Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc407_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 47 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030151 molybdenum ion binding 1.206E-6 5.666E-5 2.514E-4 5.666E-5 2 5
2 GO:0008265 Mo-molybdopterin cofactor sulfurase activity 3.751E-4 3.526E-3 1.565E-2 1.763E-2 1 1
3 GO:0061598 molybdopterin adenylyltransferase activity 3.751E-4 3.526E-3 1.565E-2 1.763E-2 1 1
4 GO:0061599 molybdopterin molybdotransferase activity 3.751E-4 3.526E-3 1.565E-2 1.763E-2 1 1
5 GO:0008482 sulfite oxidase activity 3.751E-4 3.526E-3 1.565E-2 1.763E-2 1 1
6 GO:0031750 D3 dopamine receptor binding 1.500E-3 1.174E-2
5.212E-2
7.049E-2
 1 4
7 GO:0043546 molybdopterin cofactor binding 1.874E-3 1.174E-2
5.212E-2
8.810E-2
 1 5
8 GO:0016933 extracellularly glycine-gated ion channel activity 2.249E-3 1.174E-2
5.212E-2
1.057E-1
 1 6
9 GO:0016934 extracellularly glycine-gated chloride channel activity 2.249E-3 1.174E-2
5.212E-2
1.057E-1
 1 6
10 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2.623E-3 1.233E-2
5.472E-2
1.233E-1
 1 7
11 GO:0005237 inhibitory extracellular ligand-gated ion channel activity 2.998E-3 1.281E-2
5.684E-2
1.409E-1
 1 8
12 GO:0048037 cofactor binding 4.389E-3 1.719E-2
7.629E-2
2.063E-1
 2 277
13 GO:0030676 Rac guanyl-nucleotide exchange factor activity 4.867E-3 1.760E-2
7.809E-2
2.288E-1
 1 13
14 GO:0016594 glycine binding 5.614E-3 1.885E-2
8.364E-2
2.639E-1
 1 15
15 GO:0050780 dopamine receptor binding 8.225E-3 2.577E-2
1.144E-1
3.866E-1
 1 22
16 GO:0070566 adenylyltransferase activity 1.157E-2 3.399E-2
1.509E-1
5.439E-1
 1 31
Show 11 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 132 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0097112 gamma-aminobutyric acid receptor clustering 7.264E-7 3.994E-5 2.182E-4 9.588E-5 2 4
2 GO:0019720 Mo-molybdopterin cofactor metabolic process 1.815E-6 3.994E-5 2.182E-4 2.396E-4 2 6
3 GO:0051189 prosthetic group metabolic process 1.815E-6 3.994E-5 2.182E-4 2.396E-4 2 6
4 GO:0006777 Mo-molybdopterin cofactor biosynthetic process 1.815E-6 3.994E-5 2.182E-4 2.396E-4 2 6
5 GO:0043545 molybdopterin cofactor metabolic process 1.815E-6 3.994E-5 2.182E-4 2.396E-4 2 6
6 GO:0032324 molybdopterin cofactor biosynthetic process 1.815E-6 3.994E-5 2.182E-4 2.396E-4 2 6
7 GO:0072578 neurotransmitter-gated ion channel clustering 6.650E-6 1.254E-4 6.852E-4 8.778E-4 2 11
8 GO:0046039 GTP metabolic process 3.618E-5 5.970E-4 3.262E-3 4.776E-3 2 25
9 GO:0001941 postsynaptic membrane organization 6.755E-5 9.908E-4 5.413E-3 8.917E-3 2 34
10 GO:0050808 synapse organization 8.828E-5 1.165E-3 6.367E-3 1.165E-2 3 258
11 GO:1901068 guanosine-containing compound metabolic process 1.355E-4 1.626E-3 8.883E-3 1.788E-2 2 48
12 GO:0043113 receptor clustering 1.654E-4 1.819E-3 9.939E-3 2.183E-2 2 53
13 GO:0046847 filopodium assembly 2.193E-4 2.227E-3 1.217E-2 2.895E-2 2 61
14 GO:0042128 nitrate assimilation 3.759E-4 2.919E-3 1.595E-2 4.962E-2 1 1
15 GO:0042040 metal incorporation into metallo-molybdopterin complex 3.759E-4 2.919E-3 1.595E-2 4.962E-2 1 1
16 GO:0018315 molybdenum incorporation into molybdenum-molybdopterin complex 3.759E-4 2.919E-3 1.595E-2 4.962E-2 1 1
17 GO:0072579 glycine receptor clustering 3.759E-4 2.919E-3 1.595E-2 4.962E-2 1 1
18 GO:0009108 coenzyme biosynthetic process 1.117E-3 7.086E-3 3.871E-2
1.475E-1
 2 138
19 GO:0051668 localization within membrane 1.117E-3 7.086E-3 3.871E-2
1.475E-1
 2 138
20 GO:0060160 negative regulation of dopamine receptor signaling pathway 1.127E-3 7.086E-3 3.871E-2
1.488E-1
 1 3
21 GO:0007529 establishment of synaptic specificity at neuromuscular junction 1.127E-3 7.086E-3 3.871E-2
1.488E-1
 1 3
22 GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase 1.503E-3 8.265E-3 4.516E-2
1.984E-1
 1 4
23 GO:0019418 sulfide oxidation 1.503E-3 8.265E-3 4.516E-2
1.984E-1
 1 4
24 GO:0042126 nitrate metabolic process 1.503E-3 8.265E-3 4.516E-2
1.984E-1
 1 4
25 GO:0051188 cofactor biosynthetic process 1.911E-3 1.009E-2
5.512E-2
2.522E-1
 2 181
26 GO:0060159 regulation of dopamine receptor signaling pathway 3.004E-3 1.468E-2
8.023E-2
3.965E-1
 1 8
27 GO:0060012 synaptic transmission, glycinergic 3.004E-3 1.468E-2
8.023E-2
3.965E-1
 1 8
28 GO:0009205 purine ribonucleoside triphosphate metabolic process 3.982E-3 1.798E-2
9.822E-2
5.256E-1
 2 263
29 GO:0060013 righting reflex 4.128E-3 1.798E-2
9.822E-2
5.449E-1
 1 11
30 GO:0009199 ribonucleoside triphosphate metabolic process 4.192E-3 1.798E-2
9.822E-2
5.533E-1
 2 270
31 GO:0009144 purine nucleoside triphosphate metabolic process 4.222E-3 1.798E-2
9.822E-2
5.573E-1
 2 271
32 GO:0010976 positive regulation of neuron projection development 4.690E-3 1.935E-2
1.057E-1
6.191E-1
 2 286
33 GO:0009141 nucleoside triphosphate metabolic process 4.983E-3 1.993E-2
1.089E-1
6.577E-1
 2 295
34 GO:0071257 cellular response to electrical stimulus 6.000E-3 2.329E-2
1.273E-1
7.919E-1
 1 16
35 GO:0006732 coenzyme metabolic process 6.308E-3 2.337E-2
1.277E-1
8.327E-1
 2 333
36 GO:0071941 nitrogen cycle metabolic process 6.373E-3 2.337E-2
1.277E-1
8.413E-1
 1 17
37 GO:0046128 purine ribonucleoside metabolic process 7.378E-3 2.578E-2
1.409E-1
9.739E-1
 2 361
38 GO:0042278 purine nucleoside metabolic process 7.497E-3 2.578E-2
1.409E-1
9.897E-1
 2 364
39 GO:0031346 positive regulation of cell projection organization 7.618E-3 2.578E-2
1.409E-1
1.000E0
 2 367
40 GO:0045666 positive regulation of neuron differentiation 7.983E-3 2.635E-2
1.439E-1
1.000E0
 2 376
41 GO:0060074 synapse maturation 8.241E-3 2.653E-2
1.450E-1
1.000E0
 1 22
42 GO:0009119 ribonucleoside metabolic process 8.611E-3 2.706E-2
1.479E-1
1.000E0
 2 391
43 GO:0060004 reflex 8.988E-3 2.746E-2
1.500E-1
1.000E0
 1 24
44 GO:0007194 negative regulation of adenylate cyclase activity 9.361E-3 2.746E-2
1.500E-1
1.000E0
 1 25
45 GO:0051186 cofactor metabolic process 9.392E-3 2.746E-2
1.500E-1
1.000E0
 2 409
46 GO:0009116 nucleoside metabolic process 9.570E-3 2.746E-2
1.500E-1
1.000E0
 2 413
47 GO:0031280 negative regulation of cyclase activity 1.011E-2 2.838E-2
1.551E-1
1.000E0
 1 27
48 GO:1901657 glycosyl compound metabolic process 1.058E-2 2.862E-2
1.564E-1
1.000E0
 2 435
49 GO:0030031 cell projection assembly 1.062E-2 2.862E-2
1.564E-1
1.000E0
 2 436
50 GO:0051350 negative regulation of lyase activity 1.085E-2 2.865E-2
1.565E-1
1.000E0
 1 29
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 40 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0097060 synaptic membrane 1.975E-6 7.899E-5 3.380E-4 7.899E-5 4 298
2 GO:0098794 postsynapse 1.005E-5 2.010E-4 8.601E-4 4.021E-4 4 449
3 GO:0045211 postsynaptic membrane 5.485E-5 7.314E-4 3.129E-3 2.194E-3 3 225
4 GO:0030175 filopodium 5.852E-4 5.852E-3 2.504E-2 2.341E-2 2 102
5 GO:0016935 glycine-gated chloride channel complex 7.344E-4 5.875E-3 2.514E-2 2.937E-2 1 2
6 GO:0031256 leading edge membrane 1.259E-3 6.546E-3 2.801E-2
5.035E-2
 2 150
7 GO:0043197 dendritic spine 1.276E-3 6.546E-3 2.801E-2
5.102E-2
 2 151
8 GO:0044309 neuron spine 1.309E-3 6.546E-3 2.801E-2
5.237E-2
 2 153
9 GO:0098858 actin-based cell projection 2.310E-3 1.027E-2 4.394E-2
9.242E-2
 2 204
10 GO:0014069 postsynaptic density 2.975E-3 1.082E-2 4.629E-2
1.190E-1
 2 232
11 GO:0099572 postsynaptic specialization 2.975E-3 1.082E-2 4.629E-2
1.190E-1
 2 232
12 GO:0060076 excitatory synapse 3.499E-3 1.128E-2 4.828E-2
1.400E-1
 2 252
13 GO:0032591 dendritic spine membrane 3.667E-3 1.128E-2 4.828E-2
1.467E-1
 1 10
14 GO:0043194 axon initial segment 4.765E-3 1.361E-2
5.825E-2
1.906E-1
 1 13
15 GO:0031253 cell projection membrane 5.995E-3 1.599E-2
6.840E-2
2.398E-1
 2 332
16 GO:0031527 filopodium membrane 6.958E-3 1.627E-2
6.963E-2
2.783E-1
 1 19
17 GO:0016327 apicolateral plasma membrane 6.958E-3 1.627E-2
6.963E-2
2.783E-1
 1 19
18 GO:0060077 inhibitory synapse 7.323E-3 1.627E-2
6.963E-2
2.929E-1
 1 20
19 GO:0031252 cell leading edge 8.151E-3 1.716E-2
7.342E-2
3.261E-1
 2 389
20 GO:0032590 dendrite membrane 1.133E-2 2.266E-2
9.696E-2
4.532E-1
 1 31
21 GO:0032589 neuron projection membrane 1.786E-2 3.313E-2
1.417E-1
7.144E-1
 1 49
22 GO:0034707 chloride channel complex 1.822E-2 3.313E-2
1.417E-1
7.288E-1
 1 50
23 GO:0044304 main axon 2.687E-2 4.672E-2
1.999E-1
1.000E0
 1 74
24 GO:0005758 mitochondrial intermembrane space 2.866E-2 4.776E-2
2.044E-1
1.000E0
 1 79
25 GO:0032587 ruffle membrane 3.045E-2 4.872E-2
2.084E-1
1.000E0
 1 84
Show 20 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 232 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004369 Decreased purine level 2.432E-5 5.643E-3 3.400E-2 5.643E-3 2 10
2 HP:0002267 Exaggerated startle response 1.024E-4 1.188E-2
7.158E-2
 2.376E-2 2 20

5: Mouse Phenotype [Display Chart] 4 input genes in category / 141 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 7 input genes in category / 85 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR005110 MoeA linker/N InterPro 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
2 2.60.40.650 - Gene3D 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
3 2.40.340.10 - Gene3D 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
4 IPR008060 Glycine rcpt B InterPro 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
5 PF00174 Oxidored molyb Pfam 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
6 3.90.420.10 - Gene3D 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
7 IPR008335 Mopterin OxRdtase euk InterPro 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
8 IPR008284 MoCF biosynth CS InterPro 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
9 PF03454 MoeA C Pfam 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
10 PF03453 MoeA N Pfam 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
11 PS01079 MOCF BIOSYNTHESIS 2 PROSITE 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
12 PF03404 Mo-co dimer Pfam 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
13 IPR005111 MoeA C domain IV InterPro 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
14 PS01078 MOCF BIOSYNTHESIS 1 PROSITE 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
15 IPR005066 MoCF OxRdtse dimer InterPro 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
16 IPR028886 MoCo sulfurase InterPro 3.736E-4 1.985E-3 9.976E-3 3.176E-2 1 1
17 3.40.980.10 - Gene3D 7.471E-4 3.175E-3 1.596E-2
6.351E-2
 1 2
18 IPR001453 MoaB/Mog dom InterPro 7.471E-4 3.175E-3 1.596E-2
6.351E-2
 1 2
19 SM00852 MoCF biosynth SMART 7.471E-4 3.175E-3 1.596E-2
6.351E-2
 1 2
20 PF00994 MoCF biosynth Pfam 7.471E-4 3.175E-3 1.596E-2
6.351E-2
 1 2
21 PS00559 MOLYBDOPTERIN EUK PROSITE 1.121E-3 3.175E-3 1.596E-2
9.525E-2
 1 3
22 PF03285 Paralemmin Pfam 1.121E-3 3.175E-3 1.596E-2
9.525E-2
 1 3
23 IPR004965 Paralemmin InterPro 1.121E-3 3.175E-3 1.596E-2
9.525E-2
 1 3
24 IPR022407 OxRdtase Mopterin BS InterPro 1.121E-3 3.175E-3 1.596E-2
9.525E-2
 1 3
25 IPR005303 MOSC N InterPro 1.121E-3 3.175E-3 1.596E-2
9.525E-2
 1 3
26 IPR000572 OxRdtase Mopterin-bd dom InterPro 1.121E-3 3.175E-3 1.596E-2
9.525E-2
 1 3
27 PF03473 MOSC Pfam 1.121E-3 3.175E-3 1.596E-2
9.525E-2
 1 3
28 PF03476 MOSC N Pfam 1.121E-3 3.175E-3 1.596E-2
9.525E-2
 1 3
29 PS51340 MOSC PROSITE 1.121E-3 3.175E-3 1.596E-2
9.525E-2
 1 3
30 IPR005302 MoCF Sase C InterPro 1.121E-3 3.175E-3 1.596E-2
9.525E-2
 1 3
31 PS00595 AA TRANSFER CLASS 5 PROSITE 1.867E-3 4.809E-3 2.417E-2
1.587E-1
 1 5
32 IPR011037 Pyrv Knase-like insert dom InterPro 1.867E-3 4.809E-3 2.417E-2
1.587E-1
 1 5
33 IPR018506 Cyt B5 heme-BS InterPro 1.867E-3 4.809E-3 2.417E-2
1.587E-1
 1 5
34 PF00266 Aminotran 5 Pfam 2.240E-3 5.440E-3 2.734E-2
1.904E-1
 1 6
35 IPR000192 Aminotrans V dom InterPro 2.240E-3 5.440E-3 2.734E-2
1.904E-1
 1 6
36 PS00191 CYTOCHROME B5 1 PROSITE 4.848E-3 1.082E-2
5.439E-2
4.121E-1
 1 13
37 PS50255 CYTOCHROME B5 2 PROSITE 4.848E-3 1.082E-2
5.439E-2
4.121E-1
 1 13
38 IPR001199 Cyt B5-like heme/steroid-bd InterPro 5.220E-3 1.082E-2
5.439E-2
4.437E-1
 1 14
39 SM01117 Cyt-b5 SMART 5.220E-3 1.082E-2
5.439E-2
4.437E-1
 1 14
40 3.10.120.10 - Gene3D 5.220E-3 1.082E-2
5.439E-2
4.437E-1
 1 14
41 PF00173 Cyt-b5 Pfam 5.220E-3 1.082E-2
5.439E-2
4.437E-1
 1 14
42 3.90.1150.10 - Gene3D 1.338E-2 2.694E-2
1.354E-1
1.000E0
 1 36
43 IPR015422 PyrdxlP-dep Trfase major sub2 InterPro 1.374E-2 2.694E-2
1.354E-1
1.000E0
 1 37
44 IPR001331 GDS CDC24 CS InterPro 1.448E-2 2.694E-2
1.354E-1
1.000E0
 1 39
45 3.40.640.10 - Gene3D 1.485E-2 2.694E-2
1.354E-1
1.000E0
 1 40
46 IPR015421 PyrdxlP-dep Trfase major sub1 InterPro 1.559E-2 2.694E-2
1.354E-1
1.000E0
 1 42
47 IPR015424 PyrdxlP-dep Trfase InterPro 1.559E-2 2.694E-2
1.354E-1
1.000E0
 1 42
48 IPR018000 Neurotransmitter ion chnl CS InterPro 1.670E-2 2.694E-2
1.354E-1
1.000E0
 1 45
49 PF02932 Neur chan memb Pfam 1.706E-2 2.694E-2
1.354E-1
1.000E0
 1 46
50 IPR006202 Neur chan lig-bd InterPro 1.743E-2 2.694E-2
1.354E-1
1.000E0
 1 47
Show 45 more annotations

7: Pathway [Display Chart] 6 input genes in category / 35 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PW:0000456 Inhibitory synaptic transmission Pathway Ontology 5.806E-7 2.032E-5 8.426E-5 2.032E-5 2 3
2 1270157 Molybdenum cofactor biosynthesis BioSystems: REACTOME 2.901E-6 5.077E-5 2.105E-4 1.015E-4 2 6
3 545281 thio-molybdenum cofactor biosynthesis BioSystems: BIOCYC 4.819E-4 4.217E-3 1.749E-2 1.687E-2 1 1
4 142428 sulfite oxidation BioSystems: BIOCYC 4.819E-4 4.217E-3 1.749E-2 1.687E-2 1 1
5 PW:0000037 sulfur metabolic Pathway Ontology 9.637E-4 6.746E-3 2.797E-2 3.373E-2 1 2
6 1270145 Metabolism of water-soluble vitamins and cofactors BioSystems: REACTOME 1.461E-3 8.429E-3 3.495E-2
5.114E-2
 2 125
7 545283 molybdenum cofactor biosynthesis BioSystems: BIOCYC 1.927E-3 8.429E-3 3.495E-2
6.743E-2
 1 4
8 PW:0000427 molybdenum cofactor biosynthetic Pathway Ontology 1.927E-3 8.429E-3 3.495E-2
6.743E-2
 1 4
9 1270184 Sulfide oxidation to sulfate BioSystems: REACTOME 2.408E-3 9.239E-3 3.831E-2
8.427E-2
 1 5
10 SMP00041 Sulfate/Sulfite Metabolism SMPDB 2.889E-3 9.239E-3 3.831E-2
1.011E-1
 1 6
11 1270144 Metabolism of vitamins and cofactors BioSystems: REACTOME 2.904E-3 9.239E-3 3.831E-2
1.016E-1
 2 177
12 1270183 Degradation of cysteine and homocysteine BioSystems: REACTOME 4.330E-3 1.203E-2 4.987E-2
1.516E-1
 1 9
13 83026 Sulfur metabolism BioSystems: KEGG 4.811E-3 1.203E-2 4.987E-2
1.684E-1
 1 10
14 M477 Gamma-aminobutyric Acid Receptor Life Cycle MSigDB C2 BIOCARTA (v6.0) 4.811E-3 1.203E-2 4.987E-2
1.684E-1
 1 10
15 142373 superpathway of methionine degradation BioSystems: BIOCYC 6.250E-3 1.458E-2
6.047E-2
2.187E-1
 1 13
16 83018 Folate biosynthesis BioSystems: KEGG 7.209E-3 1.577E-2
6.539E-2
2.523E-1
 1 15
17 PW:0000140 pathway of folate cycle/metabolism Pathway Ontology 1.008E-2 2.075E-2
8.606E-2
3.528E-1
 1 21
18 1269952 Ligand-gated ion channel transport BioSystems: REACTOME 1.247E-2 2.384E-2
9.888E-2
4.364E-1
 1 26
19 1270181 Sulfur amino acid metabolism BioSystems: REACTOME 1.294E-2 2.384E-2
9.888E-2
4.531E-1
 1 27
20 M7014 PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase MSigDB C2 BIOCARTA (v6.0) 1.485E-2 2.599E-2
1.078E-1
5.198E-1
 1 31
21 M3494 Thrombin signaling and protease-activated receptors MSigDB C2 BIOCARTA (v6.0) 1.770E-2 2.950E-2
1.224E-1
6.196E-1
 1 37
22 1269448 NRAGE signals death through JNK BioSystems: REACTOME 2.952E-2 4.696E-2
1.947E-1
1.000E0
 1 62
Show 17 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 323 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7546736 Identification of a gephyrin binding motif on the glycine receptor beta subunit. Pubmed 2.879E-8 3.487E-6 2.217E-5 9.300E-6 2 2
2 17347650 Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function. Pubmed 8.637E-8 3.487E-6 2.217E-5 2.790E-5 2 3
3 17145751 A novel glycine receptor beta subunit splice variant predicts an unorthodox transmembrane topology. Assembly into heteromeric receptor complexes. Pubmed 8.637E-8 3.487E-6 2.217E-5 2.790E-5 2 3
4 25531214 Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin. Pubmed 8.637E-8 3.487E-6 2.217E-5 2.790E-5 2 3
5 11168555 Distribution of transcripts for the brain-specific GDP/GTP exchange factor collybistin in the developing mouse brain. Pubmed 8.637E-8 3.487E-6 2.217E-5 2.790E-5 2 3
6 19723286 Splice-specific roles of glycine receptor alpha3 in the hippocampus. Pubmed 8.637E-8 3.487E-6 2.217E-5 2.790E-5 2 3
7 26613940 Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy. Pubmed 8.637E-8 3.487E-6 2.217E-5 2.790E-5 2 3
8 21829170 Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C. Pubmed 8.637E-8 3.487E-6 2.217E-5 2.790E-5 2 3
9 20301437 Hyperekplexia Pubmed 2.879E-7 1.033E-5 6.567E-5 9.298E-5 2 5
10 25518936 Asef controls vascular endothelial permeability and barrier recovery in the lung. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
11 23665285 SUOX is a promising diagnostic and prognostic biomarker for hepatocellular carcinoma. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
12 18425804 Glycine receptor-mediated synaptic transmission regulates the maturation of ganglion cell synaptic connectivity. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
13 28872638 Modulation of defensive reactivity by GLRB allelic variation: converging evidence from an intermediate phenotype approach. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
14 12819232 A novel protein, densin, expressed by glomerular podocytes. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
15 24985044 Detergent-dependent separation of postsynaptic density, membrane rafts and other subsynaptic structures from the synaptic plasma membrane of rat forebrain. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
16 12112661 Isolated sulfite oxidase deficiency: identification of 12 novel SUOX mutations in 10 patients. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
17 24643514 Identification of risk genes for autism spectrum disorder through copy number variation analysis in Austrian families. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
18 22854042 Cofactor-dependent maturation of mammalian sulfite oxidase links two mitochondrial import pathways. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
19 9990024 The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
20 18985319 Positive allosteric modulatory effects of ajulemic acid at strychnine-sensitive glycine alpha1- and alpha1beta-receptors. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
21 17293395 Multiple association states between glycine receptors and gephyrin identified by SPT analysis. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
22 22975842 Effects of mutating aromatic surface residues of the heme domain of human sulfite oxidase on its heme midpoint potential, intramolecular electron transfer, and steady-state kinetics. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
23 11418245 The human gephyrin (GPHN) gene: structure, chromosome localization and expression in non-neuronal cells. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
24 10651857 Transient neuromotor phenotype in transgenic spastic mice expressing low levels of glycine receptor beta-subunit: an animal model of startle disease. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
25 1319186 Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
26 26171830 Oxygen reactivity of mammalian sulfite oxidase provides a concept for the treatment of sulfite oxidase deficiency. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
27 9430649 An actively retrotransposing, novel subfamily of mouse L1 elements. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
28 9813098 Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in neurons and implicated in plasma membrane dynamics and cell process formation. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
29 12525888 Cloning and characterization of a novel splice variant of the brain-specific protein densin-180. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
30 12056449 Detection of glycine receptor/Cl- channel beta subunit transcripts in mouse testis. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
31 23238346 Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
32 23709172 Paralemmin-1 is expressed in lymphatic endothelial cells and modulates cell migration, cell maturation and tumor lymphangiogenesis. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
33 11414787 Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypes. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
34 12832761 The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
35 15689563 Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
36 28167838 GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
37 12809985 Spinal inhibitory synaptic transmission in the glycine receptor mouse mutant spastic. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
38 9600976 Human sulfite oxidase R160Q: identification of the mutation in a sulfite oxidase-deficient patient and expression and characterization of the mutant enzyme. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
39 17039495 Densin is a novel cell membrane protein of Sertoli cells in the testis. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
40 19897489 The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
41 17368066 Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
42 7599189 Molecular cloning of human liver sulfite oxidase. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
43 25535349 Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
44 20063894 Effects of interdomain tether length and flexibility on the kinetics of intramolecular electron transfer in human sulfite oxidase. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
45 19383528 Inhibitory postsynaptic membrane specializations are formed in gephyrin-deficient mice. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
46 1338094 Receptive field organization of retinal ganglion cells in the spastic mutant mouse. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
47 23077067 A comprehensive small interfering RNA screen identifies signaling pathways required for gephyrin clustering. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
48 23184146 GLRB is the third major gene of effect in hyperekplexia. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
49 11056469 Reduced synaptic clustering of GABA and glycine receptors in the retina of the gephyrin null mutant mouse. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
50 12368985 A novel mutation in neonatal isolated sulphite oxidase deficiency. Pubmed 1.833E-4 4.661E-4 2.963E-3
5.920E-2
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 122 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:GLRB GLRB interactions 1.217E-5 1.485E-3 7.995E-3 1.485E-3 2 14
2 int:GPHN GPHN interactions 1.038E-4 6.331E-3 3.410E-2 1.266E-2 2 40
3 int:KMO KMO interactions 1.581E-3 3.705E-2
1.995E-1
1.929E-1
 1 4
4 int:RIMKLA RIMKLA interactions 1.581E-3 3.705E-2
1.995E-1
1.929E-1
 1 4
5 int:SPATS1 SPATS1 interactions 1.581E-3 3.705E-2
1.995E-1
1.929E-1
 1 4
6 int:AGAP2 AGAP2 interactions 2.395E-3 3.705E-2
1.995E-1
2.922E-1
 2 193
7 int:KHDRBS1 KHDRBS1 interactions 2.420E-3 3.705E-2
1.995E-1
2.952E-1
 2 194
8 int:CES3 CES3 interactions 2.765E-3 3.705E-2
1.995E-1
3.373E-1
 1 7
9 int:IFIT1B IFIT1B interactions 2.765E-3 3.705E-2
1.995E-1
3.373E-1
 1 7
10 int:ARHGEF9 ARHGEF9 interactions 3.554E-3 3.705E-2
1.995E-1
4.336E-1
 1 9
11 int:SUOX SUOX interactions 3.948E-3 3.705E-2
1.995E-1
4.817E-1
 1 10
12 int:ODF3L2 ODF3L2 interactions 3.948E-3 3.705E-2
1.995E-1
4.817E-1
 1 10
13 int:ARHGEF4 ARHGEF4 interactions 3.948E-3 3.705E-2
1.995E-1
4.817E-1
 1 10
14 int:SPANXN3 SPANXN3 interactions 4.736E-3 3.812E-2
2.053E-1
5.778E-1
 1 12
15 int:KLKB1 KLKB1 interactions 5.130E-3 3.812E-2
2.053E-1
6.259E-1
 1 13
16 int:NQO2 NQO2 interactions 5.130E-3 3.812E-2
2.053E-1
6.259E-1
 1 13
17 int:TSSK1B TSSK1B interactions 7.097E-3 3.812E-2
2.053E-1
8.658E-1
 1 18
18 int:HSD17B8 HSD17B8 interactions 7.097E-3 3.812E-2
2.053E-1
8.658E-1
 1 18
19 int:DRD3 DRD3 interactions 7.490E-3 3.812E-2
2.053E-1
9.138E-1
 1 19
20 int:CHIA CHIA interactions 7.490E-3 3.812E-2
2.053E-1
9.138E-1
 1 19
21 int:ZNF576 ZNF576 interactions 7.883E-3 3.812E-2
2.053E-1
9.617E-1
 1 20
22 int:CRTAC1 CRTAC1 interactions 7.883E-3 3.812E-2
2.053E-1
9.617E-1
 1 20
23 int:ADGRB1 ADGRB1 interactions 8.276E-3 3.812E-2
2.053E-1
1.000E0
 1 21
24 int:PALM PALM interactions 8.276E-3 3.812E-2
2.053E-1
1.000E0
 1 21
25 int:STS STS interactions 8.668E-3 3.812E-2
2.053E-1
1.000E0
 1 22
26 int:LRRC7 LRRC7 interactions 8.668E-3 3.812E-2
2.053E-1
1.000E0
 1 22
27 int:GABRA3 GABRA3 interactions 9.061E-3 3.812E-2
2.053E-1
1.000E0
 1 23
28 int:NRN1 NRN1 interactions 9.061E-3 3.812E-2
2.053E-1
1.000E0
 1 23
29 int:NEMP1 NEMP1 interactions 9.061E-3 3.812E-2
2.053E-1
1.000E0
 1 23
30 int:GABRA1 GABRA1 interactions 9.845E-3 3.976E-2
2.141E-1
1.000E0
 1 25
31 int:MOCOS MOCOS interactions 1.024E-2 3.976E-2
2.141E-1
1.000E0
 1 26
32 int:KLK11 KLK11 interactions 1.102E-2 3.976E-2
2.141E-1
1.000E0
 1 28
33 int:CTNND2 CTNND2 interactions 1.102E-2 3.976E-2
2.141E-1
1.000E0
 1 28
34 int:SEPT8 SEPT8 interactions 1.259E-2 3.976E-2
2.141E-1
1.000E0
 1 32
35 int:CHRNA3 CHRNA3 interactions 1.259E-2 3.976E-2
2.141E-1
1.000E0
 1 32
36 int:GRIA3 GRIA3 interactions 1.259E-2 3.976E-2
2.141E-1
1.000E0
 1 32
37 int:PLAU PLAU interactions 1.259E-2 3.976E-2
2.141E-1
1.000E0
 1 32
38 int:TULP2 TULP2 interactions 1.298E-2 3.976E-2
2.141E-1
1.000E0
 1 33
39 int:TROAP TROAP interactions 1.298E-2 3.976E-2
2.141E-1
1.000E0
 1 33
40 int:TOR1A TOR1A interactions 1.337E-2 3.976E-2
2.141E-1
1.000E0
 1 34
41 int:PPP4R1 PPP4R1 interactions 1.415E-2 3.976E-2
2.141E-1
1.000E0
 1 36
42 int:FHOD1 FHOD1 interactions 1.415E-2 3.976E-2
2.141E-1
1.000E0
 1 36
43 int:HOMEZ HOMEZ interactions 1.610E-2 3.976E-2
2.141E-1
1.000E0
 1 41
44 int:ASIC4 ASIC4 interactions 1.610E-2 3.976E-2
2.141E-1
1.000E0
 1 41
45 int:COX6B1 COX6B1 interactions 1.610E-2 3.976E-2
2.141E-1
1.000E0
 1 41
46 int:ROCK2 ROCK2 interactions 1.610E-2 3.976E-2
2.141E-1
1.000E0
 1 41
47 int:PAAF1 PAAF1 interactions 1.649E-2 3.976E-2
2.141E-1
1.000E0
 1 42
48 int:HCN1 HCN1 interactions 1.649E-2 3.976E-2
2.141E-1
1.000E0
 1 42
49 int:TSHR TSHR interactions 1.688E-2 3.976E-2
2.141E-1
1.000E0
 1 43
50 int:BTNL8 BTNL8 interactions 1.688E-2 3.976E-2
2.141E-1
1.000E0
 1 43
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2q22 2q22 4.039E-4 2.827E-3 7.330E-3 2.827E-3 1 2
2 18q12 18q12 2.623E-3 9.179E-3 2.380E-2 1.836E-2 1 13
3 14q23.3 14q23.3 5.441E-3 1.093E-2 2.833E-2 3.808E-2 1 27
4 4q31.3 4q31.3 6.244E-3 1.093E-2 2.833E-2 4.371E-2 1 31
5 12q13.2 12q13.2 1.106E-2 1.548E-2 4.013E-2
7.739E-2
 1 55
6 1p31.1 1p31.1 1.425E-2 1.663E-2 4.311E-2
9.977E-2
 1 71
7 19p13.3 19p13.3 4.883E-2 4.883E-2
1.266E-1
3.418E-1
 1 247
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 31 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 3 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 868 Glycine receptors genenames.org 8.243E-4 3.297E-3 6.869E-3 3.297E-3 1 5
2 722 Rho guanine nucleotide exchange factors genenames.org 1.084E-2 2.169E-2 4.518E-2 4.338E-2 1 66
3 1220 Membrane associated guanylate kinases|PDZ domain containing genenames.org 2.486E-2 3.314E-2
6.904E-2
9.942E-2
 1 152
4 682 Zinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors genenames.org 3.359E-2 3.359E-2
6.997E-2
1.343E-1
 1 206

13: Coexpression [Display Chart] 7 input genes in category / 578 annotations before applied cutoff / 23137 genes in category

No results to display

14: Coexpression Atlas [Display Chart] 7 input genes in category / 340 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PCBC ratio DE cord blood vs DE blastocyst cfr-2X-p05 DE cord blood vs DE blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 5.452E-5 1.854E-2
1.188E-1
 1.854E-2 3 257
2 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k1 500 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.752E-4 3.467E-2
2.221E-1
9.358E-2
 2 80
3 Facebase RNAseq e9.5 Maxillary Arch 1000 K2 FacebaseRNAseq e9.5 Maxillary Arch top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 6.284E-4 3.467E-2
2.221E-1
2.137E-1
 2 121
4 Facebase RNAseq e8.5 Non-Floor Plate Neural Epithelium 1000 K1 FacebaseRNAseq e8.5 Non-Floor Plate Neural Epithelium top-relative-expression-ranked 1000 k-means-cluster#1 FaceBase_RNAseq 6.704E-4 3.467E-2
2.221E-1
2.279E-1
 2 125
5 Facebase RNAseq e9.5 Facial Mesenchyne 1000 K1 FacebaseRNAseq e9.5 Facial Mesenchyne top-relative-expression-ranked 1000 k-means-cluster#1 FaceBase_RNAseq 6.704E-4 3.467E-2
2.221E-1
2.279E-1
 2 125
6 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k2 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.919E-4 3.467E-2
2.221E-1
2.352E-1
 2 127
7 Facebase RNAseq ratio e9.5 MandibularArch vs MaxillaryArch 1000 K3 FacebaseRNAseq ratio e9.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 7.137E-4 3.467E-2
2.221E-1
2.427E-1
 2 129
8 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Intrahepatic/3/4 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Intrahepatic/3/4 TCGA-Bile Duct 9.127E-4 3.879E-2
2.486E-1
3.103E-1
 2 146
Show 3 more annotations

15: Computational [Display Chart] 5 input genes in category / 24 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M15002 MODULE 396 Genes in the cancer module 396. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.965E-3 4.768E-2
1.800E-1
1.432E-1
 1 12
2 M12229 MODULE 381 Genes in the cancer module 381. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.965E-3 4.768E-2
1.800E-1
1.432E-1
 1 12
3 M3806 MODULE 215 Neurotransmitter (GABA) receptor. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.452E-3 4.768E-2
1.800E-1
1.788E-1
 1 15
4 M17013 MODULE 141 Genes in the cancer module 141. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.947E-3 4.768E-2
1.800E-1
1.907E-1
 1 16

16: MicroRNA [Display Chart] 7 input genes in category / 186 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1911-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.226E-5 4.140E-3 2.404E-2 4.140E-3 2 75
2 hsa-miR-361-5p:PITA hsa-miR-361-5p:PITA TOP PITA 2.802E-4 1.080E-2
6.270E-2
5.212E-2
 2 266
3 hsa-miR-935:PITA hsa-miR-935:PITA TOP PITA 3.148E-4 1.080E-2
6.270E-2
5.855E-2
 2 282
4 AAGCCAT,MIR-135A:MSigDB AAGCCAT,MIR-135A:MSigDB MSigDB 3.923E-4 1.080E-2
6.270E-2
7.297E-2
 2 315
5 AAGCCAT,MIR-135B:MSigDB AAGCCAT,MIR-135B:MSigDB MSigDB 3.923E-4 1.080E-2
6.270E-2
7.297E-2
 2 315
6 hsa-miR-10a*:mirSVR highEffct hsa-miR-10a*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.355E-4 1.080E-2
6.270E-2
8.101E-2
 2 332
7 hsa-miR-1271:PITA hsa-miR-1271:PITA TOP PITA 5.003E-4 1.080E-2
6.270E-2
9.306E-2
 2 356
8 hsa-miR-96:PITA hsa-miR-96:PITA TOP PITA 5.059E-4 1.080E-2
6.270E-2
9.410E-2
 2 358
9 hsa-miR-380:PITA hsa-miR-380:PITA TOP PITA 6.243E-4 1.080E-2
6.270E-2
1.161E-1
 2 398
10 hsa-miR-1284:PITA hsa-miR-1284:PITA TOP PITA 7.177E-4 1.080E-2
6.270E-2
1.335E-1
 2 427
11 hsa-miR-4316:mirSVR highEffct hsa-miR-4316:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.345E-4 1.080E-2
6.270E-2
1.366E-1
 2 432
12 hsa-miR-579:PITA hsa-miR-579:PITA TOP PITA 7.446E-4 1.080E-2
6.270E-2
1.385E-1
 2 435
13 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 7.549E-4 1.080E-2
6.270E-2
1.404E-1
 2 438
14 hsa-miR-597:mirSVR highEffct hsa-miR-597:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.050E-4 1.202E-2
6.980E-2
1.683E-1
 2 480
15 hsa-miR-6854-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.743E-3 2.161E-2
1.255E-1
3.242E-1
 1 18
16 GTAGGCA,MIR-189:MSigDB GTAGGCA,MIR-189:MSigDB MSigDB 2.613E-3 3.038E-2
1.764E-1
4.861E-1
 1 27
17 hsa-miR-7107-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.290E-3 3.500E-2
2.032E-1
6.119E-1
 1 34
18 hsa-miR-6753-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.387E-3 3.500E-2
2.032E-1
6.299E-1
 1 35
19 hsa-miR-4320:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.739E-3 4.028E-2
2.338E-1
8.814E-1
 1 49
20 hsa-miR-517b:PITA hsa-miR-517b:PITA TOP PITA 4.739E-3 4.028E-2
2.338E-1
8.814E-1
 1 49
21 ACATATC,MIR-190:MSigDB ACATATC,MIR-190:MSigDB MSigDB 5.510E-3 4.028E-2
2.338E-1
1.000E0
 1 57
22 hsa-miR-619-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.474E-3 4.028E-2
2.338E-1
1.000E0
 1 67
23 hsa-miR-513b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.667E-3 4.028E-2
2.338E-1
1.000E0
 1 69
24 hsa-miR-6748-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.052E-3 4.028E-2
2.338E-1
1.000E0
 1 73
25 hsa-miR-4254:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.341E-3 4.028E-2
2.338E-1
1.000E0
 1 76
26 hsa-miR-4662a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.438E-3 4.028E-2
2.338E-1
1.000E0
 1 77
27 hsa-miR-4761-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.438E-3 4.028E-2
2.338E-1
1.000E0
 1 77
28 hsa-miR-541-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.208E-3 4.028E-2
2.338E-1
1.000E0
 1 85
29 hsa-miR-492:PITA hsa-miR-492:PITA TOP PITA 8.208E-3 4.028E-2
2.338E-1
1.000E0
 1 85
30 hsa-miR-6753-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.208E-3 4.028E-2
2.338E-1
1.000E0
 1 85
31 TCTGATA,MIR-361:MSigDB TCTGATA,MIR-361:MSigDB MSigDB 8.400E-3 4.028E-2
2.338E-1
1.000E0
 1 87
32 hsa-miR-1227:PITA hsa-miR-1227:PITA TOP PITA 8.496E-3 4.028E-2
2.338E-1
1.000E0
 1 88
33 hsa-miR-934:PITA hsa-miR-934:PITA TOP PITA 9.362E-3 4.028E-2
2.338E-1
1.000E0
 1 97
34 hsa-miR-4733-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.938E-3 4.028E-2
2.338E-1
1.000E0
 1 103
35 GCACCTT,MIR-18A:MSigDB GCACCTT,MIR-18A:MSigDB MSigDB 1.003E-2 4.028E-2
2.338E-1
1.000E0
 1 104
36 GCACCTT,MIR-18B:MSigDB GCACCTT,MIR-18B:MSigDB MSigDB 1.003E-2 4.028E-2
2.338E-1
1.000E0
 1 104
37 hsa-miR-6865-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.023E-2 4.028E-2
2.338E-1
1.000E0
 1 106
38 hsa-miR-4693-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.042E-2 4.028E-2
2.338E-1
1.000E0
 1 108
39 hsa-miR-3944-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.128E-2 4.028E-2
2.338E-1
1.000E0
 1 117
40 hsa-miR-548o-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.138E-2 4.028E-2
2.338E-1
1.000E0
 1 118
41 hsa-miR-1323:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.157E-2 4.028E-2
2.338E-1
1.000E0
 1 120
42 hsa-miR-215-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.176E-2 4.028E-2
2.338E-1
1.000E0
 1 122
43 CAGCCTC,MIR-485-5P:MSigDB CAGCCTC,MIR-485-5P:MSigDB MSigDB 1.253E-2 4.028E-2
2.338E-1
1.000E0
 1 130
44 hsa-miR-5691:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.263E-2 4.028E-2
2.338E-1
1.000E0
 1 131
45 hsa-miR-6507-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.272E-2 4.028E-2
2.338E-1
1.000E0
 1 132
46 hsa-miR-6805-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.272E-2 4.028E-2
2.338E-1
1.000E0
 1 132
47 hsa-miR-134:PITA hsa-miR-134:PITA TOP PITA 1.282E-2 4.028E-2
2.338E-1
1.000E0
 1 133
48 hsa-miR-1304:PITA hsa-miR-1304:PITA TOP PITA 1.291E-2 4.028E-2
2.338E-1
1.000E0
 1 134
49 hsa-miR-5192:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.291E-2 4.028E-2
2.338E-1
1.000E0
 1 134
50 hsa-miR-3194-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.330E-2 4.028E-2
2.338E-1
1.000E0
 1 138
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 1742 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000023932 molybdenum Stitch 1.311E-7 2.283E-4 1.836E-3 2.283E-4 4 181
2 CID000139765 oxomolybdenum Stitch 8.047E-7 7.009E-4 5.636E-3 1.402E-3 2 5
3 CID000001084 thiosulfate Stitch 1.433E-6 7.063E-4 5.679E-3 2.497E-3 3 80
4 CID000000459 CPD-4 Stitch 2.047E-6 7.063E-4 5.679E-3 3.566E-3 3 90
5 CID000001845 DCQX Stitch 2.895E-6 7.063E-4 5.679E-3 5.044E-3 2 9
6 CID005311059 AC1NSJX8 Stitch 2.895E-6 7.063E-4 5.679E-3 5.044E-3 2 9
7 CID000073000 pterin Stitch 3.549E-6 7.063E-4 5.679E-3 6.182E-3 3 108
8 CID000086845 urothione Stitch 3.619E-6 7.063E-4 5.679E-3 6.304E-3 2 10
9 CID000001152 tungstate Stitch 3.649E-6 7.063E-4 5.679E-3 6.356E-3 3 109
10 CID000024621 molybdate Stitch 5.919E-6 1.031E-3 8.290E-3 1.031E-2 3 128
11 CID000000498 Mpt-gmp Stitch 1.229E-5 1.946E-3 1.565E-2 2.141E-2 2 18
12 2072 DN Cefotaxime sodium salt [64485-93-4]; Down 200; 8.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.156E-5 2.978E-3 2.394E-2 3.756E-2 3 197
13 380 UP tamoxifen citrate; Up 200; 1uM; MCF7; HG-U133A Broad Institute CMAP Up 2.222E-5 2.978E-3 2.394E-2 3.871E-2 3 199
14 CID000000790 hypoxanthine Stitch 2.998E-5 3.731E-3 3.000E-2
5.223E-2
 3 220
15 CID000014830 Blue Shield Stitch 3.488E-5 4.051E-3 3.257E-2
6.076E-2
 2 30
16 CID000023850 NSC344479 Stitch 4.495E-5 4.885E-3 3.928E-2
7.831E-2
 2 34
17 CID000009649 dimethoxystrychnine Stitch 4.767E-5 4.885E-3 3.928E-2
8.304E-2
 2 35
18 CID000004843 piracetam Stitch 5.630E-5 5.440E-3 4.374E-2
9.808E-2
 2 38
19 CID000001232 HA-966 Stitch 5.933E-5 5.440E-3 4.374E-2
1.034E-1
 2 39
20 CID000000098 3-mercaptopyruvate Stitch 8.646E-5 7.531E-3
6.055E-2
1.506E-1
 2 47
21 CID006323497 rifapentine Stitch 1.230E-4 1.020E-2
8.204E-2
2.143E-1
 2 56
22 CID000107699 CGP 35348 Stitch 1.509E-4 1.143E-2
9.190E-2
2.629E-1
 2 62
23 CID000059708 etiracetam Stitch 1.509E-4 1.143E-2
9.190E-2
2.629E-1
 2 62
24 CID000004816 picrotoxinine Stitch 1.659E-4 1.204E-2
9.683E-2
2.890E-1
 2 65
25 CID000001405 CB3717 Stitch 2.094E-4 1.459E-2
1.173E-1
3.648E-1
 2 73
26 CID000002802 clonazepam Stitch 2.643E-4 1.525E-2
1.226E-1
4.603E-1
 2 82
27 CID003899541 DNQX Stitch 2.707E-4 1.525E-2
1.226E-1
4.716E-1
 2 83
28 CID000001248 AC1L1B1W Stitch 2.773E-4 1.525E-2
1.226E-1
4.831E-1
 2 84
29 CID000087129 AC1L3D0C Stitch 3.065E-4 1.525E-2
1.226E-1
5.339E-1
 1 1
30 DB03983 (Molybdopterin-S,S)-Dioxo-Thio-Molybdenum(V) Drug Bank 3.065E-4 1.525E-2
1.226E-1
5.339E-1
 1 1
31 DB03766 Propanoic Acid Drug Bank 3.065E-4 1.525E-2
1.226E-1
5.339E-1
 1 1
32 CID006636248 AC1O7GKW Stitch 3.065E-4 1.525E-2
1.226E-1
5.339E-1
 1 1
33 CID000138278 o-mercaptobenzyl alcohol Stitch 3.065E-4 1.525E-2
1.226E-1
5.339E-1
 1 1
34 CID000516933 AC1O1I5D Stitch 3.065E-4 1.525E-2
1.226E-1
5.339E-1
 1 1
35 CID000160916 sodium sulfite heptahydrate Stitch 3.065E-4 1.525E-2
1.226E-1
5.339E-1
 1 1
36 CID000023964 tungsten Stitch 3.546E-4 1.716E-2
1.380E-1
6.177E-1
 2 95
37 CID000000144 5-HTP Stitch 4.007E-4 1.887E-2
1.517E-1
6.981E-1
 2 101
38 CID000001188 xanthine Stitch 5.557E-4 2.135E-2
1.716E-1
9.680E-1
 2 119
39 CID003037804 di(carboxamidomethyl)molybdopterin Stitch 6.129E-4 2.135E-2
1.716E-1
1.000E0
 1 2
40 CID000516928 AC1O1I54 Stitch 6.129E-4 2.135E-2
1.716E-1
1.000E0
 1 2
41 CID006419716 AC1O4WBW Stitch 6.129E-4 2.135E-2
1.716E-1
1.000E0
 1 2
42 ctd:C022261 molybdenum cofactor CTD 6.129E-4 2.135E-2
1.716E-1
1.000E0
 1 2
43 CID000069530 NSC229609 Stitch 6.129E-4 2.135E-2
1.716E-1
1.000E0
 1 2
44 CID006396940 phenylgermanium Stitch 6.129E-4 2.135E-2
1.716E-1
1.000E0
 1 2
45 CID000001050 pyridoxal Stitch 7.142E-4 2.135E-2
1.716E-1
1.000E0
 2 135
46 CID000134664 benzodiazepine Stitch 7.896E-4 2.135E-2
1.716E-1
1.000E0
 2 142
47 CID000025041 ammonium sulfite Stitch 9.192E-4 2.135E-2
1.716E-1
1.000E0
 1 3
48 CID000151925 cyanotriphenylborate Stitch 9.192E-4 2.135E-2
1.716E-1
1.000E0
 1 3
49 CID005282223 xanthoxic acid Stitch 9.192E-4 2.135E-2
1.716E-1
1.000E0
 1 3
50 CID000066593 7-chloro-4-quinolinol Stitch 9.192E-4 2.135E-2
1.716E-1
1.000E0
 1 3
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 86 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 OMIN:149400 HYPEREKPLEXIA, HEREDITARY OMIM 9.593E-7 6.874E-5 3.462E-4 8.250E-5 2 4
2 C1835614 Hereditary Hyperexplexia DisGeNET Curated 1.598E-6 6.874E-5 3.462E-4 1.375E-4 2 5
3 C1836014 Exaggerated acoustic startle response DisGeNET Curated 4.473E-6 7.642E-5 3.850E-4 3.847E-4 2 8
4 C1740801 Exaggerated startle response DisGeNET Curated 4.473E-6 7.642E-5 3.850E-4 3.847E-4 2 8
5 C1848918 Increased startle response DisGeNET Curated 4.473E-6 7.642E-5 3.850E-4 3.847E-4 2 8
6 C0026826 Muscle Hypertonia DisGeNET Curated 5.332E-6 7.642E-5 3.850E-4 4.585E-4 3 88
7 C0234166 Hyperexplexia DisGeNET Curated 8.781E-6 1.079E-4 5.434E-4 7.552E-4 2 11
8 C0085292 Stiff-Person Syndrome DisGeNET BeFree 1.675E-5 1.801E-4 9.070E-4 1.440E-3 2 15
9 C1854990 Molybdenum Cofactor Deficiency, Complementation Group C DisGeNET Curated 4.320E-4 2.477E-3 1.248E-2 3.715E-2 1 1
10 cv:C0268624 Sulfite oxidase deficiency Clinical Variations 4.320E-4 2.477E-3 1.248E-2 3.715E-2 1 1
11 C2931746 Sulfocysteinuria DisGeNET Curated 4.320E-4 2.477E-3 1.248E-2 3.715E-2 1 1
12 cv:C1854990 Molybdenum cofactor deficiency, complementation group C Clinical Variations 4.320E-4 2.477E-3 1.248E-2 3.715E-2 1 1
13 C1863688 Xanthinuria, Type II DisGeNET Curated 4.320E-4 2.477E-3 1.248E-2 3.715E-2 1 1
14 cv:CN124881 Hyperekplexia 2 Clinical Variations 4.320E-4 2.477E-3 1.248E-2 3.715E-2 1 1
15 OMIN:272300 SULFOCYSTEINURIA OMIM 4.320E-4 2.477E-3 1.248E-2 3.715E-2 1 1
16 C4084968 Hereditary Hyperekplexia DisGeNET BeFree 8.638E-4 3.535E-3 1.781E-2
7.428E-2
 1 2
17 cv:C1835614 Hyperekplexia hereditary Clinical Variations 8.638E-4 3.535E-3 1.781E-2
7.428E-2
 1 2
18 C1848954 Generalized dystonia DisGeNET Curated 8.638E-4 3.535E-3 1.781E-2
7.428E-2
 1 2
19 C1848958 Decreased urinary sulfate DisGeNET Curated 8.638E-4 3.535E-3 1.781E-2
7.428E-2
 1 2
20 C3553291 HYPEREKPLEXIA 2 DisGeNET Curated 8.638E-4 3.535E-3 1.781E-2
7.428E-2
 1 2
21 C1848957 Increased urinary sulfite DisGeNET Curated 8.638E-4 3.535E-3 1.781E-2
7.428E-2
 1 2
22 C0236736 Cocaine-Related Disorders DisGeNET Curated 9.042E-4 3.535E-3 1.781E-2
7.776E-2
 2 108
23 OMIN:252150 MOLYBDENUM COFACTOR DEFICIENCY OMIM 1.295E-3 4.456E-3 2.245E-2
1.114E-1
 1 3
24 C0268119 Combined molybdoflavoprotein enzyme deficiency DisGeNET Curated 1.295E-3 4.456E-3 2.245E-2
1.114E-1
 1 3
25 C0268624 Sulfite oxidase deficiency DisGeNET Curated 1.295E-3 4.456E-3 2.245E-2
1.114E-1
 1 3
26 C0159020 Convulsions in the newborn DisGeNET BeFree 2.589E-3 8.565E-3 4.314E-2
2.227E-1
 1 6
27 C0700198 Pulmonary aspiration DisGeNET Curated 3.451E-3 1.060E-2
5.340E-2
2.968E-1
 1 8
28 C2712334 Actual Aspiration DisGeNET Curated 3.451E-3 1.060E-2
5.340E-2
2.968E-1
 1 8
29 20081125:Hakonarson Type 1 diabetes GWAS 3.882E-3 1.151E-2
5.799E-2
3.338E-1
 1 9
30 C0221333 Hypouricemia DisGeNET Curated 4.312E-3 1.236E-2
6.227E-2
3.709E-1
 1 10
31 C1445953 Poor eye contact DisGeNET Curated 5.173E-3 1.348E-2
6.791E-2
4.449E-1
 1 12
32 C1860834 Infantile muscular hypotonia DisGeNET Curated 5.173E-3 1.348E-2
6.791E-2
4.449E-1
 1 12
33 C0850703 Frequent falls DisGeNET Curated 5.173E-3 1.348E-2
6.791E-2
4.449E-1
 1 12
34 C1836038 Poor head control DisGeNET Curated 6.033E-3 1.526E-2
7.687E-2
5.188E-1
 1 14
35 C0751337 X-Linked Emery-Dreifuss Muscular Dystrophy DisGeNET Curated 6.463E-3 1.544E-2
7.777E-2
5.558E-1
 1 15
36 C0002063 Alkalosis DisGeNET Curated 6.463E-3 1.544E-2
7.777E-2
5.558E-1
 1 15
37 C0018991 Hemiplegia DisGeNET Curated 6.892E-3 1.560E-2
7.857E-2
5.927E-1
 1 16
38 C0457334 Acute monoblastic leukemia DisGeNET BeFree 6.892E-3 1.560E-2
7.857E-2
5.927E-1
 1 16
39 C0086439 Hypokinesia DisGeNET Curated 8.180E-3 1.759E-2
8.859E-2
7.035E-1
 1 19
40 C0013581 Ectopia Lentis DisGeNET Curated 8.180E-3 1.759E-2
8.859E-2
7.035E-1
 1 19
41 C0085631 Agitation DisGeNET Curated 9.466E-3 1.986E-2
1.000E-1
8.141E-1
 1 22
42 C0751122 Infantile Severe Myoclonic Epilepsy DisGeNET Curated 1.075E-2 2.201E-2
1.109E-1
9.246E-1
 1 25
43 C0443306 Spastic DisGeNET BeFree 1.332E-2 2.663E-2
1.342E-1
1.000E0
 1 31
44 C0234967 Choreoathetoid movements DisGeNET Curated 1.374E-2 2.686E-2
1.353E-1
1.000E0
 1 32
45 C0085583 Choreoathetosis DisGeNET Curated 1.673E-2 3.197E-2
1.610E-1
1.000E0
 1 39
46 C0423867 Fine hair DisGeNET Curated 1.843E-2 3.446E-2
1.736E-1
1.000E0
 1 43
47 C0003578 Apnea DisGeNET Curated 1.928E-2 3.528E-2
1.777E-1
1.000E0
 1 45
48 C1853743 Axial hypotonia DisGeNET Curated 1.971E-2 3.531E-2
1.778E-1
1.000E0
 1 46
49 C0270850 Idiopathic generalized epilepsy DisGeNET Curated 2.352E-2 4.128E-2
2.080E-1
1.000E0
 1 55
50 C0543888 Epileptic encephalopathy DisGeNET Curated 2.437E-2 4.191E-2
2.111E-1
1.000E0
 1 57
Show 45 more annotations