Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc389_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 21 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1.224E-4 2.569E-3 9.367E-3 2.569E-3 2 66
2 GO:0042826 histone deacetylase binding 3.655E-4 2.604E-3 9.491E-3 7.676E-3 2 114
3 GO:0001046 core promoter sequence-specific DNA binding 3.720E-4 2.604E-3 9.491E-3 7.811E-3 2 115
4 GO:0001047 core promoter binding 7.544E-4 3.961E-3 1.444E-2 1.584E-2 2 164
5 GO:0017151 DEAD/H-box RNA helicase binding 1.607E-3 6.748E-3 2.460E-2 3.374E-2 1 6
6 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 3.669E-3 1.284E-2 4.681E-2
7.705E-2
 2 365
7 GO:0000987 proximal promoter sequence-specific DNA binding 4.348E-3 1.304E-2 4.755E-2
9.131E-2
 2 398
8 GO:0071837 HMG box domain binding 6.148E-3 1.530E-2
5.577E-2
1.291E-1
 1 23
9 GO:0001103 RNA polymerase II repressing transcription factor binding 7.481E-3 1.530E-2
5.577E-2
1.571E-1
 1 28
10 GO:0035035 histone acetyltransferase binding 8.013E-3 1.530E-2
5.577E-2
1.683E-1
 1 30
11 GO:0043425 bHLH transcription factor binding 8.013E-3 1.530E-2
5.577E-2
1.683E-1
 1 30
12 GO:0070491 repressing transcription factor binding 1.597E-2 2.796E-2
1.019E-1
3.355E-1
 1 60
13 GO:0035326 enhancer binding 2.808E-2 4.371E-2
1.593E-1
5.898E-1
 1 106
14 GO:0001078 proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific 3.018E-2 4.371E-2
1.593E-1
6.337E-1
 1 114
15 GO:0001085 RNA polymerase II transcription factor binding 3.122E-2 4.371E-2
1.593E-1
6.557E-1
 1 118
Show 10 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 97 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043353 enucleate erythrocyte differentiation 1.614E-6 7.827E-5 4.036E-4 1.565E-4 2 8
2 GO:0060136 embryonic process involved in female pregnancy 1.614E-6 7.827E-5 4.036E-4 1.565E-4 2 8
3 GO:0002244 hematopoietic progenitor cell differentiation 8.045E-6 2.601E-4 1.341E-3 7.803E-4 3 175
4 GO:0001829 trophectodermal cell differentiation 1.456E-5 3.348E-4 1.727E-3 1.412E-3 2 23
5 GO:0060216 definitive hemopoiesis 1.726E-5 3.348E-4 1.727E-3 1.674E-3 2 25
6 GO:0048596 embryonic camera-type eye morphogenesis 2.673E-5 4.322E-4 2.229E-3 2.593E-3 2 31
7 GO:0048048 embryonic eye morphogenesis 4.480E-5 5.329E-4 2.748E-3 4.346E-3 2 40
8 GO:0001825 blastocyst formation 4.709E-5 5.329E-4 2.748E-3 4.568E-3 2 41
9 GO:0031076 embryonic camera-type eye development 4.944E-5 5.329E-4 2.748E-3 4.796E-3 2 42
10 GO:0030219 megakaryocyte differentiation 7.904E-5 7.666E-4 3.954E-3 7.666E-3 2 53
11 GO:0001503 ossification 9.811E-5 8.651E-4 4.461E-3 9.516E-3 3 404
12 GO:0001701 in utero embryonic development 1.078E-4 8.713E-4 4.494E-3 1.046E-2 3 417
13 GO:0048568 embryonic organ development 1.627E-4 1.214E-3 6.261E-3 1.578E-2 3 479
14 GO:0001824 blastocyst development 2.288E-4 1.492E-3 7.694E-3 2.219E-2 2 90
15 GO:1904826 regulation of hydrogen sulfide biosynthetic process 2.685E-4 1.492E-3 7.694E-3 2.604E-2 1 1
16 GO:0100057 regulation of phenotypic switching by transcription from RNA polymerase II promoter 2.685E-4 1.492E-3 7.694E-3 2.604E-2 1 1
17 GO:1904828 positive regulation of hydrogen sulfide biosynthetic process 2.685E-4 1.492E-3 7.694E-3 2.604E-2 1 1
18 GO:0001892 embryonic placenta development 2.769E-4 1.492E-3 7.694E-3 2.686E-2 2 99
19 GO:0030218 erythrocyte differentiation 3.606E-4 1.841E-3 9.494E-3 3.498E-2 2 113
20 GO:0034101 erythrocyte homeostasis 4.271E-4 2.071E-3 1.068E-2 4.143E-2 2 123
21 GO:0048593 camera-type eye morphogenesis 4.697E-4 2.169E-3 1.119E-2 4.556E-2 2 129
22 GO:0048706 embryonic skeletal system development 5.218E-4 2.301E-3 1.187E-2
5.062E-2
 2 136
23 GO:0002262 myeloid cell homeostasis 6.259E-4 2.640E-3 1.361E-2
6.071E-2
 2 149
24 GO:0001890 placenta development 7.667E-4 2.992E-3 1.543E-2
7.437E-2
 2 165
25 GO:0001889 liver development 8.041E-4 2.992E-3 1.543E-2
7.800E-2
 2 169
26 GO:1900239 regulation of phenotypic switching 8.053E-4 2.992E-3 1.543E-2
7.811E-2
 1 3
27 GO:0061008 hepaticobiliary system development 8.327E-4 2.992E-3 1.543E-2
8.077E-2
 2 172
28 GO:0048592 eye morphogenesis 8.716E-4 3.020E-3 1.557E-2
8.455E-2
 2 176
29 GO:0036166 phenotypic switching 1.074E-3 3.591E-3 1.852E-2
1.041E-1
 1 4
30 GO:0007565 female pregnancy 1.321E-3 4.151E-3 2.141E-2
1.281E-1
 2 217
31 GO:0070814 hydrogen sulfide biosynthetic process 1.342E-3 4.151E-3 2.141E-2
1.302E-1
 1 5
32 GO:0030324 lung development 1.369E-3 4.151E-3 2.141E-2
1.328E-1
 2 221
33 GO:0030323 respiratory tube development 1.419E-3 4.170E-3 2.151E-2
1.376E-1
 2 225
34 GO:0044706 multi-multicellular organism process 1.748E-3 4.924E-3 2.539E-2
1.695E-1
 2 250
35 GO:0060541 respiratory system development 1.803E-3 4.924E-3 2.539E-2
1.749E-1
 2 254
36 GO:0051176 positive regulation of sulfur metabolic process 1.878E-3 4.924E-3 2.539E-2
1.822E-1
 1 7
37 GO:0070813 hydrogen sulfide metabolic process 1.878E-3 4.924E-3 2.539E-2
1.822E-1
 1 7
38 GO:0048872 homeostasis of number of cells 2.140E-3 5.463E-3 2.817E-2
2.076E-1
 2 277
39 GO:0090596 sensory organ morphogenesis 2.439E-3 6.067E-3 3.129E-2
2.366E-1
 2 296
40 GO:0048562 embryonic organ morphogenesis 2.950E-3 7.154E-3 3.689E-2
2.862E-1
 2 326
41 GO:0043010 camera-type eye development 3.186E-3 7.432E-3 3.833E-2
3.090E-1
 2 339
42 GO:0043923 positive regulation by host of viral transcription 3.218E-3 7.432E-3 3.833E-2
3.121E-1
 1 12
43 GO:0030099 myeloid cell differentiation 4.153E-3 9.295E-3 4.793E-2
4.028E-1
 2 388
44 GO:0001654 eye development 4.216E-3 9.295E-3 4.793E-2
4.090E-1
 2 391
45 GO:0042789 mRNA transcription by RNA polymerase II 4.556E-3 9.608E-3 4.955E-2
4.420E-1
 1 17
46 GO:0060218 hematopoietic stem cell differentiation 4.556E-3 9.608E-3 4.955E-2
4.420E-1
 1 17
47 GO:0052472 modulation by host of symbiont transcription 5.626E-3 1.114E-2
5.744E-2
5.457E-1
 1 21
48 GO:0043921 modulation by host of viral transcription 5.626E-3 1.114E-2
5.744E-2
5.457E-1
 1 21
49 GO:0042762 regulation of sulfur metabolic process 5.626E-3 1.114E-2
5.744E-2
5.457E-1
 1 21
50 GO:0052312 modulation of transcription in other organism involved in symbiotic interaction 5.893E-3 1.143E-2
5.896E-2
5.717E-1
 1 22
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 7 annotations before applied cutoff / 19061 genes in category

No results to display

4: Human Phenotype [Display Chart] 1 input genes in category / 55 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0005005 Femoral bowing present at birth, straightening with time 2.124E-3 3.389E-2
1.557E-1
1.168E-1
 1 10
2 HP:0003321 Biconcave flattened vertebrae 2.124E-3 3.389E-2
1.557E-1
1.168E-1
 1 10
3 HP:0003023 Bowing of limbs due to multiple fractures 2.974E-3 3.389E-2
1.557E-1
1.636E-1
 1 14
4 HP:0000362 Otosclerosis 3.612E-3 3.389E-2
1.557E-1
1.986E-1
 1 17
5 HP:0010299 Abnormality of dentin 4.674E-3 3.389E-2
1.557E-1
2.571E-1
 1 22
6 HP:0000703 Dentinogenesis imperfecta 4.674E-3 3.389E-2
1.557E-1
2.571E-1
 1 22
7 HP:0008628 Abnormality of the stapes 4.886E-3 3.389E-2
1.557E-1
2.687E-1
 1 23
8 HP:0040160 Generalized osteoporosis 5.736E-3 3.389E-2
1.557E-1
3.155E-1
 1 27
9 HP:0004452 Abnormality of the middle ear ossicles 5.949E-3 3.389E-2
1.557E-1
3.272E-1
 1 28
10 HP:0004586 Biconcave vertebral bodies 6.161E-3 3.389E-2
1.557E-1
3.389E-1
 1 29
11 HP:0008609 Morphological abnormality of the middle ear 7.436E-3 3.603E-2
1.655E-1
4.090E-1
 1 35
12 HP:0000336 Prominent supraorbital ridges 7.861E-3 3.603E-2
1.655E-1
4.323E-1
 1 37
13 HP:0002980 Femoral bowing 1.147E-2 4.590E-2
2.109E-1
6.310E-1
 1 54
14 HP:0002645 Wormian bones 1.168E-2 4.590E-2
2.109E-1
6.427E-1
 1 55
Show 9 more annotations

5: Mouse Phenotype [Display Chart] 5 input genes in category / 220 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0010128 hypovolemia 3.914E-6 2.951E-4 1.763E-3 8.610E-4 2 7
2 MP:0012109 decreased trophoblast glycogen cell number 3.914E-6 2.951E-4 1.763E-3 8.610E-4 2 7
3 MP:0008958 abnormal trophoblast glycogen cell morphology 5.217E-6 2.951E-4 1.763E-3 1.148E-3 2 8
4 MP:0011525 abnormal placenta intervillous maternal lacunae morphology 6.706E-6 2.951E-4 1.763E-3 1.475E-3 2 9
5 MP:0011527 disorganized placental labyrinth 6.706E-6 2.951E-4 1.763E-3 1.475E-3 2 9
6 MP:0001599 abnormal blood volume 1.694E-5 6.210E-4 3.709E-3 3.726E-3 2 14
7 MP:0008959 abnormal spongiotrophoblast cell morphology 2.232E-5 7.016E-4 4.191E-3 4.911E-3 2 16
8 MP:0012099 decreased spongiotrophoblast size 2.845E-5 7.824E-4 4.674E-3 6.260E-3 2 18
9 MP:0012097 abnormal spongiotrophoblast size 6.516E-5 1.543E-3 9.219E-3 1.434E-2 2 27
10 MP:0004921 decreased placenta weight 7.016E-5 1.543E-3 9.219E-3 1.543E-2 2 28
11 MP:0004257 abnormal placenta weight 1.040E-4 1.919E-3 1.146E-2 2.288E-2 2 34
12 MP:0004200 decreased fetal size 1.047E-4 1.919E-3 1.146E-2 2.303E-2 3 230
13 MP:0004198 abnormal fetal size 1.173E-4 1.986E-3 1.186E-2 2.581E-2 3 239
14 MP:0011109 lethality throughout fetal growth and development, incomplete penetrance 1.358E-4 2.133E-3 1.274E-2 2.987E-2 3 251
15 MP:0004197 abnormal fetal growth/weight/body size 2.590E-4 3.799E-3 2.269E-2
5.698E-2
 3 312
16 MP:0011083 lethality at weaning, complete penetrance 3.952E-4 5.114E-3 3.055E-2
8.694E-2
 2 66
17 MP:0004255 abnormal spongiotrophoblast layer morphology 3.952E-4 5.114E-3 3.055E-2
8.694E-2
 2 66
18 MP:0001786 skin edema 4.320E-4 5.241E-3 3.130E-2
9.504E-2
 2 69
19 MP:0008957 abnormal placenta junctional zone morphology 4.574E-4 5.241E-3 3.130E-2
1.006E-1
 2 71
20 MP:0008973 decreased erythroid progenitor cell number 5.241E-4 5.241E-3 3.130E-2
1.153E-1
 2 76
21 MP:0008395 abnormal osteoblast differentiation 5.241E-4 5.241E-3 3.130E-2
1.153E-1
 2 76
22 MP:0004259 small placenta 5.241E-4 5.241E-3 3.130E-2
1.153E-1
 2 76
23 MP:0009431 decreased fetal weight 5.806E-4 5.554E-3 3.317E-2
1.277E-1
 2 80
24 MP:0008989 abnormal liver sinusoid morphology 6.553E-4 6.007E-3 3.588E-2
1.442E-1
 2 85
25 MP:0008271 abnormal bone ossification 7.487E-4 6.353E-3 3.795E-2
1.647E-1
 3 447
26 MP:0005306 abnormal phalanx morphology 7.508E-4 6.353E-3 3.795E-2
1.652E-1
 2 91
27 MP:0003402 decreased liver weight 8.010E-4 6.526E-3 3.898E-2
1.762E-1
 2 94
28 MP:0004258 abnormal placenta size 9.060E-4 7.119E-3 4.252E-2
1.993E-1
 2 100
29 MP:0004124 abnormal Purkinje fiber morphology 9.655E-4 7.325E-3 4.375E-2
2.124E-1
 1 2
30 MP:0008569 lethality at weaning 1.037E-3 7.602E-3 4.540E-2
2.280E-1
 2 107
31 MP:0008801 abnormal erythroid progenitor cell morphology 1.302E-3 9.239E-3
5.518E-2
2.864E-1
 2 120
32 MP:0009820 abnormal liver vasculature morphology 1.389E-3 9.552E-3
5.705E-2
3.057E-1
 2 124
33 MP:0001293 anophthalmia 1.480E-3 9.864E-3
5.892E-2
3.255E-1
 2 128
34 MP:0008272 abnormal endochondral bone ossification 1.843E-3 1.192E-2
7.123E-2
4.054E-1
 2 143
35 MP:0000245 abnormal erythropoiesis 1.973E-3 1.240E-2
7.406E-2
4.340E-1
 2 148
36 MP:0005031 abnormal trophoblast layer morphology 2.079E-3 1.271E-2
7.590E-2
4.575E-1
 2 152
37 MP:0004986 abnormal osteoblast morphology 2.301E-3 1.368E-2
8.173E-2
5.063E-1
 2 160
38 MP:0001716 abnormal placenta labyrinth morphology 3.263E-3 1.889E-2
1.128E-1
7.178E-1
 2 191
39 MP:0002896 abnormal bone mineralization 3.714E-3 2.095E-2
1.251E-1
8.171E-1
 2 204
40 MP:0020083 decreased hippocampus volume 3.858E-3 2.122E-2
1.267E-1
8.487E-1
 1 8
41 MP:0011705 absent fibroblast proliferation 4.339E-3 2.297E-2
1.372E-1
9.546E-1
 1 9
42 MP:0000601 small liver 4.385E-3 2.297E-2
1.372E-1
9.646E-1
 2 222
43 MP:0003717 pallor 4.580E-3 2.343E-2
1.400E-1
1.000E0
 2 227
44 MP:0008275 failure of endochondral bone ossification 4.820E-3 2.410E-2
1.440E-1
1.000E0
 1 10
45 MP:0004847 abnormal liver weight 4.943E-3 2.417E-2
1.443E-1
1.000E0
 2 236
46 MP:0008987 abnormal liver lobule morphology 5.192E-3 2.483E-2
1.483E-1
1.000E0
 2 242
47 MP:0008986 abnormal liver parenchyma morphology 5.751E-3 2.596E-2
1.551E-1
1.000E0
 2 255
48 MP:0004337 clavicle hypoplasia 5.782E-3 2.596E-2
1.551E-1
1.000E0
 1 12
49 MP:0020394 decreased neuronal precursor proliferation 5.782E-3 2.596E-2
1.551E-1
1.000E0
 1 12
50 MP:0001191 abnormal skin condition 6.338E-3 2.747E-2
1.641E-1
1.000E0
 2 268
Show 45 more annotations

6: Domain [Display Chart] 5 input genes in category / 3 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR030450 Sp1 fam InterPro 1.311E-17 3.932E-17 7.210E-17 3.932E-17 5 10
2 IPR030451 SP2 TF InterPro 2.669E-4 2.669E-4 4.893E-4 8.006E-4 1 1
3 IPR030453 SP4 InterPro 2.669E-4 2.669E-4 4.893E-4 8.006E-4 1 1

7: Pathway [Display Chart] 2 input genes in category / 43 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3430 Effects of calcineurin in Keratinocyte Differentiation MSigDB C2 BIOCARTA (v6.0) 2.207E-6 9.488E-5 4.127E-4 9.488E-5 2 19
2 137987 Regulation of Telomerase BioSystems: Pathway Interaction Database 2.768E-5 5.951E-4 2.589E-3 1.190E-3 2 66
3 M8353 Human Cytomegalovirus and Map Kinase Pathways MSigDB C2 BIOCARTA (v6.0) 2.729E-3 1.982E-2
8.623E-2
1.174E-1
 1 17
4 1339110 SUMOylation of transcription factors BioSystems: REACTOME 2.729E-3 1.982E-2
8.623E-2
1.174E-1
 1 17
5 137988 IL2 signaling events mediated by STAT5 BioSystems: Pathway Interaction Database 4.814E-3 1.982E-2
8.623E-2
2.070E-1
 1 30
6 1270427 Oncogene Induced Senescence BioSystems: REACTOME 5.134E-3 1.982E-2
8.623E-2
2.208E-1
 1 32
7 169349 Validated transcriptional targets of AP1 family members Fra1 and Fra2 BioSystems: Pathway Interaction Database 5.455E-3 1.982E-2
8.623E-2
2.345E-1
 1 34
8 1269528 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription BioSystems: REACTOME 5.455E-3 1.982E-2
8.623E-2
2.345E-1
 1 34
9 137956 HIF-2-alpha transcription factor network BioSystems: Pathway Interaction Database 5.455E-3 1.982E-2
8.623E-2
2.345E-1
 1 34
10 M6220 Agrin in Postsynaptic Differentiation MSigDB C2 BIOCARTA (v6.0) 5.775E-3 1.982E-2
8.623E-2
2.483E-1
 1 36
11 137935 FOXM1 transcription factor network BioSystems: Pathway Interaction Database 5.935E-3 1.982E-2
8.623E-2
2.552E-1
 1 37
12 1270039 Activation of gene expression by SREBF (SREBP) BioSystems: REACTOME 6.736E-3 1.982E-2
8.623E-2
2.896E-1
 1 42
13 137979 FOXA1 transcription factor network BioSystems: Pathway Interaction Database 6.896E-3 1.982E-2
8.623E-2
2.965E-1
 1 43
14 137911 FOXA2 and FOXA3 transcription factor networks BioSystems: Pathway Interaction Database 7.056E-3 1.982E-2
8.623E-2
3.034E-1
 1 44
15 M19118 Keratinocyte Differentiation MSigDB C2 BIOCARTA (v6.0) 7.376E-3 1.982E-2
8.623E-2
3.172E-1
 1 46
16 1269527 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer BioSystems: REACTOME 7.376E-3 1.982E-2
8.623E-2
3.172E-1
 1 46
17 1270038 Regulation of cholesterol biosynthesis by SREBP (SREBF) BioSystems: REACTOME 8.816E-3 1.989E-2
8.654E-2
3.791E-1
 1 55
18 M2404 Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) MSigDB C2 BIOCARTA (v6.0) 9.296E-3 1.989E-2
8.654E-2
3.997E-1
 1 58
19 169353 Validated targets of C-MYC transcriptional repression BioSystems: Pathway Interaction Database 9.776E-3 1.989E-2
8.654E-2
4.204E-1
 1 61
20 137933 IL4-mediated signaling events BioSystems: Pathway Interaction Database 1.010E-2 1.989E-2
8.654E-2
4.341E-1
 1 63
21 138045 HIF-1-alpha transcription factor network BioSystems: Pathway Interaction Database 1.041E-2 1.989E-2
8.654E-2
4.478E-1
 1 65
22 1496831 Mitophagy - animal BioSystems: KEGG 1.041E-2 1.989E-2
8.654E-2
4.478E-1
 1 65
23 1383088 RNA polymerase II transcribes snRNA genes BioSystems: REACTOME 1.169E-2 1.989E-2
8.654E-2
5.028E-1
 1 73
24 137934 E2F transcription factor network BioSystems: Pathway Interaction Database 1.169E-2 1.989E-2
8.654E-2
5.028E-1
 1 73
25 1269523 Signaling by TGF-beta Receptor Complex BioSystems: REACTOME 1.233E-2 1.989E-2
8.654E-2
5.303E-1
 1 77
26 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 1.233E-2 1.989E-2
8.654E-2
5.303E-1
 1 77
27 138073 C-MYB transcription factor network BioSystems: Pathway Interaction Database 1.249E-2 1.989E-2
8.654E-2
5.371E-1
 1 78
28 83064 TGF-beta signaling pathway BioSystems: KEGG 1.345E-2 2.065E-2
8.983E-2
5.783E-1
 1 84
29 M13863 MAPKinase Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.393E-2 2.065E-2
8.983E-2
5.989E-1
 1 87
30 1404799 Endocrine resistance BioSystems: KEGG 1.536E-2 2.129E-2
9.260E-2
6.606E-1
 1 96
31 799177 Estrogen signaling pathway BioSystems: KEGG 1.568E-2 2.129E-2
9.260E-2
6.743E-1
 1 98
32 1059539 Choline metabolism in cancer BioSystems: KEGG 1.584E-2 2.129E-2
9.260E-2
6.812E-1
 1 99
33 1268743 SUMO E3 ligases SUMOylate target proteins BioSystems: REACTOME 1.664E-2 2.168E-2
9.431E-2
7.154E-1
 1 104
34 1268738 SUMOylation BioSystems: REACTOME 1.759E-2 2.225E-2
9.679E-2
7.565E-1
 1 110
35 1270030 PPARA activates gene expression BioSystems: REACTOME 1.982E-2 2.425E-2
1.055E-1
8.523E-1
 1 124
36 1270029 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) BioSystems: REACTOME 2.030E-2 2.425E-2
1.055E-1
8.728E-1
 1 127
37 137939 Direct p53 effectors BioSystems: Pathway Interaction Database 2.109E-2 2.451E-2
1.066E-1
9.070E-1
 1 132
38 1435207 Breast cancer BioSystems: KEGG 2.300E-2 2.603E-2
1.132E-1
9.890E-1
 1 144
39 523016 Transcriptional misregulation in cancer BioSystems: KEGG 2.871E-2 3.165E-2
1.377E-1
1.000E0
 1 180
40 83100 Huntington's disease BioSystems: KEGG 3.076E-2 3.293E-2
1.432E-1
1.000E0
 1 193
41 1270426 Cellular Senescence BioSystems: REACTOME 3.140E-2 3.293E-2
1.432E-1
1.000E0
 1 197
42 1270010 Fatty acid, triacylglycerol, and ketone body metabolism BioSystems: REACTOME 4.023E-2 4.119E-2
1.792E-1
1.000E0
 1 253
Show 37 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 1745 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 27889927 Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia. Pubmed 5.640E-17 5.477E-14 4.405E-13 9.843E-14 4 4
2 15820306 Mammalian SP/KLF transcription factors: bring in the family. Pubmed 6.278E-17 5.477E-14 4.405E-13 1.095E-13 5 24
3 10547281 Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter. Pubmed 2.820E-16 1.640E-13 1.319E-12 4.921E-13 4 5
4 16201967 Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells. Pubmed 8.460E-16 3.691E-13 2.968E-12 1.476E-12 4 6
5 26967243 Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells. Pubmed 1.077E-12 1.566E-10 1.260E-9 1.879E-9 3 3
6 11532028 Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene. Pubmed 1.077E-12 1.566E-10 1.260E-9 1.879E-9 3 3
7 25793500 Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3. Pubmed 1.077E-12 1.566E-10 1.260E-9 1.879E-9 3 3
8 18593936 Curcumin decreases specificity protein expression in bladder cancer cells. Pubmed 1.077E-12 1.566E-10 1.260E-9 1.879E-9 3 3
9 23540600 Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: a pilot study of relationship to negative symptoms. Pubmed 1.077E-12 1.566E-10 1.260E-9 1.879E-9 3 3
10 26431879 O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities. Pubmed 1.077E-12 1.566E-10 1.260E-9 1.879E-9 3 3
11 21919647 Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. Pubmed 1.077E-12 1.566E-10 1.260E-9 1.879E-9 3 3
12 7559627 Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3. Pubmed 1.077E-12 1.566E-10 1.260E-9 1.879E-9 3 3
13 23463631 Control of Fiat (factor inhibiting ATF4-mediated transcription) expression by Sp family transcription factors in osteoblasts. Pubmed 4.308E-12 5.012E-10 4.030E-9 7.517E-9 3 4
14 15781457 Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx. Pubmed 4.308E-12 5.012E-10 4.030E-9 7.517E-9 3 4
15 15788387 Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases. Pubmed 4.308E-12 5.012E-10 4.030E-9 7.517E-9 3 4
16 12560508 Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors. Pubmed 1.077E-11 1.105E-9 8.890E-9 1.879E-8 3 5
17 20538607 Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. Pubmed 1.077E-11 1.105E-9 8.890E-9 1.879E-8 3 5
18 15987735 Differential intranuclear organization of transcription factors Sp1 and Sp3. Pubmed 2.154E-11 1.978E-9 1.591E-8 3.758E-8 3 6
19 14576192 Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. Pubmed 2.154E-11 1.978E-9 1.591E-8 3.758E-8 3 6
20 12004059 POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1. Pubmed 6.030E-11 5.261E-9 4.231E-8 1.052E-7 3 8
21 1341900 Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
22 9329821 Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
23 21820092 The transcriptional activity of osterix requires the recruitment of Sp1 to the osteocalcin proximal promoter. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
24 22464952 Transcription factors Sp1 and Sp3 regulate basal transcription of the human IRF-3 gene. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
25 18417714 Expression patterns of SP1 and SP3 during mouse spermatogenesis: SP1 down-regulation correlates with two successive promoter changes and translationally compromised transcripts. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
26 21248046 Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
27 26807725 Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
28 9628590 Sp family transcription factors regulate expression of rat D2 dopamine receptor gene. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
29 8845379 Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
30 15816870 Sp1 and Sp3 activate transcription of the human dopamine transporter gene. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
31 14608051 The nuclear abundance of transcription factors Sp1 and Sp3 depends on biotin in Jurkat cells. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
32 25175639 Increased SP4 and SP1 transcription factor expression in the postmortem hippocampus of chronic schizophrenia. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
33 23941741 Reduced expression of SP1 and SP4 transcription factors in peripheral blood mononuclear cells in first-episode psychosis. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
34 1454515 Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
35 19437621 Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
36 25538045 Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
37 10825178 Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
38 18725933 An Sp1/Sp3 binding polymorphism confers methylation protection. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
39 17681019 Transcriptional activity and Sp 1/3 transcription factor binding to the P1 promoter sequences of the human AbetaH-J-J locus. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
40 21604172 Transcriptional control of human CD2AP expression: the role of Sp1 and Sp3. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
41 14766015 Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1. Pubmed 1.371E-8 5.788E-7 4.655E-6 2.393E-5 2 2
42 12730302 Regulation of human CETP gene expression: role of SP1 and SP3 transcription factors at promoter sites -690, -629, and -37. Pubmed 4.113E-8 5.788E-7 4.655E-6 7.177E-5 2 3
43 12664565 Regulation of leukotriene C4 synthase gene expression by SP1 and SP3 in mononuclear phagocytes. Pubmed 4.113E-8 5.788E-7 4.655E-6 7.177E-5 2 3
44 20091743 Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1. Pubmed 4.113E-8 5.788E-7 4.655E-6 7.177E-5 2 3
45 17652716 Laminin reduces expression of the human alpha6 integrin subunit gene by altering the level of the transcription factors Sp1 and Sp3. Pubmed 4.113E-8 5.788E-7 4.655E-6 7.177E-5 2 3
46 16671893 NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes. Pubmed 4.113E-8 5.788E-7 4.655E-6 7.177E-5 2 3
47 15466927 The t-PA -7351C>T enhancer polymorphism decreases Sp1 and Sp3 protein binding affinity and transcriptional responsiveness to retinoic acid. Pubmed 4.113E-8 5.788E-7 4.655E-6 7.177E-5 2 3
48 19064501 Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation. Pubmed 4.113E-8 5.788E-7 4.655E-6 7.177E-5 2 3
49 24324617 Transcriptional activation of Mina by Sp1/3 factors. Pubmed 4.113E-8 5.788E-7 4.655E-6 7.177E-5 2 3
50 12297462 Regulation of telomerase activity in Jurkat T cells by transcription factors Sp1 and Sp3. Pubmed 4.113E-8 5.788E-7 4.655E-6 7.177E-5 2 3
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 296 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:NKX3-1 NKX3-1 interactions 8.060E-11 2.386E-8 1.496E-7 2.386E-8 4 37
2 int:SP4 SP4 interactions 1.663E-8 2.461E-6 1.543E-5 4.923E-6 3 22
3 int:E2F1 E2F1 interactions 3.191E-8 3.148E-6 1.974E-5 9.445E-6 4 160
4 int:ZBTB7A ZBTB7A interactions 9.098E-8 6.732E-6 4.221E-5 2.693E-5 3 38
5 int:SP3 SP3 interactions 1.985E-7 1.175E-5 7.367E-5 5.876E-5 3 49
6 int:CRX CRX interactions 3.684E-7 1.817E-5 1.139E-4 1.090E-4 3 60
7 int:DEAF1 DEAF1 interactions 2.234E-5 9.102E-4 5.706E-3 6.612E-3 2 27
8 int:TNFSF10 TNFSF10 interactions 2.583E-5 9.102E-4 5.706E-3 7.646E-3 2 29
9 int:GABPA GABPA interactions 2.767E-5 9.102E-4 5.706E-3 8.192E-3 2 30
10 int:SP1 SP1 interactions 3.135E-5 9.280E-4 5.818E-3 9.280E-3 3 262
11 int:ZBTB7B ZBTB7B interactions 6.864E-5 1.847E-3 1.158E-2 2.032E-2 2 47
12 int:REST REST interactions 8.744E-5 2.157E-3 1.352E-2 2.588E-2 2 53
13 int:HLTF HLTF interactions 9.769E-5 2.224E-3 1.394E-2 2.891E-2 2 56
14 int:PTPA PTPA interactions 1.443E-4 3.051E-3 1.913E-2 4.271E-2 2 68
15 int:POU2F1 POU2F1 interactions 1.756E-4 3.466E-3 2.173E-2
5.199E-2
 2 75
16 int:SUB1 SUB1 interactions 2.644E-4 4.892E-3 3.067E-2
7.828E-2
 2 92
17 int:CEBPB CEBPB interactions 2.940E-4 5.119E-3 3.209E-2
8.702E-2
 2 97
18 int:TFAP4 TFAP4 interactions 3.711E-4 6.103E-3 3.826E-2
1.099E-1
 2 109
19 int:DNMT1 DNMT1 interactions 3.988E-4 6.213E-3 3.895E-2
1.180E-1
 2 113
20 int:BANP BANP interactions 5.194E-4 7.687E-3 4.819E-2
1.537E-1
 2 129
21 int:TRY2P TRY2P interactions 5.648E-4 7.961E-3 4.991E-2
1.672E-1
 1 2
22 int:YY1 YY1 interactions 6.646E-4 8.942E-3
5.606E-2
1.967E-1
 2 146
23 int:MECP2 MECP2 interactions 8.073E-4 1.039E-2
6.514E-2
2.390E-1
 2 161
24 int:TBP TBP interactions 1.075E-3 1.326E-2
8.315E-2
3.183E-1
 2 186
25 int:ATF7IP2 ATF7IP2 interactions 1.412E-3 1.607E-2
1.007E-1
4.178E-1
 1 5
26 int:KLF9 KLF9 interactions 1.412E-3 1.607E-2
1.007E-1
4.178E-1
 1 5
27 int:SIN3A SIN3A interactions 1.666E-3 1.791E-2
1.123E-1
4.932E-1
 2 232
28 int:RBBP4 RBBP4 interactions 1.695E-3 1.791E-2
1.123E-1
5.016E-1
 2 234
29 int:RB1 RB1 interactions 2.199E-3 2.156E-2
1.352E-1
6.510E-1
 2 267
30 int:DLX4 DLX4 interactions 2.258E-3 2.156E-2
1.352E-1
6.683E-1
 1 8
31 int:PHOX2A PHOX2A interactions 2.258E-3 2.156E-2
1.352E-1
6.683E-1
 1 8
32 int:ATXN7L1 ATXN7L1 interactions 2.540E-3 2.278E-2
1.428E-1
7.517E-1
 1 9
33 int:CNTLN CNTLN interactions 2.540E-3 2.278E-2
1.428E-1
7.517E-1
 1 9
34 int:SFPQ SFPQ interactions 2.659E-3 2.315E-2
1.451E-1
7.871E-1
 2 294
35 int:STK19 STK19 interactions 2.822E-3 2.320E-2
1.454E-1
8.352E-1
 1 10
36 int:SRY SRY interactions 2.822E-3 2.320E-2
1.454E-1
8.352E-1
 1 10
37 int:SP7 SP7 interactions 3.103E-3 2.339E-2
1.466E-1
9.186E-1
 1 11
38 int:DLX1 DLX1 interactions 3.385E-3 2.339E-2
1.466E-1
1.000E0
 1 12
39 int:B4GALT4 B4GALT4 interactions 3.385E-3 2.339E-2
1.466E-1
1.000E0
 1 12
40 int:ADAMTS12 ADAMTS12 interactions 3.385E-3 2.339E-2
1.466E-1
1.000E0
 1 12
41 int:MYL3 MYL3 interactions 3.385E-3 2.339E-2
1.466E-1
1.000E0
 1 12
42 int:CLCN1 CLCN1 interactions 3.385E-3 2.339E-2
1.466E-1
1.000E0
 1 12
43 int:GSK3B GSK3B interactions 3.398E-3 2.339E-2
1.466E-1
1.000E0
 2 333
44 int:CTCFL CTCFL interactions 3.667E-3 2.467E-2
1.546E-1
1.000E0
 1 13
45 int:ELF1 ELF1 interactions 3.948E-3 2.548E-2
1.597E-1
1.000E0
 1 14
46 int:RELA RELA interactions 4.047E-3 2.548E-2
1.597E-1
1.000E0
 2 364
47 int:HOXC11 HOXC11 interactions 4.230E-3 2.548E-2
1.597E-1
1.000E0
 1 15
48 int:SGCZ SGCZ interactions 4.230E-3 2.548E-2
1.597E-1
1.000E0
 1 15
49 int:ITLN1 ITLN1 interactions 4.230E-3 2.548E-2
1.597E-1
1.000E0
 1 15
50 int:HDAC2 HDAC2 interactions 4.357E-3 2.548E-2
1.597E-1
1.000E0
 2 378
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12q13.1 12q13.1 1.874E-3 4.685E-3 1.070E-2 9.370E-3 1 13
2 2q31 2q31 1.874E-3 4.685E-3 1.070E-2 9.370E-3 1 13
3 7p15.3 7p15.3 4.320E-3 7.201E-3 1.644E-2 2.160E-2 1 30
4 17q21.32 17q21.32 7.049E-3 8.811E-3 2.012E-2 3.524E-2 1 49
5 12q13.13 12q13.13 1.006E-2 1.006E-2 2.297E-2
5.029E-2
 1 70

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 91 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$RREB1 01 V$RREB1 01 5.225E-5 3.843E-3 1.957E-2 4.755E-3 3 172
2 V$SPZ1 01 V$SPZ1 01 8.446E-5 3.843E-3 1.957E-2 7.686E-3 3 202
3 V$GATA2 01 V$GATA2 01 8.061E-4 2.445E-2
1.245E-1
7.335E-2
 2 89
4 V$AP2ALPHA 01 V$AP2ALPHA 01 3.809E-3 4.780E-2
2.435E-1
3.466E-1
 2 195
5 V$TCF1P Q6 V$TCF1P Q6 3.848E-3 4.780E-2
2.435E-1
3.501E-1
 2 196
6 V$GATA1 01 V$GATA1 01 3.886E-3 4.780E-2
2.435E-1
3.537E-1
 2 197
7 V$AP2 Q6 V$AP2 Q6 4.043E-3 4.780E-2
2.435E-1
3.679E-1
 2 201
8 V$ALPHACP1 01 V$ALPHACP1 01 4.202E-3 4.780E-2
2.435E-1
3.824E-1
 2 205
9 V$EGR Q6 V$EGR Q6 4.956E-3 4.956E-2
2.524E-1
4.510E-1
 2 223
10 GTGGGTGK UNKNOWN GTGGGTGK UNKNOWN 5.446E-3 4.956E-2
2.524E-1
4.956E-1
 2 234
Show 5 more annotations

12: Gene Family [Display Chart] 5 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 755 Zinc fingers C2H2-type|Sp transcription factors genenames.org 7.588E-18 7.588E-18 7.588E-18 7.588E-18 5 9

13: Coexpression [Display Chart] 5 input genes in category / 333 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M9362 Cluster 4: genes down-regulated in lung tissue samples from mice with tumor-bearing genotypes (activated KRAS [GeneID=3845] alone or together with inactivated PTEN [GeneID=5728]). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.641E-4 1.738E-2
1.110E-1
8.793E-2
 2 120
2 M7116 Genes up-regulated in CD4 [GeneID=920] T cells: control versus treated with halofuginone [PubChem=400772] for 3h. MSigDB C7: Immunologic Signatures (v6.0) 4.457E-4 1.738E-2
1.110E-1
1.484E-1
 2 156
3 M6593 Genes down-regulated upon CSF1 [GeneID=1435] treatment: monocytes (3 days) versus macrophages (7 days). MSigDB C7: Immunologic Signatures (v6.0) 6.739E-4 1.738E-2
1.110E-1
2.244E-1
 2 192
4 M6227 Genes up-regulated in thymocytes: double positive versus CD4 [GeneID=920] single positive. MSigDB C7: Immunologic Signatures (v6.0) 6.739E-4 1.738E-2
1.110E-1
2.244E-1
 2 192
5 M2861 Genes down-regulated in epithelial lung cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 6.879E-4 1.738E-2
1.110E-1
2.291E-1
 2 194
6 M6234 Genes up-regulated in double negative thymocyte versus immature CD4 [GeneID=920] single positive cells. MSigDB C7: Immunologic Signatures (v6.0) 6.879E-4 1.738E-2
1.110E-1
2.291E-1
 2 194
7 M6237 Genes down-regulated in CD4 [GeneID=920] single positive cells: immature versus thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 6.950E-4 1.738E-2
1.110E-1
2.314E-1
 2 195
8 M6217 Genes up-regulated in polymorphonuclear leukocytes (9h): control versus infection by A. phagocytophilum. MSigDB C7: Immunologic Signatures (v6.0) 6.950E-4 1.738E-2
1.110E-1
2.314E-1
 2 195
9 M2817 Genes up-regulated in prefrontal cortex (PFC) of mice carrying a hemizygotic microdeletion in the 22q11.2 region. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.950E-4 1.738E-2
1.110E-1
2.314E-1
 2 195
10 M9836 Genes up-regulated in at day 0 B cell IRF4-KO versus CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell IRF4intermediate. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.738E-2
1.110E-1
2.434E-1
 2 200
11 M3399 Genes down-regulated in comparison of induced regulatory T cell (Treg) versus natural regulatory T cell (Treg). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.738E-2
1.110E-1
2.434E-1
 2 200
12 M8261 Genes down-regulated in B lymphocytes: wildtype versus NFATC1 [GeneID=4772] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.738E-2
1.110E-1
2.434E-1
 2 200
13 M7075 Genes down-regulated in CD4 [GeneID=920] T cells from atopic patients: resting versus stimulated with allergen (house dust mite). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.738E-2
1.110E-1
2.434E-1
 2 200
14 M9045 Genes up-regulated in T reg: untreated versus ZM 241385 [PubChem=176407]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.738E-2
1.110E-1
2.434E-1
 2 200
15 17676974-TableS4 Mouse StemCell Chambers07 411genes GeneSigDB 1.890E-3 4.195E-2
2.679E-1
6.292E-1
 2 323
16 M15804 Examples of transcription factors whose activities are regulated by MAPK1 and MAPK3 [GeneID=5594;5595] phosphorylation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.591E-3 4.669E-2
2.982E-1
8.627E-1
 1 12
17 M6267 An assortment of osteoblast transcriptional regulators. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.022E-3 4.669E-2
2.982E-1
1.000E0
 1 14
18 18927307-table2 Human Colon Allen08 16genes GeneSigDB 3.022E-3 4.669E-2
2.982E-1
1.000E0
 1 14
19 M1562 Genes in cluster 2: moderately up-regulated in HFW cells (fibroblast) upon treatment with sodium arsenite [PubChem=26435] at all time points. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.884E-3 4.669E-2
2.982E-1
1.000E0
 1 18
20 16397240-Table1b Human Colon Grade06 19genes GeneSigDB 4.100E-3 4.669E-2
2.982E-1
1.000E0
 1 19
21 M4495 Substrates of PRKDC [GeneID=5591]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.315E-3 4.669E-2
2.982E-1
1.000E0
 1 20
22 15041723-Table2 Human Thyroid Yano04 27genes GeneSigDB 4.961E-3 4.669E-2
2.982E-1
1.000E0
 1 23
23 20081105-Table4 Human Breast Nagaraja10 25genes mir-182Knockdown GeneSigDB 5.176E-3 4.669E-2
2.982E-1
1.000E0
 1 24
24 M16374 Genes down-regulated during transition from G1 (well differentiated tumor, infected with HCV) to G2 (moderately differentiated tumor, infected with HCV) in the development of hepatocellular carcinoma. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.391E-3 4.669E-2
2.982E-1
1.000E0
 1 25
25 17284527-Table3 Human Lypmhoma Leval07 28genes GeneSigDB 5.607E-3 4.669E-2
2.982E-1
1.000E0
 1 26
26 18977325-Figure5f Human Leukemia Krivtsov08 36genes GeneSigDB 7.112E-3 4.669E-2
2.982E-1
1.000E0
 1 33
27 M1545 Genes up-regulated in MMEC cells (myometrial endothelium) at 12 h after VEGFA [GeneID=7422] stimulation. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.541E-3 4.669E-2
2.982E-1
1.000E0
 1 35
28 18812457-Table2 Mouse Viral Mercader08 51genes GeneSigDB 7.541E-3 4.669E-2
2.982E-1
1.000E0
 1 35
29 M972 Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of methyl methanesulfonate (MMS) MSigDB C2: CGP Curated Gene Sets (v6.0) 7.756E-3 4.669E-2
2.982E-1
1.000E0
 1 36
30 M1558 Strongly down-regulated at 2 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.756E-3 4.669E-2
2.982E-1
1.000E0
 1 36
31 M11048 Selected gradually up-regulated genes whose expression profile follows that of CCNE1 [GeneID=898] in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts). MSigDB C2: CGP Curated Gene Sets (v6.0) 8.615E-3 4.669E-2
2.982E-1
1.000E0
 1 40
32 M4519 Neurologically relevant transcripts with highest abundance fold range in brain tissue among mouse strains. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.615E-3 4.669E-2
2.982E-1
1.000E0
 1 40
33 19922785-Table3 Human Leukemia Yang09 42genes GeneSigDB 8.830E-3 4.669E-2
2.982E-1
1.000E0
 1 41
34 19965622-TableS2b Human LymphaticEndothelialCells Norrmen09 65genes GeneSigDB 1.183E-2 4.669E-2
2.982E-1
1.000E0
 1 55
35 M1521 Genes up-regulated in MMEC cells (myometrial endothelium) at 6 h after VEGFA [GeneID=7422] stimulation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.269E-2 4.669E-2
2.982E-1
1.000E0
 1 59
36 M7899 Oxidative stress genes down-regulated in ARPE-19 cells (retinal pigmented epithelium) in response to HNE and tBH [PubChem=5283344;6410]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.290E-2 4.669E-2
2.982E-1
1.000E0
 1 60
37 M10880 Down-regulated genes classifying non-tumor lung tissues by age after incution of lung cancer by urethane injection [PubChem=5641]: early (24-26 weeks) vs late (46 weeks). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.311E-2 4.669E-2
2.982E-1
1.000E0
 1 61
38 17170073-TableS3 Mouse StemCell zurNieden07 81genes GeneSigDB 1.504E-2 4.669E-2
2.982E-1
1.000E0
 1 70
39 M1965 Genes with low-CpG-density promoters (LCP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MEF cells (embryonic fibroblasts). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.504E-2 4.669E-2
2.982E-1
1.000E0
 1 70
40 M1673 Genes up-regulated in MMEC cells (myometrial endothelium) at 3 h after VEGFA [GeneID=7422] stimulation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.589E-2 4.669E-2
2.982E-1
1.000E0
 1 74
41 M13387 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 6. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.610E-2 4.669E-2
2.982E-1
1.000E0
 1 75
42 M5827 Genes up-regulated in non-metastatic breast cancer tumors having type 1 amplification in the 20q13 region; involves ZNF217 [GeneID=7764] locus only. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.653E-2 4.669E-2
2.982E-1
1.000E0
 1 77
43 M16458 Selected gradually up-regulated genes in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.653E-2 4.669E-2
2.982E-1
1.000E0
 1 77
44 18927307-tableS4 Human Colon Allen08 124genes GeneSigDB 1.674E-2 4.669E-2
2.982E-1
1.000E0
 1 78
45 11325847-Table2 Human Endometrial Matsushima-Nishiu01 97genes GeneSigDB 1.674E-2 4.669E-2
2.982E-1
1.000E0
 1 78
46 18691415-Table5d Human Colon Solmi08 94genes GbTreatment GeneSigDB 1.674E-2 4.669E-2
2.982E-1
1.000E0
 1 78
47 15897889-Table4 Human Skin Kyng05 81genes GeneSigDB 1.696E-2 4.669E-2
2.982E-1
1.000E0
 1 79
48 M12971 Genes specifically responding to gamma radiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.738E-2 4.669E-2
2.982E-1
1.000E0
 1 81
49 M1436 Genes up-regulated in day 6 embryoid bodies derived from embryonic stem cells (ES) with HEX [GeneID=3087] knockout. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.738E-2 4.669E-2
2.982E-1
1.000E0
 1 81
50 19965622-TableS1b Human LymphaticEndothelialCells Norrmen09 99genes GeneSigDB 1.887E-2 4.669E-2
2.982E-1
1.000E0
 1 88
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 178 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingGonad e12.5 epididymis 500 DevelopingGonad e12.5 epididymis emap-29139 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.076E-5 1.082E-2
6.232E-2
 1.082E-2 3 403
2 gudmap developingGonad P2 epididymis 1000 k4 DevelopingGonad P2 epididymis emap-30199 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.705E-4 1.517E-2
8.743E-2
 3.035E-2 2 91
3 gudmap developingGonad e18.5 epididymis 200 DevelopingGonad e18.5 epididymis emap-13166 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.662E-4 2.550E-2
1.469E-1
1.008E-1
 2 166
4 gudmap developingGonad e14.5 epididymis 200 DevelopingGonad e14.5 epididymis emap-29141 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.731E-4 2.550E-2
1.469E-1
1.020E-1
 2 167
5 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 250 M-vs-F-2X DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 M-2fold-vs-F top305 305 Gudmap Mouse MOE430.2 1.444E-3 4.297E-2
2.476E-1
2.570E-1
 2 266
6 gudmap developingGonad e14.5 ovary 500 DevelopingGonad e14.5 ovary emap-6699 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.965E-3 4.297E-2
2.476E-1
5.277E-1
 2 383
7 gudmap developingGonad e18.5 ovary 500 DevelopingGonad e18.5 ovary emap-12283 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.041E-3 4.297E-2
2.476E-1
5.414E-1
 2 388
8 gudmap developingGonad e16.5 ovary 500 DevelopingGonad e16.5 ovary emap-9563 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.057E-3 4.297E-2
2.476E-1
5.441E-1
 2 389
9 gudmap developingGonad P2 epididymis 500 DevelopingGonad P2 epididymis emap-30199 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.150E-3 4.297E-2
2.476E-1
5.607E-1
 2 395
10 gudmap developingGonad e18.5 epididymis 500 DevelopingGonad e18.5 epididymis emap-13166 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.309E-3 4.297E-2
2.476E-1
5.890E-1
 2 405
11 gudmap developingGonad e16.5 epididymis 500 DevelopingGonad e16.5 epididymis emap-29702 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.341E-3 4.297E-2
2.476E-1
5.947E-1
 2 407
12 gudmap developingGonad e12.5 ovary 500 DevelopingGonad e12.5 ovary emap-28876 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.373E-3 4.297E-2
2.476E-1
6.005E-1
 2 409
13 gudmap developingGonad e14.5 epididymis 500 DevelopingGonad e14.5 epididymis emap-29141 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.438E-3 4.297E-2
2.476E-1
6.120E-1
 2 413
14 gudmap developingGonad e11.5 ovary + mesonephros 500 DevelopingGonad e11.5 ovary + mesonephros emap-3226 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.504E-3 4.297E-2
2.476E-1
6.237E-1
 2 417
15 gudmap developingGonad e14.5 epididymis 200 k1 DevelopingGonad e14.5 epididymis emap-29141 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.345E-3 4.297E-2
2.476E-1
7.734E-1
 1 19
16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-E/Kidney Tumour Wilms EN-E/Kidney Tumour Wilms EN18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-E/Kidney Tumour Wilms EN-E/Kidney Tumour Wilms EN18 Adult, Development, and Cancer types 4.345E-3 4.297E-2
2.476E-1
7.734E-1
 1 19
17 gudmap developingGonad e16.5 epididymis 200 k2 DevelopingGonad e16.5 epididymis emap-29702 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.345E-3 4.297E-2
2.476E-1
7.734E-1
 1 19
18 gudmap developingGonad e18.5 epididymis 200 k1 DevelopingGonad e18.5 epididymis emap-13166 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.345E-3 4.297E-2
2.476E-1
7.734E-1
 1 19
19 gudmap developingGonad e14.5 epididymis 200 k2 DevelopingGonad e14.5 epididymis emap-29141 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.801E-3 4.498E-2
2.592E-1
8.546E-1
 1 21
20 gudmap developingGonad e18.5 epididymis 200 k2 DevelopingGonad e18.5 epididymis emap-13166 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.258E-3 4.679E-2
2.696E-1
9.359E-1
 1 23
21 gudmap developingGonad e11.5 ovary + mesonephros k3 100 DevelopingGonad e11.5 ovary + mesonephros emap-3226 k-means-cluster#3 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 5.714E-3 4.807E-2
2.770E-1
1.000E0
 1 25
22 gudmap developingGonad e12.5 ovary k1 100 DevelopingGonad e12.5 ovary emap-28876 k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 5.942E-3 4.807E-2
2.770E-1
1.000E0
 1 26
Show 17 more annotations

15: Computational [Display Chart] 4 input genes in category / 25 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 5 input genes in category / 478 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TATTATA,MIR-374:MSigDB TATTATA,MIR-374:MSigDB MSigDB 4.909E-7 9.750E-5 6.579E-4 2.347E-4 3 266
2 hsa-miR-935:PITA hsa-miR-935:PITA TOP PITA 5.851E-7 9.750E-5 6.579E-4 2.797E-4 3 282
3 CACTGTG,MIR-128A:MSigDB CACTGTG,MIR-128A:MSigDB MSigDB 8.159E-7 9.750E-5 6.579E-4 3.900E-4 3 315
4 CACTGTG,MIR-128B:MSigDB CACTGTG,MIR-128B:MSigDB MSigDB 8.159E-7 9.750E-5 6.579E-4 3.900E-4 3 315
5 CTTTGTA,MIR-524:MSigDB CTTTGTA,MIR-524:MSigDB MSigDB 1.786E-6 1.447E-4 9.766E-4 8.539E-4 3 409
6 hsa-miR-27a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.061E-6 1.447E-4 9.766E-4 9.853E-4 3 429
7 hsa-miR-105:PITA hsa-miR-105:PITA TOP PITA 2.119E-6 1.447E-4 9.766E-4 1.013E-3 3 433
8 GTATGAT,MIR-154:MSigDB GTATGAT,MIR-154:MSigDB MSigDB 7.472E-6 3.968E-4 2.678E-3 3.572E-3 2 63
9 GTATGAT,MIR-487:MSigDB GTATGAT,MIR-487:MSigDB MSigDB 7.472E-6 3.968E-4 2.678E-3 3.572E-3 2 63
10 hsa-miR-450b-3p:PITA hsa-miR-450b-3p:PITA TOP PITA 1.365E-5 6.073E-4 4.098E-3 6.525E-3 2 85
11 hsa-miR-769-3p:PITA hsa-miR-769-3p:PITA TOP PITA 1.397E-5 6.073E-4 4.098E-3 6.680E-3 2 86
12 GTTATAT,MIR-410:MSigDB GTTATAT,MIR-410:MSigDB MSigDB 1.531E-5 6.099E-4 4.116E-3 7.319E-3 2 90
13 hsa-miR-223-3p:Functional MTI Functional MTI miRTarbase 1.817E-5 6.459E-4 4.359E-3 8.684E-3 2 98
14 hsa-miR-411:PITA hsa-miR-411:PITA TOP PITA 1.892E-5 6.459E-4 4.359E-3 9.043E-3 2 100
15 hsa-miR-1291:PITA hsa-miR-1291:PITA TOP PITA 3.252E-5 9.446E-4 6.374E-3 1.554E-2 2 131
16 TGTATGA,MIR-485-3P:MSigDB TGTATGA,MIR-485-3P:MSigDB MSigDB 3.454E-5 9.446E-4 6.374E-3 1.651E-2 2 135
17 hsa-miR-597:PITA hsa-miR-597:PITA TOP PITA 3.454E-5 9.446E-4 6.374E-3 1.651E-2 2 135
18 hsa-miR-637:PITA hsa-miR-637:PITA TOP PITA 3.557E-5 9.446E-4 6.374E-3 1.700E-2 2 137
19 hsa-miR-330-3p:Functional MTI Functional MTI miRTarbase 4.040E-5 1.016E-3 6.859E-3 1.931E-2 2 146
20 hsa-miR-766:PITA hsa-miR-766:PITA TOP PITA 4.496E-5 1.075E-3 7.251E-3 2.149E-2 2 154
21 GCATTTG,MIR-105:MSigDB GCATTTG,MIR-105:MSigDB MSigDB 5.037E-5 1.108E-3 7.476E-3 2.408E-2 2 163
22 hsa-miR-486-3p:PITA hsa-miR-486-3p:PITA TOP PITA 5.099E-5 1.108E-3 7.476E-3 2.438E-2 2 164
23 GCAAAAA,MIR-129:MSigDB GCAAAAA,MIR-129:MSigDB MSigDB 5.741E-5 1.193E-3 8.051E-3 2.744E-2 2 174
24 hsa-miR-337-3p:PITA hsa-miR-337-3p:PITA TOP PITA 7.063E-5 1.393E-3 9.398E-3 3.376E-2 2 193
25 hsa-miR-592:PITA hsa-miR-592:PITA TOP PITA 7.284E-5 1.393E-3 9.398E-3 3.482E-2 2 196
26 hsa-miR-31-5p:Functional MTI Functional MTI miRTarbase 9.513E-5 1.749E-3 1.180E-2 4.547E-2 2 224
27 hsa-miR-223:PITA hsa-miR-223:PITA TOP PITA 1.012E-4 1.770E-3 1.194E-2 4.836E-2 2 231
28 GTTTGTT,MIR-495:MSigDB GTTTGTT,MIR-495:MSigDB MSigDB 1.056E-4 1.770E-3 1.194E-2
5.047E-2
 2 236
29 hsa-miR-145-5p:Functional MTI Functional MTI miRTarbase 1.074E-4 1.770E-3 1.194E-2
5.133E-2
 2 238
30 hsa-miR-487a:PITA hsa-miR-487a:PITA TOP PITA 1.138E-4 1.813E-3 1.223E-2
5.439E-2
 2 245
31 ATTCTTT,MIR-186:MSigDB ATTCTTT,MIR-186:MSigDB MSigDB 1.213E-4 1.842E-3 1.243E-2
5.799E-2
 2 253
32 hsa-miR-199b-5p:PITA hsa-miR-199b-5p:PITA TOP PITA 1.271E-4 1.842E-3 1.243E-2
6.077E-2
 2 259
33 hsa-miR-199a-5p:PITA hsa-miR-199a-5p:PITA TOP PITA 1.271E-4 1.842E-3 1.243E-2
6.077E-2
 2 259
34 hsa-miR-634:PITA hsa-miR-634:PITA TOP PITA 1.402E-4 1.971E-3 1.330E-2
6.701E-2
 2 272
35 ATGTACA,MIR-493:MSigDB ATGTACA,MIR-493:MSigDB MSigDB 1.637E-4 2.115E-3 1.427E-2
7.826E-2
 2 294
36 hsa-miR-557:PITA hsa-miR-557:PITA TOP PITA 1.750E-4 2.115E-3 1.427E-2
8.367E-2
 2 304
37 hsa-miR-507:PITA hsa-miR-507:PITA TOP PITA 1.750E-4 2.115E-3 1.427E-2
8.367E-2
 2 304
38 hsa-miR-155:PITA hsa-miR-155:PITA TOP PITA 1.750E-4 2.115E-3 1.427E-2
8.367E-2
 2 304
39 hsa-miR-454*:mirSVR highEffct hsa-miR-454*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.808E-4 2.115E-3 1.427E-2
8.643E-2
 2 309
40 TTTGTAG,MIR-520D:MSigDB TTTGTAG,MIR-520D:MSigDB MSigDB 1.820E-4 2.115E-3 1.427E-2
8.699E-2
 2 310
41 AAGCCAT,MIR-135B:MSigDB AAGCCAT,MIR-135B:MSigDB MSigDB 1.879E-4 2.115E-3 1.427E-2
8.981E-2
 2 315
42 AAGCCAT,MIR-135A:MSigDB AAGCCAT,MIR-135A:MSigDB MSigDB 1.879E-4 2.115E-3 1.427E-2
8.981E-2
 2 315
43 hsa-miR-515-5p:PITA hsa-miR-515-5p:PITA TOP PITA 1.903E-4 2.115E-3 1.427E-2
9.095E-2
 2 317
44 hsa-miR-140-3p:PITA hsa-miR-140-3p:PITA TOP PITA 2.049E-4 2.226E-3 1.502E-2
9.795E-2
 2 329
45 hsa-miR-768-3p:PITA hsa-miR-768-3p:PITA TOP PITA 2.438E-4 2.549E-3 1.720E-2
1.166E-1
 2 359
46 hsa-miR-216a:PITA hsa-miR-216a:PITA TOP PITA 2.493E-4 2.549E-3 1.720E-2
1.192E-1
 2 363
47 hsa-miR-410:PITA hsa-miR-410:PITA TOP PITA 2.507E-4 2.549E-3 1.720E-2
1.198E-1
 2 364
48 hsa-miR-603:PITA hsa-miR-603:PITA TOP PITA 2.803E-4 2.791E-3 1.884E-2
1.340E-1
 2 385
49 hsa-miR-4668-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.055E-4 2.980E-3 2.011E-2
1.460E-1
 2 402
50 hsa-miR-485-3p:PITA hsa-miR-485-3p:PITA TOP PITA 3.365E-4 3.217E-3 2.171E-2
1.608E-1
 2 422
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 1456 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID002742752 SP 0 Stitch 9.259E-14 1.348E-10 1.060E-9 1.348E-10 4 10
2 CID000126311 ADP-ribosylarginine Stitch 5.574E-12 4.058E-9 3.190E-8 8.116E-9 4 25
3 CID000169313 3-(2-carboxyindol-3-yl)propionic acid Stitch 5.435E-11 2.638E-8 2.074E-7 7.913E-8 4 43
4 CID000001263 AC1L1B35 Stitch 5.062E-10 1.842E-7 1.448E-6 7.370E-7 4 74
5 CID000036511 Substance P Stitch 7.419E-10 2.161E-7 1.698E-6 1.080E-6 5 343
6 ctd:C021304 hyperoside CTD 1.157E-8 2.807E-6 2.206E-5 1.684E-5 3 25
7 CID000045749 C15873 Stitch 1.471E-8 3.059E-6 2.405E-5 2.141E-5 3 27
8 CID000006242 Eledoisinum Stitch 3.007E-8 5.321E-6 4.183E-5 4.379E-5 3 34
9 CID000017268 Physalemin Stitch 3.289E-8 5.321E-6 4.183E-5 4.789E-5 3 35
10 CID000556031 2-pyridinecarboxaldehyde N-oxide Stitch 3.834E-8 5.582E-6 4.388E-5 5.582E-5 2 2
11 ctd:C007956 homocysteic acid CTD 1.150E-7 1.288E-5 1.013E-4 1.674E-4 2 3
12 CID003083813 AC1MJ1BZ Stitch 1.150E-7 1.288E-5 1.013E-4 1.674E-4 2 3
13 CID000189012 6-hydroxyuridine Stitch 1.150E-7 1.288E-5 1.013E-4 1.674E-4 2 3
14 CID004110181 AC1N3C6T Stitch 2.300E-7 2.392E-5 1.880E-4 3.349E-4 2 4
15 CID000355017 from Dendrobium nobile Stitch 3.833E-7 3.488E-5 2.742E-4 5.580E-4 2 5
16 CID000032794 poly(tetramethylene adipate Stitch 3.833E-7 3.488E-5 2.742E-4 5.580E-4 2 5
17 CID000012514 2,5-dimethylthiophene Stitch 5.749E-7 4.650E-5 3.655E-4 8.370E-4 2 6
18 CID000001095 shikimic acid-3-phosphate Stitch 5.749E-7 4.650E-5 3.655E-4 8.370E-4 2 6
19 CID011378474 isobenzofuran Stitch 8.047E-7 5.610E-5 4.410E-4 1.172E-3 2 7
20 CID005462117 6-fluoranyl-7H-purine Stitch 8.047E-7 5.610E-5 4.410E-4 1.172E-3 2 7
21 CID000005519 TPEN Stitch 8.091E-7 5.610E-5 4.410E-4 1.178E-3 3 100
22 CID005460457 germyl Stitch 1.073E-6 6.509E-5 5.117E-4 1.562E-3 2 8
23 CID000136334 diazinane Stitch 1.073E-6 6.509E-5 5.117E-4 1.562E-3 2 8
24 CID000015664 5,5'-dimethyl-2,2'-bipyridine Stitch 1.073E-6 6.509E-5 5.117E-4 1.562E-3 2 8
25 CID000029051 NSC24559 Stitch 1.475E-6 8.591E-5 6.754E-4 2.148E-3 3 122
26 CID000007228 D-IBS Stitch 1.724E-6 9.654E-5 7.589E-4 2.510E-3 2 10
27 ctd:C492909 1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane CTD 2.107E-6 1.136E-4 8.931E-4 3.068E-3 2 11
28 CID000066227 boron nitride Stitch 2.528E-6 1.269E-4 9.978E-4 3.681E-3 2 12
29 CID000517869 AC1LAPJB Stitch 2.528E-6 1.269E-4 9.978E-4 3.681E-3 2 12
30 CID006917838 NSC-350602 Stitch 2.987E-6 1.450E-4 1.140E-3 4.350E-3 2 13
31 CID005311244 AC1NSKAN Stitch 3.485E-6 1.637E-4 1.287E-3 5.074E-3 2 14
32 ctd:C576677 demycarosyl-3D-digitoxosylmithramycin SK CTD 4.595E-6 2.091E-4 1.643E-3 6.690E-3 2 16
33 CID000123994 Dimethyl C7 Stitch 5.857E-6 2.584E-4 2.032E-3 8.528E-3 2 18
34 CID000007408 alpha-methylbenzylamine Stitch 6.546E-6 2.803E-4 2.204E-3 9.531E-3 2 19
35 CID000447015 AC1L9KDA Stitch 7.273E-6 3.025E-4 2.378E-3 1.059E-2 2 20
36 CID000010614 triphenylmethane Stitch 8.037E-6 3.163E-4 2.486E-3 1.170E-2 2 21
37 CID000151434 Db04047 Stitch 8.037E-6 3.163E-4 2.486E-3 1.170E-2 2 21
38 CID000447936 3,9-dimethyladenine Stitch 9.681E-6 3.710E-4 2.916E-3 1.410E-2 2 23
39 CID000006326 vinylene Stitch 1.200E-5 4.415E-4 3.471E-3 1.747E-2 3 245
40 CID004369569 AC1NA0BL Stitch 1.243E-5 4.415E-4 3.471E-3 1.810E-2 2 26
41 CID000449488 imidazolidine Stitch 1.243E-5 4.415E-4 3.471E-3 1.810E-2 2 26
42 CID006326954 germanium Stitch 1.343E-5 4.655E-4 3.659E-3 1.955E-2 2 27
43 CID000001010 NSC292228 Stitch 1.664E-5 5.633E-4 4.428E-3 2.422E-2 2 30
44 ctd:C066851 mithramycin A CTD 1.778E-5 5.884E-4 4.625E-3 2.589E-2 2 31
45 CID000007422 3-NT Stitch 1.897E-5 6.003E-4 4.719E-3 2.761E-2 2 32
46 CID000000153 AC1Q6RZK Stitch 1.897E-5 6.003E-4 4.719E-3 2.761E-2 2 32
47 ctd:D026422 S-Nitrosoglutathione CTD 2.145E-5 6.506E-4 5.114E-3 3.123E-2 2 34
48 CID000000711 FMNH2 Stitch 2.145E-5 6.506E-4 5.114E-3 3.123E-2 2 34
49 CID000139283 diphosphine Stitch 2.832E-5 8.414E-4 6.614E-3 4.123E-2 2 39
50 CID000123164 methyl-ene Stitch 3.133E-5 8.708E-4 6.845E-3 4.562E-2 2 41
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 79 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0349204 Nonorganic psychosis DisGeNET Curated 2.452E-5 1.759E-3 8.711E-3 1.937E-3 3 221
2 C0280220 stage, ovarian epithelial cancer DisGeNET BeFree 5.618E-5 1.759E-3 8.711E-3 4.438E-3 2 39
3 C0033975 Psychotic Disorders DisGeNET Curated 6.804E-5 1.759E-3 8.711E-3 5.375E-3 3 311
4 C0221765 Chronic schizophrenia DisGeNET Curated 8.905E-5 1.759E-3 8.711E-3 7.035E-3 2 49
5 cv:C3151218 Osteogenesis imperfecta type 11 Clinical Variations 3.085E-4 4.875E-3 2.415E-2 2.438E-2 1 1
6 C0862824 Stage I Lung Cancer DisGeNET BeFree 2.466E-3 3.097E-2
1.534E-1
1.948E-1
 1 8
7 C4022560 Splanchnic vein thrombosis DisGeNET BeFree 3.082E-3 3.097E-2
1.534E-1
2.435E-1
 1 10
8 C0268363 Osteogenesis imperfecta type IV (disorder) DisGeNET Curated 3.698E-3 3.097E-2
1.534E-1
2.921E-1
 1 12
9 C1840333 Barakat syndrome DisGeNET Curated 3.698E-3 3.097E-2
1.534E-1
2.921E-1
 1 12
10 C0276096 Mastitis-metritis-agalactia syndrome DisGeNET BeFree 4.313E-3 3.097E-2
1.534E-1
3.407E-1
 1 14
11 C0042025 Urinary Stress Incontinence DisGeNET BeFree 4.313E-3 3.097E-2
1.534E-1
3.407E-1
 1 14
12 C0854988 Adenocarcinoma of lung, stage IV DisGeNET BeFree 5.235E-3 3.363E-2
1.665E-1
4.136E-1
 1 17
13 C0035412 Rhabdomyosarcoma DisGeNET Curated 5.533E-3 3.363E-2
1.665E-1
4.371E-1
 2 391
14 C0936250 Eczema Herpeticum DisGeNET BeFree 6.156E-3 3.474E-2
1.721E-1
4.864E-1
 1 20
Show 9 more annotations