Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc358_13, positive side

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1: GO: Molecular Function [Display Chart] 13 input genes in category / 48 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0051018 protein kinase A binding 1.828E-31 8.774E-30 3.912E-29 8.774E-30 12 47
2 GO:0034237 protein kinase A regulatory subunit binding 2.971E-13 7.130E-12 3.179E-11 1.426E-11 5 16
3 GO:0032947 protein-containing complex scaffold activity 7.348E-12 1.176E-10 5.242E-10 3.527E-10 6 78
4 GO:0008179 adenylate cyclase binding 2.945E-5 3.534E-4 1.576E-3 1.414E-3 2 12
5 GO:0034236 protein kinase A catalytic subunit binding 4.680E-5 4.493E-4 2.003E-3 2.246E-3 2 15
6 GO:0019903 protein phosphatase binding 1.167E-4 9.334E-4 4.162E-3 5.600E-3 3 142
7 GO:0019902 phosphatase binding 2.630E-4 1.804E-3 8.042E-3 1.262E-2 3 187
8 GO:0033149 FFAT motif binding 1.393E-3 8.357E-3 3.726E-2
6.686E-2
 1 2
9 GO:0044325 ion channel binding 3.413E-3 1.820E-2
8.115E-2
1.638E-1
 2 127
10 GO:0017151 DEAD/H-box RNA helicase binding 4.173E-3 1.876E-2
8.365E-2
2.003E-1
 1 6
11 GO:0004691 cAMP-dependent protein kinase activity 4.867E-3 1.876E-2
8.365E-2
2.336E-1
 1 7
12 GO:0008603 cAMP-dependent protein kinase regulator activity 5.561E-3 1.876E-2
8.365E-2
2.669E-1
 1 8
13 GO:0005078 MAP-kinase scaffold activity 5.561E-3 1.876E-2
8.365E-2
2.669E-1
 1 8
14 GO:0043495 protein membrane anchor 6.254E-3 1.876E-2
8.365E-2
3.002E-1
 1 9
15 GO:0030346 protein phosphatase 2B binding 6.254E-3 1.876E-2
8.365E-2
3.002E-1
 1 9
16 GO:0004862 cAMP-dependent protein kinase inhibitor activity 6.254E-3 1.876E-2
8.365E-2
3.002E-1
 1 9
17 GO:0008017 microtubule binding 9.395E-3 2.550E-2
1.137E-1
4.509E-1
 2 214
18 GO:0019207 kinase regulator activity 9.564E-3 2.550E-2
1.137E-1
4.591E-1
 2 216
19 GO:0005088 Ras guanyl-nucleotide exchange factor activity 1.097E-2 2.662E-2
1.187E-1
5.265E-1
 2 232
20 GO:0004690 cyclic nucleotide-dependent protein kinase activity 1.109E-2 2.662E-2
1.187E-1
5.324E-1
 1 16
21 GO:0008157 protein phosphatase 1 binding 1.522E-2 3.480E-2
1.551E-1
7.307E-1
 1 22
22 GO:0015631 tubulin binding 1.710E-2 3.581E-2
1.597E-1
8.206E-1
 2 293
23 GO:0030159 receptor signaling complex scaffold activity 1.797E-2 3.581E-2
1.597E-1
8.625E-1
 1 26
24 GO:0005085 guanyl-nucleotide exchange factor activity 1.855E-2 3.581E-2
1.597E-1
8.906E-1
 2 306
25 GO:0030552 cAMP binding 1.865E-2 3.581E-2
1.597E-1
8.953E-1
 1 27
26 GO:0030291 protein serine/threonine kinase inhibitor activity 2.071E-2 3.823E-2
1.704E-1
9.939E-1
 1 30
27 GO:0051721 protein phosphatase 2A binding 2.412E-2 4.134E-2
1.843E-1
1.000E0
 1 35
28 GO:0051059 NF-kappaB binding 2.412E-2 4.134E-2
1.843E-1
1.000E0
 1 35
29 GO:0030551 cyclic nucleotide binding 2.820E-2 4.512E-2
2.012E-1
1.000E0
 1 41
30 GO:0048487 beta-tubulin binding 2.820E-2 4.512E-2
2.012E-1
1.000E0
 1 41
Show 25 more annotations

2: GO: Biological Process [Display Chart] 13 input genes in category / 434 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0010738 regulation of protein kinase A signaling 1.144E-15 4.964E-13 3.302E-12 4.964E-13 6 20
2 GO:0010737 protein kinase A signaling 8.715E-15 1.891E-12 1.258E-11 3.782E-12 6 27
3 GO:0010611 regulation of cardiac muscle hypertrophy 3.227E-6 4.023E-4 2.676E-3 1.400E-3 3 43
4 GO:0014743 regulation of muscle hypertrophy 3.707E-6 4.023E-4 2.676E-3 1.609E-3 3 45
5 GO:0071320 cellular response to cAMP 5.758E-6 4.998E-4 3.324E-3 2.499E-3 3 52
6 GO:0003300 cardiac muscle hypertrophy 1.541E-5 9.098E-4 6.051E-3 6.689E-3 3 72
7 GO:0043502 regulation of muscle adaptation 1.674E-5 9.098E-4 6.051E-3 7.265E-3 3 74
8 GO:0014897 striated muscle hypertrophy 1.743E-5 9.098E-4 6.051E-3 7.565E-3 3 75
9 GO:0014896 muscle hypertrophy 1.887E-5 9.098E-4 6.051E-3 8.188E-3 3 77
10 GO:0043500 muscle adaptation 4.257E-5 1.847E-3 1.229E-2 1.847E-2 3 101
11 GO:2000479 regulation of cAMP-dependent protein kinase activity 4.699E-5 1.854E-3 1.233E-2 2.039E-2 2 15
12 GO:0051591 response to cAMP 5.345E-5 1.933E-3 1.286E-2 2.320E-2 3 109
13 GO:1901018 positive regulation of potassium ion transmembrane transporter activity 6.082E-5 2.030E-3 1.350E-2 2.639E-2 2 17
14 GO:0046683 response to organophosphorus 1.274E-4 3.951E-3 2.628E-2
5.531E-2
 3 146
15 GO:0060306 regulation of membrane repolarization 1.935E-4 5.279E-3 3.512E-2
8.399E-2
 2 30
16 GO:0014074 response to purine-containing compound 2.033E-4 5.279E-3 3.512E-2
8.824E-2
 3 171
17 GO:1901381 positive regulation of potassium ion transmembrane transport 2.068E-4 5.279E-3 3.512E-2
8.975E-2
 2 31
18 GO:0086009 membrane repolarization 2.955E-4 7.124E-3 4.739E-2
1.282E-1
 2 37
19 GO:0043268 positive regulation of potassium ion transport 3.997E-4 9.049E-3
6.019E-2
1.735E-1
 2 43
20 GO:0090257 regulation of muscle system process 4.205E-4 9.049E-3
6.019E-2
1.825E-1
 3 219
21 GO:1901016 regulation of potassium ion transmembrane transporter activity 4.379E-4 9.049E-3
6.019E-2
1.900E-1
 2 45
22 GO:0003015 heart process 8.512E-4 1.679E-2
1.117E-1
3.694E-1
 3 279
23 GO:1901379 regulation of potassium ion transmembrane transport 9.409E-4 1.775E-2
1.181E-1
4.083E-1
 2 66
24 GO:0032414 positive regulation of ion transmembrane transporter activity 1.345E-3 2.431E-2
1.617E-1
5.835E-1
 2 79
25 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 1.544E-3 2.681E-2
1.783E-1
6.702E-1
 3 343
26 GO:0032411 positive regulation of transporter activity 1.702E-3 2.733E-2
1.818E-1
7.388E-1
 2 89
27 GO:0043266 regulation of potassium ion transport 1.779E-3 2.733E-2
1.818E-1
7.719E-1
 2 91
28 GO:0007596 blood coagulation 1.817E-3 2.733E-2
1.818E-1
7.884E-1
 3 363
29 GO:0050817 coagulation 1.889E-3 2.733E-2
1.818E-1
8.198E-1
 3 368
30 GO:0007599 hemostasis 1.889E-3 2.733E-2
1.818E-1
8.198E-1
 3 368
31 GO:1900169 regulation of glucocorticoid mediated signaling pathway 2.093E-3 2.906E-2
1.933E-1
9.083E-1
 1 3
32 GO:0051153 regulation of striated muscle cell differentiation 2.142E-3 2.906E-2
1.933E-1
9.298E-1
 2 100
33 GO:0043402 glucocorticoid mediated signaling pathway 2.790E-3 3.451E-2
2.296E-1
1.000E0
 1 4
34 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway 2.790E-3 3.451E-2
2.296E-1
1.000E0
 1 4
35 GO:1904064 positive regulation of cation transmembrane transport 2.869E-3 3.451E-2
2.296E-1
1.000E0
 2 116
36 GO:0055007 cardiac muscle cell differentiation 2.917E-3 3.451E-2
2.296E-1
1.000E0
 2 117
37 GO:0003012 muscle system process 2.942E-3 3.451E-2
2.296E-1
1.000E0
 3 430
38 GO:0006171 cAMP biosynthetic process 3.426E-3 3.518E-2
2.340E-1
1.000E0
 2 127
39 GO:1902261 positive regulation of delayed rectifier potassium channel activity 3.486E-3 3.518E-2
2.340E-1
1.000E0
 1 5
40 GO:0044791 positive regulation by host of viral release from host cell 3.486E-3 3.518E-2
2.340E-1
1.000E0
 1 5
41 GO:2000481 positive regulation of cAMP-dependent protein kinase activity 3.486E-3 3.518E-2
2.340E-1
1.000E0
 1 5
42 GO:0044789 modulation by host of viral release from host cell 3.486E-3 3.518E-2
2.340E-1
1.000E0
 1 5
43 GO:1903818 positive regulation of voltage-gated potassium channel activity 3.486E-3 3.518E-2
2.340E-1
1.000E0
 1 5
44 GO:0044829 positive regulation by host of viral genome replication 4.182E-3 3.848E-2
2.560E-1
1.000E0
 1 6
45 GO:0086023 adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process 4.182E-3 3.848E-2
2.560E-1
1.000E0
 1 6
46 GO:0010739 positive regulation of protein kinase A signaling 4.182E-3 3.848E-2
2.560E-1
1.000E0
 1 6
47 GO:0007338 single fertilization 4.262E-3 3.848E-2
2.560E-1
1.000E0
 2 142
48 GO:0006913 nucleocytoplasmic transport 4.351E-3 3.848E-2
2.560E-1
1.000E0
 3 494
49 GO:0045860 positive regulation of protein kinase activity 4.401E-3 3.848E-2
2.560E-1
1.000E0
 3 496
50 GO:0035051 cardiocyte differentiation 4.439E-3 3.848E-2
2.560E-1
1.000E0
 2 145
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 13 input genes in category / 82 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005952 cAMP-dependent protein kinase complex 1.200E-5 9.836E-4 4.908E-3 9.836E-4 2 8
2 GO:0035686 sperm fibrous sheath 2.823E-5 1.157E-3 5.776E-3 2.315E-3 2 12
3 GO:0097228 sperm principal piece 1.078E-4 2.946E-3 1.470E-2 8.837E-3 2 23
4 GO:0030315 T-tubule 7.433E-4 1.524E-2
7.603E-2
6.095E-2
 2 60
5 GO:0036126 sperm flagellum 1.221E-3 1.780E-2
8.881E-2
1.001E-1
 2 77
6 GO:1902554 serine/threonine protein kinase complex 1.350E-3 1.780E-2
8.881E-2
1.107E-1
 2 81
7 GO:0044441 ciliary part 1.569E-3 1.780E-2
8.881E-2
1.287E-1
 3 353
8 GO:1902911 protein kinase complex 1.736E-3 1.780E-2
8.881E-2
1.424E-1
 2 92
9 GO:0044853 plasma membrane raft 2.253E-3 2.053E-2
1.025E-1
1.848E-1
 2 105
10 GO:0031514 motile cilium 3.584E-3 2.939E-2
1.467E-1
2.939E-1
 2 133
11 GO:0042383 sarcolemma 4.652E-3 3.287E-2
1.640E-1
3.814E-1
 2 152
12 GO:0001939 female pronucleus 5.444E-3 3.287E-2
1.640E-1
4.464E-1
 1 8
13 GO:0034703 cation channel complex 6.185E-3 3.287E-2
1.640E-1
5.071E-1
 2 176
14 GO:0097223 sperm part 6.741E-3 3.287E-2
1.640E-1
5.527E-1
 2 184
15 GO:0031588 nucleotide-activated protein kinase complex 6.801E-3 3.287E-2
1.640E-1
5.577E-1
 1 10
16 GO:0014701 junctional sarcoplasmic reticulum membrane 6.801E-3 3.287E-2
1.640E-1
5.577E-1
 1 10
17 GO:0070971 endoplasmic reticulum exit site 7.479E-3 3.287E-2
1.640E-1
6.132E-1
 1 11
18 GO:0030061 mitochondrial crista 7.479E-3 3.287E-2
1.640E-1
6.132E-1
 1 11
19 GO:0031968 organelle outer membrane 7.616E-3 3.287E-2
1.640E-1
6.245E-1
 2 196
20 GO:0019867 outer membrane 8.149E-3 3.341E-2
1.667E-1
6.682E-1
 2 203
21 GO:0061695 transferase complex, transferring phosphorus-containing groups 1.160E-2 4.529E-2
2.260E-1
9.511E-1
 2 244
Show 16 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 21 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001279 Syncope 4.117E-4 8.646E-3 3.152E-2 8.646E-3 2 96
2 HP:0011675 Arrhythmia 6.919E-3 4.897E-2
1.785E-1
1.453E-1
 2 392
3 HP:0030956 Abnormality of cardiovascular system electrophysiology 7.314E-3 4.897E-2
1.785E-1
1.536E-1
 2 403
4 HP:0001664 Torsade de pointes 9.327E-3 4.897E-2
1.785E-1
1.959E-1
 1 22

5: Mouse Phenotype [Display Chart] 9 input genes in category / 184 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 13 input genes in category / 78 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR018459 RII binding 1 InterPro 4.015E-16 1.566E-14 7.736E-14 3.132E-14 5 6
2 PF10522 RII binding 1 Pfam 4.015E-16 1.566E-14 7.736E-14 3.132E-14 5 6
3 IPR008382 SPHK1-interactor AKAP 110 InterPro 1.044E-9 2.035E-8 1.005E-7 8.140E-8 3 4
4 PF05716 AKAP 110 Pfam 1.044E-9 2.035E-8 1.005E-7 8.140E-8 3 4
5 IPR020799 AKAP 110 InterPro 4.445E-7 5.778E-6 2.855E-5 3.467E-5 2 2
6 SM00807 AKAP 110 SMART 4.445E-7 5.778E-6 2.855E-5 3.467E-5 2 2
7 IPR018292 AKAP 110 C InterPro 1.333E-6 1.485E-5 7.337E-5 1.040E-4 2 3
8 IPR030229 VAPA InterPro 6.939E-4 3.866E-3 1.910E-2
5.412E-2
 1 1
9 SM01188 ELK SMART 6.939E-4 3.866E-3 1.910E-2
5.412E-2
 1 1
10 IPR028852 AKAP13 InterPro 6.939E-4 3.866E-3 1.910E-2
5.412E-2
 1 1
11 IPR033104 Akap1 InterPro 6.939E-4 3.866E-3 1.910E-2
5.412E-2
 1 1
12 IPR005539 ELK dom InterPro 6.939E-4 3.866E-3 1.910E-2
5.412E-2
 1 1
13 IPR028745 AKAP9 InterPro 6.939E-4 3.866E-3 1.910E-2
5.412E-2
 1 1
14 IPR028540 AKAP12 InterPro 6.939E-4 3.866E-3 1.910E-2
5.412E-2
 1 1
15 IPR019528 PACT domain InterPro 1.387E-3 5.695E-3 2.814E-2
1.082E-1
 1 2
16 IPR026696 AKAP6/CEP68 InterPro 1.387E-3 5.695E-3 2.814E-2
1.082E-1
 1 2
17 PF10495 PACT coil coil Pfam 1.387E-3 5.695E-3 2.814E-2
1.082E-1
 1 2
18 IPR001573 Pkinase-A anch WSK-motif InterPro 1.387E-3 5.695E-3 2.814E-2
1.082E-1
 1 2
19 PF03832 WSK Pfam 1.387E-3 5.695E-3 2.814E-2
1.082E-1
 1 2
20 IPR016763 VAP InterPro 2.080E-3 6.491E-3 3.207E-2
1.623E-1
 1 3
21 PF04988 AKAP95 Pfam 2.080E-3 6.491E-3 3.207E-2
1.623E-1
 1 3
22 PS51799 ZF C2H2 AKAP95 PROSITE 2.080E-3 6.491E-3 3.207E-2
1.623E-1
 1 3
23 IPR007071 AKAP95 InterPro 2.080E-3 6.491E-3 3.207E-2
1.623E-1
 1 3
24 IPR029304 AKAP2 C InterPro 2.080E-3 6.491E-3 3.207E-2
1.623E-1
 1 3
25 PF15304 AKAP2 C Pfam 2.080E-3 6.491E-3 3.207E-2
1.623E-1
 1 3
26 IPR012198 cAMP dep PK reg su InterPro 2.773E-3 8.319E-3 4.110E-2
2.163E-1
 1 4
27 PF00635 Motile Sperm Pfam 3.465E-3 1.001E-2 4.945E-2
2.703E-1
 1 5
28 SM00394 RIIa SMART 4.157E-3 1.081E-2
5.339E-2
3.242E-1
 1 6
29 PS50202 MSP PROSITE 4.157E-3 1.081E-2
5.339E-2
3.242E-1
 1 6
30 IPR000535 MSP dom InterPro 4.157E-3 1.081E-2
5.339E-2
3.242E-1
 1 6
31 PF02197 RIIa Pfam 4.848E-3 1.220E-2
6.026E-2
3.781E-1
 1 7
32 2.60.40.360 - Gene3D 5.539E-3 1.350E-2
6.670E-2
4.320E-1
 1 8
33 IPR008962 PapD-like InterPro 6.919E-3 1.635E-2
8.079E-2
5.397E-1
 1 10
34 PF00567 TUDOR Pfam 9.674E-3 2.219E-2
1.096E-1
7.546E-1
 1 14
35 IPR003117 cAMP dep PK reg su I/II a/b InterPro 1.036E-2 2.309E-2
1.141E-1
8.082E-1
 1 15
36 IPR018488 cNMP-bd CS InterPro 1.105E-2 2.394E-2
1.183E-1
8.618E-1
 1 16
37 PS50304 TUDOR PROSITE 1.585E-2 3.341E-2
1.650E-1
1.000E0
 1 23
38 SM00333 TUDOR SMART 1.858E-2 3.814E-2
1.884E-1
1.000E0
 1 27
39 IPR002999 Tudor InterPro 2.062E-2 3.818E-2
1.886E-1
1.000E0
 1 30
40 IPR018159 Spectrin/alpha-actinin InterPro 2.199E-2 3.818E-2
1.886E-1
1.000E0
 1 32
41 SM00150 SPEC SMART 2.199E-2 3.818E-2
1.886E-1
1.000E0
 1 32
42 PS00888 CNMP BINDING 1 PROSITE 2.199E-2 3.818E-2
1.886E-1
1.000E0
 1 32
43 PS00889 CNMP BINDING 2 PROSITE 2.199E-2 3.818E-2
1.886E-1
1.000E0
 1 32
44 PF00027 cNMP binding Pfam 2.334E-2 3.818E-2
1.886E-1
1.000E0
 1 34
45 SM00100 cNMP SMART 2.334E-2 3.818E-2
1.886E-1
1.000E0
 1 34
46 IPR000595 cNMP-bd dom InterPro 2.402E-2 3.818E-2
1.886E-1
1.000E0
 1 35
47 SM00315 RGS SMART 2.402E-2 3.818E-2
1.886E-1
1.000E0
 1 35
48 PF00615 RGS Pfam 2.402E-2 3.818E-2
1.886E-1
1.000E0
 1 35
49 PS50042 CNMP BINDING 3 PROSITE 2.402E-2 3.818E-2
1.886E-1
1.000E0
 1 35
50 PS50132 RGS PROSITE 2.470E-2 3.818E-2
1.886E-1
1.000E0
 1 36
Show 45 more annotations

7: Pathway [Display Chart] 13 input genes in category / 138 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PW:0000543 protein kinase A (PKA) signaling Pathway Ontology 2.352E-29 3.246E-27 1.788E-26 3.246E-27 12 47
2 M5731 AKAP95 role in mitosis and chromosome dynamics MSigDB C2 BIOCARTA (v6.0) 6.604E-5 3.038E-3 1.673E-2 9.113E-3 2 12
3 M17668 Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation MSigDB C2 BIOCARTA (v6.0) 6.604E-5 3.038E-3 1.673E-2 9.113E-3 2 12
4 M15347 Protein Kinase A at the Centrosome MSigDB C2 BIOCARTA (v6.0) 1.049E-4 3.618E-3 1.993E-2 1.447E-2 2 15
5 1269377 Factors involved in megakaryocyte development and platelet production BioSystems: REACTOME 5.128E-4 1.415E-2
7.796E-2
7.076E-2
 3 157

8: Pubmed [Display Chart] 13 input genes in category / 731 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9238861 Anchoring and scaffold proteins for kinases and phosphatases. Pubmed 1.032E-28 7.545E-26 5.411E-25 7.545E-26 8 9
2 11807172 AKAP mediated signal transduction. Pubmed 5.160E-28 1.886E-25 1.353E-24 3.772E-25 8 10
3 12672969 Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Pubmed 8.357E-20 2.036E-17 1.461E-16 6.109E-17 6 10
4 17911601 Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin. Pubmed 3.987E-12 7.285E-10 5.225E-9 2.914E-9 4 12
5 10319321 Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. Pubmed 3.080E-11 3.753E-9 2.692E-8 2.252E-8 3 3
6 10413680 mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes. Pubmed 3.080E-11 3.753E-9 2.692E-8 2.252E-8 3 3
7 9497389 Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein. Pubmed 1.232E-10 1.286E-8 9.227E-8 9.005E-8 3 4
8 16642035 An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. Pubmed 6.157E-10 5.626E-8 4.035E-7 4.501E-7 3 6
9 12509440 Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. Pubmed 1.119E-8 9.087E-7 6.518E-6 8.179E-6 3 14
10 16956908 The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer. Pubmed 1.069E-7 4.599E-6 3.298E-5 7.818E-5 2 2
11 16260760 Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Pubmed 1.069E-7 4.599E-6 3.298E-5 7.818E-5 2 2
12 7929081 Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5. Pubmed 1.069E-7 4.599E-6 3.298E-5 7.818E-5 2 2
13 9473338 Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. Pubmed 1.069E-7 4.599E-6 3.298E-5 7.818E-5 2 2
14 8125992 Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase. Pubmed 1.069E-7 4.599E-6 3.298E-5 7.818E-5 2 2
15 24083380 Differential PKA activation and AKAP association determines cell fate in cancer cells. Pubmed 1.069E-7 4.599E-6 3.298E-5 7.818E-5 2 2
16 8621616 Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. Pubmed 1.069E-7 4.599E-6 3.298E-5 7.818E-5 2 2
17 9021145 Mapping of a haploid transcribed and translated sperm-specific gene to the mouse X chromosome. Pubmed 1.069E-7 4.599E-6 3.298E-5 7.818E-5 2 2
18 23455922 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Pubmed 2.530E-7 8.685E-6 6.229E-5 1.849E-4 5 446
19 11316952 Intracellular distribution of gravin, a PKA and PKC binding protein, in vascular endothelial cells. Pubmed 3.208E-7 8.685E-6 6.229E-5 2.345E-4 2 3
20 20581396 Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. Pubmed 3.208E-7 8.685E-6 6.229E-5 2.345E-4 2 3
21 23045525 Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart. Pubmed 3.208E-7 8.685E-6 6.229E-5 2.345E-4 2 3
22 10601332 The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis. Pubmed 3.208E-7 8.685E-6 6.229E-5 2.345E-4 2 3
23 25188285 PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation. Pubmed 3.208E-7 8.685E-6 6.229E-5 2.345E-4 2 3
24 12646697 Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Pubmed 3.208E-7 8.685E-6 6.229E-5 2.345E-4 2 3
25 17989356 Mitochondrial A-kinase anchoring protein 121 binds type II protein kinase A and enhances steroidogenic acute regulatory protein-mediated steroidogenesis in MA-10 mouse leydig tumor cells. Pubmed 3.208E-7 8.685E-6 6.229E-5 2.345E-4 2 3
26 9065479 Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. Pubmed 3.208E-7 8.685E-6 6.229E-5 2.345E-4 2 3
27 1618839 Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. Pubmed 3.208E-7 8.685E-6 6.229E-5 2.345E-4 2 3
28 11296225 mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. Pubmed 6.414E-7 1.302E-5 9.342E-5 4.689E-4 2 4
29 11823486 Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. Pubmed 6.414E-7 1.302E-5 9.342E-5 4.689E-4 2 4
30 17884635 Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Pubmed 6.414E-7 1.302E-5 9.342E-5 4.689E-4 2 4
31 11696326 Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation. Pubmed 6.414E-7 1.302E-5 9.342E-5 4.689E-4 2 4
32 9326583 D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Pubmed 6.414E-7 1.302E-5 9.342E-5 4.689E-4 2 4
33 24687590 Sperm-specific AKAP3 is a dual-specificity anchoring protein that interacts with both protein kinase a regulatory subunits via conserved N-terminal amphipathic peptides. Pubmed 6.414E-7 1.302E-5 9.342E-5 4.689E-4 2 4
34 9852104 Identification of tethering domains for protein kinase A type Ialpha regulatory subunits on sperm fibrous sheath protein FSC1. Pubmed 6.414E-7 1.302E-5 9.342E-5 4.689E-4 2 4
35 20731842 CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath. Pubmed 6.414E-7 1.302E-5 9.342E-5 4.689E-4 2 4
36 10764601 Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding. Pubmed 6.414E-7 1.302E-5 9.342E-5 4.689E-4 2 4
37 12606363 A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. Pubmed 1.069E-6 1.906E-5 1.367E-4 7.813E-4 2 5
38 18367160 Developmentally acquired PKA localisation in mouse oocytes and embryos. Pubmed 1.069E-6 1.906E-5 1.367E-4 7.813E-4 2 5
39 27484798 The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β. Pubmed 1.069E-6 1.906E-5 1.367E-4 7.813E-4 2 5
40 17683036 Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? Pubmed 1.069E-6 1.906E-5 1.367E-4 7.813E-4 2 5
41 10209101 Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220. Pubmed 1.069E-6 1.906E-5 1.367E-4 7.813E-4 2 5
42 12414807 AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. Pubmed 1.603E-6 2.604E-5 1.868E-4 1.172E-3 2 6
43 11278869 Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. Pubmed 1.603E-6 2.604E-5 1.868E-4 1.172E-3 2 6
44 15383279 AKAP-Lbc nucleates a protein kinase D activation scaffold. Pubmed 1.603E-6 2.604E-5 1.868E-4 1.172E-3 2 6
45 10358086 Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus. Pubmed 1.603E-6 2.604E-5 1.868E-4 1.172E-3 2 6
46 12147701 A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta. Pubmed 2.244E-6 3.490E-5 2.503E-4 1.640E-3 2 7
47 11799244 Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Pubmed 2.244E-6 3.490E-5 2.503E-4 1.640E-3 2 7
48 25097019 A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs. Pubmed 2.991E-6 4.462E-5 3.200E-4 2.186E-3 2 8
49 17923693 Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes. Pubmed 2.991E-6 4.462E-5 3.200E-4 2.186E-3 2 8
50 16687649 Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa. Pubmed 5.872E-6 8.585E-5 6.157E-4 4.292E-3 2 11
Show 45 more annotations

9: Interaction [Display Chart] 13 input genes in category / 560 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PRKAR2A PRKAR2A interactions 1.010E-28 5.658E-26 3.907E-25 5.658E-26 12 72
2 int:PRKAR2B PRKAR2B interactions 7.125E-17 1.995E-14 1.378E-13 3.990E-14 8 73
3 int:PRKAR1A PRKAR1A interactions 2.602E-11 4.856E-9 3.354E-8 1.457E-8 6 91
4 int:PRKACB PRKACB interactions 3.184E-9 4.457E-7 3.078E-6 1.783E-6 5 87
5 int:AKAP4 AKAP4 interactions 1.081E-8 1.211E-6 8.360E-6 6.053E-6 3 7
6 int:PRKACA PRKACA interactions 2.472E-8 2.308E-6 1.594E-5 1.385E-5 6 283
7 int:AKAP3 AKAP3 interactions 3.701E-8 2.961E-6 2.045E-5 2.073E-5 3 10
8 int:AKAP11 AKAP11 interactions 3.245E-6 2.188E-4 1.511E-3 1.817E-3 3 41
9 int:FGFR1OP FGFR1OP interactions 3.517E-6 2.188E-4 1.511E-3 1.969E-3 4 152
10 int:ROPN1L ROPN1L interactions 1.043E-5 5.842E-4 4.035E-3 5.842E-3 2 7
11 int:AMY1A AMY1A interactions 1.390E-5 7.078E-4 4.888E-3 7.786E-3 2 8
12 int:AKAP6 AKAP6 interactions 2.728E-5 1.273E-3 8.791E-3 1.528E-2 2 11
13 int:PDE4A PDE4A interactions 3.272E-5 1.309E-3 9.038E-3 1.832E-2 2 12
14 int:AKAP10 AKAP10 interactions 3.272E-5 1.309E-3 9.038E-3 1.832E-2 2 12
15 int:KCNQ1 KCNQ1 interactions 9.388E-5 3.505E-3 2.420E-2
5.257E-2
 2 20
16 int:PRKACG PRKACG interactions 1.602E-4 5.606E-3 3.872E-2
8.970E-2
 2 26
17 int:RYR2 RYR2 interactions 1.999E-4 6.584E-3 4.547E-2
1.119E-1
 2 29
18 int:AKAP2 AKAP2 interactions 2.439E-4 7.587E-3
5.239E-2
1.366E-1
 2 32
19 int:AMY1C AMY1C interactions 2.756E-4 8.123E-3
5.610E-2
1.543E-1
 2 34
20 int:AKAP13 AKAP13 interactions 3.092E-4 8.658E-3
5.980E-2
1.732E-1
 2 36
21 int:AKAP1 AKAP1 interactions 4.017E-4 1.022E-2
7.061E-2
2.249E-1
 2 41
22 int:AKAP12 AKAP12 interactions 4.017E-4 1.022E-2
7.061E-2
2.249E-1
 2 41
23 int:PRKAR1B PRKAR1B interactions 4.841E-4 1.179E-2
8.140E-2
2.711E-1
 2 45
24 int:PDE4D PDE4D interactions 5.059E-4 1.180E-2
8.152E-2
2.833E-1
 2 46
25 int:NPHS2 NPHS2 interactions 9.781E-4 2.191E-2
1.513E-1
5.477E-1
 2 64
26 int:PPP1CB PPP1CB interactions 1.069E-3 2.303E-2
1.590E-1
5.987E-1
 3 287
27 int:PCNT PCNT interactions 1.136E-3 2.338E-2
1.614E-1
6.361E-1
 2 69
28 int:GNA13 GNA13 interactions 1.169E-3 2.338E-2
1.614E-1
6.545E-1
 2 70
29 int:AKAP8 AKAP8 interactions 1.305E-3 2.520E-2
1.740E-1
7.308E-1
 2 74
30 int:STK4 STK4 interactions 1.449E-3 2.652E-2
1.832E-1
8.112E-1
 2 78
31 int:FSIP2 FSIP2 interactions 1.468E-3 2.652E-2
1.832E-1
8.222E-1
 1 2
32 int:CEP170P1 CEP170P1 interactions 1.922E-3 3.364E-2
2.323E-1
1.000E0
 2 90
33 int:CACNG1 CACNG1 interactions 2.202E-3 3.638E-2
2.512E-1
1.000E0
 1 3
34 int:PPP1CA PPP1CA interactions 2.216E-3 3.638E-2
2.512E-1
1.000E0
 3 370
35 int:AKAP9 AKAP9 interactions 2.274E-3 3.638E-2
2.512E-1
1.000E0
 2 98
36 int:ADGRG7 ADGRG7 interactions 2.934E-3 4.154E-2
2.869E-1
1.000E0
 1 4
37 int:PITPNM3 PITPNM3 interactions 2.934E-3 4.154E-2
2.869E-1
1.000E0
 1 4
38 int:FSIP1 FSIP1 interactions 2.934E-3 4.154E-2
2.869E-1
1.000E0
 1 4
39 int:IKZF3 IKZF3 interactions 2.957E-3 4.154E-2
2.869E-1
1.000E0
 2 112
40 int:FBXW11 FBXW11 interactions 2.967E-3 4.154E-2
2.869E-1
1.000E0
 3 410
41 int:PCTP PCTP interactions 3.667E-3 4.667E-2
3.223E-1
1.000E0
 1 5
42 int:ROPN1B ROPN1B interactions 3.667E-3 4.667E-2
3.223E-1
1.000E0
 1 5
43 int:CCDC127 CCDC127 interactions 3.667E-3 4.667E-2
3.223E-1
1.000E0
 1 5
44 int:KIF19 KIF19 interactions 3.667E-3 4.667E-2
3.223E-1
1.000E0
 1 5
Show 39 more annotations

10: Cytoband [Display Chart] 13 input genes in category / 13 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15q24-q25 15q24-q25 1.499E-3 9.736E-3 3.096E-2 1.949E-2 1 4
2 6q24-q25 6q24-q25 1.874E-3 9.736E-3 3.096E-2 2.436E-2 1 5
3 3p21.3-p21.2 3p21.3-p21.2 2.248E-3 9.736E-3 3.096E-2 2.923E-2 1 6
4 17p11.1 17p11.1 3.371E-3 9.736E-3 3.096E-2 4.382E-2 1 9
5 7q21-q22 7q21-q22 3.745E-3 9.736E-3 3.096E-2 4.868E-2 1 10
6 18p11.22 18p11.22 7.477E-3 1.458E-2 4.636E-2
9.720E-2
 1 20
7 Xp11.2 Xp11.2 7.849E-3 1.458E-2 4.636E-2
1.020E-1
 1 21
8 9q31.3 9q31.3 1.008E-2 1.617E-2
5.143E-2
1.311E-1
 1 27
9 12p13.3 12p13.3 1.120E-2 1.617E-2
5.143E-2
1.455E-1
 1 30
10 13q14.11 13q14.11 1.527E-2 1.935E-2
6.152E-2
1.985E-1
 1 41
11 17q22 17q22 1.712E-2 1.935E-2
6.152E-2
2.225E-1
 1 46
12 19p13.1 19p13.1 1.786E-2 1.935E-2
6.152E-2
2.321E-1
 1 48
13 14q12 14q12 2.080E-2 2.080E-2
6.616E-2
2.705E-1
 1 56
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 13 input genes in category / 94 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 11 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 396 A-kinase anchoring proteins genenames.org 3.025E-32 1.815E-31 4.446E-31 1.815E-31 11 30
2 694 Protein phosphatase 1 regulatory subunits genenames.org 1.507E-4 4.520E-4 1.107E-3 9.040E-4 3 181
3 780 RNA binding motif containing|Tudor domain containing genenames.org 2.215E-2 4.430E-2
1.085E-1
1.329E-1
 1 37
4 870 Minor histocompatibility antigens|FERM domain containing genenames.org 3.041E-2 4.562E-2
1.118E-1
1.825E-1
 1 51
5 722 Rho guanine nucleotide exchange factors genenames.org 3.920E-2 4.704E-2
1.152E-1
2.352E-1
 1 66

13: Coexpression [Display Chart] 13 input genes in category / 1348 annotations before applied cutoff / 23137 genes in category

No results to display

14: Coexpression Atlas [Display Chart] 13 input genes in category / 736 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingKidney e15.5 1000 k3 DevelopingKidney e15.5 anlage of loop of Henle emap-31283 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.649E-5 4.158E-2
2.985E-1
 4.158E-2 4 379

15: Computational [Display Chart] 8 input genes in category / 54 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 13 input genes in category / 684 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-4685-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.309E-7 4.544E-5 3.229E-4 8.955E-5 4 269
2 hsa-miR-4287:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.329E-7 4.544E-5 3.229E-4 9.089E-5 4 270
3 hsa-miR-219a-5p:TargetScan hsa-miR-219a-5p TargetScan 3.105E-7 7.079E-5 5.031E-4 2.124E-4 4 334
4 ACCATTT,MIR-522:MSigDB ACCATTT,MIR-522:MSigDB MSigDB 2.572E-6 4.398E-4 3.125E-3 1.759E-3 3 152
5 hsa-miR-219-5p:PITA hsa-miR-219-5p:PITA TOP PITA 3.727E-6 5.099E-4 3.623E-3 2.549E-3 3 172
6 hsa-miR-513b:PITA hsa-miR-513b:PITA TOP PITA 2.450E-5 2.793E-3 1.985E-2 1.676E-2 3 323
7 hsa-miR-204-5p:Functional MTI Functional MTI miRTarbase 4.590E-5 3.983E-3 2.830E-2 3.140E-2 3 399
8 hsa-miR-145:PITA hsa-miR-145:PITA TOP PITA 4.659E-5 3.983E-3 2.830E-2 3.186E-2 3 401
9 hsa-miR-7974:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.764E-5 5.141E-3 3.653E-2 4.627E-2 2 68
10 CAGGGTC,MIR-504:MSigDB CAGGGTC,MIR-504:MSigDB MSigDB 8.908E-5 5.539E-3 3.936E-2
6.093E-2
 2 78
11 hsa-miR-6505-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.908E-5 5.539E-3 3.936E-2
6.093E-2
 2 78
12 GTGTTGA,MIR-505:MSigDB GTGTTGA,MIR-505:MSigDB MSigDB 1.494E-4 8.337E-3
5.924E-2
1.022E-1
 2 101
13 hsa-miR-504:PITA hsa-miR-504:PITA TOP PITA 1.585E-4 8.337E-3
5.924E-2
1.084E-1
 2 104
14 hsa-miR-431-5p:TargetScan hsa-miR-431-5p TargetScan 1.805E-4 8.818E-3
6.266E-2
1.235E-1
 2 111
15 hsa-miR-656-3p:Functional MTI Functional MTI miRTarbase 2.252E-4 1.027E-2
7.296E-2
1.540E-1
 2 124
16 TCATCTC,MIR-143:MSigDB TCATCTC,MIR-143:MSigDB MSigDB 2.628E-4 1.124E-2
7.984E-2
1.798E-1
 2 134
17 hsa-miR-451b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.291E-4 1.242E-2
8.825E-2
2.251E-1
 2 150
18 hsa-miR-1302:PITA hsa-miR-1302:PITA TOP PITA 3.335E-4 1.242E-2
8.825E-2
2.281E-1
 2 151
19 hsa-miR-4719:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.468E-4 1.242E-2
8.825E-2
2.372E-1
 2 154
20 hsa-miR-1276:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.742E-4 1.242E-2
8.825E-2
2.559E-1
 2 160
21 hsa-miR-365:PITA hsa-miR-365:PITA TOP PITA 4.123E-4 1.242E-2
8.825E-2
2.820E-1
 2 168
22 hsa-miR-6083:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.626E-4 1.242E-2
8.825E-2
3.164E-1
 2 178
23 hsa-miR-106a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.834E-4 1.242E-2
8.825E-2
3.307E-1
 2 182
24 hsa-miR-575:PITA hsa-miR-575:PITA TOP PITA 5.156E-4 1.242E-2
8.825E-2
3.527E-1
 2 188
25 hsa-miR-557:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.156E-4 1.242E-2
8.825E-2
3.527E-1
 2 188
26 hsa-miR-1197:PITA hsa-miR-1197:PITA TOP PITA 5.156E-4 1.242E-2
8.825E-2
3.527E-1
 2 188
27 hsa-miR-507:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.156E-4 1.242E-2
8.825E-2
3.527E-1
 2 188
28 GGGACCA,MIR-133B:MSigDB GGGACCA,MIR-133B:MSigDB MSigDB 5.266E-4 1.242E-2
8.825E-2
3.602E-1
 2 190
29 GGGACCA,MIR-133A:MSigDB GGGACCA,MIR-133A:MSigDB MSigDB 5.266E-4 1.242E-2
8.825E-2
3.602E-1
 2 190
30 hsa-miR-299-5p:TargetScan hsa-miR-299-5p TargetScan 5.658E-4 1.290E-2
9.167E-2
3.870E-1
 2 197
31 hsa-miR-1303:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.888E-4 1.299E-2
9.232E-2
4.028E-1
 2 201
32 hsa-miR-760:PITA hsa-miR-760:PITA TOP PITA 6.423E-4 1.326E-2
9.419E-2
4.393E-1
 2 210
33 hsa-miR-329:PITA hsa-miR-329:PITA TOP PITA 6.730E-4 1.326E-2
9.419E-2
4.603E-1
 2 215
34 hsa-miR-362-3p:PITA hsa-miR-362-3p:PITA TOP PITA 6.730E-4 1.326E-2
9.419E-2
4.603E-1
 2 215
35 hsa-miR-5571-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.854E-4 1.326E-2
9.419E-2
4.688E-1
 2 217
36 hsa-miR-642a-5p:Functional MTI Functional MTI miRTarbase 7.300E-4 1.326E-2
9.419E-2
4.993E-1
 2 224
37 hsa-miR-3667-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.364E-4 1.326E-2
9.419E-2
5.037E-1
 2 225
38 AACTGGA,MIR-145:MSigDB AACTGGA,MIR-145:MSigDB MSigDB 7.364E-4 1.326E-2
9.419E-2
5.037E-1
 2 225
39 hsa-miR-769-5p:Non-Functional MTI Non-Functional MTI miRTarbase 7.626E-4 1.337E-2
9.504E-2
5.216E-1
 2 229
40 hsa-miR-518f:mirSVR highEffct hsa-miR-518f:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.300E-4 1.419E-2
1.009E-1
5.677E-1
 2 239
41 hsa-miR-936:PITA hsa-miR-936:PITA TOP PITA 9.730E-4 1.606E-2
1.141E-1
6.656E-1
 2 259
42 CACTGCC,MIR-34A:MSigDB CACTGCC,MIR-34A:MSigDB MSigDB 1.033E-3 1.606E-2
1.141E-1
7.068E-1
 2 267
43 CACTGCC,MIR-449:MSigDB CACTGCC,MIR-449:MSigDB MSigDB 1.033E-3 1.606E-2
1.141E-1
7.068E-1
 2 267
44 CACTGCC,MIR-34C:MSigDB CACTGCC,MIR-34C:MSigDB MSigDB 1.033E-3 1.606E-2
1.141E-1
7.068E-1
 2 267
45 hsa-miR-518c:mirSVR highEffct hsa-miR-518c:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.095E-3 1.652E-2
1.174E-1
7.493E-1
 2 275
46 hsa-miR-6077:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.127E-3 1.652E-2
1.174E-1
7.710E-1
 2 279
47 ACATTCC,MIR-206:MSigDB ACATTCC,MIR-206:MSigDB MSigDB 1.159E-3 1.652E-2
1.174E-1
7.929E-1
 2 283
48 ACATTCC,MIR-1:MSigDB ACATTCC,MIR-1:MSigDB MSigDB 1.159E-3 1.652E-2
1.174E-1
7.929E-1
 2 283
49 hsa-miR-1911:mirSVR highEffct hsa-miR-1911:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.250E-3 1.721E-2
1.223E-1
8.549E-1
 2 294
50 hsa-miR-1909*:mirSVR highEffct hsa-miR-1909*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.258E-3 1.721E-2
1.223E-1
8.607E-1
 2 295
Show 45 more annotations

17: Drug [Display Chart] 13 input genes in category / 3370 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID003036959 PDEs Stitch 2.510E-11 8.458E-8 7.358E-7 8.458E-8 6 116
2 CID000005092 rolipram Stitch 2.799E-9 4.716E-6 4.103E-5 9.432E-6 6 253
3 CID000000219 2-amino-3-ketobutyrate Stitch 2.895E-7 3.252E-4 2.829E-3 9.756E-4 3 24
4 CID000002534 NSC611747 Stitch 9.824E-7 8.277E-4 7.201E-3 3.311E-3 5 352
5 CID000003844 KT5720 Stitch 3.063E-6 2.064E-3 1.796E-2 1.032E-2 4 189
6 CID000100074 Kemptide Stitch 4.292E-5 2.411E-2
2.097E-1
1.447E-1
 3 124
7 CID000003541 AC1MBZ1C Stitch 5.140E-5 2.475E-2
2.153E-1
1.732E-1
 4 387
8 CID000058035 AC1L1O6Q Stitch 6.294E-5 2.651E-2
2.307E-1
2.121E-1
 3 141
9 7538 UP 11-deoxy-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.572E-4 3.319E-2
2.888E-1
5.297E-1
 3 192
10 7427 DN Econazole nitrate [24169-02-6]; Down 200; 9uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.596E-4 3.319E-2
2.888E-1
5.379E-1
 3 193
11 4987 UP Khellin [82-02-0]; Up 200; 15.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.621E-4 3.319E-2
2.888E-1
5.461E-1
 3 194
12 6233 DN Tetracycline hydrochloride [64-75-5]; Down 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.645E-4 3.319E-2
2.888E-1
5.545E-1
 3 195
13 4611 DN Tyloxapol [25301-02-4]; Down 200; 4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.645E-4 3.319E-2
2.888E-1
5.545E-1
 3 195
14 7139 DN Chrysene-1,4-quinone [100900-16-1]; Down 200; 15.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.670E-4 3.319E-2
2.888E-1
5.629E-1
 3 196
15 3603 DN Medrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.721E-4 3.319E-2
2.888E-1
5.800E-1
 3 198
16 6239 DN Phenethicillin potassium salt [132-93-4]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.747E-4 3.319E-2
2.888E-1
5.887E-1
 3 199
17 CID000129949 nitrobenzyl-DOTA Stitch 1.760E-4 3.319E-2
2.888E-1
5.933E-1
 2 35
18 6484 DN Urosiol [128-13-2]; Down 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.773E-4 3.319E-2
2.888E-1
5.975E-1
 3 200
Show 13 more annotations

18: Disease [Display Chart] 13 input genes in category / 53 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 OMIN:115080 CARDIAC CONDUCTION DEFECT OMIM 8.022E-4 8.504E-3 3.875E-2 4.252E-2 1 1
2 cv:C2678483 Long QT syndrome 11 Clinical Variations 8.022E-4 8.504E-3 3.875E-2 4.252E-2 1 1
3 OMIN:611820 LONG QT SYNDROME 11; LQT11 OMIM 8.022E-4 8.504E-3 3.875E-2 4.252E-2 1 1
4 C2678483 Long Qt Syndrome 11 DisGeNET Curated 8.022E-4 8.504E-3 3.875E-2 4.252E-2 1 1
5 cv:C0264886 Conduction disorder of the heart Clinical Variations 8.022E-4 8.504E-3 3.875E-2 4.252E-2 1 1