Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc34_53, positive side

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1: GO: Molecular Function [Display Chart] 53 input genes in category / 171 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0015078 proton transmembrane transporter activity 1.000E-14 1.711E-12 9.787E-12 1.711E-12 11 109
2 GO:0051400 BH domain binding 8.156E-14 3.487E-12 1.995E-11 1.395E-11 6 10
3 GO:0008121 ubiquinol-cytochrome-c reductase activity 8.156E-14 3.487E-12 1.995E-11 1.395E-11 6 10
4 GO:0016681 oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor 8.156E-14 3.487E-12 1.995E-11 1.395E-11 6 10
5 GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors 1.790E-13 6.123E-12 3.504E-11 3.062E-11 6 11
6 GO:0070513 death domain binding 1.902E-11 5.421E-10 3.102E-9 3.252E-9 5 9
7 GO:0009055 electron transfer activity 3.565E-11 8.708E-10 4.982E-9 6.095E-9 9 116
8 GO:0051434 BH3 domain binding 5.797E-11 1.239E-9 7.090E-9 9.913E-9 4 4
9 GO:0032813 tumor necrosis factor receptor superfamily binding 5.660E-9 1.075E-7 6.153E-7 9.679E-7 6 50
10 GO:0015077 monovalent inorganic cation transmembrane transporter activity 6.674E-9 1.141E-7 6.530E-7 1.141E-6 11 375
11 GO:0004129 cytochrome-c oxidase activity 1.424E-8 1.874E-7 1.072E-6 2.436E-6 5 28
12 GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor 1.424E-8 1.874E-7 1.072E-6 2.436E-6 5 28
13 GO:0015002 heme-copper terminal oxidase activity 1.424E-8 1.874E-7 1.072E-6 2.436E-6 5 28
14 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1.717E-8 2.098E-7 1.200E-6 2.937E-6 5 29
15 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1.911E-7 2.179E-6 1.247E-5 3.268E-5 5 46
16 GO:0005123 death receptor binding 3.348E-7 3.578E-6 2.047E-5 5.725E-5 4 21
17 GO:0005164 tumor necrosis factor receptor binding 2.232E-6 2.245E-5 1.285E-4 3.817E-4 4 33
18 GO:0031625 ubiquitin protein ligase binding 1.152E-5 1.094E-4 6.261E-4 1.970E-3 7 273
19 GO:0044389 ubiquitin-like protein ligase binding 1.266E-5 1.139E-4 6.518E-4 2.164E-3 7 277
20 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2.383E-5 2.038E-4 1.166E-3 4.075E-3 3 20
21 GO:0016505 peptidase activator activity involved in apoptotic process 3.680E-5 2.997E-4 1.715E-3 6.293E-3 3 23
22 GO:0035877 death effector domain binding 4.732E-5 3.678E-4 2.104E-3 8.091E-3 2 4
23 GO:0005126 cytokine receptor binding 1.632E-4 1.213E-3 6.942E-3 2.791E-2 6 289
24 GO:0016504 peptidase activator activity 2.464E-4 1.755E-3 1.004E-2 4.213E-2 3 43
25 GO:0061134 peptidase regulator activity 4.108E-4 2.810E-3 1.608E-2
7.024E-2
 5 222
26 GO:0051536 iron-sulfur cluster binding 7.975E-4 4.956E-3 2.836E-2
1.364E-1
 3 64
27 GO:0051540 metal cluster binding 7.975E-4 4.956E-3 2.836E-2
1.364E-1
 3 64
28 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process 8.116E-4 4.956E-3 2.836E-2
1.388E-1
 2 15
29 GO:0004175 endopeptidase activity 1.810E-3 1.067E-2
6.106E-2
3.095E-1
 6 457
30 GO:0051537 2 iron, 2 sulfur cluster binding 1.927E-3 1.099E-2
6.286E-2
3.296E-1
 2 23
31 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2.277E-3 1.256E-2
7.187E-2
3.894E-1
 2 25
32 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly 2.840E-3 1.518E-2
8.684E-2
4.857E-1
 1 1
33 GO:0031072 heat shock protein binding 3.396E-3 1.760E-2
1.007E-1
5.807E-1
 3 106
34 GO:0002020 protease binding 4.269E-3 2.147E-2
1.228E-1
7.300E-1
 3 115
35 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway 5.672E-3 2.622E-2
1.500E-1
9.700E-1
 1 2
36 GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity 5.672E-3 2.622E-2
1.500E-1
9.700E-1
 1 2
37 GO:0051424 corticotropin-releasing hormone binding 5.672E-3 2.622E-2
1.500E-1
9.700E-1
 1 2
38 GO:0051539 4 iron, 4 sulfur cluster binding 6.046E-3 2.721E-2
1.557E-1
1.000E0
 2 41
39 GO:0008137 NADH dehydrogenase (ubiquinone) activity 7.562E-3 3.117E-2
1.783E-1
1.000E0
 2 46
40 GO:0003954 NADH dehydrogenase activity 7.562E-3 3.117E-2
1.783E-1
1.000E0
 2 46
41 GO:0050136 NADH dehydrogenase (quinone) activity 7.562E-3 3.117E-2
1.783E-1
1.000E0
 2 46
42 GO:0019903 protein phosphatase binding 7.655E-3 3.117E-2
1.783E-1
1.000E0
 3 142
43 GO:0004461 lactose synthase activity 8.497E-3 3.379E-2
1.933E-1
1.000E0
 1 3
44 GO:0097110 scaffold protein binding 1.068E-2 4.149E-2
2.374E-1
1.000E0
 2 55
45 GO:0089720 caspase binding 1.131E-2 4.299E-2
2.460E-1
1.000E0
 1 4
46 GO:0004869 cysteine-type endopeptidase inhibitor activity 1.182E-2 4.394E-2
2.514E-1
1.000E0
 2 58
47 GO:0005507 copper ion binding 1.261E-2 4.472E-2
2.559E-1
1.000E0
 2 60
48 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1.261E-2 4.472E-2
2.559E-1
1.000E0
 2 60
49 GO:0004396 hexokinase activity 1.412E-2 4.472E-2
2.559E-1
1.000E0
 1 5
50 GO:0019158 mannokinase activity 1.412E-2 4.472E-2
2.559E-1
1.000E0
 1 5
Show 45 more annotations

2: GO: Biological Process [Display Chart] 53 input genes in category / 1568 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:2001235 positive regulation of apoptotic signaling pathway 1.123E-26 1.761E-23 1.397E-22 1.761E-23 20 193
2 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.837E-25 1.441E-22 1.143E-21 2.881E-22 20 221
3 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 4.922E-25 2.325E-22 1.845E-21 7.718E-22 16 93
4 GO:2000116 regulation of cysteine-type endopeptidase activity 5.930E-25 2.325E-22 1.845E-21 9.299E-22 20 234
5 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.490E-24 3.846E-22 3.052E-21 2.336E-21 17 128
6 GO:0008637 apoptotic mitochondrial changes 1.713E-24 3.846E-22 3.052E-21 2.686E-21 17 129
7 GO:0097202 activation of cysteine-type endopeptidase activity 1.717E-24 3.846E-22 3.052E-21 2.692E-21 16 100
8 GO:2001056 positive regulation of cysteine-type endopeptidase activity 5.716E-24 1.120E-21 8.889E-21 8.962E-21 17 138
9 GO:0016485 protein processing 2.755E-23 4.799E-21 3.808E-20 4.319E-20 21 338
10 GO:0010950 positive regulation of endopeptidase activity 3.177E-23 4.981E-21 3.952E-20 4.981E-20 17 152
11 GO:2001233 regulation of apoptotic signaling pathway 4.645E-23 6.621E-21 5.254E-20 7.283E-20 22 409
12 GO:0097191 extrinsic apoptotic signaling pathway 8.482E-23 1.108E-20 8.795E-20 1.330E-19 19 247
13 GO:0010952 positive regulation of peptidase activity 1.213E-22 1.442E-20 1.144E-19 1.902E-19 17 164
14 GO:0031638 zymogen activation 1.287E-22 1.442E-20 1.144E-19 2.018E-19 16 129
15 GO:0051604 protein maturation 1.469E-22 1.536E-20 1.219E-19 2.304E-19 21 366
16 GO:0022900 electron transport chain 4.622E-22 4.529E-20 3.594E-19 7.247E-19 15 107
17 GO:0052548 regulation of endopeptidase activity 2.030E-20 1.873E-18 1.486E-17 3.183E-17 20 393
18 GO:0022904 respiratory electron transport chain 2.326E-20 2.026E-18 1.608E-17 3.647E-17 14 104
19 GO:0052547 regulation of peptidase activity 6.257E-20 4.946E-18 3.925E-17 9.810E-17 20 416
20 GO:0042775 mitochondrial ATP synthesis coupled electron transport 6.309E-20 4.946E-18 3.925E-17 9.892E-17 13 82
21 GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 7.465E-20 5.321E-18 4.222E-17 1.171E-16 13 83
22 GO:0038034 signal transduction in absence of ligand 7.465E-20 5.321E-18 4.222E-17 1.171E-16 13 83
23 GO:0042773 ATP synthesis coupled electron transport 1.039E-19 7.080E-18 5.618E-17 1.628E-16 13 85
24 GO:0046902 regulation of mitochondrial membrane permeability 6.966E-19 4.551E-17 3.612E-16 1.092E-15 12 70
25 GO:0045333 cellular respiration 1.272E-18 7.975E-17 6.328E-16 1.994E-15 15 178
26 GO:0090559 regulation of membrane permeability 2.007E-18 1.210E-16 9.603E-16 3.146E-15 12 76
27 GO:0006119 oxidative phosphorylation 2.764E-18 1.605E-16 1.274E-15 4.334E-15 13 108
28 GO:0097193 intrinsic apoptotic signaling pathway 4.269E-18 2.391E-16 1.897E-15 6.694E-15 17 301
29 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 4.524E-18 2.432E-16 1.929E-15 7.094E-15 13 112
30 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 4.652E-18 2.432E-16 1.929E-15 7.295E-15 10 37
31 GO:0001836 release of cytochrome c from mitochondria 1.231E-17 6.226E-16 4.941E-15 1.930E-14 11 61
32 GO:0006091 generation of precursor metabolites and energy 1.540E-17 7.451E-16 5.912E-15 2.414E-14 18 393
33 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 1.568E-17 7.451E-16 5.912E-15 2.459E-14 8 15
34 GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 4.190E-17 1.932E-15 1.533E-14 6.569E-14 10 45
35 GO:0010821 regulation of mitochondrion organization 4.442E-17 1.990E-15 1.579E-14 6.966E-14 15 225
36 GO:0090199 regulation of release of cytochrome c from mitochondria 5.342E-17 2.327E-15 1.846E-14 8.376E-14 10 46
37 GO:0090200 positive regulation of release of cytochrome c from mitochondria 5.739E-17 2.432E-15 1.930E-14 8.999E-14 9 29
38 GO:0007006 mitochondrial membrane organization 9.361E-17 3.862E-15 3.065E-14 1.468E-13 12 103
39 GO:0046034 ATP metabolic process 1.326E-16 5.333E-15 4.232E-14 2.080E-13 15 242
40 GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 1.597E-16 6.261E-15 4.968E-14 2.504E-13 9 32
41 GO:0051204 protein insertion into mitochondrial membrane 2.191E-16 8.330E-15 6.610E-14 3.436E-13 9 33
42 GO:0045862 positive regulation of proteolysis 2.231E-16 8.330E-15 6.610E-14 3.498E-13 17 381
43 GO:0097345 mitochondrial outer membrane permeabilization 2.518E-16 9.182E-15 7.286E-14 3.948E-13 10 53
44 GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 3.084E-16 1.075E-14 8.526E-14 4.835E-13 10 54
45 GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 3.084E-16 1.075E-14 8.526E-14 4.835E-13 10 54
46 GO:0035794 positive regulation of mitochondrial membrane permeability 4.569E-16 1.535E-14 1.218E-13 7.164E-13 10 56
47 GO:0009205 purine ribonucleoside triphosphate metabolic process 4.600E-16 1.535E-14 1.218E-13 7.213E-13 15 263
48 GO:0009199 ribonucleoside triphosphate metabolic process 6.803E-16 2.222E-14 1.763E-13 1.067E-12 15 270
49 GO:0009144 purine nucleoside triphosphate metabolic process 7.187E-16 2.300E-14 1.825E-13 1.127E-12 15 271
50 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 9.594E-16 3.009E-14 2.387E-13 1.504E-12 10 60
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 53 input genes in category / 115 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070469 respiratory chain 1.696E-19 1.951E-17 1.039E-16 1.951E-17 13 90
2 GO:0005741 mitochondrial outer membrane 2.263E-17 1.301E-15 6.930E-15 2.602E-15 14 171
3 GO:0031968 organelle outer membrane 1.564E-16 5.997E-15 3.194E-14 1.799E-14 14 196
4 GO:0019867 outer membrane 2.565E-16 7.375E-15 3.928E-14 2.950E-14 14 203
5 GO:0070069 cytochrome complex 1.461E-15 3.359E-14 1.789E-13 1.680E-13 8 24
6 GO:0098803 respiratory chain complex 2.471E-15 4.736E-14 2.523E-13 2.842E-13 10 67
7 GO:0005746 mitochondrial respiratory chain 8.125E-15 1.335E-13 7.110E-13 9.344E-13 10 75
8 GO:0045275 respiratory chain complex III 7.182E-14 1.032E-12 5.499E-12 8.260E-12 6 10
9 GO:0044455 mitochondrial membrane part 1.189E-13 1.520E-12 8.094E-12 1.368E-11 12 189
10 GO:0098798 mitochondrial protein complex 9.186E-12 1.056E-10 5.627E-10 1.056E-9 10 149
11 GO:0005750 mitochondrial respiratory chain complex III 1.711E-11 1.789E-10 9.528E-10 1.968E-9 5 9
12 GO:0098800 inner mitochondrial membrane protein complex 2.151E-11 2.061E-10 1.098E-9 2.473E-9 9 112
13 GO:0097136 Bcl-2 family protein complex 5.326E-11 4.711E-10 2.509E-9 6.125E-9 4 4
14 GO:1990204 oxidoreductase complex 2.462E-10 2.022E-9 1.077E-8 2.831E-8 8 97
15 GO:0046930 pore complex 1.583E-7 1.214E-6 6.466E-6 1.821E-5 4 18
16 GO:0097342 ripoptosome 7.049E-7 5.066E-6 2.699E-5 8.106E-5 3 7
17 GO:0031264 death-inducing signaling complex 1.685E-6 1.140E-5 6.072E-5 1.938E-4 3 9
18 GO:0005758 mitochondrial intermembrane space 2.642E-6 1.688E-5 8.991E-5 3.038E-4 5 79
19 GO:0031970 organelle envelope lumen 5.316E-6 3.218E-5 1.714E-4 6.113E-4 5 91
20 GO:0043209 myelin sheath 1.994E-5 1.147E-4 6.108E-4 2.293E-3 6 202
21 GO:0043293 apoptosome 2.272E-5 1.244E-4 6.626E-4 2.612E-3 2 3
22 GO:0031265 CD95 death-inducing signaling complex 1.130E-4 5.906E-4 3.146E-3 1.299E-2 2 6
23 GO:0005751 mitochondrial respiratory chain complex IV 2.697E-4 1.349E-3 7.183E-3 3.102E-2 2 9
24 GO:1902495 transmembrane transporter complex 2.836E-4 1.359E-3 7.237E-3 3.261E-2 6 327
25 GO:1990351 transporter complex 3.125E-4 1.438E-3 7.657E-3 3.594E-2 6 333
26 GO:0045121 membrane raft 3.659E-4 1.558E-3 8.301E-3 4.208E-2 6 343
27 GO:0098857 membrane microdomain 3.659E-4 1.558E-3 8.301E-3 4.208E-2 6 343
28 GO:0045277 respiratory chain complex IV 4.106E-4 1.628E-3 8.672E-3 4.722E-2 2 11
29 GO:0035631 CD40 receptor complex 4.106E-4 1.628E-3 8.672E-3 4.722E-2 2 11
30 GO:0044445 cytosolic part 4.837E-4 1.854E-3 9.877E-3
5.563E-2
 5 235
31 GO:0005759 mitochondrial matrix 1.123E-3 4.166E-3 2.219E-2
1.291E-1
 6 425
32 GO:0097144 BAX complex 2.781E-3 9.405E-3
5.009E-2
3.198E-1
 1 1
33 GO:0097141 BIM-BCL-2 complex 2.781E-3 9.405E-3
5.009E-2
3.198E-1
 1 1
34 GO:0097140 BIM-BCL-xl complex 2.781E-3 9.405E-3
5.009E-2
3.198E-1
 1 1
35 GO:0030690 Noc1p-Noc2p complex 5.554E-3 1.774E-2
9.449E-2
6.387E-1
 1 2
36 GO:0005757 mitochondrial permeability transition pore complex 5.554E-3 1.774E-2
9.449E-2
6.387E-1
 1 2
37 GO:0045271 respiratory chain complex I 6.368E-3 1.878E-2
1.000E-1
7.324E-1
 2 43
38 GO:0030964 NADH dehydrogenase complex 6.368E-3 1.878E-2
1.000E-1
7.324E-1
 2 43
39 GO:0005747 mitochondrial respiratory chain complex I 6.368E-3 1.878E-2
1.000E-1
7.324E-1
 2 43
40 GO:0008287 protein serine/threonine phosphatase complex 8.533E-3 2.393E-2
1.275E-1
9.813E-1
 2 50
41 GO:1903293 phosphatase complex 8.533E-3 2.393E-2
1.275E-1
9.813E-1
 2 50
42 GO:0032592 integral component of mitochondrial membrane 9.897E-3 2.710E-2
1.443E-1
1.000E0
 2 54
43 GO:0098573 intrinsic component of mitochondrial membrane 1.061E-2 2.839E-2
1.512E-1
1.000E0
 2 56
44 GO:0030689 Noc complex 1.108E-2 2.895E-2
1.542E-1
1.000E0
 1 4
45 GO:0070847 core mediator complex 1.657E-2 4.235E-2
2.256E-1
1.000E0
 1 6
Show 40 more annotations

4: Human Phenotype [Display Chart] 17 input genes in category / 876 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0006789 Mitochondrial encephalopathy 4.010E-9 3.513E-6 2.583E-5 3.513E-6 6 42
2 HP:0004309 Ventricular preexcitation 9.807E-8 4.295E-5 3.159E-4 8.591E-5 5 35
3 HP:0001298 Encephalopathy 6.641E-7 1.939E-4 1.426E-3 5.818E-4 9 338
4 HP:0003287 Abnormality of mitochondrial metabolism 3.644E-6 5.687E-4 4.182E-3 3.192E-3 6 129
5 HP:0012103 Abnormality of the mitochondrion 4.169E-6 5.687E-4 4.182E-3 3.652E-3 6 132
6 HP:0000631 Retinal arterial tortuosity 6.345E-6 5.687E-4 4.182E-3 5.558E-3 3 11
7 HP:0007768 Central retinal vessel vascular tortuosity 6.345E-6 5.687E-4 4.182E-3 5.558E-3 3 11
8 HP:0002490 Increased CSF lactate 7.914E-6 5.687E-4 4.182E-3 6.933E-3 5 83
9 HP:0030085 Abnormal CSF lactate level 7.914E-6 5.687E-4 4.182E-3 6.933E-3 5 83
10 HP:0001410 Decreased liver function 7.977E-6 5.687E-4 4.182E-3 6.988E-3 8 333
11 HP:0025155 Abnormality of hepatobiliary system physiology 7.977E-6 5.687E-4 4.182E-3 6.988E-3 8 333
12 HP:0001138 Optic neuropathy 8.397E-6 5.687E-4 4.182E-3 7.356E-3 5 84
13 HP:0003737 Mitochondrial myopathy 8.902E-6 5.687E-4 4.182E-3 7.798E-3 5 85
14 HP:0003800 Muscle abnormality related to mitochondrial dysfunction 1.056E-5 5.687E-4 4.182E-3 9.254E-3 5 88
15 HP:0000576 Centrocecal scotoma 1.095E-5 5.687E-4 4.182E-3 9.591E-3 3 13
16 HP:0001112 Leber optic atrophy 1.095E-5 5.687E-4 4.182E-3 9.591E-3 3 13
17 HP:0002151 Increased serum lactate 1.142E-5 5.687E-4 4.182E-3 1.001E-2 6 157
18 HP:0001941 Acidosis 1.169E-5 5.687E-4 4.182E-3 1.024E-2 9 475
19 HP:0025454 Abnormal CSF metabolite level 1.246E-5 5.745E-4 4.224E-3 1.091E-2 5 91
20 HP:0007325 Generalized dystonia 2.129E-5 8.678E-4 6.381E-3 1.865E-2 3 16
21 HP:0002425 Anarthria 2.129E-5 8.678E-4 6.381E-3 1.865E-2 3 16
22 HP:0002401 Stroke-like episode 2.179E-5 8.678E-4 6.381E-3 1.909E-2 5 102
23 HP:0007924 Slow decrease in visual acuity 2.580E-5 9.040E-4 6.648E-3 2.260E-2 3 17
24 HP:0007763 Retinal telangiectasia 2.580E-5 9.040E-4 6.648E-3 2.260E-2 3 17
25 HP:0200125 Mitochondrial respiratory chain defects 2.580E-5 9.040E-4 6.648E-3 2.260E-2 3 17
26 HP:0008316 Abnormal mitochondria in muscle tissue 3.549E-5 1.188E-3 8.732E-3 3.109E-2 4 55
27 HP:0002083 Migraine without aura 3.660E-5 1.188E-3 8.732E-3 3.206E-2 3 19
28 HP:0005116 Arterial tortuosity 6.630E-5 2.074E-3 1.525E-2
5.808E-2
 3 23
29 HP:0004308 Ventricular arrhythmia 7.315E-5 2.210E-3 1.625E-2
6.408E-2
 5 131
30 HP:0003200 Ragged-red muscle fibers 8.232E-5 2.404E-3 1.767E-2
7.211E-2
 4 68
31 HP:0004948 Vascular tortuosity 9.668E-5 2.732E-3 2.009E-2
8.469E-2
 3 26
32 HP:0003546 Exercise intolerance 1.188E-4 3.252E-3 2.391E-2
1.041E-1
 5 145
33 HP:0002480 Hepatic encephalopathy 1.274E-4 3.382E-3 2.487E-2
1.116E-1
 4 76
34 HP:0003128 Lactic acidosis 1.559E-4 3.878E-3 2.851E-2
1.365E-1
 6 249
35 HP:0002076 Migraine 1.581E-4 3.878E-3 2.851E-2
1.385E-1
 5 154
36 HP:0001639 Hypertrophic cardiomyopathy 1.594E-4 3.878E-3 2.851E-2
1.396E-1
 6 250
37 HP:0000603 Central scotoma 1.820E-4 4.309E-3 3.168E-2
1.594E-1
 3 32
38 HP:0012841 Retinal vascular tortuosity 2.186E-4 5.039E-3 3.705E-2
1.915E-1
 3 34
39 HP:0100653 Optic neuritis 2.385E-4 5.358E-3 3.940E-2
2.090E-1
 3 35
40 HP:0001129 Large central visual field defect 2.551E-4 5.547E-3 4.079E-2
2.235E-1
 2 7
41 HP:0002174 Postural tremor 2.596E-4 5.547E-3 4.079E-2
2.274E-1
 3 36
42 HP:0003689 Multiple mitochondrial DNA deletions 3.054E-4 6.370E-3 4.684E-2
2.675E-1
 3 38
43 HP:0009141 Depletion of mitochondrial DNA in muscle tissue 3.301E-4 6.725E-3 4.945E-2
2.892E-1
 3 39
44 HP:0000580 Pigmentary retinopathy 3.404E-4 6.776E-3 4.983E-2
2.982E-1
 6 287
45 HP:0001665 Abnormality of cardiac conduction 3.953E-4 7.696E-3
5.659E-2
3.463E-1
 6 295
46 HP:0001399 Hepatic failure 4.253E-4 8.099E-3
5.956E-2
3.726E-1
 6 299
47 HP:0001942 Metabolic acidosis 4.887E-4 9.109E-3
6.698E-2
4.281E-1
 5 196
48 HP:0003201 Rhabdomyolysis 5.057E-4 9.175E-3
6.747E-2
4.430E-1
 3 45
49 HP:0000543 Optic disc pallor 5.132E-4 9.175E-3
6.747E-2
4.496E-1
 4 109
50 HP:0000622 Blurred vision 6.123E-4 1.034E-2
7.601E-2
5.364E-1
 3 48
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 40 input genes in category / 1260 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0006043 decreased apoptosis 6.640E-12 4.846E-9 3.739E-8 8.367E-9 13 257
2 MP:0012555 decreased cell death 7.692E-12 4.846E-9 3.739E-8 9.692E-9 13 260
3 MP:0009258 abnormal thymocyte apoptosis 1.015E-10 3.667E-8 2.830E-7 1.278E-7 8 65
4 MP:0008942 abnormal induced cell death 1.164E-10 3.667E-8 2.830E-7 1.467E-7 12 255
5 MP:0006412 abnormal T cell apoptosis 1.646E-10 4.147E-8 3.200E-7 2.074E-7 10 149
6 MP:0003763 abnormal thymus physiology 5.223E-10 1.097E-7 8.463E-7 6.581E-7 9 119
7 MP:0008944 decreased sensitivity to induced cell death 1.590E-9 2.862E-7 2.208E-6 2.003E-6 8 91
8 MP:0006414 decreased T cell apoptosis 1.638E-8 2.333E-6 1.800E-5 2.064E-5 6 45
9 MP:0003207 decreased cellular sensitivity to gamma-irradiation 1.666E-8 2.333E-6 1.800E-5 2.100E-5 5 22
10 MP:0003762 abnormal immune organ physiology 3.265E-8 4.114E-6 3.174E-5 4.114E-5 9 190
11 MP:0009542 decreased thymocyte apoptosis 6.114E-8 7.004E-6 5.404E-5 7.704E-5 5 28
12 MP:0004228 decreased cellular sensitivity to ionizing radiation 1.456E-7 1.529E-5 1.180E-4 1.834E-4 5 33
13 MP:0002145 abnormal T cell differentiation 3.944E-7 3.823E-5 2.950E-4 4.970E-4 11 426
14 MP:0009333 abnormal splenocyte physiology 4.356E-7 3.921E-5 3.025E-4 5.489E-4 6 77
15 MP:0002364 abnormal thymus size 4.750E-7 3.990E-5 3.079E-4 5.985E-4 11 434
16 MP:0002403 abnormal pre-B cell morphology 6.446E-7 4.967E-5 3.833E-4 8.122E-4 7 133
17 MP:0008737 abnormal spleen physiology 6.818E-7 4.967E-5 3.833E-4 8.591E-4 6 83
18 MP:0009340 abnormal splenocyte apoptosis 7.096E-7 4.967E-5 3.833E-4 8.941E-4 4 19
19 MP:0013502 decreased fibroblast apoptosis 1.328E-6 8.807E-5 6.796E-4 1.673E-3 4 22
20 MP:0013561 abnormal endocrine gland physiology 2.120E-6 1.336E-4 1.031E-3 2.672E-3 10 403
21 MP:0000571 interdigital webbing 3.142E-6 1.885E-4 1.455E-3 3.959E-3 4 27
22 MP:0005432 abnormal pro-B cell morphology 3.982E-6 2.280E-4 1.760E-3 5.017E-3 6 112
23 MP:0009341 decreased splenocyte apoptosis 4.414E-6 2.418E-4 1.866E-3 5.562E-3 3 9
24 MP:0013500 abnormal fibroblast apoptosis 5.793E-6 3.041E-4 2.347E-3 7.299E-3 5 68
25 MP:0000715 decreased thymocyte number 6.086E-6 3.048E-4 2.352E-3 7.669E-3 7 186
26 MP:0008206 increased B-2 B cell number 6.289E-6 3.048E-4 2.352E-3 7.925E-3 3 10
27 MP:0003132 increased pre-B cell number 9.168E-6 4.278E-4 3.301E-3 1.155E-2 4 35
28 MP:0008478 increased spleen white pulp amount 1.029E-5 4.628E-4 3.571E-3 1.296E-2 4 36
29 MP:0005238 increased brain size 1.141E-5 4.817E-4 3.717E-3 1.437E-2 5 78
30 MP:0012091 increased midbrain size 1.147E-5 4.817E-4 3.717E-3 1.445E-2 3 12
31 MP:0010955 abnormal respiratory electron transport chain 1.547E-5 6.286E-4 4.851E-3 1.949E-2 5 83
32 MP:0010954 abnormal cellular respiration 2.391E-5 9.415E-4 7.265E-3 3.013E-2 6 153
33 MP:0002339 abnormal lymph node morphology 2.823E-5 1.063E-3 8.202E-3 3.558E-2 9 428
34 MP:0002408 abnormal double-positive T cell morphology 2.868E-5 1.063E-3 8.202E-3 3.614E-2 7 236
35 MP:0000938 motor neuron degeneration 3.286E-5 1.183E-3 9.128E-3 4.140E-2 4 48
36 MP:0001025 abnormal sympathetic neuron morphology 3.498E-5 1.224E-3 9.446E-3 4.407E-2 3 17
37 MP:0000702 enlarged lymph nodes 3.742E-5 1.274E-3 9.833E-3 4.715E-2 7 246
38 MP:0002144 abnormal B cell differentiation 4.411E-5 1.446E-3 1.116E-2
5.558E-2
 8 347
39 MP:0013664 abnormal immature B cell number 4.476E-5 1.446E-3 1.116E-2
5.640E-2
 6 171
40 MP:0008209 decreased pre-B cell number 5.059E-5 1.594E-3 1.230E-2
6.375E-2
 5 106
41 MP:0005022 abnormal immature B cell morphology 5.602E-5 1.722E-3 1.328E-2
7.059E-2
 6 178
42 MP:0000706 small thymus 6.434E-5 1.930E-3 1.489E-2
8.107E-2
 8 366
43 MP:0005017 decreased B cell number 7.384E-5 2.164E-3 1.670E-2
9.304E-2
 9 484
44 MP:0000771 abnormal brain size 7.778E-5 2.227E-3 1.719E-2
9.800E-2
 8 376
45 MP:0000898 midbrain hyperplasia 8.687E-5 2.384E-3 1.840E-2
1.095E-1
 2 4
46 MP:0006036 abnormal mitochondrial physiology 8.783E-5 2.384E-3 1.840E-2
1.107E-1
 6 193
47 MP:0008211 decreased mature B cell number 8.892E-5 2.384E-3 1.840E-2
1.120E-1
 7 282
48 MP:0005092 decreased double-positive T cell number 9.565E-5 2.481E-3 1.914E-2
1.205E-1
 6 196
49 MP:0008214 increased immature B cell number 9.648E-5 2.481E-3 1.914E-2
1.216E-1
 4 63
50 MP:0000564 syndactyly 1.068E-4 2.692E-3 2.077E-2
1.346E-1
 5 124
Show 45 more annotations

6: Domain [Display Chart] 53 input genes in category / 312 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS01259 BH3 PROSITE 4.201E-28 1.311E-25 8.286E-25 1.311E-25 12 17
2 IPR020728 Bcl2 BH3 motif CS InterPro 7.663E-18 1.195E-15 7.558E-15 2.391E-15 7 8
3 IPR026298 Blc2 fam InterPro 3.141E-16 2.450E-14 1.549E-13 9.799E-14 7 11
4 PS01080 BH1 PROSITE 3.141E-16 2.450E-14 1.549E-13 9.799E-14 7 11
5 PF00452 Bcl-2 Pfam 7.522E-16 4.694E-14 2.967E-13 2.347E-13 7 12
6 PS50062 BCL2 FAMILY PROSITE 1.626E-15 6.342E-14 4.009E-13 5.074E-13 7 13
7 PS01258 BH2 PROSITE 1.626E-15 6.342E-14 4.009E-13 5.074E-13 7 13
8 IPR002475 Bcl2-like InterPro 1.626E-15 6.342E-14 4.009E-13 5.074E-13 7 13
9 IPR020717 Bcl2 BH1 motif CS InterPro 1.067E-14 3.328E-13 2.104E-12 3.328E-12 6 8
10 IPR020726 Bcl2 BH2 motif CS InterPro 1.067E-14 3.328E-13 2.104E-12 3.328E-12 6 8
11 IPR003093 Bcl2 BH4 InterPro 2.847E-10 6.833E-9 4.320E-8 8.883E-8 4 5
12 PS01260 BH4 1 PROSITE 2.847E-10 6.833E-9 4.320E-8 8.883E-8 4 5
13 PS50063 BH4 2 PROSITE 2.847E-10 6.833E-9 4.320E-8 8.883E-8 4 5
14 IPR020731 Bcl2 BH4 motif CS InterPro 2.138E-8 4.169E-7 2.635E-6 6.670E-6 3 3
15 PF02180 BH4 Pfam 2.138E-8 4.169E-7 2.635E-6 6.670E-6 3 3
16 SM00265 BH4 SMART 2.138E-8 4.169E-7 2.635E-6 6.670E-6 3 3
17 1.10.533.10 - Gene3D 2.418E-7 4.437E-6 2.805E-5 7.543E-5 6 93
18 IPR011029 DEATH-like dom InterPro 3.509E-7 6.082E-6 3.845E-5 1.095E-4 6 99
19 IPR013288 Cyt c oxidase su4 InterPro 7.852E-6 1.065E-4 6.734E-4 2.450E-3 2 2
20 1.10.442.10 - Gene3D 7.852E-6 1.065E-4 6.734E-4 2.450E-3 2 2
21 PF02936 COX4 Pfam 7.852E-6 1.065E-4 6.734E-4 2.450E-3 2 2
22 IPR004725 Bcl2/BclX InterPro 7.852E-6 1.065E-4 6.734E-4 2.450E-3 2 2
23 IPR004203 Cyt c oxidase su4 fam InterPro 7.852E-6 1.065E-4 6.734E-4 2.450E-3 2 2
24 PF00619 CARD Pfam 6.661E-5 8.660E-4 5.475E-3 2.078E-2 3 28
25 IPR001315 CARD InterPro 9.086E-5 1.134E-3 7.168E-3 2.835E-2 3 31
26 PS50209 CARD PROSITE 1.098E-4 1.307E-3 8.264E-3 3.427E-2 3 33
27 IPR011237 Pept M16 dom InterPro 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
28 3.30.830.10 - Gene3D 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
29 IPR011249 Metalloenz LuxS/M16 InterPro 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
30 PF00675 Peptidase M16 Pfam 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
31 SM00031 DED SMART 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
32 PS00143 INSULINASE PROSITE 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
33 PF05193 Peptidase M16 C Pfam 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
34 IPR001431 Pept M16 Zn BS InterPro 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
35 PF01335 DED Pfam 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
36 PS50168 DED PROSITE 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
37 IPR007863 Peptidase M16 C InterPro 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
38 IPR001875 DED dom InterPro 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
39 IPR011765 Pept M16 N InterPro 1.634E-4 1.307E-3 8.264E-3
5.098E-2
 2 7
40 PS01121 CASPASE HIS PROSITE 4.249E-4 3.314E-3 2.095E-2
1.326E-1
 2 11
41 IPR002138 Pept C14 p10 InterPro 5.089E-4 3.529E-3 2.231E-2
1.588E-1
 2 12
42 IPR033139 Caspase cys AS InterPro 5.089E-4 3.529E-3 2.231E-2
1.588E-1
 2 12
43 IPR016129 Caspase his AS InterPro 5.089E-4 3.529E-3 2.231E-2
1.588E-1
 2 12
44 PS01122 CASPASE CYS PROSITE 5.089E-4 3.529E-3 2.231E-2
1.588E-1
 2 12
45 PS50207 CASPASE P10 PROSITE 5.089E-4 3.529E-3 2.231E-2
1.588E-1
 2 12
46 SM00115 CASc SMART 6.004E-4 3.985E-3 2.520E-2
1.873E-1
 2 13
47 IPR015917 Pept C14A InterPro 6.004E-4 3.985E-3 2.520E-2
1.873E-1
 2 13
48 3.40.50.1460 - Gene3D 6.992E-4 4.277E-3 2.704E-2
2.181E-1
 2 14
49 IPR029030 Caspase-like dom InterPro 6.992E-4 4.277E-3 2.704E-2
2.181E-1
 2 14
50 IPR001309 Pept C14 p20 InterPro 6.992E-4 4.277E-3 2.704E-2
2.181E-1
 2 14
Show 45 more annotations

7: Pathway [Display Chart] 51 input genes in category / 384 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PW:0000104 intrinsic apoptotic Pathway Ontology 6.442E-35 2.474E-32 1.615E-31 2.474E-32 17 29
2 83060 Apoptosis BioSystems: KEGG 2.395E-32 4.599E-30 3.003E-29 9.198E-30 23 138
3 1384747 Apoptosis - multiple species BioSystems: KEGG 5.073E-31 6.494E-29 4.240E-28 1.948E-28 16 33
4 1270268 Intrinsic Pathway for Apoptosis BioSystems: REACTOME 1.760E-28 1.689E-26 1.103E-25 6.757E-26 16 44
5 P00006 Apoptosis signaling pathway PantherDB 1.519E-27 1.166E-25 7.615E-25 5.831E-25 19 102
6 83097 Alzheimer's disease BioSystems: KEGG 1.792E-26 1.147E-24 7.486E-24 6.879E-24 21 171
7 83100 Huntington's disease BioSystems: KEGG 2.515E-25 1.380E-23 9.007E-23 9.657E-23 21 193
8 83098 Parkinson's disease BioSystems: KEGG 1.253E-24 6.014E-23 3.927E-22 4.811E-22 19 142
9 1270262 Apoptosis BioSystems: REACTOME 1.415E-24 6.038E-23 3.942E-22 5.434E-22 20 174
10 1270261 Programmed Cell Death BioSystems: REACTOME 2.018E-24 7.748E-23 5.058E-22 7.748E-22 20 177
11 862188 Non-alcoholic fatty liver disease (NAFLD) BioSystems: KEGG 3.269E-24 1.141E-22 7.450E-22 1.255E-21 19 149
12 M16257 Role of Mitochondria in Apoptotic Signaling MSigDB C2 BIOCARTA (v6.0) 5.870E-22 1.878E-20 1.226E-19 2.254E-19 11 21
13 1404797 Platinum drug resistance BioSystems: KEGG 1.657E-20 4.893E-19 3.195E-18 6.361E-18 14 73
14 M13096 Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. MSigDB C2 BIOCARTA (v6.0) 3.359E-20 9.212E-19 6.015E-18 1.290E-17 9 12
15 82942 Oxidative phosphorylation BioSystems: KEGG 2.765E-18 6.805E-17 4.443E-16 1.062E-15 15 133
16 1270128 Respiratory electron transport BioSystems: REACTOME 2.835E-18 6.805E-17 4.443E-16 1.089E-15 14 103
17 M14971 Induction of apoptosis through DR3 and DR4/5 Death Receptors MSigDB C2 BIOCARTA (v6.0) 4.493E-17 1.015E-15 6.626E-15 1.725E-14 10 33
18 1270127 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. BioSystems: REACTOME 5.324E-17 1.136E-15 7.416E-15 2.045E-14 14 126
19 137974 Caspase cascade in apoptosis BioSystems: Pathway Interaction Database 5.706E-17 1.153E-15 7.530E-15 2.191E-14 11 50
20 93344 Cardiac muscle contraction BioSystems: KEGG 1.976E-16 3.795E-15 2.478E-14 7.590E-14 12 78
21 1270276 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BioSystems: REACTOME 4.510E-16 8.247E-15 5.385E-14 1.732E-13 7 9
22 1270121 The citric acid (TCA) cycle and respiratory electron transport BioSystems: REACTOME 4.133E-15 7.214E-14 4.710E-13 1.587E-12 14 171
23 137995 HIV-1 Nef: Negative effector of Fas and TNF-alpha BioSystems: Pathway Interaction Database 1.005E-14 1.678E-13 1.096E-12 3.859E-12 9 35
24 M3873 Apoptotic Signaling in Response to DNA Damage MSigDB C2 BIOCARTA (v6.0) 1.365E-14 2.185E-13 1.426E-12 5.243E-12 8 22
25 M13968 HIV-I Nef: negative effector of Fas and TNF MSigDB C2 BIOCARTA (v6.0) 2.349E-14 3.609E-13 2.356E-12 9.022E-12 10 58
26 M19943 Ceramide Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 2.052E-12 3.031E-11 1.979E-10 7.881E-10 7 22
27 138023 Ceramide signaling pathway BioSystems: Pathway Interaction Database 7.072E-12 1.006E-10 6.567E-10 2.716E-9 8 44
28 PW:0000009 programmed cell death Pathway Ontology 1.697E-11 2.327E-10 1.519E-9 6.515E-9 6 15
29 1270280 Apoptotic factor-mediated response BioSystems: REACTOME 1.968E-11 2.606E-10 1.702E-9 7.559E-9 5 7
30 83099 Amyotrophic lateral sclerosis (ALS) BioSystems: KEGG 2.487E-11 3.183E-10 2.078E-9 9.548E-9 8 51
31 83055 p53 signaling pathway BioSystems: KEGG 3.089E-10 3.826E-9 2.498E-8 1.186E-7 8 69
32 M17902 Caspase Cascade in Apoptosis MSigDB C2 BIOCARTA (v6.0) 3.338E-10 4.006E-9 2.615E-8 1.282E-7 6 23
33 MAP00190 Oxidative phosphorylation MAP00190 Oxidative phosphorylation GenMAPP 4.307E-10 5.012E-9 3.273E-8 1.654E-7 7 44
34 M15513 D4-GDI Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.184E-9 1.337E-8 8.733E-8 4.547E-7 5 13
35 1270263 Caspase activation via extrinsic apoptotic signalling pathway BioSystems: REACTOME 1.227E-9 1.346E-8 8.787E-8 4.710E-7 6 28
36 PW:0000034 oxidative phosphorylation Pathway Ontology 1.467E-9 1.565E-8 1.022E-7 5.633E-7 7 52
37 1270300 Regulation of necroptotic cell death BioSystems: REACTOME 1.836E-9 1.906E-8 1.244E-7 7.052E-7 5 14
38 213780 Tuberculosis BioSystems: KEGG 2.252E-9 2.276E-8 1.486E-7 8.648E-7 10 179
39 1270270 Activation of BH3-only proteins BioSystems: REACTOME 2.375E-9 2.339E-8 1.527E-7 9.120E-7 6 31
40 137939 Direct p53 effectors BioSystems: Pathway Interaction Database 2.686E-9 2.578E-8 1.683E-7 1.031E-6 9 132
41 1270299 RIPK1-mediated regulated necrosis BioSystems: REACTOME 3.982E-9 3.641E-8 2.377E-7 1.529E-6 5 16
42 1270298 Regulated Necrosis BioSystems: REACTOME 3.982E-9 3.641E-8 2.377E-7 1.529E-6 5 16
43 138019 p75(NTR)-mediated signaling BioSystems: Pathway Interaction Database 4.652E-9 4.154E-8 2.712E-7 1.786E-6 7 61
44 M8873 Fas Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 7.332E-9 6.399E-8 4.178E-7 2.815E-6 7 65
45 M7997 Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. MSigDB C2 BIOCARTA (v6.0) 1.050E-8 8.963E-8 5.852E-7 4.033E-6 5 19
46 83118 Small cell lung cancer BioSystems: KEGG 4.497E-8 3.730E-7 2.435E-6 1.727E-5 7 84
47 83105 Pathways in cancer BioSystems: KEGG 4.566E-8 3.730E-7 2.435E-6 1.753E-5 12 395
48 137920 TRAIL signaling pathway BioSystems: Pathway Interaction Database 4.711E-8 3.769E-7 2.461E-6 1.809E-5 5 25
49 1269644 Death Receptor Signalling BioSystems: REACTOME 4.832E-8 3.787E-7 2.473E-6 1.856E-5 6 50
50 1270282 Formation of apoptosome BioSystems: REACTOME 6.476E-8 4.974E-7 3.248E-6 2.487E-5 3 3
Show 45 more annotations

8: Pubmed [Display Chart] 53 input genes in category / 12295 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17289999 Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Pubmed 9.403E-31 1.156E-26 1.155E-25 1.156E-26 11 13
2 18309324 No death without life: vital functions of apoptotic effectors. Pubmed 1.777E-29 1.092E-25 1.092E-24 2.185E-25 12 23
3 16697956 Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Pubmed 3.058E-27 1.253E-23 1.253E-22 3.760E-23 10 13
4 20855536 Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. Pubmed 1.084E-26 3.331E-23 3.329E-22 1.332E-22 12 35
5 15694340 Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Pubmed 3.205E-26 7.880E-23 7.876E-22 3.940E-22 10 15
6 15637055 Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells. Pubmed 7.101E-23 1.247E-19 1.247E-18 8.731E-19 8 9
7 11980919 Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. Pubmed 7.101E-23 1.247E-19 1.247E-18 8.731E-19 8 9
8 15721256 BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Pubmed 3.547E-22 5.451E-19 5.448E-18 4.361E-18 8 10
9 21041309 BH3 domains other than Bim and Bid can directly activate Bax/Bak. Pubmed 1.299E-21 1.597E-18 1.596E-17 1.597E-17 8 11
10 9916985 Bcl-2 family proteins. Pubmed 1.299E-21 1.597E-18 1.596E-17 1.597E-17 8 11
11 19074266 Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Pubmed 6.557E-21 6.718E-18 6.714E-17 8.062E-17 7 7
12 21148306 The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. Pubmed 6.557E-21 6.718E-18 6.714E-17 8.062E-17 7 7
13 16227588 Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Pubmed 5.240E-20 4.956E-17 4.953E-16 6.443E-16 7 8
14 10837489 MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. Pubmed 2.356E-19 2.069E-16 2.067E-15 2.896E-15 7 9
15 24038028 Impact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway on the outcome of childhood acute lymphoblastic leukemia. Pubmed 2.155E-18 1.766E-15 1.765E-14 2.649E-14 7 11
16 20959405 The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia. Pubmed 3.155E-18 2.424E-15 2.423E-14 3.879E-14 9 41
17 25565426 BH3-only proteins: a 20-year stock-take. Pubmed 5.328E-18 2.848E-15 2.846E-14 6.550E-14 6 6
18 15574335 The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. Pubmed 5.328E-18 2.848E-15 2.846E-14 6.550E-14 6 6
19 9988219 Cell death in development. Pubmed 5.328E-18 2.848E-15 2.846E-14 6.550E-14 6 6
20 22036586 A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Pubmed 5.328E-18 2.848E-15 2.846E-14 6.550E-14 6 6
21 15901672 Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Pubmed 5.328E-18 2.848E-15 2.846E-14 6.550E-14 6 6
22 21199865 Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. Pubmed 5.328E-18 2.848E-15 2.846E-14 6.550E-14 6 6
23 26344567 An interconnected hierarchical model of cell death regulation by the BCL-2 family. Pubmed 5.328E-18 2.848E-15 2.846E-14 6.550E-14 6 6
24 10377054 Expression of caspase and BCL-2 apoptotic family members in mouse preimplantation embryos. Pubmed 1.118E-17 5.728E-15 5.725E-14 1.375E-13 7 13
25 17927446 Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. Pubmed 3.725E-17 1.579E-14 1.578E-13 4.580E-13 6 7
26 11483855 Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis. Pubmed 3.725E-17 1.579E-14 1.578E-13 4.580E-13 6 7
27 9463381 The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. Pubmed 3.725E-17 1.579E-14 1.578E-13 4.580E-13 6 7
28 23055042 Human Bop is a novel BH3-only member of the Bcl-2 protein family. Pubmed 3.725E-17 1.579E-14 1.578E-13 4.580E-13 6 7
29 10894153 Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Pubmed 3.725E-17 1.579E-14 1.578E-13 4.580E-13 6 7
30 10618441 Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Pubmed 7.430E-17 3.045E-14 3.043E-13 9.136E-13 7 16
31 19573080 Common genetic variants in candidate genes and risk of familial lymphoid malignancies. Pubmed 1.067E-16 4.233E-14 4.231E-13 1.312E-12 11 145
32 11146504 Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis. Pubmed 1.489E-16 5.376E-14 5.373E-13 1.830E-12 6 8
33 21613222 Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site. Pubmed 1.489E-16 5.376E-14 5.373E-13 1.830E-12 6 8
34 26949185 BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation. Pubmed 1.489E-16 5.376E-14 5.373E-13 1.830E-12 6 8
35 14651853 Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Pubmed 1.531E-16 5.376E-14 5.373E-13 1.882E-12 15 494
36 19336552 Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. Pubmed 5.014E-16 1.712E-13 1.711E-12 6.164E-12 7 20
37 24344204 TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. Pubmed 5.468E-16 1.817E-13 1.816E-12 6.723E-12 10 112
38 19141860 Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia. Pubmed 5.874E-16 1.901E-13 1.899E-12 7.222E-12 8 40
39 12819136 Comparative analysis of apoptosis and inflammation genes of mice and humans. Pubmed 6.500E-16 2.049E-13 2.048E-12 7.992E-12 9 71
40 19064571 Polymorphisms in mitochondrial genes and prostate cancer risk. Pubmed 1.092E-15 3.341E-13 3.339E-12 1.342E-11 9 75
41 16509771 IAN family critically regulates survival and development of T lymphocytes. Pubmed 1.114E-15 3.341E-13 3.339E-12 1.370E-11 6 10
42 22516262 Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency. Pubmed 4.238E-15 8.143E-13 8.138E-12 5.211E-11 5 5
43 23443079 Ginsenoside Rh2 induces human hepatoma cell apoptosisvia bax/bak triggered cytochrome C release and caspase-9/caspase-8 activation. Pubmed 4.238E-15 8.143E-13 8.138E-12 5.211E-11 5 5
44 9843949 Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Pubmed 4.238E-15 8.143E-13 8.138E-12 5.211E-11 5 5
45 17097560 Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Pubmed 4.238E-15 8.143E-13 8.138E-12 5.211E-11 5 5
46 21127253 BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Pubmed 4.238E-15 8.143E-13 8.138E-12 5.211E-11 5 5
47 21367852 BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets. Pubmed 4.238E-15 8.143E-13 8.138E-12 5.211E-11 5 5
48 16705087 Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Pubmed 4.238E-15 8.143E-13 8.138E-12 5.211E-11 5 5
49 20836993 Anti-apoptotic Bcl-2 fails to form efficient complexes with pro-apoptotic Bak to protect from Celecoxib-induced apoptosis. Pubmed 4.238E-15 8.143E-13 8.138E-12 5.211E-11 5 5
50 8918887 BID: a novel BH3 domain-only death agonist. Pubmed 4.238E-15 8.143E-13 8.138E-12 5.211E-11 5 5
Show 45 more annotations

9: Interaction [Display Chart] 53 input genes in category / 1968 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:BAX BAX interactions 2.749E-26 5.410E-23 4.416E-22 5.410E-23 17 98
2 int:BCL2L1 BCL2L1 interactions 1.394E-20 1.371E-17 1.119E-16 2.743E-17 16 163
3 int:BCL2 BCL2 interactions 9.750E-19 6.396E-16 5.220E-15 1.919E-15 14 128
4 int:MCL1 MCL1 interactions 4.328E-18 2.129E-15 1.738E-14 8.517E-15 12 77
5 int:CASP8 CASP8 interactions 1.506E-16 5.580E-14 4.554E-13 2.965E-13 14 182
6 int:BCL2L10 BCL2L10 interactions 1.701E-16 5.580E-14 4.554E-13 3.348E-13 7 10
7 int:BCL2A1 BCL2A1 interactions 4.549E-16 1.279E-13 1.044E-12 8.952E-13 8 20
8 int:CYCS CYCS interactions 2.667E-15 6.561E-13 5.355E-12 5.248E-12 10 63
9 int:BID BID interactions 3.719E-15 8.132E-13 6.638E-12 7.319E-12 10 65
10 int:BCL2L2 BCL2L2 interactions 1.519E-14 2.989E-12 2.439E-11 2.989E-11 8 29
11 int:UQCRB UQCRB interactions 1.935E-14 3.462E-12 2.826E-11 3.809E-11 10 76
12 int:CASP9 CASP9 interactions 7.623E-14 1.244E-11 1.015E-10 1.500E-10 9 57
13 int:BAK1 BAK1 interactions 8.215E-14 1.244E-11 1.015E-10 1.617E-10 8 35
14 int:VDAC1 VDAC1 interactions 9.477E-14 1.332E-11 1.087E-10 1.865E-10 14 289
15 int:HRK HRK interactions 1.118E-13 1.467E-11 1.198E-10 2.201E-10 6 10
16 int:CASP3 CASP3 interactions 2.039E-13 2.508E-11 2.047E-10 4.012E-10 12 184
17 int:GIMAP5 GIMAP5 interactions 9.077E-13 1.051E-10 8.577E-10 1.786E-9 6 13
18 int:BBC3 BBC3 interactions 4.207E-12 4.600E-10 3.754E-9 8.279E-9 6 16
19 int:BIRC3 BIRC3 interactions 1.918E-11 1.987E-9 1.621E-8 3.774E-8 9 103
20 int:XIAP XIAP interactions 3.826E-11 3.765E-9 3.073E-8 7.530E-8 10 160
21 int:CASP10 CASP10 interactions 6.991E-11 6.551E-9 5.347E-8 1.376E-7 7 46
22 int:NDUFA12 NDUFA12 interactions 7.424E-11 6.641E-9 5.421E-8 1.461E-7 8 78
23 int:CFLAR CFLAR interactions 1.495E-10 1.279E-8 1.044E-7 2.942E-7 7 51
24 int:BAD BAD interactions 3.821E-10 3.133E-8 2.557E-7 7.520E-7 7 58
25 int:BCL2L11 BCL2L11 interactions 5.507E-10 4.335E-8 3.538E-7 1.084E-6 7 61
26 int:APAF1 APAF1 interactions 6.781E-10 5.133E-8 4.190E-7 1.335E-6 6 34
27 int:PMAIP1 PMAIP1 interactions 1.193E-9 8.699E-8 7.100E-7 2.349E-6 5 17
28 int:NDUFA9 NDUFA9 interactions 1.722E-9 1.210E-7 9.880E-7 3.389E-6 8 115
29 int:CASP2 CASP2 interactions 2.597E-9 1.763E-7 1.439E-6 5.111E-6 6 42
30 int:C15orf48 C15orf48 interactions 2.759E-9 1.810E-7 1.478E-6 5.431E-6 8 122
31 int:NDUFA11 NDUFA11 interactions 4.005E-9 2.543E-7 2.075E-6 7.882E-6 6 45
32 int:NDUFS4 NDUFS4 interactions 4.574E-9 2.813E-7 2.296E-6 9.002E-6 7 82
33 int:BNC1 BNC1 interactions 4.966E-9 2.962E-7 2.417E-6 9.774E-6 4 8
34 int:CYC1 CYC1 interactions 5.898E-9 3.414E-7 2.787E-6 1.161E-5 7 85
35 int:RIPK1 RIPK1 interactions 8.827E-9 4.963E-7 4.051E-6 1.737E-5 7 90
36 int:BIRC2 BIRC2 interactions 1.341E-8 7.333E-7 5.986E-6 2.640E-5 8 149
37 int:UQCRC2 UQCRC2 interactions 2.022E-8 1.075E-6 8.777E-6 3.979E-5 8 157
38 int:MT-CYB MT-CYB interactions 2.326E-8 1.204E-6 9.831E-6 4.577E-5 4 11
39 int:MT-CO2 MT-CO2 interactions 2.633E-8 1.328E-6 1.084E-5 5.181E-5 6 61
40 int:UQCRC1 UQCRC1 interactions 2.908E-8 1.431E-6 1.168E-5 5.723E-5 6 62
41 int:COX4I1 COX4I1 interactions 3.207E-8 1.539E-6 1.256E-5 6.311E-5 6 63
42 int:NDUFS3 NDUFS3 interactions 3.762E-8 1.763E-6 1.439E-5 7.403E-5 8 170
43 int:MRPL58 MRPL58 interactions 5.341E-8 2.444E-6 1.995E-5 1.051E-4 9 252
44 int:CRYAB CRYAB interactions 5.510E-8 2.464E-6 2.011E-5 1.084E-4 7 117
45 int:VAPA VAPA interactions 7.954E-8 3.478E-6 2.839E-5 1.565E-4 9 264
46 int:PRKN PRKN interactions 9.423E-8 4.031E-6 3.291E-5 1.854E-4 11 461
47 int:BIK BIK interactions 1.269E-7 5.312E-6 4.335E-5 2.496E-4 4 16
48 int:FADD FADD interactions 1.364E-7 5.594E-6 4.566E-5 2.685E-4 6 80
49 int:UQCRH UQCRH interactions 1.750E-7 7.030E-6 5.738E-5 3.445E-4 5 43
50 int:UQCRQ UQCRQ interactions 1.963E-7 7.576E-6 6.184E-5 3.864E-4 6 85
Show 45 more annotations

10: Cytoband [Display Chart] 50 input genes in category / 45 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2q33-q34 2q33-q34 7.294E-5 3.282E-3 1.443E-2 3.282E-3 2 9
2 19q13.3-q13.4 19q13.3-q13.4 1.575E-4 3.543E-3 1.557E-2 7.086E-3 2 13
3 22q11.1 22q11.1 1.315E-3 1.973E-2
8.670E-2
5.918E-2
 2 37
4 20q11.21 20q11.21 2.205E-3 2.481E-2
1.090E-1
9.922E-2
 2 48
5 5q11.2-q13.3 5q11.2-q13.3 2.883E-3 2.595E-2
1.140E-1
1.297E-1
 1 2
6 9q33-q34 9q33-q34 5.758E-3 4.318E-2
1.898E-1
2.591E-1
 1 4
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 38 input genes in category / 259 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 48 input genes in category / 32 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 642 Mitochondrial complex III: ubiquinol-cytochrome c reductase complex subunits genenames.org 6.716E-17 2.149E-15 8.722E-15 2.149E-15 7 10
2 1057 BCL2 family genenames.org 1.906E-15 3.049E-14 1.237E-13 6.098E-14 7 14
3 1277 BCL2 homology region 3 (BH3) only genenames.org 1.115E-13 1.190E-12 4.828E-12 3.569E-12 6 11
4 643 Mitochondrial complex IV: cytochrome c oxidase subunits genenames.org 1.166E-9 9.332E-9 3.787E-8 3.733E-8 5 19
5 1340 Ripoptosome genenames.org 1.723E-8 1.103E-7 4.476E-7 5.515E-7 3 3
6 1341 Mitochondrial complex III: ubiquinol-cytochrome c reductase complex subunits|Apoptosome genenames.org 2.041E-5 1.089E-4 4.418E-4 6.532E-4 2 3
7 959 Caspase recruitment domain containing genenames.org 6.655E-5 3.042E-4 1.235E-3 2.130E-3 3 30
8 1342 CD molecules|Tumor necrosis factor receptor superfamily|Death inducing signaling complex genenames.org 1.015E-4 4.062E-4 1.649E-3 3.250E-3 2 6
9 1019 Death effector domain containing|Ripoptosome|Death inducing signaling complex genenames.org 1.419E-4 5.046E-4 2.048E-3 4.542E-3 2 7
10 468 Caspases genenames.org 5.219E-4 1.670E-3 6.777E-3 1.670E-2 2 13
11 1149 NADH:ubiquinone oxidoreductase core subunits genenames.org 6.078E-4 1.768E-3 7.176E-3 1.945E-2 2 14
12 694 Protein phosphatase 1 regulatory subunits genenames.org 1.310E-3 3.494E-3 1.418E-2 4.193E-2 4 181
13 306 Voltage dependent anion channels genenames.org 7.894E-3 1.943E-2
7.886E-2
2.526E-1
 1 3
14 954 Phospholipid scramblases genenames.org 1.312E-2 2.800E-2
1.136E-1
4.199E-1
 1 5
15 1021 Ankyrin repeat domain containing|Death associated protein kinases genenames.org 1.312E-2 2.800E-2
1.136E-1
4.199E-1
 1 5
16 1309 BTG/Tob family genenames.org 1.573E-2 3.146E-2
1.277E-1
5.033E-1
 1 6
17 1056 Ring finger proteins|WD repeat domain containing|TNF receptor associated factors genenames.org 1.833E-2 3.449E-2
1.400E-1
5.864E-1
 1 7
18 419 Ring finger proteins|Baculoviral IAP repeat containing|Caspase recruitment domain containing genenames.org 2.092E-2 3.718E-2
1.509E-1
6.693E-1
 1 8
19 1174 Lysozymes, c-type genenames.org 2.350E-2 3.958E-2
1.606E-1
7.520E-1
 1 9
20 445 Oligosaccharyltransferase complex subunits genenames.org 3.121E-2 4.994E-2
2.027E-1
9.988E-1
 1 12
Show 15 more annotations

13: Coexpression [Display Chart] 52 input genes in category / 4772 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20179162-Table1 Human Lung Tahir10 14genes GeneSigDB 3.821E-31 1.824E-27 1.650E-26 1.824E-27 12 14
2 M9433 Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.528E-25 1.796E-21 1.625E-20 3.592E-21 22 429
3 M9577 Mitochondrial genes MSigDB C2: CGP Curated Gene Sets (v6.0) 1.859E-24 2.957E-21 2.675E-20 8.871E-21 22 447
4 M9642 Proteins that permeabilize mitochondria. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.149E-23 7.336E-20 6.638E-19 2.934E-19 12 43
5 M5936 Genes encoding proteins involved in oxidative phosphorylation. MSigDB H: Hallmark Gene Sets (v6.0) 2.236E-19 2.134E-16 1.931E-15 1.067E-15 15 200
6 M7952 Proteins acting on mitochondria to prevent membrane permeabilization. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.425E-19 2.724E-16 2.465E-15 1.634E-15 9 22
7 M18264 Genes involved in oxidative phosphorylation; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.627E-19 4.518E-16 4.088E-15 3.162E-15 12 87
8 M5902 Genes mediating programmed cell death (apoptosis) by activation of caspases. MSigDB H: Hallmark Gene Sets (v6.0) 2.754E-17 1.643E-14 1.486E-13 1.314E-13 13 161
9 20179162-Table3c Human Lung Tahir10 8genes C GeneSigDB 9.561E-17 5.070E-14 4.587E-13 4.563E-13 6 6
10 17804543-Table2 Human Leukemia Achiron07 55genes GeneSigDB 1.646E-15 7.855E-13 7.107E-12 7.855E-12 9 50
11 M8023 Genes whose transcription is up-regulated by histone deacetylase inhibitors. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.536E-14 1.968E-11 1.780E-10 2.165E-10 7 23
12 17682054-Table1 Human Bone Lu07 301genes GeneSigDB 7.682E-14 3.055E-11 2.764E-10 3.666E-10 13 296
13 M1411 Genes up-regulated by UV-irradiation in cervical cancer cells after knockdown of CDKN2A [GeneID=1029]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.160E-13 1.527E-10 1.382E-9 1.985E-9 8 55
14 17369842-Table1 Human Cervical Lau07 60genes GeneSigDB 7.524E-13 2.472E-10 2.237E-9 3.591E-9 8 59
15 M9440 NF-kB target genes involved in the regulation of programmed cell death. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.771E-13 2.472E-10 2.237E-9 3.708E-9 7 33
16 20179162-Table2c Human Lung Tahir10 6genes GeneSigDB 2.268E-11 6.764E-9 6.120E-8 1.082E-7 4 4
17 M15112 Genes that comprise the mitochondria gene module MSigDB C2: CGP Curated Gene Sets (v6.0) 4.800E-11 1.347E-8 1.219E-7 2.291E-7 10 217
18 16189266-Table2 Human Leukemia Holleman06 17genes GeneSigDB 5.975E-11 1.584E-8 1.433E-7 2.851E-7 5 13
19 17571080-SuppTable2b Human Leukemia Sun07 283genes GeneSigDB 1.345E-10 3.378E-8 3.056E-7 6.418E-7 10 241
20 15972852-Table1 Human Ovarian Horak05 31genes GeneSigDB 2.018E-10 4.814E-8 4.355E-7 9.628E-7 5 16
21 M15615 Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon gamma for 6 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.267E-10 5.152E-8 4.662E-7 1.082E-6 7 71
22 15896717-Table3 Human Leukemia Bal05 10genes GeneSigDB 2.834E-9 6.147E-7 5.562E-6 1.352E-5 4 9
23 19643001-Additional-File2 Rat Breast Giusti09 300genes GeneSigDB 4.512E-9 9.361E-7 8.470E-6 2.153E-5 8 172
24 M6752 Genes essential to the development of megakaryocytes, as expressed in normal cells and essential thrombocythemic cells (ET). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.842E-9 1.559E-6 1.411E-5 3.742E-5 6 66
25 18477771-Table1 Human Leukemia Shah08 34genes GeneSigDB 1.065E-8 2.033E-6 1.839E-5 5.083E-5 5 33
26 M8969 Genes down-regulated in CD4 [GeneID=920] over-expressing: FOXP3 [GeneID=50943] and PPARg2 form of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v6.0) 1.472E-8 2.702E-6 2.444E-5 7.024E-5 8 200
27 M3652 Genes up-regulated in HT1080 cells (fibrosarcoma) by treatment with interferon alpha for 6 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.577E-8 2.788E-6 2.522E-5 7.526E-5 6 74
28 19795415-Table1 Mouse Lung Beisiegel09 262genes GeneSigDB 1.925E-8 3.280E-6 2.968E-5 9.185E-5 8 207
29 20215539-SuppTable2a Human Lymphoma Dickens10 97genes GeneSigDB 6.283E-8 1.034E-5 9.354E-5 2.998E-4 6 93
30 19120899-Table2b Human Viral Mimori08 6genes GeneSigDB 1.067E-7 1.647E-5 1.490E-4 5.093E-4 3 5
31 15026349-Table3b Human Lung Carson04 31genes GeneSigDB 1.070E-7 1.647E-5 1.490E-4 5.106E-4 4 20
32 15897243-Table1 Human Lymphoma Zhu05 61genes GeneSigDB 1.370E-7 2.043E-5 1.848E-4 6.536E-4 5 54
33 M18491 Genes up-regulated by ESRRA [GeneID=2101] only. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.861E-7 2.691E-5 2.435E-4 8.881E-4 9 388
34 M7611 Genes up-regulated in memory CD8 T cells: 2' versus 3'. MSigDB C7: Immunologic Signatures (v6.0) 3.125E-7 4.142E-5 3.748E-4 1.491E-3 7 200
35 M3502 Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 80 min. MSigDB C7: Immunologic Signatures (v6.0) 3.125E-7 4.142E-5 3.748E-4 1.491E-3 7 200
36 M4525 Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th1 cells at 48 h. MSigDB C7: Immunologic Signatures (v6.0) 3.125E-7 4.142E-5 3.748E-4 1.491E-3 7 200
37 15674362-SuppTable3 Mouse Leukemia Mackus05 08genes GeneSigDB 3.724E-7 4.803E-5 4.345E-4 1.777E-3 3 7
38 15963930-Table1 Human StemCell Lam05 32genes GeneSigDB 5.167E-7 6.489E-5 5.871E-4 2.466E-3 4 29
39 20067540-Table3 Human UmbilicalCordBloodCells Miyagawa09 145genes GeneSigDB 7.137E-7 8.733E-5 7.901E-4 3.406E-3 6 140
40 15741219-Table3 Human StemCell Roth05 33genes GeneSigDB 8.844E-7 1.055E-4 9.546E-4 4.220E-3 4 33
41 19286929-SuppTable2d Mouse Lung Rangasamy09 36genes GeneSigDB 1.001E-6 1.165E-4 1.054E-3 4.775E-3 4 34
42 M73 Genes up-regulated in primary tissue culture of epidermal kerationcytes after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.429E-6 1.623E-4 1.469E-3 6.818E-3 5 86
43 15988031-TableS5 Human StemCell Li05 279genes GeneSigDB 1.616E-6 1.793E-4 1.622E-3 7.710E-3 6 161
44 M13713 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 13. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.372E-6 2.572E-4 2.327E-3 1.132E-2 6 172
45 M3456 Genes identified by ChIP within the high-affinity group of MYC [GeneID=4609] targets. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.289E-6 3.450E-4 3.122E-3 1.569E-2 6 182
46 M13453 Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon beta for 6 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.326E-6 3.450E-4 3.122E-3 1.587E-2 5 102
47 16270046-SuppTable1 Human Lymphoma Martinez-Delgado05 135genes GeneSigDB 3.836E-6 3.895E-4 3.524E-3 1.831E-2 5 105
48 M1678 Strongly up-regulated at 96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.088E-6 4.064E-4 3.677E-3 1.951E-2 6 189
49 M3362 Genes whose transcription is down-regulated by histone deacetylase inhibitors. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.780E-6 4.227E-4 3.825E-3 2.281E-2 3 15
50 M5205 Genes up-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to M. tuberculosis. MSigDB C7: Immunologic Signatures (v6.0) 5.499E-6 4.227E-4 3.825E-3 2.624E-2 6 199
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 53 input genes in category / 2800 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-D/Kidney Normal Wilms EN-D/Kidney Normal Wilms EN14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-D/Kidney Normal Wilms EN-D/Kidney Normal Wilms EN14 Adult, Development, and Cancer types 5.353E-8 1.489E-4 1.268E-3 1.499E-4 7 143
2 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells immature neurons immature neurons Subtype immature neurons s1 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells immature neurons immature neurons Subtype immature neurons s1 Top 200 Genes StanfordMouse+HumanSingleCells 3.024E-7 1.489E-4 1.268E-3 8.468E-4 8 274
3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney B cell/Kidney Normal-Medulla Wilms B cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney B cell/Kidney Normal-Medulla Wilms B cell Adult, Development, and Cancer types 3.109E-7 1.489E-4 1.268E-3 8.704E-4 7 185
4 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/cardiac muscle cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/cardiac muscle cell Tabula Muris Consortium 3.343E-7 1.489E-4 1.268E-3 9.362E-4 7 187
5 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Cortex Wilms Nephron epithelium/Kidney Normal-Cortex Wilms N17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Cortex Wilms Nephron epithelium/Kidney Normal-Cortex Wilms N17 Adult, Development, and Cancer types 3.724E-7 1.489E-4 1.268E-3 1.043E-3 7 190
6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Tumour VHL RCC Th cell/Kidney Tumour VHL RCC IT19 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Tumour VHL RCC Th cell/Kidney Tumour VHL RCC IT19 Adult, Development, and Cancer types 3.724E-7 1.489E-4 1.268E-3 1.043E-3 7 190
7 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells immature neurons immature neurons Overall Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells immature neurons immature neurons Overall Top 200 Genes StanfordMouse+HumanSingleCells 3.724E-7 1.489E-4 1.268E-3 1.043E-3 7 190
8 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells immature neurons immature neurons Subtype immature neurons s7 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells immature neurons immature neurons Subtype immature neurons s7 Top 200 Genes StanfordMouse+HumanSingleCells 5.712E-7 1.999E-4 1.702E-3 1.599E-3 8 298
9 Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte progenitor Enterocyte progenitor Subtype progenitor Jejunum Top 200 Genes Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte progenitor Enterocyte progenitor Subtype progenitor Jejunum Top 200 Genes Mouse Cell Atlas 6.476E-7 2.006E-4 1.708E-3 1.813E-3 8 303
10 Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte Enterocyte Subtype Enterocyte Jejunum Top 200 Genes Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte Enterocyte Subtype Enterocyte Jejunum Top 200 Genes Mouse Cell Atlas 7.690E-7 2.006E-4 1.708E-3 2.153E-3 8 310
11 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells immature neurons immature neurons Subtype immature neurons s6 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells immature neurons immature neurons Subtype immature neurons s6 Top 200 Genes StanfordMouse+HumanSingleCells 7.879E-7 2.006E-4 1.708E-3 2.206E-3 8 311
12 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells mature neurons mature neurons Subtype mature neurons s1 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells mature neurons mature neurons Subtype mature neurons s1 Top 200 Genes StanfordMouse+HumanSingleCells 9.390E-7 2.191E-4 1.866E-3 2.629E-3 7 218
13 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells immature neurons immature neurons Subtype immature neurons s3 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells immature neurons immature neurons Subtype immature neurons s3 Top 200 Genes StanfordMouse+HumanSingleCells 1.423E-6 3.065E-4 2.610E-3 3.985E-3 7 232
14 Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte Enterocyte Top 200 Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte Enterocyte Top 200 Mouse Cell Atlas 1.888E-6 3.776E-4 3.216E-3 5.287E-3 9 474
15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal RCC IF-U/Kidney Normal RCC IF16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal RCC IF-U/Kidney Normal RCC IF16 Adult, Development, and Cancer types 3.233E-6 6.036E-4 5.139E-3 9.054E-3 6 168
16 10X Human 68K PBMC CD8+ Cytotoxic T Subtype CD8+ Cytotoxic T-CD8+ Cytotoxic T c7 Top 200 Genes 10X Human 68K PBMC CD8+ Cytotoxic T Subtype CD8+ Cytotoxic T-CD8+ Cytotoxic T c7 Top 200 Genes 3.933E-6 6.176E-4 5.258E-3 1.101E-2 8 386
17 10X Human 68K PBMC CD8+ Cytotoxic T Subtype CD8+ Cytotoxic T-CD8+ Cytotoxic T c4 Top 200 Genes 10X Human 68K PBMC CD8+ Cytotoxic T Subtype CD8+ Cytotoxic T-CD8+ Cytotoxic T c4 Top 200 Genes 4.405E-6 6.176E-4 5.258E-3 1.233E-2 8 392
18 10X Human 8K PBMC Immune Subtype Immune-STMN1 TK1 KIAA0101 Top 200 Genes 10X Human 8K PBMC Immune Subtype Immune-STMN1 TK1 KIAA0101 Top 200 Genes 4.405E-6 6.176E-4 5.258E-3 1.233E-2 8 392
19 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Cortex post-natal kidney IF-U/Kidney Normal-Cortex post-natal kidney IF16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Cortex post-natal kidney IF-U/Kidney Normal-Cortex post-natal kidney IF16 Adult, Development, and Cancer types 4.969E-6 6.176E-4 5.258E-3 1.391E-2 6 181
20 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal RCC PT-U/Kidney Normal RCC PT16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal RCC PT-U/Kidney Normal RCC PT16 Adult, Development, and Cancer types 5.129E-6 6.176E-4 5.258E-3 1.436E-2 6 182
21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Wilms tumour/Kidney Normal-Medulla post-natal kidney Wilms tumour/Kidney Normal-Medulla post-natal kidney T16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Wilms tumour/Kidney Normal-Medulla post-natal kidney Wilms tumour/Kidney Normal-Medulla post-natal kidney T16 Adult, Development, and Cancer types 5.129E-6 6.176E-4 5.258E-3 1.436E-2 6 182
22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2-like/Kidney Normal Wilms MNP2-like Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2-like/Kidney Normal Wilms MNP2-like Adult, Development, and Cancer types 5.129E-6 6.176E-4 5.258E-3 1.436E-2 6 182
23 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Proliferating NK cell/Kidney Normal-Cortex post-natal kidney Proliferating NK cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Proliferating NK cell/Kidney Normal-Cortex post-natal kidney Proliferating NK cell Adult, Development, and Cancer types 5.129E-6 6.176E-4 5.258E-3 1.436E-2 6 182
24 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal-Cortex Wilms Normal cell/Kidney Normal-Cortex Wilms T14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal-Cortex Wilms Normal cell/Kidney Normal-Cortex Wilms T14 Adult, Development, and Cancer types 5.293E-6 6.176E-4 5.258E-3 1.482E-2 6 183
25 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney Tumour PapRCC EN-U/Kidney Tumour PapRCC EN15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney Tumour PapRCC EN-U/Kidney Tumour PapRCC EN15 Adult, Development, and Cancer types 5.634E-6 6.258E-4 5.329E-3 1.578E-2 6 185
26 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Wilms tumour/Kidney Normal-Cortex post-natal kidney Wilms tumour/Kidney Normal-Cortex post-natal kidney T16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Wilms tumour/Kidney Normal-Cortex post-natal kidney Wilms tumour/Kidney Normal-Cortex post-natal kidney T16 Adult, Development, and Cancer types 5.811E-6 6.258E-4 5.329E-3 1.627E-2 6 186
27 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal RCC NK cell/Kidney Normal RCC NK17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal RCC NK cell/Kidney Normal RCC NK17 Adult, Development, and Cancer types 7.397E-6 7.012E-4 5.971E-3 2.071E-2 6 194
28 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal-Cortex post-natal kidney Normal cell/Kidney Normal-Cortex post-natal kidney T14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal-Cortex post-natal kidney Normal cell/Kidney Normal-Cortex post-natal kidney T14 Adult, Development, and Cancer types 7.618E-6 7.012E-4 5.971E-3 2.133E-2 6 195
29 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells mature neurons mature neurons Overall Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells mature neurons mature neurons Overall Top 200 Genes StanfordMouse+HumanSingleCells 7.618E-6 7.012E-4 5.971E-3 2.133E-2 6 195
30 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells immature neurons immature neurons Subtype immature neurons s9 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells immature neurons immature neurons Subtype immature neurons s9 Top 200 Genes StanfordMouse+HumanSingleCells 7.746E-6 7.012E-4 5.971E-3 2.169E-2 7 300
31 10X Human 68K PBMC CD8+ Cytotoxic T Overall Top 200 Genes 10X Human 68K PBMC CD8+ Cytotoxic T Overall Top 200 Genes 7.844E-6 7.012E-4 5.971E-3 2.196E-2 6 196
32 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2-like/Kidney Normal-Medulla Wilms MNP2-like Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2-like/Kidney Normal-Medulla Wilms MNP2-like Adult, Development, and Cancer types 8.075E-6 7.012E-4 5.971E-3 2.261E-2 6 197
33 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells mature neurons mature neurons Subtype mature neurons s5 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells mature neurons mature neurons Subtype mature neurons s5 Top 200 Genes StanfordMouse+HumanSingleCells 8.264E-6 7.012E-4 5.971E-3 2.314E-2 7 303
34 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Neutrophil/Kidney Tumour Wilms Neutrophil/Kidney Tumour Wilms IN11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Neutrophil/Kidney Tumour Wilms Neutrophil/Kidney Tumour Wilms IN11 Adult, Development, and Cancer types 8.950E-6 7.371E-4 6.276E-3 2.506E-2 4 54
35 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Cortex Wilms IF-U/Kidney Normal-Cortex Wilms IF14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Cortex Wilms IF-U/Kidney Normal-Cortex Wilms IF14 Adult, Development, and Cancer types 9.485E-6 7.588E-4 6.461E-3 2.656E-2 5 117
36 JC iEC 2500 K3 JC iEC top-relative-expression-ranked 2500 k-means-cluster#3 PCBC 9.996E-6 7.775E-4 6.620E-3 2.799E-2 7 312
37 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells mature neurons mature neurons Subtype mature neurons s7 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells mature neurons mature neurons Subtype mature neurons s7 Top 200 Genes StanfordMouse+HumanSingleCells 1.409E-5 1.066E-3 9.081E-3 3.946E-2 7 329
38 Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte progenitor Enterocyte progenitor Subtype progenitor Duodenum Top 200 Genes Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte progenitor Enterocyte progenitor Subtype progenitor Duodenum Top 200 Genes Mouse Cell Atlas 1.553E-5 1.144E-3 9.745E-3 4.349E-2 7 334
39 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype Granulocytic-UNK Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype Granulocytic-UNK Top 200 Genes 1.614E-5 1.159E-3 9.868E-3 4.520E-2 7 336
40 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney NephrogenicRest Wilms Ureter epithelium/Kidney NephrogenicRest Wilms N10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney NephrogenicRest Wilms Ureter epithelium/Kidney NephrogenicRest Wilms N10 Adult, Development, and Cancer types 1.704E-5 1.192E-3 1.015E-2 4.770E-2 5 132
41 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells mature neurons mature neurons Subtype mature neurons s9 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells mature neurons mature neurons Subtype mature neurons s9 Top 200 Genes StanfordMouse+HumanSingleCells 2.604E-5 1.767E-3 1.504E-2
7.290E-2
 7 362
42 Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC7 Top 200 Genes Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC7 Top 200 Genes 2.650E-5 1.767E-3 1.504E-2
7.420E-2
 7 363
43 10X Human 8K PBMC CD8 T cell Subtype CD8 T cell-CD8B RP11-291B21.2 S100B Top 200 Genes 10X Human 8K PBMC CD8 T cell Subtype CD8 T cell-CD8B RP11-291B21.2 S100B Top 200 Genes 2.942E-5 1.891E-3 1.610E-2
8.238E-2
 7 369
44 Kidney10XCellRanger Six2TGC TSC1 P0 UB UB Subtype P0-Six2TGC Tsc1-UB-C5-KC9 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 UB UB Subtype P0-Six2TGC Tsc1-UB-C5-KC9 Top 200 Genes 2.972E-5 1.891E-3 1.610E-2
8.322E-2
 6 248
45 10X Human 8K PBMC T cell Subtype T cell-CD8B RP11-291B21.2 S100B Top 200 Genes 10X Human 8K PBMC T cell Subtype T cell-CD8B RP11-291B21.2 S100B Top 200 Genes 3.045E-5 1.894E-3 1.613E-2
8.527E-2
 7 371
46 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells neuroblast- precursors neuroblast- precursors Subtype neuroblast- precursors s4 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells neuroblast- precursors neuroblast- precursors Subtype neuroblast- precursors s4 Top 200 Genes StanfordMouse+HumanSingleCells 3.151E-5 1.894E-3 1.613E-2
8.824E-2
 7 373
47 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.3 Intermediate.3 Top 100 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.3 Intermediate.3 Top 100 3.179E-5 1.894E-3 1.613E-2
8.902E-2
 6 251
48 10X Human 68K PBMC CD8+ Cytotoxic T Subtype CD8+ Cytotoxic T-CD8+ Cytotoxic T c3 Top 200 Genes 10X Human 68K PBMC CD8+ Cytotoxic T Subtype CD8+ Cytotoxic T-CD8+ Cytotoxic T c3 Top 200 Genes 3.373E-5 1.967E-3 1.675E-2
9.443E-2
 7 377
49 10X Human 68K PBMC CD8+ Cytotoxic T Subtype CD8+ Cytotoxic T-CD8+ Cytotoxic T c8 Top 200 Genes 10X Human 68K PBMC CD8+ Cytotoxic T Subtype CD8+ Cytotoxic T-CD8+ Cytotoxic T c8 Top 200 Genes 3.488E-5 1.993E-3 1.697E-2
9.766E-2
 7 379
50 10X Human 68K PBMC CD19+ B Subtype CD19+ B-CD19+ B c6 Top 200 Genes 10X Human 68K PBMC CD19+ B Subtype CD19+ B-CD19+ B c6 Top 200 Genes 4.048E-5 2.267E-3 1.930E-2
1.133E-1
 7 388
Show 45 more annotations

15: Computational [Display Chart] 41 input genes in category / 255 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M19044 MODULE 152 Oxidative phosphorylation and ATP synthesis. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.508E-12 2.043E-10 1.250E-9 3.845E-10 11 124
2 M16474 MODULE 62 Genes in the cancer module 62. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.602E-12 2.043E-10 1.250E-9 4.086E-10 10 89
3 M13513 MODULE 307 Oxidative phosphorylation (COX and ATPases). MSigDb: C4 - CM: Cancer Modules (v6.0) 5.305E-10 4.510E-8 2.760E-7 1.353E-7 6 25
4 M18002 MORF CSNK2B Neighborhood of CSNK2B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.950E-10 5.705E-8 3.492E-7 2.282E-7 12 287
5 M3301 MODULE 399 Genes in the cancer module 399. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.995E-6 1.018E-4 6.228E-4 5.088E-4 5 52
6 M10738 MODULE 77 Genes in the cancer module 77. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.571E-6 1.943E-4 1.189E-3 1.166E-3 4 28
7 M10134 MODULE 93 Oxidoreductases. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.669E-6 2.550E-4 1.561E-3 1.956E-3 7 182
8 M4246 MORF EIF3S6 Neighborhood of EIF3S6 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.633E-6 2.550E-4 1.561E-3 2.201E-3 6 121
9 M4219 MODULE 300 Programmed cell death. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.001E-6 2.550E-4 1.561E-3 2.295E-3 4 33
10 M17615 MORF RAN Neighborhood of RAN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.035E-5 2.639E-4 1.615E-3 2.639E-3 8 268
11 M7895 MORF SOD1 Neighborhood of SOD1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.317E-5 3.051E-4 1.867E-3 3.358E-3 8 277
12 M11552 MODULE 149 Translation factors. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.436E-5 3.051E-4 1.867E-3 3.661E-3 4 37
13 M11080 MORF HDAC1 Neighborhood of HDAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.591E-5 1.293E-3 7.913E-3 1.681E-2 7 254
14 M16184 MORF ERH Neighborhood of ERH MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.360E-5 1.705E-3 1.043E-2 2.387E-2 5 114
15 M10736 MODULE 151 Genes in the cancer module 151. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.667E-4 4.417E-3 2.703E-2
6.801E-2
 7 318
16 M4842 MODULE 83 Genes in the cancer module 83. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.771E-4 4.417E-3 2.703E-2
7.067E-2
 7 320
17 M16804 MODULE 114 Protein biosynthesis and ribosomes. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.865E-4 5.797E-3 3.548E-2
9.855E-2
 7 338
18 M18698 MORF EIF3S2 Neighborhood of EIF3S2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.275E-4 6.057E-3 3.707E-2
1.090E-1
 6 244
19 M12947 MORF CTBP1 Neighborhood of CTBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.697E-4 7.646E-3 4.680E-2
1.453E-1
 5 168
20 M19767 MORF G22P1 Neighborhood of G22P1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.175E-4 7.873E-3 4.819E-2
1.575E-1
 5 171
21 M5974 MODULE 43 Energy pathways. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.817E-4 8.278E-3
5.066E-2
1.738E-1
 4 99
22 M13419 MORF BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.193E-4 9.496E-3
5.812E-2
2.089E-1
 6 276
23 M3611 MODULE 103 Genes in the cancer module 103. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.047E-3 1.133E-2
6.933E-2
2.670E-1
 2 12
24 M6058 MORF DAP3 Neighborhood of DAP3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.066E-3 1.133E-2
6.933E-2
2.719E-1
 5 193
25 M19884 MORF ANP32B Neighborhood of ANP32B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.169E-3 1.166E-2
7.134E-2
2.980E-1
 5 197
26 M413 MODULE 273 Phosphate metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.217E-3 1.166E-2
7.134E-2
3.103E-1
 3 52
27 M6259 MODULE 25 Genes in the cancer module 25. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.234E-3 1.166E-2
7.134E-2
3.147E-1
 2 13
28 M18524 MORF GMPS Neighborhood of GMPS MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.286E-3 1.171E-2
7.170E-2
3.280E-1
 3 53
29 M2967 MORF AP2M1 Neighborhood of AP2M1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.793E-3 1.566E-2
9.583E-2
4.573E-1
 5 217
30 M667 MODULE 254 Genes in the cancer module 254. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.842E-3 1.566E-2
9.583E-2
4.697E-1
 3 60
31 M7309 MORF RAD23A Neighborhood of RAD23A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.567E-3 2.065E-2
1.264E-1
6.546E-1
 6 345
32 M18071 MORF PRKAR1A Neighborhood of PRKAR1A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.591E-3 2.065E-2
1.264E-1
6.607E-1
 4 142
33 M10939 MORF UBE2I Neighborhood of UBE2I MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.684E-3 2.074E-2
1.269E-1
6.845E-1
 5 238
34 M7191 MORF DEK Neighborhood of DEK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.055E-3 3.041E-2
1.861E-1
1.000E0
 5 262
35 M15800 MODULE 42 Genes in the cancer module 42. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.602E-3 3.333E-2
2.040E-1
1.000E0
 2 25
36 M3784 MORF PRDX3 Neighborhood of PRDX3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.793E-3 3.333E-2
2.040E-1
1.000E0
 3 84
37 M7181 MORF PPP1CA Neighborhood of PPP1CA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.835E-3 3.333E-2
2.040E-1
1.000E0
 4 169
38 M10404 MORF MBD4 Neighborhood of MBD4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.119E-3 3.435E-2
2.103E-1
1.000E0
 3 86
39 M11132 MORF RAD21 Neighborhood of RAD21 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.277E-3 4.104E-2
2.512E-1
1.000E0
 4 182
40 M19325 MORF PSMC1 Neighborhood of PSMC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.293E-3 4.641E-2
2.840E-1
1.000E0
 4 190
41 M18398 MORF GNB1 Neighborhood of GNB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.461E-3 4.641E-2
2.840E-1
1.000E0
 5 303
Show 36 more annotations

16: MicroRNA [Display Chart] 53 input genes in category / 1785 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-125b-5p:Functional MTI Functional MTI miRTarbase 1.827E-14 3.261E-11 2.630E-10 3.261E-11 11 431
2 hsa-miR-29a-3p:Functional MTI Functional MTI miRTarbase 1.102E-9 9.834E-7 7.930E-6 1.967E-6 7 265
3 hsa-miR-214-3p:Functional MTI Functional MTI miRTarbase 1.026E-8 5.380E-6 4.339E-5 1.831E-5 6 206
4 hsa-miR-181b-5p:Functional MTI Functional MTI miRTarbase 1.206E-8 5.380E-6 4.339E-5 2.152E-5 7 375
5 hsa-miR-1284:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.336E-8 1.905E-5 1.536E-4 9.524E-5 4 49
6 hsa-miR-429:Functional MTI Functional MTI miRTarbase 9.879E-8 2.939E-5 2.370E-4 1.763E-4 5 151
7 hsa-miR-143-3p:TargetScan hsa-miR-143-3p TargetScan 2.158E-7 4.795E-5 3.867E-4 3.853E-4 6 345
8 hsa-miR-5000-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.283E-7 4.795E-5 3.867E-4 4.075E-4 4 70
9 hsa-miR-26a-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.418E-7 4.795E-5 3.867E-4 4.316E-4 4 71
10 hsa-miR-200b-3p:Functional MTI Functional MTI miRTarbase 2.783E-7 4.967E-5 4.006E-4 4.967E-4 5 186
11 hsa-miR-221-3p:Functional MTI Functional MTI miRTarbase 3.147E-7 5.107E-5 4.118E-4 5.617E-4 6 368
12 hsa-miR-378a-5p:Functional MTI Functional MTI miRTarbase 4.157E-7 6.184E-5 4.987E-4 7.421E-4 6 386
13 hsa-miR-200c-3p:Functional MTI Functional MTI miRTarbase 5.564E-7 7.639E-5 6.161E-4 9.931E-4 5 214
14 hsa-miR-143-3p:Functional MTI Functional MTI miRTarbase 7.601E-7 9.691E-5 7.815E-4 1.357E-3 5 228
15 hsa-miR-320c:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.307E-6 1.555E-4 1.254E-3 2.333E-3 4 108
16 hsa-miR-125a-5p:Functional MTI Functional MTI miRTarbase 1.741E-6 1.943E-4 1.567E-3 3.108E-3 5 270
17 hsa-miR-4763-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.191E-6 2.301E-4 1.855E-3 3.911E-3 5 283
18 hsa-miR-1207-5p:Functional MTI Functional MTI miRTarbase 2.386E-6 2.367E-4 1.909E-3 4.260E-3 5 288
19 hsa-miR-3120-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.574E-6 2.369E-4 1.911E-3 4.594E-3 4 128
20 hsa-miR-4762-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.655E-6 2.369E-4 1.911E-3 4.739E-3 4 129
21 hsa-miR-494-3p:Functional MTI Functional MTI miRTarbase 3.471E-6 2.950E-4 2.379E-3 6.195E-3 4 138
22 hsa-miR-361-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.109E-6 3.334E-4 2.689E-3 7.335E-3 4 144
23 hsa-miR-761:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.090E-6 3.951E-4 3.186E-3 9.086E-3 4 152
24 hsa-miR-149-5p:TargetScan hsa-miR-149-5p TargetScan 7.143E-6 5.312E-4 4.284E-3 1.275E-2 5 361
25 hsa-miR-301b-3p:Non-Functional MTI Non-Functional MTI miRTarbase 8.582E-6 6.127E-4 4.941E-3 1.532E-2 5 375
26 hsa-miR-3664-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.081E-6 6.139E-4 4.951E-3 1.621E-2 4 176
27 hsa-miR-4716-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.286E-6 6.139E-4 4.951E-3 1.658E-2 4 177
28 hsa-miR-301a-3p:Functional MTI Functional MTI miRTarbase 1.102E-5 7.025E-4 5.666E-3 1.967E-2 5 395
29 hsa-miR-744-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.769E-5 1.075E-3 8.669E-3 3.158E-2 5 436
30 hsa-miR-2861:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.807E-5 1.075E-3 8.669E-3 3.225E-2 3 68
31 hsa-miR-148a-3p:Functional MTI Functional MTI miRTarbase 1.921E-5 1.106E-3 8.920E-3 3.429E-2 4 213
32 hsa-miR-26a-5p:Functional MTI Functional MTI miRTarbase 2.215E-5 1.169E-3 9.426E-3 3.954E-2 5 457
33 hsa-miR-302b-3p:Functional MTI Functional MTI miRTarbase 2.285E-5 1.169E-3 9.426E-3 4.079E-2 5 460
34 hsa-miR-302d-3p:Functional MTI Functional MTI miRTarbase 2.285E-5 1.169E-3 9.426E-3 4.079E-2 5 460
35 hsa-miR-372-3p:Non-Functional MTI Non-Functional MTI miRTarbase 2.309E-5 1.169E-3 9.426E-3 4.122E-2 5 461
36 hsa-miR-10a-5p:Functional MTI Functional MTI miRTarbase 2.357E-5 1.169E-3 9.426E-3 4.208E-2 5 463
37 hsa-miR-630:Functional MTI Functional MTI miRTarbase 2.524E-5 1.217E-3 9.819E-3 4.505E-2 3 76
38 hsa-miR-375:Functional MTI Functional MTI miRTarbase 2.716E-5 1.265E-3 1.020E-2 4.849E-2 5 477
39 hsa-miR-1245b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.834E-5 1.265E-3 1.020E-2
5.059E-2
 3 79
40 hsa-miR-15a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.834E-5 1.265E-3 1.020E-2
5.059E-2
 3 79
41 hsa-miR-7160-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.998E-5 1.305E-3 1.053E-2
5.352E-2
 5 487
42 hsa-miR-4419b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.302E-5 1.322E-3 1.066E-2
5.894E-2
 5 497
43 hsa-miR-3929:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.334E-5 1.322E-3 1.066E-2
5.950E-2
 5 498
44 hsa-miR-4478:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.334E-5 1.322E-3 1.066E-2
5.950E-2
 5 498
45 hsa-miR-4435:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.370E-5 1.322E-3 1.066E-2
6.016E-2
 4 246
46 hsa-miR-133b:Functional MTI Functional MTI miRTarbase 3.406E-5 1.322E-3 1.066E-2
6.080E-2
 3 84
47 hsa-miR-29c-3p:Functional MTI Functional MTI miRTarbase 3.817E-5 1.450E-3 1.169E-2
6.813E-2
 4 254
48 hsa-miR-1272:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.915E-5 1.456E-3 1.174E-2
6.988E-2
 3 88
49 hsa-miR-29b-3p:Functional MTI Functional MTI miRTarbase 4.242E-5 1.545E-3 1.246E-2
7.572E-2
 4 261
50 hsa-miR-5583-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.471E-5 1.596E-3 1.287E-2
7.980E-2
 3 92
Show 45 more annotations

17: Drug [Display Chart] 53 input genes in category / 13400 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000006331 borane Stitch 1.295E-34 1.735E-30 1.749E-29 1.735E-30 25 269
2 CID000159822 AC1L4MJU Stitch 5.552E-32 3.720E-28 3.750E-27 7.440E-28 24 288
3 CID005287782 CID5287782 Stitch 2.743E-31 1.225E-27 1.235E-26 3.676E-27 19 112
4 CID000139760 borane (2 Stitch 2.510E-30 8.407E-27 8.475E-26 3.363E-26 17 75
5 CID000003549 HA14-1 Stitch 1.666E-29 4.465E-26 4.501E-25 2.232E-25 15 46
6 ctd:D007530 Isoflurane CTD 1.554E-25 3.472E-22 3.500E-21 2.083E-21 16 105
7 ctd:C522973 PI103 CTD 1.922E-25 3.678E-22 3.708E-21 2.575E-21 13 41
8 ctd:C554291 10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one CTD 1.824E-24 3.055E-21 3.079E-20 2.444E-20 10 14
9 CID000005102 NSC115907 Stitch 7.898E-24 1.176E-20 1.185E-19 1.058E-19 19 266
10 CID003036276 Ptpc Stitch 1.547E-23 2.073E-20 2.090E-19 2.073E-19 13 55
11 CID005326972 DB04680 Stitch 1.825E-23 2.223E-20 2.241E-19 2.445E-19 18 225
12 CID005497170 AC1NUZLU Stitch 4.055E-23 4.528E-20 4.564E-19 5.434E-19 18 235
13 ctd:C471405 sorafenib CTD 5.681E-23 5.856E-20 5.903E-19 7.612E-19 16 149
14 ctd:C002469 fusarenon-X CTD 9.260E-23 8.863E-20 8.934E-19 1.241E-18 12 43
15 CID003522484 AC1MRR4B Stitch 1.177E-22 1.051E-19 1.060E-18 1.577E-18 17 199
16 ctd:C540917 anthraceno(1,2-c)(1,2,5)selenadiazolo-6,11-dione CTD 2.083E-22 1.745E-19 1.759E-18 2.792E-18 9 12
17 ctd:C077990 alvocidib CTD 6.034E-22 4.756E-19 4.795E-18 8.086E-18 13 71
18 ctd:C559745 hyperforin dicyclohexylammonium CTD 6.759E-22 5.031E-19 5.072E-18 9.057E-18 9 13
19 CID000439171 Cytochrome c Stitch 2.264E-21 1.597E-18 1.609E-17 3.034E-17 13 78
20 CID000002505 C2-ceramide Stitch 2.717E-21 1.821E-18 1.835E-17 3.641E-17 18 296
21 ctd:C501332 ABT-737 CTD 3.512E-21 2.241E-18 2.259E-17 4.707E-17 10 24
22 CID000068636 AC1L2A54 Stitch 3.725E-21 2.269E-18 2.287E-17 4.991E-17 16 192
23 CID000004261 MS-275 Stitch 4.049E-21 2.359E-18 2.378E-17 5.426E-17 15 149
24 ctd:C022999 echinocystic acid CTD 4.339E-21 2.423E-18 2.442E-17 5.814E-17 8 9
25 ctd:C456800 ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate CTD 4.715E-21 2.527E-18 2.547E-17 6.318E-17 9 15
26 ctd:C004315 danthron CTD 5.844E-21 3.012E-18 3.036E-17 7.831E-17 10 25
27 ctd:C477361 LAQ824 CTD 7.605E-21 3.774E-18 3.805E-17 1.019E-16 11 40
28 CID000005311 vorinostat Stitch 7.898E-21 3.780E-18 3.810E-17 1.058E-16 18 314
29 ctd:C521792 DMU-212 CTD 1.655E-20 7.645E-18 7.707E-17 2.217E-16 13 90
30 CID000446965 AC1L9KAW Stitch 1.786E-20 7.977E-18 8.041E-17 2.393E-16 15 164
31 ctd:C523166 quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside CTD 2.282E-20 9.864E-18 9.944E-17 3.058E-16 9 17
32 ctd:D005665 Furosemide CTD 2.362E-20 9.889E-18 9.969E-17 3.165E-16 15 167
33 CID000001744 AC1L1C56 Stitch 2.593E-20 1.053E-17 1.062E-16 3.475E-16 17 272
34 CID000447920 ubiquinols Stitch 3.485E-20 1.373E-17 1.384E-16 4.670E-16 13 95
35 CID000002538 NSC302991 Stitch 6.487E-20 2.484E-17 2.504E-16 8.693E-16 18 353
36 ctd:C024352 fludarabine CTD 7.378E-20 2.746E-17 2.768E-16 9.886E-16 12 71
37 ctd:C016371 lonidamine CTD 8.642E-20 3.130E-17 3.155E-16 1.158E-15 9 19
38 ctd:C010329 azadirachtin CTD 1.569E-19 5.358E-17 5.401E-16 2.102E-15 9 20
39 ctd:C042198 nimbolide CTD 1.569E-19 5.358E-17 5.401E-16 2.102E-15 9 20
40 ctd:D064730 Dexrazoxane CTD 1.599E-19 5.358E-17 5.401E-16 2.143E-15 14 144
41 ctd:C078956 4-methylthioamphetamine CTD 2.397E-19 7.836E-17 7.898E-16 3.213E-15 7 7
42 CID000001062 AC1L1AN5 Stitch 5.058E-19 1.614E-16 1.627E-15 6.778E-15 15 204
43 ctd:C463759 codonoposide CTD 1.915E-18 5.831E-16 5.878E-15 2.566E-14 7 8
44 ctd:D014361 Trypsin Inhibitors CTD 1.915E-18 5.831E-16 5.878E-15 2.566E-14 7 8
45 ctd:C455139 myrtucommulone A CTD 3.324E-18 9.897E-16 9.976E-15 4.454E-14 10 43
46 CID000104806 peroxynitrite Stitch 5.496E-18 1.601E-15 1.614E-14 7.365E-14 17 373
47 CID000093860 Velcade (bortezomib Stitch 5.749E-18 1.639E-15 1.652E-14 7.704E-14 17 374
48 CID000122316 AGN 1135 Stitch 7.322E-18 2.022E-15 2.038E-14 9.812E-14 13 141
49 CID000002423 AC1L1DN5 Stitch 7.394E-18 2.022E-15 2.038E-14 9.908E-14 12 102
50 CID000002254 AC1L1D9R Stitch 8.355E-18 2.239E-15 2.257E-14 1.120E-13 12 103
Show 45 more annotations

18: Disease [Display Chart] 51 input genes in category / 1541 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0023452 Leukemia, Lymphocytic, Acute, L1 DisGeNET BeFree 3.855E-10 5.941E-7 4.704E-6 5.941E-7 13 420
2 C0555198 Malignant Glioma DisGeNET BeFree 6.853E-9 5.280E-6 4.181E-5 1.056E-5 12 432
3 C0206180 Ki-1+ Anaplastic Large Cell Lymphoma DisGeNET Curated 2.191E-8 1.091E-5 8.638E-5 3.377E-5 9 217
4 C1328840 Autoimmune Lymphoproliferative Syndrome DisGeNET Curated 2.832E-8 1.091E-5 8.638E-5 4.364E-5 5 29
5 C0221055 Paramyotonia Congenita (disorder) DisGeNET Curated 8.509E-8 2.623E-5 2.076E-4 1.311E-4 4 14
6 C0278883 Metastatic melanoma DisGeNET BeFree 1.712E-7 4.328E-5 3.427E-4 2.639E-4 10 366
7 C0858252 breast adenocarcinoma DisGeNET BeFree 2.137E-7 4.328E-5 3.427E-4 3.293E-4 7 136
8 C0007786 Brain Ischemia DisGeNET Curated 2.247E-7 4.328E-5 3.427E-4 3.462E-4 7 137
9 C0027055 Myocardial Reperfusion Injury DisGeNET Curated 2.596E-7 4.446E-5 3.520E-4 4.001E-4 6 85
10 C0006413 Burkitt Lymphoma DisGeNET Curated 3.079E-7 4.745E-5 3.757E-4 4.745E-4 10 390
11 C0333516 Tumor necrosis DisGeNET BeFree 6.460E-7 9.049E-5 7.165E-4 9.954E-4 8 235
12 C0334634 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse DisGeNET Curated 1.067E-6 1.371E-4 1.085E-3 1.645E-3 9 343
13 C0024314 Lymphoproliferative Disorders DisGeNET Curated 2.967E-6 3.517E-4 2.785E-3 4.572E-3 7 201
14 C0162670 Mitochondrial Myopathies DisGeNET Curated 3.942E-6 4.339E-4 3.435E-3 6.074E-3 5 76
15 C0153382 Malignant neoplasm of oropharynx DisGeNET BeFree 4.758E-6 4.888E-4 3.870E-3 7.332E-3 4 36
16 C0001125 Acidosis, Lactic DisGeNET Curated 5.302E-6 5.030E-4 3.982E-3 8.170E-3 6 142
17 C0242596 Neoplasm, Residual DisGeNET Curated 5.548E-6 5.030E-4 3.982E-3 8.550E-3 7 221
18 C0278996 Cancer of Head and Neck DisGeNET Curated 6.297E-6 5.063E-4 4.009E-3 9.704E-3 9 426
19 C0007787 Transient Ischemic Attack DisGeNET Curated 6.598E-6 5.063E-4 4.009E-3 1.017E-2 4 39
20 C2937358 Cerebral Hemorrhage DisGeNET Curated 7.314E-6 5.063E-4 4.009E-3 1.127E-2 4 40
21 C0153381 Malignant neoplasm of mouth DisGeNET BeFree 7.735E-6 5.063E-4 4.009E-3 1.192E-2 9 437
22 C0917798 Cerebral Ischemia DisGeNET Curated 7.846E-6 5.063E-4 4.009E-3 1.209E-2 7 233
23 C0220641 Lip and Oral Cavity Carcinoma DisGeNET BeFree 8.172E-6 5.063E-4 4.009E-3 1.259E-2 9 440
24 C0155017 Color Blindness, Blue DisGeNET Curated 8.214E-6 5.063E-4 4.009E-3 1.266E-2 3 13
25 C0278620 refractory plasma cell neoplasm DisGeNET BeFree 8.214E-6 5.063E-4 4.009E-3 1.266E-2 3 13
26 C0677483 carcinoma of the testis DisGeNET BeFree 1.043E-5 6.143E-4 4.864E-3 1.608E-2 3 14
27 C0268237 Cytochrome-c Oxidase Deficiency DisGeNET Curated 1.076E-5 6.143E-4 4.864E-3 1.659E-2 4 44
28 C0024301 Lymphoma, Follicular DisGeNET Curated 1.213E-5 6.673E-4 5.284E-3 1.869E-2 8 349
29 C0278601 Inflammatory Breast Carcinoma DisGeNET Curated 1.308E-5 6.952E-4 5.504E-3 2.016E-2 5 97
30 C0032285 Pneumonia DisGeNET Curated 1.533E-5 7.694E-4 6.092E-3 2.362E-2 9 476
31 C0376545 Hematologic Neoplasms DisGeNET Curated 1.585E-5 7.694E-4 6.092E-3 2.442E-2 9 478
32 cv:C0162671 Juvenile myopathy, encephalopathy, lactic acidosis AND stroke Clinical Variations 1.598E-5 7.694E-4 6.092E-3 2.462E-2 3 16
33 C0812413 Malignant Pleural Mesothelioma DisGeNET BeFree 1.681E-5 7.850E-4 6.216E-3 2.591E-2 7 262
34 OMIN:540000 MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKE-LIKE EPISODES; MELAS OMIM 1.936E-5 8.621E-4 6.826E-3 2.983E-2 3 17
35 C1961102 Precursor Cell Lymphoblastic Leukemia Lymphoma DisGeNET Curated 1.992E-5 8.621E-4 6.826E-3 3.069E-2 9 492
36 C0347959 Lactic acidemia DisGeNET Curated 2.014E-5 8.621E-4 6.826E-3 3.104E-2 5 106
37 C2004493 Leukemia, B-Cell DisGeNET BeFree 2.205E-5 9.183E-4 7.271E-3 3.398E-2 5 108
38 C0153452 Malignant neoplasm of gallbladder DisGeNET BeFree 2.474E-5 9.844E-4 7.795E-3 3.812E-2 6 186
39 C2349952 Oropharyngeal Carcinoma DisGeNET BeFree 2.636E-5 9.844E-4 7.795E-3 4.062E-2 4 55
40 C1857202 Frequent vomiting DisGeNET Curated 2.746E-5 9.844E-4 7.795E-3 4.232E-2 3 19
41 C1838993 Episodic vomiting DisGeNET Curated 2.746E-5 9.844E-4 7.795E-3 4.232E-2 3 19
42 C1857287 Stroke-like episodes DisGeNET Curated 2.746E-5 9.844E-4 7.795E-3 4.232E-2 3 19
43 C1961099 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma DisGeNET Curated 2.747E-5 9.844E-4 7.795E-3 4.233E-2 8 391
44 C1836122 SARCOIDOSIS, EARLY-ONSET DisGeNET Curated 2.907E-5 9.956E-4 7.883E-3 4.480E-2 2 3
45 C0302329 Malignant lymphoma centroblastic, diffuse DisGeNET BeFree 2.907E-5 9.956E-4 7.883E-3 4.480E-2 2 3
46 C1332078 Anaplastic large cell lymphoma, ALK negative DisGeNET BeFree 3.224E-5 1.080E-3 8.551E-3 4.968E-2 3 20
47 C0032463 Polycythemia Vera DisGeNET Curated 3.417E-5 1.120E-3 8.870E-3
5.265E-2
 6 197
48 C0016057 Fibrosarcoma DisGeNET Curated 3.755E-5 1.206E-3 9.546E-3
5.787E-2
 7 297
49 C0008149 Chlamydia Infections DisGeNET Curated 3.978E-5 1.251E-3 9.905E-3
6.130E-2
 4 61
50 C0374997 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site DisGeNET BeFree 5.133E-5 1.582E-3 1.253E-2
7.910E-2
 7 312
Show 45 more annotations