Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc35_9, positive side

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1: GO: Molecular Function [Display Chart] 9 input genes in category / 53 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0032296 double-stranded RNA-specific ribonuclease activity 9.286E-6 2.461E-4 1.121E-3 4.922E-4 2 10
2 GO:0004525 ribonuclease III activity 9.286E-6 2.461E-4 1.121E-3 4.922E-4 2 10
3 GO:0004519 endonuclease activity 5.684E-5 1.004E-3 4.576E-3 3.012E-3 3 167
4 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters 1.365E-4 1.558E-3 7.099E-3 7.235E-3 2 37
5 GO:0004518 nuclease activity 1.470E-4 1.558E-3 7.099E-3 7.789E-3 3 230
6 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.210E-4 1.952E-3 8.896E-3 1.171E-2 2 47
7 GO:0004521 endoribonuclease activity 3.255E-4 2.464E-3 1.123E-2 1.725E-2 2 57
8 GO:0003725 double-stranded RNA binding 4.633E-4 3.069E-3 1.399E-2 2.456E-2 2 68
9 GO:0004520 endodeoxyribonuclease activity 8.832E-4 5.103E-3 2.325E-2 4.681E-2 2 94
10 GO:0004530 deoxyribonuclease I activity 9.644E-4 5.103E-3 2.325E-2
5.111E-2
 1 2
11 GO:0004540 ribonuclease activity 1.059E-3 5.103E-3 2.325E-2
5.613E-2
 2 103
12 GO:0004536 deoxyribonuclease activity 1.185E-3 5.233E-3 2.385E-2
6.280E-2
 2 109
13 GO:0001069 regulatory region RNA binding 1.446E-3 5.896E-3 2.687E-2
7.665E-2
 1 3
14 GO:0070883 pre-miRNA binding 1.928E-3 7.299E-3 3.326E-2
1.022E-1
 1 4
15 GO:0015562 efflux transmembrane transporter activity 2.409E-3 7.981E-3 3.637E-2
1.277E-1
 1 5
16 GO:0070878 primary miRNA binding 2.409E-3 7.981E-3 3.637E-2
1.277E-1
 1 5
17 GO:0008559 xenobiotic transmembrane transporting ATPase activity 3.372E-3 1.021E-2 4.652E-2
1.787E-1
 1 7
18 GO:0035197 siRNA binding 3.853E-3 1.021E-2 4.652E-2
2.042E-1
 1 8
19 GO:0042910 xenobiotic transmembrane transporter activity 3.853E-3 1.021E-2 4.652E-2
2.042E-1
 1 8
20 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 3.853E-3 1.021E-2 4.652E-2
2.042E-1
 1 8
21 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 6.254E-3 1.578E-2
7.192E-2
3.314E-1
 1 13
22 GO:0035198 miRNA binding 8.171E-3 1.968E-2
8.970E-2
4.331E-1
 1 17
23 GO:0008187 poly-pyrimidine tract binding 1.056E-2 2.355E-2
1.073E-1
5.598E-1
 1 22
24 GO:0001530 lipopolysaccharide binding 1.104E-2 2.355E-2
1.073E-1
5.851E-1
 1 23
25 GO:0004697 protein kinase C activity 1.152E-2 2.355E-2
1.073E-1
6.105E-1
 1 24
26 GO:0015238 drug transmembrane transporter activity 1.200E-2 2.355E-2
1.073E-1
6.358E-1
 1 25
27 GO:0036002 pre-mRNA binding 1.200E-2 2.355E-2
1.073E-1
6.358E-1
 1 25
28 GO:0016303 1-phosphatidylinositol-3-kinase activity 2.055E-2 3.890E-2
1.773E-1
1.000E0
 1 43
29 GO:0005070 SH3/SH2 adaptor activity 2.575E-2 4.706E-2
2.144E-1
1.000E0
 1 54
30 GO:0052742 phosphatidylinositol kinase activity 2.763E-2 4.882E-2
2.225E-1
1.000E0
 1 58
Show 25 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 454 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016441 posttranscriptional gene silencing 2.503E-6 4.099E-4 2.745E-3 1.136E-3 3 59
2 GO:0035194 posttranscriptional gene silencing by RNA 2.503E-6 4.099E-4 2.745E-3 1.136E-3 3 59
3 GO:0030422 production of siRNA involved in RNA interference 3.111E-6 4.099E-4 2.745E-3 1.412E-3 2 6
4 GO:0006401 RNA catabolic process 3.612E-6 4.099E-4 2.745E-3 1.640E-3 4 247
5 GO:2000628 regulation of miRNA metabolic process 7.461E-6 6.775E-4 4.537E-3 3.387E-3 2 9
6 GO:0006417 regulation of translation 1.386E-5 1.000E-3 6.697E-3 6.294E-3 4 347
7 GO:0016246 RNA interference 1.884E-5 1.000E-3 6.697E-3 8.552E-3 2 14
8 GO:0031054 pre-miRNA processing 1.884E-5 1.000E-3 6.697E-3 8.552E-3 2 14
9 GO:0034248 regulation of cellular amide metabolic process 1.983E-5 1.000E-3 6.697E-3 9.001E-3 4 380
10 GO:0034655 nucleobase-containing compound catabolic process 2.883E-5 1.197E-3 8.015E-3 1.309E-2 4 418
11 GO:0010586 miRNA metabolic process 3.164E-5 1.197E-3 8.015E-3 1.436E-2 2 18
12 GO:0016075 rRNA catabolic process 3.164E-5 1.197E-3 8.015E-3 1.436E-2 2 18
13 GO:0044270 cellular nitrogen compound catabolic process 4.267E-5 1.246E-3 8.344E-3 1.937E-2 4 462
14 GO:0046700 heterocycle catabolic process 4.340E-5 1.246E-3 8.344E-3 1.970E-2 4 464
15 GO:0019439 aromatic compound catabolic process 4.717E-5 1.246E-3 8.344E-3 2.142E-2 4 474
16 GO:0010608 posttranscriptional regulation of gene expression 4.756E-5 1.246E-3 8.344E-3 2.159E-2 4 475
17 GO:0045589 regulation of regulatory T cell differentiation 4.772E-5 1.246E-3 8.344E-3 2.166E-2 2 22
18 GO:0031047 gene silencing by RNA 4.940E-5 1.246E-3 8.344E-3 2.243E-2 3 159
19 GO:0034661 ncRNA catabolic process 6.193E-5 1.406E-3 9.413E-3 2.811E-2 2 25
20 GO:0045066 regulatory T cell differentiation 6.193E-5 1.406E-3 9.413E-3 2.811E-2 2 25
21 GO:0035196 production of miRNAs involved in gene silencing by miRNA 9.584E-5 2.017E-3 1.351E-2 4.351E-2 2 31
22 GO:0070918 production of small RNA involved in gene silencing by RNA 1.022E-4 2.017E-3 1.351E-2 4.640E-2 2 32
23 GO:0031050 dsRNA processing 1.022E-4 2.017E-3 1.351E-2 4.640E-2 2 32
24 GO:0048255 mRNA stabilization 1.297E-4 2.453E-3 1.643E-2
5.888E-2
 2 36
25 GO:0043489 RNA stabilization 1.371E-4 2.489E-3 1.667E-2
6.223E-2
 2 37
26 GO:0016458 gene silencing 2.028E-4 3.542E-3 2.372E-2
9.209E-2
 3 256
27 GO:0040029 regulation of gene expression, epigenetic 2.246E-4 3.777E-3 2.529E-2
1.020E-1
 3 265
28 GO:0071359 cellular response to dsRNA 2.413E-4 3.912E-3 2.620E-2
1.095E-1
 2 49
29 GO:0035195 gene silencing by miRNA 3.042E-4 4.763E-3 3.189E-2
1.381E-1
 2 55
30 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 4.652E-4 5.774E-3 3.866E-2
2.112E-1
 2 68
31 GO:0071387 cellular response to cortisol stimulus 4.833E-4 5.774E-3 3.866E-2
2.194E-1
 1 1
32 GO:1990141 chromatin silencing at centromere outer repeat region 4.833E-4 5.774E-3 3.866E-2
2.194E-1
 1 1
33 GO:0033168 conversion of ds siRNA to ss siRNA involved in RNA interference 4.833E-4 5.774E-3 3.866E-2
2.194E-1
 1 1
34 GO:1904409 regulation of secretory granule organization 4.833E-4 5.774E-3 3.866E-2
2.194E-1
 1 1
35 GO:0048058 compound eye corneal lens development 4.833E-4 5.774E-3 3.866E-2
2.194E-1
 1 1
36 GO:0030702 chromatin silencing at centromere 4.833E-4 5.774E-3 3.866E-2
2.194E-1
 1 1
37 GO:0036404 conversion of ds siRNA to ss siRNA 4.833E-4 5.774E-3 3.866E-2
2.194E-1
 1 1
38 GO:1904411 positive regulation of secretory granule organization 4.833E-4 5.774E-3 3.866E-2
2.194E-1
 1 1
39 GO:0043331 response to dsRNA 7.259E-4 8.450E-3
5.659E-2
3.296E-1
 2 85
40 GO:0014040 positive regulation of Schwann cell differentiation 9.663E-4 1.045E-2
6.995E-2
4.387E-1
 1 2
41 GO:0048749 compound eye development 9.663E-4 1.045E-2
6.995E-2
4.387E-1
 1 2
42 GO:0010070 zygote asymmetric cell division 9.663E-4 1.045E-2
6.995E-2
4.387E-1
 1 2
43 GO:0050684 regulation of mRNA processing 1.233E-3 1.302E-2
8.720E-2
5.599E-1
 2 111
44 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration 1.449E-3 1.400E-2
9.374E-2
6.579E-1
 1 3
45 GO:0032290 peripheral nervous system myelin formation 1.449E-3 1.400E-2
9.374E-2
6.579E-1
 1 3
46 GO:0014038 regulation of Schwann cell differentiation 1.449E-3 1.400E-2
9.374E-2
6.579E-1
 1 3
47 GO:0030423 targeting of mRNA for destruction involved in RNA interference 1.449E-3 1.400E-2
9.374E-2
6.579E-1
 1 3
48 GO:1903311 regulation of mRNA metabolic process 1.686E-3 1.562E-2
1.046E-1
7.654E-1
 2 130
49 GO:0090501 RNA phosphodiester bond hydrolysis 1.686E-3 1.562E-2
1.046E-1
7.654E-1
 2 130
50 GO:0045580 regulation of T cell differentiation 1.790E-3 1.625E-2
1.088E-1
8.126E-1
 2 134
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 23 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1902555 endoribonuclease complex 4.142E-5 9.528E-4 3.558E-3 9.528E-4 2 21
2 GO:0033167 ARC complex 4.722E-4 5.429E-3 2.027E-2 1.086E-2 1 1
3 GO:0070877 microprocessor complex 9.441E-4 5.429E-3 2.027E-2 2.172E-2 1 2
4 GO:1903095 ribonuclease III complex 9.441E-4 5.429E-3 2.027E-2 2.172E-2 1 2
5 GO:0070578 RISC-loading complex 2.830E-3 1.265E-2 4.725E-2
6.509E-2
 1 6
6 GO:0035068 micro-ribonucleoprotein complex 3.301E-3 1.265E-2 4.725E-2
7.592E-2
 1 7
7 GO:0031332 RNAi effector complex 5.183E-3 1.490E-2
5.564E-2
1.192E-1
 1 11
8 GO:0016442 RISC complex 5.183E-3 1.490E-2
5.564E-2
1.192E-1
 1 11
Show 3 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 146 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000866 Euthyroid multinodular goiter 8.497E-4 3.101E-2
1.725E-1
1.241E-1
 1 2
2 HP:0030071 Medulloepithelioma 8.497E-4 3.101E-2
1.725E-1
1.241E-1
 1 2
3 HP:0030070 Central primitive neuroectodermal tumor 8.497E-4 3.101E-2
1.725E-1
1.241E-1
 1 2
4 HP:0010465 Precocious puberty in females 1.274E-3 3.101E-2
1.725E-1
1.861E-1
 1 3
5 HP:0100528 Pleuropulmonary blastoma 1.274E-3 3.101E-2
1.725E-1
1.861E-1
 1 3
6 HP:0100619 Sertoli cell neoplasm 1.699E-3 3.101E-2
1.725E-1
2.481E-1
 1 4
7 HP:0009798 Euthyroid goiter 1.699E-3 3.101E-2
1.725E-1
2.481E-1
 1 4
8 HP:0030434 Pilomatrixoma 1.699E-3 3.101E-2
1.725E-1
2.481E-1
 1 4
9 HP:0100813 Testicular torsion 2.124E-3 3.445E-2
1.917E-1
3.100E-1
 1 5
10 HP:0010314 Premature thelarche 2.548E-3 3.720E-2
2.070E-1
3.720E-1
 1 6
11 HP:0011672 Cardiac myxoma 2.972E-3 3.945E-2
2.195E-1
4.340E-1
 1 7
12 HP:0100617 Testicular seminoma 3.397E-3 4.133E-2
2.299E-1
4.959E-1
 1 8
13 HP:0012842 Skin appendage neoplasm 4.245E-3 4.647E-2
2.586E-1
6.198E-1
 1 10
14 HP:0200063 Colorectal polyposis 5.093E-3 4.647E-2
2.586E-1
7.436E-1
 1 12
15 HP:0100768 Choriocarcinoma 5.093E-3 4.647E-2
2.586E-1
7.436E-1
 1 12
16 HP:0031502 Trophoblastic tumor 5.093E-3 4.647E-2
2.586E-1
7.436E-1
 1 12
Show 11 more annotations

5: Mouse Phenotype [Display Chart] 9 input genes in category / 633 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0009759 abnormal hair follicle bulge morphology 6.078E-5 1.436E-2
1.009E-1
 3.847E-2 2 14
2 MP:0008859 abnormal hair cycle catagen phase 7.010E-5 1.436E-2
1.009E-1
 4.437E-2 2 15
3 MP:0000380 small hair follicles 8.008E-5 1.436E-2
1.009E-1
5.069E-2
 2 16
4 MP:0003875 abnormal hair follicle regression 9.071E-5 1.436E-2
1.009E-1
5.742E-2
 2 17
5 MP:0010685 abnormal hair follicle inner root sheath morphology 1.537E-4 1.946E-2
1.368E-1
9.731E-2
 2 22
6 MP:0003413 hair follicle degeneration 2.693E-4 2.608E-2
1.833E-1
1.705E-1
 2 29
7 MP:0000410 waved hair 2.885E-4 2.608E-2
1.833E-1
1.826E-1
 2 30
8 MP:0010684 abnormal hair follicle outer root sheath morphology 3.713E-4 2.938E-2
2.065E-1
2.351E-1
 2 34
9 MP:0003853 dry skin 5.679E-4 3.587E-2
2.521E-1
3.595E-1
 2 42
10 MP:0001863 vascular inflammation 5.953E-4 3.587E-2
2.521E-1
3.768E-1
 2 43
11 MP:0008346 increased gamma-delta T cell number 6.234E-4 3.587E-2
2.521E-1
3.946E-1
 2 44
12 MP:0014194 increased epididymal epithelium cell proliferation 8.691E-4 4.211E-2
2.960E-1
5.502E-1
 1 1
13 MP:0014192 increased epididymal cell proliferation 8.691E-4 4.211E-2
2.960E-1
5.502E-1
 1 1
14 MP:0000377 abnormal hair follicle morphology 9.314E-4 4.211E-2
2.960E-1
5.896E-1
 3 240
Show 9 more annotations

6: Domain [Display Chart] 9 input genes in category / 80 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1.10.1520.10 - Gene3D 6.153E-7 8.204E-6 4.073E-5 4.922E-5 2 3
2 PS50142 RNASE 3 2 PROSITE 6.153E-7 8.204E-6 4.073E-5 4.922E-5 2 3
3 SM00535 RIBOc SMART 6.153E-7 8.204E-6 4.073E-5 4.922E-5 2 3
4 IPR000999 RNase III dom InterPro 6.153E-7 8.204E-6 4.073E-5 4.922E-5 2 3
5 PS00517 RNASE 3 1 PROSITE 6.153E-7 8.204E-6 4.073E-5 4.922E-5 2 3
6 PF00636 Ribonuclease 3 Pfam 6.153E-7 8.204E-6 4.073E-5 4.922E-5 2 3
7 SM00358 DSRM SMART 3.493E-5 3.811E-4 1.892E-3 2.794E-3 2 19
8 PF00035 dsrm Pfam 3.880E-5 3.811E-4 1.892E-3 3.104E-3 2 20
9 PS50137 DS RBD PROSITE 4.288E-5 3.811E-4 1.892E-3 3.430E-3 2 21
10 3.30.160.20 - Gene3D 7.156E-5 5.603E-4 2.782E-3 5.725E-3 2 27
11 IPR014720 dsRBD dom InterPro 7.704E-5 5.603E-4 2.782E-3 6.163E-3 2 28
12 PS51327 DICER DSRBF PROSITE 4.804E-4 2.261E-3 1.123E-2 3.843E-2 1 1
13 IPR005034 Dicer dimerisation dom InterPro 4.804E-4 2.261E-3 1.123E-2 3.843E-2 1 1
14 PF14622 Ribonucleas 3 3 Pfam 4.804E-4 2.261E-3 1.123E-2 3.843E-2 1 1
15 IPR033500 TNRC6B InterPro 4.804E-4 2.261E-3 1.123E-2 3.843E-2 1 1
16 PF03368 Dicer dimer Pfam 4.804E-4 2.261E-3 1.123E-2 3.843E-2 1 1
17 IPR011907 RNase III InterPro 4.804E-4 2.261E-3 1.123E-2 3.843E-2 1 1
18 IPR032226 TNRC6 PABC-bd InterPro 1.441E-3 5.488E-3 2.725E-2
1.152E-1
 1 3
19 PF16608 TNRC6-PABC bdg Pfam 1.441E-3 5.488E-3 2.725E-2
1.152E-1
 1 3
20 IPR019486 Argonaute hook dom InterPro 1.441E-3 5.488E-3 2.725E-2
1.152E-1
 1 3
21 PF10427 Ago hook Pfam 1.441E-3 5.488E-3 2.725E-2
1.152E-1
 1 3
22 1.10.287.160 - Gene3D 2.400E-3 8.347E-3 4.145E-2
1.920E-1
 1 5
23 IPR006536 HnRNP-L/PTB InterPro 2.400E-3 8.347E-3 4.145E-2
1.920E-1
 1 5
24 SM00742 Hr1 SMART 3.358E-3 1.119E-2
5.559E-2
2.687E-1
 1 7
25 PF02185 HR1 Pfam 3.837E-3 1.191E-2
5.912E-2
3.070E-1
 1 8
26 IPR003100 PAZ dom InterPro 4.316E-3 1.191E-2
5.912E-2
3.453E-1
 1 9
27 PF02170 PAZ Pfam 4.316E-3 1.191E-2
5.912E-2
3.453E-1
 1 9
28 SM00949 PAZ SMART 4.316E-3 1.191E-2
5.912E-2
3.453E-1
 1 9
29 PS50821 PAZ PROSITE 4.316E-3 1.191E-2
5.912E-2
3.453E-1
 1 9
30 PS50102 RRM PROSITE 5.104E-3 1.361E-2
6.758E-2
4.083E-1
 2 230
31 3.30.70.330 - Gene3D 5.725E-3 1.478E-2
7.337E-2
4.580E-1
 2 244
32 IPR012677 Nucleotide-bd a/b plait InterPro 6.380E-3 1.595E-2
7.920E-2
5.104E-1
 2 258
33 PF01576 Myosin tail 1 Pfam 8.616E-3 2.027E-2
1.007E-1
6.892E-1
 1 18
34 IPR002928 Myosin tail InterPro 8.616E-3 2.027E-2
1.007E-1
6.892E-1
 1 18
35 PF00664 ABC membrane Pfam 1.147E-2 2.622E-2
1.302E-1
9.178E-1
 1 24
36 IPR011072 HR1 rho-bd InterPro 1.195E-2 2.655E-2
1.318E-1
9.559E-1
 1 25
37 PS50929 ABC TM1F PROSITE 1.337E-2 2.815E-2
1.398E-1
1.000E0
 1 28
38 IPR011527 ABC1 TM dom InterPro 1.337E-2 2.815E-2
1.398E-1
1.000E0
 1 28
39 IPR017892 Pkinase C InterPro 1.764E-2 3.618E-2
1.797E-1
1.000E0
 1 37
40 IPR017871 ABC transporter CS InterPro 2.000E-2 3.903E-2
1.938E-1
1.000E0
 1 42
41 PF00433 Pkinase C Pfam 2.000E-2 3.903E-2
1.938E-1
1.000E0
 1 42
42 PS50893 ABC TRANSPORTER 2 PROSITE 2.283E-2 4.226E-2
2.098E-1
1.000E0
 1 48
43 PF00005 ABC tran Pfam 2.283E-2 4.226E-2
2.098E-1
1.000E0
 1 48
44 PS00211 ABC TRANSPORTER 1 PROSITE 2.330E-2 4.226E-2
2.098E-1
1.000E0
 1 49
45 IPR003439 ABC transporter-like InterPro 2.377E-2 4.226E-2
2.098E-1
1.000E0
 1 50
46 SM00133 S TK X SMART 2.659E-2 4.431E-2
2.200E-1
1.000E0
 1 56
47 PS51285 AGC KINASE CTER PROSITE 2.659E-2 4.431E-2
2.200E-1
1.000E0
 1 56
48 IPR000961 AGC-kinase C InterPro 2.659E-2 4.431E-2
2.200E-1
1.000E0
 1 56
49 IPR009060 UBA-like InterPro 3.033E-2 4.953E-2
2.459E-1
1.000E0
 1 64
Show 44 more annotations

7: Pathway [Display Chart] 8 input genes in category / 127 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269719 Gene Silencing by RNA BioSystems: REACTOME 7.165E-5 6.832E-3 3.707E-2 9.099E-3 3 138
2 1269720 MicroRNA (miRNA) biogenesis BioSystems: REACTOME 1.076E-4 6.832E-3 3.707E-2 1.366E-2 2 25
3 1269399 Signaling by FGFR2 BioSystems: REACTOME 9.794E-4 4.146E-2
2.249E-1
1.244E-1
 2 75
4 1269386 Signaling by FGFR BioSystems: REACTOME 1.376E-3 4.368E-2
2.370E-1
1.747E-1
 2 89
5 1269188 PIP3 activates AKT signaling BioSystems: REACTOME 2.692E-3 4.548E-2
2.467E-1
3.418E-1
 2 125
6 1269384 GAB1 signalosome BioSystems: REACTOME 2.820E-3 4.548E-2
2.467E-1
3.581E-1
 2 128
7 1269473 PI3K/AKT activation BioSystems: REACTOME 2.820E-3 4.548E-2
2.467E-1
3.581E-1
 2 128
8 1457798 MET activates PTPN11 BioSystems: REACTOME 3.209E-3 4.548E-2
2.467E-1
4.076E-1
 1 5
9 1269302 Role of LAT2/NTAL/LAB on calcium mobilization BioSystems: REACTOME 3.223E-3 4.548E-2
2.467E-1
4.093E-1
 2 137
10 1457797 MET activates PI3K/AKT signaling BioSystems: REACTOME 3.850E-3 4.711E-2
2.556E-1
4.890E-1
 1 6
11 1269722 Post-transcriptional silencing by small RNAs BioSystems: REACTOME 4.490E-3 4.711E-2
2.556E-1
5.703E-1
 1 7
12 1269721 Small interfering RNA (siRNA) biogenesis BioSystems: REACTOME 5.770E-3 4.711E-2
2.556E-1
7.328E-1
 1 9
13 1457804 MET receptor recycling BioSystems: REACTOME 6.409E-3 4.711E-2
2.556E-1
8.140E-1
 1 10
14 1383048 Signaling by FGFR3 fusions in cancer BioSystems: REACTOME 6.409E-3 4.711E-2
2.556E-1
8.140E-1
 1 10
15 1269185 Downstream signaling events of B Cell Receptor (BCR) BioSystems: REACTOME 6.681E-3 4.711E-2
2.556E-1
8.485E-1
 2 199
16 782000 Proteoglycans in cancer BioSystems: KEGG 6.944E-3 4.711E-2
2.556E-1
8.819E-1
 2 203
17 PW:0000578 scatter factor/hepatocyte growth factor signaling Pathway Ontology 7.048E-3 4.711E-2
2.556E-1
8.952E-1
 1 11
18 1268877 Signaling by FGFR4 in disease BioSystems: REACTOME 7.048E-3 4.711E-2
2.556E-1
8.952E-1
 1 11
19 1457802 MET activates RAP1 and RAC1 BioSystems: REACTOME 7.048E-3 4.711E-2
2.556E-1
8.952E-1
 1 11
Show 14 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 1544 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 25867481 Sequence features of Drosha and Dicer cleavage sites affect the complexity of isomiRs. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
2 20713509 Canonical and alternate functions of the microRNA biogenesis machinery. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
3 24725360 The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
4 27808570 DICER and DROSHA gene expression and polymorphisms in autoimmune thyroid diseases. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
5 25190313 Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
6 26773046 Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
7 22379031 Dynamic microRNA gene transcription and processing during T cell development. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
8 21559780 Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
9 26921501 siRNA release from pri-miRNA scaffolds is controlled by the sequence and structure of RNA. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
10 17060477 A role for Dicer in immune regulation. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
11 22434867 Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
12 29892896 Association of rs1057035polymorphism in microRNA biogenesis pathway gene (DICER1) with azoospermia among Iranian population. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
13 20210522 Expression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancer. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
14 21788498 Male germ cells express abundant endogenous siRNAs. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
15 20805302 microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
16 21898071 Dysregulated expression of dicer and drosha in breast cancer. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
17 26718009 Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
18 23349018 DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
19 22665486 The RNase III enzyme DROSHA is essential for microRNA production and spermatogenesis. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
20 15987463 Alternative initiation and splicing in dicer gene expression in human breast cells. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
21 21544061 The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
22 18434510 Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
23 28448850 Perturbation of DROSHA and DICER expression by human papillomavirus 16 oncoproteins. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
24 24990804 Murine follicular development requires oocyte DICER, but not DROSHA. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
25 26437240 Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
26 26906421 DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
27 22381205 Genetic variants in microRNA biogenesis pathway genes are associated with semen quality in a Han-Chinese population. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
28 21953080 The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
29 25295740 Upregulation of microRNA processing enzymes Drosha and Dicer in gestational diabetes mellitus. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
30 23266047 Dicer and Drosha expression and response to Bevacizumab-based therapy in advanced colorectal cancer patients. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
31 26156018 High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
32 22479364 Knock-down of core proteins regulating microRNA biogenesis has no effect on sensitivity of lung cancer cells to ionizing radiation. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
33 19092150 Dicer, Drosha, and outcomes in patients with ovarian cancer. Pubmed 4.936E-8 2.309E-6 1.829E-5 7.621E-5 2 2
34 27173348 Drosha, DGCR8, and Dicer mRNAs are down-regulated in human cells infected with dengue virus 4, and play a role in viral pathogenesis. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
35 22766726 Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
36 22371183 Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
37 17679093 The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
38 21769619 Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
39 26976605 Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
40 24938790 MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
41 23663110 Expression of genes for microRNA-processing enzymes is altered in advanced non-alcoholic fatty liver disease. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
42 27545503 Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
43 28388279 Investigation of AID, Dicer, and Drosha Expressions in Patients with Chronic Lymphocytic Leukemia. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
44 22706270 Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
45 25656609 EIF2C, Dicer, and Drosha are up-regulated along tumor progression and associated with poor prognosis in bladder carcinoma. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
46 25439752 Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
47 22394132 Immunohistochemical analysis of the endoribonucleases Drosha, Dicer and Ago2 in smooth muscle tumours of soft tissues. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
48 24769857 Genetic variants in microRNA machinery genes are associated [corrected] with idiopathic recurrent pregnancy loss risk. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
49 26227789 Expression of the microRNA regulators Drosha, Dicer and Ago2 in non-small cell lung carcinomas. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
50 24574065 Complexity in regulation of microRNA machinery components in invasive breast carcinoma. Pubmed 1.481E-7 4.572E-6 3.621E-5 2.286E-4 2 3
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 586 annotations before applied cutoff / 17703 genes in category

No results to display

10: Cytoband [Display Chart] 9 input genes in category / 9 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14q32.13 14q32.13 4.923E-3 1.573E-2 4.449E-2 4.431E-2 1 19
2 7p21.1 7p21.1 5.699E-3 1.573E-2 4.449E-2
5.129E-2
 1 22
3 5p13.3 5p13.3 6.473E-3 1.573E-2 4.449E-2
5.826E-2
 1 25
4 4q31.21 4q31.21 6.990E-3 1.573E-2 4.449E-2
6.291E-2
 1 27
5 9q13 9q13 9.310E-3 1.676E-2 4.741E-2
8.379E-2
 1 36
6 9q34.11 9q34.11 1.522E-2 2.283E-2
6.458E-2
1.370E-1
 1 59
7 22q13.1 22q13.1 2.288E-2 2.688E-2
7.604E-2
2.059E-1
 1 89
8 1q21 1q21 2.389E-2 2.688E-2
7.604E-2
2.150E-1
 1 93
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 54 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 7 input genes in category / 8 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 835 C2 domain containing protein kinases genenames.org 3.842E-3 1.127E-2 3.062E-2 3.073E-2 1 10
2 1168 RNA helicases genenames.org 4.225E-3 1.127E-2 3.062E-2 3.380E-2 1 11
3 806 ATP binding cassette subfamily B genenames.org 4.225E-3 1.127E-2 3.062E-2 3.380E-2 1 11
4 624 Zinc fingers C2H2-type|Kruppel like factors genenames.org 6.906E-3 1.381E-2 3.754E-2
5.525E-2
 1 18
5 775 Myb/SANT domain containing|Trinucleotide repeat containing genenames.org 9.581E-3 1.533E-2 4.166E-2
7.664E-2
 1 25
6 870 Minor histocompatibility antigens|FERM domain containing genenames.org 1.946E-2 2.595E-2
7.052E-2
1.557E-1
 1 51
Show 1 more annotation

13: Coexpression [Display Chart] 9 input genes in category / 769 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18722011-SuppTable2b Human Leukemia Sanchez-Guijo08 22genes GeneSigDB 2.814E-5 2.164E-2
1.563E-1
 2.164E-2 2 21

14: Coexpression Atlas [Display Chart] 9 input genes in category / 588 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 3 input genes in category / 27 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M12947 MORF CTBP1 Neighborhood of CTBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.264E-4 2.231E-2
8.682E-2
 2.231E-2 2 168

16: MicroRNA [Display Chart] 9 input genes in category / 773 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-610:PITA hsa-miR-610:PITA TOP PITA 3.727E-7 2.873E-4 2.077E-3 2.881E-4 3 120
2 ATACCTC,MIR-202:MSigDB ATACCTC,MIR-202:MSigDB MSigDB 1.064E-6 2.873E-4 2.077E-3 8.227E-4 3 170
3 hsa-miR-18b:PITA hsa-miR-18b:PITA TOP PITA 1.487E-6 2.873E-4 2.077E-3 1.149E-3 3 190
4 hsa-miR-18a:PITA hsa-miR-18a:PITA TOP PITA 1.487E-6 2.873E-4 2.077E-3 1.149E-3 3 190
5 hsa-miR-941:PITA hsa-miR-941:PITA TOP PITA 2.109E-6 3.056E-4 2.209E-3 1.630E-3 2 18
6 hsa-miR-202:PITA hsa-miR-202:PITA TOP PITA 2.372E-6 3.056E-4 2.209E-3 1.834E-3 3 222
7 hsa-miR-125b-5p:Functional MTI Functional MTI miRTarbase 1.725E-5 1.702E-3 1.230E-2 1.333E-2 3 431
8 hsa-miR-802:PITA hsa-miR-802:PITA TOP PITA 1.987E-5 1.702E-3 1.230E-2 1.536E-2 3 452
9 hsa-miR-139-3p:mirSVR lowEffct hsa-miR-139-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.261E-5 1.702E-3 1.230E-2 1.748E-2 3 472
10 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 2.421E-5 1.702E-3 1.230E-2 1.872E-2 3 483
11 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 2.421E-5 1.702E-3 1.230E-2 1.872E-2 3 483
12 hsa-miR-4705:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.770E-5 1.785E-3 1.290E-2 2.141E-2 2 64
13 AGGTGCA,MIR-500:MSigDB AGGTGCA,MIR-500:MSigDB MSigDB 5.372E-5 2.831E-3 2.047E-2 4.153E-2 2 89
14 hsa-miR-4464:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.372E-5 2.831E-3 2.047E-2 4.153E-2 2 89
15 hsa-miR-4748:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.494E-5 2.831E-3 2.047E-2 4.247E-2 2 90
16 hsa-miR-329-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.200E-5 2.837E-3 2.051E-2
5.566E-2
 2 103
17 hsa-miR-920:PITA hsa-miR-920:PITA TOP PITA 7.200E-5 2.837E-3 2.051E-2
5.566E-2
 2 103
18 hsa-miR-1286:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.200E-5 2.837E-3 2.051E-2
5.566E-2
 2 103
19 GCACCTT,MIR-18B:MSigDB GCACCTT,MIR-18B:MSigDB MSigDB 7.341E-5 2.837E-3 2.051E-2
5.675E-2
 2 104
20 GCACCTT,MIR-18A:MSigDB GCACCTT,MIR-18A:MSigDB MSigDB 7.341E-5 2.837E-3 2.051E-2
5.675E-2
 2 104
21 hsa-miR-4480:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.061E-4 3.905E-3 2.822E-2
8.200E-2
 2 125
22 hsa-miR-506-3p:Functional MTI Functional MTI miRTarbase 1.130E-4 3.916E-3 2.830E-2
8.733E-2
 2 129
23 hsa-miR-556-5p:PITA hsa-miR-556-5p:PITA TOP PITA 1.165E-4 3.916E-3 2.830E-2
9.006E-2
 2 131
24 hsa-miR-330-3p:Functional MTI Functional MTI miRTarbase 1.447E-4 4.660E-3 3.368E-2
1.118E-1
 2 146
25 hsa-miR-190b:PITA hsa-miR-190b:PITA TOP PITA 1.673E-4 4.736E-3 3.423E-2
1.293E-1
 2 157
26 hsa-miR-190:PITA hsa-miR-190:PITA TOP PITA 1.673E-4 4.736E-3 3.423E-2
1.293E-1
 2 157
27 hsa-miR-152-3p:Functional MTI Functional MTI miRTarbase 1.694E-4 4.736E-3 3.423E-2
1.309E-1
 2 158
28 hsa-miR-628-5p:PITA hsa-miR-628-5p:PITA TOP PITA 1.715E-4 4.736E-3 3.423E-2
1.326E-1
 2 159
29 hsa-miR-1260:PITA hsa-miR-1260:PITA TOP PITA 1.847E-4 4.875E-3 3.524E-2
1.428E-1
 2 165
30 hsa-miR-1274b:PITA hsa-miR-1274b:PITA TOP PITA 1.892E-4 4.875E-3 3.524E-2
1.463E-1
 2 167
31 hsa-miR-519e:PITA hsa-miR-519e:PITA TOP PITA 2.101E-4 5.133E-3 3.710E-2
1.624E-1
 2 176
32 hsa-miR-515-3p:PITA hsa-miR-515-3p:PITA TOP PITA 2.125E-4 5.133E-3 3.710E-2
1.642E-1
 2 177
33 hsa-miR-1278:PITA hsa-miR-1278:PITA TOP PITA 2.296E-4 5.377E-3 3.887E-2
1.775E-1
 2 184
34 AAAGACA,MIR-511:MSigDB AAAGACA,MIR-511:MSigDB MSigDB 2.447E-4 5.564E-3 4.022E-2
1.892E-1
 2 190
35 hsa-miR-4476:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.684E-4 5.680E-3 4.106E-2
2.074E-1
 2 199
36 hsa-miR-6876-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.684E-4 5.680E-3 4.106E-2
2.074E-1
 2 199
37 ATGCTGC,MIR-107:MSigDB ATGCTGC,MIR-107:MSigDB MSigDB 2.792E-4 5.680E-3 4.106E-2
2.158E-1
 2 203
38 ATGCTGC,MIR-103:MSigDB ATGCTGC,MIR-103:MSigDB MSigDB 2.792E-4 5.680E-3 4.106E-2
2.158E-1
 2 203
39 hsa-miR-500b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.875E-4 5.698E-3 4.119E-2
2.222E-1
 2 206
40 hsa-miR-148a-3p:Functional MTI Functional MTI miRTarbase 3.073E-4 5.938E-3 4.292E-2
2.375E-1
 2 213
41 hsa-miR-3663-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.189E-4 6.012E-3 4.346E-2
2.465E-1
 2 217
42 hsa-miR-6734-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.337E-4 6.141E-3 4.439E-2
2.579E-1
 2 222
43 hsa-miR-6131:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.457E-4 6.203E-3 4.484E-2
2.673E-1
 2 226
44 hsa-miR-31:PITA hsa-miR-31:PITA TOP PITA 3.549E-4 6.203E-3 4.484E-2
2.744E-1
 2 229
45 hsa-miR-607:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.611E-4 6.203E-3 4.484E-2
2.791E-1
 2 231
46 hsa-miR-1193:TargetScan hsa-miR-1193 TargetScan 3.705E-4 6.226E-3 4.500E-2
2.864E-1
 2 234
47 hsa-miR-371-5p:PITA hsa-miR-371-5p:PITA TOP PITA 3.994E-4 6.569E-3 4.748E-2
3.087E-1
 2 243
48 hsa-miR-600:PITA hsa-miR-600:PITA TOP PITA 4.192E-4 6.751E-3 4.880E-2
3.241E-1
 2 249
49 hsa-miR-590-5p:PITA hsa-miR-590-5p:PITA TOP PITA 4.603E-4 6.807E-3 4.920E-2
3.558E-1
 2 261
50 hsa-miR-1301:PITA hsa-miR-1301:PITA TOP PITA 4.639E-4 6.807E-3 4.920E-2
3.586E-1
 2 262
Show 45 more annotations

17: Drug [Display Chart] 9 input genes in category / 2964 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000003954 loperamide Stitch 7.772E-6 1.734E-2
1.486E-1
 2.304E-2 3 105
2 CID000104978 fluo-3 Stitch 1.220E-5 1.734E-2
1.486E-1
 3.616E-2 3 122
3 CID000005076 ABT-538 Stitch 2.176E-5 1.734E-2
1.486E-1
6.450E-2
 3 148
4 CID000003540 I-Q-S Stitch 2.547E-5 1.734E-2
1.486E-1
7.550E-2
 3 156
5 CID000448725 1tkx Stitch 3.175E-5 1.734E-2
1.486E-1
9.411E-2
 2 22
6 CID005281751 pseudohypericin Stitch 4.820E-5 1.734E-2
1.486E-1
1.429E-1
 2 27
7 CID000055008 ilmofosine Stitch 4.820E-5 1.734E-2
1.486E-1
1.429E-1
 2 27
8 2367 DN Vincamine [1617-90-9]; Down 200; 11.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 5.032E-5 1.734E-2
1.486E-1
1.491E-1
 3 196
9 1776 DN Eserine sulfate, physostigmine sulfate [64-47-1]; Down 200; 6.2uM; HL60; HG-U133A Broad Institute CMAP Down 5.265E-5 1.734E-2
1.486E-1
1.560E-1
 3 199
10 CID003009355 vicriviroc Stitch 1.236E-4 3.330E-2
2.854E-1
3.663E-1
 2 43
11 CID000124172 SC-9 Stitch 1.236E-4 3.330E-2
2.854E-1
3.663E-1
 2 43
12 CID000001236 niguldipine Stitch 1.354E-4 3.345E-2
2.867E-1
4.014E-1
 2 45
13 CID000035887 N-desmethyl-tamoxifen-hydrochloride Stitch 1.811E-4 3.758E-2
3.222E-1
5.369E-1
 2 52
14 ctd:D007464 Clioquinol CTD 2.578E-4 3.758E-2
3.222E-1
7.641E-1
 2 62
15 CID000001046 pyrazinamide Stitch 3.102E-4 3.758E-2
3.222E-1
9.194E-1
 2 68
16 CID000010206 cepharanthine Stitch 3.287E-4 3.758E-2
3.222E-1
9.743E-1
 2 70
17 CID000469261 AC1LAIW3 Stitch 3.478E-4 3.758E-2
3.222E-1
1.000E0
 2 72
18 ctd:C023378 anhydrocyprinol CTD 3.940E-4 3.758E-2
3.222E-1
1.000E0
 1 1
19 CID000001341 AC1L1B9H Stitch 4.081E-4 3.758E-2
3.222E-1
1.000E0
 2 78
20 CID000003599 miltefosine Stitch 4.081E-4 3.758E-2
3.222E-1
1.000E0
 2 78
21 CID009543473 C-1A Stitch 5.550E-4 3.758E-2
3.222E-1
1.000E0
 2 91
22 CID000165706 lariat Stitch 7.379E-4 3.758E-2
3.222E-1
1.000E0
 2 105
23 CID005281051 hypericin Stitch 7.803E-4 3.758E-2
3.222E-1
1.000E0
 2 108
24 CID000104937 CGP 41251 Stitch 7.803E-4 3.758E-2
3.222E-1
1.000E0
 2 108
25 CID005315980 cnidiadin Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
26 CID000164413 DAPDOX Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
27 CID000443109 NAc-LLY-amide Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
28 CID006449905 62820-12-6 Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
29 CID005321745 taxuspine C Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
30 CID000115215 Ro11-2933 Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
31 CID000197370 Ro44-5912 Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
32 CID000129980 YM212 Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
33 CID005488855 mesochlorin e6 monoethylenediamine Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
34 CID005281903 8-(3,3-dimethylallyl)chrysin Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
35 CID006450549 VX-710-3 Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
36 CID003035447 CGP 20376 Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
37 CID000283230 2,2-diphenyl-1,3-dioxolane Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
38 CID000080969 PPr(i)3 Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
39 ctd:C586265 GSK343 CTD 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
40 CID000155836 sulfurmycin A Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
41 CID000164322 AC1Q6JJG Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
42 CID000383419 AC1L8LCS Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
43 CID001757335 conferone Stitch 7.879E-4 3.758E-2
3.222E-1
1.000E0
 1 2
44 CID000003546 HA1004 Stitch 7.948E-4 3.758E-2
3.222E-1
1.000E0
 2 109
45 CID000002769 cisapride Stitch 8.388E-4 3.758E-2
3.222E-1
1.000E0
 2 112
46 CID011979623 ridostin Stitch 8.993E-4 3.758E-2
3.222E-1
1.000E0
 2 116
47 CID000069602 N-acetylhistamine Stitch 8.993E-4 3.758E-2
3.222E-1
1.000E0
 2 116
48 CID000444766 1c88 Stitch 1.060E-3 3.758E-2
3.222E-1
1.000E0
 2 126
49 CID000164220 NK-250 Stitch 1.182E-3 3.758E-2
3.222E-1
1.000E0
 1 3
50 CID000373763 AC1L87CG Stitch 1.182E-3 3.758E-2
3.222E-1
1.000E0
 1 3
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 204 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0003810 Sertoli-Leydig cell tumor of ovary DisGeNET BeFree 2.740E-6 5.589E-4 3.296E-3 5.589E-4 2 5
2 C1266144 Pleuropulmonary blastoma DisGeNET Curated 2.487E-5 2.536E-3 1.496E-2 5.073E-3 2 14
3 C1839780 FRAGILE X TREMOR/ATAXIA SYNDROME DisGeNET Curated 2.802E-4 8.093E-3 4.773E-2
5.716E-2
 2 46
4 OMIN:601200 PLEUROPULMONARY BLASTOMA; PPB OMIM 5.554E-4 8.093E-3 4.773E-2
1.133E-1
 1 1
5 C4053514 Nasal Chondromesenchymal Hamartoma DisGeNET BeFree 5.554E-4 8.093E-3 4.773E-2
1.133E-1
 1 1
6 C4020704 Sertoli cell neoplasm DisGeNET Curated 5.554E-4 8.093E-3 4.773E-2
1.133E-1
 1 1
7 C1266139 Cystic Partially Differentiated Nephroblastoma DisGeNET BeFree 5.554E-4 8.093E-3 4.773E-2
1.133E-1
 1 1
8 C1567257 Granulosa Cell Cancer DisGeNET Curated 5.554E-4 8.093E-3 4.773E-2
1.133E-1
 1 1
9 cv:C0018022 Goiter, multinodular 1, with or without sertoli-leydig cell tumors Clinical Variations 5.554E-4 8.093E-3 4.773E-2
1.133E-1
 1 1
10 cv:C1867234 Rhabdomyosarcoma, embryonal, 2 Clinical Variations 5.554E-4 8.093E-3 4.773E-2
1.133E-1
 1 1
11 C3839822 DICER1 syndrome DisGeNET BeFree 5.554E-4 8.093E-3 4.773E-2
1.133E-1
 1 1
12 20090226:Sun Prostate cancer GWAS 5.554E-4 8.093E-3 4.773E-2
1.133E-1
 1 1
13 cv:CN072455 DICER1-related pleuropulmonary blastoma cancer predisposition syndrome Clinical Variations 5.554E-4 8.093E-3 4.773E-2
1.133E-1
 1 1
14 C0334401 Malignant Granulosa Cell Tumor DisGeNET Curated 5.554E-4 8.093E-3 4.773E-2
1.133E-1
 1 1
15 C1266047 Fetal adenocarcinoma DisGeNET BeFree 1.110E-3 1.227E-2
7.236E-2
2.265E-1
 1 2
16 C0018413 Gynandroblastoma DisGeNET Curated 1.110E-3 1.227E-2
7.236E-2
2.265E-1
 1 2
17 C1708045 Fetal Lung Adenocarcinoma DisGeNET BeFree 1.110E-3 1.227E-2
7.236E-2
2.265E-1
 1 2
18 C0346251 Sarcoma of kidney DisGeNET Curated 1.110E-3 1.227E-2
7.236E-2
2.265E-1
 1 2
19 C0026985 Myelodysplasia DisGeNET Curated 1.143E-3 1.227E-2
7.236E-2
2.331E-1
 2 93
20 C1883694 Intraocular Medulloepithelioma DisGeNET BeFree 1.665E-3 1.359E-2
8.015E-2
3.397E-1
 1 3
21 C0334596 Medulloepithelioma DisGeNET BeFree 1.665E-3 1.359E-2
8.015E-2
3.397E-1
 1 3
22 C1846034 Euthyroid multinodular goiter DisGeNET Curated 1.665E-3 1.359E-2
8.015E-2
3.397E-1
 1 3
23 C1318541 Sertoli-Leydig cell tumor of intermediate differentiation DisGeNET BeFree 1.665E-3 1.359E-2
8.015E-2
3.397E-1
 1 3
24 C1266138 Benign cystic nephroma DisGeNET BeFree 1.665E-3 1.359E-2
8.015E-2
3.397E-1
 1 3
25 C0006288 Bronchopulmonary Sequestration DisGeNET BeFree 1.665E-3 1.359E-2
8.015E-2
3.397E-1
 1 3
26 C3501844 Familial Nonmedullary Thyroid Cancer DisGeNET BeFree 2.220E-3 1.742E-2
1.027E-1
4.529E-1
 1 4
27 C3838965 Microcystic stromal tumor DisGeNET BeFree 2.774E-3 2.021E-2
1.192E-1
5.659E-1
 1 5
28 C0302859 Euthyroid Goiter DisGeNET Curated 2.774E-3 2.021E-2
1.192E-1
5.659E-1
 1 5
29 C1839463 TARP syndrome DisGeNET Curated 3.328E-3 2.263E-2
1.335E-1
6.790E-1
 1 6
30 C0206723 Sertoli-Leydig Cell Tumor DisGeNET BeFree 3.328E-3 2.263E-2
1.335E-1
6.790E-1
 1 6
31 C1853723 MYOPATHY, DISTAL 2 DisGeNET Curated 3.882E-3 2.555E-2
1.507E-1
7.919E-1
 1 7
32 C2062416 Sindbis virus infection DisGeNET BeFree 4.435E-3 2.742E-2
1.617E-1
9.048E-1
 1 8
33 C1721017 Paraneoplastic Opsoclonus-Myoclonus Ataxia DisGeNET BeFree 4.435E-3 2.742E-2
1.617E-1
9.048E-1
 1 8
34 C1320638 Bone marrow myeloid dysplasia DisGeNET BeFree 4.989E-3 2.975E-2
1.755E-1
1.000E0
 1 9
35 C0205851 Germ cell tumor DisGeNET BeFree 5.255E-3 2.975E-2
1.755E-1
1.000E0
 2 202
36 20090724:Estrada Height GWAS 5.542E-3 2.975E-2
1.755E-1
1.000E0
 1 10
37 C0019269 Hermaphroditism DisGeNET BeFree 5.542E-3 2.975E-2
1.755E-1
1.000E0
 1 10
38 C1861829 Cataract microcornea syndrome DisGeNET Curated 5.542E-3 2.975E-2
1.755E-1
1.000E0
 1 10
39 C3280492 TUMOR PREDISPOSITION SYNDROME DisGeNET Curated 6.094E-3 3.100E-2
1.828E-1
1.000E0
 1 11
40 C1704429 Hypoalphalipoproteinemia, Familial DisGeNET Curated 6.647E-3 3.100E-2
1.828E-1
1.000E0
 1 12
41 C0206724 Sex Cord-Stromal Tumor DisGeNET BeFree 6.647E-3 3.100E-2
1.828E-1
1.000E0
 1 12
42 C0205898 pineoblastoma DisGeNET BeFree 6.647E-3 3.100E-2
1.828E-1
1.000E0
 1 12
43 C0598935 Tumor Initiation DisGeNET BeFree 7.049E-3 3.100E-2
1.828E-1
1.000E0
 2 235
44 C0206752 Alphavirus Infections DisGeNET BeFree 7.199E-3 3.100E-2
1.828E-1
1.000E0
 1 13
45 C1704376 Uterine Corpus Carcinosarcoma DisGeNET BeFree 7.199E-3 3.100E-2
1.828E-1
1.000E0
 1 13
46 C0280630 Uterine Carcinosarcoma DisGeNET BeFree 7.199E-3 3.100E-2
1.828E-1
1.000E0
 1 13
47 C2145472 Urothelial Carcinoma DisGeNET BeFree 7.224E-3 3.100E-2
1.828E-1
1.000E0
 2 238
48 C0021364 Male infertility DisGeNET Curated 7.521E-3 3.100E-2
1.828E-1
1.000E0
 2 243
49 C0005910 Body Weight DisGeNET Curated 7.750E-3 3.100E-2
1.828E-1
1.000E0
 1 14
50 C1849699 Progesterone Resistance DisGeNET BeFree 7.750E-3 3.100E-2
1.828E-1
1.000E0
 1 14
Show 45 more annotations