.669E-2
1.692E-1
1.000E0
 1 72
36 GO:0035004 phosphatidylinositol 3-kinase activity 2.451E-2 3.757E-2
1.732E-1
1.000E0
 1 77
37 GO:0005201 extracellular matrix structural constituent 2.482E-2 3.757E-2
1.732E-1
1.000E0
 1 78
38 GO:0035258 steroid hormone receptor binding 2.828E-2 4.106E-2
1.893E-1
1.000E0
 1 89
39 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2.859E-2 4.106E-2
1.893E-1
1.000E0
 1 90
Show 34 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 1043 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001525 angiogenesis 5.525E-8 5.762E-5 4.338E-4 5.762E-5 5 464
2 GO:0051216 cartilage development 1.792E-7 9.346E-5 7.035E-4 1.869E-4 4 197
3 GO:0001649 osteoblast differentiation 2.946E-7 1.024E-4 7.711E-4 3.073E-4 4 223
4 GO:1901342 regulation of vasculature development 5.791E-7 1.245E-4 9.373E-4 6.040E-4 4 264
5 GO:0061448 connective tissue development 5.969E-7 1.245E-4 9.373E-4 6.225E-4 4 266
6 GO:0033088 negative regulation of immature T cell proliferation in thymus 8.647E-7 1.503E-4 1.131E-3 9.019E-4 2 5
7 GO:0010595 positive regulation of endothelial cell migration 1.053E-6 1.503E-4 1.131E-3 1.099E-3 3 71
8 GO:0002040 sprouting angiogenesis 1.194E-6 1.503E-4 1.131E-3 1.246E-3 3 74
9 GO:0033087 negative regulation of immature T cell proliferation 1.297E-6 1.503E-4 1.131E-3 1.353E-3 2 6
10 GO:0033085 negative regulation of T cell differentiation in thymus 3.111E-6 2.753E-4 2.072E-3 3.245E-3 2 9
11 GO:0001503 ossification 3.163E-6 2.753E-4 2.072E-3 3.299E-3 4 404
12 GO:0060537 muscle tissue development 3.519E-6 2.753E-4 2.072E-3 3.671E-3 4 415
13 GO:0033084 regulation of immature T cell proliferation in thymus 3.888E-6 2.753E-4 2.072E-3 4.056E-3 2 10
14 GO:2000399 negative regulation of thymocyte aggregation 3.888E-6 2.753E-4 2.072E-3 4.056E-3 2 10
15 GO:0010634 positive regulation of epithelial cell migration 3.959E-6 2.753E-4 2.072E-3 4.129E-3 3 110
16 GO:0033080 immature T cell proliferation in thymus 4.752E-6 2.962E-4 2.230E-3 4.956E-3 2 11
17 GO:0010594 regulation of endothelial cell migration 5.017E-6 2.962E-4 2.230E-3 5.233E-3 3 119
18 GO:0045667 regulation of osteoblast differentiation 5.542E-6 2.962E-4 2.230E-3 5.781E-3 3 123
19 GO:0033083 regulation of immature T cell proliferation 5.701E-6 2.962E-4 2.230E-3 5.946E-3 2 12
20 GO:0016202 regulation of striated muscle tissue development 5.818E-6 2.962E-4 2.230E-3 6.068E-3 3 125
21 GO:0048634 regulation of muscle organ development 6.103E-6 2.962E-4 2.230E-3 6.365E-3 3 127
22 GO:1901861 regulation of muscle tissue development 6.248E-6 2.962E-4 2.230E-3 6.517E-3 3 128
23 GO:0033079 immature T cell proliferation 6.737E-6 3.047E-4 2.294E-3 7.027E-3 2 13
24 GO:0045766 positive regulation of angiogenesis 7.011E-6 3.047E-4 2.294E-3 7.313E-3 3 133
25 GO:1904018 positive regulation of vasculature development 9.864E-6 4.002E-4 3.013E-3 1.029E-2 3 149
26 GO:0072498 embryonic skeletal joint development 1.036E-5 4.002E-4 3.013E-3 1.081E-2 2 16
27 GO:1903672 positive regulation of sprouting angiogenesis 1.036E-5 4.002E-4 3.013E-3 1.081E-2 2 16
28 GO:0043542 endothelial cell migration 1.315E-5 4.899E-4 3.688E-3 1.372E-2 3 164
29 GO:0010632 regulation of epithelial cell migration 1.598E-5 5.468E-4 4.116E-3 1.667E-2 3 175
30 GO:0050679 positive regulation of epithelial cell proliferation 1.598E-5 5.468E-4 4.116E-3 1.667E-2 3 175
31 GO:0048592 eye morphogenesis 1.625E-5 5.468E-4 4.116E-3 1.695E-2 3 176
32 GO:0048754 branching morphogenesis of an epithelial tube 1.857E-5 6.052E-4 4.556E-3 1.937E-2 3 184
33 GO:0070374 positive regulation of ERK1 and ERK2 cascade 2.044E-5 6.460E-4 4.863E-3 2.132E-2 3 190
34 GO:0048745 smooth muscle tissue development 2.380E-5 7.301E-4 5.496E-3 2.482E-2 2 24
35 GO:0001759 organ induction 2.587E-5 7.542E-4 5.677E-3 2.698E-2 2 25
36 GO:0030278 regulation of ossification 2.603E-5 7.542E-4 5.677E-3 2.715E-2 3 206
37 GO:0043536 positive regulation of blood vessel endothelial cell migration 3.025E-5 8.493E-4 6.393E-3 3.156E-2 2 27
38 GO:0030324 lung development 3.212E-5 8.493E-4 6.393E-3 3.350E-2 3 221
39 GO:0061138 morphogenesis of a branching epithelium 3.212E-5 8.493E-4 6.393E-3 3.350E-2 3 221
40 GO:0030323 respiratory tube development 3.388E-5 8.493E-4 6.393E-3 3.534E-2 3 225
41 GO:0032967 positive regulation of collagen biosynthetic process 3.499E-5 8.493E-4 6.393E-3 3.649E-2 2 29
42 GO:0010714 positive regulation of collagen metabolic process 3.748E-5 8.493E-4 6.393E-3 3.909E-2 2 30
43 GO:0010631 epithelial cell migration 3.858E-5 8.493E-4 6.393E-3 4.024E-2 3 235
44 GO:0009612 response to mechanical stimulus 3.907E-5 8.493E-4 6.393E-3 4.075E-2 3 236
45 GO:0001763 morphogenesis of a branching structure 3.957E-5 8.493E-4 6.393E-3 4.127E-2 3 237
46 GO:0061036 positive regulation of cartilage development 4.006E-5 8.493E-4 6.393E-3 4.178E-2 2 31
47 GO:0090132 epithelium migration 4.007E-5 8.493E-4 6.393E-3 4.179E-2 3 238
48 GO:0045765 regulation of angiogenesis 4.057E-5 8.493E-4 6.393E-3 4.232E-2 3 239
49 GO:2000398 regulation of thymocyte aggregation 4.272E-5 8.493E-4 6.393E-3 4.456E-2 2 32
50 GO:0033081 regulation of T cell differentiation in thymus 4.272E-5 8.493E-4 6.393E-3 4.456E-2 2 32
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 5 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031012 extracellular matrix 2.383E-4 1.191E-3 2.720E-3 1.191E-3 3 444
2 GO:0014704 intercalated disc 1.812E-2 2.768E-2
6.321E-2
9.061E-2
 1 58
3 GO:0000118 histone deacetylase complex 1.967E-2 2.768E-2
6.321E-2
9.835E-2
 1 63
4 GO:0044291 cell-cell contact zone 2.215E-2 2.768E-2
6.321E-2
1.107E-1
 1 71

4: Human Phenotype [Display Chart] 3 input genes in category / 412 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0010240 Hypoplasia of the middle phalanges of the hand 2.665E-4 2.626E-2
1.733E-1
1.098E-1
 2 45
2 HP:0005819 Short middle phalanx of finger 2.665E-4 2.626E-2
1.733E-1
1.098E-1
 2 45
3 HP:0009843 Aplasia/Hypoplasia of the middle phalanges of the hand 3.706E-4 2.626E-2
1.733E-1
1.527E-1
 2 53
4 HP:0009833 Abnormal middle phalanx morphology of the hand 4.139E-4 2.626E-2
1.733E-1
1.705E-1
 2 56
5 HP:0009688 Cone-shaped epiphysis of the thumb 6.373E-4 2.626E-2
1.733E-1
2.626E-1
 1 1
6 HP:0006438 Enlargement of the distal femoral epiphysis 6.373E-4 2.626E-2
1.733E-1
2.626E-1
 1 1
7 HP:0010017 Cone-shaped epiphysis of the 1st metacarpal 6.373E-4 2.626E-2
1.733E-1
2.626E-1
 1 1
8 HP:0030276 Small scrotum 6.373E-4 2.626E-2
1.733E-1
2.626E-1
 1 1
9 HP:0010999 Aplasia of the optic tract 6.373E-4 2.626E-2
1.733E-1
2.626E-1
 1 1
10 HP:0010014 Abnormality of the epiphysis of the 1st metacarpal 6.373E-4 2.626E-2
1.733E-1
2.626E-1
 1 1
11 HP:0003099 Fibular overgrowth 1.274E-3 2.715E-2
1.792E-1
5.251E-1
 1 2
12 HP:0011000 Aplasia/Hypoplasia of the optic tract 1.274E-3 2.715E-2
1.792E-1
5.251E-1
 1 2
13 HP:0010270 Cone-shaped epiphyses of the proximal phalanges of the hand 1.274E-3 2.715E-2
1.792E-1
5.251E-1
 1 2
14 HP:0008789 Cone-shaped capital femoral epiphysis 1.274E-3 2.715E-2
1.792E-1
5.251E-1
 1 2
15 HP:0004279 Short palm 1.457E-3 2.715E-2
1.792E-1
6.004E-1
 2 105
16 HP:0010049 Short metacarpal 1.485E-3 2.715E-2
1.792E-1
6.119E-1
 2 106
17 HP:0005914 Aplasia/Hypoplasia involving the metacarpal bones 1.687E-3 2.715E-2
1.792E-1
6.951E-1
 2 113
18 HP:0010538 Small sella turcica 1.911E-3 2.715E-2
1.792E-1
7.874E-1
 1 3
19 HP:0006059 Cone-shaped metacarpal epiphyses 1.911E-3 2.715E-2
1.792E-1
7.874E-1
 1 3
20 HP:0012521 Optic nerve aplasia 1.911E-3 2.715E-2
1.792E-1
7.874E-1
 1 3
21 HP:0010085 Aplasia/Hypoplasia of the proximal phalanx of the hallux 1.911E-3 2.715E-2
1.792E-1
7.874E-1
 1 3
22 HP:0009638 Short proximal phalanx of thumb 1.911E-3 2.715E-2
1.792E-1
7.874E-1
 1 3
23 HP:0009600 Flexion contracture of thumb 1.911E-3 2.715E-2
1.792E-1
7.874E-1
 1 3
24 HP:0006213 Thin proximal phalanges with broad epiphyses of the hand 1.911E-3 2.715E-2
1.792E-1
7.874E-1
 1 3
25 HP:0010590 Abnormality of the distal femoral epiphysis 1.911E-3 2.715E-2
1.792E-1
7.874E-1
 1 3
26 HP:0010575 Dysplasia of the femoral head 1.911E-3 2.715E-2
1.792E-1
7.874E-1
 1 3
27 HP:0009279 Radial deviation of the 4th finger 1.911E-3 2.715E-2
1.792E-1
7.874E-1
 1 3
28 HP:0006165 Proportionate shortening of all digits 1.911E-3 2.715E-2
1.792E-1
7.874E-1
 1 3
29 HP:0006146 Broad metacarpal epiphyses 1.911E-3 2.715E-2
1.792E-1
7.874E-1
 1 3
30 HP:0001764 Small feet 2.369E-3 2.916E-2
1.924E-1
9.758E-1
 2 134
31 HP:0001773 Short foot 2.369E-3 2.916E-2
1.924E-1
9.758E-1
 2 134
32 HP:0001766 Short feet 2.369E-3 2.916E-2
1.924E-1
9.758E-1
 2 134
33 HP:0001772 Talipes equinovalgus 2.511E-3 2.916E-2
1.924E-1
1.000E0
 2 138
34 HP:0010052 Abnormality of the proximal phalanx of the hallux 2.548E-3 2.916E-2
1.924E-1
1.000E0
 1 4
35 HP:0005194 Flattened metatarsal heads 2.548E-3 2.916E-2
1.924E-1
1.000E0
 1 4
36 HP:0009599 Abnormality of thumb epiphysis 2.548E-3 2.916E-2
1.924E-1
1.000E0
 1 4
37 HP:0005916 Abnormal metacarpal morphology 2.733E-3 3.043E-2
2.008E-1
1.000E0
 2 144
38 HP:0010245 Abnormality of the epiphyses of the proximal phalanges of the hand 3.184E-3 3.051E-2
2.013E-1
1.000E0
 1 5
39 HP:0001204 Distal symphalangism of hands 3.184E-3 3.051E-2
2.013E-1
1.000E0
 1 5
40 HP:0009909 Uplifted earlobe 3.184E-3 3.051E-2
2.013E-1
1.000E0
 1 5
41 HP:0006236 Slender metacarpals 3.184E-3 3.051E-2
2.013E-1
1.000E0
 1 5
42 HP:0007068 Inferior vermis hypoplasia 3.184E-3 3.051E-2
2.013E-1
1.000E0
 1 5
43 HP:0009273 Deviation of the 4th finger 3.184E-3 3.051E-2
2.013E-1
1.000E0
 1 5
44 HP:0001769 Broad foot 3.327E-3 3.115E-2
2.056E-1
1.000E0
 2 159
45 HP:0009462 Radial deviation of the 3rd finger 3.820E-3 3.279E-2
2.164E-1
1.000E0
 1 6
46 HP:0004188 Abnormal 4th finger morphology 3.820E-3 3.279E-2
2.164E-1
1.000E0
 1 6
47 HP:0100263 Distal symphalangism 3.820E-3 3.279E-2
2.164E-1
1.000E0
 1 6
48 HP:0009629 Aplasia/Hypoplasia of the proximal phalanx of the thumb 3.820E-3 3.279E-2
2.164E-1
1.000E0
 1 6
49 HP:0001163 Abnormality of the metacarpal bones 4.023E-3 3.382E-2
2.232E-1
1.000E0
 2 175
50 HP:0010194 Aplasia/Hypoplasia of the middle phalanges of the toes 4.456E-3 3.464E-2
2.286E-1
1.000E0
 1 7
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 5 input genes in category / 637 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000767 abnormal smooth muscle morphology 3.218E-5 1.593E-2
1.121E-1
 2.050E-2 3 155
2 MP:0004214 abnormal long bone diaphysis morphology 1.040E-4 1.593E-2
1.121E-1
6.625E-2
 2 34
3 MP:0004672 short ribs 1.103E-4 1.593E-2
1.121E-1
7.025E-2
 2 35
4 MP:0006280 abnormal digit development 1.234E-4 1.593E-2
1.121E-1
7.860E-2
 2 37
5 MP:0020516 abnormal visceral yolk sac mesenchyme morphology 1.444E-4 1.593E-2
1.121E-1
9.201E-2
 2 40
6 MP:0003105 abnormal heart atrium morphology 1.613E-4 1.593E-2
1.121E-1
1.028E-1
 3 266
7 MP:0000065 abnormal bone marrow cavity morphology 1.750E-4 1.593E-2
1.121E-1
1.115E-1
 2 44
8 MP:0002672 abnormal pharyngeal arch artery morphology 3.600E-4 2.142E-2
1.507E-1
2.293E-1
 2 63
9 MP:0003419 delayed endochondral bone ossification 3.833E-4 2.142E-2
1.507E-1
2.442E-1
 2 65
10 MP:0008775 abnormal heart ventricle pressure 4.574E-4 2.142E-2
1.507E-1
2.914E-1
 2 71
11 MP:0002187 abnormal fibula morphology 4.574E-4 2.142E-2
1.507E-1
2.914E-1
 2 71
12 MP:0010414 partial atrioventricular septal defect 4.829E-4 2.142E-2
1.507E-1
3.076E-1
 1 1
13 MP:0010256 anterior cortical cataracts 4.829E-4 2.142E-2
1.507E-1
3.076E-1
 1 1
14 MP:0006377 abnormal vestibulocollic reflex 4.829E-4 2.142E-2
1.507E-1
3.076E-1
 1 1
15 MP:0008395 abnormal osteoblast differentiation 5.241E-4 2.142E-2
1.507E-1
3.338E-1
 2 76
16 MP:0001719 absent vitelline blood vessels 5.379E-4 2.142E-2
1.507E-1
3.427E-1
 2 77
17 MP:0000088 short mandible 8.527E-4 2.891E-2
2.034E-1
5.432E-1
 2 97
18 MP:0006250 abnormal line of Schwalbe morphology 9.655E-4 2.891E-2
2.034E-1
6.150E-1
 1 2
19 MP:0011851 abnormal embryonic cloaca development 9.655E-4 2.891E-2
2.034E-1
6.150E-1
 1 2
20 MP:0011783 abnormal ureteral orifice morphology 9.655E-4 2.891E-2
2.034E-1
6.150E-1
 1 2
21 MP:0003248 loss of glutamate neurons 9.655E-4 2.891E-2
2.034E-1
6.150E-1
 1 2
22 MP:0005592 abnormal vascular smooth muscle morphology 9.984E-4 2.891E-2
2.034E-1
6.360E-1
 2 105
23 MP:0000592 short tail 1.056E-3 2.924E-2
2.057E-1
6.726E-1
 2 108
24 MP:0011999 abnormal tail length 1.196E-3 3.074E-2
2.163E-1
7.620E-1
 2 115
25 MP:0003854 abnormal forelimb stylopod morphology 1.367E-3 3.074E-2
2.163E-1
8.709E-1
 2 123
26 MP:0010255 cortical cataracts 1.448E-3 3.074E-2
2.163E-1
9.224E-1
 1 3
27 MP:0011264 abnormal cardiac mesenchyme morphology 1.448E-3 3.074E-2
2.163E-1
9.224E-1
 1 3
28 MP:0010969 absent compact bone 1.448E-3 3.074E-2
2.163E-1
9.224E-1
 1 3
29 MP:0003855 abnormal forelimb zeugopod morphology 1.457E-3 3.074E-2
2.163E-1
9.280E-1
 2 127
30 MP:0005312 pericardial effusion 1.742E-3 3.074E-2
2.163E-1
1.000E0
 2 139
31 MP:0008272 abnormal endochondral bone ossification 1.843E-3 3.074E-2
2.163E-1
1.000E0
 2 143
32 MP:0030384 short facial bone 1.868E-3 3.074E-2
2.163E-1
1.000E0
 2 144
33 MP:0000060 delayed bone ossification 1.894E-3 3.074E-2
2.163E-1
1.000E0
 2 145
34 MP:0009203 external male genitalia hypoplasia 1.930E-3 3.074E-2
2.163E-1
1.000E0
 1 4
35 MP:0013790 single external naris 1.930E-3 3.074E-2
2.163E-1
1.000E0
 1 4
36 MP:0003824 decreased left ventricle developed pressure 1.930E-3 3.074E-2
2.163E-1
1.000E0
 1 4
37 MP:0013283 failure of ventral body wall closure 1.930E-3 3.074E-2
2.163E-1
1.000E0
 1 4
38 MP:0012740 abnormal posterior primitive streak morphology 1.930E-3 3.074E-2
2.163E-1
1.000E0
 1 4
39 MP:0004224 absent trabecular meshwork 1.930E-3 3.074E-2
2.163E-1
1.000E0
 1 4
40 MP:0010455 aortopulmonary window 1.930E-3 3.074E-2
2.163E-1
1.000E0
 1 4
41 MP:0004592 small mandible 2.217E-3 3.415E-2
2.402E-1
1.000E0
 2 157
42 MP:0004986 abnormal osteoblast morphology 2.301E-3 3.415E-2
2.402E-1
1.000E0
 2 160
43 MP:0006261 annular pancreas 2.412E-3 3.415E-2
2.402E-1
1.000E0
 1 5
44 MP:0004517 decreased vestibular hair cell stereocilia number 2.412E-3 3.415E-2
2.402E-1
1.000E0
 1 5
45 MP:0030372 enlarged Meckel's cartilage 2.412E-3 3.415E-2
2.402E-1
1.000E0
 1 5
46 MP:0003410 abnormal artery development 2.475E-3 3.427E-2
2.411E-1
1.000E0
 2 166
47 MP:0006279 abnormal limb development 2.685E-3 3.462E-2
2.436E-1
1.000E0
 2 173
48 MP:0009052 anal stenosis 2.894E-3 3.462E-2
2.436E-1
1.000E0
 1 6
49 MP:0011488 abnormal ureterovesical junction morphology 2.894E-3 3.462E-2
2.436E-1
1.000E0
 1 6
50 MP:0010252 anterior subcapsular cataracts 2.894E-3 3.462E-2
2.436E-1
1.000E0
 1 6
Show 45 more annotations

6: Domain [Display Chart] 6 input genes in category / 58 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR028538 CHI3L1 InterPro 3.203E-4 3.482E-3 1.618E-2 1.857E-2 1 1
2 IPR028223 FGF2 InterPro 3.203E-4 3.482E-3 1.618E-2 1.857E-2 1 1
3 IPR033385 IHH InterPro 3.203E-4 3.482E-3 1.618E-2 1.857E-2 1 1
4 PS50817 INTEIN N TER PROSITE 6.404E-4 3.482E-3 1.618E-2 3.714E-2 1 2
5 IPR006141 Intein N InterPro 6.404E-4 3.482E-3 1.618E-2 3.714E-2 1 2
6 SM00306 HintN SMART 9.605E-4 3.482E-3 1.618E-2
5.571E-2
 1 3
7 IPR009045 Hedgehog sig/DD-Pept Zn-bd dom InterPro 9.605E-4 3.482E-3 1.618E-2
5.571E-2
 1 3
8 3.30.1380.10 - Gene3D 9.605E-4 3.482E-3 1.618E-2
5.571E-2
 1 3
9 PF01079 Hint Pfam 9.605E-4 3.482E-3 1.618E-2
5.571E-2
 1 3
10 SM00305 HintC SMART 9.605E-4 3.482E-3 1.618E-2
5.571E-2
 1 3
11 IPR001767 Hint dom InterPro 9.605E-4 3.482E-3 1.618E-2
5.571E-2
 1 3
12 IPR003586 Hint dom C InterPro 9.605E-4 3.482E-3 1.618E-2
5.571E-2
 1 3
13 IPR001657 Hedgehog InterPro 9.605E-4 3.482E-3 1.618E-2
5.571E-2
 1 3
14 PF01085 HH signal Pfam 9.605E-4 3.482E-3 1.618E-2
5.571E-2
 1 3
15 IPR003587 Hint dom N InterPro 9.605E-4 3.482E-3 1.618E-2
5.571E-2
 1 3
16 IPR000320 Hedgehog signalling dom InterPro 9.605E-4 3.482E-3 1.618E-2
5.571E-2
 1 3
17 2.170.16.10 - Gene3D 1.281E-3 3.909E-3 1.816E-2
7.427E-2
 1 4
18 IPR017320 Histone deAcase II euk InterPro 1.281E-3 3.909E-3 1.816E-2
7.427E-2
 1 4
19 IPR028992 Hedgehog/Intein dom InterPro 1.281E-3 3.909E-3 1.816E-2
7.427E-2
 1 4
20 IPR029070 Chitinase insertion InterPro 1.600E-3 3.937E-3 1.829E-2
9.282E-2
 1 5
21 3.10.50.10 - Gene3D 1.600E-3 3.937E-3 1.829E-2
9.282E-2
 1 5
22 IPR001579 Glyco hydro 18 chit AS InterPro 1.920E-3 3.937E-3 1.829E-2
1.114E-1
 1 6
23 PF00244 14-3-3 Pfam 2.240E-3 3.937E-3 1.829E-2
1.299E-1
 1 7
24 IPR023410 14-3-3 domain InterPro 2.240E-3 3.937E-3 1.829E-2
1.299E-1
 1 7
25 PS00797 1433 2 PROSITE 2.240E-3 3.937E-3 1.829E-2
1.299E-1
 1 7
26 IPR023409 14-3-3 CS InterPro 2.240E-3 3.937E-3 1.829E-2
1.299E-1
 1 7
27 IPR011583 Chitinase II InterPro 2.240E-3 3.937E-3 1.829E-2
1.299E-1
 1 7
28 IPR001223 Glyco hydro18 cat InterPro 2.240E-3 3.937E-3 1.829E-2
1.299E-1
 1 7
29 PF00704 Glyco hydro 18 Pfam 2.240E-3 3.937E-3 1.829E-2
1.299E-1
 1 7
30 SM00636 Glyco 18 SMART 2.240E-3 3.937E-3 1.829E-2
1.299E-1
 1 7
31 PS00796 1433 1 PROSITE 2.240E-3 3.937E-3 1.829E-2
1.299E-1
 1 7
32 PS01095 CHITINASE 18 PROSITE 2.240E-3 3.937E-3 1.829E-2
1.299E-1
 1 7
33 SM00101 14 3 3 SMART 2.240E-3 3.937E-3 1.829E-2
1.299E-1
 1 7
34 IPR000308 14-3-3 InterPro 2.560E-3 4.366E-3 2.029E-2
1.485E-1
 1 8
35 3.40.800.20 - Gene3D 3.518E-3 5.370E-3 2.495E-2
2.041E-1
 1 11
36 IPR023801 His deacetylse dom InterPro 3.518E-3 5.370E-3 2.495E-2
2.041E-1
 1 11
37 PF00850 Hist deacetyl Pfam 3.518E-3 5.370E-3 2.495E-2
2.041E-1
 1 11
38 IPR000286 His deacetylse InterPro 3.518E-3 5.370E-3 2.495E-2
2.041E-1
 1 11
39 PF00167 FGF Pfam 7.026E-3 9.702E-3 4.508E-2
4.075E-1
 1 22
40 IPR002209 Fibroblast GF fam InterPro 7.026E-3 9.702E-3 4.508E-2
4.075E-1
 1 22
41 SM00442 FGF SMART 7.026E-3 9.702E-3 4.508E-2
4.075E-1
 1 22
42 PS00247 HBGF FGF PROSITE 7.026E-3 9.702E-3 4.508E-2
4.075E-1
 1 22
43 IPR028142 IL-1 fam/FGF fam InterPro 7.344E-3 9.906E-3 4.603E-2
4.260E-1
 1 23
44 IPR001111 TGF-b N InterPro 8.935E-3 1.152E-2
5.351E-2
5.182E-1
 1 28
45 PF00688 TGFb propeptide Pfam 8.935E-3 1.152E-2
5.351E-2
5.182E-1
 1 28
46 IPR015615 TGF-beta-rel InterPro 1.021E-2 1.259E-2
5.852E-2
5.919E-1
 1 32
47 IPR017948 TGFb CS InterPro 1.021E-2 1.259E-2
5.852E-2
5.919E-1
 1 32
48 3.20.20.80 - Gene3D 1.116E-2 1.267E-2
5.885E-2
6.472E-1
 1 35
49 IPR008996 Cytokine IL1-like InterPro 1.148E-2 1.267E-2
5.885E-2
6.656E-1
 1 36
50 PS00250 TGF BETA 1 PROSITE 1.179E-2 1.267E-2
5.885E-2
6.840E-1
 1 37
Show 45 more annotations

7: Pathway [Display Chart] 6 input genes in category / 209 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5883 Genes encoding secreted soluble factors MSigDB C2 BIOCARTA (v6.0) 3.931E-4 4.193E-2
2.483E-1
8.216E-2
 3 344
2 1268855 Diseases of signal transduction BioSystems: REACTOME 4.988E-4 4.193E-2
2.483E-1
1.042E-1
 3 373
3 1339127 HHAT G278V abrogates palmitoylation of Hh-Np BioSystems: REACTOME 1.445E-3 4.193E-2
2.483E-1
3.020E-1
 1 3
4 1026136 Signaling pathways regulating pluripotency of stem cells BioSystems: KEGG 1.803E-3 4.193E-2
2.483E-1
3.767E-1
 2 139
5 749777 Hippo signaling pathway BioSystems: KEGG 2.207E-3 4.193E-2
2.483E-1
4.613E-1
 2 154
6 1269389 FGFR1b ligand binding and activation BioSystems: REACTOME 2.889E-3 4.193E-2
2.483E-1
6.037E-1
 1 6
7 658418 Viral carcinogenesis BioSystems: KEGG 3.728E-3 4.193E-2
2.483E-1
7.791E-1
 2 201
8 782000 Proteoglycans in cancer BioSystems: KEGG 3.801E-3 4.193E-2
2.483E-1
7.944E-1
 2 203
9 1269635 Release of Hh-Np from the secreting cell BioSystems: REACTOME 3.850E-3 4.193E-2
2.483E-1
8.047E-1
 1 8
10 1269641 Ligand-receptor interactions BioSystems: REACTOME 3.850E-3 4.193E-2
2.483E-1
8.047E-1
 1 8
11 138084 Glypican 3 network BioSystems: Pathway Interaction Database 3.850E-3 4.193E-2
2.483E-1
8.047E-1
 1 8
12 1269401 FGFR2b ligand binding and activation BioSystems: REACTOME 4.811E-3 4.193E-2
2.483E-1
1.000E0
 1 10
13 1268868 Signaling by activated point mutants of FGFR1 BioSystems: REACTOME 5.291E-3 4.193E-2
2.483E-1
1.000E0
 1 11
14 1269755 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex BioSystems: REACTOME 5.770E-3 4.193E-2
2.483E-1
1.000E0
 1 12
15 1268875 Signaling by activated point mutants of FGFR3 BioSystems: REACTOME 5.770E-3 4.193E-2
2.483E-1
1.000E0
 1 12
16 1268874 FGFR3 mutant receptor activation BioSystems: REACTOME 5.770E-3 4.193E-2
2.483E-1
1.000E0
 1 12
17 1269390 FGFR1c ligand binding and activation BioSystems: REACTOME 5.770E-3 4.193E-2
2.483E-1
1.000E0
 1 12
18 1269415 Phospholipase C-mediated cascade; FGFR3 BioSystems: REACTOME 6.250E-3 4.193E-2
2.483E-1
1.000E0
 1 13
19 M18159 RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage MSigDB C2 BIOCARTA (v6.0) 6.250E-3 4.193E-2
2.483E-1
1.000E0
 1 13
20 1383021 FGFRL1 modulation of FGFR1 signaling BioSystems: REACTOME 6.250E-3 4.193E-2
2.483E-1
1.000E0
 1 13
21 1269412 FGFR3c ligand binding and activation BioSystems: REACTOME 6.250E-3 4.193E-2
2.483E-1
1.000E0
 1 13
22 1269402 FGFR2c ligand binding and activation BioSystems: REACTOME 6.250E-3 4.193E-2
2.483E-1
1.000E0
 1 13
23 1270347 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation BioSystems: REACTOME 6.250E-3 4.193E-2
2.483E-1
1.000E0
 1 13
24 1269410 FGFR3 ligand binding and activation BioSystems: REACTOME 6.250E-3 4.193E-2
2.483E-1
1.000E0
 1 13
25 1269420 FGFR4 ligand binding and activation BioSystems: REACTOME 6.729E-3 4.193E-2
2.483E-1
1.000E0
 1 14
26 1269424 Phospholipase C-mediated cascade; FGFR4 BioSystems: REACTOME 7.209E-3 4.193E-2
2.483E-1
1.000E0
 1 15
27 1270271 Activation of BAD and translocation to mitochondria BioSystems: REACTOME 7.209E-3 4.193E-2
2.483E-1
1.000E0
 1 15
28 M16884 Role of nicotinic acetylcholine receptors in the regulation of apoptosis MSigDB C2 BIOCARTA (v6.0) 7.688E-3 4.193E-2
2.483E-1
1.000E0
 1 16
29 1269388 FGFR1 ligand binding and activation BioSystems: REACTOME 7.688E-3 4.193E-2
2.483E-1
1.000E0
 1 16
30 1269394 Phospholipase C-mediated cascade: FGFR1 BioSystems: REACTOME 7.688E-3 4.193E-2
2.483E-1
1.000E0
 1 16
31 1270244 Extracellular matrix organization BioSystems: REACTOME 8.037E-3 4.193E-2
2.483E-1
1.000E0
 2 298
32 1268871 Activated point mutants of FGFR2 BioSystems: REACTOME 8.166E-3 4.193E-2
2.483E-1
1.000E0
 1 17
33 1269405 Phospholipase C-mediated cascade; FGFR2 BioSystems: REACTOME 8.645E-3 4.193E-2
2.483E-1
1.000E0
 1 18
34 1269642 Activation of SMO BioSystems: REACTOME 8.645E-3 4.193E-2
2.483E-1
1.000E0
 1 18
35 1269416 SHC-mediated cascade:FGFR3 BioSystems: REACTOME 8.645E-3 4.193E-2
2.483E-1
1.000E0
 1 18
36 1269417 PI-3K cascade:FGFR3 BioSystems: REACTOME 8.645E-3 4.193E-2
2.483E-1
1.000E0
 1 18
37 1383045 Signaling by FGFR2 IIIa TM BioSystems: REACTOME 9.124E-3 4.193E-2
2.483E-1
1.000E0
 1 19
38 1269425 SHC-mediated cascade:FGFR4 BioSystems: REACTOME 9.602E-3 4.193E-2
2.483E-1
1.000E0
 1 20
39 1269426 PI-3K cascade:FGFR4 BioSystems: REACTOME 9.602E-3 4.193E-2
2.483E-1
1.000E0
 1 20
40 138078 p38 signaling mediated by MAPKAP kinases BioSystems: Pathway Interaction Database 9.602E-3 4.193E-2
2.483E-1
1.000E0
 1 20
41 1269414 FRS-mediated FGFR3 signaling BioSystems: REACTOME 9.602E-3 4.193E-2
2.483E-1
1.000E0
 1 20
42 1269400 FGFR2 ligand binding and activation BioSystems: REACTOME 9.602E-3 4.193E-2
2.483E-1
1.000E0
 1 20
43 1270255 Syndecan interactions BioSystems: REACTOME 1.008E-2 4.193E-2
2.483E-1
1.000E0
 1 21
44 1269395 SHC-mediated cascade:FGFR1 BioSystems: REACTOME 1.008E-2 4.193E-2
2.483E-1
1.000E0
 1 21
45 1269396 PI-3K cascade:FGFR1 BioSystems: REACTOME 1.008E-2 4.193E-2
2.483E-1
1.000E0
 1 21
46 692234 PI3K-Akt signaling pathway BioSystems: KEGG 1.049E-2 4.193E-2
2.483E-1
1.000E0
 2 342
47 1268873 Signaling by FGFR3 in disease BioSystems: REACTOME 1.056E-2 4.193E-2
2.483E-1
1.000E0
 1 22
48 137950 Signaling events mediated by the Hedgehog family BioSystems: Pathway Interaction Database 1.056E-2 4.193E-2
2.483E-1
1.000E0
 1 22
49 1383047 Signaling by FGFR3 point mutants in cancer BioSystems: REACTOME 1.056E-2 4.193E-2
2.483E-1
1.000E0
 1 22
50 M15258 AKT Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.056E-2 4.193E-2
2.483E-1
1.000E0
 1 22
Show 45 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 4123 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12701101 Loss of the Tg737 protein results in skeletal patterning defects. Pubmed 1.205E-9 4.970E-6 4.424E-5 4.970E-6 3 16
2 20554972 Vegf regulates embryonic erythroid development through Gata1 modulation. Pubmed 3.810E-9 7.855E-6 6.992E-5 1.571E-5 3 23
3 22556407 Heparan sulfate facilitates FGF and BMP signaling to drive mesoderm differentiation of mouse embryonic stem cells. Pubmed 2.057E-8 1.211E-5 1.078E-4 8.480E-5 2 2
4 12361605 Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Pubmed 2.057E-8 1.211E-5 1.078E-4 8.480E-5 2 2
5 21855631 Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Pubmed 2.057E-8 1.211E-5 1.078E-4 8.480E-5 2 2
6 19213939 Signaling hierarchy regulating human endothelial cell development. Pubmed 2.057E-8 1.211E-5 1.078E-4 8.480E-5 2 2
7 15226637 Efficient cardiomyogenic differentiation of embryonic stem cell by fibroblast growth factor 2 and bone morphogenetic protein 2. Pubmed 2.057E-8 1.211E-5 1.078E-4 8.480E-5 2 2
8 15963767 Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Pubmed 4.473E-8 2.305E-5 2.052E-4 1.844E-4 3 51
9 9853822 Using EC and ES cell culture to study early development: recent observations on Indian hedgehog and Bmps. Pubmed 6.170E-8 2.826E-5 2.516E-4 2.544E-4 2 3
10 12399320 Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Pubmed 1.234E-7 4.625E-5 4.117E-4 5.087E-4 2 4
11 17556598 Differentiation of human embryonic stem cells in serum-free medium reveals distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis. Pubmed 1.234E-7 4.625E-5 4.117E-4 5.087E-4 2 4
12 21731673 Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Pubmed 1.395E-7 4.792E-5 4.265E-4 5.750E-4 4 378
13 12944425 Digit regeneration is regulated by Msx1 and BMP4 in fetal mice. Pubmed 2.056E-7 5.652E-5 5.031E-4 8.478E-4 2 5
14 11714677 BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Pubmed 2.056E-7 5.652E-5 5.031E-4 8.478E-4 2 5
15 16112648 Ascorbic acid promotes osteoclastogenesis from embryonic stem cells. Pubmed 2.056E-7 5.652E-5 5.031E-4 8.478E-4 2 5
16 20843830 The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Pubmed 2.272E-7 5.855E-5 5.212E-4 9.367E-4 3 87
17 7589793 Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Pubmed 3.084E-7 6.055E-5 5.390E-4 1.272E-3 2 6
18 19351956 HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Pubmed 3.084E-7 6.055E-5 5.390E-4 1.272E-3 2 6
19 9244299 Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Pubmed 3.084E-7 6.055E-5 5.390E-4 1.272E-3 2 6
20 20224040 Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin. Pubmed 3.084E-7 6.055E-5 5.390E-4 1.272E-3 2 6
21 12631064 Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development. Pubmed 3.084E-7 6.055E-5 5.390E-4 1.272E-3 2 6
22 17881493 Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Pubmed 5.756E-7 1.052E-4 9.366E-4 2.373E-3 2 8
23 23913870 Prickle1 stunts limb growth through alteration of cell polarity and gene expression. Pubmed 7.400E-7 1.052E-4 9.366E-4 3.051E-3 2 9
24 12708796 In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification. Pubmed 7.400E-7 1.052E-4 9.366E-4 3.051E-3 2 9
25 9811582 Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Pubmed 7.400E-7 1.052E-4 9.366E-4 3.051E-3 2 9
26 9463347 Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Pubmed 7.400E-7 1.052E-4 9.366E-4 3.051E-3 2 9
27 9806931 Formation of Rathke's pouch requires dual induction from the diencephalon. Pubmed 7.400E-7 1.052E-4 9.366E-4 3.051E-3 2 9
28 20570969 Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Pubmed 7.400E-7 1.052E-4 9.366E-4 3.051E-3 2 9
29 18514492 Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice. Pubmed 7.400E-7 1.052E-4 9.366E-4 3.051E-3 2 9
30 28323137 Defects in chondrocyte maturation and secondary ossification in mouse knee joint epiphyses due to Snorc deficiency. Pubmed 9.250E-7 1.230E-4 1.095E-3 3.814E-3 2 10
31 18272352 Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog. Pubmed 9.250E-7 1.230E-4 1.095E-3 3.814E-3 2 10
32 8898217 Msx1 controls inductive signaling in mammalian tooth morphogenesis. Pubmed 1.130E-6 1.260E-4 1.121E-3 4.661E-3 2 11
33 18446812 Brachy-syndactyly caused by loss of Sfrp2 function. Pubmed 1.130E-6 1.260E-4 1.121E-3 4.661E-3 2 11
34 21557453 Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling. Pubmed 1.130E-6 1.260E-4 1.121E-3 4.661E-3 2 11
35 10572046 The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Pubmed 1.130E-6 1.260E-4 1.121E-3 4.661E-3 2 11
36 12569124 Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Pubmed 1.130E-6 1.260E-4 1.121E-3 4.661E-3 2 11
37 16956603 Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Pubmed 1.130E-6 1.260E-4 1.121E-3 4.661E-3 2 11
38 10981962 Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Pubmed 1.356E-6 1.364E-4 1.214E-3 5.593E-3 2 12
39 10821773 Hedgehog signals regulate multiple aspects of gastrointestinal development. Pubmed 1.356E-6 1.364E-4 1.214E-3 5.593E-3 2 12
40 23891934 Enhanced BMP signaling prevents degeneration and leads to endochondral ossification of Meckel's cartilage in mice. Pubmed 1.356E-6 1.364E-4 1.214E-3 5.593E-3 2 12
41 19879143 An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry. Pubmed 1.356E-6 1.364E-4 1.214E-3 5.593E-3 2 12
42 16151852 Apoptosis, proliferation and gene expression patterns in mouse developing tongue. Pubmed 1.603E-6 1.537E-4 1.368E-3 6.609E-3 2 13
43 20847311 The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation. Pubmed 1.603E-6 1.537E-4 1.368E-3 6.609E-3 2 13
44 12163410 Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling. Pubmed 1.870E-6 1.606E-4 1.430E-3 7.710E-3 2 14
45 15537544 Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Pubmed 1.870E-6 1.606E-4 1.430E-3 7.710E-3 2 14
46 17481601 Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Pubmed 1.870E-6 1.606E-4 1.430E-3 7.710E-3 2 14
47 15175265 Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation. Pubmed 1.870E-6 1.606E-4 1.430E-3 7.710E-3 2 14
48 27732085 FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice. Pubmed 1.870E-6 1.606E-4 1.430E-3 7.710E-3 2 14
49 16470614 Visceral endoderm function is regulated by quaking and required for vascular development. Pubmed 2.158E-6 1.711E-4 1.523E-3 8.896E-3 2 15
50 22547067 Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2). Pubmed 2.158E-6 1.711E-4 1.523E-3 8.896E-3 2 15
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 451 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ZFP36 ZFP36 interactions 1.912E-4 3.743E-2
2.504E-1
8.623E-2
 2 64
2 int:MARK3 MARK3 interactions 2.288E-4 3.743E-2
2.504E-1
1.032E-1
 2 70
3 int:HDAC7 HDAC7 interactions 4.485E-4 3.743E-2
2.504E-1
2.023E-1
 2 98
4 int:PPM1H PPM1H interactions 4.485E-4 3.743E-2
2.504E-1
2.023E-1
 2 98
5 int:CGN CGN interactions 5.146E-4 3.743E-2
2.504E-1
2.321E-1
 2 105
6 int:MARK2 MARK2 interactions 5.646E-4 3.743E-2
2.504E-1
2.546E-1
 2 110
7 int:GREM1 GREM1 interactions 1.016E-3 3.743E-2
2.504E-1
4.584E-1
 1 3
8 int:GREM2 GREM2 interactions 1.016E-3 3.743E-2
2.504E-1
4.584E-1
 1 3
9 int:CALR CALR interactions 1.074E-3 3.743E-2
2.504E-1
4.844E-1
 2 152
10 int:FXR2 FXR2 interactions 1.131E-3 3.743E-2
2.504E-1
5.100E-1
 2 156
11 int:CBWD6 CBWD6 interactions 1.355E-3 3.743E-2
2.504E-1
6.112E-1
 1 4
12 int:BMPER BMPER interactions 1.355E-3 3.743E-2
2.504E-1
6.112E-1
 1 4
13 int:IHH IHH interactions 1.694E-3 3.743E-2
2.504E-1
7.638E-1
 1 5
14 int:NOG NOG interactions 1.694E-3 3.743E-2
2.504E-1
7.638E-1
 1 5
15 int:HHIP HHIP interactions 1.694E-3 3.743E-2
2.504E-1
7.638E-1
 1 5
16 int:MTRF1L MTRF1L interactions 2.032E-3 3.743E-2
2.504E-1
9.165E-1
 1 6
17 int:SOSTDC1 SOSTDC1 interactions 2.032E-3 3.743E-2
2.504E-1
9.165E-1
 1 6
18 int:CDCA7 CDCA7 interactions 2.370E-3 3.743E-2
2.504E-1
1.000E0
 1 7
19 int:DCLRE1A DCLRE1A interactions 2.370E-3 3.743E-2
2.504E-1
1.000E0
 1 7
20 int:CHI3L1 CHI3L1 interactions 2.370E-3 3.743E-2
2.504E-1
1.000E0
 1 7
21 int:BMP8B BMP8B interactions 2.709E-3 3.743E-2
2.504E-1
1.000E0
 1 8
22 int:PTCH2 PTCH2 interactions 2.709E-3 3.743E-2
2.504E-1
1.000E0
 1 8
23 int:OARD1 OARD1 interactions 2.709E-3 3.743E-2
2.504E-1
1.000E0
 1 8
24 int:CHRDL1 CHRDL1 interactions 2.709E-3 3.743E-2
2.504E-1
1.000E0
 1 8
25 int:CHRDL2 CHRDL2 interactions 2.709E-3 3.743E-2
2.504E-1
1.000E0
 1 8
26 int:KCNK15 KCNK15 interactions 2.709E-3 3.743E-2
2.504E-1
1.000E0
 1 8
27 int:RGMB RGMB interactions 2.709E-3 3.743E-2
2.504E-1
1.000E0
 1 8
28 int:SPRYD3 SPRYD3 interactions 2.709E-3 3.743E-2
2.504E-1
1.000E0
 1 8
29 int:YWHAH YWHAH interactions 2.803E-3 3.743E-2
2.504E-1
1.000E0
 2 247
30 int:TUBG1 TUBG1 interactions 2.893E-3 3.743E-2
2.504E-1
1.000E0
 2 251
31 int:KCNK9 KCNK9 interactions 3.047E-3 3.743E-2
2.504E-1
1.000E0
 1 9
32 int:FGFBP1 FGFBP1 interactions 3.047E-3 3.743E-2
2.504E-1
1.000E0
 1 9
33 int:TPH1 TPH1 interactions 3.047E-3 3.743E-2
2.504E-1
1.000E0
 1 9
34 int:TWSG1 TWSG1 interactions 3.047E-3 3.743E-2
2.504E-1
1.000E0
 1 9
35 int:CHRNA4 CHRNA4 interactions 3.385E-3 3.743E-2
2.504E-1
1.000E0
 1 10
36 int:TLX2 TLX2 interactions 3.385E-3 3.743E-2
2.504E-1
1.000E0
 1 10
37 int:REM1 REM1 interactions 3.385E-3 3.743E-2
2.504E-1
1.000E0
 1 10
38 int:CXCL13 CXCL13 interactions 3.385E-3 3.743E-2
2.504E-1
1.000E0
 1 10
39 int:SRRM2 SRRM2 interactions 3.412E-3 3.743E-2
2.504E-1
1.000E0
 2 273
40 int:ARHGEF28 ARHGEF28 interactions 3.723E-3 3.743E-2
2.504E-1
1.000E0
 1 11
41 int:KCNK3 KCNK3 interactions 3.723E-3 3.743E-2
2.504E-1
1.000E0
 1 11
42 int:RPL6 RPL6 interactions 4.024E-3 3.743E-2
2.504E-1
1.000E0
 2 297
43 int:SPATA13 SPATA13 interactions 4.061E-3 3.743E-2
2.504E-1
1.000E0
 1 12
44 int:MEX3D MEX3D interactions 4.061E-3 3.743E-2
2.504E-1
1.000E0
 1 12
45 int:FAM83G FAM83G interactions 4.061E-3 3.743E-2
2.504E-1
1.000E0
 1 12
46 int:SNTG1 SNTG1 interactions 4.061E-3 3.743E-2
2.504E-1
1.000E0
 1 12
47 int:PF4 PF4 interactions 4.061E-3 3.743E-2
2.504E-1
1.000E0
 1 12
48 int:EML3 EML3 interactions 4.061E-3 3.743E-2
2.504E-1
1.000E0
 1 12
49 int:FST FST interactions 4.399E-3 3.743E-2
2.504E-1
1.000E0
 1 13
50 int:SAMSN1 SAMSN1 interactions 4.399E-3 3.743E-2
2.504E-1
1.000E0
 1 13
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14q22-q23 14q22-q23 3.462E-4 2.077E-3 5.089E-3 2.077E-3 1 2
2 2q33-q35 2q33-q35 8.653E-4 2.596E-3 6.360E-3 5.192E-3 1 5
3 12q13.1 12q13.1 2.248E-3 4.497E-3 1.102E-2 1.349E-2 1 13
4 22q12.3 22q12.3 6.216E-3 9.318E-3 2.283E-2 3.730E-2 1 36
5 4q26 4q26 7.765E-3 9.318E-3 2.283E-2 4.659E-2 1 45
6 1q32.1 1q32.1 1.957E-2 1.957E-2 4.796E-2
1.174E-1
 1 114
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 48 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$HMEF2 Q6 V$HMEF2 Q6 8.833E-4 4.240E-2
1.890E-1
 4.240E-2 2 120

12: Gene Family [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 992 Histone deacetylases, class IIA genenames.org 1.099E-3 2.403E-3 5.487E-3 5.495E-3 1 4
2 542 Endogenous ligands genenames.org 1.647E-3 2.403E-3 5.487E-3 8.233E-3 2 237
3 1053 14-3-3 phospho-serine/phospho-threonine binding proteins genenames.org 1.922E-3 2.403E-3 5.487E-3 9.612E-3 1 7
4 816 Chitinases genenames.org 1.922E-3 2.403E-3 5.487E-3 9.612E-3 1 7
5 455 Bone morphogenetic proteins|Endogenous ligands genenames.org 3.020E-3 3.020E-3 6.895E-3 1.510E-2 1 11

13: Coexpression [Display Chart] 6 input genes in category / 739 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17823238-TableS7a Human EmbryonicStemCell Soh07 27genes A GeneSigDB 1.292E-5 9.545E-3
6.856E-2
 9.545E-3 2 22
2 M2680 Genes up-regulated in HEK293 cells (kidney fibroblasts) expressing constitutively active form of CTNNB1 [Gene ID=1499] gene. MSigDB C6: Oncogenic Signatures (v6.0) 6.555E-5 2.189E-2
1.573E-1
 4.844E-2 2 49
3 15696083-Table1 Human Lung Wang05 64genes GeneSigDB 8.888E-5 2.189E-2
1.573E-1
6.568E-2
 2 57
4 12782598-Table1 Human Ovarian Schwartz03 81genes GeneSigDB 1.584E-4 2.926E-2
2.102E-1
1.170E-1
 2 76
5 16509772-TableS1 Human StemCell Coller06 136genes GeneSigDB 2.124E-4 3.140E-2
2.255E-1
1.570E-1
 2 88
6 M6767 Genes down-regulated in atypical ductal hyperplastic tissues from patients with (ADHC) breast cancer vs those without the cancer (ADH). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.919E-4 3.742E-2
2.688E-1
3.635E-1
 2 134
7 M2769 Genes down-regulated during early stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v6.0) 8.082E-4 3.742E-2
2.688E-1
5.972E-1
 2 172
8 M4288 Genes up-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.845E-4 3.742E-2
2.688E-1
6.536E-1
 2 180
9 18381423-SuppTable1a Human StemCell Riggi08 262genes GeneSigDB 9.041E-4 3.742E-2
2.688E-1
6.681E-1
 2 182
10 M13256 Genes down-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.847E-4 3.742E-2
2.688E-1
7.277E-1
 2 190
11 M9657 Genes down-regulated in CD4 [GeneID=920] T helper cells (60h): Th0 versus TGFB1 and IL6 [GeneID=7040;3569]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.742E-2
2.688E-1
8.056E-1
 2 200
12 M4081 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus those stimulated at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.742E-2
2.688E-1
8.056E-1
 2 200
13 M4809 Genes down-regulated in comparison of B cells versus NKT cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.742E-2
2.688E-1
8.056E-1
 2 200
14 M7650 Genes up-regulated in CD4 [GeneID=920] T cells under specific pathogen free conditions: healthy versus arthritis (KRN model). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.742E-2
2.688E-1
8.056E-1
 2 200
15 M5630 Genes up-regulated in comparison of control thymocytes versus thymocytes treated with dexamethasone [PubChem=5743]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.742E-2
2.688E-1
8.056E-1
 2 200
16 M7524 Genes down-regulated in untreated double positive thymocytes: ELK4 [GeneID=2005] knockout versus ELK1 and ELK4 [GeneID=2002;2005] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.742E-2
2.688E-1
8.056E-1
 2 200
17 M9553 Genes up-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: wildtype versus ID2 [GeneID=3398]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.742E-2
2.688E-1
8.056E-1
 2 200
18 M7280 Genes down-regulated in monocytes pre-treated with Ly294002 [PubChem=3973]: control versus HCMV infection. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.742E-2
2.688E-1
8.056E-1
 2 200
19 M8538 Genes up-regulated in KLRB1 high [GeneID=3820] T cells: CD8A [GeneID=925] versus CD8A CD8B [GeneID=925;926]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.742E-2
2.688E-1
8.056E-1
 2 200
20 M9691 Genes up-regulated in CD4 [GeneID=920] T helper cells (60h): Th0 versus Th17 treated with TGFB1, IL6 [GeneID=7040;3569] and IL-23. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.742E-2
2.688E-1
8.056E-1
 2 200
21 M6432 Genes up-regulated in NKT cells versus B1 B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.742E-2
2.688E-1
8.056E-1
 2 200
22 17823238-TableS4a Mouse EmbryonicStemCell Soh07 224genes A GeneSigDB 1.223E-3 3.742E-2
2.688E-1
9.041E-1
 2 212
23 19726060-Figure4a Human pancreas Farrow09 5genes TDPSvsPanc-1Cells. GeneSigDB 1.296E-3 3.742E-2
2.688E-1
9.578E-1
 1 5
24 M1336 Angiogenic genes up-regulated in hepatocytes after knockout of VHL and HIF2A [GeneID=7428;2034]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.296E-3 3.742E-2
2.688E-1
9.578E-1
 1 5
25 20103679-ST3-C Human Breast Wood10 302genes GeneSigDB 1.305E-3 3.742E-2
2.688E-1
9.642E-1
 2 219
26 17823238-TableS4b Human EmbryonicStemCell Soh07 224genes B GeneSigDB 1.317E-3 3.742E-2
2.688E-1
9.729E-1
 2 220
27 M1295 Stemness-related genes changed in A17 carcinomas (MTC, mesenchymal tumor cells) compared with the mesenchymal stem cells (MSC). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.555E-3 4.104E-2
2.948E-1
1.000E0
 1 6
28 M12751 Genes down-regulated in DLD-1 cells (colon cancer) in response to hypoxia; might not be direct targets of HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.555E-3 4.104E-2
2.948E-1
1.000E0
 1 6
29 M7057 Genes higher expressed in the best 25 mesothelioma survivors compared to the 25 worst ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.814E-3 4.623E-2
3.321E-1
1.000E0
 1 7
Show 24 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 746 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 6 input genes in category / 42 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M7888 MODULE 433 Cytokines and GFs. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.365E-4 2.253E-2
9.750E-2
 2.253E-2 2 61

16: MicroRNA [Display Chart] 6 input genes in category / 271 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-107:PITA hsa-miR-107:PITA TOP PITA 3.205E-6 4.343E-4 2.685E-3 8.686E-4 3 395
2 hsa-miR-103:PITA hsa-miR-103:PITA TOP PITA 3.205E-6 4.343E-4 2.685E-3 8.686E-4 3 395
3 hsa-miR-299-3p:TargetScan hsa-miR-299-3p TargetScan 2.504E-5 1.960E-3 1.211E-2 6.786E-3 2 94
4 hsa-miR-140-5p:Functional MTI Functional MTI miRTarbase 2.892E-5 1.960E-3 1.211E-2 7.838E-3 2 101
5 hsa-miR-4729:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.407E-5 2.189E-3 1.353E-2 1.465E-2 2 138
6 hsa-miR-147:PITA hsa-miR-147:PITA TOP PITA 6.734E-5 2.189E-3 1.353E-2 1.825E-2 2 154
7 hsa-miR-4310:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.179E-5 2.189E-3 1.353E-2 1.946E-2 2 159
8 hsa-miR-7157-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.179E-5 2.189E-3 1.353E-2 1.946E-2 2 159
9 hsa-miR-1276:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.270E-5 2.189E-3 1.353E-2 1.970E-2 2 160
10 ATGCTGC,MIR-103:MSigDB ATGCTGC,MIR-103:MSigDB MSigDB 1.170E-4 2.882E-3 1.782E-2 3.170E-2 2 203
11 ATGCTGC,MIR-107:MSigDB ATGCTGC,MIR-107:MSigDB MSigDB 1.170E-4 2.882E-3 1.782E-2 3.170E-2 2 203
12 hsa-miR-503-5p:TargetScan hsa-miR-503-5p TargetScan 1.288E-4 2.908E-3 1.798E-2 3.490E-2 2 213
13 hsa-miR-107:Functional MTI Functional MTI miRTarbase 2.550E-4 5.316E-3 3.286E-2
6.911E-2
 2 300
14 hsa-miR-6838-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.243E-4 9.969E-3
6.162E-2
1.421E-1
 2 431
15 hsa-miR-103a-3p:Non-Functional MTI Non-Functional MTI miRTarbase 5.788E-4 9.969E-3
6.162E-2
1.569E-1
 2 453
16 hsa-miR-497-5p:Functional MTI Functional MTI miRTarbase 5.967E-4 9.969E-3
6.162E-2
1.617E-1
 2 460
17 hsa-miR-424-5p:Functional MTI Functional MTI miRTarbase 6.253E-4 9.969E-3
6.162E-2
1.695E-1
 2 471
18 hsa-miR-129-5p:PITA hsa-miR-129-5p:PITA TOP PITA 6.682E-4 1.006E-2
6.218E-2
1.811E-1
 2 487
19 hsa-miR-652:PITA hsa-miR-652:PITA TOP PITA 1.494E-3 2.131E-2
1.317E-1
4.049E-1
 1 18
20 hsa-miR-598-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.075E-3 2.648E-2
1.637E-1
5.622E-1
 1 25
21 hsa-miR-181c-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.655E-3 2.648E-2
1.637E-1
7.195E-1
 1 32
22 hsa-miR-708-3p:Functional MTI Functional MTI miRTarbase 3.318E-3 2.648E-2
1.637E-1
8.991E-1
 1 40
23 hsa-miR-1203:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.318E-3 2.648E-2
1.637E-1
8.991E-1
 1 40
24 hsa-miR-4669:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.318E-3 2.648E-2
1.637E-1
8.991E-1
 1 40
25 hsa-miR-3657:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.401E-3 2.648E-2
1.637E-1
9.216E-1
 1 41
26 hsa-miR-7157-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.897E-3 2.648E-2
1.637E-1
1.000E0
 1 47
27 hsa-miR-5008-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.980E-3 2.648E-2
1.637E-1
1.000E0
 1 48
28 hsa-miR-6737-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.980E-3 2.648E-2
1.637E-1
1.000E0
 1 48
29 hsa-miR-1284:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.063E-3 2.648E-2
1.637E-1
1.000E0
 1 49
30 hsa-miR-598:PITA hsa-miR-598:PITA TOP PITA 4.063E-3 2.648E-2
1.637E-1
1.000E0
 1 49
31 hsa-miR-5591-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.063E-3 2.648E-2
1.637E-1
1.000E0
 1 49
32 hsa-miR-152-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 2.648E-2
1.637E-1
1.000E0
 1 50
33 hsa-miR-660-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 2.648E-2
1.637E-1
1.000E0
 1 50
34 hsa-miR-600:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.311E-3 2.648E-2
1.637E-1
1.000E0
 1 52
35 hsa-miR-378j:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.394E-3 2.648E-2
1.637E-1
1.000E0
 1 53
36 hsa-miR-6839-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.394E-3 2.648E-2
1.637E-1
1.000E0
 1 53
37 hsa-miR-26b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 2.648E-2
1.637E-1
1.000E0
 1 56
38 hsa-miR-6824-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 2.648E-2
1.637E-1
1.000E0
 1 56
39 hsa-miR-3935:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 2.648E-2
1.637E-1
1.000E0
 1 56
40 hsa-miR-6764-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.725E-3 2.648E-2
1.637E-1
1.000E0
 1 57
41 hsa-miR-1910-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.890E-3 2.648E-2
1.637E-1
1.000E0
 1 59
42 hsa-miR-6853-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 2.648E-2
1.637E-1
1.000E0
 1 63
43 hsa-miR-4782-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.635E-3 2.648E-2
1.637E-1
1.000E0
 1 68
44 hsa-miR-5706:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.635E-3 2.648E-2
1.637E-1
1.000E0
 1 68
45 hsa-miR-4764-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 2.648E-2
1.637E-1
1.000E0
 1 69
46 hsa-miR-5100:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.965E-3 2.648E-2
1.637E-1
1.000E0
 1 72
47 hsa-miR-7109-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 2.648E-2
1.637E-1
1.000E0
 1 73
48 hsa-miR-648:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.131E-3 2.648E-2
1.637E-1
1.000E0
 1 74
49 hsa-miR-518c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.131E-3 2.648E-2
1.637E-1
1.000E0
 1 74
50 hsa-miR-198:Functional MTI Functional MTI miRTarbase 6.131E-3 2.648E-2
1.637E-1
1.000E0
 1 74
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 2566 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:D006025 Glycosaminoglycans CTD 5.226E-6 6.658E-3
5.611E-2
 1.341E-2 2 14
2 ctd:D016285 Iloprost CTD 9.814E-6 6.658E-3
5.611E-2
 2.518E-2 2 19
3 4097 UP Gelsemine [509-15-9]; Up 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.240E-5 6.658E-3
5.611E-2
 3.181E-2 3 197
4 3551 UP Piperidolate hydrochloride [129-77-1]; Up 200; 11.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.240E-5 6.658E-3
5.611E-2
 3.181E-2 3 197
5 3549 UP Saquinavir mesylate [149845-06-7]; Up 200; 5.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.297E-5 6.658E-3
5.611E-2
 3.329E-2 3 200
6 CID005289285 Reidispongiolide C Stitch 3.547E-5 1.517E-2
1.278E-1
9.101E-2
 3 280
7 ctd:D005944 Glucosamine CTD 4.944E-5 1.739E-2
1.465E-1
1.269E-1
 3 313
8 ctd:C525422 SRT1720 CTD 6.184E-5 1.739E-2
1.465E-1
1.587E-1
 2 47
9 ctd:D002713 Chlorine CTD 8.003E-5 1.739E-2
1.465E-1
2.053E-1
 3 368
10 ctd:C105686 SU 5402 CTD 8.487E-5 1.739E-2
1.465E-1
2.178E-1
 2 55
11 ctd:D010672 Phenytoin CTD 9.655E-5 1.739E-2
1.465E-1
2.477E-1
 3 392
12 ctd:D015056 1-Methyl-3-isobutylxanthine CTD 1.160E-4 1.739E-2
1.465E-1
2.976E-1
 3 417
13 CID000001401 PD173074 Stitch 1.187E-4 1.739E-2
1.465E-1
3.047E-1
 2 65
14 ctd:D016578 Crack Cocaine CTD 1.300E-4 1.739E-2
1.465E-1
3.336E-1
 2 68
15 CID004620597 Bmps Stitch 1.339E-4 1.739E-2
1.465E-1
3.435E-1
 2 69
16 CID000198577 Diacetam 5 Stitch 1.378E-4 1.739E-2
1.465E-1
3.535E-1
 2 70
17 CID005289552 alpha-D-glucose 1-phosphate 6-vanadate Stitch 2.179E-4 1.739E-2
1.465E-1
5.592E-1
 2 88
18 CID005464587 D3273 Stitch 2.487E-4 1.739E-2
1.465E-1
6.381E-1
 2 94
19 DB03935 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid Drug Bank 2.627E-4 1.739E-2
1.465E-1
6.741E-1
 1 1
20 ctd:D006583 Hexadimethrine Bromide CTD 2.627E-4 1.739E-2
1.465E-1
6.741E-1
 1 1
21 CID000078364 bismuth-thiol Stitch 2.627E-4 1.739E-2
1.465E-1
6.741E-1
 1 1
22 ctd:C553471 3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one CTD 2.627E-4 1.739E-2
1.465E-1
6.741E-1
 1 1
23 CID000002072 5-AIQ Stitch 2.627E-4 1.739E-2
1.465E-1
6.741E-1
 1 1
24 ctd:C117757 E 5842 CTD 2.627E-4 1.739E-2
1.465E-1
6.741E-1
 1 1
25 CID000105068 pyridinoline Stitch 2.758E-4 1.739E-2
1.465E-1
7.077E-1
 2 99
26 CID000007833 4-vinylcyclohexene diepoxide Stitch 3.102E-4 1.739E-2
1.465E-1
7.960E-1
 2 105
27 CID000452221 AC1L9Q5W Stitch 3.162E-4 1.739E-2
1.465E-1
8.112E-1
 2 106
28 CID000492400 NVP & EFV Stitch 4.117E-4 1.739E-2
1.465E-1
1.000E0
 2 121
29 ctd:C101044 tyrphostin AG 1478 CTD 4.117E-4 1.739E-2
1.465E-1
1.000E0
 2 121
30 ctd:D001149 Arsenates CTD 4.323E-4 1.739E-2
1.465E-1
1.000E0
 2 124
31 CID000150310 Selara Stitch 4.393E-4 1.739E-2
1.465E-1
1.000E0
 2 125
32 CID000005307 A19413 Stitch 4.823E-4 1.739E-2
1.465E-1
1.000E0
 2 131
33 ctd:C043680 ptaquiloside CTD 4.971E-4 1.739E-2
1.465E-1
1.000E0
 2 133
34 CID000513917 EDTA dianhydride Stitch 5.253E-4 1.739E-2
1.465E-1
1.000E0
 1 2
35 ctd:C545140 6,8-dichloro-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine CTD 5.253E-4 1.739E-2
1.465E-1
1.000E0
 1 2
36 CID001070159 Qbs Stitch 5.253E-4 1.739E-2
1.465E-1
1.000E0
 1 2
37 ctd:D014269 Trifluoroacetic Acid CTD 5.253E-4 1.739E-2
1.465E-1
1.000E0
 1 2
38 CID006327665 diamino selenate Stitch 5.253E-4 1.739E-2
1.465E-1
1.000E0
 1 2
39 CID000133153 sulfanizolone Stitch 5.253E-4 1.739E-2
1.465E-1
1.000E0
 1 2
40 DB04297 7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide Drug Bank 5.253E-4 1.739E-2
1.465E-1
1.000E0
 1 2
41 CID005310997 AGN192093 Stitch 5.253E-4 1.739E-2
1.465E-1
1.000E0
 1 2
42 CID000130586 C6-NBD-PE Stitch 5.253E-4 1.739E-2
1.465E-1
1.000E0
 1 2
43 DB03981 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Drug Bank 5.253E-4 1.739E-2
1.465E-1
1.000E0
 1 2
44 CID000378611 Cu-GHK Stitch 5.253E-4 1.739E-2
1.465E-1
1.000E0
 1 2
45 CID000461663 CC-1069 Stitch 5.253E-4 1.739E-2
1.465E-1
1.000E0
 1 2
46 ctd:C005274 naringin CTD 5.985E-4 1.739E-2
1.465E-1
1.000E0
 2 146
47 ctd:C082182 3,5-diiodothyropropionic acid CTD 7.879E-4 1.739E-2
1.465E-1
1.000E0
 1 3
48 DB00686 Pentosan Polysulfate Drug Bank 7.879E-4 1.739E-2
1.465E-1
1.000E0
 1 3
49 DB00877 Sirolimus Drug Bank 7.879E-4 1.739E-2
1.465E-1
1.000E0
 1 3
50 CID000078701 3-bromopropylamine Stitch 7.879E-4 1.739E-2
1.465E-1
1.000E0
 1 3
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 565 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 3.066E-6 1.732E-3 1.198E-2 1.732E-3 4 349
2 C0010278 Craniosynostosis DisGeNET Curated 1.463E-5 4.134E-3 2.858E-2 8.267E-3 3 148
3 C0342384 Idiopathic hypogonadotropic hypogonadism DisGeNET Curated 5.287E-5 4.808E-3 3.325E-2 2.987E-2 2 31
4 C3536714 Renal dysplasia DisGeNET Curated 8.856E-5 4.808E-3 3.325E-2
5.004E-2
 2 40
5 C0751955 Brain Infarction DisGeNET Curated 1.025E-4 4.808E-3 3.325E-2
5.790E-2
 2 43
6 C0149521 Pancreatitis, Chronic DisGeNET Curated 1.046E-4 4.808E-3 3.325E-2
5.910E-2
 3 286
7 C0019284 Diaphragmatic Hernia DisGeNET Curated 1.279E-4 4.808E-3 3.325E-2
7.226E-2
 2 48
8 C0242383 Age related macular degeneration DisGeNET Curated 1.687E-4 4.808E-3 3.325E-2
9.531E-2
 3 336
9 C0158646 Cleft palate with cleft lip DisGeNET Curated 1.807E-4 4.808E-3 3.325E-2
1.021E-1
 2 57
10 C0152427 Polydactyly DisGeNET Curated 1.807E-4 4.808E-3 3.325E-2
1.021E-1
 2 57
11 C0042373 Vascular Diseases DisGeNET Curated 2.208E-4 4.808E-3 3.325E-2
1.247E-1
 3 368
12 C0039075 Syndactyly DisGeNET Curated 2.887E-4 4.808E-3 3.325E-2
1.631E-1
 2 72
13 C1862158 Terminal symphalangism of hands DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
14 OMIN:611960 ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 7; ASRT7 OMIM 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
15 cv:C1843096 Acrocapitofemoral dysplasia Clinical Variations 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
16 C4021251 Dysplastic femoral heads DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
17 C4025088 Broad metacarpal epiphyses DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
18 C1862157 Proportionate shortening of all digits DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
19 C1843105 Large distal femoral epiphyses DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
20 cv:C2677434 Orofacial cleft 11 Clinical Variations 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
21 C1862159 Short proximal phalanges of halluces DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
22 cv:C1862151 Brachydactyly type A1 Clinical Variations 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
23 C4025079 Thin proximal phalanges with broad epiphyses of the hand DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
24 cv:C2677770 ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 7 Clinical Variations 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
25 C4024473 Radial deviation of the 4th finger DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
26 C1864298 Fibular overgrowth DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
27 C1855091 Short proximal phalanges of thumb DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
28 C1997728 Osteomyelitis due to Staphylococcus aureus DisGeNET BeFree 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
29 C2677770 ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 7 DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
30 OMIN:607778 ACROCAPITOFEMORAL DYSPLASIA; ACFD OMIM 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
31 C1864689 MICROPHTHALMIA, SYNDROMIC 6 (disorder) DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
32 OMIN:607932 MICROPHTHALMIA, SYNDROMIC 6; MCOPS6 OMIM 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
33 C1333987 Hereditary Glomangioma DisGeNET BeFree 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
34 C1860606 Short proximal phalanges DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
35 C1846157 Cone-shaped capital femoral epiphyses DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
36 C1843096 Acrocapitofemoral Dysplasia DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
37 C1334687 Megakaryocytic Neoplasm DisGeNET BeFree 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
38 20081125:Ober YKL-40 levels GWAS 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
39 C1862156 Thin proximal phalanges with broad epiphyses DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
40 OMIN:600625 OROFACIAL CLEFT 11; OFC11 OMIM 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
41 C4024106 Cone-shaped epiphysis of the 1st metacarpal DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
42 C4280377 Abnormality of femoral head development DisGeNET Curated 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
43 cv:C1864689 Microphthalmia syndromic 6 Clinical Variations 3.703E-4 4.808E-3 3.325E-2
2.092E-1
 1 1
44 C0033375 Prolactinoma DisGeNET Curated 3.745E-4 4.808E-3 3.325E-2
2.116E-1
 2 82
45 C0026987 Myelofibrosis DisGeNET Curated 4.510E-4 5.662E-3 3.915E-2
2.548E-1
 2 90
46 C0008924 Cleft Lip DisGeNET Curated 5.130E-4 6.301E-3 4.357E-2
2.898E-1
 2 96
47 C0266617 Congenital anomaly of face DisGeNET Curated 5.565E-4 6.689E-3 4.626E-2
3.144E-1
 2 100
48 C1704436 Peripheral Arterial Diseases DisGeNET Curated 6.017E-4 6.858E-3 4.742E-2
3.400E-1
 2 104
49 C0022408 Arthropathy DisGeNET Curated 7.099E-4 6.858E-3 4.742E-2
4.011E-1
 2 113
50 C0854723 Retinal Dystrophies DisGeNET Curated 7.224E-4 6.858E-3 4.742E-2
4.082E-1
 2 114
Show 45 more annotations