Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc365_9, positive side

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1: GO: Molecular Function [Display Chart] 9 input genes in category / 144 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 4.325E-6 6.228E-4 3.457E-3 6.228E-4 4 259
2 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 1.538E-5 8.057E-4 4.472E-3 2.215E-3 4 357
3 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 1.679E-5 8.057E-4 4.472E-3 2.417E-3 4 365
4 GO:0071837 HMG box domain binding 5.204E-5 1.873E-3 1.040E-2 7.494E-3 2 23
5 GO:0051265 diolein transacylation activity 4.823E-4 7.717E-3 4.283E-2
6.945E-2
 1 1
6 GO:0036131 prostaglandin D2 11-ketoreductase activity 4.823E-4 7.717E-3 4.283E-2
6.945E-2
 1 1
7 GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity 4.823E-4 7.717E-3 4.283E-2
6.945E-2
 1 1
8 GO:0051264 mono-olein transacylation activity 4.823E-4 7.717E-3 4.283E-2
6.945E-2
 1 1
9 GO:0036130 prostaglandin H2 endoperoxidase reductase activity 4.823E-4 7.717E-3 4.283E-2
6.945E-2
 1 1
10 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 6.374E-4 8.679E-3 4.817E-2
9.179E-2
 3 379
11 GO:0000987 proximal promoter sequence-specific DNA binding 7.350E-4 8.679E-3 4.817E-2
1.058E-1
 3 398
12 GO:0001158 enhancer sequence-specific DNA binding 8.646E-4 8.679E-3 4.817E-2
1.245E-1
 2 93
13 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity 9.644E-4 8.679E-3 4.817E-2
1.389E-1
 1 2
14 GO:0047017 prostaglandin-F synthase activity 9.644E-4 8.679E-3 4.817E-2
1.389E-1
 1 2
15 GO:0070974 POU domain binding 9.644E-4 8.679E-3 4.817E-2
1.389E-1
 1 2
16 GO:0045550 geranylgeranyl reductase activity 9.644E-4 8.679E-3 4.817E-2
1.389E-1
 1 2
17 GO:0035326 enhancer binding 1.121E-3 9.496E-3
5.271E-2
1.614E-1
 2 106
18 GO:0047086 ketosteroid monooxygenase activity 1.446E-3 1.096E-2
6.084E-2
2.083E-1
 1 3
19 GO:0047718 indanol dehydrogenase activity 1.446E-3 1.096E-2
6.084E-2
2.083E-1
 1 3
20 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity 1.928E-3 1.207E-2
6.700E-2
2.776E-1
 1 4
21 GO:0047023 androsterone dehydrogenase activity 1.928E-3 1.207E-2
6.700E-2
2.776E-1
 1 4
22 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity 1.928E-3 1.207E-2
6.700E-2
2.776E-1
 1 4
23 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity 1.928E-3 1.207E-2
6.700E-2
2.776E-1
 1 4
24 GO:0035671 enone reductase activity 2.409E-3 1.308E-2
7.259E-2
3.470E-1
 1 5
25 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 3.256E-3 1.308E-2
7.259E-2
4.688E-1
 2 182
26 GO:0047035 testosterone dehydrogenase (NAD+) activity 3.372E-3 1.308E-2
7.259E-2
4.855E-1
 1 7
27 GO:0019237 centromeric DNA binding 3.372E-3 1.308E-2
7.259E-2
4.855E-1
 1 7
28 GO:0003696 satellite DNA binding 3.372E-3 1.308E-2
7.259E-2
4.855E-1
 1 7
29 GO:0004465 lipoprotein lipase activity 3.853E-3 1.308E-2
7.259E-2
5.548E-1
 1 8
30 GO:0001758 retinal dehydrogenase activity 3.853E-3 1.308E-2
7.259E-2
5.548E-1
 1 8
31 GO:0052650 NADP-retinol dehydrogenase activity 4.333E-3 1.308E-2
7.259E-2
6.240E-1
 1 9
32 GO:0034918 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
33 GO:0018450 myrtenol dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
34 GO:0034821 citronellol dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
35 GO:0034868 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
36 GO:0034582 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
37 GO:0034847 naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
38 GO:0034817 cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
39 GO:0045703 ketoreductase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
40 GO:0018448 hydroxymethylmethylsilanediol oxidase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
41 GO:0018449 1-phenylethanol dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
42 GO:0018447 chloral hydrate dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
43 GO:0034778 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
44 GO:0034863 2,4,4-trimethyl-1-pentanol dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
45 GO:0034944 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
46 GO:0034901 endosulfan hydroxyether dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
47 GO:0034891 endosulfan diol dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
48 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
49 GO:0034522 cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
50 GO:0018636 phenanthrene 9,10-monooxygenase activity 4.814E-3 1.308E-2
7.259E-2
6.932E-1
 1 10
Show 45 more annotations

2: GO: Biological Process [Display Chart] 8 input genes in category / 471 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031128 developmental induction 1.187E-4 1.817E-2
1.223E-1
5.591E-2
 2 39
2 GO:0050885 neuromuscular process controlling balance 3.314E-4 1.817E-2
1.223E-1
1.561E-1
 2 65
3 GO:1900053 negative regulation of retinoic acid biosynthetic process 4.296E-4 1.817E-2
1.223E-1
2.023E-1
 1 1
4 GO:1900052 regulation of retinoic acid biosynthetic process 4.296E-4 1.817E-2
1.223E-1
2.023E-1
 1 1
5 GO:0051355 proprioception involved in equilibrioception 4.296E-4 1.817E-2
1.223E-1
2.023E-1
 1 1
6 GO:2001207 regulation of transcription elongation from RNA polymerase I promoter 4.296E-4 1.817E-2
1.223E-1
2.023E-1
 1 1
7 GO:0008208 C21-steroid hormone catabolic process 4.296E-4 1.817E-2
1.223E-1
2.023E-1
 1 1
8 GO:0006709 progesterone catabolic process 4.296E-4 1.817E-2
1.223E-1
2.023E-1
 1 1
9 GO:0045827 negative regulation of isoprenoid metabolic process 4.296E-4 1.817E-2
1.223E-1
2.023E-1
 1 1
10 GO:0036153 triglyceride acyl-chain remodeling 4.296E-4 1.817E-2
1.223E-1
2.023E-1
 1 1
11 GO:2001208 negative regulation of transcription elongation by RNA polymerase I 4.296E-4 1.817E-2
1.223E-1
2.023E-1
 1 1
12 GO:0034504 protein localization to nucleus 4.755E-4 1.817E-2
1.223E-1
2.240E-1
 3 391
13 GO:0007422 peripheral nervous system development 5.018E-4 1.817E-2
1.223E-1
2.363E-1
 2 80
14 GO:0021536 diencephalon development 5.400E-4 1.817E-2
1.223E-1
2.544E-1
 2 83
15 GO:0001708 cell fate specification 6.206E-4 1.827E-2
1.230E-1
2.923E-1
 2 89
16 GO:0051897 positive regulation of protein kinase B signaling 6.206E-4 1.827E-2
1.230E-1
2.923E-1
 2 89
17 GO:0007409 axonogenesis 8.392E-4 1.839E-2
1.238E-1
3.953E-1
 3 475
18 GO:0021985 neurohypophysis development 8.590E-4 1.839E-2
1.238E-1
4.046E-1
 1 2
19 GO:0016488 farnesol catabolic process 8.590E-4 1.839E-2
1.238E-1
4.046E-1
 1 2
20 GO:0016487 farnesol metabolic process 8.590E-4 1.839E-2
1.238E-1
4.046E-1
 1 2
21 GO:0032298 positive regulation of DNA-dependent DNA replication initiation 8.590E-4 1.839E-2
1.238E-1
4.046E-1
 1 2
22 GO:0016107 sesquiterpenoid catabolic process 8.590E-4 1.839E-2
1.238E-1
4.046E-1
 1 2
23 GO:0050905 neuromuscular process 1.124E-3 1.881E-2
1.267E-1
5.294E-1
 2 120
24 GO:2000224 regulation of testosterone biosynthetic process 1.288E-3 1.881E-2
1.267E-1
6.068E-1
 1 3
25 GO:0003130 BMP signaling pathway involved in heart induction 1.288E-3 1.881E-2
1.267E-1
6.068E-1
 1 3
26 GO:0003133 endodermal-mesodermal cell signaling 1.288E-3 1.881E-2
1.267E-1
6.068E-1
 1 3
27 GO:0021538 epithalamus development 1.288E-3 1.881E-2
1.267E-1
6.068E-1
 1 3
28 GO:0006714 sesquiterpenoid metabolic process 1.288E-3 1.881E-2
1.267E-1
6.068E-1
 1 3
29 GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway 1.288E-3 1.881E-2
1.267E-1
6.068E-1
 1 3
30 GO:0016095 polyprenol catabolic process 1.288E-3 1.881E-2
1.267E-1
6.068E-1
 1 3
31 GO:0003134 endodermal-mesodermal cell signaling involved in heart induction 1.288E-3 1.881E-2
1.267E-1
6.068E-1
 1 3
32 GO:0021986 habenula development 1.288E-3 1.881E-2
1.267E-1
6.068E-1
 1 3
33 GO:0051896 regulation of protein kinase B signaling 1.419E-3 1.881E-2
1.267E-1
6.685E-1
 2 135
34 GO:0007498 mesoderm development 1.504E-3 1.881E-2
1.267E-1
7.083E-1
 2 139
35 GO:0060913 cardiac cell fate determination 1.717E-3 1.881E-2
1.267E-1
8.089E-1
 1 4
36 GO:0019747 regulation of isoprenoid metabolic process 1.717E-3 1.881E-2
1.267E-1
8.089E-1
 1 4
37 GO:0048880 sensory system development 1.717E-3 1.881E-2
1.267E-1
8.089E-1
 1 4
38 GO:0009753 response to jasmonic acid 1.717E-3 1.881E-2
1.267E-1
8.089E-1
 1 4
39 GO:0001712 ectodermal cell fate commitment 1.717E-3 1.881E-2
1.267E-1
8.089E-1
 1 4
40 GO:0071395 cellular response to jasmonic acid stimulus 1.717E-3 1.881E-2
1.267E-1
8.089E-1
 1 4
41 GO:0003223 ventricular compact myocardium morphogenesis 1.717E-3 1.881E-2
1.267E-1
8.089E-1
 1 4
42 GO:0019230 proprioception 1.717E-3 1.881E-2
1.267E-1
8.089E-1
 1 4
43 GO:0100012 regulation of heart induction by canonical Wnt signaling pathway 1.717E-3 1.881E-2
1.267E-1
8.089E-1
 1 4
44 GO:0043491 protein kinase B signaling 2.010E-3 2.021E-2
1.361E-1
9.467E-1
 2 161
45 GO:0045168 cell-cell signaling involved in cell fate commitment 2.146E-3 2.021E-2
1.361E-1
1.000E0
 1 5
46 GO:0071799 cellular response to prostaglandin D stimulus 2.146E-3 2.021E-2
1.361E-1
1.000E0
 1 5
47 GO:0071798 response to prostaglandin D 2.146E-3 2.021E-2
1.361E-1
1.000E0
 1 5
48 GO:0090381 regulation of heart induction 2.146E-3 2.021E-2
1.361E-1
1.000E0
 1 5
49 GO:0009786 regulation of asymmetric cell division 2.146E-3 2.021E-2
1.361E-1
1.000E0
 1 5
50 GO:1901796 regulation of signal transduction by p53 class mediator 2.160E-3 2.021E-2
1.361E-1
1.000E0
 2 167
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 9 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005667 transcription factor complex 5.499E-4 4.949E-3 1.400E-2 4.949E-3 3 368
2 GO:0000790 nuclear chromatin 9.583E-3 4.312E-2
1.220E-1
8.624E-2
 2 324

4: Human Phenotype [Display Chart] 1 input genes in category / 14 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0002540 Inability to walk 1.360E-2 4.561E-2
1.483E-1
1.904E-1
 1 64
2 HP:0200134 Epileptic encephalopathy 1.402E-2 4.561E-2
1.483E-1
1.963E-1
 1 66
3 HP:0100716 Self-injurious behavior 1.615E-2 4.561E-2
1.483E-1
2.260E-1
 1 76
4 HP:0002355 Difficulty walking 1.636E-2 4.561E-2
1.483E-1
2.290E-1
 1 77
5 HP:0001344 Absent speech 1.870E-2 4.561E-2
1.483E-1
2.617E-1
 1 88
6 HP:0002116 Deficiency of speech development 1.955E-2 4.561E-2
1.483E-1
2.736E-1
 1 92
Show 1 more annotation

5: Mouse Phenotype [Display Chart] 9 input genes in category / 297 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002292 abnormal gestational length 6.078E-5 1.445E-2
9.066E-2
 1.805E-2 2 14
2 MP:0000830 abnormal diencephalon morphology 9.733E-5 1.445E-2
9.066E-2
 2.891E-2 4 318
3 MP:0002907 abnormal parturition 2.885E-4 2.856E-2
1.791E-1
8.567E-2
 2 30
4 MP:0000837 abnormal hypothalamus morphology 5.149E-4 3.823E-2
2.398E-1
1.529E-1
 2 40

6: Domain [Display Chart] 9 input genes in category / 54 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00352 POU SMART 2.857E-14 2.572E-13 1.177E-12 1.543E-12 5 16
2 IPR000327 POU dom InterPro 2.857E-14 2.572E-13 1.177E-12 1.543E-12 5 16
3 PS00465 POU 2 PROSITE 2.857E-14 2.572E-13 1.177E-12 1.543E-12 5 16
4 PF00157 Pou Pfam 2.857E-14 2.572E-13 1.177E-12 1.543E-12 5 16
5 PS51179 POU 3 PROSITE 2.857E-14 2.572E-13 1.177E-12 1.543E-12 5 16
6 PS00035 POU 1 PROSITE 2.857E-14 2.572E-13 1.177E-12 1.543E-12 5 16
7 IPR013847 POU InterPro 4.047E-14 3.122E-13 1.428E-12 2.185E-12 5 17
8 1.10.260.40 - Gene3D 5.270E-13 3.558E-12 1.628E-11 2.846E-11 5 27
9 IPR010982 Lambda DNA-bd dom InterPro 7.750E-13 4.650E-12 2.128E-11 4.185E-11 5 29
10 1.10.10.60 - Gene3D 9.112E-10 4.921E-9 2.251E-8 4.921E-8 6 283
11 IPR009057 Homeodomain-like InterPro 2.378E-9 1.167E-8 5.341E-8 1.284E-7 6 332
12 IPR017970 Homeobox CS InterPro 1.115E-8 5.018E-8 2.296E-7 6.022E-7 5 186
13 PF00046 Homeobox Pfam 3.523E-8 1.244E-7 5.692E-7 1.903E-6 5 234
14 PS00027 HOMEOBOX 1 PROSITE 3.676E-8 1.244E-7 5.692E-7 1.985E-6 5 236
15 SM00389 HOX SMART 3.755E-8 1.244E-7 5.692E-7 2.028E-6 5 237
16 PS50071 HOMEOBOX 2 PROSITE 3.916E-8 1.244E-7 5.692E-7 2.115E-6 5 239
17 IPR001356 Homeobox dom InterPro 3.916E-8 1.244E-7 5.692E-7 2.115E-6 5 239
18 IPR033062 CENP-B InterPro 4.804E-4 1.365E-3 6.247E-3 2.594E-2 1 1
19 IPR026811 CIZ1 InterPro 4.804E-4 1.365E-3 6.247E-3 2.594E-2 1 1
20 PF09026 CENP-B dimeris Pfam 9.606E-4 2.470E-3 1.130E-2
5.187E-2
 1 2
21 IPR015115 Centromere CenpB dimerisation InterPro 9.606E-4 2.470E-3 1.130E-2
5.187E-2
 1 2
22 IPR015585 POU dom 5 InterPro 1.441E-3 3.382E-3 1.547E-2
7.779E-2
 1 3
23 IPR000972 TF octamer InterPro 1.441E-3 3.382E-3 1.547E-2
7.779E-2
 1 3
24 IPR016362 TF POU 3 InterPro 1.920E-3 4.321E-3 1.977E-2
1.037E-1
 1 4
25 IPR033562 PLPL InterPro 2.400E-3 5.184E-3 2.372E-2
1.296E-1
 1 5
26 PF01734 Patatin Pfam 4.316E-3 7.615E-3 3.484E-2
2.331E-1
 1 9
27 IPR002641 Patatin/PLipase A2-rel InterPro 4.316E-3 7.615E-3 3.484E-2
2.331E-1
 1 9
28 PS51635 PNPLA PROSITE 4.316E-3 7.615E-3 3.484E-2
2.331E-1
 1 9
29 IPR020471 Aldo/keto reductase InterPro 4.795E-3 7.615E-3 3.484E-2
2.589E-1
 1 10
30 PS00063 ALDOKETO REDUCTASE 3 PROSITE 4.795E-3 7.615E-3 3.484E-2
2.589E-1
 1 10
31 PF04218 CENP-B N Pfam 4.795E-3 7.615E-3 3.484E-2
2.589E-1
 1 10
32 PS00798 ALDOKETO REDUCTASE 1 PROSITE 4.795E-3 7.615E-3 3.484E-2
2.589E-1
 1 10
33 IPR018170 Aldo/ket reductase CS InterPro 4.795E-3 7.615E-3 3.484E-2
2.589E-1
 1 10
34 PS00062 ALDOKETO REDUCTASE 2 PROSITE 4.795E-3 7.615E-3 3.484E-2
2.589E-1
 1 10
35 IPR007889 HTH Psq InterPro 5.751E-3 7.764E-3 3.552E-2
3.106E-1
 1 12
36 IPR004875 DDE SF endonuclease dom InterPro 5.751E-3 7.764E-3 3.552E-2
3.106E-1
 1 12
37 SM00674 CENPB SMART 5.751E-3 7.764E-3 3.552E-2
3.106E-1
 1 12
38 PF03184 DDE 1 Pfam 5.751E-3 7.764E-3 3.552E-2
3.106E-1
 1 12
39 PS50960 HTH PSQ PROSITE 5.751E-3 7.764E-3 3.552E-2
3.106E-1
 1 12
40 IPR000690 Znf C2H2 matrin InterPro 5.751E-3 7.764E-3 3.552E-2
3.106E-1
 1 12
41 PF03221 HTH Tnp Tc5 Pfam 6.229E-3 7.822E-3 3.579E-2
3.364E-1
 1 13
42 PS51253 HTH CENPB PROSITE 6.229E-3 7.822E-3 3.579E-2
3.364E-1
 1 13
43 IPR006600 HTH CenpB DNA-bd dom InterPro 6.229E-3 7.822E-3 3.579E-2
3.364E-1
 1 13
44 3.20.20.100 - Gene3D 7.662E-3 8.969E-3 4.104E-2
4.137E-1
 1 16
45 IPR016035 Acyl Trfase/lysoPLipase InterPro 8.139E-3 8.969E-3 4.104E-2
4.395E-1
 1 17
46 IPR011051 RmlC Cupin InterPro 8.139E-3 8.969E-3 4.104E-2
4.395E-1
 1 17
47 IPR001395 Aldo/ket red/Kv-b InterPro 8.139E-3 8.969E-3 4.104E-2
4.395E-1
 1 17
48 PF00248 Aldo ket red Pfam 8.139E-3 8.969E-3 4.104E-2
4.395E-1
 1 17
49 IPR023210 NADP OxRdtase dom InterPro 8.139E-3 8.969E-3 4.104E-2
4.395E-1
 1 17
50 PS50171 ZF MATRIN PROSITE 8.616E-3 9.305E-3 4.257E-2
4.652E-1
 1 18
Show 45 more annotations

7: Pathway [Display Chart] 7 input genes in category / 68 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1383081 Regulation of TP53 Activity through Association with Co-factors BioSystems: REACTOME 2.458E-5 1.671E-3 8.030E-3 1.671E-3 2 14
2 1270348 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation BioSystems: REACTOME 1.686E-3 1.407E-2
6.757E-2
1.146E-1
 1 3
3 137939 Direct p53 effectors BioSystems: Pathway Interaction Database 2.263E-3 1.407E-2
6.757E-2
1.539E-1
 2 132
4 545302 androgen biosynthesis BioSystems: BIOCYC 2.809E-3 1.407E-2
6.757E-2
1.910E-1
 1 5
5 1108771 allopregnanolone biosynthesis BioSystems: BIOCYC 3.369E-3 1.407E-2
6.757E-2
2.291E-1
 1 6
6 1383076 Regulation of TP53 Activity BioSystems: REACTOME 3.385E-3 1.407E-2
6.757E-2
2.302E-1
 2 162
7 SMP00113 Oxaprozin Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
8 SMP00289 Diflunisal Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
9 SMP00086 Ibuprofen Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
10 SMP00077 Piroxicam Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
11 SMP00109 Mefanamic acid Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
12 SMP00101 Suprofen Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
13 SMP00098 Ketorolac Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
14 SMP00114 Nabumetone Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
15 SMP00104 Indomethacin Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
16 SMP00094 Sulindac Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
17 SMP00093 Diclofenac Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
18 SMP00085 Ketoprofen Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
19 SMP00120 Naproxen Pathway SMPDB 3.930E-3 1.407E-2
6.757E-2
2.672E-1
 1 7
20 SMP00102 Bromfenac Pathway SMPDB 4.490E-3 1.527E-2
7.335E-2
3.053E-1
 1 8
21 1270056 Acyl chain remodeling of DAG and TAG BioSystems: REACTOME 5.050E-3 1.635E-2
7.857E-2
3.434E-1
 1 9
22 413388 Acylglycerol degradation BioSystems: KEGG 6.170E-3 1.907E-2
9.162E-2
4.195E-1
 1 11
23 907943 superpathway of steroid hormone biosynthesis BioSystems: BIOCYC 6.729E-3 1.989E-2
9.558E-2
4.576E-1
 1 12
24 1270347 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation BioSystems: REACTOME 7.288E-3 2.065E-2
9.920E-2
4.956E-1
 1 13
25 1270043 Synthesis of bile acids and bile salts via 24-hydroxycholesterol BioSystems: REACTOME 7.847E-3 2.117E-2
1.017E-1
5.336E-1
 1 14
26 1270044 Synthesis of bile acids and bile salts via 27-hydroxycholesterol BioSystems: REACTOME 8.405E-3 2.117E-2
1.017E-1
5.716E-1
 1 15
27 1270088 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) BioSystems: REACTOME 8.405E-3 2.117E-2
1.017E-1
5.716E-1
 1 15
28 SMP00083 Acetylsalicylic Acid Pathway SMPDB 9.521E-3 2.239E-2
1.075E-1
6.475E-1
 1 17
29 SMP00084 Etodolac Pathway SMPDB 1.119E-2 2.239E-2
1.075E-1
7.612E-1
 1 20
30 SMP00116 Valdecoxib Pathway SMPDB 1.119E-2 2.239E-2
1.075E-1
7.612E-1
 1 20
31 SMP00096 Celecoxib Pathway SMPDB 1.119E-2 2.239E-2
1.075E-1
7.612E-1
 1 20
32 SMP00087 Rofecoxib Pathway SMPDB 1.119E-2 2.239E-2
1.075E-1
7.612E-1
 1 20
33 SMP00075 Arachidonic Acid Metabolism SMPDB 1.119E-2 2.239E-2
1.075E-1
7.612E-1
 1 20
34 SMP00106 Meloxicam Pathway SMPDB 1.119E-2 2.239E-2
1.075E-1
7.612E-1
 1 20
35 1269631 RA biosynthesis pathway BioSystems: REACTOME 1.286E-2 2.499E-2
1.201E-1
8.747E-1
 1 23
36 1270042 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol BioSystems: REACTOME 1.342E-2 2.535E-2
1.218E-1
9.125E-1
 1 24
37 137941 Calcium signaling in the CD4+ TCR pathway BioSystems: Pathway Interaction Database 1.564E-2 2.875E-2
1.381E-1
1.000E0
 1 28
38 1269669 RNA Polymerase III Transcription Initiation From Type 3 Promoter BioSystems: REACTOME 1.620E-2 2.898E-2
1.392E-1
1.000E0
 1 29
39 1269654 Transcriptional Regulation by TP53 BioSystems: REACTOME 1.710E-2 2.982E-2
1.432E-1
1.000E0
 2 374
40 1270041 Synthesis of bile acids and bile salts BioSystems: REACTOME 1.897E-2 3.145E-2
1.511E-1
1.000E0
 1 34
41 137956 HIF-2-alpha transcription factor network BioSystems: Pathway Interaction Database 1.897E-2 3.145E-2
1.511E-1
1.000E0
 1 34
42 1270346 Transcriptional regulation of pluripotent stem cells BioSystems: REACTOME 2.007E-2 3.187E-2
1.531E-1
1.000E0
 1 36
43 1269666 RNA Polymerase III Transcription Initiation BioSystems: REACTOME 2.062E-2 3.187E-2
1.531E-1
1.000E0
 1 37
44 137935 FOXM1 transcription factor network BioSystems: Pathway Interaction Database 2.062E-2 3.187E-2
1.531E-1
1.000E0
 1 37
45 1269665 RNA Polymerase III Abortive And Retractive Initiation BioSystems: REACTOME 2.338E-2 3.321E-2
1.596E-1
1.000E0
 1 42
46 1269664 RNA Polymerase III Transcription BioSystems: REACTOME 2.338E-2 3.321E-2
1.596E-1
1.000E0
 1 42
47 1270040 Bile acid and bile salt metabolism BioSystems: REACTOME 2.393E-2 3.321E-2
1.596E-1
1.000E0
 1 43
48 137979 FOXA1 transcription factor network BioSystems: Pathway Interaction Database 2.393E-2 3.321E-2
1.596E-1
1.000E0
 1 43
49 1269630 Signaling by Retinoic Acid BioSystems: REACTOME 2.393E-2 3.321E-2
1.596E-1
1.000E0
 1 43
50 1269624 Retinoid metabolism and transport BioSystems: REACTOME 2.448E-2 3.330E-2
1.600E-1
1.000E0
 1 44
Show 45 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 2746 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10199551 POU family transcription factors in the nervous system. Pubmed 9.047E-12 2.484E-8 2.111E-7 2.484E-8 3 3
2 1967980 A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Pubmed 3.618E-11 4.968E-8 4.221E-7 9.936E-8 3 4
3 2739723 Expression of a large family of POU-domain regulatory genes in mammalian brain development. Pubmed 9.045E-11 8.279E-8 7.033E-7 2.484E-7 3 5
4 19147497 Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development. Pubmed 1.809E-10 1.242E-7 1.055E-6 4.967E-7 3 6
5 8276396 Chromosomal organization of mammalian POU domain factors. Pubmed 7.594E-10 4.171E-7 3.543E-6 2.085E-6 3 9
6 10414983 Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
7 8537352 Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
8 8662774 A single amino acid change converts an inhibitory transcription factor into an activator. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
9 7904822 Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
10 8995448 Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
11 8960364 Expression of Oct-4 during differentiation of murine F9 cells. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
12 19323995 Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
13 24608965 Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
14 17668438 Brn3 transcription factors control terminal osteoclastogenesis. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
15 9582431 NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
16 19171782 A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
17 1690859 New type of POU domain in germ line-specific protein Oct-4. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
18 24736625 Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
19 7969117 Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
20 8234287 Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. Pubmed 4.936E-8 6.777E-6 5.757E-5 1.355E-4 2 2
21 24116103 Genetic interactions between Brn3 transcription factors in retinal ganglion cell type specification. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
22 23437007 SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
23 17145718 Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
24 7623109 The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
25 7945330 The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
26 15094508 Doppel expression is regulated by the Brn-3a and Brn-3b transcription factors. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
27 8162704 Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
28 20826176 Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: analysis of wild type and mutant cells using genetically-directed sparse labeling. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
29 9448000 POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
30 8290353 Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
31 21935940 Differential expression of Brn3 transcription factors in intrinsically photosensitive retinal ganglion cells in mouse. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
32 12782656 The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
33 17273778 Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
34 9598366 Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
35 7935408 The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain. Pubmed 1.481E-7 1.162E-5 9.869E-5 4.066E-4 2 3
36 19924248 New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling. Pubmed 2.961E-7 2.033E-5 1.727E-4 8.131E-4 2 4
37 9256502 Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Pubmed 2.961E-7 2.033E-5 1.727E-4 8.131E-4 2 4
38 1970171 Cloning and sequencing of POU-boxes expressed in mouse testis. Pubmed 2.961E-7 2.033E-5 1.727E-4 8.131E-4 2 4
39 9368058 The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors. Pubmed 2.961E-7 2.033E-5 1.727E-4 8.131E-4 2 4
40 11550273 Specific localization of transcription factors in the chromatin of mouse mature spermatozoa. Pubmed 2.961E-7 2.033E-5 1.727E-4 8.131E-4 2 4
41 20533399 Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion. Pubmed 4.934E-7 2.657E-5 2.257E-4 1.355E-3 2 5
42 8637595 Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Pubmed 4.934E-7 2.657E-5 2.257E-4 1.355E-3 2 5
43 18368538 Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression. Pubmed 4.934E-7 2.657E-5 2.257E-4 1.355E-3 2 5
44 23720416 Characterization of enhancers active in the mouse embryonic cerebral cortex suggests Sox/Pou cis-regulatory logics and heterogeneity of cortical progenitors. Pubmed 4.934E-7 2.657E-5 2.257E-4 1.355E-3 2 5
45 22262898 Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis. Pubmed 4.934E-7 2.657E-5 2.257E-4 1.355E-3 2 5
46 9630743 Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Pubmed 4.934E-7 2.657E-5 2.257E-4 1.355E-3 2 5
47 15262984 Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells. Pubmed 4.934E-7 2.657E-5 2.257E-4 1.355E-3 2 5
48 12923055 Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Pubmed 4.934E-7 2.657E-5 2.257E-4 1.355E-3 2 5
49 28594399 Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart. Pubmed 4.934E-7 2.657E-5 2.257E-4 1.355E-3 2 5
50 8900043 POU homeodomain genes and myogenesis. Pubmed 4.934E-7 2.657E-5 2.257E-4 1.355E-3 2 5
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 712 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:TBP TBP interactions 9.151E-5 4.550E-2
3.251E-1
6.515E-2
 3 186
2 int:SOX10 SOX10 interactions 1.278E-4 4.550E-2
3.251E-1
9.100E-2
 2 34

10: Cytoband [Display Chart] 9 input genes in category / 9 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 4q31.2 4q31.2 2.597E-4 2.337E-3 6.611E-3 2.337E-3 1 1
2 6q16 6q16 1.298E-3 4.671E-3 1.321E-2 1.168E-2 1 5
3 10p15-p14 10p15-p14 1.557E-3 4.671E-3 1.321E-2 1.401E-2 1 6
4 9q34.1 9q34.1 4.923E-3 1.026E-2 2.902E-2 4.431E-2 1 19
5 13q31.1 13q31.1 5.699E-3 1.026E-2 2.902E-2
5.129E-2
 1 22
6 1q24.2 1q24.2 8.022E-3 1.203E-2 3.404E-2
7.219E-2
 1 31
7 6p21.31 6p21.31 1.060E-2 1.362E-2 3.854E-2
9.537E-2
 1 41
8 22q13.31 22q13.31 1.342E-2 1.510E-2 4.272E-2
1.208E-1
 1 52
9 20p13 20p13 2.618E-2 2.618E-2
7.406E-2
2.356E-1
 1 102
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 162 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$HP1SITEFACTOR Q6 V$HP1SITEFACTOR Q6 2.355E-4 1.999E-2
1.133E-1
 3.815E-2 3 189
2 V$AREB6 03 V$AREB6 03 2.467E-4 1.999E-2
1.133E-1
 3.997E-2 3 192
3 TGATTTRY V$GFI1 01 TGATTTRY V$GFI1 01 5.000E-4 2.700E-2
1.530E-1
8.099E-2
 3 244

12: Gene Family [Display Chart] 8 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 523 POU class homeoboxes and pseudogenes genenames.org 1.132E-13 5.660E-13 1.292E-12 5.660E-13 5 23
2 466 Patatin like phospholipase domain containing genenames.org 4.389E-3 8.222E-3 1.877E-2 2.195E-2 1 10
3 533 Helix-turn-helix CENPB type domain containing genenames.org 5.703E-3 8.222E-3 1.877E-2 2.851E-2 1 13
4 399 Aldo-keto reductases genenames.org 6.578E-3 8.222E-3 1.877E-2 3.289E-2 1 15
5 464 Lipases genenames.org 9.635E-3 9.635E-3 2.200E-2 4.817E-2 1 22

13: Coexpression [Display Chart] 9 input genes in category / 689 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M10991 Overconnected mutated transcription factors regulating genes within the breast cancer amplicome. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.095E-5 1.694E-2
1.205E-1
 2.132E-2 2 22
2 M5194 Genes down-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to L. major. MSigDB C7: Immunologic Signatures (v6.0) 4.918E-5 1.694E-2
1.205E-1
 3.388E-2 3 197
3 M4339 Genes down-regulated in SCLC (small cell lung cancer) cells with acquired resistance to ABT-737 [PubChem=11228183], an inhibitor of the BCL2 [GeneID=596] family proteins. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.503E-4 3.452E-2
2.456E-1
1.036E-1
 2 48
4 16254190-Table2 Mouse Skin Zhang05 74genes GeneSigDB 3.023E-4 4.512E-2
3.209E-1
2.083E-1
 2 68
5 M16458 Selected gradually up-regulated genes in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts). MSigDB C2: CGP Curated Gene Sets (v6.0) 3.876E-4 4.512E-2
3.209E-1
2.671E-1
 2 77
6 19074870-SuppTable4a Human StemCell Harris08 490genes GeneSigDB 3.929E-4 4.512E-2
3.209E-1
2.707E-1
 3 398
Show 1 more annotation

14: Coexpression Atlas [Display Chart] 9 input genes in category / 564 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup7 Excitatory.subGroup7 Subtype Excitatory.subGroup7 Cerebellum Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup7 Excitatory.subGroup7 Subtype Excitatory.subGroup7 Cerebellum Top 200 Genes BrainMap 4.615E-5 2.603E-2
1.800E-1
 2.603E-2 3 182

15: Computational [Display Chart] 6 input genes in category / 49 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 9 input genes in category / 508 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-6895-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.670E-5 1.819E-2
1.239E-1
 2.373E-2 2 83
2 hsa-miR-625:PITA hsa-miR-625:PITA TOP PITA 1.165E-4 1.819E-2
1.239E-1
5.918E-2
 2 131
3 hsa-miR-1275:PITA hsa-miR-1275:PITA TOP PITA 1.201E-4 1.819E-2
1.239E-1
6.100E-2
 2 133
4 hsa-miR-874:PITA hsa-miR-874:PITA TOP PITA 1.507E-4 1.819E-2
1.239E-1
7.655E-2
 2 149
5 hsa-miR-549:PITA hsa-miR-549:PITA TOP PITA 1.892E-4 1.819E-2
1.239E-1
9.612E-2
 2 167
6 hsa-miR-544a:TargetScan hsa-miR-544a TargetScan 2.149E-4 1.819E-2
1.239E-1
1.092E-1
 2 178
7 hsa-miR-7113-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.847E-4 1.833E-2
1.248E-1
1.446E-1
 2 205
8 hsa-miR-593:PITA hsa-miR-593:PITA TOP PITA 2.931E-4 1.833E-2
1.248E-1
1.489E-1
 2 208
9 TAGCTTT,MIR-9:MSigDB TAGCTTT,MIR-9:MSigDB MSigDB 3.427E-4 1.833E-2
1.248E-1
1.741E-1
 2 225
10 hsa-miR-455-3p.2:TargetScan hsa-miR-455-3p.2 TargetScan 4.159E-4 1.833E-2
1.248E-1
2.113E-1
 2 248
11 hsa-miR-936:PITA hsa-miR-936:PITA TOP PITA 4.534E-4 1.833E-2
1.248E-1
2.303E-1
 2 259
12 TGCACTG,MIR-152:MSigDB TGCACTG,MIR-152:MSigDB MSigDB 5.636E-4 1.833E-2
1.248E-1
2.863E-1
 2 289
13 TGCACTG,MIR-148B:MSigDB TGCACTG,MIR-148B:MSigDB MSigDB 5.636E-4 1.833E-2
1.248E-1
2.863E-1
 2 289
14 TGCACTG,MIR-148A:MSigDB TGCACTG,MIR-148A:MSigDB MSigDB 5.636E-4 1.833E-2
1.248E-1
2.863E-1
 2 289
15 hsa-miR-4775:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.950E-4 1.833E-2
1.248E-1
3.023E-1
 2 297
16 hsa-miR-5096:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.150E-4 1.833E-2
1.248E-1
3.124E-1
 2 302
17 hsa-miR-211-5p:Functional MTI Functional MTI miRTarbase 7.510E-4 1.833E-2
1.248E-1
3.815E-1
 2 334
18 hsa-miR-324-3p:Functional MTI Functional MTI miRTarbase 7.689E-4 1.833E-2
1.248E-1
3.906E-1
 2 338
19 hsa-miR-18a-3p:Functional MTI Functional MTI miRTarbase 8.239E-4 1.833E-2
1.248E-1
4.185E-1
 2 350
20 hsa-miR-1290:PITA hsa-miR-1290:PITA TOP PITA 8.379E-4 1.833E-2
1.248E-1
4.257E-1
 2 353
21 hsa-miR-6504-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.050E-4 1.833E-2
1.248E-1
4.597E-1
 2 367
22 TTGCACT,MIR-130B:MSigDB TTGCACT,MIR-130B:MSigDB MSigDB 9.395E-4 1.833E-2
1.248E-1
4.772E-1
 2 374
23 TTGCACT,MIR-130A:MSigDB TTGCACT,MIR-130A:MSigDB MSigDB 9.395E-4 1.833E-2
1.248E-1
4.772E-1
 2 374
24 TTGCACT,MIR-301:MSigDB TTGCACT,MIR-301:MSigDB MSigDB 9.395E-4 1.833E-2
1.248E-1
4.772E-1
 2 374
25 hsa-miR-583:PITA hsa-miR-583:PITA TOP PITA 9.594E-4 1.833E-2
1.248E-1
4.874E-1
 2 378
26 hsa-miR-590-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.021E-3 1.833E-2
1.248E-1
5.185E-1
 2 390
27 hsa-miR-3193:mirSVR lowEffct hsa-miR-3193:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.036E-3 1.833E-2
1.248E-1
5.264E-1
 2 393
28 hsa-miR-103:PITA hsa-miR-103:PITA TOP PITA 1.047E-3 1.833E-2
1.248E-1
5.317E-1
 2 395
29 hsa-miR-107:PITA hsa-miR-107:PITA TOP PITA 1.047E-3 1.833E-2
1.248E-1
5.317E-1
 2 395
30 hsa-miR-105:PITA hsa-miR-105:PITA TOP PITA 1.255E-3 2.125E-2
1.447E-1
6.375E-1
 2 433
31 hsa-miR-184:mirSVR lowEffct hsa-miR-184:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 1.301E-3 2.132E-2
1.452E-1
6.610E-1
 2 441
32 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 1.557E-3 2.197E-2
1.496E-1
7.909E-1
 2 483
33 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 1.557E-3 2.197E-2
1.496E-1
7.909E-1
 2 483
34 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 1.557E-3 2.197E-2
1.496E-1
7.909E-1
 2 483
35 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 1.557E-3 2.197E-2
1.496E-1
7.909E-1
 2 483
36 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 1.557E-3 2.197E-2
1.496E-1
7.909E-1
 2 483
37 hsa-miR-1249:PITA hsa-miR-1249:PITA TOP PITA 1.867E-3 2.564E-2
1.746E-1
9.486E-1
 1 15
38 hsa-miR-4285:mirSVR highEffct hsa-miR-4285:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.613E-3 3.494E-2
2.379E-1
1.000E0
 1 21
39 hsa-miR-6880-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.738E-3 3.566E-2
2.428E-1
1.000E0
 1 22
40 hsa-miR-656-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.607E-3 4.581E-2
3.119E-1
1.000E0
 1 29
41 hsa-miR-6816-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.352E-3 4.786E-2
3.259E-1
1.000E0
 1 35
42 hsa-miR-4681:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.476E-3 4.786E-2
3.259E-1
1.000E0
 1 36
43 hsa-miR-144-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.476E-3 4.786E-2
3.259E-1
1.000E0
 1 36
44 hsa-miR-4288:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.724E-3 4.786E-2
3.259E-1
1.000E0
 1 38
45 hsa-miR-602:PITA hsa-miR-602:PITA TOP PITA 4.724E-3 4.786E-2
3.259E-1
1.000E0
 1 38
46 hsa-miR-564:PITA hsa-miR-564:PITA TOP PITA 4.724E-3 4.786E-2
3.259E-1
1.000E0
 1 38
47 hsa-miR-487a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.724E-3 4.786E-2
3.259E-1
1.000E0
 1 38
48 hsa-miR-487b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.973E-3 4.786E-2
3.259E-1
1.000E0
 1 40
49 hsa-miR-632:Functional MTI Functional MTI miRTarbase 5.097E-3 4.786E-2
3.259E-1
1.000E0
 1 41
50 hsa-miR-451:PITA hsa-miR-451:PITA TOP PITA 5.469E-3 4.786E-2
3.259E-1
1.000E0
 1 44
Show 45 more annotations

17: Drug [Display Chart] 9 input genes in category / 2114 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000011527 3-octanol Stitch 2.895E-6 2.504E-3 2.062E-2 6.121E-3 2 7
2 CID000001759 AC1L1C6C Stitch 3.049E-6 2.504E-3 2.062E-2 6.446E-3 3 77
3 CID000001629 3-(phosphonomethyl)pyridine-2-carboxylic acid Stitch 3.554E-6 2.504E-3 2.062E-2 7.513E-3 3 81
4 1884 DN Cimetidine [51481-61-9]; Down 200; 15.8uM; PC3; HG-U133A Broad Institute CMAP Down 4.881E-5 2.579E-2
2.124E-1
1.032E-1
 3 194
5 ctd:D013196 Dihydrotestosterone CTD 3.064E-4 4.070E-2
3.351E-1
6.478E-1
 3 361
6 ctd:C007702 farnesoic acid CTD 3.940E-4 4.070E-2
3.351E-1
8.330E-1
 1 1
7 DB02056 (5e,13e)-9,15-Dihydroxy-11-Oxoprosta-5,13-Dien-1-Oicacid Drug Bank 3.940E-4 4.070E-2
3.351E-1
8.330E-1
 1 1
8 CID004044373 AC1OF0K9 Stitch 3.940E-4 4.070E-2
3.351E-1
8.330E-1
 1 1
9 DB07700 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN Drug Bank 3.940E-4 4.070E-2
3.351E-1
8.330E-1
 1 1
10 ctd:C526888 N-(4-chlorobenzoyl)melatonin CTD 3.940E-4 4.070E-2
3.351E-1
8.330E-1
 1 1
11 CID000656532 glucocleomin Stitch 3.940E-4 4.070E-2
3.351E-1
8.330E-1
 1 1
12 CID006433206 sulforaphene Stitch 3.940E-4 4.070E-2
3.351E-1
8.330E-1
 1 1
13 CID000656528 glucocapparin Stitch 3.940E-4 4.070E-2
3.351E-1
8.330E-1
 1 1
14 ctd:C520534 2'-hydroxyflavanone CTD 3.940E-4 4.070E-2
3.351E-1
8.330E-1
 1 1
15 CID000014541 alpha-methylcinnamic acid Stitch 3.940E-4 4.070E-2
3.351E-1
8.330E-1
 1 1
16 DB01698 Rutin Drug Bank 3.940E-4 4.070E-2
3.351E-1
8.330E-1
 1 1
17 CID006327639 germanium monoxide Stitch 5.672E-4 4.070E-2
3.351E-1
1.000E0
 2 92
18 ctd:C016836 allopregnane-3,20-diol CTD 7.879E-4 4.070E-2
3.351E-1
1.000E0
 1 2
19 ctd:C495787 benz(a)anthracene-3,4-dione CTD 7.879E-4 4.070E-2
3.351E-1
1.000E0
 1 2
20 CID000164470 AC1L4UU4 Stitch 7.879E-4 4.070E-2
3.351E-1
1.000E0
 1 2
21 CID000026787 MC MO Stitch 7.879E-4 4.070E-2
3.351E-1
1.000E0
 1 2
22 ctd:C012764 baccharin CTD 7.879E-4 4.070E-2
3.351E-1
1.000E0
 1 2
23 ctd:C103439 oracine CTD 7.879E-4 4.070E-2
3.351E-1
1.000E0
 1 2
24 ctd:C028952 allopregnan-20 alpha-ol-3-one CTD 7.879E-4 4.070E-2
3.351E-1
1.000E0
 1 2
25 CID000146656 DC92-B Stitch 7.879E-4 4.070E-2
3.351E-1
1.000E0
 1 2
26 ctd:C510582 alpha-methylcinnamic acid CTD 7.879E-4 4.070E-2
3.351E-1
1.000E0
 1 2
27 ctd:D001960 Bromazepam CTD 7.879E-4 4.070E-2
3.351E-1
1.000E0
 1 2
28 CID000656538 glucoerucin Stitch 7.879E-4 4.070E-2
3.351E-1
1.000E0
 1 2
29 CID000437038 AC1L92W3 Stitch 1.182E-3 4.070E-2
3.351E-1
1.000E0
 1 3
30 ctd:C007201 cyclopentanone CTD 1.182E-3 4.070E-2
3.351E-1
1.000E0
 1 3
31 ctd:C016327 cyclopentanol CTD 1.182E-3 4.070E-2
3.351E-1
1.000E0
 1 3
32 ctd:C530610 dichloro(4-cymene)ruthenium(II) CTD 1.182E-3 4.070E-2
3.351E-1
1.000E0
 1 3
33 ctd:C058818 4-benzoylbenzoic acid CTD 1.182E-3 4.070E-2
3.351E-1
1.000E0
 1 3
34 DB01536 4-Androstenedione Drug Bank 1.182E-3 4.070E-2
3.351E-1
1.000E0
 1 3
35 DB00905 Bimatoprost Drug Bank 1.575E-3 4.070E-2
3.351E-1
1.000E0
 1 4
36 CID000010083 pipradrol Stitch 1.575E-3 4.070E-2
3.351E-1
1.000E0
 1 4
37 ctd:D011278 Pregnanes CTD 1.575E-3 4.070E-2
3.351E-1
1.000E0
 1 4
38 ctd:C000621860 UNC0642 CTD 1.575E-3 4.070E-2
3.351E-1
1.000E0
 1 4
39 ctd:C052610 3-hydroxypregn-4-en-20-one CTD 1.575E-3 4.070E-2
3.351E-1
1.000E0
 1 4
40 CID000131382 DBD-H Stitch 1.575E-3 4.070E-2
3.351E-1
1.000E0
 1 4
41 DB02266 Flufenamic Acid Drug Bank 1.575E-3 4.070E-2
3.351E-1
1.000E0
 1 4
42 ctd:C019106 tetralol CTD 1.575E-3 4.070E-2
3.351E-1
1.000E0
 1 4
43 ctd:C005522 cloxazolam CTD 1.575E-3 4.070E-2
3.351E-1
1.000E0
 1 4
44 ctd:C018156 3',3'',5',5''-tetrabromophenolphthalein CTD 1.575E-3 4.070E-2
3.351E-1
1.000E0
 1 4
45 ctd:C511004 SD-208 CTD 1.575E-3 4.070E-2
3.351E-1
1.000E0
 1 4
46 ctd:C010969 gliquidone CTD 1.575E-3 4.070E-2
3.351E-1
1.000E0
 1 4
47 CID000644213 GW9662 Stitch 1.763E-3 4.070E-2
3.351E-1
1.000E0
 2 163
48 CID000009395 paraoxon Stitch 1.785E-3 4.070E-2
3.351E-1
1.000E0
 2 164
49 ctd:D006914 Hydroxysteroids CTD 1.969E-3 4.070E-2
3.351E-1
1.000E0
 1 5
50 CID000453844 TBST Stitch 1.969E-3 4.070E-2
3.351E-1
1.000E0
 1 5
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 235 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0262407 cervical abnormality DisGeNET BeFree 2.742E-7 6.444E-5 3.891E-4 6.444E-5 2 2
2 20081201:Yuan Plasma levels of liver enzymes GWAS 4.666E-5 5.199E-3 3.140E-2 1.096E-2 2 19
3 C0036875 Disorders of Sex Development DisGeNET Curated 6.895E-5 5.199E-3 3.140E-2 1.620E-2 2 23
4 C0005694 Bladder neck obstruction DisGeNET Curated 8.850E-5 5.199E-3 3.140E-2 2.080E-2 2 26
5 C0206708 Cervical Intraepithelial Neoplasia DisGeNET Curated 1.774E-4 8.339E-3
5.036E-2
 4.169E-2 3 213
6 C0267925 Stenosis of bile duct DisGeNET BeFree 5.554E-4 1.631E-2
9.852E-2
1.305E-1
 1 1
7 C0233122 Uterine dysfunction DisGeNET BeFree 5.554E-4 1.631E-2
9.852E-2
1.305E-1
 1 1
8 C1334680 Mediastinal Seminoma DisGeNET BeFree 5.554E-4 1.631E-2
9.852E-2
1.305E-1
 1 1
9 C1535964 Cholestatic pruritus DisGeNET BeFree 1.110E-3 1.864E-2
1.126E-1
2.610E-1
 1 2
10 C0334518 Polyembryoma DisGeNET BeFree 1.110E-3 1.864E-2
1.126E-1
2.610E-1
 1 2
11 C0684354 Benign neoplasm of sweat gland DisGeNET BeFree 1.110E-3 1.864E-2
1.126E-1
2.610E-1
 1 2
12 C3658267 Prostatic Neoplasms, Castration-Resistant DisGeNET Curated 1.110E-3 1.864E-2
1.126E-1
2.610E-1
 1 2
13 C1865819 CERVICAL DYSTONIA, PRIMARY DisGeNET Curated 1.110E-3 1.864E-2
1.126E-1
2.610E-1
 1 2
14 C0019522 Adenoma, Sweat Gland DisGeNET BeFree 1.110E-3 1.864E-2
1.126E-1
2.610E-1
 1 2
15 C0206671 Eccrine acrospiroma DisGeNET BeFree 2.220E-3 2.981E-2
1.800E-1
5.217E-1
 1 4
16 C0027661 Neoplasms, Hormone-Dependent DisGeNET Curated 2.220E-3 2.981E-2
1.800E-1
5.217E-1
 1 4
17 C0396072 Laryngeal papillomatosis DisGeNET BeFree 2.220E-3 2.981E-2
1.800E-1
5.217E-1
 1 4
18 C0022346 Icterus DisGeNET Curated 2.284E-3 2.981E-2
1.800E-1
5.366E-1
 2 132
19 C1859062 LONG QT SYNDROME 3 DisGeNET Curated 2.774E-3 3.260E-2
1.968E-1
6.519E-1
 1 5
20 C0752197 Adult-Onset Dystonias DisGeNET BeFree 2.774E-3 3.260E-2
1.968E-1
6.519E-1
 1 5
21 C0564408 Manic mood DisGeNET Curated 3.328E-3 3.555E-2
2.147E-1
7.821E-1
 1 6
22 C0742132 cervical cancer metastasis DisGeNET BeFree 3.328E-3 3.555E-2
2.147E-1
7.821E-1
 1 6
23 C2919755 Testicular dysgenesis syndrome DisGeNET BeFree 3.882E-3 3.769E-2
2.276E-1
9.123E-1
 1 7
24 20090106:Potkin Brain imaging in schizophrenia (interaction) GWAS 4.435E-3 3.769E-2
2.276E-1
1.000E0
 1 8
25 C0153452 Malignant neoplasm of gallbladder DisGeNET BeFree 4.474E-3 3.769E-2
2.276E-1
1.000E0
 2 186
26 C0348374 Malignant neoplasm of central nervous system DisGeNET Curated 4.989E-3 3.769E-2
2.276E-1
1.000E0
 1 9
27 C0026205 Miosis disorder DisGeNET Curated 4.989E-3 3.769E-2
2.276E-1
1.000E0
 1 9
28 C3164344 Adult onset autosomal dominant leukodystrophy DisGeNET Curated 4.989E-3 3.769E-2
2.276E-1
1.000E0
 1 9
29 C0030354 Papilloma DisGeNET Curated 5.054E-3 3.769E-2
2.276E-1
1.000E0
 2 198
30 C0008370 Cholestasis DisGeNET Curated 5.154E-3 3.769E-2
2.276E-1
1.000E0
 2 200
31 C0205851 Germ cell tumor DisGeNET BeFree 5.255E-3 3.769E-2
2.276E-1
1.000E0
 2 202
32 C0085648 Synovial Cyst DisGeNET BeFree 5.255E-3 3.769E-2
2.276E-1
1.000E0
 2 202
33 C1258666 Myxoid cyst DisGeNET BeFree 5.356E-3 3.769E-2
2.276E-1
1.000E0
 2 204
34 C1857231 LACTASE PERSISTENCE DisGeNET BeFree 5.542E-3 3.769E-2
2.276E-1
1.000E0
 1 10
35 C0206659 Embryonal Carcinoma DisGeNET BeFree 5.615E-3 3.769E-2
2.276E-1
1.000E0
 2 209
36 C0220668 Congenital contractural arachnodactyly DisGeNET Curated 5.825E-3 3.769E-2
2.276E-1
1.000E0
 2 213
37 C0235782 Gallbladder Carcinoma DisGeNET BeFree 5.986E-3 3.769E-2
2.276E-1
1.000E0
 2 216
38 C0555278 Cerebral metastasis DisGeNET BeFree 6.094E-3 3.769E-2
2.276E-1
1.000E0
 1 11
39 C0334279 Adenocarcinoma, intestinal type DisGeNET BeFree 6.647E-3 4.005E-2
2.419E-1
1.000E0
 1 12
40 C0740447 Diabetic peripheral neuropathy DisGeNET BeFree 7.199E-3 4.028E-2
2.432E-1
1.000E0
 1 13
41 C0019025 Hemoglobin F Disease DisGeNET Curated 7.199E-3 4.028E-2
2.432E-1
1.000E0
 1 13
42 C0027658 Neoplasms, Germ Cell and Embryonal DisGeNET Curated 7.199E-3 4.028E-2
2.432E-1
1.000E0
 1 13
43 C2987516 Cervix Intraepithelial Neoplasia Grade 3 AJCC v7 DisGeNET BeFree 7.750E-3 4.236E-2
2.558E-1
1.000E0
 1 14
44 C0022118 Transient ischemia DisGeNET BeFree 8.302E-3 4.332E-2
2.616E-1
1.000E0
 1 15
45 C0206660 Germinoma DisGeNET BeFree 8.853E-3 4.332E-2
2.616E-1
1.000E0
 1 16
46 C0032019 Pituitary Neoplasms DisGeNET Curated 9.151E-3 4.332E-2
2.616E-1
1.000E0
 2 269
47 C0008312 Primary biliary cirrhosis DisGeNET Curated 9.349E-3 4.332E-2
2.616E-1
1.000E0
 2 272
48 C0027070 Myoepithelioma DisGeNET BeFree 9.404E-3 4.332E-2
2.616E-1
1.000E0
 1 17
49 C0013423 Dystonia Musculorum Deformans DisGeNET Curated 9.404E-3 4.332E-2
2.616E-1
1.000E0
 1 17
50 C0032584 polyps DisGeNET Curated 9.749E-3 4.332E-2
2.616E-1
1.000E0
 2 278
Show 45 more annotations