Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc379_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 33 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005201 extracellular matrix structural constituent 1.711E-4 4.421E-3 1.808E-2 5.646E-3 2 78
2 GO:0035375 zymogen binding 2.679E-4 4.421E-3 1.808E-2 8.842E-3 1 1
3 GO:0032190 acrosin binding 1.339E-3 1.473E-2
6.023E-2
 4.419E-2 1 5
4 GO:0019531 oxalate transmembrane transporter activity 2.944E-3 1.863E-2
7.618E-2
9.716E-2
 1 11
5 GO:0008271 secondary active sulfate transmembrane transporter activity 3.479E-3 1.863E-2
7.618E-2
1.148E-1
 1 13
6 GO:0015116 sulfate transmembrane transporter activity 3.746E-3 1.863E-2
7.618E-2
1.236E-1
 1 14
7 GO:0008329 signaling pattern recognition receptor activity 4.547E-3 1.863E-2
7.618E-2
1.501E-1
 1 17
8 GO:0038187 pattern recognition receptor activity 4.547E-3 1.863E-2
7.618E-2
1.501E-1
 1 17
9 GO:0015106 bicarbonate transmembrane transporter activity 5.081E-3 1.863E-2
7.618E-2
1.677E-1
 1 19
10 GO:1901682 sulfur compound transmembrane transporter activity 7.747E-3 2.169E-2
8.870E-2
2.556E-1
 1 29
11 GO:0015301 anion:anion antiporter activity 7.747E-3 2.169E-2
8.870E-2
2.556E-1
 1 29
12 GO:0005310 dicarboxylic acid transmembrane transporter activity 8.279E-3 2.169E-2
8.870E-2
2.732E-1
 1 31
13 GO:0030507 spectrin binding 8.546E-3 2.169E-2
8.870E-2
2.820E-1
 1 32
14 GO:0005044 scavenger receptor activity 1.253E-2 2.954E-2
1.208E-1
4.135E-1
 1 47
15 GO:0099516 ion antiporter activity 1.465E-2 3.223E-2
1.318E-1
4.835E-1
 1 55
16 GO:0048306 calcium-dependent protein binding 1.862E-2 3.665E-2
1.499E-1
6.144E-1
 1 70
17 GO:0038024 cargo receptor activity 1.888E-2 3.665E-2
1.499E-1
6.231E-1
 1 71
18 GO:0005254 chloride channel activity 2.152E-2 3.829E-2
1.565E-1
7.101E-1
 1 81
19 GO:0015297 antiporter activity 2.204E-2 3.829E-2
1.565E-1
7.275E-1
 1 83
20 GO:0015108 chloride transmembrane transporter activity 2.441E-2 3.877E-2
1.585E-1
8.056E-1
 1 92
21 GO:0005253 anion channel activity 2.467E-2 3.877E-2
1.585E-1
8.142E-1
 1 93
Show 16 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 135 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007605 sensory perception of sound 6.499E-6 6.734E-4 3.694E-3 8.773E-4 3 163
2 GO:0050954 sensory perception of mechanical stimulus 9.976E-6 6.734E-4 3.694E-3 1.347E-3 3 188
3 GO:0009751 response to salicylic acid 2.685E-4 1.208E-2
6.628E-2
 3.625E-2 1 1
4 GO:2000360 negative regulation of binding of sperm to zona pellucida 1.074E-3 2.071E-2
1.136E-1
1.449E-1
 1 4
5 GO:0043152 induction of bacterial agglutination 1.074E-3 2.071E-2
1.136E-1
1.449E-1
 1 4
6 GO:0060478 acrosomal vesicle exocytosis 1.074E-3 2.071E-2
1.136E-1
1.449E-1
 1 4
7 GO:0015755 fructose transmembrane transport 1.074E-3 2.071E-2
1.136E-1
1.449E-1
 1 4
8 GO:2000359 regulation of binding of sperm to zona pellucida 1.342E-3 2.091E-2
1.147E-1
1.811E-1
 1 5
9 GO:0006959 humoral immune response 1.394E-3 2.091E-2
1.147E-1
1.882E-1
 2 223
10 GO:0060467 negative regulation of fertilization 1.878E-3 2.536E-2
1.391E-1
2.536E-1
 1 7
11 GO:2000344 positive regulation of acrosome reaction 2.414E-3 2.963E-2
1.626E-1
3.259E-1
 1 9
12 GO:0019532 oxalate transport 3.218E-3 3.417E-2
1.875E-1
4.344E-1
 1 12
13 GO:1902358 sulfate transmembrane transport 3.486E-3 3.417E-2
1.875E-1
4.706E-1
 1 13
14 GO:0001833 inner cell mass cell proliferation 3.754E-3 3.417E-2
1.875E-1
5.067E-1
 1 14
15 GO:0008272 sulfate transport 4.021E-3 3.417E-2
1.875E-1
5.429E-1
 1 15
16 GO:0035864 response to potassium ion 4.289E-3 3.417E-2
1.875E-1
5.790E-1
 1 16
17 GO:0045793 positive regulation of cell size 4.556E-3 3.417E-2
1.875E-1
6.151E-1
 1 17
18 GO:1902074 response to salt 4.556E-3 3.417E-2
1.875E-1
6.151E-1
 1 17
19 GO:0060046 regulation of acrosome reaction 4.824E-3 3.428E-2
1.880E-1
6.512E-1
 1 18
20 GO:0002922 positive regulation of humoral immune response 5.091E-3 3.437E-2
1.885E-1
6.873E-1
 1 19
21 GO:0010996 response to auditory stimulus 6.161E-3 3.780E-2
2.074E-1
8.317E-1
 1 23
22 GO:0097066 response to thyroid hormone 6.161E-3 3.780E-2
2.074E-1
8.317E-1
 1 23
23 GO:0001832 blastocyst growth 6.962E-3 4.048E-2
2.221E-1
9.399E-1
 1 26
24 GO:0010737 protein kinase A signaling 7.229E-3 4.048E-2
2.221E-1
9.759E-1
 1 27
25 GO:0045956 positive regulation of calcium ion-dependent exocytosis 7.496E-3 4.048E-2
2.221E-1
1.000E0
 1 28
26 GO:0070528 protein kinase C signaling 8.830E-3 4.359E-2
2.391E-1
1.000E0
 1 33
27 GO:0007340 acrosome reaction 8.830E-3 4.359E-2
2.391E-1
1.000E0
 1 33
28 GO:0002931 response to ischemia 9.096E-3 4.359E-2
2.391E-1
1.000E0
 1 34
29 GO:0072348 sulfur compound transport 9.363E-3 4.359E-2
2.391E-1
1.000E0
 1 35
30 GO:0007339 binding of sperm to zona pellucida 9.896E-3 4.453E-2
2.443E-1
1.000E0
 1 37
Show 25 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 13 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031012 extracellular matrix 1.426E-6 1.854E-5 5.895E-5 1.854E-5 4 444
2 GO:0031225 anchored component of membrane 6.887E-4 4.477E-3 1.424E-2 8.953E-3 2 160
3 GO:0042589 zymogen granule membrane 3.667E-3 1.589E-2
5.054E-2
 4.768E-2 1 14
4 GO:0042588 zymogen granule 6.280E-3 2.041E-2
6.491E-2
8.165E-2
 1 24
5 GO:0016328 lateral plasma membrane 1.383E-2 3.389E-2
1.078E-1
1.798E-1
 1 53
6 GO:0030670 phagocytic vesicle membrane 1.564E-2 3.389E-2
1.078E-1
2.033E-1
 1 60
7 GO:0045335 phagocytic vesicle 2.287E-2 3.759E-2
1.195E-1
2.974E-1
 1 88
8 GO:0030667 secretory granule membrane 2.313E-2 3.759E-2
1.195E-1
3.007E-1
 1 89
Show 3 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 0 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 4 input genes in category / 111 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004415 abnormal cochlear nerve compound action potential 4.370E-8 4.850E-6 2.566E-5 4.850E-6 3 24
2 MP:0014089 abnormal tectorial membrane marginal band morphology 1.119E-7 6.212E-6 3.287E-5 1.242E-5 2 2
3 MP:0013962 absent Hensen stripe 6.714E-7 2.179E-5 1.153E-4 7.452E-5 2 4
4 MP:0013961 abnormal Hensen stripe morphology 1.119E-6 2.179E-5 1.153E-4 1.242E-4 2 5
5 MP:0004736 abnormal distortion product otoacoustic emission 1.127E-6 2.179E-5 1.153E-4 1.251E-4 3 69
6 MP:0006336 abnormal otoacoustic response 1.178E-6 2.179E-5 1.153E-4 1.307E-4 3 70
7 MP:0014091 abnormal tectorial membrane striated-sheet matrix morphology 3.131E-6 4.966E-5 2.627E-4 3.476E-4 2 8
8 MP:0004417 decreased cochlear nerve compound action potential 6.149E-6 8.531E-5 4.514E-4 6.825E-4 2 11
9 MP:0005402 abnormal action potential 9.175E-6 1.132E-4 5.987E-4 1.018E-3 3 138
10 MP:0004412 abnormal cochlear microphonics 1.709E-5 1.897E-4 1.004E-3 1.897E-3 2 18
11 MP:0006332 abnormal cochlear potential 1.910E-5 1.927E-4 1.020E-3 2.120E-3 2 19
12 MP:0006325 impaired hearing 3.194E-5 2.955E-4 1.563E-3 3.546E-3 3 209
13 MP:0003169 abnormal scala media morphology 4.368E-5 3.351E-4 1.773E-3 4.849E-3 3 232
14 MP:0004426 abnormal cochlear labyrinth morphology 4.368E-5 3.351E-4 1.773E-3 4.849E-3 3 232
15 MP:0004434 abnormal cochlear outer hair cell physiology 4.528E-5 3.351E-4 1.773E-3 5.026E-3 2 29
16 MP:0000031 abnormal cochlea morphology 5.143E-5 3.568E-4 1.888E-3 5.709E-3 3 245
17 MP:0003149 abnormal tectorial membrane morphology 6.253E-5 3.874E-4 2.050E-3 6.941E-3 2 34
18 MP:0000035 abnormal membranous labyrinth morphology 6.505E-5 3.874E-4 2.050E-3 7.220E-3 3 265
19 MP:0004737 absent distortion product otoacoustic emissions 6.631E-5 3.874E-4 2.050E-3 7.361E-3 2 35
20 MP:0004432 abnormal cochlear hair cell physiology 7.832E-5 4.347E-4 2.300E-3 8.693E-3 2 38
21 MP:0000026 abnormal inner ear morphology 9.520E-5 5.032E-4 2.662E-3 1.057E-2 3 301
22 MP:0003879 abnormal hair cell physiology 1.152E-4 5.812E-4 3.075E-3 1.279E-2 2 46
23 MP:0002272 abnormal nervous system electrophysiology 1.611E-4 7.774E-4 4.113E-3 1.788E-2 3 359
24 MP:0006335 abnormal hearing electrophysiology 2.109E-4 9.756E-4 5.162E-3 2.341E-2 3 393
25 MP:0010055 abnormal sensory neuron physiology 2.528E-4 1.122E-3 5.939E-3 2.806E-2 2 68
26 MP:0001963 abnormal hearing physiology 3.326E-4 1.383E-3 7.319E-3 3.692E-2 3 458
27 MP:0005423 abnormal somatic nervous system physiology 3.679E-4 1.383E-3 7.319E-3 4.083E-2 2 82
28 MP:0004436 absent cochlear outer hair cell electromotility 3.863E-4 1.383E-3 7.319E-3 4.288E-2 1 1
29 MP:0014090 abnormal tectorial membrane covernet morphology 3.863E-4 1.383E-3 7.319E-3 4.288E-2 1 1
30 MP:0014088 abnormal Kimura membrane morphology 3.863E-4 1.383E-3 7.319E-3 4.288E-2 1 1
31 MP:0006384 enhanced cochlear frequency tuning 3.863E-4 1.383E-3 7.319E-3 4.288E-2 1 1
32 MP:0002102 abnormal ear morphology 4.139E-4 1.436E-3 7.597E-3 4.595E-2 3 493
33 MP:0006383 abnormal cochlear frequency tuning 7.725E-4 2.598E-3 1.375E-2
8.574E-2
 1 2
34 MP:0004437 decreased cochlear outer hair cell electromotility 1.159E-3 3.572E-3 1.890E-2
1.286E-1
 1 3
35 MP:0004767 increased cochlear nerve compound action potential 1.159E-3 3.572E-3 1.890E-2
1.286E-1
 1 3
36 MP:0004435 abnormal cochlear outer hair cell electromotility 1.159E-3 3.572E-3 1.890E-2
1.286E-1
 1 3
37 MP:0004430 abnormal Claudius cell morphology 1.544E-3 4.633E-3 2.452E-2
1.714E-1
 1 4
38 MP:0004414 decreased cochlear microphonics 1.930E-3 5.639E-3 2.983E-2
2.143E-1
 1 5
39 MP:0002622 abnormal cochlear hair cell morphology 2.107E-3 5.997E-3 3.173E-2
2.339E-1
 2 197
40 MP:0003308 abnormal cochlear sensory epithelium morphology 2.236E-3 6.025E-3 3.188E-2
2.482E-1
 2 203
41 MP:0000042 abnormal organ of Corti morphology 2.280E-3 6.025E-3 3.188E-2
2.530E-1
 2 205
42 MP:0000045 abnormal hair cell morphology 2.280E-3 6.025E-3 3.188E-2
2.530E-1
 2 205
43 MP:0003150 detached tectorial membrane 2.702E-3 6.974E-3 3.690E-2
2.999E-1
 1 7
44 MP:0000972 abnormal mechanoreceptor morphology 2.837E-3 7.157E-3 3.787E-2
3.149E-1
 2 229
45 MP:0004591 enlarged tectorial membrane 3.473E-3 8.379E-3 4.434E-2
3.855E-1
 1 9
46 MP:0003144 decreased otolith number 3.473E-3 8.379E-3 4.434E-2
3.855E-1
 1 9
47 MP:0004413 absent cochlear microphonics 4.243E-3 9.612E-3
5.086E-2
4.710E-1
 1 11
48 MP:0003143 enlarged otoliths 4.243E-3 9.612E-3
5.086E-2
4.710E-1
 1 11
49 MP:0000525 renal tubular acidosis 4.243E-3 9.612E-3
5.086E-2
4.710E-1
 1 11
50 MP:0003017 decreased circulating bicarbonate level 4.628E-3 1.027E-2
5.436E-2
5.137E-1
 1 12
Show 45 more annotations

6: Domain [Display Chart] 5 input genes in category / 58 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR017977 ZP dom CS InterPro 2.046E-13 1.186E-11 5.512E-11 1.186E-11 4 10
2 PS51034 ZP 2 PROSITE 9.749E-13 1.885E-11 8.757E-11 5.654E-11 4 14
3 PS00682 ZP 1 PROSITE 9.749E-13 1.885E-11 8.757E-11 5.654E-11 4 14
4 SM00241 ZP SMART 1.329E-12 1.928E-11 8.956E-11 7.710E-11 4 15
5 IPR001507 ZP dom InterPro 2.318E-12 2.240E-11 1.041E-10 1.344E-10 4 17
6 PF00100 Zona pellucida Pfam 2.318E-12 2.240E-11 1.041E-10 1.344E-10 4 17
7 IPR033026 TECTA InterPro 2.669E-4 1.935E-3 8.990E-3 1.548E-2 1 1
8 IPR030282 Prestin InterPro 2.669E-4 1.935E-3 8.990E-3 1.548E-2 1 1
9 PF12714 TILa Pfam 8.005E-4 4.643E-3 2.157E-2 4.643E-2 1 3
10 IPR025615 TILa dom InterPro 8.005E-4 4.643E-3 2.157E-2 4.643E-2 1 3
11 PS51220 NIDO PROSITE 1.334E-3 5.526E-3 2.567E-2
7.736E-2
 1 5
12 IPR003886 NIDO dom InterPro 1.334E-3 5.526E-3 2.567E-2
7.736E-2
 1 5
13 PF06119 NIDO Pfam 1.334E-3 5.526E-3 2.567E-2
7.736E-2
 1 5
14 SM00539 NIDO SMART 1.334E-3 5.526E-3 2.567E-2
7.736E-2
 1 5
15 IPR018045 S04 transporter CS InterPro 1.867E-3 5.798E-3 2.694E-2
1.083E-1
 1 7
16 IPR017957 P trefoil CS InterPro 2.133E-3 5.798E-3 2.694E-2
1.237E-1
 1 8
17 PF00088 Trefoil Pfam 2.133E-3 5.798E-3 2.694E-2
1.237E-1
 1 8
18 PS00025 P TREFOIL 1 PROSITE 2.133E-3 5.798E-3 2.694E-2
1.237E-1
 1 8
19 PS51448 P TREFOIL 2 PROSITE 2.400E-3 5.798E-3 2.694E-2
1.392E-1
 1 9
20 SM00018 PD SMART 2.400E-3 5.798E-3 2.694E-2
1.392E-1
 1 9
21 PS01130 SLC26A PROSITE 2.666E-3 5.798E-3 2.694E-2
1.546E-1
 1 10
22 4.10.110.10 - Gene3D 2.933E-3 5.798E-3 2.694E-2
1.701E-1
 1 11
23 PS50801 STAS PROSITE 2.933E-3 5.798E-3 2.694E-2
1.701E-1
 1 11
24 IPR001902 SLC26A/SulP fam InterPro 2.933E-3 5.798E-3 2.694E-2
1.701E-1
 1 11
25 PF00916 Sulfate transp Pfam 2.933E-3 5.798E-3 2.694E-2
1.701E-1
 1 11
26 IPR011547 SLC26A/SulP dom InterPro 2.933E-3 5.798E-3 2.694E-2
1.701E-1
 1 11
27 IPR002645 STAS dom InterPro 2.933E-3 5.798E-3 2.694E-2
1.701E-1
 1 11
28 3.30.750.24 - Gene3D 2.933E-3 5.798E-3 2.694E-2
1.701E-1
 1 11
29 PF01740 STAS Pfam 2.933E-3 5.798E-3 2.694E-2
1.701E-1
 1 11
30 IPR000519 P trefoil dom InterPro 3.199E-3 5.798E-3 2.694E-2
1.855E-1
 1 12
31 PF01826 TIL Pfam 3.199E-3 5.798E-3 2.694E-2
1.855E-1
 1 12
32 PF08742 C8 Pfam 3.199E-3 5.798E-3 2.694E-2
1.855E-1
 1 12
33 SM00832 C8 SMART 3.465E-3 5.911E-3 2.746E-2
2.010E-1
 1 13
34 IPR014853 Unchr dom Cys-rich InterPro 3.465E-3 5.911E-3 2.746E-2
2.010E-1
 1 13
35 IPR002919 TIL dom InterPro 3.731E-3 6.183E-3 2.873E-2
2.164E-1
 1 14
36 SM00216 VWD SMART 4.263E-3 6.340E-3 2.946E-2
2.473E-1
 1 16
37 PS51233 VWFD PROSITE 4.263E-3 6.340E-3 2.946E-2
2.473E-1
 1 16
38 IPR001846 VWF type-D InterPro 4.263E-3 6.340E-3 2.946E-2
2.473E-1
 1 16
39 PF00094 VWD Pfam 4.263E-3 6.340E-3 2.946E-2
2.473E-1
 1 16
40 SM00215 VWC out SMART 5.061E-3 7.338E-3 3.410E-2
2.935E-1
 1 19
41 PF00530 SRCR Pfam 5.593E-3 7.911E-3 3.676E-2
3.244E-1
 1 21
42 SM00202 SR SMART 6.655E-3 8.726E-3 4.054E-2
3.860E-1
 1 25
43 3.10.250.10 - Gene3D 6.655E-3 8.726E-3 4.054E-2
3.860E-1
 1 25
44 PS50287 SRCR 2 PROSITE 6.920E-3 8.726E-3 4.054E-2
4.014E-1
 1 26
45 PS00420 SRCR 1 PROSITE 6.920E-3 8.726E-3 4.054E-2
4.014E-1
 1 26
46 IPR017448 SRCR-like dom InterPro 6.920E-3 8.726E-3 4.054E-2
4.014E-1
 1 26
47 IPR001190 SRCR InterPro 7.186E-3 8.868E-3 4.120E-2
4.168E-1
 1 27
48 PS50184 VWFC 2 PROSITE 1.010E-2 1.196E-2
5.555E-2
5.859E-1
 1 38
49 SM00214 VWC SMART 1.010E-2 1.196E-2
5.555E-2
5.859E-1
 1 38
50 IPR001007 VWF dom InterPro 1.116E-2 1.295E-2
6.015E-2
6.473E-1
 1 42
Show 45 more annotations

7: Pathway [Display Chart] 4 input genes in category / 8 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3008 Genes encoding structural ECM glycoproteins MSigDB C2 BIOCARTA (v6.0) 5.959E-8 4.767E-7 1.296E-6 4.767E-7 4 196
2 M5884 Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans MSigDB C2 BIOCARTA (v6.0) 2.330E-7 9.320E-7 2.533E-6 1.864E-6 4 275
3 1268710 Post-translational modification: synthesis of GPI-anchored proteins BioSystems: REACTOME 3.210E-4 8.560E-4 2.326E-3 2.568E-3 2 92
4 1269337 Interaction With The Zona Pellucida BioSystems: REACTOME 3.209E-3 6.419E-3 1.745E-2 2.567E-2 1 10
5 1269334 Fertilization BioSystems: REACTOME 8.328E-3 1.098E-2 2.983E-2
6.663E-2
 1 26
6 1269333 Reproduction BioSystems: REACTOME 8.328E-3 1.098E-2 2.983E-2
6.663E-2
 1 26
7 1309223 Surfactant metabolism BioSystems: REACTOME 9.605E-3 1.098E-2 2.983E-2
7.684E-2
 1 30
8 153376 Salivary secretion BioSystems: KEGG 2.861E-2 2.861E-2
7.775E-2
2.289E-1
 1 90
Show 3 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 323 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9079715 The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system. Pubmed 1.371E-8 7.381E-7 4.692E-6 4.429E-6 2 2
2 17220887 Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane. Pubmed 1.371E-8 7.381E-7 4.692E-6 4.429E-6 2 2
3 20142329 Deficient forward transduction and enhanced reverse transduction in the alpha tectorin C1509G human hearing loss mutation. Pubmed 1.371E-8 7.381E-7 4.692E-6 4.429E-6 2 2
4 24376553 Prestin regulation and function in residual outer hair cells after noise-induced hearing loss. Pubmed 1.371E-8 7.381E-7 4.692E-6 4.429E-6 2 2
5 11933161 A novel seminal plasma glycoprotein of a teleost, the Nile tilapia (Oreochromis niloticus), contains a partial von Willebrand factor type D domain and a zona pellucida-like domain. Pubmed 1.371E-8 7.381E-7 4.692E-6 4.429E-6 2 2
6 10023815 Tectorin mRNA expression is spatially and temporally restricted during mouse inner ear development. Pubmed 1.371E-8 7.381E-7 4.692E-6 4.429E-6 2 2
7 22544735 Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies. Pubmed 4.113E-8 1.476E-6 9.383E-6 1.329E-5 2 3
8 11972037 Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. Pubmed 4.113E-8 1.476E-6 9.383E-6 1.329E-5 2 3
9 26806019 Tectorins crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus. Pubmed 4.113E-8 1.476E-6 9.383E-6 1.329E-5 2 3
10 28935705 A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane. Pubmed 8.226E-8 2.657E-6 1.689E-5 2.657E-5 2 4
11 20803598 Expression, functional, and structural analysis of proteins critical for otoconia development. Pubmed 2.879E-7 8.453E-6 5.373E-5 9.298E-5 2 7
12 16141228 The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Pubmed 3.838E-7 1.033E-5 6.566E-5 1.240E-4 2 8
13 20856818 Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1. Pubmed 1.644E-6 4.085E-5 2.597E-4 5.311E-4 2 16
14 22808246 Developmental gene expression profiling along the tonotopic axis of the mouse cochlea. Pubmed 4.806E-6 1.109E-4 7.049E-4 1.552E-3 2 27
15 20301607 Deafness and Hereditary Hearing Loss Overview Pubmed 3.113E-5 2.073E-4 1.318E-3 1.005E-2 2 68
16 11550206 Prostatic expression of hensin, a protein implicated in epithelial terminal differentiation. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
17 9590290 Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
18 15760920 Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
19 18020944 Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
20 16796526 The N-terminal SRCR-SID domain of gp-340 interacts with HIV type 1 gp120 sequences and inhibits viral infection. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
21 15866713 Generation of a vector system facilitating cloning of DMBT1 variants and recombinant expression of functional full-length DMBT1. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
22 16190864 Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
23 9949200 An alpha-tectorin gene defect causes a newly identified autosomal recessive form of sensorineural pre-lingual non-syndromic deafness, DFNB21. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
24 18575463 Mid-frequency DFNA8/12 hearing loss caused by a synonymous TECTA mutation that affects an exonic splice enhancer. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
25 19515900 Structural rearrangements of the motor protein prestin revealed by fluorescence resonance energy transfer. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
26 12719379 Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
27 9888459 Lack of DMBT1 expression in oesophageal, gastric and colon cancers. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
28 12203780 Sequential changes of the DMBT1 expression and location in normal lung tissue and lung carcinomas. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
29 18567583 Membrane composition modulates prestin-associated charge movement. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
30 25413827 Novel TECTA mutations identified in stable sensorineural hearing loss and their clinical implications. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
31 18516034 Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
32 21520338 DFNA8/12 caused by TECTA mutations is the most identified subtype of nonsyndromic autosomal dominant hearing loss. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
33 15319415 Cochlear function in Prestin knockout mice. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
34 23212912 The V499G/Y501H mutation impairs fast motor kinetics of prestin and has significance for defining functional independence of individual prestin subunits. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
35 17415610 Developmental expression of the outer hair cell motor prestin in the mouse. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
36 18452040 Characterization of a spontaneous, recessive, missense mutation arising in the Tecta gene. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
37 17151276 Essential helix interactions in the anion transporter domain of prestin revealed by evolutionary trace analysis. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
38 14523068 Role of the tectorial membrane revealed by otoacoustic emissions recorded from wild-type and transgenic Tecta(deltaENT/deltaENT) mice. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
39 21173071 Human ZP4 is not sufficient for taxon-specific sperm recognition of the zona pellucida in transgenic mice. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
40 14747354 Tension sensitivity of prestin: comparison with the membrane motor in outer hair cells. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
41 14732920 Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
42 20418254 Review: Gp-340/DMBT1 in mucosal innate immunity. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
43 23506885 The SLC26 gene family of anion transporters and channels. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
44 27232762 Abnormal mRNA splicing but normal auditory brainstem response (ABR) in mice with the prestin (SLC26A5) IVS2-2A>G mutation. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
45 9718342 Evidence for digenic inheritance of nonsyndromic hereditary hearing loss in a Swedish family. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
46 21959151 Prestin links extrinsic tuning to neural excitation in the mammalian cochlea. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
47 23029017 Normal hearing sensitivity at low-to-middle frequencies with 34% prestin-charge density. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
48 15242536 gp340 (SAG) binds to the V3 sequence of gp120 important for chemokine receptor interaction. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
49 28364129 The scavenging capacity of DMBT1 is impaired by germline deletions. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
50 12871854 Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses. Pubmed 1.309E-4 2.073E-4 1.318E-3 4.229E-2 1 1
Show 45 more annotations

9: Interaction [Display Chart] 3 input genes in category / 18 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ZP4 ZP4 interactions 3.389E-4 3.050E-3 1.066E-2 6.100E-3 1 2
2 int:TECTA TECTA interactions 3.389E-4 3.050E-3 1.066E-2 6.100E-3 1 2
3 int:SFTPD SFTPD interactions 1.186E-3 6.098E-3 2.131E-2 2.135E-2 1 7
4 int:SFTPA1 SFTPA1 interactions 1.355E-3 6.098E-3 2.131E-2 2.439E-2 1 8
5 int:ARHGAP12 ARHGAP12 interactions 2.032E-3 7.316E-3 2.557E-2 3.658E-2 1 12
6 int:DMBT1 DMBT1 interactions 2.709E-3 8.127E-3 2.841E-2 4.876E-2 1 16
7 int:HBM HBM interactions 3.555E-3 9.141E-3 3.195E-2
6.398E-2
 1 21
8 int:HTN3 HTN3 interactions 4.738E-3 1.066E-2 3.726E-2
8.528E-2
 1 28
9 int:FURIN FURIN interactions 6.257E-3 1.079E-2 3.772E-2
1.126E-1
 1 37
10 int:ICE2 ICE2 interactions 6.426E-3 1.079E-2 3.772E-2
1.157E-1
 1 38
11 int:PCK2 PCK2 interactions 6.595E-3 1.079E-2 3.772E-2
1.187E-1
 1 39
12 int:FRMD1 FRMD1 interactions 7.944E-3 1.147E-2 4.008E-2
1.430E-1
 1 47
13 int:EID1 EID1 interactions 8.281E-3 1.147E-2 4.008E-2
1.491E-1
 1 49
14 int:SNX27 SNX27 interactions 1.350E-2 1.735E-2
6.065E-2
2.429E-1
 1 80
15 int:PARD6B PARD6B interactions 1.450E-2 1.740E-2
6.083E-2
2.611E-1
 1 86
16 int:DDX31 DDX31 interactions 1.769E-2 1.990E-2
6.955E-2
3.184E-1
 1 105
17 int:CDK6 CDK6 interactions 2.737E-2 2.898E-2
1.013E-1
4.927E-1
 1 163
Show 12 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11q22-q24 11q22-q24 1.443E-4 7.213E-4 1.647E-3 7.213E-4 1 1
2 10q25-q26 10q25-q26 5.769E-4 1.442E-3 3.293E-3 2.885E-3 1 4
3 10q26.13 10q26.13 5.901E-3 9.349E-3 2.135E-2 2.950E-2 1 41
4 1q43 1q43 7.479E-3 9.349E-3 2.135E-2 3.740E-2 1 52
5 7q22.1 7q22.1 1.662E-2 1.662E-2 3.796E-2
8.311E-2
 1 116

11: Transcription Factor Binding Site [Display Chart] 3 input genes in category / 21 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 3 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1152 Deafness associated genes genenames.org 1.755E-4 5.264E-4 9.651E-4 5.264E-4 2 140
2 8 Zona pellucida glycoproteins genenames.org 6.594E-4 9.892E-4 1.813E-3 1.978E-3 1 4

13: Coexpression [Display Chart] 5 input genes in category / 140 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M8222 Genes up-regulated in Pmel-1 CD8 T cells: naïve versus primed with cognate antigen (gp100) and IL2 [GeneID=3558]. MSigDB C7: Immunologic Signatures (v6.0) 6.282E-6 8.795E-4 4.857E-3 8.795E-4 3 200
2 20686847-Table3 Human Stomach Li10 19genes GeneSigDB 3.453E-3 4.859E-2
2.684E-1
4.834E-1
 1 16
3 M1482 Genes down-regulated in pancreatic cells from mice with double knockout of E2F1 [GeneID=1869] and E2F2 [GeneID=1870] compared to wild type. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.453E-3 4.859E-2
2.684E-1
4.834E-1
 1 16
4 15832406-Table5 Human Stomach Yu04 21genes GeneSigDB 4.100E-3 4.859E-2
2.684E-1
5.739E-1
 1 19
5 19190164-Table1 Human Bladder Rosser09 24genes GeneSigDB 5.176E-3 4.859E-2
2.684E-1
7.247E-1
 1 24
6 20459814-Table1 Rat Colon Femia10 50genes GeneSigDB 7.112E-3 4.859E-2
2.684E-1
9.956E-1
 1 33
7 M19164 Cluster d: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.971E-3 4.859E-2
2.684E-1
1.000E0
 1 37
8 M1516 Genes discriminating between direct (cisplatin, MMS, mitomycin C [PubChem=2767;4156;5746]) and indirect (paclitaxel, hydroxyurea, etoposide [PubChem=4666;3657;36462]) acting genotoxins at 4 h time point. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.971E-3 4.859E-2
2.684E-1
1.000E0
 1 37
9 15120960-Table4 Mouse Lymphoma Hu04 43genes GeneSigDB 8.400E-3 4.859E-2
2.684E-1
1.000E0
 1 39
10 20194811-Figure1c Human Lung not cancer Lockstone10 51genes GeneSigDB 9.044E-3 4.859E-2
2.684E-1
1.000E0
 1 42
11 M1887 Genes up-regulated in gastric mucosal tissue of mice on 2% cholesterol [PubChem=5997] diet and infected with H. pylori vs those infected with H. pylori while on 0% cholesterol diet. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.247E-2 4.859E-2
2.684E-1
1.000E0
 1 58
12 18310659-TableS2 Human Viral Maruyama08 64genes GeneSigDB 1.333E-2 4.859E-2
2.684E-1
1.000E0
 1 62
13 M2002 Genes with high-CpG-density promoters (HCP) without H3 methylation marks at K4 and K27 in embryonic stem cells (ES). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.354E-2 4.859E-2
2.684E-1
1.000E0
 1 63
14 M18496 Genes down-regulated in hepatocellular carcinoma (HCC) induced by overexpression of MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.354E-2 4.859E-2
2.684E-1
1.000E0
 1 63
15 M11640 Genes down-regulated in hepatocellular carcinoma (HCC) induced by ciprofibrate [PubChem=2763]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.418E-2 4.859E-2
2.684E-1
1.000E0
 1 66
16 M1424 Genes down-regulated in hepatocellular carcinoma (HCC) induced by diethylnitrosamine (DENA) [PubChem=5921]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.589E-2 4.859E-2
2.684E-1
1.000E0
 1 74
17 M1600 Genes up-regulated in the nucleus accumbens (a major reward center in the brain) after 4 weeks of cocaine [PubChem=5760] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.610E-2 4.859E-2
2.684E-1
1.000E0
 1 75
18 M1968 Genes with high-CpG-density promoters (HCP) without H3 methylation marks at either H3K4 or H3K27 in MCV8.1 cells (induced pluripotent cells, iPS). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.717E-2 4.859E-2
2.684E-1
1.000E0
 1 80
19 16357169-SuppTable2 Human Prostate Floryk05 95genes GeneSigDB 1.717E-2 4.859E-2
2.684E-1
1.000E0
 1 80
20 M11028 Genes in the most frequently gained loci in a panel of glioma cell lines. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.143E-2 4.859E-2
2.684E-1
1.000E0
 1 100
21 M2806 Genes up-regulated in astrocytes. MSigDB C6: Oncogenic Signatures (v6.0) 2.143E-2 4.859E-2
2.684E-1
1.000E0
 1 100
22 M2913 Genes up-regulated in skin from: wildtype (BALB/c) versus IFNG [GeneID=3458] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.567E-2 4.859E-2
2.684E-1
1.000E0
 1 120
23 M6916 Genes down-regulated in B lymphocytes: control versus anti IgM. MSigDB C7: Immunologic Signatures (v6.0) 2.630E-2 4.859E-2
2.684E-1
1.000E0
 1 123
24 M2792 Genes down-regulated in retina cells from CRX [Gene ID=1406] knockout mice. MSigDB C6: Oncogenic Signatures (v6.0) 2.863E-2 4.859E-2
2.684E-1
1.000E0
 1 134
25 M929 Genes up-regulated in colorectal adenoma compared to normal mucosa samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.968E-2 4.859E-2
2.684E-1
1.000E0
 1 139
26 12747878-Table3 Human Breast Huang03 164genes recurrence GeneSigDB 2.968E-2 4.859E-2
2.684E-1
1.000E0
 1 139
27 M2888 Genes up-regulated in epithelial breast cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 3.010E-2 4.859E-2
2.684E-1
1.000E0
 1 141
28 M9427 Genes down-regulated in wildtype DN3 thymocytes versus T cell lymphoma cells from TCF7 [GeneID=6932] knockout. MSigDB C7: Immunologic Signatures (v6.0) 3.053E-2 4.859E-2
2.684E-1
1.000E0
 1 143
29 M2900 Genes up-regulated in epithelial lung and breast cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 3.053E-2 4.859E-2
2.684E-1
1.000E0
 1 143
30 M2875 Genes up-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 3.053E-2 4.859E-2
2.684E-1
1.000E0
 1 143
31 M338 Genes down-regulated in Sez-2 cells (T cell lymphoma): IL15 [GeneID=3600] versus IL21 [GeneID=3600]. MSigDB C7: Immunologic Signatures (v6.0) 3.347E-2 4.859E-2
2.684E-1
1.000E0
 1 157
32 M8820 Genes down-regulated in T reg (FOXP3+ [GeneID=50943]) cells from NOD mice: Foxp3-Fusion-GFP versus Foxp3-ires-GFP. MSigDB C7: Immunologic Signatures (v6.0) 3.537E-2 4.859E-2
2.684E-1
1.000E0
 1 166
33 M2776 Cluster 1: genes up-regulated in lung tissue samples from mice with oncogenic form of KRAS [GeneID=3845] and inactivated PTEN [GeneID=5728]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.851E-2 4.859E-2
2.684E-1
1.000E0
 1 181
34 M2711 Genes up-regulated in primary epithelial breast cancer cell culture over-expressing MYC [Gene ID=4609] gene. MSigDB C6: Oncogenic Signatures (v6.0) 3.893E-2 4.859E-2
2.684E-1
1.000E0
 1 183
35 M2714 Genes up-regulated in primary epithelial breast cancer cell culture over-expressing SRC [Gene ID=6714] gene. MSigDB C6: Oncogenic Signatures (v6.0) 3.893E-2 4.859E-2
2.684E-1
1.000E0
 1 183
36 M2681 Genes down-regulated in myometrial cells over-expressing a shortened splice form of ATF2 [Gene ID=1386] gene. MSigDB C6: Oncogenic Signatures (v6.0) 3.977E-2 4.859E-2
2.684E-1
1.000E0
 1 187
37 M2632 Genes up-regulated in mouse fibroblasts over-expressing E2F1 [Gene ID=1869] gene. MSigDB C6: Oncogenic Signatures (v6.0) 3.998E-2 4.859E-2
2.684E-1
1.000E0
 1 188
38 M7584 Genes up-regulated in CD11b EL4 Tumor from C57BL6 mouse versus CD11b MCA203 Tumor from C57BL6 mouse. MSigDB C7: Immunologic Signatures (v6.0) 4.019E-2 4.859E-2
2.684E-1
1.000E0
 1 189
39 M9727 Genes down-regulated in CD4 [GeneID=920] SMARTA T cells: naïve versus effector during acute infection of LCMV. MSigDB C7: Immunologic Signatures (v6.0) 4.039E-2 4.859E-2
2.684E-1
1.000E0
 1 190
40 M9732 Genes down-regulated in CD4 [GeneID=920] SMARTA T cells: naïve versus Ly6c+ CXCR5+ [GeneID=643] effector during acute infection of LCMV. MSigDB C7: Immunologic Signatures (v6.0) 4.039E-2 4.859E-2
2.684E-1
1.000E0
 1 190
41 M8011 Genes down-regulated in macrophages (12h): IFNG and TNF [GeneID=3458;7124] versus IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 4.060E-2 4.859E-2
2.684E-1
1.000E0
 1 191
42 M2736 Genes up-regulated in TIG3 cells (fibroblasts) upon knockdown of EED [Gene ID=8726] gene. MSigDB C6: Oncogenic Signatures (v6.0) 4.081E-2 4.859E-2
2.684E-1
1.000E0
 1 192
43 M4905 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus that after the vaccination MSigDB C7: Immunologic Signatures (v6.0) 4.102E-2 4.859E-2
2.684E-1
1.000E0
 1 193
44 M9977 Genes down-regulated during primary acute viral infection in ITGAM+ [GeneID=3684] dendritic cells: wildtype versus IFNAR1 [GeneID=3454] knockout. MSigDB C7: Immunologic Signatures (v6.0) 4.123E-2 4.859E-2
2.684E-1
1.000E0
 1 194
45 M4907 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those from day 3 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 4.144E-2 4.859E-2
2.684E-1
1.000E0
 1 195
46 M6167 Genes up-regulated in D10.G4.1 T cell line (3h): control versus treated with NMU [GeneID=10874]. MSigDB C7: Immunologic Signatures (v6.0) 4.144E-2 4.859E-2
2.684E-1
1.000E0
 1 195
47 M9973 Genes down-regulated in ITGAM+ [GeneID=3684] dendritic cells: wildtype versus IFNAR1 [GeneID=3454]. MSigDB C7: Immunologic Signatures (v6.0) 4.144E-2 4.859E-2
2.684E-1
1.000E0
 1 195
48 M6076 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (2h) versus TGFB1 [GeneID=7040] and IL-12 (2h). MSigDB C7: Immunologic Signatures (v6.0) 4.165E-2 4.859E-2
2.684E-1
1.000E0
 1 196
49 M8345 Genes down-regulated in activated versus induced T reg cells. MSigDB C7: Immunologic Signatures (v6.0) 4.165E-2 4.859E-2
2.684E-1
1.000E0
 1 196
50 M7395 Genes up-regulated in T reg cells: wildtype versus FOXO1 and FOXO3 [GeneID=2308;2309]. MSigDB C7: Immunologic Signatures (v6.0) 4.165E-2 4.859E-2
2.684E-1
1.000E0
 1 196
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 4 input genes in category / 83 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 1 input genes in category / 6 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M19241 MODULE 181 Genes in the cancer module 181. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.049E-2 4.324E-2
1.059E-1
1.829E-1
 1 306
2 M17233 MODULE 104 Genes in the cancer module 104. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.517E-2 4.324E-2
1.059E-1
2.110E-1
 1 353
3 M8921 MODULE 53 Cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.035E-2 4.324E-2
1.059E-1
2.421E-1
 1 405
4 M12108 MODULE 118 cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.085E-2 4.324E-2
1.059E-1
2.451E-1
 1 410
5 M15336 MODULE 6 Trachea genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.145E-2 4.324E-2
1.059E-1
2.487E-1
 1 416
6 M7383 MODULE 5 Lung genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.324E-2 4.324E-2
1.059E-1
2.594E-1
 1 434
Show 1 more annotation

16: MicroRNA [Display Chart] 5 input genes in category / 3 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-3186-5p:mirSVR highEffct hsa-miR-3186-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.246E-3 2.174E-2 3.986E-2 2.174E-2 1 105
2 hsa-miR-421:TargetScan hsa-miR-421 TargetScan 2.277E-2 2.745E-2
5.032E-2
6.831E-2
 1 332
3 hsa-miR-553:mirSVR highEffct hsa-miR-553:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.745E-2 2.745E-2
5.032E-2
8.235E-2
 1 401

17: Drug [Display Chart] 5 input genes in category / 566 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID005497094 Na-Z Stitch 1.778E-5 1.006E-2
6.961E-2
 1.006E-2 2 31
2 3989 UP Etofenamate [30544-47-9]; Up 200; 10.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.057E-4 4.493E-2
3.108E-1
3.994E-1
 2 194
3 7034 UP Dihydroergocristine mesylate [24730-10-7]; Up 200; 5.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.130E-4 4.493E-2
3.108E-1
4.035E-1
 2 195
4 6133 UP Verteporfin [129497-78-5]; Up 200; 2.8uM; HL60; HT HG-U133A Broad Institute CMAP Up 7.203E-4 4.493E-2
3.108E-1
4.077E-1
 2 196
5 4618 UP Methylhydantoin-5-(L) [40856-73-3]; Up 200; 35uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.276E-4 4.493E-2
3.108E-1
4.118E-1
 2 197
6 CID000003622 Nsc34399 Stitch 1.313E-3 4.493E-2
3.108E-1
7.431E-1
 1 6
7 CID000196672 a-5a Stitch 1.750E-3 4.493E-2
3.108E-1
9.906E-1
 1 8
8 CID000073973 sodium selenide Stitch 1.750E-3 4.493E-2
3.108E-1
9.906E-1
 1 8
9 CID000014827 litharge Stitch 2.406E-3 4.493E-2
3.108E-1
1.000E0
 1 11
10 CID000407919 AC1L8TMM Stitch 2.843E-3 4.493E-2
3.108E-1
1.000E0
 1 13
11 CID000447122 I-o-T Stitch 3.280E-3 4.493E-2
3.108E-1
1.000E0
 1 15
12 CID000123837 Nuclear Yellow Stitch 3.498E-3 4.493E-2
3.108E-1
1.000E0
 1 16
13 CID000006694 rhodamine Stitch 4.153E-3 4.493E-2
3.108E-1
1.000E0
 1 19
14 CID000003939 LiOH Stitch 4.153E-3 4.493E-2
3.108E-1
1.000E0
 1 19
15 CID000012835 5-methoxytryptophol Stitch 4.807E-3 4.493E-2
3.108E-1
1.000E0
 1 22
16 ctd:C009007 potassium persulfate CTD 4.807E-3 4.493E-2
3.108E-1
1.000E0
 1 22
17 CID003674064 mobs Stitch 4.807E-3 4.493E-2
3.108E-1
1.000E0
 1 22
18 CID000002432 PbTx-2 Stitch 5.679E-3 4.493E-2
3.108E-1
1.000E0
 1 26
19 CID000010685 tryptophol Stitch 5.897E-3 4.493E-2
3.108E-1
1.000E0
 1 27
20 CID000005849 pentolinium Stitch 6.115E-3 4.493E-2
3.108E-1
1.000E0
 1 28
21 CID000115111 WAY 100135 Stitch 6.333E-3 4.493E-2
3.108E-1
1.000E0
 1 29
22 CID000449430 II P Stitch 6.986E-3 4.493E-2
3.108E-1
1.000E0
 1 32
23 CID000010235 cytisine Stitch 7.204E-3 4.493E-2
3.108E-1
1.000E0
 1 33
24 CID000007107 xanthan Stitch 7.856E-3 4.493E-2
3.108E-1
1.000E0
 1 36
25 CID000085466 1m2r Stitch 7.856E-3 4.493E-2
3.108E-1
1.000E0
 1 36
26 CID006857719 AC1OAH4D Stitch 7.856E-3 4.493E-2
3.108E-1
1.000E0
 1 36
27 CID000260803 NSC92535 Stitch 8.726E-3 4.493E-2
3.108E-1
1.000E0
 1 40
28 ctd:C006593 2-anthramine CTD 8.944E-3 4.493E-2
3.108E-1
1.000E0
 1 41
29 CID000047627 NSC240899 Stitch 9.378E-3 4.493E-2
3.108E-1
1.000E0
 1 43
30 CID000012276 I pN Stitch 9.378E-3 4.493E-2
3.108E-1
1.000E0
 1 43
31 ctd:D012980 Sodium Salicylate CTD 9.813E-3 4.493E-2
3.108E-1
1.000E0
 1 45
32 CID000009216 dibenzo-p-dioxin Stitch 1.025E-2 4.493E-2
3.108E-1
1.000E0
 1 47
33 CID000065702 trofosfamide Stitch 1.046E-2 4.493E-2
3.108E-1
1.000E0
 1 48
34 CID000013850 hexadeca-10,12-dien-1-ol Stitch 1.068E-2 4.493E-2
3.108E-1
1.000E0
 1 49
35 CID000003150 AC1L1FA8 Stitch 1.090E-2 4.493E-2
3.108E-1
1.000E0
 1 50
36 CID000007409 1-phenylethanol Stitch 1.112E-2 4.493E-2
3.108E-1
1.000E0
 1 51
37 CID000008056 1,4-dibromobutane Stitch 1.155E-2 4.493E-2
3.108E-1
1.000E0
 1 53
38 CID000076313 1-naphthoxyacetic acid Stitch 1.155E-2 4.493E-2
3.108E-1
1.000E0
 1 53
39 CID003081562 Man5GlcNAc2 Stitch 1.198E-2 4.493E-2
3.108E-1
1.000E0
 1 55
40 CID006442259 Invader Stitch 1.220E-2 4.493E-2
3.108E-1
1.000E0
 1 56
41 CID000107640 NSC624746 Stitch 1.242E-2 4.493E-2
3.108E-1
1.000E0
 1 57
42 CID001536427 AC1LTNWX Stitch 1.263E-2 4.493E-2
3.108E-1
1.000E0
 1 58
43 CID000121907 EGTA-AM Stitch 1.350E-2 4.493E-2
3.108E-1
1.000E0
 1 62
44 CID005461123 silicon Stitch 1.393E-2 4.493E-2
3.108E-1
1.000E0
 1 64
45 CID000201538 benzilate Stitch 1.437E-2 4.493E-2
3.108E-1
1.000E0
 1 66
46 CID000062406 triflate Stitch 1.458E-2 4.493E-2
3.108E-1
1.000E0
 1 67
47 CID000002078 alachlor Stitch 1.545E-2 4.493E-2
3.108E-1
1.000E0
 1 71
48 CID000114810 monobromobimane Stitch 1.566E-2 4.493E-2
3.108E-1
1.000E0
 1 72
49 CID000003721 AC1L1GK8 Stitch 1.653E-2 4.493E-2
3.108E-1
1.000E0
 1 76
50 CID000005430 thiabendazole Stitch 1.653E-2 4.493E-2
3.108E-1
1.000E0
 1 76
Show 45 more annotations

18: Disease [Display Chart] 4 input genes in category / 59 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 OMIN:601543 DEAFNESS, AUTOSOMAL DOMINANT 12; DFNA12 OMIM 2.468E-4 2.080E-3 9.702E-3 1.456E-2 1 1
2 cv:C3151230 Deafness, autosomal recessive 61 Clinical Variations 2.468E-4 2.080E-3 9.702E-3 1.456E-2 1 1
3 OMIN:603629 DEAFNESS, AUTOSOMAL RECESSIVE 21; DFNB21 OMIM 2.468E-4 2.080E-3 9.702E-3 1.456E-2 1 1
4 C1863655 Deafness, Autosomal Recessive 21 DisGeNET Curated 2.468E-4 2.080E-3 9.702E-3 1.456E-2 1 1
5 C0496899 Benign neoplasm of brain, unspecified DisGeNET BeFree 2.468E-4 2.080E-3 9.702E-3 1.456E-2 1 1
6 cv:C1832187 Deafness, autosomal dominant 12 Clinical Variations 2.468E-4 2.080E-3 9.702E-3 1.456E-2 1 1
7 cv:C1863655 Deafness, autosomal recessive 21 Clinical Variations 2.468E-4 2.080E-3 9.702E-3 1.456E-2 1 1
8 C1832187 Deafness, Autosomal Dominant 12 DisGeNET Curated 4.936E-4 3.641E-3 1.698E-2 2.912E-2 1 2
9 C1866095 Deafness, Autosomal Dominant 13 DisGeNET Curated 7.404E-4 4.854E-3 2.263E-2 4.368E-2 1 3
10 C1879344 Biliary papillomatosis DisGeNET BeFree 1.234E-3 6.066E-3 2.829E-2
7.279E-2
 1 5
11 C0265274 Achondrogenesis, type IB (disorder) DisGeNET Curated 1.234E-3 6.066E-3 2.829E-2
7.279E-2
 1 5
12 C1848634 USHER SYNDROME, TYPE IIA DisGeNET Curated 1.234E-3 6.066E-3 2.829E-2
7.279E-2
 1 5
13 OMIN:155255 MEDULLOBLASTOMA; MDB OMIM 1.973E-3 8.956E-3 4.177E-2
1.164E-1
 1 8
14 OMIN:137800 GLIOMA SUSCEPTIBILITY 1; GLM1 OMIM 2.959E-3 1.247E-2
5.815E-2
1.746E-1
 1 12
15 C0265253 Stickler syndrome (disorder) DisGeNET BeFree 3.205E-3 1.261E-2
5.879E-2
1.891E-1
 1 13
16 C0018780 Hearing Loss, High-Frequency DisGeNET Curated 3.944E-3 1.454E-2
6.782E-2
2.327E-1
 1 16
17 C0026760 Multiple Epiphyseal Dysplasia DisGeNET Curated 4.928E-3 1.683E-2
7.848E-2
2.908E-1
 1 20
18 C0271829 Pendred's syndrome DisGeNET Curated 5.174E-3 1.683E-2
7.848E-2
3.053E-1
 1 21
19 C0574143 Liver calculus DisGeNET BeFree 5.420E-3 1.683E-2
7.848E-2
3.198E-1
 1 22
20 C0003615 Appendicitis DisGeNET Curated 5.911E-3 1.744E-2
8.132E-2
3.488E-1
 1 24
21 20081125:WTCCC Hypertension GWAS 6.649E-3 1.868E-2
8.711E-2
3.923E-1
 1 27
22 C2020284 Stickler syndrome, type 1 DisGeNET Curated 7.385E-3 1.981E-2
9.236E-2
4.357E-1
 1 30
23 C0034050 Pulmonary Alveolar Proteinosis DisGeNET Curated 7.876E-3 2.020E-2
9.422E-2
4.647E-1
 1 32
24 C1258085 Barrett Epithelium DisGeNET BeFree 8.612E-3 2.117E-2
9.873E-2
5.081E-1
 1 35
25 C0280785 Diffuse Astrocytoma DisGeNET BeFree 1.008E-2 2.344E-2
1.093E-1
5.949E-1
 1 41
26 C1843156 Hearing loss, progressive sensorineural DisGeNET Curated 1.033E-2 2.344E-2
1.093E-1
6.093E-1
 1 42
27 C0343284 Chondrodysplasia DisGeNET BeFree 1.082E-2 2.364E-2
1.102E-1
6.382E-1
 1 44
28 C0333519 Caries (morphologic abnormality) DisGeNET BeFree 1.326E-2 2.699E-2
1.258E-1
7.826E-1
 1 54
29 C0206716 Ganglioglioma DisGeNET BeFree 1.326E-2 2.699E-2
1.258E-1
7.826E-1
 1 54
30 C0023976 Long QT Syndrome DisGeNET Curated 1.668E-2 3.281E-2
1.530E-1
9.842E-1
 1 68
31 C3711374 Nonsyndromic Deafness DisGeNET BeFree 2.033E-2 3.870E-2
1.805E-1
1.000E0
 1 83
32 C0033036 Atrial Premature Complexes DisGeNET Curated 2.470E-2 4.554E-2
2.124E-1
1.000E0
 1 101
Show 27 more annotations