Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc363_16, positive side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 16 input genes in category / 64 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004683 calmodulin-dependent protein kinase activity 8.596E-17 5.502E-15 2.610E-14 5.502E-15 7 28
2 GO:0005516 calmodulin binding 1.075E-10 3.440E-9 1.632E-8 6.880E-9 7 190
3 GO:0004674 protein serine/threonine kinase activity 4.423E-8 9.436E-7 4.476E-6 2.831E-6 7 452
4 GO:0048306 calcium-dependent protein binding 3.193E-7 5.109E-6 2.424E-5 2.044E-5 4 70
5 GO:0043274 phospholipase binding 7.885E-7 8.411E-6 3.990E-5 5.047E-5 3 22
6 GO:0050998 nitric-oxide synthase binding 7.885E-7 8.411E-6 3.990E-5 5.047E-5 3 22
7 GO:0005088 Ras guanyl-nucleotide exchange factor activity 1.111E-6 1.016E-5 4.820E-5 7.112E-5 5 232
8 GO:0031800 type 3 metabotropic glutamate receptor binding 2.067E-6 1.470E-5 6.972E-5 1.323E-4 2 3
9 GO:0031997 N-terminal myristoylation domain binding 2.067E-6 1.470E-5 6.972E-5 1.323E-4 2 3
10 GO:0005085 guanyl-nucleotide exchange factor activity 4.321E-6 2.766E-5 1.312E-4 2.766E-4 5 306
11 GO:0035254 glutamate receptor binding 7.676E-6 4.466E-5 2.119E-4 4.912E-4 3 46
12 GO:0072542 protein phosphatase activator activity 1.924E-5 1.026E-4 4.868E-4 1.231E-3 2 8
13 GO:0035256 G protein-coupled glutamate receptor binding 2.473E-5 1.217E-4 5.775E-4 1.582E-3 2 9
14 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity 3.089E-5 1.318E-4 6.253E-4 1.977E-3 2 10
15 GO:0030235 nitric-oxide synthase regulator activity 3.089E-5 1.318E-4 6.253E-4 1.977E-3 2 10
16 GO:0019211 phosphatase activator activity 3.774E-5 1.509E-4 7.161E-4 2.415E-3 2 11
17 GO:0008179 adenylate cyclase binding 4.526E-5 1.704E-4 8.084E-4 2.897E-3 2 12
18 GO:0031996 thioesterase binding 6.234E-5 2.100E-4 9.962E-4 3.990E-3 2 14
19 GO:0031432 titin binding 6.234E-5 2.100E-4 9.962E-4 3.990E-3 2 14
20 GO:0051766 inositol trisphosphate kinase activity 1.046E-4 3.348E-4 1.588E-3 6.695E-3 2 18
21 GO:0043539 protein serine/threonine kinase activator activity 1.434E-4 4.369E-4 2.073E-3 9.176E-3 2 21
22 GO:0022834 ligand-gated channel activity 2.538E-4 7.062E-4 3.350E-3 1.624E-2 3 148
23 GO:0015276 ligand-gated ion channel activity 2.538E-4 7.062E-4 3.350E-3 1.624E-2 3 148
24 GO:0043548 phosphatidylinositol 3-kinase binding 4.759E-4 1.269E-3 6.020E-3 3.046E-2 2 38
25 GO:0004686 elongation factor-2 kinase activity 8.574E-4 2.195E-3 1.041E-2
5.487E-2
 1 1
26 GO:0019888 protein phosphatase regulator activity 1.893E-3 4.660E-3 2.210E-2
1.211E-1
 2 76
27 GO:0030295 protein kinase activator activity 1.993E-3 4.723E-3 2.241E-2
1.275E-1
 2 78
28 GO:0019209 kinase activator activity 2.416E-3 5.521E-3 2.619E-2
1.546E-1
 2 86
29 GO:0019208 phosphatase regulator activity 2.527E-3 5.566E-3 2.640E-2
1.618E-1
 2 88
30 GO:0022836 gated channel activity 2.609E-3 5.566E-3 2.640E-2
1.670E-1
 3 331
31 GO:0047485 protein N-terminus binding 4.416E-3 9.117E-3 4.325E-2
2.826E-1
 2 117
32 GO:0044325 ion channel binding 5.181E-3 1.015E-2 4.815E-2
3.316E-1
 2 127
33 GO:0005216 ion channel activity 5.233E-3 1.015E-2 4.815E-2
3.349E-1
 3 424
34 GO:0022838 substrate-specific channel activity 5.728E-3 1.036E-2 4.913E-2
3.666E-1
 3 438
35 GO:0035381 ATP-gated ion channel activity 5.987E-3 1.036E-2 4.913E-2
3.832E-1
 1 7
36 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 5.987E-3 1.036E-2 4.913E-2
3.832E-1
 1 7
37 GO:0004931 extracellularly ATP-gated cation channel activity 5.987E-3 1.036E-2 4.913E-2
3.832E-1
 1 7
38 GO:0015267 channel activity 6.963E-3 1.149E-2
5.452E-2
4.456E-1
 3 470
39 GO:0022803 passive transmembrane transporter activity 7.004E-3 1.149E-2
5.452E-2
4.482E-1
 3 471
40 GO:0019887 protein kinase regulator activity 1.184E-2 1.894E-2
8.986E-2
7.577E-1
 2 195
41 GO:0019207 kinase regulator activity 1.438E-2 2.245E-2
1.065E-1
9.205E-1
 2 216
42 GO:0032794 GTPase activating protein binding 1.533E-2 2.281E-2
1.082E-1
9.810E-1
 1 18
43 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1.533E-2 2.281E-2
1.082E-1
9.810E-1
 1 18
44 GO:0010857 calcium-dependent protein kinase activity 1.617E-2 2.352E-2
1.116E-1
1.000E0
 1 19
45 GO:0001614 purinergic nucleotide receptor activity 1.870E-2 2.602E-2
1.235E-1
1.000E0
 1 22
46 GO:0016502 nucleotide receptor activity 1.870E-2 2.602E-2
1.235E-1
1.000E0
 1 22
47 GO:0001530 lipopolysaccharide binding 1.955E-2 2.662E-2
1.263E-1
1.000E0
 1 23
48 GO:0001664 G protein-coupled receptor binding 2.282E-2 2.992E-2
1.419E-1
1.000E0
 2 276
49 GO:0035586 purinergic receptor activity 2.291E-2 2.992E-2
1.419E-1
1.000E0
 1 27
Show 44 more annotations

2: GO: Biological Process [Display Chart] 16 input genes in category / 842 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0046777 protein autophosphorylation 9.408E-12 7.921E-9 5.793E-8 7.921E-9 8 245
2 GO:0051924 regulation of calcium ion transport 6.115E-10 2.574E-7 1.883E-6 5.148E-7 7 243
3 GO:0010959 regulation of metal ion transport 1.220E-8 3.423E-6 2.503E-5 1.027E-5 7 374
4 GO:0006816 calcium ion transport 2.110E-8 4.443E-6 3.249E-5 1.777E-5 7 405
5 GO:0070838 divalent metal ion transport 4.693E-8 6.889E-6 5.038E-5 3.951E-5 7 455
6 GO:0072511 divalent inorganic cation transport 4.909E-8 6.889E-6 5.038E-5 4.133E-5 7 458
7 GO:1901841 regulation of high voltage-gated calcium channel activity 6.221E-8 7.483E-6 5.473E-5 5.238E-5 3 10
8 GO:0099643 signal release from synapse 1.952E-7 1.826E-5 1.335E-4 1.643E-4 5 163
9 GO:0007269 neurotransmitter secretion 1.952E-7 1.826E-5 1.335E-4 1.643E-4 5 163
10 GO:0099531 presynaptic process involved in chemical synaptic transmission 2.625E-7 2.210E-5 1.617E-4 2.210E-4 5 173
11 GO:0006836 neurotransmitter transport 7.193E-7 5.079E-5 3.715E-4 6.056E-4 5 212
12 GO:0001505 regulation of neurotransmitter levels 7.534E-7 5.079E-5 3.715E-4 6.344E-4 5 214
13 GO:0051000 positive regulation of nitric-oxide synthase activity 7.933E-7 5.079E-5 3.715E-4 6.680E-4 3 22
14 GO:0090257 regulation of muscle system process 8.445E-7 5.079E-5 3.715E-4 7.111E-4 5 219
15 GO:1901385 regulation of voltage-gated calcium channel activity 1.503E-6 8.436E-5 6.170E-4 1.265E-3 3 27
16 GO:0032770 positive regulation of monooxygenase activity 1.875E-6 9.870E-5 7.218E-4 1.579E-3 3 29
17 GO:0023061 signal release 2.262E-6 1.120E-4 8.194E-4 1.905E-3 6 498
18 GO:0051928 positive regulation of calcium ion transport 3.002E-6 1.343E-4 9.823E-4 2.528E-3 4 122
19 GO:0043270 positive regulation of ion transport 3.031E-6 1.343E-4 9.823E-4 2.552E-3 5 284
20 GO:0051592 response to calcium ion 3.414E-6 1.437E-4 1.051E-3 2.875E-3 4 126
21 GO:1903651 positive regulation of cytoplasmic transport 3.835E-6 1.538E-4 1.125E-3 3.229E-3 5 298
22 GO:0007223 Wnt signaling pathway, calcium modulating pathway 4.666E-6 1.786E-4 1.306E-3 3.929E-3 3 39
23 GO:0060999 positive regulation of dendritic spine development 6.288E-6 2.206E-4 1.613E-3 5.294E-3 3 43
24 GO:0031952 regulation of protein autophosphorylation 6.288E-6 2.206E-4 1.613E-3 5.294E-3 3 43
25 GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity 6.910E-6 2.252E-4 1.647E-3 5.818E-3 2 5
26 GO:0034767 positive regulation of ion transmembrane transport 7.193E-6 2.252E-4 1.647E-3 6.056E-3 4 152
27 GO:2001259 positive regulation of cation channel activity 7.222E-6 2.252E-4 1.647E-3 6.081E-3 3 45
28 GO:0034764 positive regulation of transmembrane transport 8.812E-6 2.650E-4 1.938E-3 7.420E-3 4 160
29 GO:0051353 positive regulation of oxidoreductase activity 9.950E-6 2.758E-4 2.017E-3 8.378E-3 3 50
30 GO:0050999 regulation of nitric-oxide synthase activity 9.950E-6 2.758E-4 2.017E-3 8.378E-3 3 50
31 GO:0010038 response to metal ion 1.015E-5 2.758E-4 2.017E-3 8.548E-3 5 364
32 GO:0032388 positive regulation of intracellular transport 1.526E-5 4.016E-4 2.937E-3 1.285E-2 5 396
33 GO:0010524 positive regulation of calcium ion transport into cytosol 1.643E-5 4.191E-4 3.065E-3 1.383E-2 3 59
34 GO:0032768 regulation of monooxygenase activity 1.817E-5 4.499E-4 3.290E-3 1.530E-2 3 61
35 GO:0060998 regulation of dendritic spine development 2.200E-5 5.293E-4 3.871E-3 1.852E-2 3 65
36 GO:0003012 muscle system process 2.270E-5 5.308E-4 3.882E-3 1.911E-2 5 430
37 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 2.483E-5 5.360E-4 3.920E-3 2.090E-2 2 9
38 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity 2.483E-5 5.360E-4 3.920E-3 2.090E-2 2 9
39 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity 2.483E-5 5.360E-4 3.920E-3 2.090E-2 2 9
40 GO:0055117 regulation of cardiac muscle contraction 2.750E-5 5.789E-4 4.234E-3 2.315E-2 3 70
41 GO:0051823 regulation of synapse structural plasticity 3.102E-5 6.370E-4 4.659E-3 2.612E-2 2 10
42 GO:1901019 regulation of calcium ion transmembrane transporter activity 3.250E-5 6.515E-4 4.765E-3 2.736E-2 3 74
43 GO:1900034 regulation of cellular response to heat 3.521E-5 6.894E-4 5.042E-3 2.964E-2 3 76
44 GO:0032414 positive regulation of ion transmembrane transporter activity 3.954E-5 7.566E-4 5.534E-3 3.329E-2 3 79
45 GO:0016358 dendrite development 4.265E-5 7.972E-4 5.830E-3 3.591E-2 4 239
46 GO:0044275 cellular carbohydrate catabolic process 4.421E-5 7.972E-4 5.830E-3 3.722E-2 3 82
47 GO:0045860 positive regulation of protein kinase activity 4.498E-5 7.972E-4 5.830E-3 3.788E-2 5 496
48 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 4.545E-5 7.972E-4 5.830E-3 3.827E-2 2 12
49 GO:1900006 positive regulation of dendrite development 4.752E-5 8.128E-4 5.944E-3 4.001E-2 3 84
50 GO:0060333 interferon-gamma-mediated signaling pathway 4.923E-5 8.128E-4 5.944E-3 4.145E-2 3 85
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 16 input genes in category / 82 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0014069 postsynaptic density 5.332E-14 2.186E-12 1.091E-11 4.372E-12 9 232
2 GO:0099572 postsynaptic specialization 5.332E-14 2.186E-12 1.091E-11 4.372E-12 9 232
3 GO:0060076 excitatory synapse 1.129E-13 3.086E-12 1.540E-11 9.258E-12 9 252
4 GO:0098794 postsynapse 2.038E-11 4.179E-10 2.085E-9 1.671E-9 9 449
5 GO:0033017 sarcoplasmic reticulum membrane 4.354E-6 7.140E-5 3.563E-4 3.570E-4 3 39
6 GO:0098793 presynapse 6.610E-6 9.033E-5 4.508E-4 5.420E-4 5 341
7 GO:0030672 synaptic vesicle membrane 1.695E-5 1.703E-4 8.496E-4 1.390E-3 3 61
8 GO:0099501 exocytic vesicle membrane 1.695E-5 1.703E-4 8.496E-4 1.390E-3 3 61
9 GO:0034704 calcium channel complex 1.869E-5 1.703E-4 8.496E-4 1.532E-3 3 63
10 GO:0016529 sarcoplasmic reticulum 2.150E-5 1.763E-4 8.798E-4 1.763E-3 3 66
11 GO:0016528 sarcoplasm 3.033E-5 2.261E-4 1.128E-3 2.487E-3 3 74
12 GO:0008076 voltage-gated potassium channel complex 5.822E-5 3.793E-4 1.893E-3 4.774E-3 3 92
13 GO:0034705 potassium channel complex 6.013E-5 3.793E-4 1.893E-3 4.931E-3 3 93
14 GO:0008021 synaptic vesicle 2.785E-4 1.482E-3 7.393E-3 2.283E-2 3 156
15 GO:0030666 endocytic vesicle membrane 2.785E-4 1.482E-3 7.393E-3 2.283E-2 3 156
16 GO:0030658 transport vesicle membrane 2.891E-4 1.482E-3 7.393E-3 2.371E-2 3 158
17 GO:0070382 exocytic vesicle 3.709E-4 1.789E-3 8.926E-3 3.041E-2 3 172
18 GO:0034703 cation channel complex 3.967E-4 1.807E-3 9.018E-3 3.253E-2 3 176
19 GO:0030017 sarcomere 5.596E-4 2.415E-3 1.205E-2 4.588E-2 3 198
20 GO:0044449 contractile fiber part 7.110E-4 2.915E-3 1.455E-2
5.831E-2
 3 215
21 GO:0030016 myofibril 7.601E-4 2.968E-3 1.481E-2
6.233E-2
 3 220
22 GO:0043292 contractile fiber 9.089E-4 3.388E-3 1.690E-2
7.453E-2
 3 234
23 GO:0005876 spindle microtubule 1.137E-3 4.052E-3 2.022E-2
9.320E-2
 2 60
24 GO:0030139 endocytic vesicle 1.301E-3 4.446E-3 2.218E-2
1.067E-1
 3 265
25 GO:1902937 inward rectifier potassium channel complex 1.678E-3 5.368E-3 2.678E-2
1.376E-1
 1 2
26 GO:0034702 ion channel complex 1.702E-3 5.368E-3 2.678E-2
1.396E-1
 3 291
27 GO:0097060 synaptic membrane 1.822E-3 5.532E-3 2.761E-2
1.494E-1
 3 298
28 GO:0005819 spindle 2.002E-3 5.862E-3 2.925E-2
1.641E-1
 3 308
29 GO:1902495 transmembrane transporter complex 2.373E-3 6.711E-3 3.349E-2
1.946E-1
 3 327
30 GO:1990351 transporter complex 2.499E-3 6.831E-3 3.409E-2
2.049E-1
 3 333
31 GO:0030133 transport vesicle 3.470E-3 9.180E-3 4.581E-2
2.846E-1
 3 374
32 GO:0043195 terminal bouton 3.891E-3 9.971E-3 4.976E-2
3.191E-1
 2 112
33 GO:1990454 L-type voltage-gated calcium channel complex 5.027E-3 1.249E-2
6.233E-2
4.122E-1
 1 6
34 GO:0000922 spindle pole 5.439E-3 1.312E-2
6.546E-2
4.460E-1
 2 133
35 GO:0032059 bleb 6.697E-3 1.569E-2
7.829E-2
5.491E-1
 1 8
36 GO:0030426 growth cone 9.964E-3 2.265E-2
1.130E-1
8.171E-1
 2 182
37 GO:0043679 axon terminus 1.039E-2 2.265E-2
1.130E-1
8.518E-1
 2 186
38 GO:0030427 site of polarized growth 1.050E-2 2.265E-2
1.130E-1
8.606E-1
 2 187
39 GO:0031229 intrinsic component of nuclear inner membrane 1.169E-2 2.364E-2
1.180E-1
9.587E-1
 1 14
40 GO:0005639 integral component of nuclear inner membrane 1.169E-2 2.364E-2
1.180E-1
9.587E-1
 1 14
41 GO:0044306 neuron projection terminus 1.182E-2 2.364E-2
1.180E-1
9.692E-1
 2 199
42 GO:0043209 myelin sheath 1.216E-2 2.375E-2
1.185E-1
9.973E-1
 2 202
43 GO:0044453 nuclear membrane part 1.252E-2 2.388E-2
1.192E-1
1.000E0
 1 15
44 GO:0045211 postsynaptic membrane 1.493E-2 2.782E-2
1.388E-1
1.000E0
 2 225
45 GO:0032839 dendrite cytoplasm 1.749E-2 3.187E-2
1.590E-1
1.000E0
 1 21
46 GO:0031965 nuclear membrane 2.405E-2 4.287E-2
2.139E-1
1.000E0
 2 290
47 GO:0051233 spindle midzone 2.490E-2 4.344E-2
2.168E-1
1.000E0
 1 30
48 GO:0033267 axon part 2.706E-2 4.623E-2
2.307E-1
1.000E0
 2 309
49 GO:0099568 cytoplasmic region 2.971E-2 4.972E-2
2.481E-1
1.000E0
 2 325
Show 44 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 61 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001664 Torsade de pointes 2.068E-4 1.261E-2
5.924E-2
 1.261E-2 2 22
2 HP:0001663 Ventricular fibrillation 9.987E-4 2.104E-2
9.882E-2
6.092E-2
 2 48
3 HP:0001657 Prolonged QT interval 1.359E-3 2.104E-2
9.882E-2
8.289E-2
 2 56
4 HP:0031547 Abnormal QT interval 1.457E-3 2.104E-2
9.882E-2
8.889E-2
 2 58
5 HP:0003115 Abnormal EKG 2.493E-3 2.104E-2
9.882E-2
1.521E-1
 2 76
6 HP:0500014 Abnormal test result 2.760E-3 2.104E-2
9.882E-2
1.683E-1
 2 80
7 HP:0003114 Abnormal cardiological findings 2.760E-3 2.104E-2
9.882E-2
1.683E-1
 2 80
8 HP:0500015 Abnormal cardiac test 2.760E-3 2.104E-2
9.882E-2
1.683E-1
 2 80
9 HP:0001279 Syncope 3.955E-3 2.681E-2
1.259E-1
2.413E-1
 2 96
10 HP:0001645 Sudden cardiac death 4.986E-3 3.041E-2
1.428E-1
3.041E-1
 2 108
11 HP:0001695 Cardiac arrest 6.848E-3 3.480E-2
1.634E-1
4.177E-1
 2 127
12 HP:0004308 Ventricular arrhythmia 7.275E-3 3.480E-2
1.634E-1
4.438E-1
 2 131
13 HP:0025478 Atrial standstill 7.417E-3 3.480E-2
1.634E-1
4.524E-1
 1 7
Show 8 more annotations

5: Mouse Phenotype [Display Chart] 12 input genes in category / 301 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002915 abnormal synaptic depression 3.323E-9 1.000E-6 6.286E-6 1.000E-6 6 132
2 MP:0002802 abnormal discrimination learning 2.418E-8 3.639E-6 2.287E-5 7.278E-6 4 29
3 MP:0012315 impaired learning 3.951E-8 3.874E-6 2.435E-5 1.189E-5 5 93
4 MP:0002061 abnormal aggression-related behavior 5.148E-8 3.874E-6 2.435E-5 1.550E-5 5 98
5 MP:0002969 impaired social transmission of food preference 1.952E-7 9.792E-6 6.155E-5 5.875E-5 3 11
6 MP:0012296 impaired discrimination learning 1.952E-7 9.792E-6 6.155E-5 5.875E-5 3 11
7 MP:0002916 increased synaptic depression 1.140E-6 4.904E-5 3.082E-4 3.432E-4 3 19
8 MP:0002557 abnormal social/conspecific interaction 1.588E-6 5.976E-5 3.757E-4 4.781E-4 6 372
9 MP:0002924 delayed CNS synapse formation 3.691E-6 1.234E-4 7.760E-4 1.111E-3 2 3
10 MP:0001360 abnormal social investigation 1.086E-5 3.269E-4 2.055E-3 3.269E-3 4 130
11 MP:0001353 increased aggression towards mice 1.237E-5 3.384E-4 2.127E-3 3.722E-3 3 41
12 MP:0009358 environmentally induced seizures 1.997E-5 5.010E-4 3.149E-3 6.012E-3 3 48
13 MP:0005655 increased aggression 2.853E-5 6.606E-4 4.152E-3 8.588E-3 3 54
14 MP:0002064 seizures 4.700E-5 1.010E-3 6.351E-3 1.415E-2 5 390
15 MP:0009357 abnormal seizure response to inducing agent 5.363E-5 1.050E-3 6.600E-3 1.614E-2 4 195
16 MP:0001468 abnormal temporal memory 5.581E-5 1.050E-3 6.600E-3 1.680E-2 4 197
17 MP:0004994 abnormal brain wave pattern 7.971E-5 1.386E-3 8.713E-3 2.399E-2 3 76
18 MP:0003997 tonic-clonic seizures 8.288E-5 1.386E-3 8.713E-3 2.495E-2 3 77
19 MP:0009454 impaired contextual conditioning behavior 9.291E-5 1.435E-3 9.021E-3 2.797E-2 3 80
20 MP:0002922 decreased post-tetanic potentiation 9.535E-5 1.435E-3 9.021E-3 2.870E-2 2 13
21 MP:0001458 abnormal object recognition memory 1.153E-4 1.652E-3 1.039E-2 3.470E-2 3 86
22 MP:0002945 abnormal inhibitory postsynaptic currents 1.234E-4 1.689E-3 1.062E-2 3.716E-2 3 88
23 MP:0001898 abnormal long term depression 1.599E-4 2.093E-3 1.315E-2 4.813E-2 3 96
24 MP:0002912 abnormal excitatory postsynaptic potential 2.267E-4 2.843E-3 1.787E-2
6.823E-2
 3 108
25 MP:0011956 abnormal compensatory feeding amount 2.554E-4 2.957E-3 1.859E-2
7.688E-2
 2 21
26 MP:0002921 abnormal post-tetanic potentiation 2.554E-4 2.957E-3 1.859E-2
7.688E-2
 2 21
27 MP:0012317 impaired conditioning behavior 4.095E-4 4.565E-3 2.870E-2
1.233E-1
 3 132
28 MP:0002910 abnormal excitatory postsynaptic currents 5.503E-4 5.915E-3 3.718E-2
1.656E-1
 3 146
29 MP:0003863 decreased aggression towards mice 6.372E-4 6.614E-3 4.157E-2
1.918E-1
 2 33
30 MP:0001364 decreased anxiety-related response 7.321E-4 7.345E-3 4.617E-2
2.204E-1
 3 161
31 MP:0001469 abnormal contextual conditioning behavior 8.003E-4 7.770E-3 4.884E-2
2.409E-1
 3 166
32 MP:0004996 abnormal CNS synapse formation 8.457E-4 7.955E-3
5.000E-2
2.545E-1
 2 38
33 MP:0000947 convulsive seizures 9.643E-4 8.795E-3
5.529E-2
2.902E-1
 3 177
34 MP:0001475 reduced long term depression 1.134E-3 9.966E-3
6.265E-2
3.412E-1
 2 44
35 MP:0011622 abnormal habituation to a novel odor 1.159E-3 9.966E-3
6.265E-2
3.488E-1
 1 1
36 MP:0005656 decreased aggression 1.348E-3 1.127E-2
7.086E-2
4.058E-1
 2 48
37 MP:0004792 abnormal synaptic vesicle number 1.642E-3 1.300E-2
8.174E-2
4.942E-1
 2 53
38 MP:0001441 increased grooming behavior 1.642E-3 1.300E-2
8.174E-2
4.942E-1
 2 53
39 MP:0008143 abnormal dendrite morphology 1.951E-3 1.506E-2
9.465E-2
5.872E-1
 3 226
40 MP:0004769 abnormal synaptic vesicle morphology 2.099E-3 1.580E-2
9.930E-2
6.319E-1
 2 60
41 MP:0002207 abnormal long term potentiation 2.262E-3 1.660E-2
1.044E-1
6.809E-1
 3 238
42 MP:0011120 increased primordial ovarian follicle number 2.316E-3 1.660E-2
1.044E-1
6.973E-1
 1 2
43 MP:0005458 increased percent body fat/body weight 2.459E-3 1.721E-2
1.082E-1
7.402E-1
 2 65
44 MP:0004859 abnormal synaptic plasticity 2.846E-3 1.947E-2
1.224E-1
8.566E-1
 2 70
45 MP:0002918 abnormal paired-pulse facilitation 3.175E-3 2.124E-2
1.335E-1
9.556E-1
 2 74
46 MP:0011124 increased primary ovarian follicle number 3.473E-3 2.272E-2
1.428E-1
1.000E0
 1 3
47 MP:0001928 abnormal ovulation 3.977E-3 2.547E-2
1.601E-1
1.000E0
 2 83
48 MP:0012006 abnormal hippocampus physiology 4.628E-3 2.902E-2
1.824E-1
1.000E0
 1 4
49 MP:0002062 abnormal associative learning 5.181E-3 3.183E-2
2.001E-1
1.000E0
 3 319
50 MP:0011958 increased compensatory feeding amount 5.782E-3 3.481E-2
2.188E-1
1.000E0
 1 5
Show 45 more annotations

6: Domain [Display Chart] 15 input genes in category / 94 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR020636 Ca/CaM-dep Ca-dep prot Kinase InterPro 9.741E-12 9.157E-10 4.694E-9 9.157E-10 6 69
2 IPR019735 Synapsin CS InterPro 4.152E-10 3.548E-9 1.819E-8 3.903E-8 3 3
3 IPR001359 Synapsin InterPro 4.152E-10 3.548E-9 1.819E-8 3.903E-8 3 3
4 IPR020897 Synapsin pre-ATP-grasp dom InterPro 4.152E-10 3.548E-9 1.819E-8 3.903E-8 3 3
5 PS00415 SYNAPSIN 1 PROSITE 4.152E-10 3.548E-9 1.819E-8 3.903E-8 3 3
6 PF10581 Synapsin N Pfam 4.152E-10 3.548E-9 1.819E-8 3.903E-8 3 3
7 PF02078 Synapsin Pfam 4.152E-10 3.548E-9 1.819E-8 3.903E-8 3 3
8 PF02750 Synapsin C Pfam 4.152E-10 3.548E-9 1.819E-8 3.903E-8 3 3
9 IPR019736 Synapsin P site InterPro 4.152E-10 3.548E-9 1.819E-8 3.903E-8 3 3
10 IPR020898 Synapsin ATP-bd dom InterPro 4.152E-10 3.548E-9 1.819E-8 3.903E-8 3 3
11 PS00416 SYNAPSIN 2 PROSITE 4.152E-10 3.548E-9 1.819E-8 3.903E-8 3 3
12 PF08332 CaMKII AD Pfam 1.660E-9 1.200E-8 6.153E-8 1.560E-7 3 4
13 IPR013543 Ca/CaM-dep prot kinase-assoc InterPro 1.660E-9 1.200E-8 6.153E-8 1.560E-7 3 4
14 3.40.50.20 - Gene3D 1.182E-7 7.406E-7 3.796E-6 1.111E-5 3 13
15 3.10.450.50 - Gene3D 1.182E-7 7.406E-7 3.796E-6 1.111E-5 3 13
16 IPR016185 PreATP-grasp dom InterPro 1.503E-7 8.833E-7 4.527E-6 1.413E-5 3 14
17 3.30.1490.20 - Gene3D 1.878E-7 9.653E-7 4.948E-6 1.766E-5 3 15
18 IPR032710 NTF2-like dom InterPro 1.878E-7 9.653E-7 4.948E-6 1.766E-5 3 15
19 IPR008271 Ser/Thr kinase AS InterPro 1.987E-7 9.653E-7 4.948E-6 1.868E-5 6 357
20 SM00220 S TKc SMART 2.054E-7 9.653E-7 4.948E-6 1.931E-5 6 359
21 PS00108 PROTEIN KINASE ST PROSITE 2.157E-7 9.655E-7 4.949E-6 2.028E-5 6 362
22 IPR017441 Protein kinase ATP BS InterPro 2.826E-7 1.191E-6 6.106E-6 2.656E-5 6 379
23 PF00069 Pkinase Pfam 2.915E-7 1.191E-6 6.106E-6 2.740E-5 6 381
24 IPR013815 ATP grasp subdomain 1 InterPro 3.364E-7 1.265E-6 6.483E-6 3.162E-5 3 18
25 3.30.470.20 - Gene3D 3.364E-7 1.265E-6 6.483E-6 3.162E-5 3 18
26 PS00107 PROTEIN KINASE ATP PROSITE 8.684E-7 3.139E-6 1.609E-5 8.163E-5 6 459
27 IPR000719 Prot kinase dom InterPro 1.256E-6 4.374E-6 2.242E-5 1.181E-4 6 489
28 PS50011 PROTEIN KINASE DOM PROSITE 1.317E-6 4.423E-6 2.267E-5 1.238E-4 6 493
29 IPR013816 ATP grasp subdomain 2 InterPro 1.841E-6 5.969E-6 3.059E-5 1.731E-4 3 31
30 IPR028713 SYN1 InterPro 8.006E-4 2.428E-3 1.244E-2
7.526E-2
 1 1
31 IPR003050 P2X7 purnocptor InterPro 8.006E-4 2.428E-3 1.244E-2
7.526E-2
 1 1
32 IPR017400 eEF-2K InterPro 1.601E-3 4.425E-3 2.268E-2
1.505E-1
 1 2
33 IPR010599 CNKSR2 InterPro 1.601E-3 4.425E-3 2.268E-2
1.505E-1
 1 2
34 PF06663 DUF1170 Pfam 1.601E-3 4.425E-3 2.268E-2
1.505E-1
 1 2
35 PS51290 CRIC PROSITE 2.400E-3 6.098E-3 3.126E-2
2.256E-1
 1 3
36 PF10534 CRIC ras sig Pfam 2.400E-3 6.098E-3 3.126E-2
2.256E-1
 1 3
37 IPR017874 CRIC domain InterPro 2.400E-3 6.098E-3 3.126E-2
2.256E-1
 1 3
38 IPR004166 MHCK EF2 kinase InterPro 5.592E-3 1.143E-2
5.857E-2
5.256E-1
 1 7
39 IPR001429 P2X purnocptor InterPro 5.592E-3 1.143E-2
5.857E-2
5.256E-1
 1 7
40 2.60.490.10 - Gene3D 5.592E-3 1.143E-2
5.857E-2
5.256E-1
 1 7
41 PF02816 Alpha kinase Pfam 5.592E-3 1.143E-2
5.857E-2
5.256E-1
 1 7
42 IPR027309 P2X extracellular dom InterPro 5.592E-3 1.143E-2
5.857E-2
5.256E-1
 1 7
43 PS51158 ALPHA KINASE PROSITE 5.592E-3 1.143E-2
5.857E-2
5.256E-1
 1 7
44 PS01212 P2X RECEPTOR PROSITE 5.592E-3 1.143E-2
5.857E-2
5.256E-1
 1 7
45 SM00811 Alpha kinase SMART 5.592E-3 1.143E-2
5.857E-2
5.256E-1
 1 7
46 PF00864 P2X receptor Pfam 5.592E-3 1.143E-2
5.857E-2
5.256E-1
 1 7
47 PF08238 Sel1 Pfam 7.184E-3 1.437E-2
7.365E-2
6.753E-1
 1 9
48 IPR006597 Sel1-like InterPro 7.980E-3 1.563E-2
8.010E-2
7.501E-1
 1 10
49 PF00640 PID Pfam 2.219E-2 4.257E-2
2.182E-1
1.000E0
 1 28
50 PS01179 PID PROSITE 2.533E-2 4.761E-2
2.441E-1
1.000E0
 1 32
Show 45 more annotations

7: Pathway [Display Chart] 16 input genes in category / 287 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3412 Ca++/ Calmodulin-dependent Protein Kinase Activation MSigDB C2 BIOCARTA (v6.0) 2.696E-21 7.739E-19 4.828E-18 7.739E-19 8 14
2 M15181 Regulation of PGC-1a MSigDB C2 BIOCARTA (v6.0) 4.265E-16 6.120E-14 3.818E-13 1.224E-13 7 24
3 952859 Oxytocin signaling pathway BioSystems: KEGG 5.363E-14 5.131E-12 3.201E-11 1.539E-11 9 153
4 1268766 Transmission across Chemical Synapses BioSystems: REACTOME 1.350E-12 9.685E-11 6.042E-10 3.874E-10 9 218
5 1268800 Post NMDA receptor activation events BioSystems: REACTOME 3.527E-12 2.025E-10 1.263E-9 1.012E-9 6 37
6 1272485 Aldosterone synthesis and secretion BioSystems: KEGG 4.516E-12 2.160E-10 1.347E-9 1.296E-9 7 82
7 1268798 Activation of NMDA receptor upon glutamate binding and postsynaptic events BioSystems: REACTOME 6.804E-12 2.790E-10 1.740E-9 1.953E-9 6 41
8 1268805 CREB phosphorylation through the activation of CaMKII BioSystems: REACTOME 1.076E-11 3.859E-10 2.407E-9 3.087E-9 5 17
9 1268802 Ras activation uopn Ca2+ infux through NMDA receptor BioSystems: REACTOME 2.018E-11 6.436E-10 4.015E-9 5.793E-9 5 19
10 1268763 Neuronal System BioSystems: REACTOME 9.770E-11 2.804E-9 1.749E-8 2.804E-8 9 351
11 83085 Long-term potentiation BioSystems: KEGG 1.483E-10 3.870E-9 2.414E-8 4.257E-8 6 67
12 547607 Amphetamine addiction BioSystems: KEGG 1.626E-10 3.888E-9 2.425E-8 4.665E-8 6 68
13 1268801 CREB phosphorylation through the activation of Ras BioSystems: REACTOME 2.046E-10 4.517E-9 2.818E-8 5.872E-8 5 29
14 138040 IFN-gamma pathway BioSystems: Pathway Interaction Database 1.125E-9 2.305E-8 1.438E-7 3.228E-7 5 40
15 83050 Calcium signaling pathway BioSystems: KEGG 1.301E-9 2.422E-8 1.511E-7 3.735E-7 7 182
16 698773 Circadian entrainment BioSystems: KEGG 1.350E-9 2.422E-8 1.511E-7 3.876E-7 6 96
17 M13494 Bioactive Peptide Induced Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.641E-9 2.771E-8 1.729E-7 4.711E-7 5 43
18 1339117 Phase 0 - rapid depolarisation BioSystems: REACTOME 2.608E-9 4.158E-8 2.594E-7 7.485E-7 5 47
19 101143 Neurotrophin signaling pathway BioSystems: KEGG 4.975E-9 7.515E-8 4.688E-7 1.428E-6 6 119
20 1339121 Ion homeostasis BioSystems: REACTOME 6.452E-9 9.091E-8 5.672E-7 1.852E-6 5 56
21 1268807 Activation of CaMK IV BioSystems: REACTOME 6.961E-9 9.091E-8 5.672E-7 1.998E-6 3 4
22 M16966 Stathmin and breast cancer resistance to antimicrotubule agents MSigDB C2 BIOCARTA (v6.0) 6.969E-9 9.091E-8 5.672E-7 2.000E-6 4 19
23 1269951 Ion transport by P-type ATPases BioSystems: REACTOME 7.728E-9 9.643E-8 6.016E-7 2.218E-6 5 58
24 83110 Glioma BioSystems: KEGG 1.280E-8 1.531E-7 9.550E-7 3.674E-6 5 64
25 1269296 CaMK IV-mediated phosphorylation of CREB BioSystems: REACTOME 1.739E-8 1.962E-7 1.224E-6 4.990E-6 3 5
26 1268786 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell BioSystems: REACTOME 1.777E-8 1.962E-7 1.224E-6 5.100E-6 6 147
27 154409 Gastric acid secretion BioSystems: KEGG 2.874E-8 3.055E-7 1.906E-6 8.250E-6 5 75
28 1268806 CREB phosphorylation through the activation of CaMKK BioSystems: REACTOME 3.475E-8 3.562E-7 2.222E-6 9.973E-6 3 6
29 1269431 IRS-mediated signalling BioSystems: REACTOME 3.990E-8 3.890E-7 2.427E-6 1.145E-5 7 298
30 1269429 Insulin receptor signalling cascade BioSystems: REACTOME 4.274E-8 3.890E-7 2.427E-6 1.227E-5 7 301
31 1269620 IRS-related events triggered by IGF1R BioSystems: REACTOME 4.373E-8 3.890E-7 2.427E-6 1.255E-5 7 302
32 1269618 IGF1R signaling cascade BioSystems: REACTOME 4.373E-8 3.890E-7 2.427E-6 1.255E-5 7 302
33 1269617 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) BioSystems: REACTOME 4.473E-8 3.890E-7 2.427E-6 1.284E-5 7 303
34 1269428 Signaling by Insulin receptor BioSystems: REACTOME 7.392E-8 6.240E-7 3.893E-6 2.121E-5 7 326
35 83091 GnRH signaling pathway BioSystems: KEGG 8.088E-8 6.632E-7 4.137E-6 2.321E-5 5 92
36 1017634 cAMP signaling pathway BioSystems: KEGG 1.052E-7 8.191E-7 5.110E-6 3.019E-5 6 198
37 948277 Inflammatory mediator regulation of TRP channels BioSystems: KEGG 1.056E-7 8.191E-7 5.110E-6 3.031E-5 5 97
38 83092 Melanogenesis BioSystems: KEGG 1.294E-7 9.746E-7 6.080E-6 3.714E-5 5 101
39 1269479 Downstream signal transduction BioSystems: REACTOME 1.324E-7 9.746E-7 6.080E-6 3.801E-5 7 355
40 1144996 Glucagon signaling pathway BioSystems: KEGG 1.428E-7 1.001E-6 6.243E-6 4.099E-5 5 103
41 1269284 DAP12 signaling BioSystems: REACTOME 1.430E-7 1.001E-6 6.243E-6 4.103E-5 7 359
42 1269380 Signaling by EGFR BioSystems: REACTOME 1.662E-7 1.135E-6 7.084E-6 4.769E-5 7 367
43 1269283 DAP12 interactions BioSystems: REACTOME 1.890E-7 1.262E-6 7.870E-6 5.425E-5 7 374
44 1269478 Signaling by PDGF BioSystems: REACTOME 2.069E-7 1.350E-6 8.420E-6 5.938E-5 7 379
45 1269460 NGF signalling via TRKA from the plasma membrane BioSystems: REACTOME 2.514E-7 1.603E-6 1.000E-5 7.215E-5 7 390
46 126909 Oocyte meiosis BioSystems: KEGG 3.616E-7 2.256E-6 1.408E-5 1.038E-4 5 124
47 1269440 SOS-mediated signalling BioSystems: REACTOME 3.984E-7 2.287E-6 1.427E-5 1.144E-4 6 248
48 1269383 SHC1 events in EGFR signaling BioSystems: REACTOME 3.984E-7 2.287E-6 1.427E-5 1.144E-4 6 248
49 1269382 GRB2 events in EGFR signaling BioSystems: REACTOME 3.984E-7 2.287E-6 1.427E-5 1.144E-4 6 248
50 1269285 RAF/MAP kinase cascade BioSystems: REACTOME 3.984E-7 2.287E-6 1.427E-5 1.144E-4 6 248
Show 45 more annotations

8: Pubmed [Display Chart] 16 input genes in category / 2677 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19776387 The presence and activation of two essential transcription factors (cAMP response element-binding protein and cAMP-dependent transcription factor ATF1) in the two-cell mouse embryo. Pubmed 3.899E-19 1.044E-15 8.841E-15 1.044E-15 6 10
2 20668654 Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. Pubmed 1.354E-16 1.813E-13 1.535E-12 3.625E-13 5 7
3 11395482 Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. Pubmed 2.053E-14 1.374E-11 1.164E-10 5.496E-11 4 4
4 9822657 Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. Pubmed 2.053E-14 1.374E-11 1.164E-10 5.496E-11 4 4
5 11867766 Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. Pubmed 1.026E-13 5.495E-11 4.654E-10 2.747E-10 4 5
6 16512683 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Pubmed 1.922E-13 8.574E-11 7.262E-10 5.145E-10 7 157
7 17114649 Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Pubmed 3.458E-13 1.323E-10 1.120E-9 9.258E-10 8 330
8 9115241 Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II. Pubmed 7.181E-13 2.403E-10 2.035E-9 1.922E-9 4 7
9 11264466 Ca(2+)/CaM-dependent kinases: from activation to function. Pubmed 1.436E-12 3.843E-10 3.255E-9 3.843E-9 4 8
10 17202341 IL-10 regulation by HIV-Tat in primary human monocytic cells: involvement of calmodulin/calmodulin-dependent protein kinase-activated p38 MAPK and Sp-1 and CREB-1 transcription factors. Pubmed 1.436E-12 3.843E-10 3.255E-9 3.843E-9 4 8
11 17568776 Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. Pubmed 4.305E-12 1.048E-9 8.874E-9 1.152E-8 4 10
12 18945891 Synapsin IIa controls the reserve pool of glutamatergic synaptic vesicles. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
13 15601943 Different presynaptic roles of synapsins at excitatory and inhibitory synapses. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
14 27515700 DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
15 19487674 ERK activation in axonal varicosities modulates presynaptic plasticity in the CA3 region of the hippocampus through synapsin I. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
16 19605628 BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
17 23280234 Autism-related behavioral abnormalities in synapsin knockout mice. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
18 23236212 Epileptic synapsin triple knockout mice exhibit progressive long-term aberrant plasticity in the entorhinal cortex. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
19 22846639 Temporal evolution of neurophysiological and behavioral features of synapsin I/II/III triple knock-out mice. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
20 18077680 Synaptic vesicle mobility in mouse motor nerve terminals with and without synapsin. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
21 22368083 Synaptic and extrasynaptic origin of the excitation/inhibition imbalance in the hippocampus of synapsin I/II/III knockout mice. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
22 22442064 Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
23 10578110 Molecular evolution of the synapsin gene family. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
24 20804820 Cortico-hippocampal hyperexcitability in synapsin I/II/III knockout mice: age-dependency and response to the antiepileptic drug levetiracetam. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
25 16554471 Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
26 28922833 The Knockout of Synapsin II in Mice Impairs Social Behavior and Functional Connectivity Generating an ASD-like Phenotype. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
27 28245069 Synapsins regulate brain-derived neurotrophic factor-mediated synaptic potentiation and axon elongation by acting on membrane rafts. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
28 22933803 Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
29 27335405 Synapsin Isoforms Regulating GABA Release from Hippocampal Interneurons. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
30 16247765 Increased expression of calcium/calmodulin-dependent protein kinase IIbeta in frontal cortex in schizophrenia and depression. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
31 9882483 Calcium/calmodulin-dependent protein kinase II and calmodulin: regulators of the meiotic spindle in mouse eggs. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
32 12554746 Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
33 20660258 Synapsins differentially control dopamine and serotonin release. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
34 8939606 Impaired learning in mice with abnormal short-lived plasticity. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
35 21621590 Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
36 22805168 Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission. Pubmed 6.031E-11 4.485E-9 3.799E-8 1.615E-7 3 3
37 11889801 [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions]. Pubmed 2.412E-10 1.575E-8 1.334E-7 6.457E-7 3 4
38 17367784 Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells. Pubmed 2.412E-10 1.575E-8 1.334E-7 6.457E-7 3 4
39 14722083 Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. Pubmed 2.412E-10 1.575E-8 1.334E-7 6.457E-7 3 4
40 10381553 Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system. Pubmed 2.412E-10 1.575E-8 1.334E-7 6.457E-7 3 4
41 19233146 Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice. Pubmed 2.412E-10 1.575E-8 1.334E-7 6.457E-7 3 4
42 27507650 Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Pubmed 4.505E-10 2.871E-8 2.432E-7 1.206E-6 6 241
43 21209221 Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain. Pubmed 6.028E-10 3.293E-8 2.790E-7 1.614E-6 3 5
44 18218981 Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Pubmed 6.028E-10 3.293E-8 2.790E-7 1.614E-6 3 5
45 11160423 Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin. Pubmed 6.028E-10 3.293E-8 2.790E-7 1.614E-6 3 5
46 16436603 Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B. Pubmed 6.028E-10 3.293E-8 2.790E-7 1.614E-6 3 5
47 10358015 Homo- and heterodimerization of synapsins. Pubmed 6.028E-10 3.293E-8 2.790E-7 1.614E-6 3 5
48 10571231 A phospho-switch controls the dynamic association of synapsins with synaptic vesicles. Pubmed 6.028E-10 3.293E-8 2.790E-7 1.614E-6 3 5
49 11013247 Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein. Pubmed 6.028E-10 3.293E-8 2.790E-7 1.614E-6 3 5
50 28706196 Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Pubmed 6.943E-10 3.717E-8 3.148E-7 1.859E-6 6 259
Show 45 more annotations

9: Interaction [Display Chart] 16 input genes in category / 728 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SYN3 SYN3 interactions 2.223E-12 1.618E-9 1.160E-8 1.618E-9 4 5
2 int:SYN1 SYN1 interactions 7.399E-12 2.693E-9 1.931E-8 5.387E-9 6 58
3 int:NOS1 NOS1 interactions 2.517E-10 6.108E-8 4.378E-7 1.832E-7 5 42
4 int:ARMC1 ARMC1 interactions 3.610E-10 6.569E-8 4.709E-7 2.628E-7 5 45
5 int:SYN2 SYN2 interactions 1.351E-9 1.967E-7 1.410E-6 9.835E-7 4 18
6 int:CAMK2N2 CAMK2N2 interactions 6.051E-9 7.341E-7 5.262E-6 4.405E-6 3 5
7 int:DNAAF2 DNAAF2 interactions 8.410E-9 8.747E-7 6.270E-6 6.123E-6 5 83
8 int:CAMKK2 CAMKK2 interactions 1.792E-8 1.631E-6 1.169E-5 1.305E-5 4 33
9 int:CAMK2A CAMK2A interactions 2.055E-8 1.662E-6 1.191E-5 1.496E-5 5 99
10 int:CAMK1 CAMK1 interactions 3.590E-8 2.614E-6 1.874E-5 2.614E-5 4 39
11 int:ITPKA ITPKA interactions 9.950E-8 6.585E-6 4.721E-5 7.244E-5 3 11
12 int:NOS1AP NOS1AP interactions 1.269E-7 7.300E-6 5.233E-5 9.235E-5 4 53
13 int:SYNGAP1 SYNGAP1 interactions 1.304E-7 7.300E-6 5.233E-5 9.491E-5 5 143
14 int:DLGAP1 DLGAP1 interactions 2.825E-7 1.469E-5 1.053E-4 2.057E-4 5 167
15 int:CAMK2G CAMK2G interactions 3.499E-7 1.698E-5 1.217E-4 2.547E-4 4 68
16 int:KALRN KALRN interactions 3.935E-7 1.791E-5 1.284E-4 2.865E-4 4 70
17 int:DGUOK DGUOK interactions 4.664E-7 1.997E-5 1.432E-4 3.395E-4 4 73
18 int:AGAP2 AGAP2 interactions 5.794E-7 2.343E-5 1.680E-4 4.218E-4 5 193
19 int:LRRC7 LRRC7 interactions 9.231E-7 3.537E-5 2.535E-4 6.720E-4 3 22
20 int:GRIN2B GRIN2B interactions 1.466E-6 5.334E-5 3.824E-4 1.067E-3 4 97
21 int:GRIN1 GRIN1 interactions 2.606E-6 9.033E-5 6.475E-4 1.897E-3 4 112
22 int:CAMKK1 CAMKK1 interactions 2.957E-6 9.784E-5 7.013E-4 2.153E-3 3 32
23 int:TNIK TNIK interactions 3.745E-6 1.185E-4 8.497E-4 2.726E-3 5 282
24 int:HAX1 HAX1 interactions 7.280E-6 2.047E-4 1.468E-3 5.300E-3 4 145
25 int:GRIN2A GRIN2A interactions 7.312E-6 2.047E-4 1.468E-3 5.323E-3 3 43
26 int:ATF1 ATF1 interactions 7.312E-6 2.047E-4 1.468E-3 5.323E-3 3 43
27 int:SHANK3 SHANK3 interactions 1.243E-5 3.351E-4 2.402E-3 9.048E-3 4 166
28 int:TSC1 TSC1 interactions 1.303E-5 3.388E-4 2.428E-3 9.486E-3 4 168
29 int:CNKSR2 CNKSR2 interactions 1.461E-5 3.667E-4 2.629E-3 1.063E-2 3 54
30 int:GRM4 GRM4 interactions 1.604E-5 3.710E-4 2.659E-3 1.168E-2 2 7
31 int:ADCY8 ADCY8 interactions 1.604E-5 3.710E-4 2.659E-3 1.168E-2 2 7
32 int:ARHGEF7 ARHGEF7 interactions 1.631E-5 3.710E-4 2.659E-3 1.187E-2 3 56
33 int:C11orf65 C11orf65 interactions 2.747E-5 6.060E-4 4.344E-3 2.000E-2 2 9
34 int:RALA RALA interactions 3.625E-5 7.761E-4 5.563E-3 2.639E-2 3 73
35 int:CAMK2B CAMK2B interactions 3.931E-5 8.176E-4 5.861E-3 2.862E-2 3 75
36 int:PATJ PATJ interactions 4.090E-5 8.248E-4 5.913E-3 2.978E-2 3 76
37 int:KCNQ2 KCNQ2 interactions 4.192E-5 8.248E-4 5.913E-3 3.052E-2 2 11
38 int:DLG3 DLG3 interactions 5.520E-5 1.057E-3 7.580E-3 4.018E-2 3 84
39 int:RCHY1 RCHY1 interactions 5.718E-5 1.067E-3 7.651E-3 4.163E-2 3 85
40 int:CHAT CHAT interactions 5.939E-5 1.081E-3 7.748E-3 4.324E-2 2 13
41 int:RRAD RRAD interactions 7.986E-5 1.384E-3 9.923E-3
5.814E-2
 2 15
42 int:RYR1 RYR1 interactions 7.986E-5 1.384E-3 9.923E-3
5.814E-2
 2 15
43 int:DLG4 DLG4 interactions 8.824E-5 1.491E-3 1.069E-2
6.424E-2
 4 274
44 int:GIT1 GIT1 interactions 9.011E-5 1.491E-3 1.069E-2
6.560E-2
 3 99
45 int:PRKACA PRKACA interactions 9.999E-5 1.618E-3 1.160E-2
7.280E-2
 4 283
46 int:CAMK2D CAMK2D interactions 1.043E-4 1.651E-3 1.184E-2
7.595E-2
 3 104
47 int:CAMK4 CAMK4 interactions 1.441E-4 2.233E-3 1.600E-2
1.049E-1
 2 20
48 int:NUFIP1 NUFIP1 interactions 1.480E-4 2.244E-3 1.609E-2
1.077E-1
 3 117
49 int:MYLK MYLK interactions 1.916E-4 2.847E-3 2.041E-2
1.395E-1
 2 23
50 int:CALM1 CALM1 interactions 2.119E-4 3.086E-3 2.212E-2
1.543E-1
 4 344
Show 45 more annotations

10: Cytoband [Display Chart] 16 input genes in category / 16 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7p14.3-p14.1 7p14.3-p14.1 9.230E-4 1.477E-2 4.993E-2 1.477E-2 1 2
2 Xp22.12 Xp22.12 3.687E-3 1.747E-2
5.907E-2
5.900E-2
 1 8
3 5q21.3 5q21.3 6.903E-3 1.747E-2
5.907E-2
1.105E-1
 1 15
4 12q24.2 12q24.2 7.362E-3 1.747E-2
5.907E-2
1.178E-1
 1 16
5 3p25 3p25 7.820E-3 1.747E-2
5.907E-2
1.251E-1
 1 17
6 11q24.3 11q24.3 7.820E-3 1.747E-2
5.907E-2
1.251E-1
 1 17
7 14q32.11 14q32.11 8.737E-3 1.747E-2
5.907E-2
1.398E-1
 1 19
8 10q22 10q22 8.737E-3 1.747E-2
5.907E-2
1.398E-1
 1 19
9 12q24 12q24 1.148E-2 2.041E-2
6.900E-2
1.837E-1
 1 25
10 22q12.3 22q12.3 1.649E-2 2.465E-2
8.334E-2
2.639E-1
 1 36
11 16p12.2 16p12.2 1.695E-2 2.465E-2
8.334E-2
2.712E-1
 1 37
12 3p25.3 3p25.3 2.103E-2 2.804E-2
9.479E-2
3.365E-1
 1 46
13 1q23.3 1q23.3 2.329E-2 2.866E-2
9.690E-2
3.726E-1
 1 51
14 5q32 5q32 2.509E-2 2.868E-2
9.696E-2
4.015E-1
 1 55
15 2p21 2p21 2.959E-2 3.157E-2
1.067E-1
4.735E-1
 1 65
16 Xp11.23 Xp11.23 4.563E-2 4.563E-2
1.543E-1
7.300E-1
 1 101
Show 11 more annotations

11: Transcription Factor Binding Site [Display Chart] 15 input genes in category / 133 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 8 input genes in category / 8 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1325 Synapsins genenames.org 5.580E-11 4.464E-10 1.213E-9 4.464E-10 3 3
2 214 Purinergic receptors P2X|Deafness associated genes genenames.org 3.074E-3 8.985E-3 2.442E-2 2.460E-2 1 7
3 863 EF-hand domain containing genenames.org 3.850E-3 8.985E-3 2.442E-2 3.080E-2 2 219
4 542 Endogenous ligands genenames.org 4.493E-3 8.985E-3 2.442E-2 3.594E-2 2 237
5 721 Rho GTPase activating proteins genenames.org 2.178E-2 3.485E-2
9.471E-2
1.742E-1
 1 50

13: Coexpression [Display Chart] 16 input genes in category / 1312 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M9112 Age down-regulated genes in the human frontal cortex. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.145E-6 2.457E-3 1.906E-2 4.127E-3 4 153
2 12471243-TableS2 Human Manning02 624genes ProteinKinases GeneSigDB 3.746E-6 2.457E-3 1.906E-2 4.915E-3 5 368
3 M1712 Genes enriched in neurons in the adult mouse brain identified through correlation-based searches seeded with neuron cell-type specific gene expression patterns. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.383E-5 6.046E-3 4.690E-2 1.814E-2 3 69
4 12946996-Table2 Human Lymphoma Kaminski03 16genes GeneSigDB 2.457E-5 7.613E-3
5.905E-2
 3.224E-2 2 11
5 20459861-TableS3b Human Leukemia Cleaver10 12genes GeneSigDB 2.947E-5 7.613E-3
5.905E-2
 3.867E-2 2 12
6 19286929-SuppTable2c Mouse Lung Rangasamy09 13genes GeneSigDB 3.482E-5 7.613E-3
5.905E-2
 4.568E-2 2 13
7 M5252 Genes up-regulated in comparison of macrophages exposed to L. major versus macrophages exposed to M. tuberculosis. MSigDB C7: Immunologic Signatures (v6.0) 3.091E-4 3.911E-2
3.034E-1
4.055E-1
 3 196
8 M10033 Genes down-regulated in macrophages: control versus colorectal adenocarcinoma conditioned. MSigDB C7: Immunologic Signatures (v6.0) 3.231E-4 3.911E-2
3.034E-1
4.240E-1
 3 199
9 M5215 Genes up-regulated in comparison of dendritic cells (DC) exposed to T. gondii versus DCs exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 3.231E-4 3.911E-2
3.034E-1
4.240E-1
 3 199
10 M8653 Genes up-regulated in P14 CD8+ T cells: ST2 [GeneID=6761] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 3.279E-4 3.911E-2
3.034E-1
4.302E-1
 3 200
11 M5151 Genes down-regulated in comparison of dendritic cells (DC) versus DCs exposed to B. malayi (50 worms/well). MSigDB C7: Immunologic Signatures (v6.0) 3.279E-4 3.911E-2
3.034E-1
4.302E-1
 3 200
12 17823248-Table2 Mouse Breast VanHouten07 49genes GeneSigDB 4.362E-4 4.048E-2
3.140E-1
5.723E-1
 2 45
13 M1240 Genes down-regulated in early vs late brain tumors induced by retroviral delivery of PDGFB [GeneID=5155]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.362E-4 4.048E-2
3.140E-1
5.723E-1
 2 45
14 17823277-Table2 Human Placenta Cindrova-Davies07 93genes GeneSigDB 4.559E-4 4.048E-2
3.140E-1
5.981E-1
 2 46
15 M11234 Genes down-regulated in polymorphonuclear neutrophilic granulocytes (PMNs) attracted to skin wounds. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.628E-4 4.048E-2
3.140E-1
6.072E-1
 3 225
Show 10 more annotations

14: Coexpression Atlas [Display Chart] 16 input genes in category / 1129 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup5 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup5 Top 200 Genes BrainMap 3.644E-10 1.778E-7 1.352E-6 4.114E-7 7 264
2 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup6 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup6 Top 200 Genes BrainMap 4.488E-10 1.778E-7 1.352E-6 5.067E-7 7 272
3 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup4 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup4 Top 200 Genes BrainMap 4.723E-10 1.778E-7 1.352E-6 5.333E-7 7 274
4 BrainMap BrainAtlas - Human / Mouse Linnarsson Neuron Neuron Subtype Excitatory Top 200 Genes BrainMap BrainAtlas - Human / Mouse Linnarsson Neuron Neuron Subtype Excitatory Top 200 Genes BrainMap 9.743E-10 2.249E-7 1.710E-6 1.100E-6 7 304
5 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.mixed excitatory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.mixed excitatory Top 200 Genes BrainMap 1.167E-9 2.249E-7 1.710E-6 1.318E-6 7 312
6 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 PosteriorCortex Top 200 Genes BrainMap 1.618E-9 2.249E-7 1.710E-6 1.826E-6 7 327
7 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 PosteriorCortex Top 200 Genes BrainMap 1.618E-9 2.249E-7 1.710E-6 1.826E-6 7 327
8 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Slc17a7 Neuron.mixed excitatory.Slc17a7 Subtype Neuron.mixed excitatory.Slc17a7 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Slc17a7 Neuron.mixed excitatory.Slc17a7 Subtype Neuron.mixed excitatory.Slc17a7 FrontalCortex Top 200 Genes BrainMap 1.874E-9 2.249E-7 1.710E-6 2.116E-6 7 334
9 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Overall Top 200 Genes BrainMap 2.808E-9 2.249E-7 1.710E-6 3.170E-6 6 188
10 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Overall Top 200 Genes BrainMap 2.808E-9 2.249E-7 1.710E-6 3.170E-6 6 188
11 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup6 Excitatory.subGroup6 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup6 Excitatory.subGroup6 Overall Top 200 Genes BrainMap 2.808E-9 2.249E-7 1.710E-6 3.170E-6 6 188
12 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup6 Excitatory.subGroup6 Top 200 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup6 Excitatory.subGroup6 Top 200 BrainMap 2.808E-9 2.249E-7 1.710E-6 3.170E-6 6 188
13 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Overall Top 200 Genes BrainMap 2.993E-9 2.249E-7 1.710E-6 3.379E-6 6 190
14 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Overall Top 200 Genes BrainMap 3.088E-9 2.249E-7 1.710E-6 3.487E-6 6 191
15 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Overall Top 200 Genes BrainMap 3.088E-9 2.249E-7 1.710E-6 3.487E-6 6 191
16 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Slc17a7 Neuron.mixed excitatory.Slc17a7 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Slc17a7 Neuron.mixed excitatory.Slc17a7 Overall Top 200 Genes BrainMap 3.187E-9 2.249E-7 1.710E-6 3.598E-6 6 192
17 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup7 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup7 Top 200 Genes BrainMap 7.205E-9 4.785E-7 3.640E-6 8.135E-6 6 220
18 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup2 Top 200 Genes BrainMap 7.813E-9 4.901E-7 3.728E-6 8.821E-6 6 223
19 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Slc17a7 Neuron.mixed excitatory.Slc17a7 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Slc17a7 Neuron.mixed excitatory.Slc17a7 Top 200 BrainMap 1.449E-8 8.611E-7 6.550E-6 1.636E-5 7 449
20 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Syt6,Fos Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Syt6,Fos Top 200 Genes BrainMap 2.139E-8 1.207E-6 9.185E-6 2.415E-5 6 264
21 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup3 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup3 Top 200 Genes BrainMap 3.234E-8 1.739E-6 1.322E-5 3.651E-5 6 283
22 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 GlobusPallidus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 GlobusPallidus Top 200 Genes BrainMap 3.894E-8 1.999E-6 1.520E-5 4.397E-5 6 292
23 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Syt6,Slc24a2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Syt6,Slc24a2 Top 200 Genes BrainMap 4.222E-8 2.072E-6 1.576E-5 4.767E-5 6 296
24 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.excitatory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.excitatory Top 200 Genes BrainMap 4.663E-8 2.106E-6 1.602E-5 5.265E-5 6 301
25 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7 Top 200 Genes 4.663E-8 2.106E-6 1.602E-5 5.265E-5 6 301
26 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype mixed excitatory.Slc17a7 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype mixed excitatory.Slc17a7 Top 200 Genes 4.850E-8 2.106E-6 1.602E-5 5.476E-5 6 303
27 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7,Slc17a8 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7,Slc17a8 Top 200 Genes BrainMap 5.344E-8 2.235E-6 1.700E-5 6.033E-5 6 308
28 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup1 Top 200 Genes BrainMap 5.769E-8 2.289E-6 1.741E-5 6.513E-5 6 312
29 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7 Top 200 Genes BrainMap 5.879E-8 2.289E-6 1.741E-5 6.638E-5 6 313
30 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Slc17a7 Neuron.mixed excitatory.Slc17a7 Subtype Neuron.mixed excitatory.Slc17a7 Hippocampus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Slc17a7 Neuron.mixed excitatory.Slc17a7 Subtype Neuron.mixed excitatory.Slc17a7 Hippocampus Top 200 Genes BrainMap 6.579E-8 2.423E-6 1.843E-5 7.428E-5 6 319
31 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Parm1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Parm1 Top 200 Genes BrainMap 6.702E-8 2.423E-6 1.843E-5 7.567E-5 6 320
32 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7,Slc17a6 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7,Slc17a6 Top 200 Genes 6.954E-8 2.423E-6 1.843E-5 7.851E-5 6 322
33 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Gad1,Gad2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Gad1,Gad2 Top 200 Genes BrainMap 7.083E-8 2.423E-6 1.843E-5 7.996E-5 6 323
34 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 FrontalCortex Top 200 Genes BrainMap 7.481E-8 2.484E-6 1.890E-5 8.446E-5 6 326
35 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a6 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a6 Top 200 Genes BrainMap 9.931E-8 3.027E-6 2.303E-5 1.121E-4 6 342
36 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7,Slc17a6 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7,Slc17a6 Top 200 Genes BrainMap 9.931E-8 3.027E-6 2.303E-5 1.121E-4 6 342
37 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a6,Slc17a7 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a6,Slc17a7 Top 200 Genes BrainMap 1.010E-7 3.027E-6 2.303E-5 1.141E-4 6 343
38 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Slc17a7 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Slc17a7 Top 200 Genes BrainMap 1.028E-7 3.027E-6 2.303E-5 1.161E-4 6 344
39 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 Hippocampus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 Hippocampus Top 200 Genes BrainMap 1.046E-7 3.027E-6 2.303E-5 1.181E-4 6 345
40 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 FrontalCortex Top 200 Genes BrainMap 1.197E-7 3.379E-6 2.571E-5 1.352E-4 6 353
41 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 Hippocampus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 Hippocampus Top 200 Genes BrainMap 1.367E-7 3.763E-6 2.862E-5 1.543E-4 6 361
42 BrainMap BrainAtlas - Mouse McCarroll Mural.Rgs5.Acta2.Acta2,Rgs5 Mural.Rgs5.Acta2.Acta2,Rgs5 Subtype Mural.Rgs5.Acta2.Acta2,Rgs5 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Mural.Rgs5.Acta2.Acta2,Rgs5 Mural.Rgs5.Acta2.Acta2,Rgs5 Subtype Mural.Rgs5.Acta2.Acta2,Rgs5 FrontalCortex Top 200 Genes BrainMap 1.506E-7 4.048E-6 3.079E-5 1.700E-4 6 367
43 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Overall Top 200 Genes BrainMap 1.817E-7 4.579E-6 3.483E-5 2.051E-4 5 188
44 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Top 200 BrainMap 1.817E-7 4.579E-6 3.483E-5 2.051E-4 5 188
45 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid/neuron Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid/neuron Tabula Muris Consortium 1.866E-7 4.579E-6 3.483E-5 2.106E-4 5 189
46 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Overall Top 200 Genes BrainMap 1.866E-7 4.579E-6 3.483E-5 2.106E-4 5 189
47 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/mixed excitatory BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/mixed excitatory BrainMap 1.915E-7 4.600E-6 3.499E-5 2.162E-4 5 190
48 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Top 200 BrainMap 6.930E-7 1.630E-5 1.240E-4 7.824E-4 6 476
49 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Top 200 BrainMap 8.916E-7 2.054E-5 1.563E-4 1.007E-3 6 497
50 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Subtype Excitatory.subGroup5 PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Subtype Excitatory.subGroup5 PosteriorCortex Top 200 Genes BrainMap 1.713E-6 3.868E-5 2.942E-4 1.934E-3 5 296
Show 45 more annotations

15: Computational [Display Chart] 14 input genes in category / 140 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3373 GNF2 DNM1 Neighborhood of DNM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.269E-4 1.255E-2
6.931E-2
 1.776E-2 3 73
2 M15252 GCM MAPK10 Neighborhood of MAPK10 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.793E-4 1.255E-2
6.931E-2
 2.510E-2 3 82

16: MicroRNA [Display Chart] 16 input genes in category / 776 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-634:PITA hsa-miR-634:PITA TOP PITA 3.453E-7 2.679E-4 1.938E-3 2.679E-4 4 272
2 hsa-miR-133a-3p.1:TargetScan hsa-miR-133a-3p.1 TargetScan 1.832E-6 7.109E-4 5.141E-3 1.422E-3 4 414
3 hsa-miR-335-5p:TargetScan hsa-miR-335-5p TargetScan 1.415E-5 2.795E-3 2.021E-2 1.098E-2 3 215
4 hsa-miR-1246:PITA hsa-miR-1246:PITA TOP PITA 1.798E-5 2.795E-3 2.021E-2 1.395E-2 3 233
5 hsa-miR-520a-5p:PITA hsa-miR-520a-5p:PITA TOP PITA 2.245E-5 2.795E-3 2.021E-2 1.742E-2 3 251
6 hsa-miR-525-5p:PITA hsa-miR-525-5p:PITA TOP PITA 2.245E-5 2.795E-3 2.021E-2 1.742E-2 3 251
7 hsa-miR-1827:PITA hsa-miR-1827:PITA TOP PITA 2.521E-5 2.795E-3 2.021E-2 1.957E-2 3 261
8 hsa-miR-1296:PITA hsa-miR-1296:PITA TOP PITA 3.570E-5 3.462E-3 2.504E-2 2.770E-2 2 40
9 hsa-miR-338-3p:TargetScan hsa-miR-338-3p TargetScan 5.199E-5 4.404E-3 3.185E-2 4.034E-2 3 333
10 hsa-miR-153:PITA hsa-miR-153:PITA TOP PITA 5.675E-5 4.404E-3 3.185E-2 4.404E-2 3 343
11 hsa-miR-603:PITA hsa-miR-603:PITA TOP PITA 7.988E-5 5.635E-3 4.075E-2
6.199E-2
 3 385
12 hsa-miR-1227:mirSVR highEffct hsa-miR-1227:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.011E-4 5.823E-3 4.211E-2
7.847E-2
 3 417
13 hsa-miR-876-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.165E-4 5.823E-3 4.211E-2
9.040E-2
 2 72
14 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 1.169E-4 5.823E-3 4.211E-2
9.071E-2
 3 438
15 hsa-miR-3167:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.198E-4 5.823E-3 4.211E-2
9.293E-2
 2 73
16 hsa-miR-544:PITA hsa-miR-544:PITA TOP PITA 1.201E-4 5.823E-3 4.211E-2
9.317E-2
 3 442
17 hsa-miR-4662a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.333E-4 6.083E-3 4.399E-2
1.034E-1
 2 77
18 hsa-miR-181a-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.512E-4 6.517E-3 4.713E-2
1.173E-1
 2 82
19 hsa-miR-4301:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.663E-4 6.791E-3 4.911E-2
1.290E-1
 2 86
20 hsa-miR-6509-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.821E-4 7.066E-3
5.110E-2
1.413E-1
 2 90
21 hsa-let-7c-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.293E-4 8.360E-3
6.046E-2
1.779E-1
 2 101
22 hsa-miR-6743-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.431E-4 8.360E-3
6.046E-2
1.886E-1
 2 104
23 hsa-miR-4688:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.478E-4 8.360E-3
6.046E-2
1.923E-1
 2 105
24 hsa-miR-589:PITA hsa-miR-589:PITA TOP PITA 3.127E-4 1.011E-2
7.313E-2
2.427E-1
 2 118
25 hsa-miR-3156-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.342E-4 1.014E-2
7.332E-2
2.594E-1
 2 122
26 hsa-miR-876-3p:PITA hsa-miR-876-3p:PITA TOP PITA 3.397E-4 1.014E-2
7.332E-2
2.636E-1
 2 123
27 CAGCCTC,MIR-485-5P:MSigDB CAGCCTC,MIR-485-5P:MSigDB MSigDB 3.793E-4 1.067E-2
7.719E-2
2.943E-1
 2 130
28 hsa-miR-1324:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.851E-4 1.067E-2
7.719E-2
2.989E-1
 2 131
29 CTCTGGA,MIR-520A:MSigDB CTCTGGA,MIR-520A:MSigDB MSigDB 4.458E-4 1.153E-2
8.340E-2
3.460E-1
 2 141
30 CTCTGGA,MIR-525:MSigDB CTCTGGA,MIR-525:MSigDB MSigDB 4.458E-4 1.153E-2
8.340E-2
3.460E-1
 2 141
31 hsa-miR-2116-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.520E-4 1.303E-2
9.420E-2
4.284E-1
 2 157
32 hsa-miR-628-5p:PITA hsa-miR-628-5p:PITA TOP PITA 5.661E-4 1.303E-2
9.420E-2
4.393E-1
 2 159
33 hsa-miR-943:PITA hsa-miR-943:PITA TOP PITA 5.732E-4 1.303E-2
9.420E-2
4.448E-1
 2 160
34 hsa-miR-579-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.732E-4 1.303E-2
9.420E-2
4.448E-1
 2 160
35 hsa-miR-664b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.875E-4 1.303E-2
9.420E-2
4.559E-1
 2 162
36 hsa-miR-3680-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.082E-4 1.517E-2
1.097E-1
5.495E-1
 2 178
37 hsa-miR-765:PITA hsa-miR-765:PITA TOP PITA 7.482E-4 1.517E-2
1.097E-1
5.806E-1
 2 183
38 hsa-miR-557:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.892E-4 1.517E-2
1.097E-1
6.124E-1
 2 188
39 hsa-miR-507:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.892E-4 1.517E-2
1.097E-1
6.124E-1
 2 188
40 hsa-miR-337-3p:PITA hsa-miR-337-3p:PITA TOP PITA 8.313E-4 1.517E-2
1.097E-1
6.451E-1
 2 193
41 hsa-let-7d*:mirSVR highEffct hsa-let-7d*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.485E-4 1.517E-2
1.097E-1
6.584E-1
 2 195
42 hsa-miR-196a:PITA hsa-miR-196a:PITA TOP PITA 8.745E-4 1.517E-2
1.097E-1
6.786E-1
 2 198
43 hsa-miR-196b:PITA hsa-miR-196b:PITA TOP PITA 8.745E-4 1.517E-2
1.097E-1
6.786E-1
 2 198
44 hsa-miR-7851-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.833E-4 1.517E-2
1.097E-1
6.854E-1
 2 199
45 hsa-miR-425-5p:TargetScan hsa-miR-425-5p TargetScan 9.098E-4 1.517E-2
1.097E-1
7.060E-1
 2 202
46 CTATGCA,MIR-153:MSigDB CTATGCA,MIR-153:MSigDB MSigDB 9.098E-4 1.517E-2
1.097E-1
7.060E-1
 2 202
47 hsa-miR-450b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.187E-4 1.517E-2
1.097E-1
7.129E-1
 2 203
48 hsa-miR-5580-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.825E-4 1.554E-2
1.124E-1
7.624E-1
 2 210
49 hsa-miR-576-3p:PITA hsa-miR-576-3p:PITA TOP PITA 1.020E-3 1.554E-2
1.124E-1
7.914E-1
 2 214
50 hsa-miR-532-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.077E-3 1.554E-2
1.124E-1
8.358E-1
 2 220
Show 45 more annotations

17: Drug [Display Chart] 16 input genes in category / 4630 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID006439511 HF-2035 Stitch 4.998E-24 2.314E-20 2.087E-19 2.314E-20 9 25
2 CID000003837 AC1L1GTT Stitch 4.101E-19 9.493E-16 8.560E-15 1.899E-15 11 233
3 CID000003007 amphetamine Stitch 5.652E-16 8.724E-13 7.867E-12 2.617E-12 10 284
4 CID000003838 KN-62 Stitch 9.790E-15 1.133E-11 1.022E-10 4.533E-11 9 230
5 CID000002531 calmidazolium chloride Stitch 5.964E-14 5.522E-11 4.980E-10 2.761E-10 8 160
6 CID000129400 K-II Stitch 2.057E-13 1.587E-10 1.431E-9 9.522E-10 7 96
7 CID000848641 2brh Stitch 1.705E-12 1.128E-9 1.017E-8 7.896E-9 5 21
8 CID000005681 W7 hydrochloride Stitch 2.197E-12 1.258E-9 1.135E-8 1.017E-8 8 250
9 CID000196705 alpha-CaM Stitch 2.446E-12 1.258E-9 1.135E-8 1.132E-8 6 62
10 CID000131117 Kn 04 Stitch 5.502E-12 2.390E-9 2.155E-8 2.547E-8 5 26
11 CID005074902 syntide-2 Stitch 5.679E-12 2.390E-9 2.155E-8 2.629E-8 6 71
12 CID000123712 18-oxocortisol Stitch 8.214E-12 3.169E-9 2.858E-8 3.803E-8 5 28
13 CID000123655 AC1L3X1Y Stitch 1.418E-11 5.051E-9 4.555E-8 6.567E-8 5 31
14 CID000000049 alpha-ketoisovalerate Stitch 2.289E-11 7.569E-9 6.825E-8 1.060E-7 6 89
15 CID000010800 DNOC Stitch 2.705E-11 8.351E-9 7.530E-8 1.253E-7 5 35
16 CID000011222 18-hydroxycorticosterone Stitch 7.069E-11 2.046E-8 1.845E-7 3.273E-7 5 42
17 CID000005114 3-(1H-pyrrole-2-carboxylate Stitch 1.111E-10 3.027E-8 2.729E-7 5.145E-7 7 233
18 ctd:C063302 KN 62 CTD 1.272E-10 3.272E-8 2.951E-7 5.890E-7 5 47
19 CID000092266 2-nitro-5-thiocyanobenzoic acid Stitch 1.420E-10 3.459E-8 3.119E-7 6.573E-7 5 48
20 CID000003836 AC1L1GTQ Stitch 2.616E-10 6.055E-8 5.460E-7 1.211E-6 5 54
21 CID000004314 N-(6-aminohexyl)-1-naphthalenesulfonamide Stitch 3.459E-10 7.626E-8 6.877E-7 1.601E-6 5 57
22 ctd:D010622 Phencyclidine CTD 2.843E-9 5.984E-7 5.396E-6 1.317E-5 5 86
23 CID000003541 AC1MBZ1C Stitch 3.809E-9 7.668E-7 6.914E-6 1.764E-5 7 387
24 CID003467590 STO-609 Stitch 5.705E-9 1.101E-6 9.924E-6 2.641E-5 4 32
25 CID000002533 calphostin C Stitch 8.015E-9 1.484E-6 1.339E-5 3.711E-5 7 431
26 CID000104978 fluo-3 Stitch 1.668E-8 2.970E-6 2.679E-5 7.723E-5 5 122
27 CID005329102 sunitinib Stitch 2.296E-8 3.907E-6 3.523E-5 1.063E-4 5 130
28 ctd:D002186 Cannabinoids CTD 2.363E-8 3.907E-6 3.523E-5 1.094E-4 3 9
29 CID000002293 BAPTA-AM Stitch 3.106E-8 4.958E-6 4.471E-5 1.438E-4 6 294
30 CID000004697 AC1L1IR1 Stitch 4.971E-8 7.672E-6 6.918E-5 2.302E-4 4 54
31 CID000005566 trifluoperazine Stitch 5.629E-8 8.406E-6 7.581E-5 2.606E-4 6 325
32 ctd:D006220 Haloperidol CTD 7.878E-8 1.127E-5 1.016E-4 3.648E-4 6 344
33 CID000132706 SC-52458 Stitch 8.031E-8 1.127E-5 1.016E-4 3.718E-4 3 13
34 CID000012531 myristyl acetate Stitch 9.327E-8 1.270E-5 1.145E-4 4.319E-4 4 63
35 CID000052396 P-81 Stitch 1.022E-7 1.352E-5 1.219E-4 4.730E-4 3 14
36 ctd:D018967 Risperidone CTD 1.059E-7 1.362E-5 1.229E-4 4.904E-4 4 65
37 CID000005657 NSC7524 Stitch 1.237E-7 1.548E-5 1.396E-4 5.726E-4 5 182
38 ctd:D003024 Clozapine CTD 1.703E-7 2.075E-5 1.871E-4 7.885E-4 6 392
39 CID000003895 lavendustin B Stitch 3.722E-7 4.419E-5 3.984E-4 1.723E-3 3 21
40 CID002733635 Fm 4-64 Stitch 4.136E-7 4.787E-5 4.317E-4 1.915E-3 4 91
41 CID005288237 AC1NRB38 Stitch 9.140E-7 1.032E-4 9.308E-4 4.232E-3 3 28
42 CID006432217 HCOH (hydroxymethylene) Stitch 1.253E-6 1.349E-4 1.216E-3 5.799E-3 3 31
43 CID003336188 AC1MO08Q Stitch 1.253E-6 1.349E-4 1.216E-3 5.799E-3 3 31
44 CID000120726 delcosine Stitch 1.380E-6 1.359E-4 1.226E-3 6.387E-3 2 3
45 CID000163526 tatsiensine Stitch 1.380E-6 1.359E-4 1.226E-3 6.387E-3 2 3
46 CID004630710 AC1NDS53 Stitch 1.380E-6 1.359E-4 1.226E-3 6.387E-3 2 3
47 CID000339501 NSC366363 Stitch 1.380E-6 1.359E-4 1.226E-3 6.387E-3 2 3
48 CID000065909 CGS 9343B Stitch 1.519E-6 1.442E-4 1.300E-3 7.033E-3 3 33
49 CID000002162 amlodipine Stitch 1.526E-6 1.442E-4 1.300E-3 7.067E-3 4 126
50 CID000002104 AC1L1CXF Stitch 1.985E-6 1.799E-4 1.622E-3 9.192E-3 3 36
Show 45 more annotations

18: Disease [Display Chart] 16 input genes in category / 279 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0031391 Phencyclidine Abuse DisGeNET Curated 2.757E-8 6.884E-6 4.275E-5 7.693E-6 3 7
2 C0236736 Cocaine-Related Disorders DisGeNET Curated 4.935E-8 6.884E-6 4.275E-5 1.377E-5 5 108
3 C0454651 Specific language impairment DisGeNET BeFree 7.579E-7 7.048E-5 4.377E-4 2.115E-4 3 19
4 C0035828 Romano-Ward Syndrome DisGeNET Curated 1.382E-6 9.638E-5 5.986E-4 3.855E-4 3 23
5 C1141890 Congenital long QT syndrome DisGeNET BeFree 2.548E-6 1.274E-4 7.914E-4 7.110E-4 3 28
6 C3826614 Cardiac arrest in children DisGeNET BeFree 2.740E-6 1.274E-4 7.914E-4 7.646E-4 2 3
7 C0043168 Whooping cough due to unspecified organism DisGeNET BeFree 5.478E-6 2.183E-4 1.356E-3 1.528E-3 2 4
8 C1832526 CATARACT, NONNUCLEAR POLYMORPHIC CONGENITAL, AUTOSOMAL DOMINANT DisGeNET BeFree 9.124E-6 2.828E-4 1.757E-3 2.546E-3 2 5
9 C1833372 HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE III DisGeNET Curated 9.124E-6 2.828E-4 1.757E-3 2.546E-3 2 5
10 C1142166 Brugada Syndrome (disorder) DisGeNET Curated 1.247E-5 3.479E-4 2.161E-3 3.479E-3 3 47
11 C0043167 Pertussis DisGeNET BeFree 1.914E-5 4.854E-4 3.015E-3 5.340E-3 2 7
12 C0003469 Anxiety Disorders DisGeNET Curated 2.500E-5 5.378E-4 3.340E-3 6.974E-3 5 382
13 C0024809 Marijuana Abuse DisGeNET Curated 3.025E-5 5.378E-4 3.340E-3 8.439E-3 3 63
14 C0085612 Ventricular arrhythmia DisGeNET Curated 3.172E-5 5.378E-4 3.340E-3 8.849E-3 3 64
15 C3164344 Adult onset autosomal dominant leukodystrophy DisGeNET Curated 3.277E-5 5.378E-4 3.340E-3 9.143E-3 2 9
16 C0852975 congenital cerebellar ataxia DisGeNET BeFree 3.277E-5 5.378E-4 3.340E-3 9.143E-3 2 9
17 C1866423 Quebec platelet disorder DisGeNET Curated 3.277E-5 5.378E-4 3.340E-3 9.143E-3 2 9
18 C0023976 Long QT Syndrome DisGeNET Curated 3.806E-5 5.899E-4 3.663E-3 1.062E-2 3 68
19 C0795953 MASA SYNDROME (disorder) DisGeNET Curated 5.001E-5 6.976E-4 4.332E-3 1.395E-2 2 11
20 C0017926 Glycogen Storage Disease Type VII DisGeNET Curated 5.001E-5 6.976E-4 4.332E-3 1.395E-2 2 11
21 C0340493 Paroxysmal familial ventricular fibrillation DisGeNET Curated 8.260E-5 1.097E-3 6.815E-3 2.305E-2 2 14
22 C0595995 Idiopathic scoliosis DisGeNET BeFree 9.525E-5 1.208E-3 7.502E-3 2.658E-2 2 15
23 C0242594 Residual Cancer DisGeNET BeFree 1.088E-4 1.265E-3 7.854E-3 3.035E-2 2 16
24 C0403553 Renal dysplasia and retinal aplasia (disorder) DisGeNET Curated 1.088E-4 1.265E-3 7.854E-3 3.035E-2 2 16
25 C0151878 Prolonged QT interval DisGeNET Curated 1.232E-4 1.322E-3 8.212E-3 3.438E-2 2 17
26 C0265216 X-linked hydrocephalus syndrome DisGeNET Curated 1.232E-4 1.322E-3 8.212E-3 3.438E-2 2 17
27 C0035288 Reticuloendotheliosis, X-linked DisGeNET BeFree 1.386E-4 1.381E-3 8.574E-3 3.866E-2 2 18
28 C0001818 Agoraphobia DisGeNET Curated 1.386E-4 1.381E-3 8.574E-3 3.866E-2 2 18
29 C0410538 Pseudoachondroplasia DisGeNET Curated 1.548E-4 1.489E-3 9.247E-3 4.318E-2 2 19
30 C0020429 Hyperalgesia DisGeNET Curated 1.641E-4 1.527E-3 9.480E-3 4.580E-2 3 111
31 C0026760 Multiple Epiphyseal Dysplasia DisGeNET Curated 1.719E-4 1.547E-3 9.606E-3 4.795E-2 2 20
32 C0588008 Severe depression DisGeNET Curated 2.087E-4 1.765E-3 1.096E-2
5.823E-2
 2 22
33 C1832916 Timothy syndrome DisGeNET Curated 2.087E-4 1.765E-3 1.096E-2
5.823E-2
 2 22
34 C1861821 CATARACT, MARNER TYPE DisGeNET Curated 2.285E-4 1.821E-3 1.131E-2
6.374E-2
 2 23
35 C1631597 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) DisGeNET Curated 2.285E-4 1.821E-3 1.131E-2
6.374E-2
 2 23
36 C0694539 Chronic atrial fibrillation DisGeNET BeFree 2.491E-4 1.930E-3 1.199E-2
6.949E-2
 2 24
37 C0014556 Epilepsy, Temporal Lobe DisGeNET Curated 2.738E-4 2.064E-3 1.282E-2
7.638E-2
 3 132
38 C0152101 Hypoplastic Left Heart Syndrome DisGeNET Curated 3.654E-4 2.614E-3 1.623E-2
1.019E-1
 2 29
39 C0041228 African Trypanosomiasis DisGeNET BeFree 3.654E-4 2.614E-3 1.623E-2
1.019E-1
 2 29
40 C0085435 Arthritis, Reactive DisGeNET BeFree 4.740E-4 3.306E-3 2.053E-2
1.323E-1
 2 33
41 C0014547 Epilepsies, Partial DisGeNET Curated 6.293E-4 4.283E-3 2.660E-2
1.756E-1
 2 38
42 C0949658 Cardiomyopathy, Hypertrophic, Familial DisGeNET Curated 6.975E-4 4.506E-3 2.798E-2
1.946E-1
 2 40
43 C0751690 Malignant Peripheral Nerve Sheath Tumor DisGeNET Curated 7.007E-4 4.506E-3 2.798E-2
1.955E-1
 3 182
44 C0042514 Tachycardia, Ventricular DisGeNET Curated 7.328E-4 4.506E-3 2.798E-2
2.045E-1
 2 41
45 C0023283 Leishmaniasis, Cutaneous DisGeNET Curated 8.440E-4 4.506E-3 2.798E-2
2.355E-1
 2 44
46 C0011206 Delirium DisGeNET Curated 8.440E-4 4.506E-3 2.798E-2
2.355E-1
 2 44
47 C0012833 Dizziness DisGeNET Curated 8.827E-4 4.506E-3 2.798E-2
2.463E-1
 2 45
48 C0018790 Cardiac Arrest DisGeNET Curated 9.079E-4 4.506E-3 2.798E-2
2.533E-1
 3 199
49 C0042571 Vertigo DisGeNET Curated 9.223E-4 4.506E-3 2.798E-2
2.573E-1
 2 46
50 C1845343 Epilepsy, X-Linked, with Variable Learning Disabilities and Behavior Disorders DisGeNET Curated 9.873E-4 4.506E-3 2.798E-2
2.755E-1
 1 1
Show 45 more annotations