1: GO: Molecular Function [Display Chart]
10 input genes in category / 31 annotations before applied cutoff / 18661 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
GO:0070888
|
E-box binding
|
|
2.160E-9
|
6.695E-8
|
2.696E-7
|
6.695E-8
|
4
|
35
|
|
2
|
GO:0035939
|
microsatellite binding
|
|
7.752E-7
|
1.202E-5
|
4.839E-5
|
2.403E-5
|
2
|
3
|
|
3
|
GO:0003696
|
satellite DNA binding
|
|
5.420E-6
|
5.601E-5
|
2.256E-4
|
1.680E-4
|
2
|
7
|
|
4
|
GO:0000983
|
transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding
|
|
2.344E-5
|
1.237E-4
|
4.982E-4
|
7.266E-4
|
2
|
14
|
|
5
|
GO:0001228
|
DNA-binding transcription activator activity, RNA polymerase II-specific
|
|
2.525E-5
|
1.237E-4
|
4.982E-4
|
7.828E-4
|
4
|
357
|
|
6
|
GO:0000982
|
transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
|
|
2.754E-5
|
1.237E-4
|
4.982E-4
|
8.539E-4
|
4
|
365
|
|
7
|
GO:0001085
|
RNA polymerase II transcription factor binding
|
|
2.864E-5
|
1.237E-4
|
4.982E-4
|
8.877E-4
|
3
|
118
|
|
8
|
GO:0000978
|
RNA polymerase II proximal promoter sequence-specific DNA binding
|
|
3.192E-5
|
1.237E-4
|
4.982E-4
|
9.896E-4
|
4
|
379
|
|
9
|
GO:0000987
|
proximal promoter sequence-specific DNA binding
|
|
3.866E-5
|
1.332E-4
|
5.363E-4
|
1.198E-3
|
4
|
398
|
|
10
|
GO:0043425
|
bHLH transcription factor binding
|
|
1.115E-4
|
3.458E-4
|
1.392E-3
|
3.458E-3
|
2
|
30
|
|
11
|
GO:0001102
|
RNA polymerase II activating transcription factor binding
|
|
1.798E-4
|
5.068E-4
|
2.041E-3
|
5.575E-3
|
2
|
38
|
|
12
|
GO:0001077
|
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
|
|
2.951E-4
|
7.622E-4
|
3.070E-3
|
9.147E-3
|
3
|
259
|
|
13
|
GO:0033613
|
activating transcription factor binding
|
|
4.651E-4
|
1.109E-3
|
4.466E-3
|
1.442E-2
|
2
|
61
|
|
14
|
GO:0000980
|
RNA polymerase II distal enhancer sequence-specific DNA binding
|
|
6.297E-4
|
1.394E-3
|
5.616E-3
|
1.952E-2
|
2
|
71
|
|
15
|
GO:0001158
|
enhancer sequence-specific DNA binding
|
|
1.077E-3
|
2.226E-3
|
8.966E-3
|
3.340E-2
|
2
|
93
|
|
16
|
GO:0003705
|
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
|
|
1.345E-3
|
2.499E-3
|
1.006E-2
|
4.168E-2
|
2
|
104
|
|
17
|
GO:0035326
|
enhancer binding
|
|
1.396E-3
|
2.499E-3
|
1.006E-2
|
4.328E-2
|
2
|
106
|
|
18
|
GO:0070644
|
vitamin D response element binding
|
|
1.607E-3
|
2.499E-3
|
1.006E-2
|
4.981E-2
|
1
|
3
|
|
19
|
GO:0001078
|
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
|
|
1.612E-3
|
2.499E-3
|
1.006E-2
|
4.998E-2
|
2
|
114
|
|
20
|
GO:0042826
|
histone deacetylase binding
|
|
1.612E-3
|
2.499E-3
|
1.006E-2
|
4.998E-2
|
2
|
114
|
|
21
|
GO:0001227
|
DNA-binding transcription repressor activity, RNA polymerase II-specific
|
|
4.044E-3
|
5.969E-3
|
2.404E-2
|
1.253E-1
|
2
|
182
|
|
22
|
GO:0003713
|
transcription coactivator activity
|
|
1.134E-2
|
1.597E-2
|
6.432E-2
|
3.514E-1
|
2
|
310
|
|
23
|
GO:0031435
|
mitogen-activated protein kinase kinase kinase binding
|
|
1.226E-2
|
1.652E-2
|
6.655E-2
|
3.801E-1
|
1
|
23
|
|
24
|
GO:0001205
|
distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific
|
|
1.596E-2
|
2.062E-2
|
8.304E-2
|
4.949E-1
|
1
|
30
|
|
25
|
GO:0070491
|
repressing transcription factor binding
|
|
3.170E-2
|
3.931E-2
|
1.583E-1
|
9.827E-1
|
1
|
60
|
|
26
|
GO:0000979
|
RNA polymerase II core promoter sequence-specific DNA binding
|
|
3.482E-2
|
4.151E-2
|
1.672E-1
|
1.000E0
|
1
|
66
|
Show 21 more annotations
|
2: GO: Biological Process [Display Chart]
9 input genes in category / 525 annotations before applied cutoff / 18623 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
GO:2000980
|
regulation of inner ear receptor cell differentiation
|
|
3.165E-12
|
5.539E-10
|
3.790E-9
|
1.662E-9
|
4
|
9
|
|
2
|
GO:0045631
|
regulation of mechanoreceptor differentiation
|
|
3.165E-12
|
5.539E-10
|
3.790E-9
|
1.662E-9
|
4
|
9
|
|
3
|
GO:0045607
|
regulation of inner ear auditory receptor cell differentiation
|
|
3.165E-12
|
5.539E-10
|
3.790E-9
|
1.662E-9
|
4
|
9
|
|
4
|
GO:0042491
|
inner ear auditory receptor cell differentiation
|
|
2.792E-9
|
3.665E-7
|
2.507E-6
|
1.466E-6
|
4
|
42
|
|
5
|
GO:0002065
|
columnar/cuboidal epithelial cell differentiation
|
|
4.301E-9
|
4.242E-7
|
2.902E-6
|
2.258E-6
|
5
|
153
|
|
6
|
GO:0045604
|
regulation of epidermal cell differentiation
|
|
4.847E-9
|
4.242E-7
|
2.902E-6
|
2.545E-6
|
4
|
48
|
|
7
|
GO:0035315
|
hair cell differentiation
|
|
5.735E-9
|
4.301E-7
|
2.943E-6
|
3.011E-6
|
4
|
50
|
|
8
|
GO:0045682
|
regulation of epidermis development
|
|
2.020E-8
|
1.232E-6
|
8.427E-6
|
1.061E-5
|
4
|
68
|
|
9
|
GO:0048839
|
inner ear development
|
|
2.112E-8
|
1.232E-6
|
8.427E-6
|
1.109E-5
|
5
|
210
|
|
10
|
GO:0060113
|
inner ear receptor cell differentiation
|
|
2.550E-8
|
1.339E-6
|
9.158E-6
|
1.339E-5
|
4
|
72
|
|
11
|
GO:0042490
|
mechanoreceptor differentiation
|
|
3.531E-8
|
1.685E-6
|
1.153E-5
|
1.854E-5
|
4
|
78
|
|
12
|
GO:0043583
|
ear development
|
|
4.034E-8
|
1.765E-6
|
1.208E-5
|
2.118E-5
|
5
|
239
|
|
13
|
GO:0060563
|
neuroepithelial cell differentiation
|
|
6.308E-8
|
2.548E-6
|
1.743E-5
|
3.312E-5
|
4
|
90
|
|
14
|
GO:0045165
|
cell fate commitment
|
|
7.982E-8
|
2.993E-6
|
2.048E-5
|
4.191E-5
|
5
|
274
|
|
15
|
GO:0061027
|
umbilical cord development
|
|
2.076E-7
|
6.412E-6
|
4.387E-5
|
1.090E-4
|
2
|
2
|
|
16
|
GO:2000820
|
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
|
|
2.076E-7
|
6.412E-6
|
4.387E-5
|
1.090E-4
|
2
|
2
|
|
17
|
GO:0036304
|
umbilical cord morphogenesis
|
|
2.076E-7
|
6.412E-6
|
4.387E-5
|
1.090E-4
|
2
|
2
|
|
18
|
GO:0030856
|
regulation of epithelial cell differentiation
|
|
3.744E-7
|
1.092E-5
|
7.471E-5
|
1.966E-4
|
4
|
140
|
|
19
|
GO:2000677
|
regulation of transcription regulatory region DNA binding
|
|
7.642E-7
|
2.112E-5
|
1.445E-4
|
4.012E-4
|
3
|
40
|
|
20
|
GO:0048568
|
embryonic organ development
|
|
1.276E-6
|
3.348E-5
|
2.291E-4
|
6.697E-4
|
5
|
479
|
|
21
|
GO:0009913
|
epidermal cell differentiation
|
|
1.559E-6
|
3.899E-5
|
2.667E-4
|
8.187E-4
|
4
|
200
|
|
22
|
GO:0003199
|
endocardial cushion to mesenchymal transition involved in heart valve formation
|
|
2.075E-6
|
4.735E-5
|
3.240E-4
|
1.089E-3
|
2
|
5
|
|
23
|
GO:0035912
|
dorsal aorta morphogenesis
|
|
2.075E-6
|
4.735E-5
|
3.240E-4
|
1.089E-3
|
2
|
5
|
|
24
|
GO:0035907
|
dorsal aorta development
|
|
3.111E-6
|
6.282E-5
|
4.298E-4
|
1.633E-3
|
2
|
6
|
|
25
|
GO:0060842
|
arterial endothelial cell differentiation
|
|
3.111E-6
|
6.282E-5
|
4.298E-4
|
1.633E-3
|
2
|
6
|
|
26
|
GO:0090500
|
endocardial cushion to mesenchymal transition
|
|
3.111E-6
|
6.282E-5
|
4.298E-4
|
1.633E-3
|
2
|
6
|
|
27
|
GO:0003190
|
atrioventricular valve formation
|
|
7.461E-6
|
1.399E-4
|
9.571E-4
|
3.917E-3
|
2
|
9
|
|
28
|
GO:0060837
|
blood vessel endothelial cell differentiation
|
|
7.461E-6
|
1.399E-4
|
9.571E-4
|
3.917E-3
|
2
|
9
|
|
29
|
GO:0003184
|
pulmonary valve morphogenesis
|
|
9.324E-6
|
1.579E-4
|
1.080E-3
|
4.895E-3
|
2
|
10
|
|
30
|
GO:0061314
|
Notch signaling involved in heart development
|
|
9.324E-6
|
1.579E-4
|
1.080E-3
|
4.895E-3
|
2
|
10
|
|
31
|
GO:0003177
|
pulmonary valve development
|
|
9.324E-6
|
1.579E-4
|
1.080E-3
|
4.895E-3
|
2
|
10
|
|
32
|
GO:0008544
|
epidermis development
|
|
1.279E-5
|
2.099E-4
|
1.436E-3
|
6.717E-3
|
4
|
340
|
|
33
|
GO:0051101
|
regulation of DNA binding
|
|
1.597E-5
|
2.422E-4
|
1.657E-3
|
8.384E-3
|
3
|
109
|
|
34
|
GO:2001212
|
regulation of vasculogenesis
|
|
1.615E-5
|
2.422E-4
|
1.657E-3
|
8.478E-3
|
2
|
13
|
|
35
|
GO:0003222
|
ventricular trabecula myocardium morphogenesis
|
|
1.615E-5
|
2.422E-4
|
1.657E-3
|
8.478E-3
|
2
|
13
|
|
36
|
GO:0045666
|
positive regulation of neuron differentiation
|
|
1.902E-5
|
2.773E-4
|
1.897E-3
|
9.985E-3
|
4
|
376
|
|
37
|
GO:0060347
|
heart trabecula formation
|
|
2.173E-5
|
3.083E-4
|
2.109E-3
|
1.141E-2
|
2
|
15
|
|
38
|
GO:0003188
|
heart valve formation
|
|
2.483E-5
|
3.430E-4
|
2.347E-3
|
1.303E-2
|
2
|
16
|
|
39
|
GO:0072148
|
epithelial cell fate commitment
|
|
3.164E-5
|
4.259E-4
|
2.914E-3
|
1.661E-2
|
2
|
18
|
|
40
|
GO:2000678
|
negative regulation of transcription regulatory region DNA binding
|
|
3.535E-5
|
4.527E-4
|
3.097E-3
|
1.856E-2
|
2
|
19
|
|
41
|
GO:0003181
|
atrioventricular valve morphogenesis
|
|
3.535E-5
|
4.527E-4
|
3.097E-3
|
1.856E-2
|
2
|
19
|
|
42
|
GO:0050769
|
positive regulation of neurogenesis
|
|
4.377E-5
|
5.471E-4
|
3.743E-3
|
2.298E-2
|
4
|
465
|
|
43
|
GO:0003171
|
atrioventricular valve development
|
|
4.772E-5
|
5.694E-4
|
3.895E-3
|
2.505E-2
|
2
|
22
|
|
44
|
GO:0060716
|
labyrinthine layer blood vessel development
|
|
4.772E-5
|
5.694E-4
|
3.895E-3
|
2.505E-2
|
2
|
22
|
|
45
|
GO:0061311
|
cell surface receptor signaling pathway involved in heart development
|
|
5.699E-5
|
6.648E-4
|
4.549E-3
|
2.992E-2
|
2
|
24
|
|
46
|
GO:0007219
|
Notch signaling pathway
|
|
6.799E-5
|
7.759E-4
|
5.309E-3
|
3.569E-2
|
3
|
177
|
|
47
|
GO:0060317
|
cardiac epithelial to mesenchymal transition
|
|
7.242E-5
|
7.921E-4
|
5.419E-3
|
3.802E-2
|
2
|
27
|
|
48
|
GO:0060343
|
trabecula formation
|
|
7.242E-5
|
7.921E-4
|
5.419E-3
|
3.802E-2
|
2
|
27
|
|
49
|
GO:0035909
|
aorta morphogenesis
|
|
7.797E-5
|
8.354E-4
|
5.715E-3
|
4.093E-2
|
2
|
28
|
|
50
|
GO:0061384
|
heart trabecula morphogenesis
|
|
8.372E-5
|
8.791E-4
|
6.014E-3
|
4.395E-2
|
2
|
29
|
Show 45 more annotations
|
3: GO: Cellular Component [Display Chart]
10 input genes in category / 19 annotations before applied cutoff / 19061 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
GO:0005667
|
transcription factor complex
|
|
2.618E-5
|
4.975E-4
|
1.765E-3
|
4.975E-4
|
4
|
368
|
|
2
|
GO:0000118
|
histone deacetylase complex
|
|
4.756E-4
|
2.538E-3
|
9.006E-3
|
9.037E-3
|
2
|
63
|
|
3
|
GO:0033193
|
Lsd1/2 complex
|
|
5.246E-4
|
2.538E-3
|
9.006E-3
|
9.968E-3
|
1
|
1
|
|
4
|
GO:0000790
|
nuclear chromatin
|
|
5.344E-4
|
2.538E-3
|
9.006E-3
|
1.015E-2
|
3
|
324
|
|
5
|
GO:0090575
|
RNA polymerase II transcription factor complex
|
|
1.314E-3
|
4.994E-3
|
1.772E-2
|
2.497E-2
|
2
|
105
|
|
6
|
GO:0000785
|
chromatin
|
|
1.740E-3
|
5.509E-3
|
1.954E-2
|
3.305E-2
|
3
|
487
|
|
7
|
GO:0044798
|
nuclear transcription factor complex
|
|
2.127E-3
|
5.774E-3
|
2.049E-2
|
4.042E-2
|
2
|
134
|
|
8
|
GO:0072546
|
ER membrane protein complex
|
|
5.235E-3
|
1.243E-2
|
4.411E-2
|
9.947E-2
|
1
|
10
|
|
9
|
GO:0016580
|
Sin3 complex
|
|
7.322E-3
|
1.546E-2
|
5.484E-2
|
1.391E-1
|
1
|
14
|
|
10
|
GO:0070822
|
Sin3-type complex
|
|
8.885E-3
|
1.688E-2
|
5.989E-2
|
1.688E-1
|
1
|
17
|
|
11
|
GO:0000788
|
nuclear nucleosome
|
|
2.182E-2
|
3.769E-2
|
1.337E-1
|
4.146E-1
|
1
|
42
|
Show 6 more annotations
|
4: Human Phenotype [Display Chart]
3 input genes in category / 143 annotations before applied cutoff / 4707 genes in category
|
5: Mouse Phenotype [Display Chart]
9 input genes in category / 625 annotations before applied cutoff / 10355 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
MP:0000951
|
sporadic seizures
|
|
2.931E-6
|
1.832E-3
|
1.285E-2
|
1.832E-3
|
3
|
35
|
|
2
|
MP:0001689
|
incomplete somite formation
|
|
1.102E-5
|
3.442E-3
|
2.415E-2
|
6.884E-3
|
3
|
54
|
|
3
|
MP:0000292
|
distended pericardium
|
|
2.212E-5
|
4.608E-3
|
3.233E-2
|
1.383E-2
|
3
|
68
|
|
4
|
MP:0008803
|
abnormal placental labyrinth vasculature morphology
|
|
7.038E-5
|
7.969E-3
|
5.591E-2
|
4.399E-2
|
3
|
100
|
|
5
|
MP:0004787
|
abnormal dorsal aorta morphology
|
|
8.855E-5
|
7.969E-3
|
5.591E-2
|
5.534E-2
|
3
|
108
|
|
6
|
MP:0006128
|
pulmonary valve stenosis
|
|
9.071E-5
|
7.969E-3
|
5.591E-2
|
5.670E-2
|
2
|
17
|
|
7
|
MP:0001722
|
pale yolk sac
|
|
9.608E-5
|
7.969E-3
|
5.591E-2
|
6.005E-2
|
3
|
111
|
|
8
|
MP:0010432
|
common ventricle
|
|
1.020E-4
|
7.969E-3
|
5.591E-2
|
6.375E-2
|
2
|
18
|
|
9
|
MP:0009768
|
impaired somite development
|
|
1.401E-4
|
8.434E-3
|
5.917E-2
|
8.755E-2
|
3
|
126
|
|
10
|
MP:0006344
|
small second pharyngeal arch
|
|
1.683E-4
|
8.434E-3
|
5.917E-2
|
1.052E-1
|
2
|
23
|
|
11
|
MP:0010449
|
heart right ventricle outflow tract stenosis
|
|
1.683E-4
|
8.434E-3
|
5.917E-2
|
1.052E-1
|
2
|
23
|
|
12
|
MP:0010601
|
thick pulmonary valve
|
|
1.835E-4
|
8.434E-3
|
5.917E-2
|
1.147E-1
|
2
|
24
|
|
13
|
MP:0000293
|
absent myocardial trabeculae
|
|
1.994E-4
|
8.434E-3
|
5.917E-2
|
1.246E-1
|
2
|
25
|
|
14
|
MP:0000873
|
thin external granule cell layer
|
|
1.994E-4
|
8.434E-3
|
5.917E-2
|
1.246E-1
|
2
|
25
|
|
15
|
MP:0003231
|
abnormal placenta vasculature
|
|
2.081E-4
|
8.434E-3
|
5.917E-2
|
1.300E-1
|
3
|
144
|
|
16
|
MP:0006341
|
small first pharyngeal arch
|
|
2.159E-4
|
8.434E-3
|
5.917E-2
|
1.349E-1
|
2
|
26
|
|
17
|
MP:0010406
|
common atrium
|
|
2.693E-4
|
9.893E-3
|
6.941E-2
|
1.683E-1
|
2
|
29
|
|
18
|
MP:0000852
|
small cerebellum
|
|
3.055E-4
|
9.893E-3
|
6.941E-2
|
1.909E-1
|
3
|
164
|
|
19
|
MP:0008825
|
abnormal cardiac epithelial to mesenchymal transition
|
|
3.082E-4
|
9.893E-3
|
6.941E-2
|
1.926E-1
|
2
|
31
|
|
20
|
MP:0003410
|
abnormal artery development
|
|
3.166E-4
|
9.893E-3
|
6.941E-2
|
1.979E-1
|
3
|
166
|
|
21
|
MP:0004783
|
abnormal cardinal vein morphology
|
|
3.937E-4
|
1.172E-2
|
8.220E-2
|
2.460E-1
|
2
|
35
|
|
22
|
MP:0012253
|
abnormal intersomitic vessel morphology
|
|
4.166E-4
|
1.184E-2
|
8.304E-2
|
2.604E-1
|
2
|
36
|
|
23
|
MP:0002725
|
abnormal vein morphology
|
|
4.493E-4
|
1.221E-2
|
8.567E-2
|
2.808E-1
|
3
|
187
|
|
24
|
MP:0001716
|
abnormal placenta labyrinth morphology
|
|
4.781E-4
|
1.245E-2
|
8.736E-2
|
2.988E-1
|
3
|
191
|
|
25
|
MP:0008772
|
increased heart ventricle size
|
|
6.224E-4
|
1.556E-2
|
1.092E-1
|
3.890E-1
|
3
|
209
|
|
26
|
MP:0001725
|
abnormal umbilical cord morphology
|
|
6.814E-4
|
1.577E-2
|
1.107E-1
|
4.259E-1
|
2
|
46
|
|
27
|
MP:0006338
|
abnormal second pharyngeal arch morphology
|
|
6.814E-4
|
1.577E-2
|
1.107E-1
|
4.259E-1
|
2
|
46
|
|
28
|
MP:0001718
|
abnormal visceral yolk sac morphology
|
|
8.334E-4
|
1.811E-2
|
1.270E-1
|
5.209E-1
|
3
|
231
|
|
29
|
MP:0008824
|
absent interventricular septum membranous part
|
|
8.691E-4
|
1.811E-2
|
1.270E-1
|
5.432E-1
|
1
|
1
|
|
30
|
MP:0003310
|
reduced modiolus
|
|
8.691E-4
|
1.811E-2
|
1.270E-1
|
5.432E-1
|
1
|
1
|
|
31
|
MP:0001688
|
abnormal somite development
|
|
9.656E-4
|
1.947E-2
|
1.366E-1
|
6.035E-1
|
3
|
243
|
|
32
|
MP:0000295
|
trabecula carnea hypoplasia
|
|
1.120E-3
|
2.187E-2
|
1.534E-1
|
6.999E-1
|
2
|
59
|
|
33
|
MP:0006006
|
increased sensory neuron number
|
|
1.158E-3
|
2.193E-2
|
1.539E-1
|
7.237E-1
|
2
|
60
|
|
34
|
MP:0006337
|
abnormal first pharyngeal arch morphology
|
|
1.236E-3
|
2.207E-2
|
1.548E-1
|
7.725E-1
|
2
|
62
|
|
35
|
MP:0002748
|
abnormal pulmonary valve morphology
|
|
1.236E-3
|
2.207E-2
|
1.548E-1
|
7.725E-1
|
2
|
62
|
|
36
|
MP:0000288
|
abnormal pericardium morphology
|
|
1.311E-3
|
2.275E-2
|
1.596E-1
|
8.191E-1
|
3
|
270
|
|
37
|
MP:0006346
|
small pharyngeal arch
|
|
1.442E-3
|
2.413E-2
|
1.693E-1
|
9.012E-1
|
2
|
67
|
|
38
|
MP:0010428
|
abnormal heart right ventricle outflow tract morphology
|
|
1.529E-3
|
2.413E-2
|
1.693E-1
|
9.553E-1
|
2
|
69
|
|
39
|
MP:0002625
|
heart left ventricle hypertrophy
|
|
1.663E-3
|
2.413E-2
|
1.693E-1
|
1.000E0
|
2
|
72
|
|
40
|
MP:0010503
|
myocardial trabeculae hypoplasia
|
|
1.709E-3
|
2.413E-2
|
1.693E-1
|
1.000E0
|
2
|
73
|
|
41
|
MP:0010916
|
decreased solitary pulmonary neuroendocrine cell number
|
|
1.738E-3
|
2.413E-2
|
1.693E-1
|
1.000E0
|
1
|
2
|
|
42
|
MP:0003309
|
abnormal modiolus morphology
|
|
1.738E-3
|
2.413E-2
|
1.693E-1
|
1.000E0
|
1
|
2
|
|
43
|
MP:0006044
|
tricuspid valve regurgitation
|
|
1.738E-3
|
2.413E-2
|
1.693E-1
|
1.000E0
|
1
|
2
|
|
44
|
MP:0006124
|
tricuspid valve stenosis
|
|
1.738E-3
|
2.413E-2
|
1.693E-1
|
1.000E0
|
1
|
2
|
|
45
|
MP:0000874
|
irregular external granule cell layer thickness
|
|
1.738E-3
|
2.413E-2
|
1.693E-1
|
1.000E0
|
1
|
2
|
|
46
|
MP:0003411
|
abnormal vein development
|
|
1.803E-3
|
2.450E-2
|
1.719E-1
|
1.000E0
|
2
|
75
|
|
47
|
MP:0003997
|
tonic-clonic seizures
|
|
1.900E-3
|
2.473E-2
|
1.735E-1
|
1.000E0
|
2
|
77
|
|
48
|
MP:0004076
|
abnormal vitelline vascular remodeling
|
|
1.900E-3
|
2.473E-2
|
1.735E-1
|
1.000E0
|
2
|
77
|
|
49
|
MP:0008127
|
decreased dendritic cell number
|
|
1.949E-3
|
2.486E-2
|
1.744E-1
|
1.000E0
|
2
|
78
|
|
50
|
MP:0000872
|
abnormal cerebellum external granule cell layer morphology
|
|
2.100E-3
|
2.625E-2
|
1.841E-1
|
1.000E0
|
2
|
81
|
Show 45 more annotations
|
6: Domain [Display Chart]
10 input genes in category / 22 annotations before applied cutoff / 18735 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
4.10.280.10
|
-
|
Gene3D
|
5.425E-20
|
5.412E-19
|
1.998E-18
|
1.193E-18
|
9
|
109
|
|
2
|
PF00010
|
HLH
|
Pfam
|
6.990E-20
|
5.412E-19
|
1.998E-18
|
1.538E-18
|
9
|
112
|
|
3
|
SM00353
|
HLH
|
SMART
|
1.050E-19
|
5.412E-19
|
1.998E-18
|
2.311E-18
|
9
|
117
|
|
4
|
PS50888
|
BHLH
|
PROSITE
|
1.137E-19
|
5.412E-19
|
1.998E-18
|
2.502E-18
|
9
|
118
|
|
5
|
IPR011598
|
bHLH dom
|
InterPro
|
1.230E-19
|
5.412E-19
|
1.998E-18
|
2.706E-18
|
9
|
119
|
|
6
|
PF12533
|
Neuro bHLH
|
Pfam
|
1.538E-6
|
4.229E-6
|
1.561E-5
|
3.383E-5
|
2
|
4
|
|
7
|
IPR016637
|
TF bHLH NeuroD
|
InterPro
|
1.538E-6
|
4.229E-6
|
1.561E-5
|
3.383E-5
|
2
|
4
|
|
8
|
IPR022575
|
Neurogenic DUF
|
InterPro
|
1.538E-6
|
4.229E-6
|
1.561E-5
|
3.383E-5
|
2
|
4
|
|
9
|
SM00511
|
ORANGE
|
SMART
|
9.213E-6
|
2.252E-5
|
8.312E-5
|
2.027E-4
|
2
|
9
|
|
10
|
PF07527
|
Hairy orange
|
Pfam
|
1.688E-5
|
3.375E-5
|
1.246E-4
|
3.713E-4
|
2
|
12
|
|
11
|
IPR003650
|
Orange dom
|
InterPro
|
1.688E-5
|
3.375E-5
|
1.246E-4
|
3.713E-4
|
2
|
12
|
|
12
|
PS51054
|
ORANGE
|
PROSITE
|
1.994E-5
|
3.655E-5
|
1.349E-4
|
4.386E-4
|
2
|
13
|
|
13
|
IPR032661
|
ATOH1
|
InterPro
|
5.338E-4
|
7.828E-4
|
2.889E-3
|
1.174E-2
|
1
|
1
|
|
14
|
IPR032649
|
Neurod2
|
InterPro
|
5.338E-4
|
7.828E-4
|
2.889E-3
|
1.174E-2
|
1
|
1
|
|
15
|
IPR032652
|
Neurod1
|
InterPro
|
5.338E-4
|
7.828E-4
|
2.889E-3
|
1.174E-2
|
1
|
1
|
|
16
|
PF03665
|
UPF0172
|
Pfam
|
1.067E-3
|
1.381E-3
|
5.098E-3
|
2.348E-2
|
1
|
2
|
|
17
|
IPR005366
|
EMC8/9
|
InterPro
|
1.067E-3
|
1.381E-3
|
5.098E-3
|
2.348E-2
|
1
|
2
|
|
18
|
IPR002418
|
Tscrpt reg Myc
|
InterPro
|
2.134E-3
|
2.347E-3
|
8.662E-3
|
4.694E-2
|
1
|
4
|
|
19
|
PF01056
|
Myc N
|
Pfam
|
2.134E-3
|
2.347E-3
|
8.662E-3
|
4.694E-2
|
1
|
4
|
|
20
|
IPR012682
|
Tscrpt reg Myc N
|
InterPro
|
2.134E-3
|
2.347E-3
|
8.662E-3
|
4.694E-2
|
1
|
4
|
|
21
|
IPR008983
|
Tumour necrosis fac-like dom
|
InterPro
|
3.054E-2
|
3.199E-2
|
1.181E-1
|
6.718E-1
|
1
|
58
|
Show 16 more annotations
|
7: Pathway [Display Chart]
6 input genes in category / 29 annotations before applied cutoff / 12450 genes in category
|
8: Pubmed [Display Chart]
10 input genes in category / 2218 annotations before applied cutoff / 38193 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
18557763
|
Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.
|
Pubmed
|
3.299E-23
|
7.316E-20
|
6.059E-19
|
7.316E-20
|
9
|
98
|
|
2
|
25232121
|
Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling.
|
Pubmed
|
1.292E-10
|
1.433E-7
|
1.187E-6
|
2.866E-7
|
3
|
5
|
|
3
|
10924525
|
The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function.
|
Pubmed
|
4.521E-10
|
2.507E-7
|
2.076E-6
|
1.003E-6
|
3
|
7
|
|
4
|
11076679
|
Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors.
|
Pubmed
|
4.521E-10
|
2.507E-7
|
2.076E-6
|
1.003E-6
|
3
|
7
|
|
5
|
16043483
|
MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters.
|
Pubmed
|
7.233E-10
|
3.208E-7
|
2.657E-6
|
1.604E-6
|
3
|
8
|
|
6
|
18291358
|
Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea.
|
Pubmed
|
1.549E-9
|
5.728E-7
|
4.744E-6
|
3.437E-6
|
3
|
10
|
|
7
|
18302773
|
Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development.
|
Pubmed
|
2.130E-9
|
6.750E-7
|
5.590E-6
|
4.725E-6
|
3
|
11
|
|
8
|
21781958
|
Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis.
|
Pubmed
|
5.871E-9
|
1.602E-6
|
1.327E-5
|
1.302E-5
|
3
|
15
|
|
9
|
16061358
|
Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.
|
Pubmed
|
7.225E-9
|
1.602E-6
|
1.327E-5
|
1.602E-5
|
3
|
16
|
|
10
|
21300049
|
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.
|
Pubmed
|
7.225E-9
|
1.602E-6
|
1.327E-5
|
1.602E-5
|
3
|
16
|
|
11
|
15689374
|
RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.
|
Pubmed
|
1.052E-8
|
2.122E-6
|
1.758E-5
|
2.334E-5
|
3
|
18
|
|
12
|
23946445
|
Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea.
|
Pubmed
|
1.250E-8
|
2.310E-6
|
1.913E-5
|
2.772E-5
|
3
|
19
|
|
13
|
23193000
|
Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability.
|
Pubmed
|
1.470E-8
|
2.508E-6
|
2.077E-5
|
3.260E-5
|
3
|
20
|
|
14
|
21420948
|
Rbpj regulates development of prosensory cells in the mammalian inner ear.
|
Pubmed
|
2.608E-8
|
4.132E-6
|
3.422E-5
|
5.785E-5
|
3
|
24
|
|
15
|
16000382
|
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.
|
Pubmed
|
5.787E-8
|
5.474E-6
|
4.533E-5
|
1.284E-4
|
3
|
31
|
|
16
|
9507011
|
The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition.
|
Pubmed
|
6.170E-8
|
5.474E-6
|
4.533E-5
|
1.369E-4
|
2
|
2
|
|
17
|
11900979
|
The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion.
|
Pubmed
|
6.170E-8
|
5.474E-6
|
4.533E-5
|
1.369E-4
|
2
|
2
|
|
18
|
18069799
|
Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition.
|
Pubmed
|
6.170E-8
|
5.474E-6
|
4.533E-5
|
1.369E-4
|
2
|
2
|
|
19
|
19272376
|
Synergistic nuclear import of NeuroD1 and its partner transcription factor, E47, via heterodimerization.
|
Pubmed
|
6.170E-8
|
5.474E-6
|
4.533E-5
|
1.369E-4
|
2
|
2
|
|
20
|
15314159
|
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.
|
Pubmed
|
6.170E-8
|
5.474E-6
|
4.533E-5
|
1.369E-4
|
2
|
2
|
|
21
|
11439353
|
The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice.
|
Pubmed
|
6.170E-8
|
5.474E-6
|
4.533E-5
|
1.369E-4
|
2
|
2
|
|
22
|
25361534
|
Notch Signaling Target Genes are Directly Correlated to Esophageal Squamous Cell Carcinoma Tumorigenesis.
|
Pubmed
|
6.170E-8
|
5.474E-6
|
4.533E-5
|
1.369E-4
|
2
|
2
|
|
23
|
25446183
|
Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes.
|
Pubmed
|
6.170E-8
|
5.474E-6
|
4.533E-5
|
1.369E-4
|
2
|
2
|
|
24
|
19609565
|
Defects in the cerebella of conditional Neurod1 null mice correlate with effective Tg(Atoh1-cre) recombination and granule cell requirements for Neurod1 for differentiation.
|
Pubmed
|
6.170E-8
|
5.474E-6
|
4.533E-5
|
1.369E-4
|
2
|
2
|
|
25
|
11486044
|
HERP, a new primary target of Notch regulated by ligand binding.
|
Pubmed
|
6.170E-8
|
5.474E-6
|
4.533E-5
|
1.369E-4
|
2
|
2
|
|
26
|
17476283
|
The notch pathway positively regulates programmed cell death during erythroid differentiation.
|
Pubmed
|
1.270E-7
|
8.924E-6
|
7.391E-5
|
2.818E-4
|
3
|
40
|
|
27
|
29107558
|
ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development.
|
Pubmed
|
1.270E-7
|
8.924E-6
|
7.391E-5
|
2.818E-4
|
3
|
40
|
|
28
|
15193261
|
TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
29
|
8159721
|
Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
30
|
10373552
|
Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
31
|
10415358
|
Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
32
|
25799559
|
Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
33
|
11741889
|
HERP1 is a cell type-specific primary target of Notch.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
34
|
18550854
|
Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
35
|
17924961
|
Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
36
|
10545951
|
Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
37
|
16165016
|
Hesr, a mediator of the Notch signaling, functions in heart and vessel development.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
38
|
22310718
|
NeuroD1 is an upstream regulator of NSCL1.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
39
|
10636926
|
Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
40
|
8760303
|
The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
41
|
12548545
|
HES and HERP families: multiple effectors of the Notch signaling pathway.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
42
|
10692439
|
Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
43
|
8816493
|
NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
44
|
14576336
|
Neurogenin3 activates the islet differentiation program while repressing its own expression.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
45
|
10588864
|
HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
46
|
21593321
|
NeuroD factors regulate cell fate and neurite stratification in the developing retina.
|
Pubmed
|
1.851E-7
|
8.924E-6
|
7.391E-5
|
4.105E-4
|
2
|
3
|
|
47
|
11756538
|
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.
|
Pubmed
|
3.701E-7
|
1.263E-5
|
1.046E-4
|
8.209E-4
|
2
|
4
|
|
48
|
18039969
|
Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development.
|
Pubmed
|
3.701E-7
|
1.263E-5
|
1.046E-4
|
8.209E-4
|
2
|
4
|
|
49
|
16145671
|
Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit.
|
Pubmed
|
3.701E-7
|
1.263E-5
|
1.046E-4
|
8.209E-4
|
2
|
4
|
|
50
|
29155305
|
Hey1 and Hey2 are differently expressed during mouse tooth development.
|
Pubmed
|
3.701E-7
|
1.263E-5
|
1.046E-4
|
8.209E-4
|
2
|
4
|
Show 45 more annotations
|
9: Interaction [Display Chart]
10 input genes in category / 530 annotations before applied cutoff / 17703 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
int:TCF12
|
TCF12 interactions
|
|
1.170E-7
|
6.201E-5
|
4.248E-4
|
6.201E-5
|
4
|
88
|
|
2
|
int:TRRAP
|
TRRAP interactions
|
|
5.295E-7
|
1.403E-4
|
9.612E-4
|
2.806E-4
|
4
|
128
|
|
3
|
int:RUNX1T1
|
RUNX1T1 interactions
|
|
6.669E-6
|
9.330E-4
|
6.392E-3
|
3.534E-3
|
3
|
69
|
|
4
|
int:TCF3
|
TCF3 interactions
|
|
7.041E-6
|
9.330E-4
|
6.392E-3
|
3.732E-3
|
4
|
245
|
|
5
|
int:LYL1
|
LYL1 interactions
|
|
1.890E-5
|
2.003E-3
|
1.372E-2
|
1.002E-2
|
2
|
12
|
|
6
|
int:PDX1
|
PDX1 interactions
|
|
4.886E-5
|
3.595E-3
|
2.463E-2
|
2.590E-2
|
2
|
19
|
|
7
|
int:HAND2
|
HAND2 interactions
|
|
5.427E-5
|
3.595E-3
|
2.463E-2
|
2.876E-2
|
2
|
20
|
|
8
|
int:HAND1
|
HAND1 interactions
|
|
5.427E-5
|
3.595E-3
|
2.463E-2
|
2.876E-2
|
2
|
20
|
|
9
|
int:CCDC124
|
CCDC124 interactions
|
|
7.874E-5
|
4.637E-3
|
3.177E-2
|
4.173E-2
|
2
|
24
|
|
10
|
int:FBXO45
|
FBXO45 interactions
|
|
1.000E-4
|
5.190E-3
|
3.556E-2
|
5.303E-2
|
2
|
27
|
|
11
|
int:HEY2
|
HEY2 interactions
|
|
1.077E-4
|
5.190E-3
|
3.556E-2
|
5.709E-2
|
2
|
28
|
|
12
|
int:NEUROD1
|
NEUROD1 interactions
|
|
1.239E-4
|
5.471E-3
|
3.748E-2
|
6.566E-2
|
2
|
30
|
|
13
|
int:IRF2BP2
|
IRF2BP2 interactions
|
|
2.327E-4
|
9.075E-3
|
6.217E-2
|
1.234E-1
|
2
|
41
|
|
14
|
int:TCF4
|
TCF4 interactions
|
|
2.397E-4
|
9.075E-3
|
6.217E-2
|
1.271E-1
|
3
|
229
|
|
15
|
int:CBFA2T3
|
CBFA2T3 interactions
|
|
3.063E-4
|
1.021E-2
|
6.996E-2
|
1.623E-1
|
2
|
47
|
|
16
|
int:DERL2
|
DERL2 interactions
|
|
3.195E-4
|
1.021E-2
|
6.996E-2
|
1.693E-1
|
2
|
48
|
|
17
|
int:TAL1
|
TAL1 interactions
|
|
3.751E-4
|
1.021E-2
|
6.996E-2
|
1.988E-1
|
2
|
52
|
|
18
|
int:RB1
|
RB1 interactions
|
|
3.764E-4
|
1.021E-2
|
6.996E-2
|
1.995E-1
|
3
|
267
|
|
19
|
int:MAPK3
|
MAPK3 interactions
|
|
3.847E-4
|
1.021E-2
|
6.996E-2
|
2.039E-1
|
3
|
269
|
|
20
|
int:DPF3
|
DPF3 interactions
|
|
3.897E-4
|
1.021E-2
|
6.996E-2
|
2.065E-1
|
2
|
53
|
|
21
|
int:HES1
|
HES1 interactions
|
|
4.046E-4
|
1.021E-2
|
6.996E-2
|
2.144E-1
|
2
|
54
|
|
22
|
int:LDB1
|
LDB1 interactions
|
|
5.333E-4
|
1.229E-2
|
8.420E-2
|
2.827E-1
|
2
|
62
|
|
23
|
int:SEL1L
|
SEL1L interactions
|
|
5.333E-4
|
1.229E-2
|
8.420E-2
|
2.827E-1
|
2
|
62
|
|
24
|
int:STK38
|
STK38 interactions
|
|
5.683E-4
|
1.255E-2
|
8.597E-2
|
3.012E-1
|
2
|
64
|
|
25
|
int:USF1
|
USF1 interactions
|
|
6.603E-4
|
1.400E-2
|
9.590E-2
|
3.500E-1
|
2
|
69
|
|
26
|
int:CALM3
|
CALM3 interactions
|
|
6.990E-4
|
1.425E-2
|
9.762E-2
|
3.705E-1
|
2
|
71
|
|
27
|
int:ATOH1
|
ATOH1 interactions
|
|
8.429E-4
|
1.655E-2
|
1.134E-1
|
4.467E-1
|
2
|
78
|
|
28
|
int:TRIM33
|
TRIM33 interactions
|
|
1.023E-3
|
1.870E-2
|
1.281E-1
|
5.424E-1
|
2
|
86
|
|
29
|
int:SON
|
SON interactions
|
|
1.023E-3
|
1.870E-2
|
1.281E-1
|
5.424E-1
|
2
|
86
|
|
30
|
int:CCDC78
|
CCDC78 interactions
|
|
1.129E-3
|
1.995E-2
|
1.367E-1
|
5.986E-1
|
1
|
2
|
|
31
|
int:RCOR1
|
RCOR1 interactions
|
|
1.299E-3
|
2.109E-2
|
1.445E-1
|
6.887E-1
|
2
|
97
|
|
32
|
int:MYOD1
|
MYOD1 interactions
|
|
1.299E-3
|
2.109E-2
|
1.445E-1
|
6.887E-1
|
2
|
97
|
|
33
|
int:AKAP9
|
AKAP9 interactions
|
|
1.326E-3
|
2.109E-2
|
1.445E-1
|
7.028E-1
|
2
|
98
|
|
34
|
int:GATA1
|
GATA1 interactions
|
|
1.353E-3
|
2.109E-2
|
1.445E-1
|
7.171E-1
|
2
|
99
|
|
35
|
int:SYVN1
|
SYVN1 interactions
|
|
1.463E-3
|
2.216E-2
|
1.518E-1
|
7.756E-1
|
2
|
103
|
|
36
|
int:SCX
|
SCX interactions
|
|
1.694E-3
|
2.302E-2
|
1.577E-1
|
8.977E-1
|
1
|
3
|
|
37
|
int:TCF24
|
TCF24 interactions
|
|
1.694E-3
|
2.302E-2
|
1.577E-1
|
8.977E-1
|
1
|
3
|
|
38
|
int:NEUROD2
|
NEUROD2 interactions
|
|
1.694E-3
|
2.302E-2
|
1.577E-1
|
8.977E-1
|
1
|
3
|
|
39
|
int:TCF15
|
TCF15 interactions
|
|
1.694E-3
|
2.302E-2
|
1.577E-1
|
8.977E-1
|
1
|
3
|
|
40
|
int:HEY1
|
HEY1 interactions
|
|
1.788E-3
|
2.306E-2
|
1.580E-1
|
9.479E-1
|
2
|
114
|
|
41
|
int:SSBP1
|
SSBP1 interactions
|
|
1.851E-3
|
2.306E-2
|
1.580E-1
|
9.810E-1
|
2
|
116
|
|
42
|
int:SERPINH1
|
SERPINH1 interactions
|
|
1.882E-3
|
2.306E-2
|
1.580E-1
|
9.977E-1
|
2
|
117
|
|
43
|
int:TLE1
|
TLE1 interactions
|
|
1.882E-3
|
2.306E-2
|
1.580E-1
|
9.977E-1
|
2
|
117
|
|
44
|
int:RUNX1
|
RUNX1 interactions
|
|
1.914E-3
|
2.306E-2
|
1.580E-1
|
1.000E0
|
2
|
118
|
|
45
|
int:NHLH2
|
NHLH2 interactions
|
|
2.258E-3
|
2.546E-2
|
1.744E-1
|
1.000E0
|
1
|
4
|
|
46
|
int:ATOH8
|
ATOH8 interactions
|
|
2.258E-3
|
2.546E-2
|
1.744E-1
|
1.000E0
|
1
|
4
|
|
47
|
int:HELT
|
HELT interactions
|
|
2.258E-3
|
2.546E-2
|
1.744E-1
|
1.000E0
|
1
|
4
|
|
48
|
int:MESP2
|
MESP2 interactions
|
|
2.822E-3
|
3.106E-2
|
2.128E-1
|
1.000E0
|
1
|
5
|
|
49
|
int:PLEC
|
PLEC interactions
|
|
2.872E-3
|
3.106E-2
|
2.128E-1
|
1.000E0
|
2
|
145
|
|
50
|
int:TUBB2A
|
TUBB2A interactions
|
|
2.950E-3
|
3.127E-2
|
2.142E-1
|
1.000E0
|
2
|
147
|
Show 45 more annotations
|
10: Cytoband [Display Chart]
10 input genes in category / 10 annotations before applied cutoff / 34661 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
4q22
|
4q22
|
|
2.594E-3
|
1.344E-2
|
3.937E-2
|
2.594E-2
|
1
|
9
|
|
2
|
8q21
|
8q21
|
|
3.457E-3
|
1.344E-2
|
3.937E-2
|
3.457E-2
|
1
|
12
|
|
3
|
2q32
|
2q32
|
|
4.032E-3
|
1.344E-2
|
3.937E-2
|
4.032E-2
|
1
|
14
|
|
4
|
1p32
|
1p32
|
|
7.763E-3
|
1.941E-2
|
5.685E-2
|
7.763E-2
|
1
|
27
|
|
5
|
19q13
|
19q13
|
|
9.767E-3
|
1.953E-2
|
5.722E-2
|
9.767E-2
|
1
|
34
|
|
6
|
1p34.2
|
1p34.2
|
|
1.661E-2
|
2.768E-2
|
8.108E-2
|
1.661E-1
|
1
|
58
|
|
7
|
6q21
|
6q21
|
|
2.933E-2
|
3.736E-2
|
1.094E-1
|
2.933E-1
|
1
|
103
|
|
8
|
17q12
|
17q12
|
|
2.989E-2
|
3.736E-2
|
1.094E-1
|
2.989E-1
|
1
|
105
|
Show 3 more annotations
|
11: Transcription Factor Binding Site [Display Chart]
9 input genes in category / 177 annotations before applied cutoff / 9770 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
V$MYOGNF1 01
|
V$MYOGNF1 01
|
|
6.372E-4
|
3.688E-2
|
2.123E-1
|
1.128E-1
|
2
|
42
|
|
2
|
V$OSF2 Q6
|
V$OSF2 Q6
|
|
7.578E-4
|
3.688E-2
|
2.123E-1
|
1.341E-1
|
3
|
211
|
|
3
|
GGCKCATGS UNKNOWN
|
GGCKCATGS UNKNOWN
|
|
7.981E-4
|
3.688E-2
|
2.123E-1
|
1.413E-1
|
2
|
47
|
|
4
|
V$CEBP 01
|
V$CEBP 01
|
|
8.334E-4
|
3.688E-2
|
2.123E-1
|
1.475E-1
|
3
|
218
|
|
5
|
GCGSCMNTTT UNKNOWN
|
GCGSCMNTTT UNKNOWN
|
|
1.053E-3
|
3.728E-2
|
2.146E-1
|
1.864E-1
|
2
|
54
|
|
12: Gene Family [Display Chart]
9 input genes in category / 1 annotations before applied cutoff / 18194 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
420
|
Basic helix-loop-helix proteins
|
genenames.org
|
7.729E-21
|
7.729E-21
|
7.729E-21
|
7.729E-21
|
9
|
110
|
|
13: Coexpression [Display Chart]
10 input genes in category / 921 annotations before applied cutoff / 23137 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
15665281-Table2
|
Human Brain Wong05 96genes
|
GeneSigDB
|
2.745E-6
|
1.624E-3
|
1.202E-2
|
2.528E-3
|
3
|
67
|
|
2
|
19235837-Table2
|
Human Pancreas Cavard09 7genes
|
GeneSigDB
|
3.527E-6
|
1.624E-3
|
1.202E-2
|
3.248E-3
|
2
|
7
|
|
3
|
19286929-SuppTable2i
|
Mouse Lung Rangasamy09 248genes
|
GeneSigDB
|
4.347E-5
|
1.229E-2
|
9.095E-2
|
4.003E-2
|
3
|
168
|
|
4
|
16455954-Table1
|
Human StemCell Dekker06 31genes
|
GeneSigDB
|
5.434E-5
|
1.229E-2
|
9.095E-2
|
5.005E-2
|
2
|
26
|
|
5
|
M2706
|
Genes up-regulated in primary epithelial breast cancer cell culture over-expressing E2F3 [Gene ID=1871] gene.
|
MSigDB C6: Oncogenic Signatures (v6.0)
|
6.670E-5
|
1.229E-2
|
9.095E-2
|
6.143E-2
|
3
|
194
|
|
6
|
M5919
|
Genes up-regulated by activation of hedgehog signaling.
|
MSigDB H: Hallmark Gene Sets (v6.0)
|
1.051E-4
|
1.613E-2
|
1.194E-1
|
9.679E-2
|
2
|
36
|
|
7
|
M5895
|
Genes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1 [GeneID=1499].
|
MSigDB H: Hallmark Gene Sets (v6.0)
|
1.434E-4
|
1.887E-2
|
1.397E-1
|
1.321E-1
|
2
|
42
|
|
8
|
M1552
|
Cluster 10: genes down-regulated in SW260 cells (colon cancer) by sodium butyrate and TSA [PubChem=5222465;5562] with the same kinetics with which each alters the level of histone H4 acetylation.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.377E-4
|
2.737E-2
|
2.026E-1
|
2.189E-1
|
2
|
54
|
|
9
|
M2248
|
Early-late response genes: differentially expressed in the first 3 h and after 12 h following UV-C irradiation of MEF cells (embryonic fibroblast).
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.847E-4
|
2.770E-2
|
2.051E-1
|
2.622E-1
|
3
|
317
|
|
10
|
M9150
|
Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
3.008E-4
|
2.770E-2
|
2.051E-1
|
2.770E-1
|
3
|
323
|
|
11
|
M1671
|
Genes up-regulated in response to hydrogen peroxide [PubChem=784] in CS-B cells (Cockayne syndrome fibroblast, CS) expressing ERCC6 [GeneID=2074] off a plasmid vector.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
4.112E-4
|
3.276E-2
|
2.426E-1
|
3.787E-1
|
2
|
71
|
|
12
|
14993899-TableS1
|
Human Futreal04 427genes ConsensusCancerGenes
|
GeneSigDB
|
4.269E-4
|
3.276E-2
|
2.426E-1
|
3.932E-1
|
3
|
364
|
|
13
|
16857994-TableS1
|
Human Leukemia Chapiro06 156genes
|
GeneSigDB
|
6.745E-4
|
4.779E-2
|
3.538E-1
|
6.212E-1
|
2
|
91
|
Show 8 more annotations
|
14: Coexpression Atlas [Display Chart]
10 input genes in category / 788 annotations before applied cutoff / 21829 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Cdkn2b
|
BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Cdkn2b
|
BrainMap
|
1.052E-6
|
8.290E-4
|
6.008E-3
|
8.290E-4
|
4
|
187
|
|
2
|
Facebase RNAseq e10.5 Neural Epithelium Overlying Central Eminence 500 K1
|
FacebaseRNAseq e10.5 Neural Epithelium Overlying Central Eminence top-relative-expression-ranked 500 k-means-cluster#1
|
FaceBase_RNAseq
|
1.247E-4
|
4.500E-2
|
3.261E-1
|
9.828E-2
|
2
|
37
|
|
3
|
BrainMap BrainAtlas - Human / Mouse Linnarsson Neuroblast Neuroblast Subtype VGLUT1 Top 200 Genes
|
BrainMap BrainAtlas - Human / Mouse Linnarsson Neuroblast Neuroblast Subtype VGLUT1 Top 200 Genes
|
BrainMap
|
2.928E-4
|
4.500E-2
|
3.261E-1
|
2.307E-1
|
3
|
302
|
|
4
|
BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Slc17a7 Neuron.mixed excitatory.Slc17a7 Subtype Neuron.mixed excitatory.Slc17a7 Hippocampus Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Slc17a7 Neuron.mixed excitatory.Slc17a7 Subtype Neuron.mixed excitatory.Slc17a7 Hippocampus Top 200 Genes
|
BrainMap
|
3.438E-4
|
4.500E-2
|
3.261E-1
|
2.709E-1
|
3
|
319
|
|
5
|
BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 Hippocampus Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 Hippocampus Top 200 Genes
|
BrainMap
|
4.937E-4
|
4.500E-2
|
3.261E-1
|
3.891E-1
|
3
|
361
|
|
6
|
BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr FrontalCortex Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr FrontalCortex Top 200 Genes
|
BrainMap
|
4.937E-4
|
4.500E-2
|
3.261E-1
|
3.891E-1
|
3
|
361
|
|
7
|
Facebase ST1 e10.5 Nasal Pit 500
|
e10.5 Nasal Pit top-relative-expression-ranked 500
|
FaceBase_ST1
|
5.018E-4
|
4.500E-2
|
3.261E-1
|
3.954E-1
|
3
|
363
|
|
8
|
BrainMap BrainAtlas - Mouse McCarroll PosteriorCortex PosteriorCortex Top 200
|
BrainMap BrainAtlas - Mouse McCarroll PosteriorCortex PosteriorCortex Top 200
|
BrainMap
|
5.140E-4
|
4.500E-2
|
3.261E-1
|
4.050E-1
|
3
|
366
|
|
9
|
BrainMap BrainAtlas - Mouse McCarroll PosteriorCortex PosteriorCortex Subtype Mural.Acta2.Rgs5.Acta2,Rgs5. PosteriorCortex Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll PosteriorCortex PosteriorCortex Subtype Mural.Acta2.Rgs5.Acta2,Rgs5. PosteriorCortex Top 200 Genes
|
BrainMap
|
5.140E-4
|
4.500E-2
|
3.261E-1
|
4.050E-1
|
3
|
366
|
Show 4 more annotations
|
15: Computational [Display Chart]
7 input genes in category / 41 annotations before applied cutoff / 10037 genes in category
|
16: MicroRNA [Display Chart]
10 input genes in category / 429 annotations before applied cutoff / 72241 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
hsa-miR-153:PITA
|
hsa-miR-153:PITA TOP
|
PITA
|
1.025E-7
|
4.399E-5
|
2.921E-4
|
4.399E-5
|
4
|
343
|
|
2
|
CTATGCA,MIR-153:MSigDB
|
CTATGCA,MIR-153:MSigDB
|
MSigDB
|
2.548E-6
|
5.465E-4
|
3.628E-3
|
1.093E-3
|
3
|
202
|
|
3
|
hsa-miR-101:PITA
|
hsa-miR-101:PITA TOP
|
PITA
|
3.358E-5
|
4.802E-3
|
3.188E-2
|
1.441E-2
|
3
|
479
|
|
4
|
hsa-miR-450b-3p:PITA
|
hsa-miR-450b-3p:PITA TOP
|
PITA
|
6.119E-5
|
5.240E-3
|
3.479E-2
|
2.625E-2
|
2
|
85
|
|
5
|
hsa-miR-769-3p:PITA
|
hsa-miR-769-3p:PITA TOP
|
PITA
|
6.264E-5
|
5.240E-3
|
3.479E-2
|
2.687E-2
|
2
|
86
|
|
6
|
CCAGGGG,MIR-331:MSigDB
|
CCAGGGG,MIR-331:MSigDB
|
MSigDB
|
7.328E-5
|
5.240E-3
|
3.479E-2
|
3.144E-2
|
2
|
93
|
|
7
|
hsa-miR-502-5p:PITA
|
hsa-miR-502-5p:PITA TOP
|
PITA
|
1.389E-4
|
7.582E-3
|
5.034E-2
|
5.958E-2
|
2
|
128
|
|
8
|
hsa-miR-1275:PITA
|
hsa-miR-1275:PITA TOP
|
PITA
|
1.499E-4
|
7.582E-3
|
5.034E-2
|
6.432E-2
|
2
|
133
|
|
9
|
hsa-miR-637:PITA
|
hsa-miR-637:PITA TOP
|
PITA
|
1.591E-4
|
7.582E-3
|
5.034E-2
|
6.824E-2
|
2
|
137
|
|
10
|
hsa-miR-885-5p:PITA
|
hsa-miR-885-5p:PITA TOP
|
PITA
|
2.305E-4
|
9.100E-3
|
6.042E-2
|
9.890E-2
|
2
|
165
|
|
11
|
hsa-miR-567:PITA
|
hsa-miR-567:PITA TOP
|
PITA
|
2.333E-4
|
9.100E-3
|
6.042E-2
|
1.001E-1
|
2
|
166
|
|
12
|
hsa-miR-329:PITA
|
hsa-miR-329:PITA TOP
|
PITA
|
3.905E-4
|
9.785E-3
|
6.497E-2
|
1.675E-1
|
2
|
215
|
|
13
|
hsa-miR-362-3p:PITA
|
hsa-miR-362-3p:PITA TOP
|
PITA
|
3.905E-4
|
9.785E-3
|
6.497E-2
|
1.675E-1
|
2
|
215
|
|
14
|
GGCAGCT,MIR-22:MSigDB
|
GGCAGCT,MIR-22:MSigDB
|
MSigDB
|
4.015E-4
|
9.785E-3
|
6.497E-2
|
1.722E-1
|
2
|
218
|
|
15
|
hsa-miR-24:PITA
|
hsa-miR-24:PITA TOP
|
PITA
|
4.200E-4
|
9.785E-3
|
6.497E-2
|
1.802E-1
|
2
|
223
|
|
16
|
hsa-miR-297:PITA
|
hsa-miR-297:PITA TOP
|
PITA
|
4.621E-4
|
9.785E-3
|
6.497E-2
|
1.983E-1
|
2
|
234
|
|
17
|
GTACTGT,MIR-101:MSigDB
|
GTACTGT,MIR-101:MSigDB
|
MSigDB
|
4.941E-4
|
9.785E-3
|
6.497E-2
|
2.120E-1
|
2
|
242
|
|
18
|
hsa-miR-22:PITA
|
hsa-miR-22:PITA TOP
|
PITA
|
5.482E-4
|
9.785E-3
|
6.497E-2
|
2.352E-1
|
2
|
255
|
|
19
|
hsa-miR-512-3p:PITA
|
hsa-miR-512-3p:PITA TOP
|
PITA
|
5.961E-4
|
9.785E-3
|
6.497E-2
|
2.557E-1
|
2
|
266
|
|
20
|
hsa-miR-302f:PITA
|
hsa-miR-302f:PITA TOP
|
PITA
|
6.276E-4
|
9.785E-3
|
6.497E-2
|
2.692E-1
|
2
|
273
|
|
21
|
hsa-miR-1207-3p:PITA
|
hsa-miR-1207-3p:PITA TOP
|
PITA
|
6.414E-4
|
9.785E-3
|
6.497E-2
|
2.751E-1
|
2
|
276
|
|
22
|
hsa-miR-140-5p:PITA
|
hsa-miR-140-5p:PITA TOP
|
PITA
|
6.740E-4
|
9.785E-3
|
6.497E-2
|
2.892E-1
|
2
|
283
|
|
23
|
hsa-miR-1181:PITA
|
hsa-miR-1181:PITA TOP
|
PITA
|
6.920E-4
|
9.785E-3
|
6.497E-2
|
2.968E-1
|
1
|
5
|
|
24
|
hsa-miR-342-3p:Functional MTI
|
Functional MTI
|
miRTarbase
|
7.768E-4
|
9.785E-3
|
6.497E-2
|
3.332E-1
|
2
|
304
|
|
25
|
AGCACTT,MIR-302A:MSigDB
|
AGCACTT,MIR-302A:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
26
|
AGCACTT,MIR-520E:MSigDB
|
AGCACTT,MIR-520E:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
27
|
AGCACTT,MIR-373:MSigDB
|
AGCACTT,MIR-373:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
28
|
AGCACTT,MIR-302D:MSigDB
|
AGCACTT,MIR-302D:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
29
|
AGCACTT,MIR-520C:MSigDB
|
AGCACTT,MIR-520C:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
30
|
AGCACTT,MIR-526B:MSigDB
|
AGCACTT,MIR-526B:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
31
|
AGCACTT,MIR-302C:MSigDB
|
AGCACTT,MIR-302C:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
32
|
AGCACTT,MIR-520B:MSigDB
|
AGCACTT,MIR-520B:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
33
|
AGCACTT,MIR-93:MSigDB
|
AGCACTT,MIR-93:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
34
|
AGCACTT,MIR-520A:MSigDB
|
AGCACTT,MIR-520A:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
35
|
AGCACTT,MIR-372:MSigDB
|
AGCACTT,MIR-372:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
36
|
AGCACTT,MIR-302B:MSigDB
|
AGCACTT,MIR-302B:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
37
|
AGCACTT,MIR-520D:MSigDB
|
AGCACTT,MIR-520D:MSigDB
|
MSigDB
|
8.439E-4
|
9.785E-3
|
6.497E-2
|
3.620E-1
|
2
|
317
|
|
38
|
hsa-miR-937:PITA
|
hsa-miR-937:PITA TOP
|
PITA
|
9.686E-4
|
1.094E-2
|
7.261E-2
|
4.155E-1
|
1
|
7
|
|
39
|
hsa-miR-4283:mirSVR highEffct
|
hsa-miR-4283:mirSVR nonconserved highEffect-0.5
|
MicroRNA.org
|
1.038E-3
|
1.142E-2
|
7.583E-2
|
4.454E-1
|
2
|
352
|
|
40
|
hsa-miR-1:PITA
|
hsa-miR-1:PITA TOP
|
PITA
|
1.152E-3
|
1.183E-2
|
7.854E-2
|
4.941E-1
|
2
|
371
|
|
41
|
hsa-miR-206:PITA
|
hsa-miR-206:PITA TOP
|
PITA
|
1.152E-3
|
1.183E-2
|
7.854E-2
|
4.941E-1
|
2
|
371
|
|
42
|
hsa-miR-613:PITA
|
hsa-miR-613:PITA TOP
|
PITA
|
1.158E-3
|
1.183E-2
|
7.854E-2
|
4.968E-1
|
2
|
372
|
|
43
|
hsa-miR-328:mirSVR highEffct
|
hsa-miR-328:mirSVR conserved highEffect-0.5
|
MicroRNA.org
|
1.356E-3
|
1.353E-2
|
8.984E-2
|
5.818E-1
|
2
|
403
|
|
44
|
hsa-miR-587:PITA
|
hsa-miR-587:PITA TOP
|
PITA
|
1.437E-3
|
1.401E-2
|
9.303E-2
|
6.165E-1
|
2
|
415
|
|
45
|
hsa-miR-646:PITA
|
hsa-miR-646:PITA TOP
|
PITA
|
1.591E-3
|
1.517E-2
|
1.007E-1
|
6.825E-1
|
2
|
437
|
|
46
|
hsa-miR-22-3p:TargetScan
|
hsa-miR-22-3p
|
TargetScan
|
1.656E-3
|
1.525E-2
|
1.013E-1
|
7.105E-1
|
2
|
446
|
|
47
|
hsa-miR-662:mirSVR lowEffct
|
hsa-miR-662:mirSVR nonconserved lowEffect-0.1-0.5
|
MicroRNA.org
|
1.671E-3
|
1.525E-2
|
1.013E-1
|
7.168E-1
|
2
|
448
|
|
48
|
GCGCCTT,MIR-524:MSigDB
|
GCGCCTT,MIR-524:MSigDB
|
MSigDB
|
1.936E-3
|
1.598E-2
|
1.061E-1
|
8.307E-1
|
1
|
14
|
|
49
|
GCGCCTT,MIR-525:MSigDB
|
GCGCCTT,MIR-525:MSigDB
|
MSigDB
|
1.936E-3
|
1.598E-2
|
1.061E-1
|
8.307E-1
|
1
|
14
|
|
50
|
TTTGCAC,MIR-19A:MSigDB
|
TTTGCAC,MIR-19A:MSigDB
|
MSigDB
|
1.937E-3
|
1.598E-2
|
1.061E-1
|
8.311E-1
|
2
|
483
|
Show 45 more annotations
|
17: Drug [Display Chart]
10 input genes in category / 4099 annotations before applied cutoff / 22841 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
CID004629889
|
AC1NDQBC
|
Stitch
|
2.063E-5
|
1.413E-2
|
1.257E-1
|
8.458E-2
|
2
|
16
|
|
2
|
CID000076883
|
l-yl
|
Stitch
|
2.938E-5
|
1.413E-2
|
1.257E-1
|
1.204E-1
|
2
|
19
|
|
3
|
5362 UP
|
Nilutamide [63612-50-0]; Up 200; 12.6uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Up
|
6.929E-5
|
1.413E-2
|
1.257E-1
|
2.840E-1
|
3
|
194
|
|
4
|
2025 UP
|
Chlorhexidine [55-56-1]; Up 200; 8uM; HL60; HG-U133A
|
Broad Institute CMAP Up
|
7.035E-5
|
1.413E-2
|
1.257E-1
|
2.884E-1
|
3
|
195
|
|
5
|
1815 UP
|
Sulindac [38194-50-2]; Up 200; 11.2uM; PC3; HT HG-U133A
|
Broad Institute CMAP Up
|
7.035E-5
|
1.413E-2
|
1.257E-1
|
2.884E-1
|
3
|
195
|
|
6
|
3719 DN
|
Bromopride [4093-35-0]; Down 200; 11.6uM; PC3; HT HG-U133A
|
Broad Institute CMAP Down
|
7.035E-5
|
1.413E-2
|
1.257E-1
|
2.884E-1
|
3
|
195
|
|
7
|
4130 DN
|
Pheniramine maleate [132-20-7]; Down 200; 11.2uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Down
|
7.143E-5
|
1.413E-2
|
1.257E-1
|
2.928E-1
|
3
|
196
|
|
8
|
4773 UP
|
Spectinomycin dihydrochloride [21736-83-4]; Up 200; 9.8uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Up
|
7.143E-5
|
1.413E-2
|
1.257E-1
|
2.928E-1
|
3
|
196
|
|
9
|
4166 DN
|
Solanine alpha [20562-02-1]; Down 200; 4.6uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Down
|
7.143E-5
|
1.413E-2
|
1.257E-1
|
2.928E-1
|
3
|
196
|
|
10
|
6232 UP
|
Thiethylperazine malate [52239-63-1]; Up 200; 6uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Up
|
7.143E-5
|
1.413E-2
|
1.257E-1
|
2.928E-1
|
3
|
196
|
|
11
|
503 DN
|
indomethacin, USP; Down 200; 100uM; SKMEL5; HG-U133A
|
Broad Institute CMAP Down
|
7.252E-5
|
1.413E-2
|
1.257E-1
|
2.972E-1
|
3
|
197
|
|
12
|
CID000007870
|
2-methyl-2,4-pentanediol
|
Stitch
|
7.252E-5
|
1.413E-2
|
1.257E-1
|
2.972E-1
|
3
|
197
|
|
13
|
6785 UP
|
Methylprednisolone, 6-alpha [83-43-2]; Up 200; 10.6uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Up
|
7.252E-5
|
1.413E-2
|
1.257E-1
|
2.972E-1
|
3
|
197
|
|
14
|
5785 DN
|
Dorzolamide hydrochloride [130693-82-2]; Down 200; 11uM; PC3; HT HG-U133A
|
Broad Institute CMAP Down
|
7.252E-5
|
1.413E-2
|
1.257E-1
|
2.972E-1
|
3
|
197
|
|
15
|
1710 UP
|
Piracetam [7491-74-9]; Up 200; 28.2uM; HL60; HG-U133A
|
Broad Institute CMAP Up
|
7.362E-5
|
1.413E-2
|
1.257E-1
|
3.018E-1
|
3
|
198
|
|
16
|
4397 UP
|
Bicuculline (+) [485-49-4]; Up 200; 10.8uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Up
|
7.362E-5
|
1.413E-2
|
1.257E-1
|
3.018E-1
|
3
|
198
|
|
17
|
2117 DN
|
Aceclofenac [89796-99-6]; Down 200; 11.2uM; PC3; HT HG-U133A
|
Broad Institute CMAP Down
|
7.362E-5
|
1.413E-2
|
1.257E-1
|
3.018E-1
|
3
|
198
|
|
18
|
1907 UP
|
Captopril [62571-86-2]; Up 200; 17.2uM; PC3; HG-U133A
|
Broad Institute CMAP Up
|
7.362E-5
|
1.413E-2
|
1.257E-1
|
3.018E-1
|
3
|
198
|
|
19
|
1326 DN
|
Muramic acid, N-acetyl [10597-89-4]; Down 200; 13.6uM; HL60; HT HG-U133A
|
Broad Institute CMAP Down
|
7.362E-5
|
1.413E-2
|
1.257E-1
|
3.018E-1
|
3
|
198
|
|
20
|
5798 DN
|
Sulfamethizole [144-82-1]; Down 200; 14.8uM; PC3; HT HG-U133A
|
Broad Institute CMAP Down
|
7.473E-5
|
1.413E-2
|
1.257E-1
|
3.063E-1
|
3
|
199
|
|
21
|
3207 UP
|
Debrisoquin sulfate [581-88-4]; Up 200; 9uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Up
|
7.473E-5
|
1.413E-2
|
1.257E-1
|
3.063E-1
|
3
|
199
|
|
22
|
5781 DN
|
Spironolactone [52-01-7]; Down 200; 9.6uM; PC3; HT HG-U133A
|
Broad Institute CMAP Down
|
7.585E-5
|
1.413E-2
|
1.257E-1
|
3.109E-1
|
3
|
200
|
|
23
|
CID004629888
|
AC1NDQB9
|
Stitch
|
9.043E-5
|
1.612E-2
|
1.434E-1
|
3.707E-1
|
2
|
33
|
|
24
|
ctd:C038044
|
baicalin
|
CTD
|
1.078E-4
|
1.842E-2
|
1.638E-1
|
4.420E-1
|
2
|
36
|
|
25
|
CID000069736
|
6-hydroxymethylpterin
|
Stitch
|
1.140E-4
|
1.869E-2
|
1.662E-1
|
4.671E-1
|
2
|
37
|
|
26
|
ctd:C419410
|
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester
|
CTD
|
1.616E-4
|
2.526E-2
|
2.247E-1
|
6.624E-1
|
2
|
44
|
|
27
|
CID000012620
|
Tadenan
|
Stitch
|
1.767E-4
|
2.526E-2
|
2.247E-1
|
7.244E-1
|
2
|
46
|
|
28
|
CID000032744
|
polyinosinic-polycytidylic acid
|
Stitch
|
2.299E-4
|
2.526E-2
|
2.247E-1
|
9.422E-1
|
3
|
291
|
|
29
|
CID000003154
|
Cosopt
|
Stitch
|
3.662E-4
|
2.526E-2
|
2.247E-1
|
1.000E0
|
3
|
341
|
|
30
|
ctd:C523462
|
benzyloxycarbonyl-leucyl-leucyl-norleucinal
|
CTD
|
4.378E-4
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
1
|
|
31
|
CID000217246
|
clenproperol
|
Stitch
|
4.378E-4
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
1
|
|
32
|
CID011287728
|
4-bromo-2,5-dimethoxy-phenol
|
Stitch
|
4.378E-4
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
1
|
|
33
|
CID000062389
|
benzyladenine
|
Stitch
|
4.960E-4
|
2.526E-2
|
2.247E-1
|
1.000E0
|
2
|
77
|
|
34
|
CID000061258
|
lead stearate
|
Stitch
|
5.900E-4
|
2.526E-2
|
2.247E-1
|
1.000E0
|
2
|
84
|
|
35
|
ctd:C006680
|
baicalein
|
CTD
|
6.327E-4
|
2.526E-2
|
2.247E-1
|
1.000E0
|
2
|
87
|
|
36
|
CID005326798
|
DB08181
|
Stitch
|
7.225E-4
|
2.526E-2
|
2.247E-1
|
1.000E0
|
2
|
93
|
|
37
|
CID000094426
|
1-piperonylpiperazine
|
Stitch
|
8.754E-4
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
2
|
|
38
|
CID000004171
|
metoprolol
|
Stitch
|
9.195E-4
|
2.526E-2
|
2.247E-1
|
1.000E0
|
2
|
105
|
|
39
|
CID000162573
|
polyd(CT
|
Stitch
|
1.313E-3
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
3
|
|
40
|
CID000016022
|
2,5-dichloro-4-bromophenol
|
Stitch
|
1.313E-3
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
3
|
|
41
|
CID000014992
|
mollutox
|
Stitch
|
1.313E-3
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
3
|
|
42
|
ctd:C484278
|
N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide
|
CTD
|
1.313E-3
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
3
|
|
43
|
CID000130705
|
9-OH-B220
|
Stitch
|
1.341E-3
|
2.526E-2
|
2.247E-1
|
1.000E0
|
2
|
127
|
|
44
|
CID003035525
|
F-IPP
|
Stitch
|
1.750E-3
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
4
|
|
45
|
CID000467306
|
Rhodisin
|
Stitch
|
1.750E-3
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
4
|
|
46
|
CID000074083
|
9-fluorenone-1-carboxylic acid
|
Stitch
|
1.750E-3
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
4
|
|
47
|
CID000146151
|
olivoretin
|
Stitch
|
1.750E-3
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
4
|
|
48
|
CID000173475
|
difluoromethoxydifluoroacetic acid
|
Stitch
|
1.750E-3
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
4
|
|
49
|
CID000003351
|
fipexide
|
Stitch
|
2.187E-3
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
5
|
|
50
|
CID000010392
|
phenylcarbamic acid
|
Stitch
|
2.187E-3
|
2.526E-2
|
2.247E-1
|
1.000E0
|
1
|
5
|
Show 45 more annotations
|
18: Disease [Display Chart]
9 input genes in category / 202 annotations before applied cutoff / 16205 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
C1961099
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
DisGeNET Curated
|
3.821E-5
|
7.717E-3
|
4.544E-2
|
7.717E-3
|
4
|
391
|
|
2
|
C0887833
|
Carcinoma, Pancreatic Ductal
|
DisGeNET Curated
|
2.563E-4
|
2.244E-2
|
1.321E-1
|
5.177E-2
|
2
|
44
|
|
3
|
OMIN:606394
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 6; MODY6
|
OMIM
|
5.554E-4
|
2.244E-2
|
1.321E-1
|
1.122E-1
|
1
|
1
|
|
4
|
C1853371
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 6 (disorder)
|
DisGeNET Curated
|
5.554E-4
|
2.244E-2
|
1.321E-1
|
1.122E-1
|
1
|
1
|
|
5
|
cv:C1853371
|
Maturity-onset diabetes of the young, type 6
|
Clinical Variations
|
5.554E-4
|
2.244E-2
|
1.321E-1
|
1.122E-1
|
1
|
1
|
|
6
|
C1879677
|
Alcohol Toxicity
|
DisGeNET Curated
|
1.110E-3
|
2.403E-2
|
1.415E-1
|
2.243E-1
|
1
|
2
|
|
7
|
C1704272
|
Benign Prostatic Hyperplasia
|
DisGeNET BeFree
|
1.240E-3
|
2.403E-2
|
1.415E-1
|
2.504E-1
|
3
|
414
|
|
8
|
C0334583
|
Pilocytic Astrocytoma
|
DisGeNET Curated
|
1.453E-3
|
2.403E-2
|
1.415E-1
|
2.936E-1
|
2
|
105
|
|
9
|
C0152021
|
Congenital heart disease
|
DisGeNET Curated
|
1.481E-3
|
2.403E-2
|
1.415E-1
|
2.991E-1
|
2
|
106
|
|
10
|
C0007129
|
Merkel cell carcinoma
|
DisGeNET Curated
|
1.509E-3
|
2.403E-2
|
1.415E-1
|
3.047E-1
|
2
|
107
|
|
11
|
C0206663
|
Neuroectodermal Tumor, Primitive
|
DisGeNET Curated
|
1.651E-3
|
2.403E-2
|
1.415E-1
|
3.335E-1
|
2
|
112
|
|
12
|
C0205695
|
Carcinoid, Goblet Cell
|
DisGeNET BeFree
|
1.665E-3
|
2.403E-2
|
1.415E-1
|
3.364E-1
|
1
|
3
|
|
13
|
C0344787
|
Complete atrioventricular septal defect
|
DisGeNET Curated
|
1.665E-3
|
2.403E-2
|
1.415E-1
|
3.364E-1
|
1
|
3
|
|
14
|
C1370507
|
Cerebellar Liponeurocytoma
|
DisGeNET BeFree
|
1.665E-3
|
2.403E-2
|
1.415E-1
|
3.364E-1
|
1
|
3
|
|
15
|
C0085669
|
Acute leukemia
|
DisGeNET Curated
|
2.026E-3
|
2.491E-2
|
1.467E-1
|
4.093E-1
|
3
|
491
|
|
16
|
C1970431
|
PITT-HOPKINS SYNDROME
|
DisGeNET Curated
|
2.220E-3
|
2.491E-2
|
1.467E-1
|
4.484E-1
|
1
|
4
|
|
17
|
C0024904
|
Mastoiditis
|
DisGeNET Curated
|
2.220E-3
|
2.491E-2
|
1.467E-1
|
4.484E-1
|
1
|
4
|
|
18
|
C0221215
|
Common atrioventricular canal
|
DisGeNET Curated
|
2.220E-3
|
2.491E-2
|
1.467E-1
|
4.484E-1
|
1
|
4
|
|
19
|
C2607914
|
Allergic rhinitis (disorder)
|
DisGeNET Curated
|
2.673E-3
|
2.802E-2
|
1.650E-1
|
5.400E-1
|
2
|
143
|
|
20
|
C0041364
|
Tumor Lysis Syndrome
|
DisGeNET Curated
|
2.774E-3
|
2.802E-2
|
1.650E-1
|
5.604E-1
|
1
|
5
|
|
21
|
C0588006
|
Mild depression
|
DisGeNET Curated
|
3.328E-3
|
3.201E-2
|
1.885E-1
|
6.723E-1
|
1
|
6
|
|
22
|
C0267990
|
Adult-onset obesity
|
DisGeNET BeFree
|
3.882E-3
|
3.564E-2
|
2.099E-1
|
7.842E-1
|
1
|
7
|
|
23
|
C3152144
|
AGAMMAGLOBULINEMIA 1, AUTOSOMAL RECESSIVE
|
DisGeNET Curated
|
4.435E-3
|
3.584E-2
|
2.110E-1
|
8.960E-1
|
1
|
8
|
|
24
|
C0149779
|
Somatization
|
DisGeNET BeFree
|
4.435E-3
|
3.584E-2
|
2.110E-1
|
8.960E-1
|
1
|
8
|
|
25
|
C0233697
|
Obsessions
|
DisGeNET BeFree
|
4.435E-3
|
3.584E-2
|
2.110E-1
|
8.960E-1
|
1
|
8
|
|
26
|
C0747249
|
Paranoid ideation
|
DisGeNET BeFree
|
4.989E-3
|
3.682E-2
|
2.168E-1
|
1.000E0
|
1
|
9
|
|
27
|
C0687131
|
Psychoticism
|
DisGeNET BeFree
|
4.989E-3
|
3.682E-2
|
2.168E-1
|
1.000E0
|
1
|
9
|
|
28
|
C0553665
|
Skin endocrine disorder
|
DisGeNET BeFree
|
5.104E-3
|
3.682E-2
|
2.168E-1
|
1.000E0
|
2
|
199
|
|
29
|
C0206637
|
Chondrosarcoma, Mesenchymal
|
DisGeNET Curated
|
5.542E-3
|
3.731E-2
|
2.197E-1
|
1.000E0
|
1
|
10
|
|
30
|
C0265220
|
Pallister-Hall syndrome
|
DisGeNET Curated
|
5.542E-3
|
3.731E-2
|
2.197E-1
|
1.000E0
|
1
|
10
|
|
31
|
C0003504
|
Aortic Valve Insufficiency
|
DisGeNET Curated
|
7.581E-3
|
4.940E-2
|
2.909E-1
|
1.000E0
|
2
|
244
|
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