Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc367_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 56 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1.055E-7 4.914E-6 2.266E-5 5.906E-6 3 28
2 GO:0008395 steroid hydroxylase activity 1.755E-7 4.914E-6 2.266E-5 9.828E-6 3 33
3 GO:0004497 monooxygenase activity 4.694E-6 8.762E-5 4.040E-4 2.629E-4 3 97
4 GO:0020037 heme binding 1.159E-5 1.132E-4 5.220E-4 6.492E-4 3 131
5 GO:0008392 arachidonic acid epoxygenase activity 1.264E-5 1.132E-4 5.220E-4 7.076E-4 2 15
6 GO:0008391 arachidonic acid monooxygenase activity 1.264E-5 1.132E-4 5.220E-4 7.076E-4 2 15
7 GO:0046906 tetrapyrrole binding 1.415E-5 1.132E-4 5.220E-4 7.924E-4 3 140
8 GO:0005506 iron ion binding 2.151E-5 1.506E-4 6.943E-4 1.204E-3 3 161
9 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 2.760E-5 1.717E-4 7.920E-4 1.546E-3 3 175
10 GO:0015238 drug transmembrane transporter activity 3.604E-5 1.835E-4 8.460E-4 2.018E-3 2 25
11 GO:0070330 aromatase activity 3.604E-5 1.835E-4 8.460E-4 2.018E-3 2 25
12 GO:0019825 oxygen binding 1.524E-4 7.114E-4 3.281E-3 8.537E-3 2 51
13 GO:0022804 active transmembrane transporter activity 2.411E-4 1.039E-3 4.789E-3 1.350E-2 3 363
14 GO:0001616 growth hormone secretagogue receptor activity 3.751E-4 1.167E-3 5.382E-3 2.101E-2 1 1
15 GO:0047638 albendazole monooxygenase activity 3.751E-4 1.167E-3 5.382E-3 2.101E-2 1 1
16 GO:0050591 quinine 3-monooxygenase activity 3.751E-4 1.167E-3 5.382E-3 2.101E-2 1 1
17 GO:0015127 bilirubin transmembrane transporter activity 3.751E-4 1.167E-3 5.382E-3 2.101E-2 1 1
18 GO:0033780 taurochenodeoxycholate 6alpha-hydroxylase activity 3.751E-4 1.167E-3 5.382E-3 2.101E-2 1 1
19 GO:0042626 ATPase activity, coupled to transmembrane movement of substances 7.093E-4 2.090E-3 9.640E-3 3.972E-2 2 110
20 GO:0050649 testosterone 6-beta-hydroxylase activity 7.501E-4 2.100E-3 9.685E-3 4.201E-2 1 2
21 GO:0015399 primary active transmembrane transporter activity 8.293E-4 2.111E-3 9.735E-3 4.644E-2 2 119
22 GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity 8.293E-4 2.111E-3 9.735E-3 4.644E-2 2 119
23 GO:0043492 ATPase activity, coupled to movement of substances 9.144E-4 2.226E-3 1.027E-2
5.121E-2
 2 125
24 GO:0008389 coumarin 7-hydroxylase activity 1.125E-3 2.322E-3 1.071E-2
6.300E-2
 1 3
25 GO:0070576 vitamin D 24-hydroxylase activity 1.125E-3 2.322E-3 1.071E-2
6.300E-2
 1 3
26 GO:0030343 vitamin D3 25-hydroxylase activity 1.125E-3 2.322E-3 1.071E-2
6.300E-2
 1 3
27 GO:0070643 vitamin D 25-hydroxylase activity 1.125E-3 2.322E-3 1.071E-2
6.300E-2
 1 3
28 GO:0046943 carboxylic acid transmembrane transporter activity 1.161E-3 2.322E-3 1.071E-2
6.503E-2
 2 141
29 GO:0005342 organic acid transmembrane transporter activity 1.211E-3 2.338E-3 1.078E-2
6.780E-2
 2 144
30 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor 1.500E-3 2.709E-3 1.249E-2
8.398E-2
 1 4
31 GO:0034875 caffeine oxidase activity 1.500E-3 2.709E-3 1.249E-2
8.398E-2
 1 4
32 GO:0016520 growth hormone-releasing hormone receptor activity 1.874E-3 3.280E-3 1.513E-2
1.050E-1
 1 5
33 GO:0008514 organic anion transmembrane transporter activity 1.945E-3 3.300E-3 1.522E-2
1.089E-1
 2 183
34 GO:0008559 xenobiotic transmembrane transporting ATPase activity 2.623E-3 4.321E-3 1.992E-2
1.469E-1
 1 7
35 GO:0042910 xenobiotic transmembrane transporter activity 2.998E-3 4.796E-3 2.212E-2
1.679E-1
 1 8
36 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 3.746E-3 5.827E-3 2.687E-2
2.098E-1
 1 10
37 GO:0043225 ATPase-coupled anion transmembrane transporter activity 4.120E-3 6.235E-3 2.875E-2
2.307E-1
 1 11
38 GO:0008509 anion transmembrane transporter activity 5.029E-3 7.411E-3 3.418E-2
2.816E-1
 2 297
39 GO:0015125 bile acid transmembrane transporter activity 5.614E-3 8.061E-3 3.717E-2
3.144E-1
 1 15
40 GO:0042623 ATPase activity, coupled 6.247E-3 8.746E-3 4.033E-2
3.498E-1
 2 332
41 GO:0015347 sodium-independent organic anion transmembrane transporter activity 7.852E-3 1.072E-2 4.946E-2
4.397E-1
 1 21
42 GO:0016887 ATPase activity 1.105E-2 1.474E-2
6.796E-2
6.190E-1
 2 446
43 GO:0005310 dicarboxylic acid transmembrane transporter activity 1.157E-2 1.507E-2
6.950E-2
6.481E-1
 1 31
44 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1.565E-2 1.992E-2
9.186E-2
8.765E-1
 1 42
45 GO:0017046 peptide hormone binding 1.676E-2 2.085E-2
9.617E-2
9.386E-1
 1 45
46 GO:0008028 monocarboxylic acid transmembrane transporter activity 1.713E-2 2.085E-2
9.617E-2
9.593E-1
 1 46
47 GO:1901618 organic hydroxy compound transmembrane transporter activity 2.303E-2 2.744E-2
1.265E-1
1.000E0
 1 62
48 GO:0042625 ATPase coupled ion transmembrane transporter activity 2.743E-2 3.201E-2
1.476E-1
1.000E0
 1 74
49 GO:0042562 hormone binding 3.073E-2 3.512E-2
1.619E-1
1.000E0
 1 83
50 GO:0005496 steroid binding 3.801E-2 4.257E-2
1.963E-1
1.000E0
 1 103
Show 45 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 263 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042737 drug catabolic process 1.182E-8 3.108E-6 1.912E-5 3.108E-6 3 14
2 GO:0006855 drug transmembrane transport 6.560E-8 8.626E-6 5.306E-5 1.725E-5 3 24
3 GO:0015893 drug transport 1.766E-7 1.490E-5 9.163E-5 4.644E-5 3 33
4 GO:0042493 response to drug 2.266E-7 1.490E-5 9.163E-5 5.958E-5 5 481
5 GO:0017144 drug metabolic process 3.194E-7 1.592E-5 9.795E-5 8.400E-5 3 40
6 GO:0009822 alkaloid catabolic process 3.633E-7 1.592E-5 9.795E-5 9.554E-5 2 3
7 GO:0016098 monoterpenoid metabolic process 1.815E-6 6.820E-5 4.195E-4 4.774E-4 2 6
8 GO:0009804 coumarin metabolic process 2.541E-6 7.792E-5 4.793E-4 6.683E-4 2 7
9 GO:0008202 steroid metabolic process 2.666E-6 7.792E-5 4.793E-4 7.013E-4 4 314
10 GO:0009698 phenylpropanoid metabolic process 3.387E-6 8.909E-5 5.480E-4 8.909E-4 2 8
11 GO:0042738 exogenous drug catabolic process 6.650E-6 1.590E-4 9.781E-4 1.749E-3 2 11
12 GO:0070989 oxidative demethylation 7.979E-6 1.749E-4 1.076E-3 2.098E-3 2 12
13 GO:0009820 alkaloid metabolic process 1.100E-5 2.225E-4 1.369E-3 2.892E-3 2 14
14 GO:0019369 arachidonic acid metabolic process 1.531E-4 2.875E-3 1.769E-2 4.026E-2 2 51
15 GO:0070988 demethylation 1.982E-4 3.475E-3 2.138E-2
5.212E-2
 2 58
16 GO:0019748 secondary metabolic process 2.266E-4 3.724E-3 2.291E-2
5.959E-2
 2 62
17 GO:0009914 hormone transport 2.566E-4 3.970E-3 2.442E-2
6.748E-2
 3 370
18 GO:0006631 fatty acid metabolic process 2.754E-4 4.024E-3 2.475E-2
7.243E-2
 3 379
19 GO:0090350 negative regulation of cellular organofluorine metabolic process 3.759E-4 4.119E-3 2.534E-2
9.886E-2
 1 1
20 GO:0090348 regulation of cellular organofluorine metabolic process 3.759E-4 4.119E-3 2.534E-2
9.886E-2
 1 1
21 GO:0090347 regulation of cellular organohalogen metabolic process 3.759E-4 4.119E-3 2.534E-2
9.886E-2
 1 1
22 GO:0015723 bilirubin transport 3.759E-4 4.119E-3 2.534E-2
9.886E-2
 1 1
23 GO:0090349 negative regulation of cellular organohalogen metabolic process 3.759E-4 4.119E-3 2.534E-2
9.886E-2
 1 1
24 GO:0033231 carbohydrate export 3.759E-4 4.119E-3 2.534E-2
9.886E-2
 1 1
25 GO:0001676 long-chain fatty acid metabolic process 4.669E-4 4.912E-3 3.022E-2
1.228E-1
 2 89
26 GO:0006805 xenobiotic metabolic process 5.430E-4 5.493E-3 3.379E-2
1.428E-1
 2 96
27 GO:0071466 cellular response to xenobiotic stimulus 6.008E-4 5.557E-3 3.418E-2
1.580E-1
 2 101
28 GO:1901568 fatty acid derivative metabolic process 6.127E-4 5.557E-3 3.418E-2
1.612E-1
 2 102
29 GO:0006690 icosanoid metabolic process 6.127E-4 5.557E-3 3.418E-2
1.612E-1
 2 102
30 GO:0009410 response to xenobiotic stimulus 6.993E-4 5.648E-3 3.474E-2
1.839E-1
 2 109
31 GO:0006721 terpenoid metabolic process 7.251E-4 5.648E-3 3.474E-2
1.907E-1
 2 111
32 GO:0090345 cellular organohalogen metabolic process 7.516E-4 5.648E-3 3.474E-2
1.977E-1
 1 2
33 GO:0090346 cellular organofluorine metabolic process 7.516E-4 5.648E-3 3.474E-2
1.977E-1
 1 2
34 GO:0046226 coumarin catabolic process 7.516E-4 5.648E-3 3.474E-2
1.977E-1
 1 2
35 GO:0043215 daunorubicin transport 7.516E-4 5.648E-3 3.474E-2
1.977E-1
 1 2
36 GO:0033559 unsaturated fatty acid metabolic process 7.779E-4 5.683E-3 3.496E-2
2.046E-1
 2 115
37 GO:0006720 isoprenoid metabolic process 1.054E-3 7.059E-3 4.342E-2
2.772E-1
 2 134
38 GO:0043134 regulation of hindgut contraction 1.127E-3 7.059E-3 4.342E-2
2.965E-1
 1 3
39 GO:0033076 isoquinoline alkaloid metabolic process 1.127E-3 7.059E-3 4.342E-2
2.965E-1
 1 3
40 GO:0046271 phenylpropanoid catabolic process 1.127E-3 7.059E-3 4.342E-2
2.965E-1
 1 3
41 GO:2001025 positive regulation of response to drug 1.127E-3 7.059E-3 4.342E-2
2.965E-1
 1 3
42 GO:0043133 hindgut contraction 1.127E-3 7.059E-3 4.342E-2
2.965E-1
 1 3
43 GO:0044108 cellular alcohol biosynthetic process 1.503E-3 8.066E-3 4.962E-2
3.952E-1
 1 4
44 GO:0036378 calcitriol biosynthetic process from calciol 1.503E-3 8.066E-3 4.962E-2
3.952E-1
 1 4
45 GO:0044107 cellular alcohol metabolic process 1.503E-3 8.066E-3 4.962E-2
3.952E-1
 1 4
46 GO:0032097 positive regulation of response to food 1.503E-3 8.066E-3 4.962E-2
3.952E-1
 1 4
47 GO:1901656 glycoside transport 1.503E-3 8.066E-3 4.962E-2
3.952E-1
 1 4
48 GO:0035633 maintenance of permeability of blood-brain barrier 1.503E-3 8.066E-3 4.962E-2
3.952E-1
 1 4
49 GO:0032100 positive regulation of appetite 1.503E-3 8.066E-3 4.962E-2
3.952E-1
 1 4
50 GO:0015718 monocarboxylic acid transport 1.669E-3 8.777E-3
5.399E-2
4.388E-1
 2 169
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 13 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0046581 intercellular canaliculus 4.157E-6 5.404E-5 1.718E-4 5.404E-5 2 9
2 GO:0005911 cell-cell junction 9.366E-3 4.248E-2
1.351E-1
1.218E-1
 2 418
3 GO:0045177 apical part of cell 9.803E-3 4.248E-2
1.351E-1
1.274E-1
 2 428

4: Human Phenotype [Display Chart] 6 input genes in category / 143 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 5 input genes in category / 164 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008875 abnormal xenobiotic pharmacokinetics 3.279E-10 5.378E-8 3.055E-7 5.378E-8 4 31
2 MP:0012226 increased sterol level 3.640E-4 1.584E-2
8.996E-2
5.969E-2
 3 350
3 MP:0003982 increased cholesterol level 3.640E-4 1.584E-2
8.996E-2
5.969E-2
 3 350
4 MP:0005037 mucous diarrhea 4.829E-4 1.584E-2
8.996E-2
7.919E-2
 1 1
5 MP:0011464 bilirubinuria 4.829E-4 1.584E-2
8.996E-2
7.919E-2
 1 1
6 MP:0005344 increased circulating bilirubin level 5.952E-4 1.627E-2
9.241E-2
9.762E-2
 2 81
7 MP:0001569 abnormal circulating bilirubin level 9.609E-4 1.759E-2
9.994E-2
1.576E-1
 2 103
8 MP:0004999 abnormal blood-inner ear barrier function 9.655E-4 1.759E-2
9.994E-2
1.583E-1
 1 2
9 MP:0004611 increased susceptibility to ototoxicity-induced hearing loss 9.655E-4 1.759E-2
9.994E-2
1.583E-1
 1 2
10 MP:0008401 abnormal CD8 positive, alpha-beta intraepithelial T cell morphology 2.894E-3 4.747E-2
2.696E-1
4.747E-1
 1 6
Show 5 more annotations

6: Domain [Display Chart] 7 input genes in category / 31 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR017972 Cyt P450 CS InterPro 7.422E-7 6.715E-6 2.704E-5 2.301E-5 3 53
2 PS00086 CYTOCHROME P450 PROSITE 9.265E-7 6.715E-6 2.704E-5 2.872E-5 3 57
3 1.10.630.10 - Gene3D 9.769E-7 6.715E-6 2.704E-5 3.028E-5 3 58
4 PF00067 p450 Pfam 9.769E-7 6.715E-6 2.704E-5 3.028E-5 3 58
5 IPR001128 Cyt P450 InterPro 1.083E-6 6.715E-6 2.704E-5 3.357E-5 3 60
6 PF00664 ABC membrane Pfam 3.290E-5 1.700E-4 6.845E-4 1.020E-3 2 24
7 PS50929 ABC TM1F PROSITE 4.502E-5 1.745E-4 7.026E-4 1.396E-3 2 28
8 IPR011527 ABC1 TM dom InterPro 4.502E-5 1.745E-4 7.026E-4 1.396E-3 2 28
9 IPR017871 ABC transporter CS InterPro 1.023E-4 3.218E-4 1.296E-3 3.171E-3 2 42
10 IPR002401 Cyt P450 E grp-I InterPro 1.176E-4 3.218E-4 1.296E-3 3.644E-3 2 45
11 PS50893 ABC TRANSPORTER 2 PROSITE 1.339E-4 3.218E-4 1.296E-3 4.150E-3 2 48
12 PF00005 ABC tran Pfam 1.339E-4 3.218E-4 1.296E-3 4.150E-3 2 48
13 PS00211 ABC TRANSPORTER 1 PROSITE 1.396E-4 3.218E-4 1.296E-3 4.326E-3 2 49
14 IPR003439 ABC transporter-like InterPro 1.453E-4 3.218E-4 1.296E-3 4.506E-3 2 50
15 IPR030247 ABCC2 InterPro 3.736E-4 7.722E-4 3.110E-3 1.158E-2 1 1
16 IPR003905 GHS-R InterPro 7.471E-4 1.362E-3 5.487E-3 2.316E-2 1 2
17 IPR008069 Cyt P450 E grp-I CYP2D-like InterPro 7.471E-4 1.362E-3 5.487E-3 2.316E-2 1 2
18 IPR003593 AAA+ ATPase InterPro 1.201E-3 1.960E-3 7.893E-3 3.724E-2 2 144
19 SM00382 AAA SMART 1.201E-3 1.960E-3 7.893E-3 3.724E-2 2 144
20 IPR008067 Cyt P450 E grp-I CYP2A-like InterPro 1.494E-3 2.205E-3 8.881E-3 4.631E-2 1 4
21 IPR005292 Multidrug-R assoc InterPro 1.494E-3 2.205E-3 8.881E-3 4.631E-2 1 4
22 IPR002402 Cyt P450 E grp-II InterPro 1.867E-3 2.631E-3 1.059E-2
5.788E-2
 1 5
23 IPR008072 Cyt P450 E CYP3A InterPro 2.240E-3 3.019E-3 1.216E-2
6.944E-2
 1 6
24 IPR004156 OA transporter InterPro 4.476E-3 5.550E-3 2.235E-2
1.387E-1
 1 12
25 PF03137 OATP Pfam 4.476E-3 5.550E-3 2.235E-2
1.387E-1
 1 12
26 PF07648 Kazal 2 Pfam 1.338E-2 1.595E-2
6.423E-2
4.146E-1
 1 36
27 SM00280 KAZAL SMART 1.706E-2 1.959E-2
7.890E-2
5.290E-1
 1 46
28 PS51465 KAZAL 2 PROSITE 1.854E-2 2.021E-2
8.138E-2
5.746E-1
 1 50
29 IPR002350 Kazal dom InterPro 1.890E-2 2.021E-2
8.138E-2
5.860E-1
 1 51
30 PS50850 MFS PROSITE 3.967E-2 4.099E-2
1.651E-1
1.000E0
 1 108
31 IPR020846 MFS dom InterPro 4.901E-2 4.901E-2
1.974E-1
1.000E0
 1 134
Show 26 more annotations

7: Pathway [Display Chart] 7 input genes in category / 63 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PW:0000729 statin pharmacokinetics pathway Pathway Ontology 1.084E-14 6.829E-13 3.229E-12 6.829E-13 5 13
2 193146 Bile secretion BioSystems: KEGG 3.355E-8 1.057E-6 4.997E-6 2.114E-6 4 71
3 1270194 Xenobiotics BioSystems: REACTOME 3.165E-7 6.225E-6 2.943E-5 1.994E-5 3 27
4 MAP00361 gamma Hexachlorocyclohexane degradation MAP00361 gamma Hexachlorocyclohexane degradation GenMAPP 3.952E-7 6.225E-6 2.943E-5 2.490E-5 3 29
5 MAP00380 Tryptophan metabolism MAP00380 Tryptophan metabolism GenMAPP 1.635E-6 1.717E-5 8.118E-5 1.030E-4 3 46
6 MAP00071 Fatty acid metabolism MAP00071 Fatty acid metabolism GenMAPP 1.635E-6 1.717E-5 8.118E-5 1.030E-4 3 46
7 1270191 Cytochrome P450 - arranged by substrate type BioSystems: REACTOME 5.863E-6 4.617E-5 2.183E-4 3.693E-4 3 70
8 83032 Drug metabolism - cytochrome P450 BioSystems: KEGG 5.863E-6 4.617E-5 2.183E-4 3.693E-4 3 70
9 83031 Metabolism of xenobiotics by cytochrome P450 BioSystems: KEGG 6.936E-6 4.855E-5 2.296E-4 4.370E-4 3 74
10 1270196 CYP2E1 reactions BioSystems: REACTOME 2.107E-5 1.328E-4 6.278E-4 1.328E-3 2 13
11 1270190 Phase 1 - Functionalization of compounds BioSystems: REACTOME 2.352E-5 1.347E-4 6.370E-4 1.482E-3 3 111
12 1270189 Biological oxidations BioSystems: REACTOME 2.036E-4 1.069E-3 5.053E-3 1.282E-2 3 229
13 83035 ABC transporters BioSystems: KEGG 2.652E-4 1.247E-3 5.898E-3 1.671E-2 2 45
14 83033 Drug metabolism - other enzymes BioSystems: KEGG 2.772E-4 1.247E-3 5.898E-3 1.746E-2 2 46
15 83020 Retinol metabolism BioSystems: KEGG 5.542E-4 2.214E-3 1.047E-2 3.492E-2 2 65
16 907948 estradiol biosynthesis II BioSystems: BIOCYC 5.622E-4 2.214E-3 1.047E-2 3.542E-2 1 1
17 673221 Chemical carcinogenesis BioSystems: KEGG 8.808E-4 3.264E-3 1.543E-2
5.549E-2
 2 82
18 PW:0000539 ghrelin system Pathway Ontology 1.124E-3 3.935E-3 1.860E-2
7.083E-2
 1 2
19 1269904 ABC-family proteins mediated transport BioSystems: REACTOME 1.578E-3 5.058E-3 2.391E-2
9.943E-2
 2 110
20 PW:0000727 nateglinide pharmacokinetics pathway Pathway Ontology 1.686E-3 5.058E-3 2.391E-2
1.062E-1
 1 3
21 PW:0000726 repaglinide pharmacokinetics pathway Pathway Ontology 1.686E-3 5.058E-3 2.391E-2
1.062E-1
 1 3
22 545303 estradiol biosynthesis I BioSystems: BIOCYC 2.247E-3 6.436E-3 3.043E-2
1.416E-1
 1 4
23 PW:0000381 multidrug resistance-associated protein mediated transport Pathway Ontology 2.809E-3 6.805E-3 3.218E-2
1.769E-1
 1 5
24 142436 bupropion degradation BioSystems: BIOCYC 2.809E-3 6.805E-3 3.218E-2
1.769E-1
 1 5
25 82945 Caffeine metabolism BioSystems: KEGG 2.809E-3 6.805E-3 3.218E-2
1.769E-1
 1 5
26 1270227 Abacavir transmembrane transport BioSystems: REACTOME 2.809E-3 6.805E-3 3.218E-2
1.769E-1
 1 5
27 PW:0000375 bioactivation via cytochrome P450 Pathway Ontology 3.369E-3 7.862E-3 3.717E-2
2.123E-1
 1 6
28 142438 nicotine degradation III BioSystems: BIOCYC 3.930E-3 8.843E-3 4.181E-2
2.476E-1
 1 7
29 545352 acetone degradation I (to methylglyoxal) BioSystems: BIOCYC 4.490E-3 9.755E-3 4.612E-2
2.829E-1
 1 8
30 545356 melatonin degradation I BioSystems: BIOCYC 5.610E-3 1.105E-2
5.223E-2
3.534E-1
 1 10
31 142437 nicotine degradation IV BioSystems: BIOCYC 5.610E-3 1.105E-2
5.223E-2
3.534E-1
 1 10
32 1270226 Abacavir transport and metabolism BioSystems: REACTOME 5.610E-3 1.105E-2
5.223E-2
3.534E-1
 1 10
33 545359 superpathway of melatonin degradation BioSystems: BIOCYC 6.170E-3 1.178E-2
5.569E-2
3.887E-1
 1 11
34 907943 superpathway of steroid hormone biosynthesis BioSystems: BIOCYC 6.729E-3 1.211E-2
5.727E-2
4.239E-1
 1 12
35 1269943 Transport of organic anions BioSystems: REACTOME 6.729E-3 1.211E-2
5.727E-2
4.239E-1
 1 12
36 PW:0000229 G protein signaling via Galphaq family Pathway Ontology 7.847E-3 1.336E-2
6.317E-2
4.944E-1
 1 14
37 1270200 Miscellaneous substrates BioSystems: REACTOME 7.847E-3 1.336E-2
6.317E-2
4.944E-1
 1 14
38 M16393 Nuclear Receptors in Lipid Metabolism and Toxicity MSigDB C2 BIOCARTA (v6.0) 8.405E-3 1.394E-2
6.589E-2
5.295E-1
 1 15
39 1270045 Recycling of bile acids and salts BioSystems: REACTOME 8.964E-3 1.448E-2
6.846E-2
5.647E-1
 1 16
40 P05914 Nicotine degradation PantherDB 9.521E-3 1.463E-2
6.918E-2
5.999E-1
 1 17
41 1270197 Fatty acids BioSystems: REACTOME 9.521E-3 1.463E-2
6.918E-2
5.999E-1
 1 17
42 SMP00260 Clopidogrel Pathway SMPDB 1.008E-2 1.512E-2
7.149E-2
6.350E-1
 1 18
43 M5202 Hypoxia and p53 in the Cardiovascular system MSigDB C2 BIOCARTA (v6.0) 1.286E-2 1.842E-2
8.709E-2
8.104E-1
 1 23
44 1270220 Aflatoxin activation and detoxification BioSystems: REACTOME 1.286E-2 1.842E-2
8.709E-2
8.104E-1
 1 23
45 82992 Linoleic acid metabolism BioSystems: KEGG 1.620E-2 2.267E-2
1.072E-1
1.000E0
 1 29
46 1440526 Antifolate resistance BioSystems: KEGG 1.730E-2 2.370E-2
1.121E-1
1.000E0
 1 31
47 835392 superpathway of tryptophan utilization BioSystems: BIOCYC 1.786E-2 2.394E-2
1.132E-1
1.000E0
 1 32
48 1269939 Transport of vitamins, nucleosides, and related molecules BioSystems: REACTOME 2.228E-2 2.924E-2
1.383E-1
1.000E0
 1 40
49 1270040 Bile acid and bile salt metabolism BioSystems: REACTOME 2.393E-2 3.077E-2
1.455E-1
1.000E0
 1 43
50 82940 Steroid hormone biosynthesis BioSystems: KEGG 3.217E-2 4.053E-2
1.916E-1
1.000E0
 1 58
Show 45 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 4905 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18509327 Pharmacogenetic pathway analysis of docetaxel elimination. Pubmed 1.974E-15 6.135E-12 5.568E-11 9.683E-12 4 5
2 20173083 Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans. Pubmed 2.502E-15 6.135E-12 5.568E-11 1.227E-11 5 27
3 18294295 Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Pubmed 1.382E-14 1.694E-11 1.538E-10 6.777E-11 4 7
4 18979093 Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in Vietnam. Pubmed 1.382E-14 1.694E-11 1.538E-10 6.777E-11 4 7
5 19343046 Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. Pubmed 1.074E-13 1.053E-10 9.557E-10 5.266E-10 6 193
6 20679960 Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients. Pubmed 2.765E-13 1.977E-10 1.794E-9 1.356E-9 5 66
7 16771603 Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population. Pubmed 2.821E-13 1.977E-10 1.794E-9 1.384E-9 4 13
8 21072184 Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition. Pubmed 1.911E-12 1.172E-9 1.063E-8 9.374E-9 4 20
9 19956635 Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. Pubmed 3.442E-12 1.876E-9 1.702E-8 1.688E-8 5 108
10 19865079 Population pharmacokinetics and pharmacogenetics of tacrolimus in de novo pediatric kidney transplant recipients. Pubmed 1.508E-11 6.723E-9 6.102E-8 7.395E-8 3 4
11 19228751 Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma. Pubmed 1.508E-11 6.723E-9 6.102E-8 7.395E-8 3 4
12 11809184 Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. Pubmed 3.769E-11 1.232E-8 1.119E-7 1.849E-7 3 5
13 18382661 Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample. Pubmed 3.769E-11 1.232E-8 1.119E-7 1.849E-7 3 5
14 20656072 Flexibility of human cytochrome P450 enzymes: molecular dynamics and spectroscopy reveal important function-related variations. Pubmed 3.769E-11 1.232E-8 1.119E-7 1.849E-7 3 5
15 19659438 CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti. Pubmed 3.769E-11 1.232E-8 1.119E-7 1.849E-7 3 5
16 20720558 Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia. Pubmed 7.538E-11 1.849E-8 1.678E-7 3.697E-7 3 6
17 20212519 Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity. Pubmed 7.538E-11 1.849E-8 1.678E-7 3.697E-7 3 6
18 18192894 Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphisms. Pubmed 7.538E-11 1.849E-8 1.678E-7 3.697E-7 3 6
19 18518855 A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine. Pubmed 7.538E-11 1.849E-8 1.678E-7 3.697E-7 3 6
20 15801936 Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer. Pubmed 7.538E-11 1.849E-8 1.678E-7 3.697E-7 3 6
21 19842932 Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients. Pubmed 1.319E-10 3.081E-8 2.796E-7 6.470E-7 3 7
22 20147896 A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir. Pubmed 2.110E-10 4.313E-8 3.914E-7 1.035E-6 3 8
23 18356043 Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. Pubmed 2.110E-10 4.313E-8 3.914E-7 1.035E-6 3 8
24 15680923 Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes. Pubmed 2.110E-10 4.313E-8 3.914E-7 1.035E-6 3 8
25 17178267 ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment. Pubmed 3.165E-10 6.210E-8 5.636E-7 1.552E-6 3 9
26 19651758 Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Pubmed 4.521E-10 8.213E-8 7.454E-7 2.218E-6 3 10
27 12960109 Irinotecan pathway genotype analysis to predict pharmacokinetics. Pubmed 4.521E-10 8.213E-8 7.454E-7 2.218E-6 3 10
28 15469410 Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pubmed 6.216E-10 1.016E-7 9.223E-7 3.049E-6 3 11
29 18695635 Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. Pubmed 6.216E-10 1.016E-7 9.223E-7 3.049E-6 3 11
30 15039299 Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Pubmed 6.216E-10 1.016E-7 9.223E-7 3.049E-6 3 11
31 19349540 Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. Pubmed 8.287E-10 1.311E-7 1.190E-6 4.065E-6 3 12
32 19636001 Racial differences in advanced colorectal cancer outcomes and pharmacogenetics: a subgroup analysis of a large randomized clinical trial. Pubmed 1.371E-9 2.038E-7 1.849E-6 6.725E-6 3 14
33 20970553 Toward personalized medicine in renal transplantation. Pubmed 1.371E-9 2.038E-7 1.849E-6 6.725E-6 3 14
34 19575027 Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility. Pubmed 1.714E-9 2.472E-7 2.244E-6 8.405E-6 3 15
35 20136364 Errors and reproducibility of DNA array-based detection of allelic variants in ADME genes: PHARMAchip. Pubmed 2.109E-9 2.873E-7 2.608E-6 1.034E-5 3 16
36 17925548 Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer. Pubmed 2.109E-9 2.873E-7 2.608E-6 1.034E-5 3 16
37 9890157 Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Pubmed 4.292E-9 5.689E-7 5.163E-6 2.105E-5 3 20
38 16006997 A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. Pubmed 8.655E-9 1.117E-6 1.014E-5 4.245E-5 3 25
39 20031551 Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response. Pubmed 1.691E-8 1.702E-6 1.544E-5 8.293E-5 3 31
40 24510399 Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects. Pubmed 2.879E-8 1.702E-6 1.544E-5 1.412E-4 2 2
41 15820320 Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms. Pubmed 2.879E-8 1.702E-6 1.544E-5 1.412E-4 2 2
42 19405050 Characterization of pharmacogenetically relevant CYP2D6 and ABCB1 gene polymorphisms in a Portuguese population sample. Pubmed 2.879E-8 1.702E-6 1.544E-5 1.412E-4 2 2
43 21039333 Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCC2 and their impact on drug disposition. Pubmed 2.879E-8 1.702E-6 1.544E-5 1.412E-4 2 2
44 22398969 Prediction of codeine toxicity in infants and their mothers using a novel combination of maternal genetic markers. Pubmed 2.879E-8 1.702E-6 1.544E-5 1.412E-4 2 2
45 25868121 The Influence of the CYP3A4*22 Polymorphism and CYP2D6 Polymorphisms on Serum Concentrations of Aripiprazole, Haloperidol, Pimozide, and Risperidone in Psychiatric Patients. Pubmed 2.879E-8 1.702E-6 1.544E-5 1.412E-4 2 2
46 16611851 Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice. Pubmed 2.879E-8 1.702E-6 1.544E-5 1.412E-4 2 2
47 19802823 Influence of genetic variation in CYP3A4 and ABCB1 on dose decrease or switching during simvastatin and atorvastatin therapy. Pubmed 2.879E-8 1.702E-6 1.544E-5 1.412E-4 2 2
48 21589866 Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response. Pubmed 2.879E-8 1.702E-6 1.544E-5 1.412E-4 2 2
49 16633141 Combined effects of itraconazole and CYP2D6*10 genetic polymorphism on the pharmacokinetics and pharmacodynamics of haloperidol in healthy subjects. Pubmed 2.879E-8 1.702E-6 1.544E-5 1.412E-4 2 2
50 18641553 CYP2D6 and ABCB1 genetic variability: influence on paroxetine plasma level and therapeutic response. Pubmed 2.879E-8 1.702E-6 1.544E-5 1.412E-4 2 2
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 87 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CYB5A CYB5A interactions 9.689E-8 8.430E-6 4.256E-5 8.430E-6 3 31
2 int:POR POR interactions 2.471E-7 1.075E-5 5.427E-5 2.150E-5 3 42
3 int:CYP2C9 CYP2C9 interactions 1.003E-5 2.909E-4 1.469E-3 8.728E-4 2 15
4 int:UGT1A6 UGT1A6 interactions 6.778E-4 1.263E-2
6.378E-2
5.896E-2
 1 2
5 int:GHSR GHSR interactions 1.016E-3 1.263E-2
6.378E-2
8.843E-2
 1 3
6 int:UGT2B7 UGT2B7 interactions 1.016E-3 1.263E-2
6.378E-2
8.843E-2
 1 3
7 int:CYP2A7 CYP2A7 interactions 1.016E-3 1.263E-2
6.378E-2
8.843E-2
 1 3
8 int:CYP2D6 CYP2D6 interactions 1.355E-3 1.473E-2
7.439E-2
1.179E-1
 1 4
9 int:CYP2A6 CYP2A6 interactions 1.694E-3 1.473E-2
7.439E-2
1.473E-1
 1 5
10 int:UGT1A1 UGT1A1 interactions 1.694E-3 1.473E-2
7.439E-2
1.473E-1
 1 5
11 int:CORT CORT interactions 3.385E-3 2.523E-2
1.274E-1
2.945E-1
 1 10
12 int:FBXO15 FBXO15 interactions 3.723E-3 2.523E-2
1.274E-1
3.239E-1
 1 11
13 int:GHRL GHRL interactions 4.061E-3 2.523E-2
1.274E-1
3.533E-1
 1 12
14 int:UBA7 UBA7 interactions 4.061E-3 2.523E-2
1.274E-1
3.533E-1
 1 12
15 int:CYP3A4 CYP3A4 interactions 5.411E-3 3.139E-2
1.585E-1
4.708E-1
 1 16
16 int:AZIN1 AZIN1 interactions 6.086E-3 3.268E-2
1.650E-1
5.295E-1
 1 18
17 int:ABCB1 ABCB1 interactions 6.423E-3 3.268E-2
1.650E-1
5.588E-1
 1 19
18 int:PDZD3 PDZD3 interactions 6.760E-3 3.268E-2
1.650E-1
5.882E-1
 1 20
19 int:TCIRG1 TCIRG1 interactions 7.434E-3 3.404E-2
1.719E-1
6.468E-1
 1 22
20 int:SYNJ2BP SYNJ2BP interactions 9.117E-3 3.872E-2
1.955E-1
7.932E-1
 1 27
21 int:PRR3 PRR3 interactions 9.454E-3 3.872E-2
1.955E-1
8.225E-1
 1 28
22 int:UBE2G1 UBE2G1 interactions 9.790E-3 3.872E-2
1.955E-1
8.517E-1
 1 29
23 int:SLC30A5 SLC30A5 interactions 1.181E-2 4.192E-2
2.116E-1
1.000E0
 1 35
24 int:RAB31 RAB31 interactions 1.181E-2 4.192E-2
2.116E-1
1.000E0
 1 35
25 int:OXA1L OXA1L interactions 1.281E-2 4.192E-2
2.116E-1
1.000E0
 1 38
26 int:FBXL13 FBXL13 interactions 1.382E-2 4.192E-2
2.116E-1
1.000E0
 1 41
27 int:MRPL57 MRPL57 interactions 1.415E-2 4.192E-2
2.116E-1
1.000E0
 1 42
28 int:TOMM70 TOMM70 interactions 1.449E-2 4.192E-2
2.116E-1
1.000E0
 1 43
29 int:ABCC2 ABCC2 interactions 1.650E-2 4.192E-2
2.116E-1
1.000E0
 1 49
30 int:GK GK interactions 1.683E-2 4.192E-2
2.116E-1
1.000E0
 1 50
31 int:PTRH2 PTRH2 interactions 1.750E-2 4.192E-2
2.116E-1
1.000E0
 1 52
32 int:PIM1 PIM1 interactions 1.783E-2 4.192E-2
2.116E-1
1.000E0
 1 53
33 int:TOMM20 TOMM20 interactions 1.850E-2 4.192E-2
2.116E-1
1.000E0
 1 55
34 int:NDUFA10 NDUFA10 interactions 1.917E-2 4.192E-2
2.116E-1
1.000E0
 1 57
35 int:PDZK1 PDZK1 interactions 1.917E-2 4.192E-2
2.116E-1
1.000E0
 1 57
36 int:BCCIP BCCIP interactions 1.950E-2 4.192E-2
2.116E-1
1.000E0
 1 58
37 int:PSMB8 PSMB8 interactions 2.050E-2 4.192E-2
2.116E-1
1.000E0
 1 61
38 int:RAB14 RAB14 interactions 2.083E-2 4.192E-2
2.116E-1
1.000E0
 1 62
39 int:NDUFS8 NDUFS8 interactions 2.083E-2 4.192E-2
2.116E-1
1.000E0
 1 62
40 int:MRPL23 MRPL23 interactions 2.117E-2 4.192E-2
2.116E-1
1.000E0
 1 63
41 int:MRPS26 MRPS26 interactions 2.117E-2 4.192E-2
2.116E-1
1.000E0
 1 63
42 int:PGRMC1 PGRMC1 interactions 2.150E-2 4.192E-2
2.116E-1
1.000E0
 1 64
43 int:MRPS28 MRPS28 interactions 2.183E-2 4.192E-2
2.116E-1
1.000E0
 1 65
44 int:NDUFB9 NDUFB9 interactions 2.183E-2 4.192E-2
2.116E-1
1.000E0
 1 65
45 int:ATP6V1E1 ATP6V1E1 interactions 2.183E-2 4.192E-2
2.116E-1
1.000E0
 1 65
46 int:MRPL24 MRPL24 interactions 2.216E-2 4.192E-2
2.116E-1
1.000E0
 1 66
47 int:RABAC1 RABAC1 interactions 2.449E-2 4.534E-2
2.289E-1
1.000E0
 1 73
48 int:UQCRFS1 UQCRFS1 interactions 2.582E-2 4.598E-2
2.321E-1
1.000E0
 1 77
49 int:MRPL37 MRPL37 interactions 2.714E-2 4.598E-2
2.321E-1
1.000E0
 1 81
50 int:NDUFA2 NDUFA2 interactions 2.748E-2 4.598E-2
2.321E-1
1.000E0
 1 82
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7q21.1 7q21.1 1.615E-3 5.651E-3 1.465E-2 1.130E-2 1 8
2 7q21.12 7q21.12 1.615E-3 5.651E-3 1.465E-2 1.130E-2 1 8
3 12p12 12p12 2.623E-3 6.000E-3 1.556E-2 1.836E-2 1 13
4 3q26.31 3q26.31 3.429E-3 6.000E-3 1.556E-2 2.400E-2 1 17
5 10q24 10q24 7.048E-3 9.867E-3 2.558E-2 4.933E-2 1 35
6 22q13.1 22q13.1 1.784E-2 2.081E-2
5.396E-2
1.249E-1
 1 89
7 19q13.2 19q13.2 3.364E-2 3.364E-2
8.722E-2
2.355E-1
 1 169
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 13 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1001 Cytochrome P450 family 2 genenames.org 7.504E-5 5.253E-4 1.362E-3 5.253E-4 2 35
2 220 Peptide receptors genenames.org 2.691E-3 6.988E-3 1.812E-2 1.883E-2 1 7
3 1002 Cytochrome P450 family 3 genenames.org 3.074E-3 6.988E-3 1.812E-2 2.152E-2 1 8
4 806 ATP binding cassette subfamily B genenames.org 4.225E-3 6.988E-3 1.812E-2 2.958E-2 1 11
5 807 ATP binding cassette subfamily C genenames.org 4.992E-3 6.988E-3 1.812E-2 3.494E-2 1 13

13: Coexpression [Display Chart] 7 input genes in category / 512 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15084249-Table2 Human Breast Bieche04 27genes GeneSigDB 5.133E-11 2.628E-8 1.792E-7 2.628E-8 4 27
2 18318837-Table1 Human MesenchymalStemCells Yamamoto08 83genes GeneSigDB 4.371E-9 1.119E-6 7.628E-6 2.238E-6 4 79
3 M13283 Liver selective genes MSigDB C2: CGP Curated Gene Sets (v6.0) 4.120E-7 7.032E-5 4.793E-4 2.110E-4 4 244
4 M1676 Genes whose expression negatively correlated with that of SMARCA2 [GeneID=6595] in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.860E-6 2.381E-4 1.623E-3 9.522E-4 4 356
5 15899800-TableS1 Human Breast Martens05 117genes GeneSigDB 4.235E-6 4.337E-4 2.956E-3 2.169E-3 3 116
6 M1141 Detoxification pathway genes down-regulated in enterocytes of transgenic mice expressing SV40 T antigen. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.110E-6 5.214E-4 3.554E-3 3.128E-3 2 13
7 M6145 Genes highly expressed in hepatocellular carcinoma with good survival. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.719E-5 1.258E-3 8.572E-3 8.803E-3 3 185
8 M6307 Genes up-regulated in macrophages stimulated by IFNG [GeneID=3458] for 24h: control versus primed by IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 2.171E-5 1.389E-3 9.470E-3 1.111E-2 3 200
9 15604263-Table2 Human StemCell Gillet04 57genes GeneSigDB 3.633E-5 2.067E-3 1.409E-2 1.860E-2 2 31
10 18221535-Table2 Human Liver Parent08 55genes GeneSigDB 5.199E-5 2.662E-3 1.815E-2 2.662E-2 2 37
11 19266166-Table1 Human Eye+J425 Hendig09 48genes GeneSigDB 8.427E-5 3.922E-3 2.674E-2 4.315E-2 2 47
12 M9206 Genes down-regulated in hepatocellular carcinoma (HCC) cells with hepatic stem cell properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.212E-4 9.440E-3
6.435E-2
1.133E-1
 2 76
13 19462257-Table2 Human Prostate Zhang09 84genes GeneSigDB 2.576E-4 1.014E-2
6.915E-2
1.319E-1
 2 82
14 M4270 Downregulated in the vastus lateralis muscle of middle aged rhesus monkeys subjected to caloric restriction since young adulthood vs age matched controls MSigDB C2: CGP Curated Gene Sets (v6.0) 2.833E-4 1.036E-2
7.063E-2
1.451E-1
 2 86
15 M5759 Genes up-regulated in comparison of untreated macrophages versus those treated with IL1. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.988E-2
2.037E-1
7.692E-1
 2 199
16 M2918 Genes down-regulated in skin after injection of Trypanosoma cruzi (strain Y): wildtype (BALB/c) versus IFNAR1 [GeneID=3454] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.988E-2
2.037E-1
7.692E-1
 2 199
17 19672972-Table1 Human Leukemia Cortez09 5genes GeneSigDB 1.512E-3 2.988E-2
2.037E-1
7.741E-1
 1 5
18 M4327 Genes up-regulated in comparison of TconvLP versus DEC-Pept CD25- (see Table S1 in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.988E-2
2.037E-1
7.769E-1
 2 200
19 M6952 Genes down-regulated in plasmacytoid dendritic cells (1h): CpG oligodeoxynucleotide 1826 versus influenza virus infection. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.988E-2
2.037E-1
7.769E-1
 2 200
20 M9278 Genes up-regulated in CD8 T cells 3 days after immunization: control versus IL2 [GeneID=3558] treatment. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.988E-2
2.037E-1
7.769E-1
 2 200
21 M5092 Genes down-regulated in comparison of memory CD8 T cells treated with IL7 [GeneID=3574] versus those treated with IL4 [GeneID=3565] and IL7 [GeneID=3574]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.988E-2
2.037E-1
7.769E-1
 2 200
22 M8170 Genes up-regulated in HEK293 cells: expressing mutant NOD2 [GeneID=64127] versus control. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.988E-2
2.037E-1
7.769E-1
 2 200
23 M3478 Genes up-regulated in comparison of CD4 [GeneID=920] thymocytes versus thymic stromal cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.988E-2
2.037E-1
7.769E-1
 2 200
24 M4886 Genes up-regulated in comparison of follicular B cells versus late germinal center (GC) B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.988E-2
2.037E-1
7.769E-1
 2 200
25 M3203 Genes up-regulated in comparison of pre-germinal center B cells versus dark zone germinal center B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.988E-2
2.037E-1
7.769E-1
 2 200
26 M7335 Genes up-regulated in HMC-1 (mast leukemia) cells: untreated versus incubated with the peptide ALL1 followed by stimulation with T cell membranes. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.988E-2
2.037E-1
7.769E-1
 2 200
27 M12825 Up-regulated genes common to all pretumorigenic cells with acquired drug resistance. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.418E-3 4.586E-2
3.126E-1
1.000E0
 1 8
28 M13449 Genes down-regulated in hepatoblastoma samples compared to normal liver tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.682E-3 4.678E-2
3.189E-1
1.000E0
 2 267
29 17284363-Table4 Human Lung Yabuki07 10genes GeneSigDB 2.720E-3 4.678E-2
3.189E-1
1.000E0
 1 9
30 M11472 Genes down-regulated in three-dimentional (3D) cultures of preinvasive (S3-C) vs invasive (T4-2) breast cancer cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.741E-3 4.678E-2
3.189E-1
1.000E0
 2 270
31 M9371 Top genes up-regulated in colon epithelium biopsies from FAP (familial adenomatous polyposis) patients with mutated APC [GeneID=324]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.022E-3 4.991E-2
3.402E-1
1.000E0
 1 10
Show 26 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 300 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 liver liver Human Protein Atlas 5.177E-8 1.553E-5 9.758E-5 1.553E-5 5 419
2 small intestine small intestine Human Protein Atlas 1.928E-6 2.892E-4 1.817E-3 5.783E-4 4 339
3 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Mucinous/2/3 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Mucinous/2/3 TCGA-Stomach 1.299E-5 1.255E-3 7.882E-3 3.897E-3 3 159
4 Sample Type by Project: Shred 1/TCGA-Liver/Hepatocellular Carcinoma/Hepatocellular Carcinoma/5 Sample Type by Project: Shred 1/TCGA-Liver/Hepatocellular Carcinoma/Hepatocellular Carcinoma/5 TCGA-Liver 1.673E-5 1.255E-3 7.882E-3 5.018E-3 3 173
5 duodenum duodenum Human Protein Atlas 1.055E-4 6.332E-3 3.978E-2 3.166E-2 3 321
6 gudmap kidney adult JuxtaGlom Ren1 Captopr 500 kidney adult JuxtaGlom Ren1 Captopr top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.130E-4 1.065E-2
6.691E-2
6.390E-2
 3 407
7 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/4/3 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/4/3 TCGA-Stomach 8.279E-4 3.548E-2
2.229E-1
2.484E-1
 2 139
8 BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/Striatum/Striatum/Endothelial Stalk BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/Striatum/Striatum/Endothelial Stalk BrainMap 1.923E-3 4.805E-2
3.019E-1
5.768E-1
 1 6
9 BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/Hippocampus/Hippocampus/Endothelial Stalk BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/Hippocampus/Hippocampus/Endothelial Stalk BrainMap 1.923E-3 4.805E-2
3.019E-1
5.768E-1
 1 6
10 BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/Entopeduncular/Entopeduncular/Endothelial Stalk BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/Entopeduncular/Entopeduncular/Endothelial Stalk BrainMap 2.243E-3 4.805E-2
3.019E-1
6.729E-1
 1 7
11 BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/GlobusPallidus/GlobusPallidus/Endothelial Stalk BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/GlobusPallidus/GlobusPallidus/Endothelial Stalk BrainMap 2.243E-3 4.805E-2
3.019E-1
6.729E-1
 1 7
12 BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/Cerebellum/Cerebellum/Endothelial Stalk BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/Cerebellum/Cerebellum/Endothelial Stalk BrainMap 2.243E-3 4.805E-2
3.019E-1
6.729E-1
 1 7
13 BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/FrontalCortex/FrontalCortex/Endothelial Stalk BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/FrontalCortex/FrontalCortex/Endothelial Stalk BrainMap 2.243E-3 4.805E-2
3.019E-1
6.729E-1
 1 7
14 BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/PosteriorCortex/PosteriorCortex/Endothelial Stalk BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/PosteriorCortex/PosteriorCortex/Endothelial Stalk BrainMap 2.243E-3 4.805E-2
3.019E-1
6.729E-1
 1 7
15 facebase RNAseq e14.5 palate poster proximal ERK2 WT 2500 K3 facebase RNAseq e14.5 palate poster proximal ERK2 WT 2500 K3 Gudmap RNAseq 2.438E-3 4.805E-2
3.019E-1
7.313E-1
 2 240
16 BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/SubstantiaNigra/SubstantiaNigra/Endothelial Stalk BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/SubstantiaNigra/SubstantiaNigra/Endothelial Stalk BrainMap 2.563E-3 4.805E-2
3.019E-1
7.689E-1
 1 8
Show 11 more annotations

15: Computational [Display Chart] 5 input genes in category / 69 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M8592 MODULE 135 Genes in the cancer module 135. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.361E-7 9.389E-6 4.524E-5 9.389E-6 3 25
2 M5646 MODULE 106 Cytochrome P450. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.802E-5 6.219E-4 2.996E-3 1.244E-3 2 14
3 M19409 GNF2 CYP2B6 Neighborhood of CYP2B6 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.313E-4 4.670E-3 2.250E-2 1.596E-2 2 49
4 M4363 MORF ARL3 Neighborhood of ARL3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.707E-4 4.670E-3 2.250E-2 1.868E-2 3 307
5 M3221 GNF2 CEBPA Neighborhood of CEBPA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.953E-4 5.456E-3 2.629E-2 2.728E-2 2 64
6 M1890 MORF MYL3 Neighborhood of MYL3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.866E-4 5.596E-3 2.697E-2 3.358E-2 2 71
7 M17919 GNF2 TST Neighborhood of TST MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.042E-3 9.866E-3 4.754E-2
7.190E-2
 2 104
8 M10693 GNF2 GSTM1 Neighborhood of GSTM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.144E-3 9.866E-3 4.754E-2
7.893E-2
 2 109
9 M132 GNF2 LCAT Neighborhood of LCAT MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.478E-3 1.097E-2
5.286E-2
1.020E-1
 2 124
10 M10917 GNF2 HPN Neighborhood of HPN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.698E-3 1.097E-2
5.286E-2
1.171E-1
 2 133
11 M14108 GNF2 HPX Neighborhood of HPX MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.749E-3 1.097E-2
5.286E-2
1.207E-1
 2 135
12 M6373 MORF NF1 Neighborhood of NF1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.726E-3 1.567E-2
7.553E-2
1.881E-1
 2 169
13 M18890 MODULE 7 Genes in the cancer module 7. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.385E-3 2.698E-2
1.300E-1
3.716E-1
 2 239
14 M19290 MORF IL16 Neighborhood of IL16 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.473E-3 2.698E-2
1.300E-1
3.777E-1
 2 241
15 M18296 MORF TNFRSF25 Neighborhood of TNFRSF25 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.734E-3 3.098E-2
1.493E-1
4.647E-1
 2 268
16 M8621 MORF NOS2A Neighborhood of NOS2A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.905E-3 3.252E-2
1.567E-1
5.455E-1
 2 291
17 M2749 MORF CAMK4 Neighborhood of CAMK4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.011E-3 3.252E-2
1.567E-1
5.528E-1
 2 293
18 M426 MORF MLLT10 Neighborhood of MLLT10 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.606E-3 3.299E-2
1.590E-1
5.938E-1
 2 304
19 M19749 MORF ERCC4 Neighborhood of ERCC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.797E-3 3.502E-2
1.687E-1
6.760E-1
 2 325
20 M7214 MORF SUPT3H Neighborhood of SUPT3H MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.015E-2 3.502E-2
1.687E-1
7.003E-1
 2 331
21 M16314 GNF2 IGF1 Neighborhood of IGF1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.289E-2 4.235E-2
2.040E-1
8.893E-1
 1 26
22 M11755 MORF RAD51L3 Neighborhood of RAD51L3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.400E-2 4.390E-2
2.116E-1
9.659E-1
 2 391
23 M6407 MORF FOSL1 Neighborhood of FOSL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.526E-2 4.579E-2
2.206E-1
1.000E0
 2 409
24 M3103 MORF MAGEA9 Neighborhood of MAGEA9 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.658E-2 4.766E-2
2.296E-1
1.000E0
 2 427
Show 19 more annotations

16: MicroRNA [Display Chart] 7 input genes in category / 41 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-609:mirSVR highEffct hsa-miR-609:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.686E-4 3.151E-2
1.356E-1
 3.151E-2 2 442
2 hsa-miR-451a:Functional MTI Functional MTI miRTarbase 3.000E-3 3.422E-2
1.472E-1
1.230E-1
 1 31
3 hsa-miR-491-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.607E-3 3.422E-2
1.472E-1
2.299E-1
 1 58
4 hsa-miR-3936:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.185E-3 3.422E-2
1.472E-1
2.536E-1
 1 64
5 hsa-miR-181c*:mirSVR highEffct hsa-miR-181c*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.266E-3 3.422E-2
1.472E-1
3.799E-1
 1 96
6 hsa-miR-223-3p:Functional MTI Functional MTI miRTarbase 9.458E-3 3.422E-2
1.472E-1
3.878E-1
 1 98
7 hsa-miR-889-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.013E-2 3.422E-2
1.472E-1
4.153E-1
 1 105
8 hsa-miR-9-3p:Functional MTI Functional MTI miRTarbase 1.013E-2 3.422E-2
1.472E-1
4.153E-1
 1 105
9 hsa-miR-4457:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.061E-2 3.422E-2
1.472E-1
4.350E-1
 1 110
10 hsa-miR-1292:mirSVR highEffct hsa-miR-1292:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.215E-2 3.422E-2
1.472E-1
4.980E-1
 1 126
11 hsa-miR-488-3p:Functional MTI Functional MTI miRTarbase 1.263E-2 3.422E-2
1.472E-1
5.176E-1
 1 131
12 hsa-miR-188-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.301E-2 3.422E-2
1.472E-1
5.334E-1
 1 135
13 hsa-miR-561-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.358E-2 3.422E-2
1.472E-1
5.569E-1
 1 141
14 hsa-miR-510-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.607E-2 3.422E-2
1.472E-1
6.589E-1
 1 167
15 hsa-miR-495-3p:Functional MTI Functional MTI miRTarbase 1.769E-2 3.422E-2
1.472E-1
7.255E-1
 1 184
16 hsa-miR-4639-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.798E-2 3.422E-2
1.472E-1
7.372E-1
 1 187
17 hsa-miR-1470:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.855E-2 3.422E-2
1.472E-1
7.607E-1
 1 193
18 hsa-miR-34b-3p:Functional MTI Functional MTI miRTarbase 1.941E-2 3.422E-2
1.472E-1
7.958E-1
 1 202
19 hsa-miR-7113-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.970E-2 3.422E-2
1.472E-1
8.076E-1
 1 205
20 hsa-miR-6867-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.017E-2 3.422E-2
1.472E-1
8.271E-1
 1 210
21 hsa-miR-5590-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.036E-2 3.422E-2
1.472E-1
8.349E-1
 1 212
22 hsa-miR-361-5p:TargetScan hsa-miR-361-5p TargetScan 2.055E-2 3.422E-2
1.472E-1
8.427E-1
 1 214
23 hsa-miR-490-3p:Functional MTI Functional MTI miRTarbase 2.055E-2 3.422E-2
1.472E-1
8.427E-1
 1 214
24 hsa-miR-532-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.112E-2 3.422E-2
1.472E-1
8.661E-1
 1 220
25 hsa-miR-142-5p:Functional MTI Functional MTI miRTarbase 2.160E-2 3.422E-2
1.472E-1
8.856E-1
 1 225
26 hsa-miR-4667-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.388E-2 3.422E-2
1.472E-1
9.791E-1
 1 249
27 hsa-miR-4789-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.435E-2 3.422E-2
1.472E-1
9.986E-1
 1 254
28 hsa-miR-873-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.549E-2 3.422E-2
1.472E-1
1.000E0
 1 266
29 hsa-miR-150-5p:TargetScan hsa-miR-150-5p TargetScan 2.549E-2 3.422E-2
1.472E-1
1.000E0
 1 266
30 hsa-miR-4685-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.578E-2 3.422E-2
1.472E-1
1.000E0
 1 269
31 hsa-miR-4287:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.587E-2 3.422E-2
1.472E-1
1.000E0
 1 270
32 hsa-miR-4789-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.805E-2 3.594E-2
1.546E-1
1.000E0
 1 293
33 hsa-miR-4469:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.947E-2 3.640E-2
1.566E-1
1.000E0
 1 308
34 hsa-miR-718:mirSVR lowEffct hsa-miR-718:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.022E-2 3.640E-2
1.566E-1
1.000E0
 1 316
35 hsa-miR-615-5p:mirSVR highEffct hsa-miR-615-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.107E-2 3.640E-2
1.566E-1
1.000E0
 1 325
36 hsa-miR-340-5p:Functional MTI Functional MTI miRTarbase 3.258E-2 3.710E-2
1.597E-1
1.000E0
 1 341
37 hsa-miR-27b-3p:Functional MTI Functional MTI miRTarbase 4.009E-2 4.406E-2
1.896E-1
1.000E0
 1 421
38 hsa-miR-3941:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.084E-2 4.406E-2
1.896E-1
1.000E0
 1 429
39 hsa-miR-1914*:mirSVR highEffct hsa-miR-1914*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.532E-2 4.645E-2
1.999E-1
1.000E0
 1 477
40 hsa-miR-508-5p:Functional MTI Functional MTI miRTarbase 4.532E-2 4.645E-2
1.999E-1
1.000E0
 1 477
41 hsa-miR-490-3p:mirSVR highEffct hsa-miR-490-3p:mirSVR conserved highEffect-0.5 MicroRNA.org 4.736E-2 4.736E-2
2.038E-1
1.000E0
 1 499
Show 36 more annotations

17: Drug [Display Chart] 7 input genes in category / 5392 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000119057 AC1L3O4Q Stitch 1.764E-13 5.823E-10 5.340E-9 9.509E-10 5 37
2 ctd:D005672 Fusidic Acid CTD 2.160E-13 5.823E-10 5.340E-9 1.165E-9 4 8
3 ctd:C058309 hypaconitine CTD 6.479E-13 1.048E-9 9.608E-9 3.493E-9 4 10
4 CID000627275 AC1LCF1F Stitch 7.773E-13 1.048E-9 9.608E-9 4.191E-9 6 161
5 CID000002756 cimetidine Stitch 1.481E-12 1.597E-9 1.465E-8 7.987E-9 6 179
6 CID003035604 7-benzyloxyquinoline Stitch 9.432E-12 7.468E-9 6.848E-8 5.086E-8 4 18
7 ctd:D019826 Cholic Acid CTD 9.695E-12 7.468E-9 6.848E-8 5.228E-8 5 80
8 ctd:D008095 Lithocholic Acid CTD 1.151E-11 7.756E-9 7.112E-8 6.205E-8 6 251
9 CID000157574 CI-1034 Stitch 2.254E-11 1.350E-8 1.238E-7 1.215E-7 4 22
10 ctd:D007559 Ivermectin CTD 3.190E-11 1.720E-8 1.577E-7 1.720E-7 5 101
11 CID005381226 rifampicin Stitch 3.811E-11 1.751E-8 1.605E-7 2.055E-7 6 306
12 ctd:C047781 lamotrigine CTD 3.896E-11 1.751E-8 1.605E-7 2.101E-7 4 25
13 ctd:D014700 Verapamil CTD 4.702E-11 1.950E-8 1.788E-7 2.535E-7 5 109
14 ctd:C061004 benidipine CTD 5.405E-11 2.082E-8 1.909E-7 2.914E-7 4 27
15 ctd:D009543 Nifedipine CTD 6.739E-11 2.422E-8 2.221E-7 3.634E-7 5 117
16 ctd:D008874 Midazolam CTD 8.437E-11 2.676E-8 2.454E-7 4.549E-7 4 30
17 ctd:D017336 Loratadine CTD 8.437E-11 2.676E-8 2.454E-7 4.549E-7 4 30
18 ctd:D012293 Rifampin CTD 9.991E-11 2.993E-8 2.745E-7 5.387E-7 6 359
19 ctd:C501277 Mangifera indica extract CTD 1.107E-10 3.141E-8 2.880E-7 5.968E-7 4 32
20 CID005481990 L-754,394 Stitch 1.762E-10 4.653E-8 4.267E-7 9.501E-7 3 5
21 ctd:C054919 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene CTD 1.812E-10 4.653E-8 4.267E-7 9.772E-7 4 36
22 CID000005076 ABT-538 Stitch 2.218E-10 5.323E-8 4.881E-7 1.196E-6 5 148
23 CID000004635 AC1L1ILY Stitch 2.271E-10 5.323E-8 4.881E-7 1.224E-6 4 38
24 ctd:D009529 Nicardipine CTD 2.530E-10 5.683E-8 5.212E-7 1.364E-6 4 39
25 ctd:C082026 tebufenozide CTD 3.524E-10 7.037E-8 6.453E-7 1.900E-6 3 6
26 ctd:C050699 mepirodipine CTD 3.524E-10 7.037E-8 6.453E-7 1.900E-6 3 6
27 ctd:D000927 Anticonvulsants CTD 3.524E-10 7.037E-8 6.453E-7 1.900E-6 3 6
28 CID000003510 Kytril Stitch 4.580E-10 8.819E-8 8.087E-7 2.469E-6 4 45
29 CID000008439 AC1L1R04 Stitch 5.481E-10 1.019E-7 9.345E-7 2.955E-6 4 47
30 CID000003255 erythromycin A Stitch 8.472E-10 1.523E-7 1.396E-6 4.568E-6 5 193
31 ctd:C477042 ginkgolide A CTD 9.864E-10 1.612E-7 1.478E-6 5.318E-6 3 8
32 CID000153982 L-754394 Stitch 9.864E-10 1.612E-7 1.478E-6 5.318E-6 3 8
33 CID003035848 nicotine glucuronide Stitch 9.864E-10 1.612E-7 1.478E-6 5.318E-6 3 8
34 ctd:C121345 desloratadine CTD 1.479E-9 2.241E-7 2.055E-6 7.977E-6 3 9
35 ctd:C545880 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide CTD 1.479E-9 2.241E-7 2.055E-6 7.977E-6 3 9
36 CID000012547 5 beta-pregnanediol Stitch 1.496E-9 2.241E-7 2.055E-6 8.069E-6 4 60
37 ctd:C026209 oltipraz CTD 1.601E-9 2.334E-7 2.140E-6 8.634E-6 4 61
38 ctd:D011802 Quinidine CTD 1.712E-9 2.429E-7 2.227E-6 9.229E-6 4 62
39 ctd:C088453 Celsior CTD 2.113E-9 2.921E-7 2.679E-6 1.139E-5 3 10
40 CID000015032 pregnenolone-16 alpha-carbonitrile Stitch 2.350E-9 3.091E-7 2.835E-6 1.267E-5 4 67
41 ctd:D017035 Pravastatin CTD 2.350E-9 3.091E-7 2.835E-6 1.267E-5 4 67
42 CID000003404 (Z) Fluvoxamine Stitch 2.651E-9 3.133E-7 2.873E-6 1.429E-5 4 69
43 CID000003062 Digocin Stitch 2.811E-9 3.133E-7 2.873E-6 1.516E-5 4 70
44 CID000004112 NSC 117356 Stitch 2.871E-9 3.133E-7 2.873E-6 1.548E-5 5 246
45 CID000216236 Ticalopride Stitch 2.905E-9 3.133E-7 2.873E-6 1.566E-5 3 11
46 ctd:C008838 phenthoate CTD 2.905E-9 3.133E-7 2.873E-6 1.566E-5 3 11
47 CID000108104 sphondin Stitch 2.905E-9 3.133E-7 2.873E-6 1.566E-5 3 11
48 ctd:C507866 trans-1,2-dihydro-1,2-naphthalenediol CTD 2.905E-9 3.133E-7 2.873E-6 1.566E-5 3 11
49 ctd:C487413 5-methoxyindole CTD 2.905E-9 3.133E-7 2.873E-6 1.566E-5 3 11
50 ctd:D014217 Troleandomycin CTD 2.905E-9 3.133E-7 2.873E-6 1.566E-5 3 11
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 676 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0027947 Neutropenia DisGeNET Curated 1.940E-9 1.311E-6 9.302E-6 1.311E-6 5 162
2 C0008370 Cholestasis DisGeNET Curated 5.607E-9 1.895E-6 1.345E-5 3.791E-6 5 200
3 C0023530 Leukopenia DisGeNET Curated 1.288E-8 2.902E-6 2.059E-5 8.707E-6 5 236
4 C0011991 Diarrhea DisGeNET Curated 5.646E-8 9.541E-6 6.769E-5 3.817E-5 5 317
5 C0030201 Pain, Postoperative DisGeNET Curated 8.709E-8 1.121E-5 7.954E-5 5.887E-5 3 23
6 C0087169 Withdrawal Symptoms DisGeNET BeFree 9.951E-8 1.121E-5 7.954E-5 6.727E-5 3 24
7 C1623038 Cirrhosis DisGeNET BeFree 1.758E-7 1.698E-5 1.204E-4 1.188E-4 5 398
8 C0220991 Rotor Syndrome DisGeNET Curated 4.797E-7 4.054E-5 2.876E-4 3.243E-4 2 3
9 C0020433 Hyperbilirubinemia DisGeNET Curated 1.081E-6 7.307E-5 5.184E-4 7.307E-4 3 52
10 C0563625 Agnosia for Pain DisGeNET BeFree 1.081E-6 7.307E-5 5.184E-4 7.307E-4 3 52
11 C1096063 Drug Resistant Epilepsy DisGeNET BeFree 1.355E-6 7.718E-5 5.476E-4 9.159E-4 3 56
12 C1565489 Renal Insufficiency DisGeNET Curated 1.508E-6 7.718E-5 5.476E-4 1.020E-3 4 237
13 C0860207 Drug-Induced Liver Disease DisGeNET BeFree 1.588E-6 7.718E-5 5.476E-4 1.073E-3 3 59
14 C0151559 Central nervous system depression (disorder) DisGeNET BeFree 1.598E-6 7.718E-5 5.476E-4 1.081E-3 2 5
15 C0041755 Adverse reaction to drug DisGeNET Curated 1.757E-6 7.920E-5 5.619E-4 1.188E-3 3 61
16 C0750384 Coumarin Resistance DisGeNET Curated 2.397E-6 1.013E-4 7.185E-4 1.621E-3 2 6
17 C0008312 Primary biliary cirrhosis DisGeNET Curated 2.612E-6 1.039E-4 7.368E-4 1.766E-3 4 272
18 C0520909 Postoperative Nausea and Vomiting DisGeNET BeFree 3.355E-6 1.218E-4 8.640E-4 2.268E-3 2 7
19 C0009782 Connective Tissue Diseases DisGeNET Curated 3.423E-6 1.218E-4 8.640E-4 2.314E-3 3 76
20 C0019158 Hepatitis DisGeNET Curated 3.706E-6 1.253E-4 8.886E-4 2.505E-3 4 297
21 C0400966 Non-alcoholic Fatty Liver Disease DisGeNET Curated 4.801E-6 1.545E-4 1.096E-3 3.246E-3 4 317
22 C0022354 Jaundice, Obstructive DisGeNET Curated 5.750E-6 1.767E-4 1.253E-3 3.887E-3 2 9
23 C0809983 Schizophrenia and related disorders DisGeNET Curated 1.245E-5 3.659E-4 2.595E-3 8.415E-3 2 13
24 C0023452 Leukemia, Lymphocytic, Acute, L1 DisGeNET BeFree 1.463E-5 4.122E-4 2.924E-3 9.893E-3 4 420
25 C0032708 Disorders of Porphyrin Metabolism DisGeNET Curated 1.675E-5 4.355E-4 3.089E-3 1.132E-2 2 15
26 C0596240 Cancer Pain DisGeNET BeFree 1.675E-5 4.355E-4 3.089E-3 1.132E-2 2 15
27 C0149958 Complex partial seizures DisGeNET Curated 1.914E-5 4.502E-4 3.194E-3 1.294E-2 2 16
28 C0153467 Malignant tumor of peritoneum DisGeNET BeFree 1.914E-5 4.502E-4 3.194E-3 1.294E-2 2 16
29 C0086132 Depressive Symptoms DisGeNET Curated 1.931E-5 4.502E-4 3.194E-3 1.306E-2 3 135
30 C0030193 Pain DisGeNET Curated 2.320E-5 5.227E-4 3.708E-3 1.568E-2 4 472
31 C0040479 Torsades de Pointes DisGeNET Curated 2.439E-5 5.265E-4 3.735E-3 1.649E-2 2 18
32 C0042963 Vomiting DisGeNET Curated 2.492E-5 5.265E-4 3.735E-3 1.685E-2 3 147
33 C1443924 Severe diarrhea DisGeNET BeFree 2.726E-5 5.419E-4 3.844E-3 1.842E-2 2 19
34 C0600142 Hot flushes DisGeNET BeFree 2.726E-5 5.419E-4 3.844E-3 1.842E-2 2 19
35 C0268307 Conjugated hyperbilirubinemia DisGeNET Curated 3.680E-5 7.107E-4 5.042E-3 2.487E-2 2 22
36 C1319315 Adenocarcinoma of large intestine DisGeNET BeFree 4.416E-5 8.291E-4 5.882E-3 2.985E-2 3 178
37 C0032969 Pregnancy in Diabetics DisGeNET BeFree 4.776E-5 8.496E-4 6.027E-3 3.228E-2 2 25
38 C0085602 Polydipsia DisGeNET Curated 4.776E-5 8.496E-4 6.027E-3 3.228E-2 2 25
39 C0024620 Primary malignant neoplasm of liver DisGeNET BeFree 5.585E-5 9.681E-4 6.868E-3 3.776E-2 2 27
40 C0553665 Skin endocrine disorder DisGeNET BeFree 6.157E-5 1.041E-3 7.382E-3 4.162E-2 3 199
41 C0268312 Progressive intrahepatic cholestasis (disorder) DisGeNET Curated 6.458E-5 1.065E-3 7.554E-3 4.366E-2 2 29
42 C4277682 Chemical and Drug Induced Liver Injury DisGeNET Curated 7.433E-5 1.196E-3 8.487E-3
5.025E-2
 3 212
43 C0410207 Tubular Aggregate Myopathy DisGeNET Curated 8.392E-5 1.319E-3 9.359E-3
5.673E-2
 2 33
44 C0206624 Hepatoblastoma DisGeNET Curated 9.349E-5 1.436E-3 1.019E-2
6.320E-2
 3 229
45 C0020443 Hypercholesterolemia DisGeNET Curated 9.593E-5 1.441E-3 1.022E-2
6.485E-2
 3 231
46 C0020625 Hyponatremia DisGeNET Curated 1.116E-4 1.605E-3 1.139E-2
7.545E-2
 2 38
47 C0027497 Nausea DisGeNET Curated 1.116E-4 1.605E-3 1.139E-2
7.545E-2
 2 38
48 C0280220 stage, ovarian epithelial cancer DisGeNET BeFree 1.176E-4 1.657E-3 1.175E-2
7.951E-2
 2 39
49 C0521585 Gastrointestinal mucositis DisGeNET BeFree 1.238E-4 1.708E-3 1.212E-2
8.368E-2
 2 40
50 C0685938 Malignant neoplasm of gastrointestinal tract DisGeNET BeFree 1.286E-4 1.739E-3 1.234E-2
8.695E-2
 3 255
Show 45 more annotations