|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
23468174
|
Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.
|
Pubmed
|
4.254E-29
|
1.538E-26
|
1.101E-25
|
3.076E-26
|
7
|
7
|
2
|
23456092
|
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
|
Pubmed
|
4.254E-29
|
1.538E-26
|
1.101E-25
|
3.076E-26
|
7
|
7
|
3
|
9982
|
Human liver alcohol dehydrogenase: purification, composition, and catalytic features.
|
Pubmed
|
1.624E-24
|
2.936E-22
|
2.103E-21
|
1.174E-21
|
6
|
6
|
4
|
17185388
|
Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.
|
Pubmed
|
1.624E-24
|
2.936E-22
|
2.103E-21
|
1.174E-21
|
6
|
6
|
5
|
16685648
|
Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.
|
Pubmed
|
1.137E-23
|
1.644E-21
|
1.177E-20
|
8.221E-21
|
6
|
7
|
6
|
18331377
|
Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.
|
Pubmed
|
4.548E-23
|
5.481E-21
|
3.925E-20
|
3.288E-20
|
6
|
8
|
7
|
19193628
|
ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.
|
Pubmed
|
3.102E-20
|
3.204E-18
|
2.294E-17
|
2.243E-17
|
5
|
5
|
8
|
19874574
|
Genetical genomic determinants of alcohol consumption in rats and humans.
|
Pubmed
|
4.494E-18
|
4.061E-16
|
2.908E-15
|
3.249E-15
|
7
|
130
|
9
|
11784316
|
Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes.
|
Pubmed
|
3.948E-16
|
2.595E-14
|
1.858E-13
|
2.855E-13
|
4
|
4
|
10
|
19687126
|
A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.
|
Pubmed
|
3.948E-16
|
2.595E-14
|
1.858E-13
|
2.855E-13
|
4
|
4
|
11
|
12027900
|
Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3.
|
Pubmed
|
3.948E-16
|
2.595E-14
|
1.858E-13
|
2.855E-13
|
4
|
4
|
12
|
18996923
|
Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.
|
Pubmed
|
1.974E-15
|
1.098E-13
|
7.862E-13
|
1.427E-12
|
4
|
5
|
13
|
19861527
|
Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population.
|
Pubmed
|
1.974E-15
|
1.098E-13
|
7.862E-13
|
1.427E-12
|
4
|
5
|
14
|
19343046
|
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
|
Pubmed
|
1.074E-13
|
5.544E-12
|
3.970E-11
|
7.761E-11
|
6
|
193
|
15
|
19898482
|
Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
|
Pubmed
|
2.765E-13
|
1.333E-11
|
9.543E-11
|
1.999E-10
|
5
|
66
|
16
|
8621625
|
Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
17
|
24722735
|
Replication study of ESCC susceptibility genetic polymorphisms locating in the ADH1B-ADH1C-ADH7 cluster identified by GWAS.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
18
|
10424757
|
Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
19
|
2347582
|
The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
20
|
3006456
|
Genetics of human alcohol and aldehyde dehydrogenases.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
21
|
22079585
|
Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
22
|
2737681
|
Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
23
|
14745297
|
Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
24
|
16121213
|
Merging protein, gene and genomic data: the evolution of the MDR-ADH family.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
25
|
11836246
|
Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
26
|
2935875
|
Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
27
|
8892527
|
Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
28
|
7738026
|
Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
29
|
10358022
|
Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid.
|
Pubmed
|
3.770E-12
|
9.398E-11
|
6.730E-10
|
2.725E-9
|
3
|
3
|
30
|
17270348
|
Ontogeny of rdh9 (Crad3) expression: ablation causes changes in retinoid and steroid metabolizing enzymes, but RXR and androgen signaling seem normal.
|
Pubmed
|
1.080E-11
|
2.603E-10
|
1.864E-9
|
7.810E-9
|
4
|
30
|
31
|
16047160
|
Tissue- and species-specific expression patterns of class I, III, and IV Adh and Aldh 1 mRNAs in rodent embryos.
|
Pubmed
|
1.508E-11
|
3.303E-10
|
2.366E-9
|
1.090E-8
|
3
|
4
|
32
|
518534
|
Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3.
|
Pubmed
|
1.508E-11
|
3.303E-10
|
2.366E-9
|
1.090E-8
|
3
|
4
|
33
|
17257171
|
High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease.
|
Pubmed
|
1.508E-11
|
3.303E-10
|
2.366E-9
|
1.090E-8
|
3
|
4
|
34
|
20700531
|
The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.
|
Pubmed
|
3.769E-11
|
8.015E-10
|
5.740E-9
|
2.725E-8
|
3
|
5
|
35
|
19618839
|
Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells.
|
Pubmed
|
7.538E-11
|
1.514E-9
|
1.084E-8
|
5.450E-8
|
3
|
6
|
36
|
2169444
|
Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box.
|
Pubmed
|
7.538E-11
|
1.514E-9
|
1.084E-8
|
5.450E-8
|
3
|
6
|
37
|
11747070
|
Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally.
|
Pubmed
|
1.319E-10
|
2.577E-9
|
1.846E-8
|
9.536E-8
|
3
|
7
|
38
|
21437268
|
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
|
Pubmed
|
2.110E-10
|
4.015E-9
|
2.875E-8
|
1.526E-7
|
3
|
8
|
39
|
12128098
|
Expression of genes for alcohol and aldehyde metabolizing enzymes in mouse oocytes and preimplantation embryos.
|
Pubmed
|
4.521E-10
|
8.381E-9
|
6.002E-8
|
3.269E-7
|
3
|
10
|
40
|
20634891
|
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
|
Pubmed
|
9.821E-10
|
1.775E-8
|
1.271E-7
|
7.101E-7
|
5
|
331
|
41
|
1896463
|
Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions.
|
Pubmed
|
2.879E-8
|
2.169E-7
|
1.553E-6
|
2.082E-5
|
2
|
2
|
42
|
20357489
|
Immunoglobulin E sensitization to cross-reactive carbohydrate determinants: epidemiological study of clinical relevance and role of alcohol consumption.
|
Pubmed
|
2.879E-8
|
2.169E-7
|
1.553E-6
|
2.082E-5
|
2
|
2
|
43
|
9241435
|
Genetic mapping of a possible new alcohol dehydrogenase sequence to mouse chromosome 3 at the Adh-1/Adh-3 complex.
|
Pubmed
|
2.879E-8
|
2.169E-7
|
1.553E-6
|
2.082E-5
|
2
|
2
|
44
|
17295732
|
Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancer.
|
Pubmed
|
2.879E-8
|
2.169E-7
|
1.553E-6
|
2.082E-5
|
2
|
2
|
45
|
20494945
|
Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome.
|
Pubmed
|
2.879E-8
|
2.169E-7
|
1.553E-6
|
2.082E-5
|
2
|
2
|
46
|
20031627
|
Alcohol intake, myocardial infarction, biochemical risk factors, and alcohol dehydrogenase genotypes.
|
Pubmed
|
2.879E-8
|
2.169E-7
|
1.553E-6
|
2.082E-5
|
2
|
2
|
47
|
2893758
|
Molecular analysis of mouse alcohol dehydrogenase: nucleotide sequence of the Adh-1 gene and genetic mapping of a related nucleotide sequence to chromosome 3.
|
Pubmed
|
2.879E-8
|
2.169E-7
|
1.553E-6
|
2.082E-5
|
2
|
2
|
48
|
18761854
|
[Genetic variations in alcohol dehydrogenase, drinking habits and alcoholism].
|
Pubmed
|
2.879E-8
|
2.169E-7
|
1.553E-6
|
2.082E-5
|
2
|
2
|
49
|
16117582
|
Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college students.
|
Pubmed
|
2.879E-8
|
2.169E-7
|
1.553E-6
|
2.082E-5
|
2
|
2
|
50
|
11274460
|
Three-dimensional structures of the three human class I alcohol dehydrogenases.
|
Pubmed
|
2.879E-8
|
2.169E-7
|
1.553E-6
|
2.082E-5
|
2
|
2
|