Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc378_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 21 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042813 Wnt-activated receptor activity 1.092E-21 2.293E-20 8.359E-20 2.293E-20 7 22
2 GO:0017147 Wnt-protein binding 2.155E-20 2.263E-19 8.249E-19 4.526E-19 7 32
3 GO:0030165 PDZ domain binding 7.634E-6 5.344E-5 1.948E-4 1.603E-4 3 114
4 GO:0005109 frizzled binding 8.425E-5 4.423E-4 1.612E-3 1.769E-3 2 38
5 GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway 7.501E-4 3.150E-3 1.148E-2 1.575E-2 1 2
6 GO:0005113 patched binding 2.998E-3 8.379E-3 3.054E-2
6.295E-2
 1 8
7 GO:0071936 coreceptor activity involved in Wnt signaling pathway 2.998E-3 8.379E-3 3.054E-2
6.295E-2
 1 8
8 GO:0019534 toxin transmembrane transporter activity 3.746E-3 8.379E-3 3.054E-2
7.866E-2
 1 10
9 GO:0031625 ubiquitin protein ligase binding 4.266E-3 8.379E-3 3.054E-2
8.959E-2
 2 273
10 GO:0001664 G protein-coupled receptor binding 4.358E-3 8.379E-3 3.054E-2
9.152E-2
 2 276
11 GO:0044389 ubiquitin-like protein ligase binding 4.389E-3 8.379E-3 3.054E-2
9.217E-2
 2 277
12 GO:0005041 low-density lipoprotein particle receptor activity 5.241E-3 9.171E-3 3.343E-2
1.101E-1
 1 14
13 GO:0034185 apolipoprotein binding 5.987E-3 9.672E-3 3.526E-2
1.257E-1
 1 16
14 GO:0030228 lipoprotein particle receptor activity 7.107E-3 1.066E-2 3.886E-2
1.492E-1
 1 19
15 GO:0015026 coreceptor activity 1.565E-2 2.191E-2
7.988E-2
3.287E-1
 1 42
16 GO:0038024 cargo receptor activity 2.634E-2 3.456E-2
1.260E-1
5.530E-1
 1 71
17 GO:0019210 kinase inhibitor activity 3.365E-2 4.156E-2
1.515E-1
7.066E-1
 1 91
18 GO:0019955 cytokine binding 3.801E-2 4.434E-2
1.616E-1
7.982E-1
 1 103
Show 13 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 676 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0035567 non-canonical Wnt signaling pathway 2.896E-15 1.958E-12 1.389E-11 1.958E-12 7 159
2 GO:0060070 canonical Wnt signaling pathway 3.164E-13 1.069E-10 7.586E-10 2.139E-10 7 308
3 GO:0016055 Wnt signaling pathway 8.865E-12 1.998E-9 1.417E-8 5.993E-9 7 494
4 GO:2000027 regulation of animal organ morphogenesis 5.810E-11 9.820E-9 6.966E-8 3.928E-8 6 268
5 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 1.565E-10 1.844E-8 1.308E-7 1.058E-7 5 113
6 GO:0090175 regulation of establishment of planar polarity 1.636E-10 1.844E-8 1.308E-7 1.106E-7 5 114
7 GO:0001736 establishment of planar polarity 2.719E-10 2.392E-8 1.697E-7 1.838E-7 5 126
8 GO:0007164 establishment of tissue polarity 2.830E-10 2.392E-8 1.697E-7 1.913E-7 5 127
9 GO:0001738 morphogenesis of a polarized epithelium 4.807E-10 3.610E-8 2.561E-7 3.249E-7 5 141
10 GO:0051090 regulation of DNA-binding transcription factor activity 8.489E-8 5.739E-6 4.071E-5 5.739E-5 5 395
11 GO:0045992 negative regulation of embryonic development 1.061E-7 6.521E-6 4.626E-5 7.173E-5 3 28
12 GO:0061351 neural precursor cell proliferation 2.087E-7 1.176E-5 8.341E-5 1.411E-4 4 166
13 GO:0007223 Wnt signaling pathway, calcium modulating pathway 2.955E-7 1.523E-5 1.081E-4 1.997E-4 3 39
14 GO:0021915 neural tube development 3.154E-7 1.523E-5 1.081E-4 2.132E-4 4 184
15 GO:0048854 brain morphogenesis 4.278E-7 1.928E-5 1.368E-4 2.892E-4 3 44
16 GO:0007405 neuroblast proliferation 1.159E-6 4.899E-5 3.475E-4 7.838E-4 3 61
17 GO:1904693 midbrain morphogenesis 1.815E-6 7.219E-5 5.121E-4 1.227E-3 2 6
18 GO:2000648 positive regulation of stem cell proliferation 2.351E-6 8.828E-5 6.262E-4 1.589E-3 3 77
19 GO:0033278 cell proliferation in midbrain 2.541E-6 9.041E-5 6.414E-4 1.718E-3 2 7
20 GO:0048562 embryonic organ morphogenesis 3.095E-6 1.046E-4 7.422E-4 2.092E-3 4 326
21 GO:0008544 epidermis development 3.658E-6 1.178E-4 8.355E-4 2.473E-3 4 340
22 GO:0030901 midbrain development 4.435E-6 1.336E-4 9.475E-4 2.998E-3 3 95
23 GO:0022404 molting cycle process 5.022E-6 1.336E-4 9.475E-4 3.395E-3 3 99
24 GO:0001942 hair follicle development 5.022E-6 1.336E-4 9.475E-4 3.395E-3 3 99
25 GO:0022405 hair cycle process 5.022E-6 1.336E-4 9.475E-4 3.395E-3 3 99
26 GO:0060562 epithelial tube morphogenesis 5.285E-6 1.336E-4 9.475E-4 3.573E-3 4 373
27 GO:0098773 skin epidermis development 5.334E-6 1.336E-4 9.475E-4 3.606E-3 3 101
28 GO:0001843 neural tube closure 5.659E-6 1.358E-4 9.635E-4 3.825E-3 3 103
29 GO:0060606 tube closure 5.826E-6 1.358E-4 9.635E-4 3.938E-3 3 104
30 GO:0014020 primary neural tube formation 6.527E-6 1.471E-4 1.043E-3 4.413E-3 3 108
31 GO:0021549 cerebellum development 7.089E-6 1.497E-4 1.062E-3 4.792E-3 3 111
32 GO:0072091 regulation of stem cell proliferation 7.089E-6 1.497E-4 1.062E-3 4.792E-3 3 111
33 GO:0035239 tube morphogenesis 8.067E-6 1.652E-4 1.172E-3 5.453E-3 4 415
34 GO:0042303 molting cycle 8.962E-6 1.673E-4 1.187E-3 6.058E-3 3 120
35 GO:0042633 hair cycle 8.962E-6 1.673E-4 1.187E-3 6.058E-3 3 120
36 GO:0001841 neural tube formation 9.188E-6 1.673E-4 1.187E-3 6.211E-3 3 121
37 GO:0071397 cellular response to cholesterol 9.428E-6 1.673E-4 1.187E-3 6.373E-3 2 13
38 GO:0022037 metencephalon development 9.652E-6 1.673E-4 1.187E-3 6.525E-3 3 123
39 GO:0045995 regulation of embryonic development 9.652E-6 1.673E-4 1.187E-3 6.525E-3 3 123
40 GO:0048568 embryonic organ development 1.423E-5 2.333E-4 1.655E-3 9.616E-3 4 479
41 GO:0021794 thalamus development 1.450E-5 2.333E-4 1.655E-3 9.800E-3 2 16
42 GO:0036315 cellular response to sterol 1.450E-5 2.333E-4 1.655E-3 9.800E-3 2 16
43 GO:0001838 embryonic epithelial tube formation 1.517E-5 2.380E-4 1.688E-3 1.026E-2 3 143
44 GO:0072175 epithelial tube formation 1.549E-5 2.380E-4 1.688E-3 1.047E-2 3 144
45 GO:0060231 mesenchymal to epithelial transition 2.065E-5 3.063E-4 2.173E-3 1.396E-2 2 19
46 GO:0035148 tube formation 2.084E-5 3.063E-4 2.173E-3 1.409E-2 3 159
47 GO:0090090 negative regulation of canonical Wnt signaling pathway 2.329E-5 3.350E-4 2.376E-3 1.574E-2 3 165
48 GO:0072089 stem cell proliferation 2.458E-5 3.461E-4 2.456E-3 1.661E-2 3 168
49 GO:0030902 hindbrain development 2.546E-5 3.513E-4 2.492E-3 1.721E-2 3 170
50 GO:0016331 morphogenesis of embryonic epithelium 2.637E-5 3.565E-4 2.529E-3 1.783E-2 3 172
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 43 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005901 caveola 5.186E-4 1.333E-2
5.798E-2
 2.230E-2 2 96
2 GO:0044853 plasma membrane raft 6.199E-4 1.333E-2
5.798E-2
 2.666E-2 2 105
3 GO:0030666 endocytic vesicle membrane 1.360E-3 1.578E-2
6.865E-2
5.850E-2
 2 156
4 GO:0044294 dendritic growth cone 1.835E-3 1.578E-2
6.865E-2
7.891E-2
 1 5
5 GO:1990851 Wnt-Frizzled-LRP5/6 complex 1.835E-3 1.578E-2
6.865E-2
7.891E-2
 1 5
6 GO:0030139 endocytic vesicle 3.862E-3 2.289E-2
9.956E-2
1.661E-1
 2 265
7 GO:0044292 dendrite terminus 4.765E-3 2.289E-2
9.956E-2
2.049E-1
 1 13
8 GO:1990909 Wnt signalosome 5.131E-3 2.289E-2
9.956E-2
2.206E-1
 1 14
9 GO:0032433 filopodium tip 5.497E-3 2.289E-2
9.956E-2
2.363E-1
 1 15
10 GO:0016324 apical plasma membrane 6.101E-3 2.289E-2
9.956E-2
2.623E-1
 2 335
11 GO:0045121 membrane raft 6.387E-3 2.289E-2
9.956E-2
2.746E-1
 2 343
12 GO:0098857 membrane microdomain 6.387E-3 2.289E-2
9.956E-2
2.746E-1
 2 343
13 GO:0016327 apicolateral plasma membrane 6.958E-3 2.301E-2
1.001E-1
2.992E-1
 1 19
14 GO:0045177 apical part of cell 9.803E-3 3.011E-2
1.310E-1
4.215E-1
 2 428
15 GO:0044295 axonal growth cone 1.060E-2 3.040E-2
1.322E-1
4.559E-1
 1 29
16 GO:0048786 presynaptic active zone 1.351E-2 3.631E-2
1.580E-1
5.810E-1
 1 37
17 GO:0097542 ciliary tip 1.641E-2 4.151E-2
1.806E-1
7.057E-1
 1 45
18 GO:0030669 clathrin-coated endocytic vesicle membrane 1.822E-2 4.353E-2
1.893E-1
7.835E-1
 1 50
19 GO:0016328 lateral plasma membrane 1.931E-2 4.369E-2
1.901E-1
8.301E-1
 1 53
Show 14 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 334 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 7 input genes in category / 686 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000929 open neural tube 1.974E-7 1.354E-4 9.625E-4 1.354E-4 5 261
2 MP:0003720 abnormal neural tube closure 1.533E-6 3.733E-4 2.653E-3 1.052E-3 5 394
3 MP:0004399 abnormal cochlear outer hair cell morphology 1.632E-6 3.733E-4 2.653E-3 1.120E-3 4 155
4 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles 2.476E-6 3.799E-4 2.700E-3 1.699E-3 3 44
5 MP:0002622 abnormal cochlear hair cell morphology 4.253E-6 3.799E-4 2.700E-3 2.918E-3 4 197
6 MP:0002102 abnormal ear morphology 4.650E-6 3.799E-4 2.700E-3 3.190E-3 5 493
7 MP:0003308 abnormal cochlear sensory epithelium morphology 4.793E-6 3.799E-4 2.700E-3 3.288E-3 4 203
8 MP:0000045 abnormal hair cell morphology 4.984E-6 3.799E-4 2.700E-3 3.419E-3 4 205
9 MP:0000042 abnormal organ of Corti morphology 4.984E-6 3.799E-4 2.700E-3 3.419E-3 4 205
10 MP:0000972 abnormal mechanoreceptor morphology 7.741E-6 4.660E-4 3.313E-3 5.310E-3 4 229
11 MP:0003169 abnormal scala media morphology 8.151E-6 4.660E-4 3.313E-3 5.592E-3 4 232
12 MP:0004426 abnormal cochlear labyrinth morphology 8.151E-6 4.660E-4 3.313E-3 5.592E-3 4 232
13 MP:0000031 abnormal cochlea morphology 1.012E-5 5.341E-4 3.797E-3 6.943E-3 4 245
14 MP:0003051 curly tail 1.153E-5 5.650E-4 4.016E-3 7.910E-3 3 73
15 MP:0000035 abnormal membranous labyrinth morphology 1.381E-5 6.033E-4 4.289E-3 9.476E-3 4 265
16 MP:0012139 increased forebrain size 1.407E-5 6.033E-4 4.289E-3 9.652E-3 2 9
17 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology 2.240E-5 8.712E-4 6.193E-3 1.537E-2 3 91
18 MP:0000026 abnormal inner ear morphology 2.286E-5 8.712E-4 6.193E-3 1.568E-2 4 301
19 MP:0013933 short Meckel's cartilage 3.551E-5 1.282E-3 9.114E-3 2.436E-2 2 14
20 MP:0030457 abnormal molar cusp morphology 5.302E-5 1.819E-3 1.293E-2 3.637E-2 2 17
21 MP:0004393 abnormal cochlear inner hair cell morphology 5.942E-5 1.859E-3 1.322E-2 4.076E-2 3 126
22 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles 5.963E-5 1.859E-3 1.322E-2 4.090E-2 2 18
23 MP:0002111 abnormal tail morphology 9.374E-5 2.796E-3 1.987E-2
6.430E-2
 4 431
24 MP:0003932 abnormal molar crown morphology 1.074E-4 2.946E-3 2.094E-2
7.365E-2
 2 24
25 MP:0030026 small Meckel's cartilage 1.074E-4 2.946E-3 2.094E-2
7.365E-2
 2 24
26 MP:0000556 abnormal hindlimb morphology 1.250E-4 3.299E-3 2.345E-2
8.578E-2
 4 464
27 MP:0000784 forebrain hypoplasia 1.924E-4 4.889E-3 3.476E-2
1.320E-1
 2 32
28 MP:0004249 abnormal crista ampullaris morphology 2.048E-4 5.017E-3 3.567E-2
1.405E-1
 2 33
29 MP:0003149 abnormal tectorial membrane morphology 2.175E-4 5.145E-3 3.658E-2
1.492E-1
 2 34
30 MP:0008488 abnormal semicircular canal ampulla morphology 2.868E-4 6.559E-3 4.663E-2
1.968E-1
 2 39
31 MP:0006103 abnormal midbrain roof plate morphology 3.172E-4 6.800E-3 4.834E-2
2.176E-1
 2 41
32 MP:0006104 abnormal tectum morphology 3.172E-4 6.800E-3 4.834E-2
2.176E-1
 2 41
33 MP:0004532 abnormal inner hair cell stereociliary bundle morphology 3.825E-4 7.951E-3
5.652E-2
2.624E-1
 2 45
34 MP:0030608 decreased tooth number 5.111E-4 1.002E-2
7.120E-2
3.506E-1
 2 52
35 MP:0002689 abnormal molar morphology 5.111E-4 1.002E-2
7.120E-2
3.506E-1
 2 52
36 MP:0001340 abnormal eyelid morphology 5.256E-4 1.002E-2
7.120E-2
3.606E-1
 3 263
37 MP:0005587 abnormal Meckel's cartilage morphology 6.581E-4 1.220E-2
8.673E-2
4.514E-1
 2 59
38 MP:0030611 abnormal tooth number 7.984E-4 1.441E-2
1.025E-1
5.477E-1
 2 65
39 MP:0002428 abnormal semicircular canal morphology 8.231E-4 1.448E-2
1.029E-1
5.647E-1
 2 66
40 MP:0012138 decreased forebrain size 8.482E-4 1.455E-2
1.034E-1
5.818E-1
 2 67
41 MP:0002729 abnormal inner ear canal morphology 9.255E-4 1.549E-2
1.101E-1
6.349E-1
 2 70
42 MP:0002187 abnormal fibula morphology 9.520E-4 1.555E-2
1.105E-1
6.531E-1
 2 71
43 MP:0012137 abnormal forebrain size 9.789E-4 1.562E-2
1.110E-1
6.715E-1
 2 72
44 MP:0000371 diluted coat color 1.090E-3 1.700E-2
1.208E-1
7.478E-1
 2 76
45 MP:0001706 abnormal left-right axis patterning 1.148E-3 1.712E-2
1.217E-1
7.875E-1
 2 78
46 MP:0005238 increased brain size 1.148E-3 1.712E-2
1.217E-1
7.875E-1
 2 78
47 MP:0001701 incomplete embryo turning 1.177E-3 1.718E-2
1.222E-1
8.077E-1
 2 79
48 MP:0001286 abnormal eye development 1.211E-3 1.731E-2
1.230E-1
8.307E-1
 3 350
49 MP:0030514 absent Tomes' process 1.352E-3 1.783E-2
1.268E-1
9.272E-1
 1 2
50 MP:0001133 impaired luteal cell differentiation 1.352E-3 1.783E-2
1.268E-1
9.272E-1
 1 2
Show 45 more annotations

6: Domain [Display Chart] 7 input genes in category / 45 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR015526 Frizzled/SFRP InterPro 9.336E-19 4.201E-17 1.846E-16 4.201E-17 6 16
2 SM00063 FRI SMART 4.518E-18 9.488E-17 4.170E-16 2.033E-16 6 20
3 1.10.2000.10 - Gene3D 6.325E-18 9.488E-17 4.170E-16 2.846E-16 6 21
4 PF01392 Fz Pfam 1.569E-17 1.176E-16 5.171E-16 7.059E-16 6 24
5 PS50038 FZ PROSITE 1.569E-17 1.176E-16 5.171E-16 7.059E-16 6 24
6 IPR020067 Frizzled dom InterPro 1.569E-17 1.176E-16 5.171E-16 7.059E-16 6 24
7 IPR000539 Frizzled InterPro 5.044E-16 2.522E-15 1.108E-14 2.270E-14 5 11
8 SM01330 Frizzled SMART 5.044E-16 2.522E-15 1.108E-14 2.270E-14 5 11
9 PF01534 Frizzled Pfam 5.044E-16 2.522E-15 1.108E-14 2.270E-14 5 11
10 IPR017981 GPCR 2-like InterPro 5.937E-12 2.425E-11 1.066E-10 2.672E-10 5 60
11 IPR000832 GPCR 2 secretin-like InterPro 5.937E-12 2.425E-11 1.066E-10 2.672E-10 5 60
12 PS50261 G PROTEIN RECEP F2 4 PROSITE 6.466E-12 2.425E-11 1.066E-10 2.910E-10 5 61
13 IPR026543 FZD6 InterPro 3.736E-4 9.341E-4 4.105E-3 1.681E-2 1 1
14 IPR026551 FZD4 InterPro 3.736E-4 9.341E-4 4.105E-3 1.681E-2 1 1
15 IPR026552 FZD7 InterPro 3.736E-4 9.341E-4 4.105E-3 1.681E-2 1 1
16 IPR026560 SFRP4 InterPro 3.736E-4 9.341E-4 4.105E-3 1.681E-2 1 1
17 IPR026553 FZD3 vertebrates InterPro 3.736E-4 9.341E-4 4.105E-3 1.681E-2 1 1
18 IPR026544 SMO InterPro 3.736E-4 9.341E-4 4.105E-3 1.681E-2 1 1
19 IPR017049 LRP5/6 InterPro 7.471E-4 1.770E-3 7.777E-3 3.362E-2 1 2
20 PF00058 Ldl recept b Pfam 5.220E-3 1.094E-2 4.808E-2
2.349E-1
 1 14
21 PS51120 LDLRB PROSITE 5.220E-3 1.094E-2 4.808E-2
2.349E-1
 1 14
22 SM00135 LY SMART 5.592E-3 1.094E-2 4.808E-2
2.516E-1
 1 15
23 IPR000033 LDLR classB rpt InterPro 5.592E-3 1.094E-2 4.808E-2
2.516E-1
 1 15
24 SM00643 C345C SMART 6.335E-3 1.188E-2
5.221E-2
2.851E-1
 1 17
25 PF01759 NTR Pfam 7.079E-3 1.225E-2
5.384E-2
3.185E-1
 1 19
26 IPR018933 Netrin module non-TIMP InterPro 7.079E-3 1.225E-2
5.384E-2
3.185E-1
 1 19
27 PS50189 NTR PROSITE 8.563E-3 1.376E-2
6.049E-2
3.853E-1
 1 23
28 IPR001134 Netrin domain InterPro 8.563E-3 1.376E-2
6.049E-2
3.853E-1
 1 23
29 IPR008993 TIMP-like OB-fold InterPro 9.676E-3 1.501E-2
6.599E-2
4.354E-1
 1 26
30 2.120.10.30 - Gene3D 1.448E-2 2.151E-2
9.456E-2
6.517E-1
 1 39
31 IPR023415 LDLR class-A CS InterPro 1.485E-2 2.151E-2
9.456E-2
6.684E-1
 1 40
32 PF00057 Ldl recept a Pfam 1.670E-2 2.151E-2
9.456E-2
7.513E-1
 1 45
33 IPR011042 6-blade b-propeller TolB-like InterPro 1.706E-2 2.151E-2
9.456E-2
7.679E-1
 1 46
34 4.10.400.10 - Gene3D 1.706E-2 2.151E-2
9.456E-2
7.679E-1
 1 46
35 PS01209 LDLRA 1 PROSITE 1.780E-2 2.151E-2
9.456E-2
8.010E-1
 1 48
36 IPR002172 LDrepeatLR classA rpt InterPro 1.817E-2 2.151E-2
9.456E-2
8.176E-1
 1 49
37 SM00192 LDLa SMART 1.817E-2 2.151E-2
9.456E-2
8.176E-1
 1 49
38 PS50068 LDLRA 2 PROSITE 1.817E-2 2.151E-2
9.456E-2
8.176E-1
 1 49
Show 33 more annotations

7: Pathway [Display Chart] 7 input genes in category / 57 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5493 Genes related to Wnt-mediated signal transduction MSigDB C2 BIOCARTA (v6.0) 7.829E-13 4.463E-11 2.066E-10 4.463E-11 6 89
2 83061 Wnt signaling pathway BioSystems: KEGG 1.433E-11 4.085E-10 1.891E-9 8.170E-10 6 143
3 83113 Basal cell carcinoma BioSystems: KEGG 2.913E-11 5.536E-10 2.562E-9 1.661E-9 5 55
4 1269570 Class B/2 (Secretin family receptors) BioSystems: REACTOME 4.330E-10 6.171E-9 2.857E-8 2.468E-8 5 93
5 137962 Wnt signaling network BioSystems: Pathway Interaction Database 7.129E-10 8.127E-9 3.762E-8 4.063E-8 4 28
6 P00004 Alzheimer disease-presenilin pathway PantherDB 1.166E-9 1.108E-8 5.129E-8 6.649E-8 5 113
7 P00057 Wnt signaling pathway PantherDB 1.412E-9 1.150E-8 5.323E-8 8.049E-8 6 305
8 1435207 Breast cancer BioSystems: KEGG 3.980E-9 2.836E-8 1.313E-7 2.269E-7 5 144
9 83059 mTOR signaling pathway BioSystems: KEGG 5.059E-9 3.204E-8 1.483E-7 2.883E-7 5 151
10 1268924 RNF mutants show enhanced WNT signaling and proliferation BioSystems: REACTOME 9.130E-9 5.204E-8 2.409E-7 5.204E-7 3 9
11 782000 Proteoglycans in cancer BioSystems: KEGG 2.244E-8 1.163E-7 5.383E-7 1.279E-6 5 203
12 PW:0000200 the planar cell polarity Wnt signaling Pathway Ontology 4.938E-8 2.346E-7 1.086E-6 2.815E-6 3 15
13 1269611 PCP/CE pathway BioSystems: REACTOME 1.241E-7 5.440E-7 2.518E-6 7.072E-6 4 98
14 83092 Melanogenesis BioSystems: KEGG 1.402E-7 5.707E-7 2.642E-6 7.989E-6 4 101
15 1269607 Regulation of FZD by ubiquitination BioSystems: REACTOME 1.669E-7 6.341E-7 2.935E-6 9.511E-6 3 22
16 1269594 Signaling by Wnt BioSystems: REACTOME 2.962E-7 1.055E-6 4.885E-6 1.688E-5 5 340
17 1026136 Signaling pathways regulating pluripotency of stem cells BioSystems: KEGG 5.075E-7 1.701E-6 7.876E-6 2.893E-5 4 139
18 83105 Pathways in cancer BioSystems: KEGG 6.247E-7 1.978E-6 9.158E-6 3.561E-5 5 395
19 1268906 Signaling by WNT in cancer BioSystems: REACTOME 7.069E-7 2.016E-6 9.334E-6 4.029E-5 3 35
20 1269610 Beta-catenin independent WNT signaling BioSystems: REACTOME 7.075E-7 2.016E-6 9.334E-6 4.033E-5 4 151
21 749777 Hippo signaling pathway BioSystems: KEGG 7.656E-7 2.078E-6 9.620E-6 4.364E-5 4 154
22 P00012 Cadherin signaling pathway PantherDB 8.702E-7 2.255E-6 1.044E-5 4.960E-5 4 159
23 1269544 GPCR ligand binding BioSystems: REACTOME 1.261E-6 3.125E-6 1.446E-5 7.186E-5 5 455
24 1269615 Ca2+ pathway BioSystems: REACTOME 3.863E-6 9.174E-6 4.247E-5 2.202E-4 3 61
25 1269612 Asymmetric localization of PCP proteins BioSystems: REACTOME 5.613E-6 1.276E-5 5.908E-5 3.199E-4 3 69
26 373901 HTLV-I infection BioSystems: KEGG 5.822E-6 1.276E-5 5.908E-5 3.319E-4 4 256
27 1269599 TCF dependent signaling in response to WNT BioSystems: REACTOME 2.396E-4 5.059E-4 2.342E-3 1.366E-2 3 242
28 1268855 Diseases of signal transduction BioSystems: REACTOME 8.535E-4 1.738E-3 8.043E-3 4.865E-2 3 373
29 PW:0000321 altered Hedgehog signaling Pathway Ontology 1.124E-3 2.136E-3 9.888E-3
6.408E-2
 1 2
30 PW:0000122 Hedgehog signaling Pathway Ontology 1.124E-3 2.136E-3 9.888E-3
6.408E-2
 1 2
31 83065 Axon guidance BioSystems: KEGG 3.939E-3 7.242E-3 3.352E-2
2.245E-1
 2 175
32 1269613 WNT5A-dependent internalization of FZD4 BioSystems: REACTOME 8.405E-3 1.452E-2
6.721E-2
4.791E-1
 1 15
33 1269608 Negative regulation of TCF-dependent signaling by WNT ligand antagonists BioSystems: REACTOME 8.405E-3 1.452E-2
6.721E-2
4.791E-1
 1 15
34 M11792 Sonic Hedgehog (Shh) Pathway MSigDB C2 BIOCARTA (v6.0) 8.964E-3 1.503E-2
6.956E-2
5.109E-1
 1 16
35 1269642 Activation of SMO BioSystems: REACTOME 1.008E-2 1.641E-2
7.598E-2
5.745E-1
 1 18
36 P00025 Hedgehog signaling pathway PantherDB 1.064E-2 1.684E-2
7.796E-2
6.063E-1
 1 19
37 137950 Signaling events mediated by the Hedgehog family BioSystems: Pathway Interaction Database 1.231E-2 1.896E-2
8.776E-2
7.015E-1
 1 22
38 1268850 BBSome-mediated cargo-targeting to cilium BioSystems: REACTOME 1.286E-2 1.930E-2
8.932E-2
7.332E-1
 1 23
39 169354 Noncanonical Wnt signaling pathway BioSystems: Pathway Interaction Database 1.675E-2 2.406E-2
1.114E-1
9.548E-1
 1 30
40 138032 Canonical Wnt signaling pathway BioSystems: Pathway Interaction Database 1.730E-2 2.406E-2
1.114E-1
9.863E-1
 1 31
41 138064 Syndecan-4-mediated signaling events BioSystems: Pathway Interaction Database 1.730E-2 2.406E-2
1.114E-1
9.863E-1
 1 31
42 1269601 Disassembly of the destruction complex and recruitment of AXIN to the membrane BioSystems: REACTOME 1.786E-2 2.424E-2
1.122E-1
1.000E0
 1 32
43 137912 Hedgehog signaling events mediated by Gli proteins BioSystems: Pathway Interaction Database 2.448E-2 3.238E-2
1.499E-1
1.000E0
 1 44
44 PW:0000201 canonical Wnt signaling Pathway Ontology 2.558E-2 3.238E-2
1.499E-1
1.000E0
 1 46
45 137914 Presenilin action in Notch and Wnt signaling BioSystems: Pathway Interaction Database 2.558E-2 3.238E-2
1.499E-1
1.000E0
 1 46
46 83063 Hedgehog signaling pathway BioSystems: KEGG 2.613E-2 3.238E-2
1.499E-1
1.000E0
 1 47
47 1268848 Cargo trafficking to the periciliary membrane BioSystems: REACTOME 2.943E-2 3.569E-2
1.652E-1
1.000E0
 1 53
Show 42 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 1251 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12812787 A role for Wnt/beta-catenin signaling in lens epithelial differentiation. Pubmed 2.876E-19 3.597E-16 2.773E-15 3.597E-16 6 25
2 12412008 Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Pubmed 9.640E-19 6.030E-16 4.649E-15 1.206E-15 6 30
3 19562671 Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells. Pubmed 1.520E-17 6.339E-15 4.887E-14 1.902E-14 6 46
4 17064353 Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid. Pubmed 6.307E-16 1.973E-13 1.521E-12 7.890E-13 5 21
5 19515997 Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Pubmed 8.188E-16 2.049E-13 1.579E-12 1.024E-12 6 87
6 9096311 A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Pubmed 1.043E-15 2.174E-13 1.676E-12 1.305E-12 5 23
7 10395542 Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Pubmed 1.974E-15 3.528E-13 2.720E-12 2.470E-12 4 5
8 18800919 Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Pubmed 8.620E-15 1.348E-12 1.039E-11 1.078E-11 5 34
9 18635608 Tissue-specific requirements of beta-catenin in external genitalia development. Pubmed 1.168E-14 1.461E-12 1.126E-11 1.461E-11 5 36
10 15342465 Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Pubmed 1.168E-14 1.461E-12 1.126E-11 1.461E-11 5 36
11 21041481 Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals. Pubmed 1.555E-14 1.768E-12 1.363E-11 1.945E-11 5 38
12 10559494 Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis. Pubmed 2.763E-14 2.881E-12 2.221E-11 3.457E-11 4 8
13 18351675 Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos. Pubmed 4.749E-14 4.444E-12 3.426E-11 5.941E-11 5 47
14 9160667 A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Pubmed 4.973E-14 4.444E-12 3.426E-11 6.222E-11 4 9
15 15245425 Expression of Frizzled genes in developing and postnatal hair follicles. Pubmed 8.288E-14 6.480E-12 4.996E-11 1.037E-10 4 10
16 17532316 Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis. Pubmed 8.288E-14 6.480E-12 4.996E-11 1.037E-10 4 10
17 17582687 Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain. Pubmed 1.302E-13 8.575E-12 6.611E-11 1.629E-10 4 11
18 17576136 Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling. Pubmed 1.302E-13 8.575E-12 6.611E-11 1.629E-10 4 11
19 24860427 Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells. Pubmed 1.302E-13 8.575E-12 6.611E-11 1.629E-10 4 11
20 24431302 Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. Pubmed 2.359E-13 1.475E-11 1.137E-10 2.951E-10 5 64
21 21623369 Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Pubmed 1.529E-12 9.108E-11 7.022E-10 1.913E-9 4 19
22 8626800 A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. Pubmed 2.885E-12 1.569E-10 1.210E-9 3.609E-9 4 22
23 12815618 Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina. Pubmed 2.885E-12 1.569E-10 1.210E-9 3.609E-9 4 22
24 21731673 Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Pubmed 6.271E-12 3.269E-10 2.520E-9 7.845E-9 6 378
25 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 6.789E-12 3.397E-10 2.619E-9 8.492E-9 6 383
26 18364260 3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19). Pubmed 9.363E-12 4.505E-10 3.473E-9 1.171E-8 4 29
27 24151333 Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development. Pubmed 2.063E-11 9.560E-10 7.370E-9 2.581E-8 4 35
28 28813421 Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Pubmed 6.426E-11 2.871E-9 2.213E-8 8.039E-8 4 46
29 27510977 Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling. Pubmed 7.023E-11 3.030E-9 2.336E-8 8.786E-8 4 47
30 20802536 Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling. Pubmed 7.538E-11 3.143E-9 2.423E-8 9.429E-8 3 6
31 15370539 Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). Pubmed 1.319E-10 5.156E-9 3.975E-8 1.650E-7 3 7
32 15923619 Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Pubmed 1.319E-10 5.156E-9 3.975E-8 1.650E-7 3 7
33 26450967 Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation. Pubmed 1.445E-10 5.480E-9 4.224E-8 1.808E-7 4 56
34 15035989 Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Pubmed 2.110E-10 7.542E-9 5.815E-8 2.640E-7 3 8
35 19388021 Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Pubmed 2.110E-10 7.542E-9 5.815E-8 2.640E-7 3 8
36 10415363 Expression of Wnt signalling pathway genes during tooth development. Pubmed 6.216E-10 2.046E-8 1.578E-7 7.776E-7 3 11
37 22575959 ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Pubmed 6.216E-10 2.046E-8 1.578E-7 7.776E-7 3 11
38 18606138 Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Pubmed 6.216E-10 2.046E-8 1.578E-7 7.776E-7 3 11
39 15617677 Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Pubmed 1.714E-9 5.497E-8 4.238E-7 2.144E-6 3 15
40 25727890 Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall. Pubmed 2.561E-9 7.984E-8 6.155E-7 3.203E-6 3 17
41 17145500 PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Pubmed 2.616E-9 7.984E-8 6.155E-7 3.273E-6 4 114
42 23827310 Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia. Pubmed 8.655E-9 2.578E-7 1.987E-6 1.083E-5 3 25
43 17804636 Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections. Pubmed 1.101E-8 3.129E-7 2.412E-6 1.377E-5 3 27
44 19023080 Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Pubmed 1.101E-8 3.129E-7 2.412E-6 1.377E-5 3 27
45 24816679 Polymorphisms in FZD3 and FZD6 genes and risk of neural tube defects in a northern Han Chinese population. Pubmed 2.879E-8 7.664E-7 5.908E-6 3.602E-5 2 2
46 28253274 Planar cell polarity genes frizzled4 and frizzled6 exert patterning influence on arterial vessel morphogenesis. Pubmed 2.879E-8 7.664E-7 5.908E-6 3.602E-5 2 2
47 20450888 Melanocyte stem cells express receptors for canonical Wnt-signaling pathway on their surface. Pubmed 2.879E-8 7.664E-7 5.908E-6 3.602E-5 2 2
48 18351662 WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Pubmed 4.006E-8 1.044E-6 8.050E-6 5.012E-5 3 41
49 18234671 Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. Pubmed 8.637E-8 2.161E-6 1.666E-5 1.081E-4 2 3
50 16495441 The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. Pubmed 8.637E-8 2.161E-6 1.666E-5 1.081E-4 2 3
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 124 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ZNRF3 ZNRF3 interactions 1.081E-8 1.340E-6 7.240E-6 1.340E-6 3 13
2 int:VNN2 VNN2 interactions 3.717E-7 2.304E-5 1.245E-4 4.609E-5 3 40
3 int:WNT5A WNT5A interactions 5.414E-5 1.745E-3 9.424E-3 6.713E-3 2 29
4 int:MAGI3 MAGI3 interactions 5.799E-5 1.745E-3 9.424E-3 7.191E-3 2 30
5 int:WNT3A WNT3A interactions 7.035E-5 1.745E-3 9.424E-3 8.724E-3 2 33
6 int:DLG2 DLG2 interactions 1.829E-4 3.780E-3 2.042E-2 2.268E-2 2 53
7 int:EPN1 EPN1 interactions 3.195E-4 5.661E-3 3.058E-2 3.962E-2 2 70
8 int:UPK1A UPK1A interactions 4.278E-4 5.894E-3 3.184E-2
5.305E-2
 2 81
9 int:ADGRG5 ADGRG5 interactions 4.278E-4 5.894E-3 3.184E-2
5.305E-2
 2 81
10 int:SYNE4 SYNE4 interactions 5.636E-4 6.989E-3 3.775E-2
6.989E-2
 2 93
11 int:DLG1 DLG1 interactions 7.873E-4 8.170E-3 4.413E-2
9.762E-2
 2 110
12 int:KREMEN2 KREMEN2 interactions 7.907E-4 8.170E-3 4.413E-2
9.805E-2
 1 2
13 int:DKK2 DKK2 interactions 1.186E-3 1.131E-2
6.110E-2
1.470E-1
 1 3
14 int:TLNRD1 TLNRD1 interactions 1.581E-3 1.400E-2
7.563E-2
1.960E-1
 1 4
15 int:GIPC3 GIPC3 interactions 1.976E-3 1.633E-2
8.821E-2
2.450E-1
 1 5
16 int:CHST9 CHST9 interactions 2.370E-3 1.633E-2
8.821E-2
2.939E-1
 1 6
17 int:NDP NDP interactions 2.370E-3 1.633E-2
8.821E-2
2.939E-1
 1 6
18 int:TENT4A TENT4A interactions 2.370E-3 1.633E-2
8.821E-2
2.939E-1
 1 6
19 int:CAPRIN2 CAPRIN2 interactions 2.765E-3 1.714E-2
9.260E-2
3.429E-1
 1 7
20 int:GAS8 GAS8 interactions 2.765E-3 1.714E-2
9.260E-2
3.429E-1
 1 7
21 int:PTCH2 PTCH2 interactions 3.160E-3 1.781E-2
9.619E-2
3.918E-1
 1 8
22 int:WNT10B WNT10B interactions 3.160E-3 1.781E-2
9.619E-2
3.918E-1
 1 8
23 int:FZD8 FZD8 interactions 3.948E-3 1.957E-2
1.057E-1
4.896E-1
 1 10
24 int:KLRA1P KLRA1P interactions 3.948E-3 1.957E-2
1.057E-1
4.896E-1
 1 10
25 int:SMO SMO interactions 4.342E-3 1.957E-2
1.057E-1
5.384E-1
 1 11
26 int:PRSS37 PRSS37 interactions 4.736E-3 1.957E-2
1.057E-1
5.873E-1
 1 12
27 int:FZD3 FZD3 interactions 4.736E-3 1.957E-2
1.057E-1
5.873E-1
 1 12
28 int:RSPO2 RSPO2 interactions 4.736E-3 1.957E-2
1.057E-1
5.873E-1
 1 12
29 int:DLG4 DLG4 interactions 4.762E-3 1.957E-2
1.057E-1
5.904E-1
 2 274
30 int:FZD4 FZD4 interactions 5.524E-3 1.957E-2
1.057E-1
6.849E-1
 1 14
31 int:WNT7B WNT7B interactions 5.524E-3 1.957E-2
1.057E-1
6.849E-1
 1 14
32 int:FZD6 FZD6 interactions 5.524E-3 1.957E-2
1.057E-1
6.849E-1
 1 14
33 int:NPC1 NPC1 interactions 5.524E-3 1.957E-2
1.057E-1
6.849E-1
 1 14
34 int:ANTXR2 ANTXR2 interactions 5.524E-3 1.957E-2
1.057E-1
6.849E-1
 1 14
35 int:GIPC2 GIPC2 interactions 5.524E-3 1.957E-2
1.057E-1
6.849E-1
 1 14
36 int:B3GALNT2 B3GALNT2 interactions 6.311E-3 1.979E-2
1.069E-1
7.825E-1
 1 16
37 int:FZD5 FZD5 interactions 6.311E-3 1.979E-2
1.069E-1
7.825E-1
 1 16
38 int:WNT1 WNT1 interactions 6.311E-3 1.979E-2
1.069E-1
7.825E-1
 1 16
39 int:SFRP1 SFRP1 interactions 6.311E-3 1.979E-2
1.069E-1
7.825E-1
 1 16
40 int:PDZRN3 PDZRN3 interactions 6.704E-3 1.979E-2
1.069E-1
8.313E-1
 1 17
41 int:SERPINF1 SERPINF1 interactions 6.704E-3 1.979E-2
1.069E-1
8.313E-1
 1 17
42 int:FZD7 FZD7 interactions 6.704E-3 1.979E-2
1.069E-1
8.313E-1
 1 17
43 int:TMPRSS12 TMPRSS12 interactions 7.097E-3 2.047E-2
1.105E-1
8.800E-1
 1 18
44 int:SFRP4 SFRP4 interactions 8.276E-3 2.332E-2
1.260E-1
1.000E0
 1 21
45 int:RASD2 RASD2 interactions 8.668E-3 2.389E-2
1.290E-1
1.000E0
 1 22
46 int:FBN2 FBN2 interactions 9.061E-3 2.392E-2
1.292E-1
1.000E0
 1 23
47 int:ARRB2 ARRB2 interactions 9.401E-3 2.392E-2
1.292E-1
1.000E0
 2 389
48 int:DKK1 DKK1 interactions 9.453E-3 2.392E-2
1.292E-1
1.000E0
 1 24
49 int:SOST SOST interactions 9.453E-3 2.392E-2
1.292E-1
1.000E0
 1 24
50 int:TMEM17 TMEM17 interactions 9.968E-3 2.441E-2
1.319E-1
1.000E0
 2 401
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 8q22.3-q23.1 8q22.3-q23.1 2.020E-4 1.414E-3 3.666E-3 1.414E-3 1 1
2 11q14.2 11q14.2 3.227E-3 6.816E-3 1.767E-2 2.259E-2 1 16
3 7q32.3 7q32.3 3.630E-3 6.816E-3 1.767E-2 2.541E-2 1 18
4 8p21 8p21 4.032E-3 6.816E-3 1.767E-2 2.823E-2 1 20
5 7p14.1 7p14.1 5.441E-3 6.816E-3 1.767E-2 3.808E-2 1 27
6 2q33 2q33 5.843E-3 6.816E-3 1.767E-2 4.090E-2 1 29
7 12p13.2 12p13.2 9.655E-3 9.655E-3 2.503E-2
6.758E-2
 1 48
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 39 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$PITX2 Q2 V$PITX2 Q2 2.001E-4 7.806E-3 3.320E-2 7.806E-3 3 215

12: Gene Family [Display Chart] 7 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 286 G protein-coupled receptors, Class F frizzled genenames.org 5.840E-16 2.336E-15 4.867E-15 2.336E-15 5 11
2 733 Secreted frizzled-related proteins genenames.org 1.922E-3 3.845E-3 8.010E-3 7.690E-3 1 5
3 634 Low density lipoprotein receptors genenames.org 4.992E-3 6.656E-3 1.387E-2 1.997E-2 1 13

13: Coexpression [Display Chart] 7 input genes in category / 716 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M12112 Angiogenic markers up-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus). MSigDB C2: CGP Curated Gene Sets (v6.0) 8.584E-8 6.146E-5 4.396E-4 6.146E-5 4 165
2 17471573-Table2 Human Viral Santegoets07 103genes GeneSigDB 1.840E-6 6.589E-4 4.712E-3 1.318E-3 3 88
3 M2121 Genes correlated with classical type of glioblastoma multiforme tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.155E-5 2.757E-3 1.972E-2 8.272E-3 3 162
4 15897907-SuppTable5 Human Breast Farmer05 269genes basal apocrine luminal GeneSigDB 4.641E-5 8.307E-3
5.941E-2
 3.323E-2 3 258
5 M15694 Down-regulated genes characteristic for autonomous thyroid adenoma. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.156E-4 1.535E-2
1.098E-1
8.279E-2
 2 55
6 M1758 Wnt target genes up-regulated after Cre-lox knockout of APC [GeneID=324] in the small intestine that require functional MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.287E-4 1.535E-2
1.098E-1
9.212E-2
 2 58
7 M2029 Genes down-regulated in NCI-H1299 cells (large cell neuroendocrine carcinoma) stably expressing SEMA3B [GeneID=7869]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.834E-4 1.876E-2
1.341E-1
1.313E-1
 3 410
8 19861896-Table2 Human Brain Castells09 83genes GeneSigDB 2.097E-4 1.877E-2
1.342E-1
1.502E-1
 2 74
9 17823238-TableS5 Human EmbryonicStemCell Soh07 469genes GeneSigDB 2.608E-4 2.075E-2
1.484E-1
1.867E-1
 3 462
10 17178894-Table1 Human Breast Fan06 104genes GeneSigDB 4.062E-4 2.908E-2
2.080E-1
2.908E-1
 2 103
11 18308945-Table4 Human StemCell Huang08 120genes GeneSigDB 4.886E-4 3.180E-2
2.275E-1
3.498E-1
 2 113
12 M5825 Angiogenic markers down-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.273E-4 3.505E-2
2.506E-1
5.207E-1
 2 138
13 M1124 Pubertal genes up-regulated by TGFB1 [GeneID=7040]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.087E-3 3.505E-2
2.506E-1
7.785E-1
 2 169
14 M8519 Genes down-regulated in mARMS (molecular ARMS) compared to the mERMS (molecular ERMS) class of rhabdomyosarcoma tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.259E-3 3.505E-2
2.506E-1
9.016E-1
 2 182
15 M1911 Genes up-regulated in mast cells (MC) after stimulation with a bacterial lipopolysaccharide (LPS). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.273E-3 3.505E-2
2.506E-1
9.114E-1
 2 183
16 M9241 Genes up-regulated in dendritic cells: 2,4-dinitrofluorobenzene (DNFB) [PubChem=6264] versus diphenyleneiodonium (DPI) [PubChem=2733504]. MSigDB C7: Immunologic Signatures (v6.0) 1.429E-3 3.505E-2
2.506E-1
1.000E0
 2 194
17 M4674 Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus CD4 [GeneID=920] effector memory T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.443E-3 3.505E-2
2.506E-1
1.000E0
 2 195
18 M4985 Genes up-regulated in comparison of B cells from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.488E-3 3.505E-2
2.506E-1
1.000E0
 2 198
19 M6209 Genes up-regulated in polymorphonuclear leukocytes (1.5h): control versus infection by A. phagocytophilum. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.505E-2
2.506E-1
1.000E0
 2 199
20 M4390 Genes down-regulated in comparison of dendritic cells (DC) treated with immunosuppressive DNA versus the untreated cells. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.505E-2
2.506E-1
1.000E0
 2 199
21 M3641 Genes up-regulated in comparison of unstimulated CD8 T cells at 72 h versus CD8 T cells at 72 h after stimulation with antigen-B7-1. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.505E-2
2.506E-1
1.000E0
 2 199
22 M4775 Genes up-regulated in comparison of lineage negative versus CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.505E-2
2.506E-1
1.000E0
 2 199
23 M8424 Genes down-regulated in B lymphocytes: systemic lupus erythematosous (SLE) versus healthy. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.505E-2
2.506E-1
1.000E0
 2 199
24 M7480 Genes down-regulated in periperal blood monocytes (PBMC): tolerant kidney transplants versus healthy controls. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.505E-2
2.506E-1
1.000E0
 2 200
25 M9644 Genes down-regulated in CD4 [GeneID=920] T helper cells (10h): Th0 versus TGFB1 and IL6 [GeneID=7040;3569]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.505E-2
2.506E-1
1.000E0
 2 200
26 M9662 Genes down-regulated in CD4 [GeneID=920] T helper cells Th0: 1h versus 20h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.505E-2
2.506E-1
1.000E0
 2 200
27 M296 Genes up-regulated in allogeneic T cells after stimulation with dendritic cells from: peripheral lymph nodes (mLN) versus spleen. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.505E-2
2.506E-1
1.000E0
 2 200
28 M4886 Genes up-regulated in comparison of follicular B cells versus late germinal center (GC) B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.505E-2
2.506E-1
1.000E0
 2 200
29 M3937 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 2 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.505E-2
2.506E-1
1.000E0
 2 200
30 M293 Genes up-regulated in allogeneic T cells after stimulation with dendritic cells from: mesenteric lymph nodes (mLN) versus spleen. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.505E-2
2.506E-1
1.000E0
 2 200
31 M320 Genes up-regulated in IRF4 and IRF8 [GeneID=3662;3394] null pre-B cell treated with 5ng/ml IL7 [GeneID=3574] versus those transduced with IRF4 [GeneID=3662]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.505E-2
2.506E-1
1.000E0
 2 200
32 18698033-tableS1-AURKA Human Breast Desmedt08 229genes AURKA Module GeneSigDB 1.832E-3 3.974E-2
2.842E-1
1.000E0
 2 220
33 20156340-GENIUS-ERposHER2neg signature Human Breast HaibeKains10 229genes GENIUS ERposHER2neg GeneSigDB 1.832E-3 3.974E-2
2.842E-1
1.000E0
 2 220
34 M904 Up-regulated genes that vary between HNSCC (head and neck squamous cell carcinoma) groups formed on the basis of their level of pathological differentiation: well vs poorly differentiated tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.103E-3 4.289E-2
3.067E-1
1.000E0
 2 236
35 16455817-Figure1C Mouse Ovarian HernandezGonzalez06 07genes NoChange8-16Hr GeneSigDB 2.116E-3 4.289E-2
3.067E-1
1.000E0
 1 7
36 19286929-SuppTable2n Mouse Lung Rangasamy09 254genes GeneSigDB 2.156E-3 4.289E-2
3.067E-1
1.000E0
 2 239
37 M13398 Genes with low to medium basal transcription state in undifferentiated embryonic carcinoma cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.418E-3 4.445E-2
3.179E-1
1.000E0
 1 8
38 M1194 Genes regulated by CTNNB1 [GeneID=1499] and whose promoters contain binding sites for LEF1 [GeneID=51176]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.418E-3 4.445E-2
3.179E-1
1.000E0
 1 8
39 16166195-TableS1b Mouse Testicular Denolet06 342genes GeneSigDB 2.431E-3 4.445E-2
3.179E-1
1.000E0
 2 254
40 M2255 Genes commonly up-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.526E-3 4.445E-2
3.179E-1
1.000E0
 2 259
41 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.545E-3 4.445E-2
3.179E-1
1.000E0
 2 260
42 16470729-Table1 Human Development Farina06 10genes GeneSigDB 2.720E-3 4.637E-2
3.316E-1
1.000E0
 1 9
43 M9172 Genes down-regulated in primary keratinocytes at 1 h after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.022E-3 4.918E-2
3.517E-1
1.000E0
 1 10
44 M9371 Top genes up-regulated in colon epithelium biopsies from FAP (familial adenomatous polyposis) patients with mutated APC [GeneID=324]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.022E-3 4.918E-2
3.517E-1
1.000E0
 1 10
Show 39 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 492 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Sample Type by Project: Shred 1/TCGA-Cervix/Cervical Carcinoma/Cervical Squamous Cell Carcinoma/3/4 Sample Type by Project: Shred 1/TCGA-Cervix/Cervical Carcinoma/Cervical Squamous Cell Carcinoma/3/4 TCGA-Cervix 1.972E-6 9.702E-4 6.575E-3 9.702E-4 3 85
2 gudmap kidney e10.5 UretericTrunk HoxB7 k2 500 kidney e10.5 UretericTrunk HoxB7 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.298E-4 2.471E-2
1.674E-1
6.388E-2
 2 55
3 gudmap kidney P3 CapMes Crym 500 kidney P3 CapMes Crym top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.607E-4 2.471E-2
1.674E-1
7.908E-2
 3 370
4 gudmap kidney P4 CapMesRenVes Crym 500 kidney P4 CapMesRenVes Crym top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.009E-4 2.471E-2
1.674E-1
9.883E-2
 3 399
5 gudmap kidney e10.5 UretericTrunk HoxB7 k3 1000 kidney e10.5 UretericTrunk HoxB7 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.719E-4 3.182E-2
2.156E-1
1.830E-1
 2 93
6 gudmap kidney P4 CapMesRenVes Crym k4 500 kidney P4 CapMesRenVes Crym k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.880E-4 3.182E-2
2.156E-1
1.909E-1
 2 95
7 Sample Type by Project: Shred 1/TCGA-Head and Neck/Head and Neck Carcinoma/Squamous Cell Carcinoma/3/0 Sample Type by Project: Shred 1/TCGA-Head and Neck/Head and Neck Carcinoma/Squamous Cell Carcinoma/3/0 TCGA-Head and Neck 6.079E-4 4.273E-2
2.895E-1
2.991E-1
 2 119
Show 2 more annotations

15: Computational [Display Chart] 5 input genes in category / 18 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 7 input genes in category / 396 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-125b-5p:Functional MTI Functional MTI miRTarbase 7.251E-6 1.155E-3 7.578E-3 2.871E-3 3 431
2 hsa-miR-582-5p:TargetScan hsa-miR-582-5p TargetScan 8.638E-6 1.155E-3 7.578E-3 3.421E-3 3 457
3 hsa-miR-377:PITA hsa-miR-377:PITA TOP PITA 8.752E-6 1.155E-3 7.578E-3 3.466E-3 3 459
4 hsa-miR-671-5p:PITA hsa-miR-671-5p:PITA TOP PITA 6.812E-5 3.875E-3 2.542E-2 2.698E-2 2 131
5 ACACTGG,MIR-199B:MSigDB ACACTGG,MIR-199B:MSigDB MSigDB 8.347E-5 3.875E-3 2.542E-2 3.305E-2 2 145
6 ACACTGG,MIR-199A:MSigDB ACACTGG,MIR-199A:MSigDB MSigDB 8.347E-5 3.875E-3 2.542E-2 3.305E-2 2 145
7 hsa-miR-629:PITA hsa-miR-629:PITA TOP PITA 9.293E-5 3.875E-3 2.542E-2 3.680E-2 2 153
8 hsa-miR-208b-3p:TargetScan hsa-miR-208b-3p TargetScan 1.042E-4 3.875E-3 2.542E-2 4.126E-2 2 162
9 hsa-miR-208a-3p:TargetScan hsa-miR-208a-3p TargetScan 1.042E-4 3.875E-3 2.542E-2 4.126E-2 2 162
10 hsa-miR-199a-5p:Non-Functional MTI Non-Functional MTI miRTarbase 1.094E-4 3.875E-3 2.542E-2 4.332E-2 2 166
11 hsa-miR-651:PITA hsa-miR-651:PITA TOP PITA 1.134E-4 3.875E-3 2.542E-2 4.490E-2 2 169
12 hsa-miR-219-5p:PITA hsa-miR-219-5p:PITA TOP PITA 1.174E-4 3.875E-3 2.542E-2 4.650E-2 2 172
13 hsa-miR-584:PITA hsa-miR-584:PITA TOP PITA 1.358E-4 4.137E-3 2.714E-2
5.379E-2
 2 185
14 hsa-miR-508-5p:PITA hsa-miR-508-5p:PITA TOP PITA 1.524E-4 4.311E-3 2.828E-2
6.036E-2
 2 196
15 hsa-miR-338-3p:PITA hsa-miR-338-3p:PITA TOP PITA 1.867E-4 4.930E-3 3.234E-2
7.395E-2
 2 217
16 hsa-miR-145-5p:Functional MTI Functional MTI miRTarbase 2.245E-4 5.407E-3 3.547E-2
8.891E-2
 2 238
17 GTACTGT,MIR-101:MSigDB GTACTGT,MIR-101:MSigDB MSigDB 2.321E-4 5.407E-3 3.547E-2
9.191E-2
 2 242
18 hsa-miR-29c-3p:Functional MTI Functional MTI miRTarbase 2.556E-4 5.424E-3 3.558E-2
1.012E-1
 2 254
19 hsa-miR-590-5p:PITA hsa-miR-590-5p:PITA TOP PITA 2.698E-4 5.424E-3 3.558E-2
1.068E-1
 2 261
20 hsa-miR-21:PITA hsa-miR-21:PITA TOP PITA 2.740E-4 5.424E-3 3.558E-2
1.085E-1
 2 263
21 hsa-miR-767-5p:PITA hsa-miR-767-5p:PITA TOP PITA 3.081E-4 5.811E-3 3.812E-2
1.220E-1
 2 279
22 hsa-miR-499a-5p:TargetScan hsa-miR-499a-5p TargetScan 3.898E-4 7.017E-3 4.603E-2
1.544E-1
 2 314
23 hsa-miR-31-5p:TargetScan hsa-miR-31-5p TargetScan 4.460E-4 7.667E-3
5.029E-2
1.766E-1
 2 336
24 hsa-miR-153:PITA hsa-miR-153:PITA TOP PITA 4.647E-4 7.667E-3
5.029E-2
1.840E-1
 2 343
25 hsa-miR-145:PITA hsa-miR-145:PITA TOP PITA 6.337E-4 9.575E-3
6.281E-2
2.509E-1
 2 401
26 hsa-miR-450a:mirSVR lowEffct hsa-miR-450a:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 6.431E-4 9.575E-3
6.281E-2
2.547E-1
 2 404
27 hsa-miR-205-5p:TargetScan hsa-miR-205-5p TargetScan 6.913E-4 9.575E-3
6.281E-2
2.738E-1
 2 419
28 hsa-miR-199a-5p:TargetScan hsa-miR-199a-5p TargetScan 7.012E-4 9.575E-3
6.281E-2
2.777E-1
 2 422
29 hsa-miR-199b-5p:TargetScan hsa-miR-199b-5p TargetScan 7.012E-4 9.575E-3
6.281E-2
2.777E-1
 2 422
30 hsa-miR-452:PITA hsa-miR-452:PITA TOP PITA 7.999E-4 9.986E-3
6.551E-2
3.168E-1
 2 451
31 hsa-miR-1264:PITA hsa-miR-1264:PITA TOP PITA 8.070E-4 9.986E-3
6.551E-2
3.196E-1
 2 453
32 hsa-miR-103a-3p:Non-Functional MTI Non-Functional MTI miRTarbase 8.070E-4 9.986E-3
6.551E-2
3.196E-1
 2 453
33 hsa-miR-101:PITA hsa-miR-101:PITA TOP PITA 9.013E-4 1.082E-2
7.095E-2
3.569E-1
 2 479
34 hsa-miR-487b-3p:TargetScan hsa-miR-487b-3p TargetScan 1.065E-3 1.241E-2
8.140E-2
4.219E-1
 1 11
35 hsa-miR-126-3p.1:TargetScan hsa-miR-126-3p.1 TargetScan 2.323E-3 2.629E-2
1.724E-1
9.200E-1
 1 24
36 hsa-miR-628-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.903E-3 3.107E-2
2.038E-1
1.000E0
 1 30
37 hsa-miR-487b:PITA hsa-miR-487b:PITA TOP PITA 2.903E-3 3.107E-2
2.038E-1
1.000E0
 1 30
38 hsa-miR-5092:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.193E-3 3.328E-2
2.183E-1
1.000E0
 1 33
39 hsa-miR-487a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.676E-3 3.676E-2
2.411E-1
1.000E0
 1 38
40 GGCAGAC,MIR-346:MSigDB GGCAGAC,MIR-346:MSigDB MSigDB 3.773E-3 3.676E-2
2.411E-1
1.000E0
 1 39
41 hsa-miR-487b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 3.676E-2
2.411E-1
1.000E0
 1 40
42 hsa-miR-6826-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.966E-3 3.676E-2
2.411E-1
1.000E0
 1 41
43 hsa-miR-7158-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.546E-3 3.676E-2
2.411E-1
1.000E0
 1 47
44 hsa-miR-3138:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.546E-3 3.676E-2
2.411E-1
1.000E0
 1 47
45 hsa-miR-7161-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.932E-3 3.676E-2
2.411E-1
1.000E0
 1 51
46 hsa-miR-600:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.028E-3 3.676E-2
2.411E-1
1.000E0
 1 52
47 hsa-miR-4506:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.125E-3 3.676E-2
2.411E-1
1.000E0
 1 53
48 hsa-miR-6755-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.125E-3 3.676E-2
2.411E-1
1.000E0
 1 53
49 hsa-miR-6806-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 3.676E-2
2.411E-1
1.000E0
 1 54
50 hsa-miR-5094:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.317E-3 3.676E-2
2.411E-1
1.000E0
 1 55
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 2275 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000014025 A 172 Stitch 2.811E-9 6.395E-6 5.312E-5 6.395E-6 4 70
2 CID000003804 Prestwick 517 Stitch 1.517E-8 1.726E-5 1.434E-4 3.451E-5 4 106
3 CID004630071 AC1NDQQF Stitch 2.660E-7 1.660E-4 1.379E-3 6.052E-4 3 46
4 CID000448615 AC1L9M5J Stitch 2.918E-7 1.660E-4 1.379E-3 6.639E-4 4 221
5 ctd:D018021 Lithium Chloride CTD 1.430E-6 6.505E-4 5.404E-3 3.253E-3 4 329
6 CID000020138 butenal Stitch 1.646E-5 3.947E-3 3.279E-2 3.744E-2 3 180
7 5743 DN Cycloheximide [66-81-9]; Down 200; 14.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.673E-5 3.947E-3 3.279E-2 3.807E-2 3 181
8 2208 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.875E-5 3.947E-3 3.279E-2 4.265E-2 3 188
9 5066 DN Diethylcarbamazine citrate [1642-54-2]; Down 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.156E-5 3.947E-3 3.279E-2 4.905E-2 3 197
10 7006 UP Etodolac [41340-25-4]; Up 200; 14uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.189E-5 3.947E-3 3.279E-2 4.980E-2 3 198
11 7240 DN Quipazine dimaleate salt [4774-24-7]; Down 200; 9uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.189E-5 3.947E-3 3.279E-2 4.980E-2 3 198
12 7233 DN Isopyrin hydrochloride [18342-39-7]; Down 200; 14.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.222E-5 3.947E-3 3.279E-2
5.055E-2
 3 199
13 6766 UP Dipivefrin hydrochloride [64019-93-8]; Up 200; 10.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.256E-5 3.947E-3 3.279E-2
5.131E-2
 3 200
14 CID000017570 4,4'-thiodiphenol Stitch 3.976E-5 6.461E-3
5.367E-2
9.045E-2
 2 32
15 CID000002794 clofazimine Stitch 4.767E-5 7.230E-3
6.006E-2
1.085E-1
 2 35
16 CID000081248 12 p Stitch 5.767E-5 8.200E-3
6.812E-2
1.312E-1
 3 274
17 CID003003791 methallibure Stitch 6.564E-5 8.784E-3
7.297E-2
1.493E-1
 2 41
18 CID000007813 p-toluidine Stitch 1.981E-4 2.255E-2
1.874E-1
4.506E-1
 2 71
19 CID000130938 N-p-carboxybenzyl-D-glucamine dithiocarbamate Stitch 3.065E-4 2.255E-2
1.874E-1
6.972E-1
 1 1
20 ctd:D003005 Clopamide CTD 3.065E-4 2.255E-2
1.874E-1
6.972E-1
 1 1
21 CID000163065 Bassianolide Stitch 3.065E-4 2.255E-2
1.874E-1
6.972E-1
 1 1
22 CID003081178 DiADMS Stitch 3.065E-4 2.255E-2
1.874E-1
6.972E-1
 1 1
23 ctd:C004639 cyclothiazide CTD 3.065E-4 2.255E-2
1.874E-1
6.972E-1
 1 1
24 ctd:C009166 retinol acetate CTD 3.546E-4 2.255E-2
1.874E-1
8.068E-1
 2 95
25 CID000023039 Alstonine hydrochloride Stitch 5.281E-4 2.255E-2
1.874E-1
1.000E0
 2 116
26 CID000283393 triphenodioxazine Stitch 6.129E-4 2.255E-2
1.874E-1
1.000E0
 1 2
27 CID000038283 cyphenothrin Stitch 6.129E-4 2.255E-2
1.874E-1
1.000E0
 1 2
28 ctd:C468920 SANT-2 compound CTD 6.129E-4 2.255E-2
1.874E-1
1.000E0
 1 2
29 ctd:C493177 4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide CTD 9.192E-4 2.255E-2
1.874E-1
1.000E0
 1 3
30 CID003082684 BTHP Stitch 9.192E-4 2.255E-2
1.874E-1
1.000E0
 1 3
31 ctd:C470893 purmorphamine CTD 9.192E-4 2.255E-2
1.874E-1
1.000E0
 1 3
32 ctd:C468918 SAG compound CTD 9.192E-4 2.255E-2
1.874E-1
1.000E0
 1 3
33 6817 DN Verteporfin [129497-78-5]; Down 200; 2.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 9.396E-4 2.255E-2
1.874E-1
1.000E0
 2 155
34 CID000020518 11-deoxojervine Stitch 1.209E-3 2.255E-2
1.874E-1
1.000E0
 2 176
35 ctd:D000092 Acetohexamide CTD 1.225E-3 2.255E-2
1.874E-1
1.000E0
 1 4
36 CID000018980 phthalogen Stitch 1.225E-3 2.255E-2
1.874E-1
1.000E0
 1 4
37 2757 DN Piperlongumine [20069-09-4]; Down 200; 12.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.236E-3 2.255E-2
1.874E-1
1.000E0
 2 178
38 4651 DN Cephaeline dihydrochloride heptahydrate [6487-30-5]; Down 200; 6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.250E-3 2.255E-2
1.874E-1
1.000E0
 2 179
39 1477 UP Miconazole [22916-47-8]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.264E-3 2.255E-2
1.874E-1
1.000E0
 2 180
40 3106 DN Chrysin [480-40-0]; Down 200; 15.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.278E-3 2.255E-2
1.874E-1
1.000E0
 2 181
41 6764 DN Anisomycin [22862-76-6]; Down 200; 15uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.363E-3 2.255E-2
1.874E-1
1.000E0
 2 187
42 595 UP resveratrol; Up 200; 50uM; MCF7; HG-U133A Broad Institute CMAP Up 1.406E-3 2.255E-2
1.874E-1
1.000E0
 2 190
43 7154 DN Eburnamonine (-) [4880-88-0]; Down 200; 13.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.421E-3 2.255E-2
1.874E-1
1.000E0
 2 191
44 7549 DN CP-944629 [668990-94-1]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.421E-3 2.255E-2
1.874E-1
1.000E0
 2 191
45 5401 DN Dextromethorphan hydrobromide monohydrate [6700-34-1]; Down 200; 10.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.436E-3 2.255E-2
1.874E-1
1.000E0
 2 192
46 1337 UP Bacampicillin hydrochloride [37661-08-8]; Up 200; 8uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.436E-3 2.255E-2
1.874E-1
1.000E0
 2 192
47 1211 UP retinoic acid; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.436E-3 2.255E-2
1.874E-1
1.000E0
 2 192
48 7427 DN Econazole nitrate [24169-02-6]; Down 200; 9uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.451E-3 2.255E-2
1.874E-1
1.000E0
 2 193
49 4846 DN Quercetine dihydrate [6151-25-3]; Down 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.451E-3 2.255E-2
1.874E-1
1.000E0
 2 193
50 5498 UP Dapsone [80-08-0]; Up 200; 16.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.465E-3 2.255E-2
1.874E-1
1.000E0
 2 194
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 208 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0027794 Neural Tube Defects DisGeNET Curated 3.093E-5 6.433E-3 3.807E-2 6.433E-3 3 158
2 C0812413 Malignant Pleural Mesothelioma DisGeNET BeFree 1.394E-4 8.168E-3 4.833E-2 2.899E-2 3 262
3 C1535939 Pneumocystis jiroveci pneumonia DisGeNET BeFree 3.386E-4 8.168E-3 4.833E-2
7.043E-2
 2 66
4 C0039075 Syndactyly DisGeNET Curated 4.030E-4 8.168E-3 4.833E-2
8.382E-2
 2 72
5 OMIN:610947 CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2; ADCAD2 OMIM 4.320E-4 8.168E-3 4.833E-2
8.985E-2
 1 1
6 C3279974 NAIL DISORDER, NONSYNDROMIC CONGENITAL, 10 DisGeNET Curated 4.320E-4 8.168E-3 4.833E-2
8.985E-2
 1 1
7 cv:C3279974 Nail disorder, nonsyndromic congenital, 10 Clinical Variations 4.320E-4 8.168E-3 4.833E-2
8.985E-2
 1 1
8 C1970440 CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2 (disorder) DisGeNET Curated 4.320E-4 8.168E-3 4.833E-2
8.985E-2
 1 1
9 cv:C1970440 Coronary artery disease, autosomal dominant 2 Clinical Variations 4.320E-4 8.168E-3 4.833E-2
8.985E-2
 1 1
10 C4225231 TOOTH AGENESIS, SELECTIVE, 7 DisGeNET Curated 4.320E-4 8.168E-3 4.833E-2
8.985E-2
 1 1
11 C0795915 Winter Shortland Temple syndrome DisGeNET Curated 4.320E-4 8.168E-3 4.833E-2
8.985E-2
 1 1
12 C0026683 Mucocele DisGeNET BeFree 8.638E-4 9.456E-3
5.595E-2
1.797E-1
 1 2
13 C0266559 Persistent primary vitreous DisGeNET BeFree 8.638E-4 9.456E-3
5.595E-2
1.797E-1
 1 2
14 OMIN:133780 EXUDATIVE VITREORETINOPATHY 1; EVR1 OMIM 8.638E-4 9.456E-3
5.595E-2
1.797E-1
 1 2
15 C0024954 Maxillary Neoplasms DisGeNET Curated 8.638E-4 9.456E-3
5.595E-2
1.797E-1
 1 2
16 C0263536 Hypertrophy of nail DisGeNET Curated 8.638E-4 9.456E-3
5.595E-2
1.797E-1
 1 2
17 cv:C1851402 Familial exudative vitreoretinopathy Clinical Variations 8.638E-4 9.456E-3
5.595E-2
1.797E-1
 1 2
18 C0423361 Posterior Vitreous Detachment DisGeNET Curated 8.638E-4 9.456E-3
5.595E-2
1.797E-1
 1 2
19 C1851406 Peripheral retinal avascularization DisGeNET Curated 8.638E-4 9.456E-3
5.595E-2
1.797E-1
 1 2
20 C0344550 Congenital retinal fold DisGeNET Curated 1.295E-3 1.283E-2
7.592E-2
2.694E-1
 1 3
21 C0035320 Retinal Neovascularization DisGeNET Curated 1.295E-3 1.283E-2
7.592E-2
2.694E-1
 1 3
22 C0010278 Craniosynostosis DisGeNET Curated 1.688E-3 1.562E-2
9.241E-2
3.512E-1
 2 148
23 C4072980 Exudative vitreoretinopathy DisGeNET Curated 1.727E-3 1.562E-2
9.241E-2
3.592E-1
 1 4
24 C1654637 androgen independent prostate cancer DisGeNET BeFree 2.043E-3 1.603E-2
9.487E-2
4.249E-1
 2 163
25 C1850109 Vitreoretinal abnormalities DisGeNET Curated 2.158E-3 1.603E-2
9.487E-2
4.489E-1
 1 5
26 C1851402 Exudative vitreoretinopathy 1 DisGeNET Curated 2.158E-3 1.603E-2
9.487E-2
4.489E-1
 1 5
27 C0339383 Choroidal and/or chorioretinal disorder DisGeNET BeFree 2.158E-3 1.603E-2
9.487E-2
4.489E-1
 1 5
28 C3279947 NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9 DisGeNET BeFree 2.158E-3 1.603E-2
9.487E-2
4.489E-1
 1 5
29 C0085661 Onycholysis DisGeNET Curated 2.589E-3 1.683E-2
9.959E-2
5.386E-1
 1 6
30 C0751676 Basal Cell Cancer DisGeNET BeFree 2.589E-3 1.683E-2
9.959E-2
5.386E-1
 1 6
31 C0334486 Low Grade Endometrial Stromal Sarcoma DisGeNET BeFree 2.589E-3 1.683E-2
9.959E-2
5.386E-1
 1 6
32 C0042909 Vitreous Hemorrhage DisGeNET Curated 2.589E-3 1.683E-2
9.959E-2
5.386E-1
 1 6
33 C1319016 Nephrogenic rest, intralobar DisGeNET BeFree 3.020E-3 1.848E-2
1.093E-1
6.282E-1
 1 7
34 C0271055 Rhegmatogenous retinal detachment DisGeNET Curated 3.020E-3 1.848E-2
1.093E-1
6.282E-1
 1 7
35 C0266568 Persistent Hyperplastic Primary Vitreous DisGeNET Curated 3.451E-3 2.051E-2
1.214E-1
7.179E-1
 1 8
36 C0235259 Subcapsular cataract DisGeNET Curated 3.882E-3 2.070E-2
1.225E-1
8.074E-1
 1 9
37 C1395852 Polydactyly preaxial type 1 DisGeNET Curated 3.882E-3 2.070E-2
1.225E-1
8.074E-1
 1 9
38 C0005754 Congenital blindness DisGeNET Curated 3.882E-3 2.070E-2
1.225E-1
8.074E-1
 1 9
39 C0022360 Jaw Abnormalities DisGeNET Curated 3.882E-3 2.070E-2
1.225E-1
8.074E-1
 1 9
40 C1833999 Pigmentary retinal degeneration DisGeNET Curated 4.743E-3 2.349E-2
1.390E-1
9.865E-1
 1 11
41 C0240897 Retinal exudates DisGeNET Curated 4.743E-3 2.349E-2
1.390E-1
9.865E-1
 1 11
42 C0751291 Desmoplastic Medulloblastoma DisGeNET Curated 4.743E-3 2.349E-2
1.390E-1
9.865E-1
 1 11
43 C0007113 Rectal Carcinoma DisGeNET BeFree 5.106E-3 2.378E-2
1.407E-1
1.000E0
 2 260
44 C1274103 Oncogenic osteomalacia DisGeNET BeFree 5.173E-3 2.378E-2
1.407E-1
1.000E0
 1 12
45 C0262374 Stricture of anus DisGeNET Curated 5.603E-3 2.378E-2
1.407E-1
1.000E0
 1 13
46 C0265294 Pyle metaphyseal dysplasia DisGeNET Curated 5.603E-3 2.378E-2
1.407E-1
1.000E0
 1 13
47 C0154832 Exudative retinopathy DisGeNET Curated 5.603E-3 2.378E-2
1.407E-1
1.000E0
 1 13
48 C0282201 Phosphate Diabetes DisGeNET BeFree 5.603E-3 2.378E-2
1.407E-1
1.000E0
 1 13
49 C0339539 Familial Exudative Vitreoretinopathy DisGeNET Curated 5.603E-3 2.378E-2
1.407E-1
1.000E0
 1 13
50 C0158734 Polydactyly of toes DisGeNET Curated 6.033E-3 2.461E-2
1.456E-1
1.000E0
 1 14
Show 45 more annotations