Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc383_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 52 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity 3.692E-10 1.920E-8 8.713E-8 1.920E-8 3 6
2 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1.550E-9 4.031E-8 1.829E-7 8.061E-8 3 9
3 GO:0035004 phosphatidylinositol 3-kinase activity 3.994E-9 6.922E-8 3.141E-7 2.077E-7 4 77
4 GO:0016303 1-phosphatidylinositol-3-kinase activity 2.268E-7 2.949E-6 1.338E-5 1.180E-5 3 43
5 GO:0052742 phosphatidylinositol kinase activity 5.661E-7 5.888E-6 2.672E-5 2.944E-5 3 58
6 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 6.935E-7 6.011E-6 2.728E-5 3.606E-5 3 62
7 GO:0052813 phosphatidylinositol bisphosphate kinase activity 1.092E-6 8.115E-6 3.682E-5 5.680E-5 3 72
8 GO:0019207 kinase regulator activity 2.981E-5 1.938E-4 8.794E-4 1.550E-3 3 216
9 GO:0004595 pantetheine-phosphate adenylyltransferase activity 3.215E-4 1.858E-3 8.430E-3 1.672E-2 1 1
10 GO:0097363 protein O-GlcNAc transferase activity 6.430E-4 3.039E-3 1.379E-2 3.343E-2 1 2
11 GO:0004140 dephospho-CoA kinase activity 6.430E-4 3.039E-3 1.379E-2 3.343E-2 1 2
12 GO:0016262 protein N-acetylglucosaminyltransferase activity 9.643E-4 4.179E-3 1.896E-2
5.014E-2
 1 3
13 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity 2.249E-3 8.995E-3 4.082E-2
1.169E-1
 1 7
14 GO:0043996 histone acetyltransferase activity (H4-K8 specific) 2.891E-3 9.395E-3 4.263E-2
1.503E-1
 1 9
15 GO:0043995 histone acetyltransferase activity (H4-K5 specific) 2.891E-3 9.395E-3 4.263E-2
1.503E-1
 1 9
16 GO:0046972 histone acetyltransferase activity (H4-K16 specific) 2.891E-3 9.395E-3 4.263E-2
1.503E-1
 1 9
17 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 3.853E-3 1.178E-2
5.348E-2
2.003E-1
 1 12
18 GO:0010485 H4 histone acetyltransferase activity 5.134E-3 1.483E-2
6.731E-2
2.670E-1
 1 16
19 GO:0016307 phosphatidylinositol phosphate kinase activity 7.373E-3 2.000E-2
9.077E-2
3.834E-1
 1 23
20 GO:0031683 G-protein beta/gamma-subunit complex binding 7.693E-3 2.000E-2
9.077E-2
4.000E-1
 1 24
21 GO:0046875 ephrin receptor binding 9.289E-3 2.300E-2
1.044E-1
4.830E-1
 1 29
22 GO:0070566 adenylyltransferase activity 9.927E-3 2.346E-2
1.065E-1
5.162E-1
 1 31
23 GO:0043548 phosphatidylinositol 3-kinase binding 1.216E-2 2.749E-2
1.247E-1
6.322E-1
 1 38
24 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1.279E-2 2.772E-2
1.258E-1
6.653E-1
 1 40
25 GO:0004402 histone acetyltransferase activity 1.914E-2 3.747E-2
1.700E-1
9.953E-1
 1 60
26 GO:0030971 receptor tyrosine kinase binding 1.914E-2 3.747E-2
1.700E-1
9.953E-1
 1 60
27 GO:0061733 peptide-lysine-N-acetyltransferase activity 1.946E-2 3.747E-2
1.700E-1
1.000E0
 1 61
28 GO:1990782 protein tyrosine kinase binding 2.104E-2 3.907E-2
1.773E-1
1.000E0
 1 66
29 GO:0034212 peptide N-acetyltransferase activity 2.198E-2 3.942E-2
1.789E-1
1.000E0
 1 69
30 GO:0048029 monosaccharide binding 2.545E-2 4.412E-2
2.002E-1
1.000E0
 1 80
Show 25 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 451 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006661 phosphatidylinositol biosynthetic process 3.062E-8 1.381E-5 9.237E-5 1.381E-5 4 127
2 GO:0046488 phosphatidylinositol metabolic process 1.982E-7 1.972E-5 1.319E-4 8.938E-5 4 202
3 GO:0048015 phosphatidylinositol-mediated signaling 2.272E-7 1.972E-5 1.319E-4 1.025E-4 4 209
4 GO:0046474 glycerophospholipid biosynthetic process 2.316E-7 1.972E-5 1.319E-4 1.044E-4 4 210
5 GO:0048017 inositol lipid-mediated signaling 2.406E-7 1.972E-5 1.319E-4 1.085E-4 4 212
6 GO:0043551 regulation of phosphatidylinositol 3-kinase activity 2.623E-7 1.972E-5 1.319E-4 1.183E-4 3 45
7 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process 3.405E-7 2.168E-5 1.451E-4 1.535E-4 3 49
8 GO:0045017 glycerolipid biosynthetic process 4.021E-7 2.168E-5 1.451E-4 1.814E-4 4 241
9 GO:0043550 regulation of lipid kinase activity 4.327E-7 2.168E-5 1.451E-4 1.951E-4 3 53
10 GO:0008654 phospholipid biosynthetic process 4.808E-7 2.168E-5 1.451E-4 2.168E-4 4 252
11 GO:1903725 regulation of phospholipid metabolic process 8.833E-7 3.622E-5 2.423E-4 3.984E-4 3 67
12 GO:1900076 regulation of cellular response to insulin stimulus 1.053E-6 3.959E-5 2.648E-4 4.751E-4 3 71
13 GO:0006650 glycerophospholipid metabolic process 1.158E-6 4.018E-5 2.688E-4 5.223E-4 4 314
14 GO:0019216 regulation of lipid metabolic process 1.362E-6 4.387E-5 2.935E-4 6.141E-4 4 327
15 GO:0046854 phosphatidylinositol phosphorylation 2.464E-6 7.407E-5 4.955E-4 1.111E-3 3 94
16 GO:0046834 lipid phosphorylation 2.881E-6 8.121E-5 5.433E-4 1.299E-3 3 99
17 GO:0046486 glycerolipid metabolic process 3.257E-6 8.641E-5 5.780E-4 1.469E-3 4 407
18 GO:0006644 phospholipid metabolic process 3.869E-6 9.694E-5 6.485E-4 1.745E-3 4 425
19 GO:0008286 insulin receptor signaling pathway 5.959E-6 1.415E-4 9.463E-4 2.688E-3 3 126
20 GO:2001275 positive regulation of glucose import in response to insulin stimulus 7.859E-6 1.772E-4 1.185E-3 3.544E-3 2 14
21 GO:0014065 phosphatidylinositol 3-kinase signaling 1.389E-5 2.894E-4 1.936E-3 6.263E-3 3 167
22 GO:2001273 regulation of glucose import in response to insulin stimulus 1.476E-5 2.894E-4 1.936E-3 6.655E-3 2 19
23 GO:0044381 glucose import in response to insulin stimulus 1.476E-5 2.894E-4 1.936E-3 6.655E-3 2 19
24 GO:0032869 cellular response to insulin stimulus 2.680E-5 5.035E-4 3.368E-3 1.208E-2 3 208
25 GO:1900078 positive regulation of cellular response to insulin stimulus 2.802E-5 5.054E-4 3.381E-3 1.264E-2 2 26
26 GO:0030258 lipid modification 4.922E-5 8.538E-4 5.712E-3 2.220E-2 3 255
27 GO:0032868 response to insulin 5.582E-5 9.325E-4 6.238E-3 2.518E-2 3 266
28 GO:0046326 positive regulation of glucose import 9.291E-5 1.497E-3 1.001E-2 4.190E-2 2 47
29 GO:0071375 cellular response to peptide hormone stimulus 1.004E-4 1.561E-3 1.044E-2 4.527E-2 3 324
30 GO:1901653 cellular response to peptide 1.158E-4 1.741E-3 1.165E-2
5.223E-2
 3 340
31 GO:0010828 positive regulation of glucose transmembrane transport 1.229E-4 1.788E-3 1.196E-2
5.541E-2
 2 54
32 GO:0046324 regulation of glucose import 2.376E-4 3.348E-3 2.240E-2
1.071E-1
 2 75
33 GO:0043434 response to peptide hormone 2.518E-4 3.441E-3 2.302E-2
1.136E-1
 3 442
34 GO:1901652 response to peptide 3.153E-4 4.182E-3 2.798E-2
1.422E-1
 3 477
35 GO:0046323 glucose import 3.271E-4 4.191E-3 2.804E-2
1.475E-1
 2 88
36 GO:0051897 positive regulation of protein kinase B signaling 3.346E-4 4.191E-3 2.804E-2
1.509E-1
 2 89
37 GO:0010827 regulation of glucose transmembrane transport 5.873E-4 7.159E-3 4.789E-2
2.649E-1
 2 118
38 GO:0051896 regulation of protein kinase B signaling 7.677E-4 9.111E-3
6.095E-2
3.462E-1
 2 135
39 GO:1900182 positive regulation of protein localization to nucleus 8.019E-4 9.274E-3
6.204E-2
3.617E-1
 2 138
40 GO:0001678 cellular glucose homeostasis 1.049E-3 1.183E-2
7.914E-2
4.732E-1
 2 158
41 GO:0043491 protein kinase B signaling 1.089E-3 1.198E-2
8.014E-2
4.912E-1
 2 161
42 GO:0008645 hexose transmembrane transport 1.185E-3 1.243E-2
8.314E-2
5.344E-1
 2 168
43 GO:0030168 platelet activation 1.185E-3 1.243E-2
8.314E-2
5.344E-1
 2 168
44 GO:0015749 monosaccharide transmembrane transport 1.213E-3 1.243E-2
8.318E-2
5.471E-1
 2 170
45 GO:0055118 negative regulation of cardiac muscle contraction 1.288E-3 1.263E-2
8.449E-2
5.810E-1
 1 4
46 GO:0010897 negative regulation of triglyceride catabolic process 1.288E-3 1.263E-2
8.449E-2
5.810E-1
 1 4
47 GO:0006041 glucosamine metabolic process 1.610E-3 1.513E-2
1.012E-1
7.261E-1
 1 5
48 GO:0032252 secretory granule localization 1.610E-3 1.513E-2
1.012E-1
7.261E-1
 1 5
49 GO:0008643 carbohydrate transport 1.825E-3 1.680E-2
1.124E-1
8.232E-1
 2 209
50 GO:0043406 positive regulation of MAP kinase activity 2.243E-3 1.954E-2
1.307E-1
1.000E0
 2 232
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 23 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005942 phosphatidylinositol 3-kinase complex 1.320E-11 3.036E-10 1.134E-9 3.036E-10 4 20
2 GO:0005944 phosphatidylinositol 3-kinase complex, class IB 2.477E-7 2.848E-6 1.064E-5 5.697E-6 2 3
3 GO:0061695 transferase complex, transferring phosphorus-containing groups 3.852E-7 2.953E-6 1.103E-5 8.859E-6 4 244
4 GO:0019898 extrinsic component of membrane 6.492E-7 3.733E-6 1.394E-5 1.493E-5 4 278
5 GO:0097651 phosphatidylinositol 3-kinase complex, class I 8.254E-7 3.797E-6 1.418E-5 1.898E-5 2 5
6 GO:0042629 mast cell granule 7.219E-3 2.475E-2
9.242E-2
1.660E-1
 1 23
7 GO:0042588 zymogen granule 7.532E-3 2.475E-2
9.242E-2
1.732E-1
 1 24
8 GO:0000791 euchromatin 1.253E-2 3.601E-2
1.345E-1
2.881E-1
 1 40
Show 3 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 229 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 4 input genes in category / 139 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008720 impaired neutrophil chemotaxis 1.475E-4 1.367E-2
7.537E-2
 2.050E-2 2 52
2 MP:0008719 impaired neutrophil recruitment 1.966E-4 1.367E-2
7.537E-2
 2.733E-2 2 60
3 MP:0011518 abnormal cell chemotaxis 1.040E-3 4.031E-2
2.223E-1
1.445E-1
 2 138
4 MP:0002463 abnormal neutrophil physiology 1.743E-3 4.031E-2
2.223E-1
2.422E-1
 2 179
5 MP:0000715 decreased thymocyte number 1.880E-3 4.031E-2
2.223E-1
2.614E-1
 2 186
6 MP:0005092 decreased double-positive T cell number 2.086E-3 4.031E-2
2.223E-1
2.899E-1
 2 196
7 MP:0000219 increased neutrophil cell number 2.961E-3 4.031E-2
2.223E-1
4.115E-1
 2 234
8 MP:0002408 abnormal double-positive T cell morphology 3.011E-3 4.031E-2
2.223E-1
4.185E-1
 2 236
9 MP:0004865 abnormal platelet calcium level 3.087E-3 4.031E-2
2.223E-1
4.291E-1
 1 8
10 MP:0004867 decreased platelet calcium level 3.087E-3 4.031E-2
2.223E-1
4.291E-1
 1 8
11 MP:0000278 abnormal myocardial fiber morphology 3.190E-3 4.031E-2
2.223E-1
4.434E-1
 2 243
12 MP:0002462 abnormal granulocyte physiology 3.700E-3 4.286E-2
2.364E-1
5.143E-1
 2 262
13 MP:0008079 decreased CD8-positive, alpha-beta T cell number 4.246E-3 4.540E-2
2.504E-1
5.903E-1
 2 281
14 MP:0010267 decreased lung tumor incidence 4.628E-3 4.595E-2
2.534E-1
6.433E-1
 1 12
Show 9 more annotations

6: Domain [Display Chart] 6 input genes in category / 68 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF16454 PI3K P85 iSH2 Pfam 2.564E-7 8.717E-6 4.188E-5 1.743E-5 2 3
2 IPR032498 PI3K P85 iSH2 InterPro 2.564E-7 8.717E-6 4.188E-5 1.743E-5 2 3
3 IPR001720 PI3kinase P85 InterPro 8.544E-7 1.937E-5 9.304E-5 5.810E-5 2 5
4 IPR029489 OGT/SEC/SPY C InterPro 3.203E-4 2.903E-3 1.395E-2 2.178E-2 1 1
5 PF13844 Glyco transf 41 Pfam 3.203E-4 2.903E-3 1.395E-2 2.178E-2 1 1
6 PF00017 SH2 Pfam 4.256E-4 2.903E-3 1.395E-2 2.894E-2 2 101
7 SM00252 SH2 SMART 5.046E-4 2.903E-3 1.395E-2 3.431E-2 2 110
8 PS50001 SH2 PROSITE 5.138E-4 2.903E-3 1.395E-2 3.494E-2 2 111
9 IPR000980 SH2 InterPro 5.230E-4 2.903E-3 1.395E-2 3.557E-2 2 112
10 3.30.505.10 - Gene3D 5.230E-4 2.903E-3 1.395E-2 3.557E-2 2 112
11 PS51219 DPCK PROSITE 6.404E-4 2.903E-3 1.395E-2 4.355E-2 1 2
12 PF01121 CoaE Pfam 6.404E-4 2.903E-3 1.395E-2 4.355E-2 1 2
13 PF10486 PI3K 1B p101 Pfam 6.404E-4 2.903E-3 1.395E-2 4.355E-2 1 2
14 IPR001977 Depp CoAkinase InterPro 6.404E-4 2.903E-3 1.395E-2 4.355E-2 1 2
15 IPR019522 PIK3R5/6 InterPro 6.404E-4 2.903E-3 1.395E-2 4.355E-2 1 2
16 IPR003113 PI3K adapt-bd dom InterPro 1.281E-3 5.122E-3 2.461E-2
8.707E-2
 1 4
17 PS51544 PI3K ABD PROSITE 1.281E-3 5.122E-3 2.461E-2
8.707E-2
 1 4
18 IPR004821 Cyt trans-like InterPro 2.240E-3 6.216E-3 2.986E-2
1.523E-1
 1 7
19 IPR000341 PI3K Ras-bd dom InterPro 2.240E-3 6.216E-3 2.986E-2
1.523E-1
 1 7
20 PF00794 PI3K rbd Pfam 2.240E-3 6.216E-3 2.986E-2
1.523E-1
 1 7
21 PS51546 PI3K RBD PROSITE 2.240E-3 6.216E-3 2.986E-2
1.523E-1
 1 7
22 SM00144 PI3K rbd SMART 2.240E-3 6.216E-3 2.986E-2
1.523E-1
 1 7
23 PF01467 CTP transf like Pfam 2.240E-3 6.216E-3 2.986E-2
1.523E-1
 1 7
24 PF13414 TPR 11 Pfam 2.240E-3 6.216E-3 2.986E-2
1.523E-1
 1 7
25 SM00142 PI3K C2 SMART 2.560E-3 6.216E-3 2.986E-2
1.741E-1
 1 8
26 PS51547 PI3K C2 PROSITE 2.560E-3 6.216E-3 2.986E-2
1.741E-1
 1 8
27 IPR002420 PI3K C2 dom InterPro 2.560E-3 6.216E-3 2.986E-2
1.741E-1
 1 8
28 PF00792 PI3K C2 Pfam 2.560E-3 6.216E-3 2.986E-2
1.741E-1
 1 8
29 1.25.40.70 - Gene3D 2.879E-3 6.316E-3 3.034E-2
1.958E-1
 1 9
30 SM00145 PI3Ka SMART 2.879E-3 6.316E-3 3.034E-2
1.958E-1
 1 9
31 PF00613 PI3Ka Pfam 2.879E-3 6.316E-3 3.034E-2
1.958E-1
 1 9
32 IPR001263 PInositide-3 kin accessory dom InterPro 3.199E-3 6.397E-3 3.073E-2
2.175E-1
 1 10
33 IPR015433 PI Kinase InterPro 3.199E-3 6.397E-3 3.073E-2
2.175E-1
 1 10
34 PS51545 PIK HELICAL PROSITE 3.199E-3 6.397E-3 3.073E-2
2.175E-1
 1 10
35 IPR018936 PI3/4 kinase CS InterPro 4.795E-3 9.312E-3 4.474E-2
3.261E-1
 1 15
36 1.10.1070.11 - Gene3D 5.114E-3 9.312E-3 4.474E-2
3.477E-1
 1 16
37 SM00146 PI3Kc SMART 5.114E-3 9.312E-3 4.474E-2
3.477E-1
 1 16
38 PF00454 PI3 PI4 kinase Pfam 5.752E-3 9.312E-3 4.474E-2
3.911E-1
 1 18
39 PS50290 PI3 4 KINASE 3 PROSITE 5.752E-3 9.312E-3 4.474E-2
3.911E-1
 1 18
40 IPR000403 PI3/4 kinase cat dom InterPro 5.752E-3 9.312E-3 4.474E-2
3.911E-1
 1 18
41 PS00915 PI3 4 KINASE 1 PROSITE 5.752E-3 9.312E-3 4.474E-2
3.911E-1
 1 18
42 PS00916 PI3 4 KINASE 2 PROSITE 5.752E-3 9.312E-3 4.474E-2
3.911E-1
 1 18
43 IPR014729 Rossmann-like a/b/a fold InterPro 1.369E-2 2.116E-2
1.017E-1
9.312E-1
 1 43
44 3.40.50.620 - Gene3D 1.369E-2 2.116E-2
1.017E-1
9.312E-1
 1 43
45 PF13181 TPR 8 Pfam 1.686E-2 2.547E-2
1.224E-1
1.000E0
 1 53
46 SM00324 RhoGAP SMART 1.969E-2 2.764E-2
1.328E-1
1.000E0
 1 62
47 PF00620 RhoGAP Pfam 2.001E-2 2.764E-2
1.328E-1
1.000E0
 1 63
48 PS50238 RHOGAP PROSITE 2.032E-2 2.764E-2
1.328E-1
1.000E0
 1 64
49 1.10.555.10 - Gene3D 2.032E-2 2.764E-2
1.328E-1
1.000E0
 1 64
50 IPR000198 RhoGAP dom InterPro 2.032E-2 2.764E-2
1.328E-1
1.000E0
 1 64
Show 45 more annotations

7: Pathway [Display Chart] 6 input genes in category / 217 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 545314 3-phosphoinositide biosynthesis BioSystems: BIOCYC 2.623E-10 4.443E-8 2.648E-7 5.692E-8 4 27
2 P00009 Axon guidance mediated by netrin PantherDB 4.095E-10 4.443E-8 2.648E-7 8.885E-8 4 30
3 P00033 Insulin/IGF pathway-protein kinase B signaling cascade PantherDB 6.926E-10 5.009E-8 2.985E-7 1.503E-7 4 34
4 P04398 p53 pathway feedback loops 2 PantherDB 2.222E-9 1.154E-7 6.879E-7 4.821E-7 4 45
5 1269581 G beta:gamma signalling through PI3Kgamma BioSystems: REACTOME 2.900E-9 1.154E-7 6.879E-7 6.294E-7 4 48
6 1270077 Synthesis of PIPs at the plasma membrane BioSystems: REACTOME 3.432E-9 1.154E-7 6.879E-7 7.448E-7 4 50
7 1269580 G-protein beta:gamma signalling BioSystems: REACTOME 3.724E-9 1.154E-7 6.879E-7 8.080E-7 4 51
8 1269357 GPVI-mediated activation cascade BioSystems: REACTOME 4.711E-9 1.278E-7 7.615E-7 1.022E-6 4 54
9 547492 superpathway of inositol phosphate compounds BioSystems: BIOCYC 1.072E-8 2.584E-7 1.540E-6 2.326E-6 4 66
10 P00019 Endothelin signaling pathway PantherDB 1.617E-8 3.509E-7 2.091E-6 3.509E-6 4 73
11 1270073 PI Metabolism BioSystems: REACTOME 2.231E-8 4.034E-7 2.404E-6 4.841E-6 4 79
12 P00059 p53 pathway PantherDB 2.231E-8 4.034E-7 2.404E-6 4.841E-6 4 79
13 217716 Cholinergic synapse BioSystems: KEGG 9.182E-8 1.533E-6 9.134E-6 1.992E-5 4 112
14 952858 Platelet activation BioSystems: KEGG 1.340E-7 2.077E-6 1.238E-5 2.908E-5 4 123
15 P00047 PDGF signaling pathway PantherDB 1.525E-7 2.184E-6 1.302E-5 3.309E-5 4 127
16 P00030 Hypoxia response via HIF activation PantherDB 1.610E-7 2.184E-6 1.302E-5 3.495E-5 3 26
17 1311074 Phospholipase D signaling pathway BioSystems: KEGG 2.673E-7 3.413E-6 2.034E-5 5.801E-5 4 146
18 P00048 PI3 kinase pathway PantherDB 1.067E-6 1.263E-5 7.529E-5 2.316E-4 3 48
19 1270053 Phospholipid metabolism BioSystems: REACTOME 1.106E-6 1.263E-5 7.529E-5 2.400E-4 4 208
20 P00056 VEGF signaling pathway PantherDB 1.900E-6 2.062E-5 1.229E-4 4.123E-4 3 58
21 1269350 Platelet activation, signaling and aggregation BioSystems: REACTOME 3.730E-6 3.854E-5 2.297E-4 8.094E-4 4 282
22 P00053 T cell activation PantherDB 4.315E-6 4.256E-5 2.536E-4 9.364E-4 3 76
23 692234 PI3K-Akt signaling pathway BioSystems: KEGG 8.035E-6 7.581E-5 4.518E-4 1.744E-3 4 342
24 1272486 Insulin resistance BioSystems: KEGG 1.211E-5 1.095E-4 6.528E-4 2.629E-3 3 107
25 1269324 Regulation of signaling by CBL BioSystems: REACTOME 2.951E-5 2.562E-4 1.527E-3 6.404E-3 2 18
26 P00005 Angiogenesis PantherDB 3.339E-5 2.787E-4 1.661E-3 7.245E-3 3 150
27 1269179 CD28 dependent PI3K/Akt signaling BioSystems: REACTOME 4.452E-5 3.567E-4 2.126E-3 9.661E-3 2 22
28 P00034 Integrin signalling pathway PantherDB 4.603E-5 3.567E-4 2.126E-3 9.988E-3 3 167
29 1269326 Interleukin-7 signaling BioSystems: REACTOME 7.276E-5 5.444E-4 3.245E-3 1.579E-2 2 28
30 1269178 CD28 co-stimulation BioSystems: REACTOME 1.015E-4 7.344E-4 4.376E-3 2.203E-2 2 33
31 PW:0000232 phosphatidylinositol 3-kinase-Akt signaling Pathway Ontology 1.078E-4 7.549E-4 4.499E-3 2.340E-2 2 34
32 130626 Aldosterone-regulated sodium reabsorption BioSystems: KEGG 1.279E-4 8.676E-4 5.171E-3 2.776E-2 2 37
33 170720 Carbohydrate digestion and absorption BioSystems: KEGG 1.815E-4 1.193E-3 7.111E-3 3.938E-2 2 44
34 M5193 Genes related to chemotaxis MSigDB C2 BIOCARTA (v6.0) 1.899E-4 1.212E-3 7.222E-3 4.120E-2 2 45
35 83094 Type II diabetes mellitus BioSystems: KEGG 1.985E-4 1.230E-3 7.333E-3 4.306E-2 2 46
36 83109 Endometrial cancer BioSystems: KEGG 2.347E-4 1.415E-3 8.430E-3
5.093E-2
 2 50
37 1222950 Regulation of lipolysis in adipocytes BioSystems: KEGG 2.739E-4 1.606E-3 9.574E-3
5.944E-2
 2 54
38 83117 Acute myeloid leukemia BioSystems: KEGG 2.842E-4 1.623E-3 9.671E-3
6.167E-2
 2 55
39 83119 Non-small cell lung cancer BioSystems: KEGG 3.161E-4 1.759E-3 1.048E-2
6.860E-2
 2 58
40 83066 VEGF signaling pathway BioSystems: KEGG 3.272E-4 1.775E-3 1.058E-2
7.099E-2
 2 59
41 83106 Colorectal cancer BioSystems: KEGG 3.384E-4 1.791E-3 1.067E-2
7.343E-2
 2 60
42 1340713 Longevity regulating pathway - multiple species BioSystems: KEGG 3.613E-4 1.834E-3 1.093E-2
7.841E-2
 2 62
43 83108 Pancreatic cancer BioSystems: KEGG 3.851E-4 1.834E-3 1.093E-2
8.356E-2
 2 64
44 83110 Glioma BioSystems: KEGG 3.851E-4 1.834E-3 1.093E-2
8.356E-2
 2 64
45 83107 Renal cell carcinoma BioSystems: KEGG 3.972E-4 1.834E-3 1.093E-2
8.619E-2
 2 65
46 1059538 Central carbon metabolism in cancer BioSystems: KEGG 3.972E-4 1.834E-3 1.093E-2
8.619E-2
 2 65
47 1268880 Constitutive Signaling by Aberrant PI3K in Cancer BioSystems: REACTOME 3.972E-4 1.834E-3 1.093E-2
8.619E-2
 2 65
48 83082 Fc epsilon RI signaling pathway BioSystems: KEGG 4.347E-4 1.965E-3 1.171E-2
9.434E-2
 2 68
49 83114 Melanoma BioSystems: KEGG 4.476E-4 1.978E-3 1.179E-2
9.713E-2
 2 69
50 814182 Prolactin signaling pathway BioSystems: KEGG 4.607E-4 1.978E-3 1.179E-2
9.997E-2
 2 70
Show 45 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 1105 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17041586 Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Pubmed 2.057E-8 9.739E-6 7.387E-5 2.273E-5 2 2
2 26173259 Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity. Pubmed 2.057E-8 9.739E-6 7.387E-5 2.273E-5 2 2
3 15797027 p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. Pubmed 6.170E-8 9.739E-6 7.387E-5 6.817E-5 2 3
4 25605974 The regulatory subunits of PI3Kγ control distinct neutrophil responses. Pubmed 6.170E-8 9.739E-6 7.387E-5 6.817E-5 2 3
5 10358071 Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits. Pubmed 6.170E-8 9.739E-6 7.387E-5 6.817E-5 2 3
6 10488142 Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus. Pubmed 6.170E-8 9.739E-6 7.387E-5 6.817E-5 2 3
7 15611065 Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma. Pubmed 6.170E-8 9.739E-6 7.387E-5 6.817E-5 2 3
8 11172806 Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations. Pubmed 2.056E-7 2.272E-5 1.723E-4 2.272E-4 2 5
9 20038597 Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4. Pubmed 2.056E-7 2.272E-5 1.723E-4 2.272E-4 2 5
10 7624799 Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Pubmed 2.056E-7 2.272E-5 1.723E-4 2.272E-4 2 5
11 7542745 The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Pubmed 3.084E-7 2.840E-5 2.154E-4 3.408E-4 2 6
12 10949031 Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival. Pubmed 3.084E-7 2.840E-5 2.154E-4 3.408E-4 2 6
13 9178903 Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK. Pubmed 4.318E-7 3.670E-5 2.784E-4 4.771E-4 2 7
14 17846664 Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase. Pubmed 5.756E-7 3.975E-5 3.015E-4 6.361E-4 2 8
15 12507995 Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. Pubmed 5.756E-7 3.975E-5 3.015E-4 6.361E-4 2 8
16 22402981 Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Pubmed 5.756E-7 3.975E-5 3.015E-4 6.361E-4 2 8
17 21765914 Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat. Pubmed 7.400E-7 4.164E-5 3.158E-4 8.177E-4 2 9
18 12470648 Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. Pubmed 7.400E-7 4.164E-5 3.158E-4 8.177E-4 2 9
19 9247029 Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity. Pubmed 9.250E-7 4.164E-5 3.158E-4 1.022E-3 2 10
20 20598684 Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells. Pubmed 9.250E-7 4.164E-5 3.158E-4 1.022E-3 2 10
21 8798481 Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. Pubmed 9.250E-7 4.164E-5 3.158E-4 1.022E-3 2 10
22 8636073 The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1. Pubmed 9.250E-7 4.164E-5 3.158E-4 1.022E-3 2 10
23 9113989 P110delta, a novel phosphoinositide 3-kinase in leukocytes. Pubmed 9.250E-7 4.164E-5 3.158E-4 1.022E-3 2 10
24 9062339 The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts. Pubmed 9.250E-7 4.164E-5 3.158E-4 1.022E-3 2 10
25 16081599 HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways. Pubmed 1.130E-6 4.164E-5 3.158E-4 1.249E-3 2 11
26 9708406 HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells. Pubmed 1.130E-6 4.164E-5 3.158E-4 1.249E-3 2 11
27 12584329 Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells. Pubmed 1.130E-6 4.164E-5 3.158E-4 1.249E-3 2 11
28 9808187 Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. Pubmed 1.130E-6 4.164E-5 3.158E-4 1.249E-3 2 11
29 25104021 HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway. Pubmed 1.130E-6 4.164E-5 3.158E-4 1.249E-3 2 11
30 10985305 HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line. Pubmed 1.130E-6 4.164E-5 3.158E-4 1.249E-3 2 11
31 10208934 HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes. Pubmed 1.356E-6 4.283E-5 3.248E-4 1.499E-3 2 12
32 12551992 Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages. Pubmed 1.356E-6 4.283E-5 3.248E-4 1.499E-3 2 12
33 14602571 Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells. Pubmed 1.356E-6 4.283E-5 3.248E-4 1.499E-3 2 12
34 12077252 Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism. Pubmed 1.356E-6 4.283E-5 3.248E-4 1.499E-3 2 12
35 9341793 Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. Pubmed 1.356E-6 4.283E-5 3.248E-4 1.499E-3 2 12
36 23215766 HIV-1 Nef in macrophage-mediated disease pathogenesis. Pubmed 1.603E-6 4.787E-5 3.631E-4 1.771E-3 2 13
37 9394803 Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. Pubmed 1.603E-6 4.787E-5 3.631E-4 1.771E-3 2 13
38 17157319 Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line. Pubmed 1.870E-6 5.438E-5 4.125E-4 2.066E-3 2 14
39 20702582 Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action. Pubmed 2.158E-6 5.960E-5 4.521E-4 2.384E-3 2 15
40 18854243 HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex. Pubmed 2.158E-6 5.960E-5 4.521E-4 2.384E-3 2 15
41 11289809 HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway. Pubmed 2.466E-6 6.192E-5 4.697E-4 2.724E-3 2 16
42 16524887 HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45. Pubmed 2.466E-6 6.192E-5 4.697E-4 2.724E-3 2 16
43 20019835 Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice. Pubmed 2.466E-6 6.192E-5 4.697E-4 2.724E-3 2 16
44 20818790 Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders. Pubmed 2.466E-6 6.192E-5 4.697E-4 2.724E-3 2 16
45 23251686 Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes. Pubmed 2.794E-6 6.569E-5 4.983E-4 3.088E-3 2 17
46 12960231 Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. Pubmed 2.794E-6 6.569E-5 4.983E-4 3.088E-3 2 17
47 18453587 Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages. Pubmed 2.794E-6 6.569E-5 4.983E-4 3.088E-3 2 17
48 12526811 HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. Pubmed 3.143E-6 7.236E-5 5.489E-4 3.473E-3 2 18
49 24073214 HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation. Pubmed 3.513E-6 7.922E-5 6.009E-4 3.882E-3 2 19
50 9446795 Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. Pubmed 4.313E-6 9.532E-5 7.231E-4 4.766E-3 2 21
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 386 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PIK3CD PIK3CD interactions 2.092E-8 8.075E-6 5.276E-5 8.075E-6 3 19
2 int:PIK3R5 PIK3R5 interactions 2.009E-6 3.877E-4 2.533E-3 7.754E-4 2 7
3 int:FPR1 FPR1 interactions 3.443E-6 4.430E-4 2.894E-3 1.329E-3 2 9
4 int:FLRT1 FLRT1 interactions 1.299E-5 1.254E-3 8.191E-3 5.014E-3 2 17
5 int:CD28 CD28 interactions 2.005E-5 1.548E-3 1.011E-2 7.738E-3 2 21
6 int:KRT20 KRT20 interactions 3.871E-5 2.269E-3 1.483E-2 1.494E-2 2 29
7 int:AXL AXL interactions 4.727E-5 2.269E-3 1.483E-2 1.825E-2 2 32
8 int:TMEM52B TMEM52B interactions 5.668E-5 2.269E-3 1.483E-2 2.188E-2 2 35
9 int:HEPACAM2 HEPACAM2 interactions 6.693E-5 2.269E-3 1.483E-2 2.584E-2 2 38
10 int:PIK3CG PIK3CG interactions 6.693E-5 2.269E-3 1.483E-2 2.584E-2 2 38
11 int:CBL CBL interactions 6.858E-5 2.269E-3 1.483E-2 2.647E-2 3 271
12 int:TEC TEC interactions 7.054E-5 2.269E-3 1.483E-2 2.723E-2 2 39
13 int:GNG2 GNG2 interactions 7.804E-5 2.317E-3 1.514E-2 3.012E-2 2 41
14 int:PIK3CB PIK3CB interactions 1.118E-4 3.082E-3 2.014E-2 4.315E-2 2 49
15 int:VSIG4 VSIG4 interactions 1.972E-4 4.758E-3 3.109E-2
7.613E-2
 2 65
16 int:IRS2 IRS2 interactions 1.972E-4 4.758E-3 3.109E-2
7.613E-2
 2 65
17 int:HAVCR2 HAVCR2 interactions 2.159E-4 4.903E-3 3.203E-2
8.334E-2
 2 68
18 int:KIT KIT interactions 2.698E-4 5.786E-3 3.781E-2
1.041E-1
 2 76
19 int:EFNB2 EFNB2 interactions 2.915E-4 5.923E-3 3.870E-2
1.125E-1
 2 79
20 int:HCK HCK interactions 3.953E-4 7.630E-3 4.986E-2
1.526E-1
 2 92
21 int:SKAP1 SKAP1 interactions 4.485E-4 7.796E-3
5.094E-2
1.731E-1
 2 98
22 int:BCR BCR interactions 4.669E-4 7.796E-3
5.094E-2
1.802E-1
 2 100
23 int:PPME1 PPME1 interactions 4.669E-4 7.796E-3
5.094E-2
1.802E-1
 2 100
24 int:IRS1 IRS1 interactions 4.953E-4 7.796E-3
5.094E-2
1.912E-1
 2 103
25 int:TGFBR2 TGFBR2 interactions 5.049E-4 7.796E-3
5.094E-2
1.949E-1
 2 104
26 int:PDGFRB PDGFRB interactions 5.749E-4 8.535E-3
5.577E-2
2.219E-1
 2 111
27 int:SOCS6 SOCS6 interactions 6.494E-4 9.021E-3
5.895E-2
2.507E-1
 2 118
28 int:PIK3CA PIK3CA interactions 6.715E-4 9.021E-3
5.895E-2
2.592E-1
 2 120
29 int:PIK3R6 PIK3R6 interactions 6.778E-4 9.021E-3
5.895E-2
2.616E-1
 1 2
30 int:IRS4 IRS4 interactions 7.167E-4 9.209E-3
6.018E-2
2.767E-1
 2 124
31 int:PIK3R3 PIK3R3 interactions 7.399E-4 9.209E-3
6.018E-2
2.856E-1
 2 126
32 int:GNB1 GNB1 interactions 7.634E-4 9.209E-3
6.018E-2
2.947E-1
 2 128
33 int:PIK3R2 PIK3R2 interactions 8.239E-4 9.637E-3
6.297E-2
3.180E-1
 2 133
34 int:SYK SYK interactions 8.866E-4 1.007E-2
6.577E-2
3.422E-1
 2 138
35 int:CRKL CRKL interactions 9.253E-4 1.020E-2
6.668E-2
3.571E-1
 2 141
36 int:SEC14L2 SEC14L2 interactions 1.016E-3 1.060E-2
6.929E-2
3.924E-1
 1 3
37 int:ZNF767P ZNF767P interactions 1.016E-3 1.060E-2
6.929E-2
3.924E-1
 1 3
38 int:IGF1R IGF1R interactions 1.131E-3 1.149E-2
7.506E-2
4.365E-1
 2 156
39 int:CRYBA2 CRYBA2 interactions 1.355E-3 1.308E-2
8.545E-2
5.231E-1
 1 4
40 int:PLEKHS1 PLEKHS1 interactions 1.355E-3 1.308E-2
8.545E-2
5.231E-1
 1 4
41 int:SERF1A SERF1A interactions 1.694E-3 1.486E-2
9.709E-2
6.538E-1
 1 5
42 int:HCFC1R1 HCFC1R1 interactions 1.694E-3 1.486E-2
9.709E-2
6.538E-1
 1 5
43 int:ERAS ERAS interactions 1.694E-3 1.486E-2
9.709E-2
6.538E-1
 1 5
44 int:METTL27 METTL27 interactions 1.694E-3 1.486E-2
9.709E-2
6.538E-1
 1 5
45 int:ERBB3 ERBB3 interactions 1.759E-3 1.509E-2
9.858E-2
6.789E-1
 2 195
46 int:PACRGL PACRGL interactions 2.032E-3 1.705E-2
1.114E-1
7.844E-1
 1 6
47 int:TUBA1C TUBA1C interactions 2.333E-3 1.759E-2
1.149E-1
9.003E-1
 2 225
48 int:ENKUR ENKUR interactions 2.370E-3 1.759E-2
1.149E-1
9.150E-1
 1 7
49 int:RBP7 RBP7 interactions 2.370E-3 1.759E-2
1.149E-1
9.150E-1
 1 7
50 int:TNNC2 TNNC2 interactions 2.370E-3 1.759E-2
1.149E-1
9.150E-1
 1 7
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19q13.2-q13.4 19q13.2-q13.4 5.192E-4 3.115E-3 7.633E-3 3.115E-3 1 3
2 Xq13 Xq13 2.421E-3 7.264E-3 1.780E-2 1.453E-2 1 14
3 7q22.3 7q22.3 3.975E-3 7.950E-3 1.948E-2 2.385E-2 1 23
4 17q12-q21 17q12-q21 5.527E-3 8.290E-3 2.031E-2 3.316E-2 1 32
5 1p34.1 1p34.1 9.827E-3 1.179E-2 2.889E-2
5.896E-2
 1 57
6 17p13.1 17p13.1 2.094E-2 2.094E-2
5.129E-2
1.256E-1
 1 122
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 82 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 4 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 741 SH2 domain containing genenames.org 1.818E-4 7.270E-4 1.515E-3 7.270E-4 2 101
2 446 O-linked N-acetylglucosaminyltransferases genenames.org 8.792E-4 1.758E-3 3.663E-3 3.517E-3 1 4
3 831 Phosphatidylinositol 3-kinase subunits genenames.org 1.758E-3 2.344E-3 4.883E-3 7.031E-3 1 8
4 769 Anaphase promoting complex |Tetratricopeptide repeat domain containing genenames.org 2.505E-2 2.505E-2
5.218E-2
1.002E-1
 1 115

13: Coexpression [Display Chart] 6 input genes in category / 708 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20460173-ImmPortNaturalKillerCellCytotoxicity Human Immune Kong10 135genes ImmPort NaturalKillerCellCytotoxicity GeneSigDB 1.247E-8 8.830E-6 6.305E-5 8.830E-6 4 126
2 M8777 Genes down-regulated in dendritic cells: wildtype versus NLRP10 [GeneID=338322] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 4.419E-3 3.156E-2 8.839E-3 3 200
3 12738660-TableS2 Human Leukemia Yagi03 135genes GeneSigDB 4.013E-4 2.270E-2
1.621E-1
2.841E-1
 2 121
4 M18887 Genes differentially expressed in pediatric AML (acute myeloid leukemia) samples from patients with good survival (>3 years without relapse) compared to those with poor survival (relapsed within one year after treatment). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.489E-4 2.270E-2
1.621E-1
3.179E-1
 2 128
5 20436685-ST6-2 Human Breast Pothuri10 180genes GeneSigDB 7.622E-4 2.270E-2
1.621E-1
5.396E-1
 2 167
6 M6326 Genes up-regulated in spleen from wildtype mice: control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 8.082E-4 2.270E-2
1.621E-1
5.722E-1
 2 172
7 M5354 Genes required for proliferation of DLD-1 cell (colon cancer with APC [GeneID=324] deletions), based on shRNA screen. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.364E-4 2.270E-2
1.621E-1
5.922E-1
 2 175
8 M6717 Genes down-regulated in endothelial cells: B. burgdoferi versus IFNG [GeneID=3459] and B. burgdoferi . MSigDB C7: Immunologic Signatures (v6.0) 8.651E-4 2.270E-2
1.621E-1
6.125E-1
 2 178
9 M7631 Genes up-regulated in CD8 T cells: naïve versus 2' memory. MSigDB C7: Immunologic Signatures (v6.0) 8.845E-4 2.270E-2
1.621E-1
6.262E-1
 2 180
10 M6807 Genes up-regulated in B lymphocytes treated by anti-HEL and expressing BCR [GeneID=613] fusions with: IgM versus IgMG. MSigDB C7: Immunologic Signatures (v6.0) 9.440E-4 2.270E-2
1.621E-1
6.683E-1
 2 186
11 16585155-TableS1 Human Colon Watanabe06 214genes GeneSigDB 1.005E-3 2.270E-2
1.621E-1
7.118E-1
 2 192
12 M9509 Genes up-regulated in CD8 T cells: naïve versus exhausted at day 30 chronic infection with LCMV-clone 13. MSigDB C7: Immunologic Signatures (v6.0) 1.037E-3 2.270E-2
1.621E-1
7.340E-1
 2 195
13 M5150 Genes up-regulated in comparison of dendritic cells (DC) versus DCs exposed to B. malayi (50 worms/well). MSigDB C7: Immunologic Signatures (v6.0) 1.069E-3 2.270E-2
1.621E-1
7.565E-1
 2 198
14 M5145 Genes up-regulated in untreated dendritic cells (DC) versus DCs exposed to parasite L. major. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.270E-2
1.621E-1
7.641E-1
 2 199
15 M8774 Genes down-regulated in dendritic cells: control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.270E-2
1.621E-1
7.641E-1
 2 199
16 M7981 Genes up-regulated in wildtype bone marrow-derived macrophages treated with IL4 [GeneID=3565]: control versus rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
17 M7713 Genes up-regulated in bone marrow-derived dendritic cellstreated by poly(IC): 0h versus 3h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
18 M7648 Genes up-regulated in CD4 [GeneID=920] T cells under germ free conditions: healthy versus arthritis (KRN model). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
19 M8656 Genes down-regulated in bone marrow-derived macrophages: interferon alpha versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
20 M6667 Genes down-regulated in bone marrow-derived macrophagesat 180 min stimulation by LPS: IL6 [GeneID=3469] knockout versus IL10 [GeneID=3486] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
21 M6029 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (48h) versus IL4 [GeneID=3565] (48h). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
22 M6414 Genes down-regulated in monocytes (3h): untreated versus M. tuberculosis 19 kDa lipopeptide. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
23 M5921 Genes encoding components of the complement system, which is part of the innate immune system. MSigDB H: Hallmark Gene Sets (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
24 M8115 Genes up-regulated in IL10 [GeneID=3586] knockout macrophages stimulated by IL10 [GeneID=3586] versus NFKB1 [GeneID=4790] knockout macrophages stimulated by IL10 [GeneID=3586] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
25 M5192 Genes up-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to L. major. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
26 M8389 Genes down-regulated in brain microglia versus bone marrow monocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
27 M3628 Genes down-regulated in comparison of unstimulated CD8 T cells at 24 h versus CD8 T cells at 24 h after treatment with trichostatin A (TSA) [PubChem=5562]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
28 M9851 Genes down-regulated in CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4intermediate versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
29 M4964 Genes down-regulated in comparison of monocytes from influenza vaccinee at day 7 post-vaccination versus plasmacytoid dendritic cells (mDC) at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
30 M5673 Genes up-regulated in comparison of TconvLN versus TregLN (see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
31 M5848 Genes up-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] versus monocytes treated with anti-TREM1 [GeneID=54210] and 5000 ng/ml LPS (TLR4 agonist). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
32 M7780 Genes down-regulated macrophages with MYD88 [GeneID=4615] knockout: untreated versus 12h after M. bovis BCG infection. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
33 M4659 Genes down-regulated in comparison of naive CD8 T cells versus PD-1 low CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
34 M5204 Genes down-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to 5 worm/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.270E-2
1.621E-1
7.718E-1
 2 200
35 M5076 Genes specifically up-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and high dose methotrexate (HDMTX) [PubChem=4112]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.296E-3 2.622E-2
1.872E-1
9.176E-1
 1 5
36 19530251 suppinfo7 Human Breast Rozenchan09 7genes GeneSigDB 1.555E-3 3.058E-2
2.184E-1
1.000E0
 1 6
37 19674463-Table2 Human Breast Roepman09 13genes GeneSigDB 1.814E-3 3.471E-2
2.479E-1
1.000E0
 1 7
Show 32 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 317 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Large Intestine/Brush cell of epithelium proper of large intestine Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Large Intestine/Brush cell of epithelium proper of large intestine Tabula Muris Consortium 1.260E-4 2.745E-2
1.739E-1
 3.993E-2 2 64
2 PP epoMEP 500 K5 PP epoMEP top-relative-expression-ranked 500 k-means-cluster#5 PCBC 1.732E-4 2.745E-2
1.739E-1
5.489E-2
 2 75
3 PP MEP 500 K3 PP MEP top-relative-expression-ranked 500 k-means-cluster#3 PCBC 3.079E-4 2.952E-2
1.871E-1
9.762E-2
 2 100
4 PP HSC 500 K1 PP HSC top-relative-expression-ranked 500 k-means-cluster#1 PCBC 3.725E-4 2.952E-2
1.871E-1
1.181E-1
 2 110
5 PP MEG 500 K1 PP MEG top-relative-expression-ranked 500 k-means-cluster#1 PCBC 7.094E-4 3.773E-2
2.391E-1
2.249E-1
 2 152
6 gudmap dev gonad e13.5 F SupCellPrec Sry k2 500 dev gonad e13.5 F SupCellPrec Sry k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.953E-4 3.773E-2
2.391E-1
2.521E-1
 2 161
7 Mouse Cell Atlas Mouse Regional GI Enterocytes Tuft Tuft Overall Top 200 Genes Mouse Cell Atlas Mouse Regional GI Enterocytes Tuft Tuft Overall Top 200 Genes Mouse Cell Atlas 1.026E-3 3.773E-2
2.391E-1
3.251E-1
 2 183
8 PP epoMEP 1000 K5 PP epoMEP top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 1.070E-3 3.773E-2
2.391E-1
3.393E-1
 2 187
9 PP GMP 1000 K4 PP GMP top-relative-expression-ranked 1000 k-means-cluster#4 PCBC 1.175E-3 3.773E-2
2.391E-1
3.725E-1
 2 196
10 PP HSC 1000 K2 PP HSC top-relative-expression-ranked 1000 k-means-cluster#2 PCBC 1.199E-3 3.773E-2
2.391E-1
3.800E-1
 2 198
11 Lungmap Mouse Lung PND3 Myeloid Subtype Myeloid-A Lungmap Mouse Lung PND3 Myeloid Subtype Myeloid-A Lungmap CCHMC 1.309E-3 3.773E-2
2.391E-1
4.150E-1
 2 207
Show 6 more annotations

15: Computational [Display Chart] 5 input genes in category / 14 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 6 input genes in category / 354 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GGCAGAC,MIR-346:MSigDB GGCAGAC,MIR-346:MSigDB MSigDB 4.254E-6 8.778E-4 5.660E-3 1.506E-3 2 39
2 hsa-miR-26a-5p:Functional MTI Functional MTI miRTarbase 4.959E-6 8.778E-4 5.660E-3 1.756E-3 3 457
3 hsa-miR-126-3p:Functional MTI Functional MTI miRTarbase 9.156E-6 1.080E-3 6.966E-3 3.241E-3 2 57
4 hsa-miR-548g-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.558E-5 2.264E-3 1.460E-2 9.055E-3 2 95
5 hsa-miR-382-3p:TargetScan hsa-miR-382-3p TargetScan 1.069E-4 7.031E-3 4.534E-2 3.783E-2 2 194
6 hsa-miR-125a-5p:Functional MTI Functional MTI miRTarbase 2.067E-4 7.031E-3 4.534E-2
7.317E-2
 2 270
7 GTGCAAT,MIR-32:MSigDB GTGCAAT,MIR-32:MSigDB MSigDB 2.367E-4 7.031E-3 4.534E-2
8.380E-2
 2 289
8 GTGCAAT,MIR-367:MSigDB GTGCAAT,MIR-367:MSigDB MSigDB 2.367E-4 7.031E-3 4.534E-2
8.380E-2
 2 289
9 GTGCAAT,MIR-92:MSigDB GTGCAAT,MIR-92:MSigDB MSigDB 2.367E-4 7.031E-3 4.534E-2
8.380E-2
 2 289
10 GTGCAAT,MIR-363:MSigDB GTGCAAT,MIR-363:MSigDB MSigDB 2.367E-4 7.031E-3 4.534E-2
8.380E-2
 2 289
11 GTGCAAT,MIR-25:MSigDB GTGCAAT,MIR-25:MSigDB MSigDB 2.367E-4 7.031E-3 4.534E-2
8.380E-2
 2 289
12 hsa-miR-605:PITA hsa-miR-605:PITA TOP PITA 2.383E-4 7.031E-3 4.534E-2
8.437E-2
 2 290
13 hsa-miR-126:PITA hsa-miR-126:PITA TOP PITA 3.322E-4 7.981E-3
5.146E-2
1.176E-1
 1 4
14 hsa-miR-34b:PITA hsa-miR-34b:PITA TOP PITA 4.061E-4 7.981E-3
5.146E-2
1.438E-1
 2 379
15 hsa-miR-601:mirSVR highEffct hsa-miR-601:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.082E-4 7.981E-3
5.146E-2
1.445E-1
 2 380
16 hsa-miR-148b-3p:Functional MTI Functional MTI miRTarbase 4.588E-4 7.981E-3
5.146E-2
1.624E-1
 2 403
17 hsa-miR-7-5p:TargetScan hsa-miR-7-5p TargetScan 4.633E-4 7.981E-3
5.146E-2
1.640E-1
 2 405
18 hsa-miR-331-3p:Functional MTI Functional MTI miRTarbase 4.656E-4 7.981E-3
5.146E-2
1.648E-1
 2 406
19 hsa-miR-27a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.195E-4 7.981E-3
5.146E-2
1.839E-1
 2 429
20 TGAATGT,MIR-181A:MSigDB TGAATGT,MIR-181A:MSigDB MSigDB 6.096E-4 7.981E-3
5.146E-2
2.158E-1
 2 465
21 TGAATGT,MIR-181B:MSigDB TGAATGT,MIR-181B:MSigDB MSigDB 6.096E-4 7.981E-3
5.146E-2
2.158E-1
 2 465
22 TGAATGT,MIR-181D:MSigDB TGAATGT,MIR-181D:MSigDB MSigDB 6.096E-4 7.981E-3
5.146E-2
2.158E-1
 2 465
23 TGAATGT,MIR-181C:MSigDB TGAATGT,MIR-181C:MSigDB MSigDB 6.096E-4 7.981E-3
5.146E-2
2.158E-1
 2 465
24 hsa-miR-4308:mirSVR highEffct hsa-miR-4308:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.466E-4 7.981E-3
5.146E-2
2.289E-1
 2 479
25 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 6.574E-4 7.981E-3
5.146E-2
2.327E-1
 2 483
26 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 6.574E-4 7.981E-3
5.146E-2
2.327E-1
 2 483
27 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 6.574E-4 7.981E-3
5.146E-2
2.327E-1
 2 483
28 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 6.574E-4 7.981E-3
5.146E-2
2.327E-1
 2 483
29 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 6.574E-4 7.981E-3
5.146E-2
2.327E-1
 2 483
30 hsa-miR-641:PITA hsa-miR-641:PITA TOP PITA 6.764E-4 7.981E-3
5.146E-2
2.394E-1
 2 490
31 AACGGTT,MIR-451:MSigDB AACGGTT,MIR-451:MSigDB MSigDB 9.133E-4 1.043E-2
6.725E-2
3.233E-1
 1 11
32 AGCGCAG,MIR-191:MSigDB AGCGCAG,MIR-191:MSigDB MSigDB 9.963E-4 1.102E-2
7.107E-2
3.527E-1
 1 12
33 hsa-miR-126:mirSVR highEffct hsa-miR-126:mirSVR conserved highEffect-0.5 MicroRNA.org 1.328E-3 1.425E-2
9.187E-2
4.702E-1
 1 16
34 hsa-miR-126-3p.2:TargetScan hsa-miR-126-3p.2 TargetScan 2.158E-3 2.246E-2
1.448E-1
7.638E-1
 1 26
35 hsa-miR-127-3p:Functional MTI Functional MTI miRTarbase 2.406E-3 2.434E-2
1.569E-1
8.518E-1
 1 29
36 hsa-miR-1282:PITA hsa-miR-1282:PITA TOP PITA 2.489E-3 2.448E-2
1.578E-1
8.812E-1
 1 30
37 hsa-miR-3619-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.572E-3 2.461E-2
1.587E-1
9.105E-1
 1 31
38 hsa-miR-4776-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.821E-3 2.628E-2
1.694E-1
9.985E-1
 1 34
39 hsa-miR-4761-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.649E-3 2.923E-2
1.885E-1
1.000E0
 1 44
40 hsa-miR-1256:Non-Functional MTI Non-Functional MTI miRTarbase 3.815E-3 2.923E-2
1.885E-1
1.000E0
 1 46
41 hsa-miR-3689f:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.063E-3 2.923E-2
1.885E-1
1.000E0
 1 49
42 hsa-miR-5591-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.063E-3 2.923E-2
1.885E-1
1.000E0
 1 49
43 hsa-miR-3689b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 2.923E-2
1.885E-1
1.000E0
 1 50
44 GTCAGGA,MIR-378:MSigDB GTCAGGA,MIR-378:MSigDB MSigDB 4.146E-3 2.923E-2
1.885E-1
1.000E0
 1 50
45 hsa-miR-3689e:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 2.923E-2
1.885E-1
1.000E0
 1 50
46 hsa-miR-3689a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 2.923E-2
1.885E-1
1.000E0
 1 50
47 hsa-miR-4482-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.311E-3 2.923E-2
1.885E-1
1.000E0
 1 52
48 hsa-miR-3130-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.311E-3 2.923E-2
1.885E-1
1.000E0
 1 52
49 ATAACCT,MIR-154:MSigDB ATAACCT,MIR-154:MSigDB MSigDB 4.642E-3 2.923E-2
1.885E-1
1.000E0
 1 56
50 hsa-miR-193a-5p:Functional MTI Functional MTI miRTarbase 4.725E-3 2.923E-2
1.885E-1
1.000E0
 1 57
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 1562 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000354197 4-hydroxyisoleucine Stitch 1.804E-12 2.819E-9 2.236E-8 2.819E-9 4 15
2 CID000107935 deguelin Stitch 4.496E-10 3.511E-7 2.785E-6 7.023E-7 4 55
3 CID000065238 pentagalloylglucose Stitch 8.919E-10 4.644E-7 3.683E-6 1.393E-6 4 65
4 CID000064945 ursolic acid Stitch 1.355E-9 5.290E-7 4.195E-6 2.116E-6 4 72
5 CID000370346 halenaquinone Stitch 3.662E-9 1.044E-6 8.278E-6 5.720E-6 3 14
6 CID000001771 5-HETE Stitch 4.009E-9 1.044E-6 8.278E-6 6.262E-6 4 94
7 CID003005531 FTI-277 Stitch 6.525E-9 1.456E-6 1.155E-5 1.019E-5 4 106
8 CID000123015 AC1L3VO5 Stitch 9.399E-9 1.835E-6 1.455E-5 1.468E-5 4 116
9 CID006442177 everolimus Stitch 1.787E-8 2.791E-6 2.214E-5 2.791E-5 4 136
10 CID000000932 naringenin Stitch 1.787E-8 2.791E-6 2.214E-5 2.791E-5 4 136
11 CID000004010 AC1L1H7K Stitch 2.251E-8 3.196E-6 2.535E-5 3.515E-5 4 144
12 CID000643963 PI(3,4,5)P3 Stitch 2.513E-8 3.272E-6 2.595E-5 3.926E-5 4 148
13 CID000020392 monomethyl phthalate Stitch 3.107E-8 3.733E-6 2.961E-5 4.854E-5 4 156
14 CID000148191 NSC-683864 Stitch 4.088E-8 4.561E-6 3.618E-5 6.386E-5 4 167
15 CID000003894 lavendustin A Stitch 4.497E-8 4.683E-6 3.714E-5 7.024E-5 4 171
16 CID005280443 apigenin Stitch 6.038E-8 5.894E-6 4.675E-5 9.431E-5 4 184
17 CID000001413 12(S)-hydroxyeicosatetraenoic acid Stitch 6.725E-8 6.179E-6 4.901E-5 1.050E-4 4 189
18 CID000004813 AC1L1J0H Stitch 7.943E-8 6.665E-6 5.286E-5 1.241E-4 4 197
19 CID006857406 AC1OAGKB Stitch 8.107E-8 6.665E-6 5.286E-5 1.266E-4 4 198
20 CID000000076 ITdU Stitch 3.847E-7 2.884E-5 2.287E-4 6.009E-4 4 292
21 CID006857724 platensimycin Stitch 3.976E-7 2.884E-5 2.287E-4 6.210E-4 3 63
22 CID000002505 C2-ceramide Stitch 4.062E-7 2.884E-5 2.287E-4 6.345E-4 4 296
23 CID000001915 8-bromoguanosine 3',5'-cyclic monophosphate Stitch 4.762E-7 3.133E-5 2.485E-4 7.438E-4 4 308
24 CID000004605 nsc25485 Stitch 5.014E-7 3.133E-5 2.485E-4 7.831E-4 4 312
25 CID000114835 Se-methylselenocysteine Stitch 5.015E-7 3.133E-5 2.485E-4 7.834E-4 3 68
26 CID000008973 3-O-methyl-D-glucose Stitch 5.966E-7 3.457E-5 2.742E-4 9.319E-4 3 72
27 CID000004829 pioglitazone Stitch 5.975E-7 3.457E-5 2.742E-4 9.333E-4 4 326
28 CID000000544 arsenite Stitch 7.667E-7 4.277E-5 3.392E-4 1.198E-3 4 347
29 CID011979316 vasopressin Stitch 1.197E-6 6.024E-5 4.778E-4 1.870E-3 4 388
30 DB01064 Isoproterenol Drug Bank 1.207E-6 6.024E-5 4.778E-4 1.885E-3 2 7
31 CID000054454 simvastatin Stitch 1.222E-6 6.024E-5 4.778E-4 1.909E-3 4 390
32 CID000091176 cnicin Stitch 1.254E-6 6.024E-5 4.778E-4 1.958E-3 3 92
33 CID000001103 spermine Stitch 1.273E-6 6.024E-5 4.778E-4 1.988E-3 4 394
34 CID000000965 mangrove Stitch 2.526E-6 1.161E-4 9.206E-4 3.946E-3 4 468
35 CID000001673 3-methyladenine Stitch 3.898E-6 1.740E-4 1.380E-3 6.089E-3 3 134
36 CID000166548 Anidulafungin Stitch 6.276E-6 2.723E-4 2.160E-3 9.803E-3 3 157
37 CID011647372 ZSTK474 Stitch 7.807E-6 3.296E-4 2.614E-3 1.219E-2 2 17
38 CID000643964 PtdIns(3)P Stitch 8.694E-6 3.517E-4 2.790E-3 1.358E-2 3 175
39 CID011977753 NVP-BEZ235 Stitch 8.782E-6 3.517E-4 2.790E-3 1.372E-2 2 18
40 CID009849735 PX-866 Stitch 1.090E-5 4.258E-4 3.377E-3 1.703E-2 2 20
41 CID000001701 AEBSF Stitch 1.130E-5 4.305E-4 3.415E-3 1.765E-2 3 191
42 CID006857413 AC1OAGKW Stitch 1.166E-5 4.336E-4 3.439E-3 1.821E-2 3 193
43 CID000164073 Pkcs Stitch 1.523E-5 5.532E-4 4.388E-3 2.379E-2 3 211
44 ctd:C531198 dactolisib CTD 2.842E-5 9.866E-4 7.825E-3 4.440E-2 2 32
45 CID009884685 PI-103 Stitch 2.842E-5 9.866E-4 7.825E-3 4.440E-2 2 32
46 CID000002399 BiM4 Stitch 3.661E-5 1.243E-3 9.861E-3
5.719E-2
 3 283
47 CID000000604 gluconate Stitch 3.818E-5 1.269E-3 1.006E-2
5.964E-2
 3 287
48 CID000002548 AC1L1DXE Stitch 4.314E-5 1.404E-3 1.113E-2
6.738E-2
 3 299
49 CID000065167 POPC Stitch 4.622E-5 1.473E-3 1.169E-2
7.219E-2
 3 306
50 CID010995375 CHEMBL459685 Stitch 4.928E-5 1.540E-3 1.221E-2
7.698E-2
 2 42
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 433 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C2720434 Macroencephaly DisGeNET BeFree 1.038E-5 4.493E-3 2.987E-2 4.493E-3 2 14
2 C0221355 Macrocephaly DisGeNET Curated 8.856E-5 1.781E-2
1.184E-1
 3.835E-2 2 40
3 C0266464 Polymicrogyria DisGeNET Curated 3.049E-4 1.781E-2
1.184E-1
1.320E-1
 2 74
4 cv:CN184649 Neurodegeneration with brain iron accumulation 6 Clinical Variations 3.703E-4 1.781E-2
1.184E-1
1.603E-1
 1 1
5 cv:CN169372 Ataxia-oculomotor apraxia 3 Clinical Variations 3.703E-4 1.781E-2
1.184E-1
1.603E-1
 1 1
6 cv:C1863924 Megalencephaly polymicrogyria-polydactyly hydrocephalus syndrome Clinical Variations 3.703E-4 1.781E-2
1.184E-1
1.603E-1
 1 1
7 C3810230 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 6 DisGeNET Curated 3.703E-4 1.781E-2
1.184E-1
1.603E-1
 1 1
8 C4012727 MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 1 DisGeNET Curated 3.703E-4 1.781E-2
1.184E-1
1.603E-1
 1 1
9 C2243051 Large head (disorder) DisGeNET BeFree 3.703E-4 1.781E-2
1.184E-1
1.603E-1
 1 1
10 C0151468 Thyroid Gland Follicular Adenoma DisGeNET Curated 6.368E-4 2.709E-2
1.801E-1
2.757E-1
 2 107
11 C0342346 Pseudohypoparathyroidism and pseudopseudohypoparathyroidism DisGeNET BeFree 7.404E-4 2.709E-2
1.801E-1
3.206E-1
 1 2
12 C0349639 Juvenile Myelomonocytic Leukemia DisGeNET Curated 7.607E-4 2.709E-2
1.801E-1
3.294E-1
 2 117
13 C1301034 Pancreatic intraepithelial neoplasia DisGeNET BeFree 8.133E-4 2.709E-2
1.801E-1
3.522E-1
 2 121
14 C4020968 Abnormal localization of kidney DisGeNET Curated 1.110E-3 3.052E-2
2.030E-1
4.808E-1
 1 3
15 C1835194 Thick corpus callosum DisGeNET Curated 1.110E-3 3.052E-2
2.030E-1
4.808E-1
 1 3
16 C1857790 Thoracic scoliosis DisGeNET Curated 1.480E-3 3.052E-2
2.030E-1
6.410E-1
 1 4
17 C3554690 ATAXIA-OCULOMOTOR APRAXIA 3 DisGeNET Curated 1.480E-3 3.052E-2
2.030E-1
6.410E-1
 1 4
18 C1333431 Epstein-Barr Virus-Related Lymphoma DisGeNET BeFree 1.480E-3 3.052E-2
2.030E-1
6.410E-1
 1 4
19 C0271270 Oculovestibuloauditory syndrome DisGeNET BeFree 1.480E-3 3.052E-2
2.030E-1
6.410E-1
 1 4
20 C1863924 Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome DisGeNET Curated 1.480E-3 3.052E-2
2.030E-1
6.410E-1
 1 4
21 C4041147 Acute exacerbation of chronic obstructive bronchitis DisGeNET BeFree 1.480E-3 3.052E-2
2.030E-1
6.410E-1
 1 4
22 C0595989 Carcinoma of larynx DisGeNET Curated 1.615E-3 3.081E-2
2.049E-1
6.993E-1
 2 171
23 C0677936 Refractory cancer DisGeNET BeFree 1.653E-3 3.081E-2
2.049E-1
7.155E-1
 2 173
24 C3714976 ACTIVATED PI3K-DELTA SYNDROME DisGeNET Curated 1.850E-3 3.081E-2
2.049E-1
8.011E-1
 1 5
25 C1845668 Perisylvian syndrome DisGeNET Curated 1.850E-3 3.081E-2
2.049E-1
8.011E-1
 1 5
26 C0334348 Papillary hidradenoma DisGeNET BeFree 1.850E-3 3.081E-2
2.049E-1
8.011E-1
 1 5
27 C0948380 Colorectal cancer metastatic DisGeNET BeFree 1.927E-3 3.091E-2
2.055E-1
8.345E-1
 2 187
28 C0585187 Infected ascites DisGeNET BeFree 2.220E-3 3.101E-2
2.062E-1
9.612E-1
 1 6
29 C4055466 Angiosarcoma of Soft Tissue DisGeNET BeFree 2.220E-3 3.101E-2
2.062E-1
9.612E-1
 1 6
30 C0221214 Vascular ring DisGeNET Curated 2.220E-3 3.101E-2
2.062E-1
9.612E-1
 1 6
31 C0813148 Metastatic Endometrial Carcinoma DisGeNET BeFree 2.220E-3 3.101E-2
2.062E-1
9.612E-1
 1 6
32 C0404484 Chronic pelvic pain of female DisGeNET BeFree 2.589E-3 3.149E-2
2.093E-1
1.000E0
 1 7
33 C0279663 Serous cystadenocarcinoma ovary DisGeNET BeFree 2.589E-3 3.149E-2
2.093E-1
1.000E0
 1 7
34 C0220633 Uveal melanoma DisGeNET Curated 2.655E-3 3.149E-2
2.093E-1
1.000E0
 2 220
35 C1851584 Familial ependymoma DisGeNET BeFree 2.959E-3 3.149E-2
2.093E-1
1.000E0
 1 8
36 C2931826 Potassium aggravated myotonia DisGeNET Curated 2.959E-3 3.149E-2
2.093E-1
1.000E0
 1 8
37 C0878684 SHORT syndrome DisGeNET Curated 2.959E-3 3.149E-2
2.093E-1
1.000E0
 1 8
38 C0265326 Bannayan-Riley-Ruvalcaba Syndrome DisGeNET Curated 2.959E-3 3.149E-2
2.093E-1
1.000E0
 1 8
39 C0917798 Cerebral Ischemia DisGeNET Curated 2.972E-3 3.149E-2
2.093E-1
1.000E0
 2 233
40 C4280603 Increased size of palpebral fissures DisGeNET Curated 3.328E-3 3.149E-2
2.093E-1
1.000E0
 1 9
41 C3263719 Primary acquired melanosis DisGeNET BeFree 3.328E-3 3.149E-2
2.093E-1
1.000E0
 1 9
42 C1855852 Large eyes DisGeNET Curated 3.328E-3 3.149E-2
2.093E-1
1.000E0
 1 9
43 C1959582 PTEN Hamartoma Tumor Syndrome DisGeNET BeFree 3.328E-3 3.149E-2
2.093E-1
1.000E0
 1 9
44 C0006111 Brain Diseases DisGeNET Curated 3.360E-3 3.149E-2
2.093E-1
1.000E0
 2 248
45 C0007785 Cerebral Infarction DisGeNET Curated 3.659E-3 3.149E-2
2.093E-1
1.000E0
 2 259
46 C0862878 Dedifferentiated chondrosarcoma DisGeNET BeFree 3.697E-3 3.149E-2
2.093E-1
1.000E0
 1 10
47 C0279593 B-cell adult acute lymphoblastic leukemia DisGeNET BeFree 3.697E-3 3.149E-2
2.093E-1
1.000E0
 1 10
48 C0238198 Gastrointestinal Stromal Tumors DisGeNET Curated 3.969E-3 3.149E-2
2.093E-1
1.000E0
 2 270
49 C0023801 Lipomatosis DisGeNET Curated 4.067E-3 3.149E-2
2.093E-1
1.000E0
 1 11
50 C0021847 Intestinal Pseudo-Obstruction DisGeNET Curated 4.067E-3 3.149E-2
2.093E-1
1.000E0
 1 11
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