Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc36_11, positive side

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1: GO: Molecular Function [Display Chart] 10 input genes in category / 32 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005516 calmodulin binding 2.084E-6 6.670E-5 2.707E-4 6.670E-5 4 190
2 GO:0030165 PDZ domain binding 2.583E-5 4.132E-4 1.677E-3 8.264E-4 3 114
3 GO:0003779 actin binding 4.425E-5 4.720E-4 1.916E-3 1.416E-3 4 412
4 GO:0050998 nitric-oxide synthase binding 5.936E-5 4.749E-4 1.927E-3 1.900E-3 2 22
5 GO:0017080 sodium channel regulator activity 1.437E-4 9.195E-4 3.732E-3 4.598E-3 2 34
6 GO:0051117 ATPase binding 9.437E-4 5.033E-3 2.043E-2 3.020E-2 2 87
7 GO:0004517 nitric-oxide synthase activity 1.607E-3 7.346E-3 2.981E-2
5.142E-2
 1 3
8 GO:0044325 ion channel binding 1.995E-3 7.616E-3 3.091E-2
6.385E-2
 2 127
9 GO:0034617 tetrahydrobiopterin binding 2.142E-3 7.616E-3 3.091E-2
6.854E-2
 1 4
10 GO:0016247 channel regulator activity 2.384E-3 7.628E-3 3.096E-2
7.628E-2
 2 139
11 GO:0046870 cadmium ion binding 3.211E-3 9.342E-3 3.792E-2
1.028E-1
 1 6
12 GO:0034618 arginine binding 3.746E-3 9.989E-3 4.054E-2
1.199E-1
 1 7
13 GO:0002162 dystroglycan binding 5.347E-3 1.316E-2
5.342E-2
1.711E-1
 1 10
14 GO:0017166 vinculin binding 6.413E-3 1.466E-2
5.950E-2
2.052E-1
 1 12
15 GO:0010181 FMN binding 8.011E-3 1.709E-2
6.936E-2
2.564E-1
 1 15
16 GO:0008307 structural constituent of muscle 2.176E-2 4.195E-2
1.703E-1
6.963E-1
 1 41
17 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2.229E-2 4.195E-2
1.703E-1
7.131E-1
 1 42
18 GO:0050661 NADP binding 2.543E-2 4.521E-2
1.835E-1
8.138E-1
 1 48
19 GO:0097110 scaffold protein binding 2.909E-2 4.900E-2
1.989E-1
9.310E-1
 1 55
Show 14 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 390 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006936 muscle contraction 3.268E-9 1.275E-6 8.342E-6 1.275E-6 6 348
2 GO:0003012 muscle system process 1.159E-8 1.670E-6 1.093E-5 4.522E-6 6 430
3 GO:0018119 peptidyl-cysteine S-nitrosylation 1.285E-8 1.670E-6 1.093E-5 5.013E-6 3 11
4 GO:0017014 protein nitrosylation 1.713E-8 1.670E-6 1.093E-5 6.682E-6 3 12
5 GO:0060047 heart contraction 8.277E-8 5.678E-6 3.716E-5 3.228E-5 5 276
6 GO:0003015 heart process 8.736E-8 5.678E-6 3.716E-5 3.407E-5 5 279
7 GO:0018198 peptidyl-cysteine modification 1.786E-7 9.948E-6 6.511E-5 6.964E-5 3 25
8 GO:0007517 muscle organ development 5.566E-7 2.324E-5 1.521E-4 2.171E-4 5 405
9 GO:0042692 muscle cell differentiation 6.058E-7 2.324E-5 1.521E-4 2.363E-4 5 412
10 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation 6.227E-7 2.324E-5 1.521E-4 2.428E-4 2 3
11 GO:0006941 striated muscle contraction 6.556E-7 2.324E-5 1.521E-4 2.557E-4 4 161
12 GO:0055001 muscle cell development 1.047E-6 3.403E-5 2.227E-4 4.083E-4 4 181
13 GO:1902305 regulation of sodium ion transmembrane transport 1.806E-6 5.419E-5 3.547E-4 7.045E-4 3 53
14 GO:2000169 regulation of peptidyl-cysteine S-nitrosylation 2.075E-6 5.779E-5 3.782E-4 8.091E-4 2 5
15 GO:0002028 regulation of sodium ion transport 8.390E-6 2.181E-4 1.428E-3 3.272E-3 3 88
16 GO:0060048 cardiac muscle contraction 2.239E-5 5.402E-4 3.536E-3 8.731E-3 3 122
17 GO:0014706 striated muscle tissue development 2.355E-5 5.402E-4 3.536E-3 9.184E-3 4 397
18 GO:0060537 muscle tissue development 2.803E-5 5.817E-4 3.807E-3 1.093E-2 4 415
19 GO:0035725 sodium ion transmembrane transport 2.834E-5 5.817E-4 3.807E-3 1.105E-2 3 132
20 GO:1902307 positive regulation of sodium ion transmembrane transport 3.927E-5 7.657E-4 5.012E-3 1.531E-2 2 20
21 GO:0046716 muscle cell cellular homeostasis 4.339E-5 8.058E-4 5.274E-3 1.692E-2 2 21
22 GO:0033137 negative regulation of peptidyl-serine phosphorylation 6.707E-5 1.189E-3 7.781E-3 2.616E-2 2 26
23 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 7.242E-5 1.228E-3 8.036E-3 2.824E-2 2 27
24 GO:0048738 cardiac muscle tissue development 1.211E-4 1.968E-3 1.288E-2 4.723E-2 3 215
25 GO:0006814 sodium ion transport 1.262E-4 1.968E-3 1.288E-2 4.920E-2 3 218
26 GO:1904062 regulation of cation transmembrane transport 1.636E-4 2.453E-3 1.606E-2
6.379E-2
 3 238
27 GO:0008016 regulation of heart contraction 1.718E-4 2.482E-3 1.624E-2
6.701E-2
 3 242
28 GO:0010765 positive regulation of sodium ion transport 1.943E-4 2.707E-3 1.772E-2
7.579E-2
 2 44
29 GO:0086001 cardiac muscle cell action potential 2.719E-4 3.656E-3 2.393E-2
1.060E-1
 2 52
30 GO:0051146 striated muscle cell differentiation 2.899E-4 3.769E-3 2.466E-2
1.131E-1
 3 289
31 GO:0048747 muscle fiber development 4.251E-4 5.059E-3 3.311E-2
1.658E-1
 2 65
32 GO:1903522 regulation of blood circulation 4.432E-4 5.059E-3 3.311E-2
1.729E-1
 3 334
33 GO:0003116 regulation of vasoconstriction by norepinephrine 4.833E-4 5.059E-3 3.311E-2
1.885E-1
 1 1
34 GO:0016203 muscle attachment 4.833E-4 5.059E-3 3.311E-2
1.885E-1
 1 1
35 GO:0021629 olfactory nerve structural organization 4.833E-4 5.059E-3 3.311E-2
1.885E-1
 1 1
36 GO:0003117 regulation of vasoconstriction by circulating norepinephrine 4.833E-4 5.059E-3 3.311E-2
1.885E-1
 1 1
37 GO:0021627 olfactory nerve morphogenesis 4.833E-4 5.059E-3 3.311E-2
1.885E-1
 1 1
38 GO:0055117 regulation of cardiac muscle contraction 4.929E-4 5.059E-3 3.311E-2
1.922E-1
 2 70
39 GO:1901019 regulation of calcium ion transmembrane transporter activity 5.507E-4 5.507E-3 3.604E-2
2.148E-1
 2 74
40 GO:0010959 regulation of metal ion transport 6.169E-4 6.014E-3 3.936E-2
2.406E-1
 3 374
41 GO:0019229 regulation of vasoconstriction 6.595E-4 6.273E-3 4.105E-2
2.572E-1
 2 81
42 GO:0006942 regulation of striated muscle contraction 7.259E-4 6.584E-3 4.309E-2
2.831E-1
 2 85
43 GO:0050848 regulation of calcium-mediated signaling 7.259E-4 6.584E-3 4.309E-2
2.831E-1
 2 85
44 GO:0051279 regulation of release of sequestered calcium ion into cytosol 7.603E-4 6.739E-3 4.410E-2
2.965E-1
 2 87
45 GO:0002027 regulation of heart rate 9.633E-4 8.193E-3
5.362E-2
3.757E-1
 2 98
46 GO:0060857 establishment of glial blood-brain barrier 9.663E-4 8.193E-3
5.362E-2
3.769E-1
 1 2
47 GO:2001257 regulation of cation channel activity 1.003E-3 8.301E-3
5.433E-2
3.911E-1
 2 100
48 GO:0042310 vasoconstriction 1.043E-3 8.301E-3
5.433E-2
4.067E-1
 2 102
49 GO:0070252 actin-mediated cell contraction 1.043E-3 8.301E-3
5.433E-2
4.067E-1
 2 102
50 GO:0034765 regulation of ion transmembrane transport 1.091E-3 8.506E-3
5.567E-2
4.253E-1
 3 455
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 11 input genes in category / 67 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0090665 glycoprotein complex 2.991E-26 1.002E-24 4.799E-24 2.004E-24 9 22
2 GO:0016010 dystrophin-associated glycoprotein complex 2.991E-26 1.002E-24 4.799E-24 2.004E-24 9 22
3 GO:0042383 sarcolemma 5.569E-18 1.244E-16 5.956E-16 3.731E-16 9 152
4 GO:0016012 sarcoglycan complex 8.997E-13 1.507E-11 7.218E-11 6.028E-11 4 6
5 GO:0016011 dystroglycan complex 2.099E-12 2.812E-11 1.347E-10 1.406E-10 4 7
6 GO:0016013 syntrophin complex 1.816E-6 2.027E-5 9.710E-5 1.216E-4 2 4
7 GO:0016328 lateral plasma membrane 4.106E-4 3.930E-3 1.882E-2 2.751E-2 2 53
8 GO:0016014 dystrobrevin complex 5.771E-4 4.296E-3 2.058E-2 3.867E-2 1 1
9 GO:1990425 ryanodine receptor complex 5.771E-4 4.296E-3 2.058E-2 3.867E-2 1 1
10 GO:0045121 membrane raft 8.561E-4 5.215E-3 2.497E-2
5.736E-2
 3 343
11 GO:0098857 membrane microdomain 8.561E-4 5.215E-3 2.497E-2
5.736E-2
 3 343
12 GO:0030055 cell-substrate junction 1.364E-3 7.617E-3 3.648E-2
9.140E-2
 3 403
13 GO:0098794 postsynapse 1.861E-3 9.590E-3 4.593E-2
1.247E-1
 3 449
14 GO:0030018 Z disc 2.049E-3 9.806E-3 4.696E-2
1.373E-1
 2 119
15 GO:0031674 I band 2.626E-3 1.173E-2
5.618E-2
1.760E-1
 2 135
16 GO:0030017 sarcomere 5.552E-3 2.325E-2
1.113E-1
3.720E-1
 2 198
17 GO:0044449 contractile fiber part 6.514E-3 2.508E-2
1.201E-1
4.364E-1
 2 215
18 GO:0030016 myofibril 6.810E-3 2.508E-2
1.201E-1
4.563E-1
 2 220
19 GO:0045211 postsynaptic membrane 7.113E-3 2.508E-2
1.201E-1
4.765E-1
 2 225
20 GO:0043292 contractile fiber 7.673E-3 2.570E-2
1.231E-1
5.141E-1
 2 234
21 GO:0005766 primary lysosome 1.034E-2 3.149E-2
1.508E-1
6.929E-1
 1 18
22 GO:0042582 azurophil granule 1.034E-2 3.149E-2
1.508E-1
6.929E-1
 1 18
23 GO:0031527 filopodium membrane 1.091E-2 3.179E-2
1.523E-1
7.312E-1
 1 19
24 GO:0043034 costamere 1.206E-2 3.271E-2
1.567E-1
8.077E-1
 1 21
25 GO:0097060 synaptic membrane 1.221E-2 3.271E-2
1.567E-1
8.178E-1
 2 298
Show 20 more annotations

4: Human Phenotype [Display Chart] 7 input genes in category / 319 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001430 Abnormality of the calf musculature 6.908E-8 2.204E-5 1.398E-4 2.204E-5 4 33
2 HP:0003707 Calf muscle pseudohypertrophy 3.308E-7 5.276E-5 3.347E-4 1.055E-4 3 11
3 HP:0001437 Abnormality of the musculature of the lower limbs 4.779E-6 5.082E-4 3.224E-3 1.524E-3 4 93
4 HP:0003797 Limb-girdle muscle atrophy 2.096E-5 1.672E-3 1.061E-2 6.687E-3 3 41
5 HP:0003560 Muscular dystrophy 9.436E-5 6.020E-3 3.819E-2 3.010E-2 4 197
6 HP:0003713 Muscle fiber necrosis 1.711E-4 6.308E-3 4.002E-2
5.457E-2
 2 14
7 HP:0002981 Abnormality of the calf 1.851E-4 6.308E-3 4.002E-2
5.905E-2
 4 234
8 HP:0003236 Elevated serum creatine phosphokinase 1.913E-4 6.308E-3 4.002E-2
6.104E-2
 4 236
9 HP:0040081 Abnormal levels of creatine kinase in blood 1.913E-4 6.308E-3 4.002E-2
6.104E-2
 4 236
10 HP:0011021 Abnormality of circulating enzyme level 1.977E-4 6.308E-3 4.002E-2
6.308E-2
 4 238
11 HP:0008981 Calf muscle hypertrophy 3.928E-4 1.139E-2
7.227E-2
1.253E-1
 2 21
12 HP:0008968 Muscle hypertrophy of the lower extremities 4.318E-4 1.148E-2
7.282E-2
1.378E-1
 2 22
13 HP:0009127 Abnormality of the musculature of the limbs 6.152E-4 1.510E-2
9.577E-2
1.962E-1
 4 319
14 HP:0006785 Limb-girdle muscular dystrophy 9.206E-4 2.098E-2
1.331E-1
2.937E-1
 2 32
15 HP:0010876 Abnormality of circulating protein level 2.043E-3 4.127E-2
2.618E-1
6.517E-1
 4 437
16 HP:0003391 Gowers sign 2.070E-3 4.127E-2
2.618E-1
6.603E-1
 2 48
17 HP:0011664 Left ventricular noncompaction cardiomyopathy 2.972E-3 4.747E-2
3.012E-1
9.482E-1
 1 2
18 HP:0010532 Paroxysmal vertigo 2.972E-3 4.747E-2
3.012E-1
9.482E-1
 1 2
19 HP:0009900 Unilateral deafness 2.972E-3 4.747E-2
3.012E-1
9.482E-1
 1 2
20 HP:0003202 Skeletal muscle atrophy 2.976E-3 4.747E-2
3.012E-1
9.495E-1
 4 483
Show 15 more annotations

5: Mouse Phenotype [Display Chart] 9 input genes in category / 605 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000752 dystrophic muscle 2.968E-13 1.795E-10 1.254E-9 1.795E-10 6 43
2 MP:0010106 abnormal circulating pyruvate kinase level 4.541E-10 1.374E-7 9.592E-7 2.747E-7 3 3
3 MP:0003141 cardiac fibrosis 4.095E-9 8.258E-7 5.767E-6 2.477E-6 6 202
4 MP:0010632 cardiac muscle necrosis 1.917E-8 2.900E-6 2.025E-5 1.160E-5 4 38
5 MP:0003852 skeletal muscle necrosis 3.518E-8 4.256E-6 2.972E-5 2.128E-5 4 44
6 MP:0003199 calcified muscle 5.432E-8 5.477E-6 3.825E-5 3.286E-5 3 10
7 MP:0004121 abnormal sarcolemma morphology 5.138E-7 4.441E-5 3.101E-4 3.109E-4 3 20
8 MP:0000759 abnormal skeletal muscle morphology 7.813E-7 5.909E-5 4.126E-4 4.727E-4 6 487
9 MP:0001053 abnormal neuromuscular synapse morphology 9.166E-7 6.162E-5 4.303E-4 5.546E-4 4 98
10 MP:0001051 abnormal somatic motor system morphology 1.120E-6 6.774E-5 4.731E-4 6.774E-4 4 103
11 MP:0006085 myocardial necrosis 1.471E-6 8.093E-5 5.651E-4 8.902E-4 3 28
12 MP:0010090 increased circulating creatine kinase level 3.772E-6 1.901E-4 1.328E-3 2.282E-3 3 38
13 MP:0020280 increased creatine kinase level 4.085E-6 1.901E-4 1.328E-3 2.471E-3 3 39
14 MP:0010089 abnormal circulating creatine kinase level 4.761E-6 1.920E-4 1.341E-3 2.880E-3 3 41
15 MP:0002841 impaired skeletal muscle contractility 4.761E-6 1.920E-4 1.341E-3 2.880E-3 3 41
16 MP:0020279 abnormal creatine kinase level 5.125E-6 1.938E-4 1.353E-3 3.101E-3 3 42
17 MP:0003358 abnormal hypaxial muscle morphology 6.676E-6 2.376E-4 1.659E-3 4.039E-3 4 161
18 MP:0005330 cardiomyopathy 7.360E-6 2.474E-4 1.728E-3 4.453E-3 4 165
19 MP:0004233 abnormal muscle weight 9.823E-6 3.128E-4 2.184E-3 5.943E-3 3 52
20 MP:0004087 abnormal muscle fiber morphology 1.820E-5 5.309E-4 3.707E-3 1.101E-2 5 459
21 MP:0009538 abnormal synapse morphology 1.913E-5 5.309E-4 3.707E-3 1.157E-2 4 210
22 MP:0002953 thick ventricular wall 1.930E-5 5.309E-4 3.707E-3 1.168E-2 3 65
23 MP:0003084 abnormal skeletal muscle fiber morphology 2.467E-5 6.351E-4 4.435E-3 1.492E-2 4 224
24 MP:0000749 muscle degeneration 2.519E-5 6.351E-4 4.435E-3 1.524E-2 3 71
25 MP:0009461 skeletal muscle hypertrophy 3.011E-5 7.287E-4 5.089E-3 1.822E-2 2 10
26 MP:0003397 increased muscle weight 4.412E-5 1.027E-3 7.170E-3 2.669E-2 2 12
27 MP:0003851 skeletal muscle interstitial fibrosis 5.212E-5 1.147E-3 8.010E-3 3.153E-2 2 13
28 MP:0009404 centrally nucleated skeletal muscle fibers 5.309E-5 1.147E-3 8.010E-3 3.212E-2 3 91
29 MP:0009458 abnormal skeletal muscle size 8.142E-5 1.698E-3 1.186E-2 4.926E-2 3 105
30 MP:0003646 muscle fatigue 1.266E-4 2.470E-3 1.725E-2
7.657E-2
 2 20
31 MP:0003398 increased skeletal muscle size 1.266E-4 2.470E-3 1.725E-2
7.657E-2
 2 20
32 MP:0003083 abnormal tibialis anterior morphology 1.683E-4 3.182E-3 2.222E-2
1.018E-1
 2 23
33 MP:0010053 decreased grip strength 1.771E-4 3.246E-3 2.267E-2
1.071E-1
 4 371
34 MP:0009414 skeletal muscle fiber necrosis 2.159E-4 3.842E-3 2.683E-2
1.306E-1
 2 26
35 MP:0010239 decreased skeletal muscle weight 2.331E-4 4.029E-3 2.813E-2
1.410E-1
 2 27
36 MP:0009412 skeletal muscle fiber degeneration 2.509E-4 4.216E-3 2.944E-2
1.518E-1
 2 28
37 MP:0004818 increased skeletal muscle mass 2.693E-4 4.404E-3 3.076E-2
1.630E-1
 2 29
38 MP:0004510 myositis 3.082E-4 4.907E-3 3.427E-2
1.865E-1
 2 31
39 MP:0004817 abnormal skeletal muscle mass 3.166E-4 4.911E-3 3.430E-2
1.915E-1
 3 166
40 MP:0010237 abnormal skeletal muscle weight 3.286E-4 4.970E-3 3.471E-2
1.988E-1
 2 32
41 MP:0004835 abnormal miniature endplate potential 3.497E-4 5.063E-3 3.536E-2
2.115E-1
 2 33
42 MP:0005166 decreased susceptibility to injury 3.515E-4 5.063E-3 3.536E-2
2.126E-1
 3 172
43 MP:0000748 progressive muscle weakness 4.402E-4 6.194E-3 4.326E-2
2.663E-1
 2 37
44 MP:0004566 myocardial fiber degeneration 4.645E-4 6.245E-3 4.361E-2
2.810E-1
 2 38
45 MP:0004996 abnormal CNS synapse formation 4.645E-4 6.245E-3 4.361E-2
2.810E-1
 2 38
46 MP:0009399 increased skeletal muscle fiber size 4.894E-4 6.253E-3 4.367E-2
2.961E-1
 2 39
47 MP:0001515 abnormal grip strength 4.922E-4 6.253E-3 4.367E-2
2.978E-1
 4 484
48 MP:0005329 abnormal myocardium layer morphology 4.961E-4 6.253E-3 4.367E-2
3.002E-1
 4 485
49 MP:0020135 abnormal heart ventricle wall thickness 5.313E-4 6.295E-3 4.396E-2
3.214E-1
 3 198
50 MP:0010545 abnormal heart layer morphology 5.322E-4 6.295E-3 4.396E-2
3.220E-1
 4 494
Show 45 more annotations

6: Domain [Display Chart] 11 input genes in category / 77 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF04790 Sarcoglycan 1 Pfam 6.021E-10 2.318E-8 1.142E-7 4.636E-8 3 4
2 IPR006875 Sarcoglycan InterPro 6.021E-10 2.318E-8 1.142E-7 4.636E-8 3 4
3 IPR015482 Syntrophin InterPro 1.505E-9 3.309E-8 1.631E-7 1.159E-7 3 5
4 IPR015153 EF-hand dom typ1 InterPro 3.009E-9 3.309E-8 1.631E-7 2.317E-7 3 6
5 PF09069 EF-hand 3 Pfam 3.009E-9 3.309E-8 1.631E-7 2.317E-7 3 6
6 PF09068 EF-hand 2 Pfam 3.009E-9 3.309E-8 1.631E-7 2.317E-7 3 6
7 IPR015154 EF-hand dom typ2 InterPro 3.009E-9 3.309E-8 1.631E-7 2.317E-7 3 6
8 PS50135 ZF ZZ 2 PROSITE 1.223E-7 9.314E-7 4.590E-6 9.415E-6 3 18
9 PS01357 ZF ZZ 1 PROSITE 1.223E-7 9.314E-7 4.590E-6 9.415E-6 3 18
10 PF00569 ZZ Pfam 1.223E-7 9.314E-7 4.590E-6 9.415E-6 3 18
11 SM00291 ZnF ZZ SMART 1.452E-7 9.314E-7 4.590E-6 1.118E-5 3 19
12 IPR000433 Znf ZZ InterPro 1.452E-7 9.314E-7 4.590E-6 1.118E-5 3 19
13 IPR017432 Distrobrevin InterPro 3.134E-7 1.856E-6 9.147E-6 2.413E-5 2 2
14 PF00595 PDZ Pfam 9.738E-7 5.356E-6 2.639E-5 7.498E-5 4 141
15 SM00228 PDZ SMART 1.182E-6 5.625E-6 2.772E-5 9.101E-5 4 148
16 2.30.42.10 - Gene3D 1.247E-6 5.625E-6 2.772E-5 9.602E-5 4 150
17 PS50106 PDZ PROSITE 1.281E-6 5.625E-6 2.772E-5 9.861E-5 4 151
18 IPR001478 PDZ InterPro 1.315E-6 5.625E-6 2.772E-5 1.012E-4 4 152
19 PF00169 PH Pfam 2.802E-4 1.135E-3 5.595E-3 2.157E-2 3 230
20 1.10.238.10 - Gene3D 4.060E-4 1.507E-3 7.426E-3 3.126E-2 3 261
21 SM00233 PH SMART 4.934E-4 1.507E-3 7.426E-3 3.799E-2 3 279
22 PS50003 PH DOMAIN PROSITE 4.986E-4 1.507E-3 7.426E-3 3.839E-2 3 280
23 IPR001849 PH domain InterPro 5.038E-4 1.507E-3 7.426E-3 3.879E-2 3 281
24 IPR011992 EF-hand-dom pair InterPro 5.359E-4 1.507E-3 7.426E-3 4.126E-2 3 287
25 IPR028658 Alpha-SG InterPro 5.871E-4 1.507E-3 7.426E-3 4.521E-2 1 1
26 IPR027660 SGCG InterPro 5.871E-4 1.507E-3 7.426E-3 4.521E-2 1 1
27 IPR027662 Sgcz InterPro 5.871E-4 1.507E-3 7.426E-3 4.521E-2 1 1
28 IPR027659 Sgcb InterPro 5.871E-4 1.507E-3 7.426E-3 4.521E-2 1 1
29 IPR028550 SNTB2 InterPro 5.871E-4 1.507E-3 7.426E-3 4.521E-2 1 1
30 IPR028552 SNTA1 InterPro 5.871E-4 1.507E-3 7.426E-3 4.521E-2 1 1
31 IPR016344 Dystrophin InterPro 1.174E-3 2.739E-3 1.350E-2
9.039E-2
 1 2
32 IPR008908 Sarcoglycan alpha/epsilon InterPro 1.174E-3 2.739E-3 1.350E-2
9.039E-2
 1 2
33 PF05510 Sarcoglycan 2 Pfam 1.174E-3 2.739E-3 1.350E-2
9.039E-2
 1 2
34 IPR011993 PH dom-like InterPro 1.693E-3 3.306E-3 1.629E-2
1.303E-1
 3 427
35 PF02898 NO synthase Pfam 1.760E-3 3.306E-3 1.629E-2
1.356E-1
 1 3
36 IPR006644 Cadg InterPro 1.760E-3 3.306E-3 1.629E-2
1.356E-1
 1 3
37 PS60001 NOS PROSITE 1.760E-3 3.306E-3 1.629E-2
1.356E-1
 1 3
38 SM00736 CADG SMART 1.760E-3 3.306E-3 1.629E-2
1.356E-1
 1 3
39 IPR012144 NOS euk InterPro 1.760E-3 3.306E-3 1.629E-2
1.356E-1
 1 3
40 IPR004030 NOS N InterPro 1.760E-3 3.306E-3 1.629E-2
1.356E-1
 1 3
41 3.90.340.10 - Gene3D 1.760E-3 3.306E-3 1.629E-2
1.356E-1
 1 3
42 IPR003097 FAD-binding 1 InterPro 3.518E-3 6.020E-3 2.966E-2
2.709E-1
 1 6
43 PF00667 FAD binding 1 Pfam 3.518E-3 6.020E-3 2.966E-2
2.709E-1
 1 6
44 1.20.990.10 - Gene3D 3.518E-3 6.020E-3 2.966E-2
2.709E-1
 1 6
45 IPR023173 NADPH Cyt P450 Rdtase dom3 InterPro 3.518E-3 6.020E-3 2.966E-2
2.709E-1
 1 6
46 IPR008254 Flavodoxin/NO synth InterPro 4.688E-3 7.367E-3 3.630E-2
3.610E-1
 1 8
47 IPR001094 Flavdoxin-like InterPro 4.688E-3 7.367E-3 3.630E-2
3.610E-1
 1 8
48 PF00258 Flavodoxin 1 Pfam 4.688E-3 7.367E-3 3.630E-2
3.610E-1
 1 8
49 PS50902 FLAVODOXIN LIKE PROSITE 4.688E-3 7.367E-3 3.630E-2
3.610E-1
 1 8
50 IPR001709 Flavoprot Pyr Nucl cyt Rdtase InterPro 5.857E-3 8.673E-3 4.274E-2
4.510E-1
 1 10
Show 45 more annotations

7: Pathway [Display Chart] 8 input genes in category / 44 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 125138 Viral myocarditis BioSystems: KEGG 3.139E-8 1.381E-6 6.040E-6 1.381E-6 4 59
2 117293 Arrhythmogenic right ventricular cardiomyopathy (ARVC) BioSystems: KEGG 7.072E-8 1.556E-6 6.804E-6 3.112E-6 4 72
3 114229 Hypertrophic cardiomyopathy (HCM) BioSystems: KEGG 1.260E-7 1.848E-6 8.079E-6 5.543E-6 4 83
4 121494 Dilated cardiomyopathy BioSystems: KEGG 1.748E-7 1.923E-6 8.410E-6 7.693E-6 4 90
5 SMP00327 Phenytoin (Antiarrhythmic) Pathway SMPDB 1.339E-6 4.209E-6 1.841E-5 5.893E-5 3 37
6 SMP00331 Flecainide Pathway SMPDB 1.339E-6 4.209E-6 1.841E-5 5.893E-5 3 37
7 SMP00324 Procainamide (Antiarrhythmic) Pathway SMPDB 1.339E-6 4.209E-6 1.841E-5 5.893E-5 3 37
8 SMP00329 Mexiletine Pathway SMPDB 1.339E-6 4.209E-6 1.841E-5 5.893E-5 3 37
9 SMP00330 Tocainide Pathway SMPDB 1.339E-6 4.209E-6 1.841E-5 5.893E-5 3 37
10 SMP00328 Lidocaine (Antiarrhythmic) Pathway SMPDB 1.339E-6 4.209E-6 1.841E-5 5.893E-5 3 37
11 SMP00325 Disopyramide Pathway SMPDB 1.339E-6 4.209E-6 1.841E-5 5.893E-5 3 37
12 SMP00323 Quinidine Pathway SMPDB 1.339E-6 4.209E-6 1.841E-5 5.893E-5 3 37
13 SMP00332 Ibutilide Pathway SMPDB 1.339E-6 4.209E-6 1.841E-5 5.893E-5 3 37
14 SMP00326 Fosphenytoin (Antiarrhythmic) Pathway SMPDB 1.339E-6 4.209E-6 1.841E-5 5.893E-5 3 37
15 SMP00359 Diltiazem Pathway SMPDB 5.013E-6 1.379E-5 6.029E-5 2.206E-4 3 57
16 SMP00375 Verapamil Pathway SMPDB 5.013E-6 1.379E-5 6.029E-5 2.206E-4 3 57
17 703092 citrulline-nitric oxide cycle BioSystems: BIOCYC 3.209E-3 8.306E-3 3.632E-2
1.412E-1
 1 5
18 1269868 Muscle contraction BioSystems: REACTOME 7.010E-3 1.632E-2
7.137E-2
3.084E-1
 2 204
19 138043 Signaling mediated by p38-gamma and p38-delta BioSystems: Pathway Interaction Database 7.048E-3 1.632E-2
7.137E-2
3.101E-1
 1 11
20 PW:0000018 Parkinson disease Pathway Ontology 1.024E-2 2.252E-2
9.849E-2
4.505E-1
 1 16
21 SMP00207 Prolidase Deficiency(PD) SMPDB 1.087E-2 2.279E-2
9.963E-2
4.785E-1
 1 17
22 SMP00020 Arginine and Proline Metabolism SMPDB 1.151E-2 2.302E-2
1.007E-1
5.065E-1
 1 18
23 PW:0000050 arginine and proline metabolic Pathway Ontology 1.342E-2 2.460E-2
1.076E-1
5.904E-1
 1 21
24 82943 Arginine biosynthesis BioSystems: KEGG 1.342E-2 2.460E-2
1.076E-1
5.904E-1
 1 21
25 M11650 Nitric Oxide Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.405E-2 2.473E-2
1.082E-1
6.183E-1
 1 22
26 1269343 Nitric oxide stimulates guanylate cyclase BioSystems: REACTOME 1.532E-2 2.593E-2
1.134E-1
6.742E-1
 1 24
27 1269138 ROS, RNS production in phagocytes BioSystems: REACTOME 2.101E-2 3.401E-2
1.487E-1
9.247E-1
 1 33
28 1269869 Striated Muscle Contraction BioSystems: REACTOME 2.165E-2 3.401E-2
1.487E-1
9.524E-1
 1 34
29 M6220 Agrin in Postsynaptic Differentiation MSigDB C2 BIOCARTA (v6.0) 2.291E-2 3.475E-2
1.520E-1
1.000E0
 1 36
30 MAP00330 Arginine and proline metabolism MAP00330 Arginine and proline metabolism GenMAPP 2.417E-2 3.544E-2
1.550E-1
1.000E0
 1 38
31 1270254 Non-integrin membrane-ECM interactions BioSystems: REACTOME 2.919E-2 4.143E-2
1.811E-1
1.000E0
 1 46
32 82957 Arginine and proline metabolism BioSystems: KEGG 3.169E-2 4.309E-2
1.884E-1
1.000E0
 1 50
33 83099 Amyotrophic lateral sclerosis (ALS) BioSystems: KEGG 3.231E-2 4.309E-2
1.884E-1
1.000E0
 1 51
34 1339121 Ion homeostasis BioSystems: REACTOME 3.543E-2 4.585E-2
2.005E-1
1.000E0
 1 56
35 83086 Long-term depression BioSystems: KEGG 3.792E-2 4.767E-2
2.085E-1
1.000E0
 1 60
Show 30 more annotations

8: Pubmed [Display Chart] 11 input genes in category / 3022 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 22937058 Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins. Pubmed 4.414E-27 1.334E-23 1.146E-22 1.334E-23 8 14
2 10995443 Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin. Pubmed 4.631E-24 6.997E-21 6.011E-20 1.399E-20 7 11
3 9214383 Differential association of syntrophin pairs with the dystrophin complex. Pubmed 6.824E-19 6.874E-16 5.905E-15 2.062E-15 5 5
4 12189167 Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy. Pubmed 4.094E-18 1.767E-15 1.518E-14 1.237E-14 5 6
5 8576247 The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. Pubmed 4.094E-18 1.767E-15 1.518E-14 1.237E-14 5 6
6 7547961 Interactions between dystrophin glycoprotein complex proteins. Pubmed 4.094E-18 1.767E-15 1.518E-14 1.237E-14 5 6
7 10545507 Different dystrophin-like complexes are expressed in neurons and glia. Pubmed 4.094E-18 1.767E-15 1.518E-14 1.237E-14 5 6
8 10747910 Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells. Pubmed 1.433E-17 5.412E-15 4.649E-14 4.329E-14 5 7
9 18468998 Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. Pubmed 3.166E-17 1.063E-14 9.133E-14 9.568E-14 6 27
10 9412493 Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins. Pubmed 3.820E-17 1.154E-14 9.917E-14 1.154E-13 5 8
11 29790927 Syntrophin binds directly to multiple spectrin-like repeats in dystrophin and mediates binding of nNOS to repeats 16-17. Pubmed 3.723E-15 1.023E-12 8.786E-12 1.125E-11 4 4
12 15024025 Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Pubmed 7.920E-15 1.995E-12 1.714E-11 2.393E-11 5 19
13 16524571 Identification of functional domains in sarcoglycans essential for their interaction and plasma membrane targeting. Pubmed 1.861E-14 4.017E-12 3.451E-11 5.624E-11 4 5
14 18953332 Sarcolemma-localized nNOS is required to maintain activity after mild exercise. Pubmed 1.861E-14 4.017E-12 3.451E-11 5.624E-11 4 5
15 11352924 Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. Pubmed 1.302E-13 2.071E-11 1.780E-10 3.936E-10 4 7
16 17475492 Cytoplasmic gamma-actin expression in diverse animal models of muscular dystrophy. Pubmed 1.302E-13 2.071E-11 1.780E-10 3.936E-10 4 7
17 10767327 Biochemical evidence for association of dystrobrevin with the sarcoglycan-sarcospan complex as a basis for understanding sarcoglycanopathy. Pubmed 1.302E-13 2.071E-11 1.780E-10 3.936E-10 4 7
18 16306063 Common pathological mechanisms in mouse models for muscular dystrophies. Pubmed 1.302E-13 2.071E-11 1.780E-10 3.936E-10 4 7
19 1461282 Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle. Pubmed 1.302E-13 2.071E-11 1.780E-10 3.936E-10 4 7
20 11115849 Caveolin-3 deficiency causes muscle degeneration in mice. Pubmed 2.604E-13 3.935E-11 3.381E-10 7.870E-10 4 8
21 9419360 beta-dystrobrevin, a member of the dystrophin-related protein family. Pubmed 1.777E-11 1.648E-9 1.416E-8 5.370E-8 3 3
22 15954112 Sarcoglycanopathies and the risk of undetected deletion alleles in diagnosis. Pubmed 1.777E-11 1.648E-9 1.416E-8 5.370E-8 3 3
23 9182949 Differential expression of syntrophins and analysis of alternatively spliced dystrophin transcripts in the mouse brain. Pubmed 1.777E-11 1.648E-9 1.416E-8 5.370E-8 3 3
24 11069112 Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex. Pubmed 1.777E-11 1.648E-9 1.416E-8 5.370E-8 3 3
25 12206805 Dystrobrevin dynamics in muscle-cell signalling: a possible target for therapeutic intervention in Duchenne muscular dystrophy? Pubmed 1.777E-11 1.648E-9 1.416E-8 5.370E-8 3 3
26 18286648 The ABCA1 cholesterol transporter associates with one of two distinct dystrophin-based scaffolds in Schwann cells. Pubmed 1.777E-11 1.648E-9 1.416E-8 5.370E-8 3 3
27 16540561 Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin. Pubmed 1.777E-11 1.648E-9 1.416E-8 5.370E-8 3 3
28 11168526 Differential targeting of components of the dystrophin complex to the postsynaptic membrane. Pubmed 1.777E-11 1.648E-9 1.416E-8 5.370E-8 3 3
29 17382524 The 16 kDa subunit of vacuolar H+-ATPase is a novel sarcoglycan-interacting protein. Pubmed 1.777E-11 1.648E-9 1.416E-8 5.370E-8 3 3
30 15238508 Defects in neuromuscular junction structure in dystrophic muscle are corrected by expression of a NOS transgene in dystrophin-deficient muscles, but not in muscles lacking alpha- and beta1-syntrophins. Pubmed 1.777E-11 1.648E-9 1.416E-8 5.370E-8 3 3
31 8183929 Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24. Pubmed 1.777E-11 1.648E-9 1.416E-8 5.370E-8 3 3
32 9356463 Dystrobrevin and dystrophin: an interaction through coiled-coil motifs. Pubmed 1.777E-11 1.648E-9 1.416E-8 5.370E-8 3 3
33 21289070 DOT1L regulates dystrophin expression and is critical for cardiac function. Pubmed 1.799E-11 1.648E-9 1.416E-8 5.438E-8 4 20
34 7844150 Syntrophin binds to an alternatively spliced exon of dystrophin. Pubmed 7.107E-11 5.239E-9 4.501E-8 2.148E-7 3 4
35 14623885 DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes. Pubmed 7.107E-11 5.239E-9 4.501E-8 2.148E-7 3 4
36 18057022 Differential targeting of nNOS and AQP4 to dystrophin-deficient sarcolemma by membrane-directed alpha-dystrobrevin. Pubmed 7.107E-11 5.239E-9 4.501E-8 2.148E-7 3 4
37 18996010 Sarcoglycanopathies: can muscle immunoanalysis predict the genotype? Pubmed 7.107E-11 5.239E-9 4.501E-8 2.148E-7 3 4
38 16807372 Biglycan regulates the expression and sarcolemmal localization of dystrobrevin, syntrophin, and nNOS. Pubmed 7.107E-11 5.239E-9 4.501E-8 2.148E-7 3 4
39 12087055 Characterization of aquaporin-4 in muscle and muscular dystrophy. Pubmed 7.107E-11 5.239E-9 4.501E-8 2.148E-7 3 4
40 10678176 Disruption of the beta-sarcoglycan gene reveals pathogenetic complexity of limb-girdle muscular dystrophy type 2E. Pubmed 7.107E-11 5.239E-9 4.501E-8 2.148E-7 3 4
41 10448073 Developmental expression of sarcoglycan gene products in cultured myocytes. Pubmed 7.107E-11 5.239E-9 4.501E-8 2.148E-7 3 4
42 23418438 Distinctive serum miRNA profile in mouse models of striated muscular pathologies. Pubmed 1.777E-10 1.118E-8 9.609E-8 5.369E-7 3 5
43 9864373 Molecular organization of sarcoglycan complex in mouse myotubes in culture. Pubmed 1.777E-10 1.118E-8 9.609E-8 5.369E-7 3 5
44 24014171 Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology. Pubmed 1.777E-10 1.118E-8 9.609E-8 5.369E-7 3 5
45 16533813 Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. Pubmed 1.777E-10 1.118E-8 9.609E-8 5.369E-7 3 5
46 10993904 Expression of gamma -sarcoglycan in smooth muscle and its interaction with the smooth muscle sarcoglycan-sarcospan complex. Pubmed 1.777E-10 1.118E-8 9.609E-8 5.369E-7 3 5
47 22493004 Dp71 gene disruption alters the composition of the dystrophin-associated protein complex and neuronal nitric oxide synthase expression in the hypothalamic supraoptic and paraventricular nuclei. Pubmed 1.777E-10 1.118E-8 9.609E-8 5.369E-7 3 5
48 15310750 Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes. Pubmed 1.777E-10 1.118E-8 9.609E-8 5.369E-7 3 5
49 14688250 Myospryn is a novel binding partner for dysbindin in muscle. Pubmed 3.553E-10 2.147E-8 1.845E-7 1.074E-6 3 6
50 26060189 Serum proteomic profiling reveals fragments of MYOM3 as potential biomarkers for monitoring the outcome of therapeutic interventions in muscular dystrophies. Pubmed 3.553E-10 2.147E-8 1.845E-7 1.074E-6 3 6
Show 45 more annotations

9: Interaction [Display Chart] 11 input genes in category / 274 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:DMD DMD interactions 1.619E-27 4.436E-25 2.747E-24 4.436E-25 11 70
2 int:SNTG2 SNTG2 interactions 5.848E-16 8.012E-14 4.961E-13 1.602E-13 6 21
3 int:UTRN UTRN interactions 6.590E-15 6.019E-13 3.727E-12 1.806E-12 7 76
4 int:SGCB SGCB interactions 9.553E-14 6.544E-12 4.052E-11 2.618E-11 5 15
5 int:ADRA1D ADRA1D interactions 2.723E-13 1.244E-11 7.701E-11 7.462E-11 5 18
6 int:KCNJ12 KCNJ12 interactions 2.723E-13 1.244E-11 7.701E-11 7.462E-11 5 18
7 int:SNTA1 SNTA1 interactions 7.062E-12 2.764E-10 1.712E-9 1.935E-9 6 91
8 int:DTNA DTNA interactions 2.367E-11 8.086E-10 5.007E-9 6.485E-9 5 41
9 int:SPZ1 SPZ1 interactions 2.656E-11 8.086E-10 5.007E-9 7.278E-9 4 11
10 int:TNS2 TNS2 interactions 4.250E-11 1.165E-9 7.212E-9 1.165E-8 6 122
11 int:SGCD SGCD interactions 5.751E-11 1.433E-9 8.871E-9 1.576E-8 4 13
12 int:SGCA SGCA interactions 3.112E-10 7.105E-9 4.400E-8 8.526E-8 4 19
13 int:TNS1 TNS1 interactions 8.517E-10 1.795E-8 1.112E-7 2.334E-7 4 24
14 int:TNS3 TNS3 interactions 1.405E-9 2.751E-8 1.703E-7 3.851E-7 4 27
15 int:DGKZ DGKZ interactions 1.901E-9 3.472E-8 2.150E-7 5.208E-7 4 29
16 int:HMG20A HMG20A interactions 2.585E-9 4.427E-8 2.741E-7 7.084E-7 5 102
17 int:SGCG SGCG interactions 9.977E-9 1.608E-7 9.958E-7 2.734E-6 3 8
18 int:SCN4A SCN4A interactions 2.937E-8 4.470E-7 2.768E-6 8.047E-6 3 11
19 int:MLC1 MLC1 interactions 3.914E-8 5.363E-7 3.321E-6 1.073E-5 3 12
20 int:SNTG1 SNTG1 interactions 3.914E-8 5.363E-7 3.321E-6 1.073E-5 3 12
21 int:DAG1 DAG1 interactions 5.701E-8 7.438E-7 4.606E-6 1.562E-5 4 66
22 int:SGCZ SGCZ interactions 8.087E-8 1.007E-6 6.237E-6 2.216E-5 3 15
23 int:ADGRB1 ADGRB1 interactions 2.359E-7 2.811E-6 1.740E-5 6.464E-5 3 21
24 int:SCN5A SCN5A interactions 2.731E-7 2.993E-6 1.853E-5 7.482E-5 3 22
25 int:SNTB1 SNTB1 interactions 2.731E-7 2.993E-6 1.853E-5 7.482E-5 3 22
26 int:NDEL1 NDEL1 interactions 9.078E-7 9.567E-6 5.924E-5 2.487E-4 4 131
27 int:NOS1 NOS1 interactions 2.022E-6 2.052E-5 1.271E-4 5.540E-4 3 42
28 int:SNTB2 SNTB2 interactions 2.331E-6 2.281E-5 1.412E-4 6.387E-4 3 44
29 int:DTNB DTNB interactions 2.670E-6 2.523E-5 1.562E-4 7.316E-4 3 46
30 int:ABCA1 ABCA1 interactions 3.443E-6 3.144E-5 1.947E-4 9.433E-4 3 50
31 int:CAV3 CAV3 interactions 5.990E-6 5.295E-5 3.279E-4 1.641E-3 3 60
32 int:COG6 COG6 interactions 1.429E-5 1.223E-4 7.574E-4 3.914E-3 3 80
33 int:KCNJ4 KCNJ4 interactions 3.669E-5 2.993E-4 1.854E-3 1.005E-2 2 15
34 int:MARK2 MARK2 interactions 3.714E-5 2.993E-4 1.854E-3 1.018E-2 3 110
35 int:ADRB1 ADRB1 interactions 5.341E-5 4.182E-4 2.589E-3 1.464E-2 2 18
36 int:DTNBP1 DTNBP1 interactions 7.149E-5 5.441E-4 3.369E-3 1.959E-2 3 137
37 int:CPNE5 CPNE5 interactions 1.723E-4 1.276E-3 7.903E-3 4.722E-2 2 32
38 int:MAPK12 MAPK12 interactions 2.703E-4 1.949E-3 1.207E-2
7.406E-2
 2 40
39 int:MAST1 MAST1 interactions 3.126E-4 2.141E-3 1.326E-2
8.565E-2
 2 43
40 int:RHPN1 RHPN1 interactions 3.126E-4 2.141E-3 1.326E-2
8.565E-2
 2 43
41 int:LRCH3 LRCH3 interactions 4.063E-4 2.715E-3 1.681E-2
1.113E-1
 2 49
42 int:SGF29 SGF29 interactions 1.190E-3 7.400E-3 4.582E-2
3.261E-1
 2 84
43 int:TRBV12-3 TRBV12-3 interactions 1.242E-3 7.400E-3 4.582E-2
3.404E-1
 1 2
44 int:SSPN SSPN interactions 1.242E-3 7.400E-3 4.582E-2
3.404E-1
 1 2
45 int:SLC34A3 SLC34A3 interactions 1.242E-3 7.400E-3 4.582E-2
3.404E-1
 1 2
46 int:LOC100289290 LOC100289290 interactions 1.242E-3 7.400E-3 4.582E-2
3.404E-1
 1 2
47 int:PTPRN PTPRN interactions 1.364E-3 7.955E-3 4.926E-2
3.739E-1
 2 90
48 int:SAV1 SAV1 interactions 1.395E-3 7.961E-3 4.930E-2
3.821E-1
 2 91
49 int:SLC16A7 SLC16A7 interactions 1.863E-3 9.936E-3
6.153E-2
5.105E-1
 1 3
50 int:ADAMTS6 ADAMTS6 interactions 1.863E-3 9.936E-3
6.153E-2
5.105E-1
 1 3
Show 45 more annotations

10: Cytoband [Display Chart] 11 input genes in category / 11 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12q24.2-q24.31 12q24.2-q24.31 3.174E-4 3.491E-3 1.054E-2 3.491E-3 1 1
2 8q23-q24 8q23-q24 1.269E-3 6.979E-3 2.108E-2 1.396E-2 1 4
3 Xp21.2 Xp21.2 2.536E-3 9.061E-3 2.736E-2 2.790E-2 1 8
4 2p24 2p24 3.802E-3 9.061E-3 2.736E-2 4.183E-2 1 12
5 18q12 18q12 4.119E-3 9.061E-3 2.736E-2 4.530E-2 1 13
6 13q12 13q12 7.591E-3 1.341E-2 4.051E-2
8.351E-2
 1 24
7 20q11.2 20q11.2 8.537E-3 1.341E-2 4.051E-2
9.390E-2
 1 27
8 8p22 8p22 1.294E-2 1.779E-2
5.372E-2
1.423E-1
 1 41
9 4q12 4q12 1.794E-2 2.180E-2
6.583E-2
1.974E-1
 1 57
10 17q21 17q21 1.982E-2 2.180E-2
6.583E-2
2.180E-1
 1 63
11 16q22.1 16q22.1 3.559E-2 3.559E-2
1.075E-1
3.915E-1
 1 114
Show 6 more annotations

11: Transcription Factor Binding Site [Display Chart] 9 input genes in category / 226 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 7 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 91 Zinc fingers ZZ-type genenames.org 2.839E-8 1.135E-7 2.366E-7 1.135E-7 3 18
2 1220 Membrane associated guanylate kinases|PDZ domain containing genenames.org 1.607E-7 3.215E-7 6.697E-7 6.429E-7 4 152
3 103 X-linked mental retardation|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors genenames.org 3.338E-2 4.450E-2
9.271E-2
1.335E-1
 1 88

13: Coexpression [Display Chart] 11 input genes in category / 899 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5909 Genes involved in development of skeletal muscle (myogenesis). MSigDB H: Hallmark Gene Sets (v6.0) 2.033E-8 1.828E-5 1.349E-4 1.828E-5 5 200
2 20338664-Table2 Human Lung Oh10 38genes GeneSigDB 6.683E-7 3.004E-4 2.217E-3 6.008E-4 3 38
3 18794102-TableS1 Human Breast Yang08 840genes GeneSigDB 1.378E-5 4.128E-3 3.046E-2 1.238E-2 4 339
4 M2793 Genes up-regulated in retina cells from CRX [Gene ID=1406] knockout mice. MSigDB C6: Oncogenic Signatures (v6.0) 3.167E-5 7.117E-3
5.252E-2
 2.847E-2 3 136
5 19658189-TableS5 Human EmbryonicStemCell Xu09 622genes GeneSigDB 5.509E-5 9.906E-3
7.310E-2
 4.953E-2 4 483
6 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v6.0) 9.976E-5 1.495E-2
1.103E-1
8.968E-2
 3 200
7 16520944-Table2 Human Lung not cancer Heguy06 62genes GeneSigDB 3.583E-4 4.299E-2
3.172E-1
3.221E-1
 2 60
8 20013794-Table3 Human CardiacCells Haag09 64genes GeneSigDB 3.826E-4 4.299E-2
3.172E-1
3.439E-1
 2 62
Show 3 more annotations

14: Coexpression Atlas [Display Chart] 11 input genes in category / 627 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 500 k4 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.129E-5 7.077E-3 4.968E-2 7.077E-3 3 91
2 gudmap developingLowerUrinaryTract adult bladder 1000 k1 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.842E-5 1.518E-2
1.065E-1
 3.036E-2 3 148
3 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Conventional Leiomyosarcoma Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Conventional Leiomyosarcoma TCGA-Bone and Soft Tissue 7.572E-5 1.583E-2
1.111E-1
 4.748E-2 3 172
4 gudmap dev gonad e11.5 M SupCellPrec Sry k3 1000 dev gonad e11.5 M SupCellPrec Sry k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.315E-4 3.629E-2
2.547E-1
1.452E-1
 3 251
5 JC iEC 2500 K3 JC iEC top-relative-expression-ranked 2500 k-means-cluster#3 PCBC 4.382E-4 4.302E-2
3.019E-1
2.748E-1
 3 312
6 skeletal muscle skeletal muscle Human Protein Atlas 4.719E-4 4.302E-2
3.019E-1
2.959E-1
 3 320
7 Sample Type by Project: Shred 1/TCGA-Endometrium/Endometrial Adenocarcinoma/Endometrioid/4/1 Sample Type by Project: Shred 1/TCGA-Endometrium/Endometrial Adenocarcinoma/Endometrioid/4/1 TCGA-Endometrium 5.039E-4 4.302E-2
3.019E-1
3.160E-1
 1 1
8 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 1000 k2 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.489E-4 4.302E-2
3.019E-1
3.441E-1
 3 337
Show 3 more annotations

15: Computational [Display Chart] 8 input genes in category / 76 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5499 MODULE 512 Muscle genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.651E-4 1.761E-2
8.654E-2
 2.775E-2 2 37
2 M15550 MODULE 387 Genes in the cancer module 387. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.416E-4 1.761E-2
8.654E-2
 4.876E-2 2 49
3 M11492 MODULE 329 Genes in the cancer module 329. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.951E-4 1.761E-2
8.654E-2
5.283E-2
 2 51

16: MicroRNA [Display Chart] 11 input genes in category / 332 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-873:PITA hsa-miR-873:PITA TOP PITA 4.829E-6 1.603E-3 1.024E-2 1.603E-3 3 225
2 hsa-miR-147b:mirSVR highEffct hsa-miR-147b:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.119E-4 1.858E-2
1.186E-1
 3.716E-2 2 104
3 hsa-miR-147a:Functional MTI Functional MTI miRTarbase 2.296E-4 1.906E-2
1.216E-1
7.622E-2
 2 149
4 hsa-miR-874:PITA hsa-miR-874:PITA TOP PITA 2.296E-4 1.906E-2
1.216E-1
7.622E-2
 2 149
5 hsa-miR-143-3p:Functional MTI Functional MTI miRTarbase 5.353E-4 2.229E-2
1.423E-1
1.777E-1
 2 228
6 hsa-miR-127-5p:PITA hsa-miR-127-5p:PITA TOP PITA 6.325E-4 2.229E-2
1.423E-1
2.100E-1
 2 248
7 hsa-miR-935:PITA hsa-miR-935:PITA TOP PITA 8.159E-4 2.229E-2
1.423E-1
2.709E-1
 2 282
8 hsa-miR-491-3p:PITA hsa-miR-491-3p:PITA TOP PITA 8.448E-4 2.229E-2
1.423E-1
2.805E-1
 2 287
9 hsa-miR-509-3-5p:PITA hsa-miR-509-3-5p:PITA TOP PITA 8.861E-4 2.229E-2
1.423E-1
2.942E-1
 2 294
10 hsa-miR-509-5p:PITA hsa-miR-509-5p:PITA TOP PITA 8.861E-4 2.229E-2
1.423E-1
2.942E-1
 2 294
11 hsa-miR-566:mirSVR lowEffct hsa-miR-566:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.022E-3 2.229E-2
1.423E-1
3.393E-1
 2 316
12 hsa-miR-578:PITA hsa-miR-578:PITA TOP PITA 1.161E-3 2.229E-2
1.423E-1
3.853E-1
 2 337
13 hsa-miR-153:PITA hsa-miR-153:PITA TOP PITA 1.202E-3 2.229E-2
1.423E-1
3.990E-1
 2 343
14 hsa-miR-342-5p:mirSVR highEffct hsa-miR-342-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.230E-3 2.229E-2
1.423E-1
4.082E-1
 2 347
15 hsa-miR-3666:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.351E-3 2.229E-2
1.423E-1
4.486E-1
 2 364
16 hsa-miR-4295:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.366E-3 2.229E-2
1.423E-1
4.535E-1
 2 366
17 hsa-miR-1468:mirSVR highEffct hsa-miR-1468:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.373E-3 2.229E-2
1.423E-1
4.560E-1
 2 367
18 hsa-miR-301b-3p:Non-Functional MTI Non-Functional MTI miRTarbase 1.433E-3 2.229E-2
1.423E-1
4.758E-1
 2 375
19 hsa-miR-125b-1*:mirSVR lowEffct hsa-miR-125b-1*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.448E-3 2.229E-2
1.423E-1
4.808E-1
 2 377
20 hsa-miR-1225-5p:mirSVR highEffct hsa-miR-1225-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.556E-3 2.229E-2
1.423E-1
5.166E-1
 2 391
21 hsa-miR-3193:mirSVR lowEffct hsa-miR-3193:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.572E-3 2.229E-2
1.423E-1
5.218E-1
 2 393
22 hsa-miR-301a-3p:Functional MTI Functional MTI miRTarbase 1.588E-3 2.229E-2
1.423E-1
5.271E-1
 2 395
23 hsa-miR-454-3p:Functional MTI Functional MTI miRTarbase 1.595E-3 2.229E-2
1.423E-1
5.297E-1
 2 396
24 hsa-miR-130a-3p:Functional MTI Functional MTI miRTarbase 1.611E-3 2.229E-2
1.423E-1
5.350E-1
 2 398
25 hsa-miR-574-5p:Functional MTI Functional MTI miRTarbase 1.750E-3 2.255E-2
1.440E-1
5.809E-1
 2 415
26 hsa-miR-874:mirSVR highEffct hsa-miR-874:mirSVR conserved highEffect-0.5 MicroRNA.org 1.766E-3 2.255E-2
1.440E-1
5.864E-1
 2 417
27 hsa-miR-579:PITA hsa-miR-579:PITA TOP PITA 1.919E-3 2.283E-2
1.458E-1
6.372E-1
 2 435
28 hsa-miR-135b:PITA hsa-miR-135b:PITA TOP PITA 2.043E-3 2.283E-2
1.458E-1
6.782E-1
 2 449
29 hsa-miR-135a:PITA hsa-miR-135a:PITA TOP PITA 2.043E-3 2.283E-2
1.458E-1
6.782E-1
 2 449
30 hsa-miR-542-5p:PITA hsa-miR-542-5p:PITA TOP PITA 2.130E-3 2.283E-2
1.458E-1
7.071E-1
 1 14
31 hsa-miR-6867-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.133E-3 2.283E-2
1.458E-1
7.082E-1
 2 459
32 hsa-miR-886-3p:mirSVR lowEffct hsa-miR-886-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.263E-3 2.283E-2
1.458E-1
7.512E-1
 2 473
33 hsa-miR-4304:mirSVR lowEffct hsa-miR-4304:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.310E-3 2.283E-2
1.458E-1
7.669E-1
 2 478
34 hsa-miR-1825:mirSVR highEffct hsa-miR-1825:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.338E-3 2.283E-2
1.458E-1
7.763E-1
 2 481
Show 29 more annotations

17: Drug [Display Chart] 11 input genes in category / 4969 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000146339 DAPs Stitch 7.437E-24 3.696E-20 3.359E-19 3.696E-20 10 92
2 CID005356750 Evans blue dye Stitch 1.184E-11 2.943E-8 2.675E-7 5.886E-8 6 127
3 CID000084102 To 2 Stitch 9.887E-11 1.638E-7 1.488E-6 4.913E-7 5 69
4 CID000008202 methyl 9-octadecenoate Stitch 1.169E-9 1.452E-6 1.320E-5 5.809E-6 5 112
5 CID005281925 benzoxazolinate Stitch 1.660E-9 1.650E-6 1.500E-5 8.251E-6 3 6
6 CID000010701 2-nitroimidazole Stitch 2.390E-9 1.979E-6 1.799E-5 1.187E-5 5 129
7 CID010062733 M1-L Stitch 3.913E-9 2.777E-6 2.524E-5 1.944E-5 4 44
8 CID000448562 AC1L9M3B Stitch 1.498E-8 9.303E-6 8.455E-5 7.443E-5 4 61
9 CID000234384 alph a- Stitch 2.476E-8 1.367E-5 1.243E-4 1.231E-4 4 69
10 CID000002380 biopterin Stitch 4.994E-8 2.482E-5 2.255E-4 2.482E-4 4 82
11 CID000024751 Pluronic Stitch 7.282E-8 3.289E-5 2.989E-4 3.618E-4 4 90
12 CID000069602 N-acetylhistamine Stitch 2.027E-7 8.059E-5 7.325E-4 1.007E-3 4 116
13 CID000192097 bromoacetylcholamine Stitch 2.109E-7 8.059E-5 7.325E-4 1.048E-3 2 2
14 CID000001086 dithionite Stitch 5.689E-7 1.948E-4 1.771E-3 2.827E-3 4 150
15 CID000003524 AC1L1G4Q Stitch 5.881E-7 1.948E-4 1.771E-3 2.922E-3 3 36
16 CID000004386 diphenylamine-2-carboxylate Stitch 8.533E-7 2.650E-4 2.408E-3 4.240E-3 4 166
17 CID005281917 C-1027 chromophore Stitch 1.264E-6 3.491E-4 3.172E-3 6.283E-3 2 4
18 CID000656986 A8b Stitch 1.264E-6 3.491E-4 3.172E-3 6.283E-3 2 4
19 5421 UP Nimodipine [66085-59-4]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.557E-6 3.972E-4 3.610E-3 7.736E-3 4 193
20 4135 DN Memantine Hydrochloride [41100-52-1]; Down 200; 18.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.689E-6 3.972E-4 3.610E-3 8.394E-3 4 197
21 CID000003467 gentamicin Stitch 1.724E-6 3.972E-4 3.610E-3 8.565E-3 4 198
22 2903 UP Reserpinic acid hydrochloride; Up 200; 9.2uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.759E-6 3.972E-4 3.610E-3 8.739E-3 4 199
23 CID000016474 DTNP Stitch 3.159E-6 6.826E-4 6.204E-3 1.570E-2 2 6
24 CID000000795 imidazole Stitch 3.826E-6 7.922E-4 7.200E-3 1.901E-2 4 242
25 CID000107754 diethylamine NONOate Stitch 4.866E-6 9.672E-4 8.791E-3 2.418E-2 3 72
26 CID000004020 mazindol Stitch 5.730E-6 1.095E-3 9.953E-3 2.847E-2 3 76
27 CID000024572 lead arsenate Stitch 9.225E-6 1.698E-3 1.543E-2 4.584E-2 3 89
28 CID003359494 S-nitrosocysteine Stitch 1.053E-5 1.869E-3 1.698E-2
5.232E-2
 3 93
29 CID000008904 sodium decyl sulfate Stitch 1.388E-5 2.378E-3 2.161E-2
6.897E-2
 2 12
30 CID000003976 LY83583 Stitch 1.516E-5 2.485E-3 2.258E-2
7.535E-2
 3 105
31 CID000447688 Cymal-6 Stitch 1.640E-5 2.485E-3 2.258E-2
8.149E-2
 2 13
32 CID000193682 X5 0 Stitch 1.640E-5 2.485E-3 2.258E-2
8.149E-2
 2 13
33 CID000014797 potassium hydroxide Stitch 1.650E-5 2.485E-3 2.258E-2
8.199E-2
 3 108
34 CID000151203 diaminoguanidine Stitch 1.913E-5 2.716E-3 2.468E-2
9.504E-2
 2 14
35 CID003035443 GEA 3162 Stitch 1.913E-5 2.716E-3 2.468E-2
9.504E-2
 2 14
36 CID000119498 C11122 Stitch 2.206E-5 2.964E-3 2.693E-2
1.096E-1
 2 15
37 CID000008330 TCNB Stitch 2.207E-5 2.964E-3 2.693E-2
1.097E-1
 3 119
38 CID000002474 bupivacaine Stitch 2.557E-5 3.343E-3 3.039E-2
1.270E-1
 3 125
39 CID000012234 thiocholine Stitch 3.213E-5 4.093E-3 3.720E-2
1.596E-1
 2 18
40 CID000036811 dobutamine Stitch 3.587E-5 4.247E-3 3.860E-2
1.783E-1
 3 140
41 CID000472323 O-12 Stitch 3.590E-5 4.247E-3 3.860E-2
1.784E-1
 2 19
42 CID000001383 NOC-7 Stitch 3.590E-5 4.247E-3 3.860E-2
1.784E-1
 2 19
43 CID000444690 Ge 3 Stitch 4.406E-5 5.091E-3 4.627E-2
2.189E-1
 2 21
44 CID000122980 trichloromethyl Stitch 4.845E-5 5.472E-3 4.973E-2
2.408E-1
 2 22
45 CID000001160 AC1L1AUZ Stitch 5.048E-5 5.575E-3
5.066E-2
2.509E-1
 3 157
46 CID000089871 Disulfides Stitch 5.786E-5 6.250E-3
5.680E-2
2.875E-1
 2 24
47 CID000151422 DETCA Stitch 6.288E-5 6.445E-3
5.857E-2
3.124E-1
 2 25
48 CID005491930 oxyhyponitrite Stitch 6.810E-5 6.445E-3
5.857E-2
3.384E-1
 2 26
49 CID011219835 PTC124 Stitch 7.353E-5 6.445E-3
5.857E-2
3.653E-1
 2 27
50 3244 UP Corticosterone [50-22-6]; Up 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 8.092E-5 6.445E-3
5.857E-2
4.021E-1
 3 184
Show 45 more annotations

18: Disease [Display Chart] 11 input genes in category / 528 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0917713 Becker Muscular Dystrophy DisGeNET Curated 1.168E-11 6.167E-9 4.223E-8 6.167E-9 5 33
2 C2936331 Sarcoglycanopathies DisGeNET Curated 2.408E-11 6.356E-9 4.352E-8 1.271E-8 4 10
3 C0013264 Muscular Dystrophy, Duchenne DisGeNET Curated 1.023E-9 1.801E-7 1.233E-6 5.403E-7 6 189
4 C1839666 Calf muscle pseudohypertrophy DisGeNET Curated 2.325E-9 3.069E-7 2.102E-6 1.228E-6 3 5
5 C0410173 Severe autosomal recessive muscular dystrophy of childhood - North African type (disorder) DisGeNET Curated 4.649E-9 4.909E-7 3.361E-6 2.454E-6 3 6
6 C0410158 Muscle damage DisGeNET BeFree 1.538E-8 1.354E-6 9.269E-6 8.122E-6 4 44
7 C0026850 Muscular Dystrophy DisGeNET Curated 8.248E-8 6.221E-6 4.260E-5 4.355E-5 5 186
8 C0686353 Muscular Dystrophies, Limb-Girdle DisGeNET Curated 1.290E-7 8.516E-6 5.831E-5 6.813E-5 4 74
9 C2930900 Beta-sarcoglycanopathy DisGeNET BeFree 4.189E-7 2.212E-5 1.515E-4 2.212E-4 2 2
10 C1858593 Limb-girdle muscular dystrophy, type 2E DisGeNET Curated 4.189E-7 2.212E-5 1.515E-4 2.212E-4 2 2
11 C0151576 Elevated creatine kinase DisGeNET Curated 8.191E-7 3.604E-5 2.468E-4 4.325E-4 4 117
12 C0241005 Creatine phosphokinase serum increased DisGeNET Curated 8.191E-7 3.604E-5 2.468E-4 4.325E-4 4 117
13 C0456702 Severe childhood autosomal recessive muscular dystrophy DisGeNET BeFree 1.256E-6 5.102E-5 3.494E-4 6.633E-4 2 3
14 C1864711 Muscle biopsy shows dystrophic changes DisGeNET Curated 2.098E-6 7.914E-5 5.419E-4 1.108E-3 3 39
15 C1456418 Absence of muscle DisGeNET BeFree 2.512E-6 8.841E-5 6.054E-4 1.326E-3 2 4
16 C0026848 Myopathy DisGeNET Curated 3.068E-6 1.012E-4 6.932E-4 1.620E-3 5 386
17 C0878544 Cardiomyopathies DisGeNET Curated 5.384E-6 1.672E-4 1.145E-3 2.843E-3 5 433
18 C2936332 Alpha-Sarcoglycanopathies DisGeNET Curated 6.274E-6 1.840E-4 1.260E-3 3.313E-3 2 6
19 C3542021 Duchenne and Becker Muscular Dystrophy DisGeNET BeFree 1.880E-5 5.223E-4 3.576E-3 9.924E-3 2 10
20 C1858127 Limb-girdle muscle weakness DisGeNET Curated 2.755E-5 6.923E-4 4.740E-3 1.454E-2 2 12
21 C2931687 Dysferlinopathy DisGeNET BeFree 2.755E-5 6.923E-4 4.740E-3 1.454E-2 2 12
22 C1850530 Flexion contractures of joints DisGeNET Curated 2.920E-5 6.923E-4 4.740E-3 1.542E-2 3 93
23 C0333068 Flexion contracture DisGeNET Curated 3.016E-5 6.923E-4 4.740E-3 1.592E-2 3 94
24 C1834674 Bethlem myopathy DisGeNET Curated 3.254E-5 6.997E-4 4.791E-3 1.718E-2 2 13
25 C0009918 Contracture of joint DisGeNET Curated 3.313E-5 6.997E-4 4.791E-3 1.749E-2 3 97
26 C1096903 Sialic Acid Storage Disease, Finnish Type (disorder) DisGeNET Curated 4.377E-5 8.890E-4 6.087E-3 2.311E-2 2 15
27 C0038220 Status Epilepticus DisGeNET Curated 6.573E-5 1.270E-3 8.696E-3 3.471E-2 3 122
28 C0009917 Contracture DisGeNET Curated 6.735E-5 1.270E-3 8.696E-3 3.556E-2 3 123
29 C0575071 Gowers sign present DisGeNET Curated 1.147E-4 2.018E-3 1.382E-2
6.055E-2
 2 24
30 C0234182 Gowers sign DisGeNET Curated 1.147E-4 2.018E-3 1.382E-2
6.055E-2
 2 24
31 C0025281 Meniere Disease DisGeNET BeFree 1.803E-4 3.072E-3 2.103E-2
9.522E-2
 2 30
32 C0699743 Congenital muscular dystrophy (disorder) DisGeNET Curated 2.055E-4 3.390E-3 2.322E-2
1.085E-1
 2 32
33 C2940786 Thyroid Hormone Resistance Syndrome DisGeNET Curated 2.322E-4 3.677E-3 2.518E-2
1.226E-1
 2 34
34 C0234958 muscle degeneration DisGeNET Curated 2.368E-4 3.677E-3 2.518E-2
1.250E-1
 3 188
35 C0270960 Congenital myopathy (disorder) DisGeNET BeFree 2.606E-4 3.932E-3 2.692E-2
1.376E-1
 2 36
36 C0339510 Vitelliform Macular Dystrophy DisGeNET Curated 2.754E-4 4.039E-3 2.766E-2
1.454E-1
 2 37
37 C2678065 Myofibrillar Myopathy DisGeNET Curated 3.222E-4 4.598E-3 3.148E-2
1.701E-1
 2 40
38 C0024591 Malignant hyperpyrexia due to anesthesia DisGeNET Curated 4.266E-4 5.600E-3 3.835E-2
2.252E-1
 2 46
39 C1332347 Atypical Ductal Breast Hyperplasia DisGeNET BeFree 4.266E-4 5.600E-3 3.835E-2
2.252E-1
 2 46
40 C0020758 Congenital ichthyosis DisGeNET Curated 4.645E-4 5.600E-3 3.835E-2
2.453E-1
 2 48
41 C0221765 Chronic schizophrenia DisGeNET Curated 4.841E-4 5.600E-3 3.835E-2
2.556E-1
 2 49
42 C0024003 Lordosis DisGeNET Curated 6.100E-4 5.600E-3 3.835E-2
3.221E-1
 2 55
43 C2751830 Long Qt Syndrome 12 DisGeNET Curated 6.788E-4 5.600E-3 3.835E-2
3.584E-1
 1 1
44 cv:C0917713 Becker muscular dystrophy Clinical Variations 6.788E-4 5.600E-3 3.835E-2
3.584E-1
 1 1
45 cv:C1842550 Limb-girdle muscular dystrophy, type 2D Clinical Variations 6.788E-4 5.600E-3 3.835E-2
3.584E-1
 1 1
46 C2875313 Severe [Duchenne] muscular dystrophy DisGeNET BeFree 6.788E-4 5.600E-3 3.835E-2
3.584E-1
 1 1
47 OMIN:302045 CARDIOMYOPATHY, DILATED, 3B; CMD3B OMIM 6.788E-4 5.600E-3 3.835E-2
3.584E-1
 1 1
48 cv:C1858593 Limb-girdle muscular dystrophy, type 2E Clinical Variations 6.788E-4 5.600E-3 3.835E-2
3.584E-1
 1 1
49 OMIN:604169 LEFT VENTRICULAR NONCOMPACTION 1; LVNC1 OMIM 6.788E-4 5.600E-3 3.835E-2
3.584E-1
 1 1
50 C4275182 Autosomal recessive limb girdle muscular dystrophy type 2D DisGeNET BeFree 6.788E-4 5.600E-3 3.835E-2
3.584E-1
 1 1
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